WO2020132930A1 - 一种含多元锌的去屑止痒香波组合物 - Google Patents

一种含多元锌的去屑止痒香波组合物 Download PDF

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WO2020132930A1
WO2020132930A1 PCT/CN2018/123837 CN2018123837W WO2020132930A1 WO 2020132930 A1 WO2020132930 A1 WO 2020132930A1 CN 2018123837 W CN2018123837 W CN 2018123837W WO 2020132930 A1 WO2020132930 A1 WO 2020132930A1
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zinc
weight
dandruff
composition
shampoo composition
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PCT/CN2018/123837
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English (en)
French (fr)
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赵文忠
李洪波
洪盛杰
林学镁
胡卫华
陈顺章
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拉芳家化股份有限公司
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Priority to PCT/CN2018/123837 priority Critical patent/WO2020132930A1/zh
Priority to CN201880024982.4A priority patent/CN110709059A/zh
Publication of WO2020132930A1 publication Critical patent/WO2020132930A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/604—Alkylpolyglycosides; Derivatives thereof, e.g. esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/006—Antidandruff preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/008—Preparations for oily hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Definitions

  • the invention belongs to the field of daily chemicals, and particularly relates to an anti-dandruff anti-itch shampoo composition containing multiple zinc.
  • Dander is medically called pityriasis scalp and is a skin disease caused by Malassezia (a type of fungus).
  • Malassezia a type of fungus
  • the massive proliferation of Malassezia on the scalp causes excessive hyperplasia of the scalp stratum corneum, which promotes the abnormal exfoliation of the stratum corneum cells in the form of white flakes, which is called dandruff.
  • anti-dandruff shampoo is a widely used method for people to solve the problem of dandruff.
  • Salicylic acid, zinc pyrithione (ZPT), pyrrolidone ethanolamine salt (OCT), glyphosate and ketoconazole are the main anti-dandruff agents on the market for anti-dandruff shampoos and other anti-dandruff products.
  • zinc pyrithione (Zinc pyrpythione) , ZPT) as an anti-dandruff agent has been widely used in various shampoo products.
  • Zinc pyrithione is an organic zinc salt, whose name is: zinc di(N-oxide pyridine-2-thiol anion), or N-oxide-2-mercaptopyridine zinc salt, which is N-oxide-2- Mercaptopyridine (PT) is used as a ligand to form a complex with zinc ions. In solution, this complex is easily decomposed to form ligands and zinc ions. Zinc ions can adsorb and destroy the function of the cell membrane and enter the cell membrane to allow certain cell components to escape, interfere with the cell metabolism process or interfere with the action of various enzymes, so that It loses its due biological function, and finally leads to cell death, and finally plays a role in sterilization. It can be seen that zinc plays an important role.
  • Zinc also has the effect of inhibiting 5-a reductase, thereby reducing the excessive secretion of sebum, supplementing zinc to the skin, and helping to maintain the normal metabolism of the skin.
  • Zinc complexes and zinc-containing compounds include organic zinc salts and inorganic zinc salts.
  • Zinc pyrithione as an organic zinc salt has good oil control and bacteriostatic effects, but it has a certain degree of degreasing, and the scalp and hair are dry after use.
  • Organic zinc salts also include organic acid zinc such as zinc gluconate, zinc lactate, zinc pyrrolidone carboxylate, etc.
  • inorganic zinc salts include zinc oxide, chloride Zinc, zinc sulfate, zinc carbonate, etc.,
  • Zinc oxide is insoluble in water like zinc pyrithione.
  • ordinary zinc oxide such as pharmaceutical grade zinc oxide
  • the commercially available zinc oxide ointment has a certain astringent and antibacterial and anti-inflammatory effects.
  • the study found that the antibacterial effect of zinc oxide depends on the specific surface area of zinc oxide.
  • Zinc oxide is rich in raw materials and low in price.
  • zinc is also an essential mineral element for the human body.
  • Zinc oxide, especially the large specific surface area has become one of the hot spots in the research of inorganic antibacterial agents.
  • Small-diameter zinc oxide or nano-zinc oxide usually has a large specific surface area and surface effect, and it is easy to produce affinity with contacting microorganisms and has bactericidal ability.
  • the mechanism is similar to that of zinc pyrithione.
  • ZnO slowly releases zinc ions in an aqueous medium. Zinc ions are gradually released. Due to the redox properties of zinc ions, when it is combined with the bacterial cell membrane, it reacts with the organic matter in it, destroying the structure of the membrane protein, making it inactive, and achieving the purpose of sterilization.
  • the holes on the surface of the nano-zinc oxide will generate electrons and directly participate in the reaction. The more holes, the more electrons will be generated and the sterilization ability will increase.
  • zinc ions directly contact bacteria to kill bacteria, and when the bacteria are killed, zinc ions will be released from the bacteria, and then contact with other bacteria to complete the new sterilization task, so it shows Good bactericidal activity.
  • the object of the present invention is to provide a shampoo composition, through the multi-zinc (organic zinc salt and inorganic zinc salt) and scalp soothing, sterilizing and anti-inflammatory plant-derived active ingredients to achieve scalp nourishment, convergence, oil control and inhibition Good antibacterial effect.
  • An object of the present invention is to provide an anti-dandruff anti-itch shampoo composition containing multiple zinc.
  • the anti-dandruff anti-itch shampoo composition of the present invention contains:
  • composition 0.1% to 30% by weight of the composition contains a multi-component zinc scalp anti-dandruff anti-itch composite active, which is composed of the following components:
  • the organic acid zinc mixture accounts for 10-30% of the weight of the composite active substance.
  • the organic acid zinc mixture is zinc gluconate: zinc lactate: pyrrolidone zinc carboxylate: zinc glycyrrhetinate, and in a weight ratio of 1:1:1:0.2 Proportional mixing
  • the inorganic zinc which accounts for 1-20% of the weight of the composite active substance, the inorganic zinc is zinc oxide, and the particle size of the zinc oxide is 0.01 ⁇ m-100 ⁇ m, and the specific surface area is 30-100 m 2 /g;
  • the suspending agent accounts for 1-10% of the weight of the composite active substance, and the suspending agent is modified starch;
  • Phenoxyethanol 0.5-1% of the weight of the composite active substance
  • the shampoo composition of the present invention wherein the anti-dandruff anti-itch composite active substance is composed of inorganic zinc salts such as zinc oxide, organic zinc salts such as organic acids containing zinc pyrrolidone carboxylate, zinc gluconate, zinc lactate and zinc glycyrrhetinate Mixture, and a combination of walnut shell extract and modified starch (3Zn 2+ ScalpV, 5Zn 2+ ScalpV).
  • inorganic zinc salts such as zinc oxide
  • organic zinc salts such as organic acids containing zinc pyrrolidone carboxylate, zinc gluconate, zinc lactate and zinc glycyrrhetinate Mixture
  • a combination of walnut shell extract and modified starch (3Zn 2+ ScalpV, 5Zn 2+ ScalpV).
  • the shampoo composition of the present invention wherein the anionic surfactant is selected from: alkyl sulfate ester salt, alkyl polyoxyethylene ether sulfate salt, fatty acid monoglyceride sulfate salt, alkyl sulfonate salt, coconut oil glycol At least one of sulfonate, sodium ⁇ -olefin sulfonate, N-acyl sarcosinate, N-acyl glutamate, and alkyl phosphate salt.
  • the anionic surfactant is selected from: alkyl sulfate ester salt, alkyl polyoxyethylene ether sulfate salt, fatty acid monoglyceride sulfate salt, alkyl sulfonate salt, coconut oil glycol At least one of sulfonate, sodium ⁇ -olefin sulfonate, N-acyl sarcosinate, N-acyl glutamate, and alkyl phosphate salt.
  • the shampoo composition of the present invention wherein the weight ratio of the coconut amphoteric sodium acetate and alkyl glucoside is 1:1.
  • the cationic polymer is selected from at least one of cationic cellulose polymer and cationic guar polymer.
  • the shampoo composition of the present invention adopts multi-zinc technology and plant-derived active ingredients, and has the combined effects of scalp nourishment, oil control and bacteriostasis, and can achieve long-term anti-dandruff and anti-itch effects after use.
  • the shampoo composition of the present invention contains 0.1% to 25% by weight of the composition, preferably 5% to 20% of the anti-dandruff anti-itch composite active, which is a creamy viscous liquid, 20 At °C, the density is 1.150-1.240, and the pH is 5.5-7.0.
  • the specific composition and activity of the anti-dandruff anti-itch composite active substance are as follows: zinc oxide is an anti-dandruff agent, which can inhibit the reproduction of Malassezia bacteria and regulate the oil secretion of the scalp.
  • the zinc oxide is a large specific surface zinc oxide (specific surface area 30-100m 2 /g, particle size 0.01 ⁇ m-20 ⁇ m) has the effect of inhibiting Malassezia; zinc gluconate: zinc lactate: zinc pyrrolidone carboxylate: zinc glycyrrhetinate in a mixture of organic acid zinc in a weight ratio of 1: It is mixed in the ratio of 1:1:0.2 to regulate the microecology of the scalp. It has the synergistic effects of nourishing and moisturizing the scalp and hair, astringent scalp, regulating scalp oil secretion, bacteriostasis, anti-dandruff and itching.
  • Zinc pyrrolidone carboxylate is a A metal amino acid compound designed by increasing synergy to reduce the secretion of sebum by inhibiting 5 ⁇ -reductase and playing a synergistic antibacterial effect.
  • Zinc glycyrrhetinate has anti-inflammatory, antibacterial and anti-allergic effects;
  • the walnut shell extract is ethanol
  • the extract has the functions of anti-oxidation and bacteriostasis;
  • the modified starch has the functions of suspending and stabilizing the anti-dandruff and anti-itch composite active and stabilizing the composition system.
  • the modified starch is such as Shanghai Huanqiu Industrial Supcare HS modified corn starch.
  • the active product content of the commercially available product of sodium laureth sulfate is 70%, and its appearance is white or light yellow paste.
  • the combined use of the coconut oil sodium isethionate and sodium laureth sulfate can produce good synergistic effects, such as: good washing ability, excellent mild performance and hard water resistance.
  • the shampoo composition of the present invention contains 1.0% to 10.0% of the composition by weight of the composition of coconut oil amphoteric sodium acetate and alkyl glucoside, the ratio of the coconut oil amphoteric sodium acetate and alkyl glucoside is 1:1 .
  • the coconut oil-based amphoteric sodium acetate is a colorless to slightly yellow transparent viscous liquid. Its commercially available product has an active content of 30%. At 25°C, its viscosity is 5000-10000, and its sodium chloride content is less than 9.0%.
  • the pH of 1% aqueous solution is 6.0-8.0, and its structural formula is RN(CH2COONa)2.
  • the coconut oil-based amphoteric sodium acetate has low irritation and is particularly gentle on the skin and eyes. It can significantly reduce its compatibility with anionic surfactants. It is irritating and has good foaming power. The foam is rich and fine, and the skin feels good. It can significantly improve the foam state of the formula system.
  • the alkyl glucoside includes lauryl glucoside, coco glucoside, decyl glucoside, and octyl/decyl glucoside, preferably decyl glucoside, the appearance of which is a light yellow turbid viscous liquid, which is commercially available
  • the active content of the product is 51%-55%
  • the pH value of its 20% 15% isopropanol solution is 11.5-12.5
  • its viscosity is 1000-6000 at 25°C.
  • decyl glucoside is preferred.
  • the decyl glucoside is derived from nature, has excellent gentle cleaning ability, and can improve the foam performance of shampoo. Improve the amount of foam and foam stability.
  • the compound use of the coconut oil-based amphoteric sodium acetate and decyl glucoside has good foam and skin compatibility, minimizes irritation and improves foaming speed.
  • the shampoo composition of the present invention contains 0.05% to 3.0% of cationic polymer by weight of the composition, the cationic polymer is selected from at least one of cationic cellulose polymer and cationic guar polymer, preferably cationic Guar gum.
  • the cationic guar gum is a product obtained by quaternizing guar gum, and its main component is guar propyltrimethylammonium chloride, and a series of cationic guar gums can be obtained according to different degrees of substitution
  • the product preferably has a degree of substitution of 0.1 to 0.2 and a nitrogen content of 1.3-1.7%.
  • the cationic guar gum used in the present invention has a viscosity of 3500 mPa.s to 4500 mPa.s in a 1% aqueous solution at 25°C;
  • Cationic cellulose polymer is a copolymer of hydroxyethyl cellulose and alkyl trimethyl ammonium chloride, which can be divided into high cationic substitution degree JR, medium cationic substitution degree LR and low cationic substitution degree according to the degree of cationic substitution
  • Three types of LK preferably cationic cellulose with medium cationic substitution degree.
  • the shampoo composition of the present invention may further include other optional components, including pearlescent agents, viscosity modifiers, chelating agents, pH adjusters, preservatives, pigments, and fragrances.
  • the pearlescent agent accounts for 0.05% to 3.0% by weight of the composition.
  • Non-limiting examples of the pearlescent agent are: ethylene glycol stearate monoester and ethylene glycol stearate diester, monostearic acid and palm Propylene glycol esters and glycerides, stearic acid alkyl alcohol amide magnesium stearate, finely dispersed zinc oxide and titanium dioxide, preferably ethylene glycol stearate diester.
  • the viscosity modifier accounts for 0.1% to 5.0% by weight of the composition.
  • Non-limiting examples of the viscosity modifier are: sodium chloride, ammonium chloride, monoethanolamine chloride, sodium sulfate, ammonium phosphate, hydroxyethyl Cellulose, hydroxypropyl cellulose, acrylic acid and long-chain alkyl methacrylate copolymer, acrylate/stearyl ether-20/methacrylate copolymer, methyl glucoside polyoxyethylene ether (120) Dioleate and so on.
  • the chelating agent accounts for 0.01% to 0.30% of the weight of the composition.
  • Non-limiting examples of the chelating agent are: ethylenediaminetetraacetic acid, disodium ethylenediaminetetraacetic acid, trisodium ethylenediaminetetraacetic acid, ethylenediamine Tetrasodium aminetetraacetic acid, etc., preferably disodium edetate;
  • the non-limiting examples of the pH adjusting agent are: citric acid, phosphoric acid, triethanolamine, sodium hydroxide, etc., adjust the pH of the system at 5.0 to 8.0, It is preferably 6.5 to 7.5; the selection of the preservatives, flavors, and pigments conforms to the provisions of cosmetic hygiene standards, and safe materials are used.
  • water is made up to the required amount.
  • anti-dandruff anti-itch composite active substance disperse modified starch in water, heat and stir until dissolved, then add phenoxyethanol, zinc organic acid mixture (weight ratio 1:1:1:1:0.2), walnut shell The extract and zinc oxide are stirred well and set aside.
  • the shampoo composition of the present invention can be prepared by any known or other effective techniques suitable for providing the shampoo composition.
  • the method of preparing the shampoo composition of the present invention includes conventional formulation and mixing techniques, and the final temperature reduction stage of the process is about 50 Add anti-dandruff anti-itch compound active at °C.
  • the shampoo composition of the present invention is used in a conventional way to clean and condition hair, and mainly includes the following steps:
  • the effective dose generally ranges from 1 to 50 grams, preferably from 2 to 20 grams;
  • a small amount of substances refers to those substances that are optional, such as preservatives, viscosity modifiers, pH adjusters, fragrances, colorings, etc. The selection of these small amounts of substances will vary with the specific The physical and chemical properties of the ingredients change.
  • a suitable method for preparing the shampoo composition described in Examples I-X is as follows: add an appropriate amount of water to the reaction tank, add guar gum to disperse under slow stirring, and heat to 60°C to 80°C with slow stirring, add Neutralize with moderate amount of citric acid. Then add sodium lauryl ether sulfate, sodium coconut isethionate, sodium coconut amphoteric acetate, decyl glucoside, ethylene glycol stearate, disodium edetate (if these are used) ), so that these substances are completely dispersed and dissolved, keep warm for 30 minutes, and begin to cool down.
  • the content (weight ratio) of each component of the anti-dandruff and anti-itch composite active substance in Examples I-X is: containing 20% of a mixture of zinc organic acid, the mixture of zinc organic acid is zinc gluconate: zinc lactate: pyrrolidone carboxylic acid
  • Zinc Zinc glycyrrhetinate is mixed in a weight ratio of 1:1:1:0.2; contains 2% walnut shell extract; contains 16.6% zinc oxide, the zinc oxide particle size is 0.05 ⁇ m, and the specific surface area is 80m 2 /g; containing 1% phenoxyethanol; containing 5% modified starch and the remaining water.
  • the detection standard of the shampoo composition of the present invention conforms to the national standard GB/T 29679 shampoo, and the specific details are shown in Table 5.
  • this method is a common method for testing the potency of antibiotics at home and abroad, and is also the method prescribed by the pharmacopoeia of various countries.
  • the drugs contained in the Oxford cup continue to diffuse around the Oxford cup to form a decreasing gradient concentration.
  • the growth of the bacterium to be tested is inhibited within the range of bacteriostatic concentration around the Oxford Cup, forming a transparent circle of sterile growth (ie, bacteriostatic circle).
  • the size of the zone of inhibition reflects the sensitivity of the bacterium to be tested to the measured drug, and is inversely related to the minimum (or minimum) inhibitory concentration (MIC) of the drug to be tested, that is, the larger the zone of inhibition , The smaller the MIC, the stronger its antibacterial effect.
  • MIC minimum inhibitory concentration
  • Medium preparation After the medium is weighed according to the formula, a proper amount of deionized water is dissolved, shaken and shaken, and then add water to the required volume.
  • Determination of antibacterial efficacy Shake the medium and pour into the plates, cool and solidify, about 15mL per plate. Add a certain percentage of bacterial suspension to the plate, and apply it evenly 3 times on the surface of the plate with a coating stick. Cover the dish and let it dry at room temperature for 5 minutes. Use tweezers to gently place the Oxford cup with an inner diameter of 6 mm on the solidified medium with tweezers. Aspirate the sample with a 1 mL disposable injection needle and add it to an Oxford cup, adding approximately 250 ⁇ L of sample to each cup. After incubating at a suitable temperature for a certain period of time, observe the size of the inhibition zone or use a vernier caliper to determine the diameter of the inhibition zone. When measuring the bacteriostatic ring, the bacteriostatic ring should be selected to grow evenly and completely aseptically. The diameter of the measurement should be bounded by the outer edge of the bacteriostatic ring.
  • Zinc oxide (large specific surface area) samples are dispersed in acetone (ZnO 25% content), and then diluted into 0.16-2.5% concentration of zinc oxide dispersion solution for use.
  • the blank control (without ZnO) samples are water And acetone.
  • the medium is weighed according to the formula and dissolved in deionized water, shaken and shaken, and then water is added to the required volume. Place the Erlenmeyer flask on the induction cooker with heating and stirring until the medium solution is slightly boiled, and keep this state for 5-10min. Put it in a sterilization pot and sterilize it at 121°C for 20 minutes. Take it out after cooling to 60°C. If there is no infection, it can be used.
  • the pharmaceutical grade zinc oxide and the large specific surface area zinc oxide were respectively suspended in acetone to prepare suspensions with a concentration ranging from the lowest concentration of 90PPM to 6000PPM, and divided into equal parts and put into the medium for cultivation. Finally, the Malassezia was observed. See Table 8 for the minimum inhibitory concentration MIC.
  • Test method Select 60 volunteers with moderate dandruff and itchy head, and request healthy patients with scalp without seborrheic dermatitis, no allergies, and no wounds. Before the trial, evaluate the sensory and hair images of the patients for patients to use The best embodiment shampoo of the present invention and the shampoo of the blank embodiment of the present invention, continue to use (use samples according to daily use frequency), stop using after the 14th day (two weeks), the 12th hour, 24th hour and Observation of dandruff and itchy head were made at 48 hours and scored. See Table 9 for comprehensive evaluation.
  • Volunteer skin scores before and after use 1, 2, 3, 4, 5 points, the higher the score, the better the effect: 1-2: invalid; 2-3: medium; 3-4: good; 4-5: very it is good.
  • the invalid percentage of the best embodiment of the present invention is significantly lower than that of the blank control embodiment of the present invention.

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Abstract

一种含多元锌的去屑止痒香波组合物，所述组合物除水外，还含有：（A）占组合物重量5.0％至40％的阴离子表面活性剂；（B）占组合物重量1.0％至10.0％的椰油两性醋酸钠和烷基葡糖苷的组合物；（C）占组合物重量0.1％至30％的含多元锌的头皮去屑止痒复合活性物，所述去屑止痒复合活性物是由氧化锌，吡咯烷酮羧酸锌，葡萄糖酸锌，乳酸锌，甘草亭酸锌、核桃壳提取物、改性淀粉、苯氧乙醇和水组成；（D）占组合物重量0.05％至2.0％的阳离子聚合物。

Description

一种含多元锌的去屑止痒香波组合物 技术领域
本发明属于日化领域，具体涉及一种含多元锌的去屑止痒香波组合物。
背景技术
皮屑在医学上称为头皮糠疹，是一种由马拉色菌(真菌中的一种)引起的皮肤病。马拉色菌在头皮上的大量繁殖引起头皮角质层的过度增生，从而促使角质层细胞以白色屑的形式异常脱落，即为头皮屑。
拉芳与中科院微生物研究所头皮微生态研究项目小组的研究结果表明，健康的头皮生态环境由酸碱度、油脂、菌群、代谢平衡等维持着平衡。当头皮油脂分泌失衡，头皮就会出油变得油腻；当头皮菌群环境失衡，嗜脂菌大量滋生，就会出现头痒的现象；而头皮角质层代谢过快，真菌成群也就形成头屑，不仅头痒难忍，甚至还有成块的白色物体脱落，另外不同地区的人群头皮微生物的分布也不同等.这些问题都是会导致头皮生态平衡遭到破坏。
日常生活中，选择去屑香波是人们解决头屑问题广泛采用的方法。水杨酸，吡硫翁锌(ZPT),吡咯克酮乙醇胺盐(OCT),甘宝素和酮康唑是市场上去屑香波及其它去屑产品主要去屑剂，其中，吡硫翁锌(Zinc pyrithione,ZPT)作为去屑剂已被广泛应用于各类洗发产品中。
吡硫翁锌是一种有机锌盐，其名称为：二(N-氧化吡啶-2-硫醇负离子)合锌，或N-氧化-2-巯基吡啶锌盐，是N-氧化-2-巯基吡啶(PT)作为配体与锌离子配位所形成的配合物。在溶液中，这个配合物易分解，形成配体和锌离子，锌离子能够吸附破坏细胞膜的功能并进入细胞膜内部使某些细胞成分逸出，干扰细胞代谢过程或干扰各种酶的作用，使其失去应有的生物功能，最后导致细胞的死亡，最后起到杀菌的作用，可见锌起到重要作用。
锌还具有抑制5-a还原酶的作用，从而减少皮脂的过度分泌，为肌肤补充锌元素，有助于保持皮肤的正常新陈代谢。锌的配合物及含锌化合物包含有机锌盐和无机锌盐。吡啶硫酮锌作为有机锌盐具有较好的控油和抑菌效果，但有一定的脱脂性，用后头皮和头发偏干。有机锌盐还包括有机酸锌如葡萄糖酸锌，乳酸锌，吡咯烷酮羧酸锌等溶解性好，具有协同保湿，控油，抑菌和协同去屑效果；此外，无机锌盐包括氧化锌，氯化锌，硫酸锌，碳酸锌等，
氧化锌与吡硫翁锌一样不溶于水。普通氧化锌(如医药级氧化锌)的应用如，市售的氧化锌软膏具有一定的收敛和抗菌消炎的作用。研究发现氧化锌抗菌效果大小取决于氧化锌比表面积的大小。氧化锌原料来源丰富，价格低廉，同时锌还是人体必需的矿物元素。氧化锌尤其是大比表面积已成为无机抗菌剂研究的热点之一。
小粒径的氧化锌或纳米氧化锌通常具有大比表面积和表面效应，容易与接触的微生物产生亲和力而具有杀菌能力，其机理与吡啶硫酮锌近似，ZnO在含水介质中缓慢释放锌离子，锌离子逐渐地游离出来，由于锌离子的氧化还原性，当它和细菌细胞膜相结合时，与其中的有机物发生反应，破坏了膜蛋白的结构，使其失去活性，达到杀菌目的。同时，纳米氧化锌表面的空穴会产生电子，直接参与反应，空穴数量越多就会产生更多的电子，其杀菌能力就增加。根据接 触式杀菌机理，锌离子与细菌直接接触后杀死细菌，而且当细菌被杀死后，锌离子又会从菌体中游离出来，再与其他细菌接触，完成新的杀菌任务，因此显示良好的杀菌活性。
本发明的目的是提供一种香波组合物，通过多锌(有机锌盐和无机锌盐)以及具有头皮舒缓，杀菌和消炎作用的源于植物的活性成分，达到头皮滋养，收敛，控油和抑菌止痒的良好效果。
发明内容
本发明的目的在于提供一种含多元锌的去屑止痒香波组合物。
本发明的去屑止痒香波组合物，除水外，该香波中含有：
(A)占组合物重量5.0％至40％的阴离子表面活性剂；
(B)占组合物重量1.0％至10.0％的椰油两性醋酸钠和烷基葡糖苷的组合物；
(C)占组合物重量0.1％至30％含有多元锌头皮去屑止痒复合活性物，所述多元锌去屑止痒复合活性物是由以下组分组成：
占复合活性物重量10-30％的有机酸锌混合物，该有机酸锌混合物是葡萄糖酸锌︰乳酸锌︰吡咯烷酮羧酸锌:甘草亭酸锌，并以重量比1:1︰1:0.2的比例混合；
占复合活性物重量1-20％的无机锌，该无机锌为氧化锌，且该氧化锌粒径为0.01μm-100μm，比表面积为30-100m 2/g；
占复合活性物重量0.01-5％的核桃壳提取物；
占复合活性物重量1-10％的悬浮剂，该悬浮剂为改性淀粉；
占复合活性物重量0.5-1％的苯氧乙醇
及余量的水；
(D)占组合物重量0.05-2.0％的阳离子聚合物。
本发明的香波组合物，其中所述去屑止痒复合活性物是由无机锌盐如氧化锌，有机锌盐如含吡咯烷酮羧酸锌、葡萄糖酸锌、乳酸锌和甘草亭酸锌的有机酸混合物，以及核桃壳提取物和改性淀粉组成的组合物(3Zn 2+ScalpV，5Zn 2+ScalpV)。
本发明的香波组合物，其中所述阴离子表面活性剂选自：烷基硫酸酯盐、烷基聚氧乙烯醚硫酸酯盐、脂肪酸单甘油酯硫酸盐、烷基磺酸盐、椰油羟乙基磺酸盐、α-烯烃磺酸钠、N-酰肌氨酸盐、N-酰谷氨酸盐、烷基磷酸酯盐中的至少一种。
本发明的香波组合物，其中所述椰油两性醋酸钠和烷基葡糖苷的重量比为1:1。
本发明的香波组合物，其中所述阳离子聚合物选自：阳离子纤维素聚合物、阳离子瓜尔胶聚合物中的至少一种。
本发明具有以下优点：
本发明的香波组合物，采用了多元锌技术和源于植物的活性成分，具有头皮滋养，控油和抑菌的组合效果，使用后能实现持久去屑和止痒效果。
具体实施方式
下面将对本发明的组分选择及作用进行详细说明。
本发明的香波组合物中含有占组合物重量0.1％至25％，优选5％至20％的去屑止痒复合活性物，所述去屑止痒复合活性物为乳色粘稠液体，20℃条件下其密度为1.150-1.240，pH值为5.5-7.0。所述去屑止痒复合活性物具体组成及活性如下：氧化锌为去屑剂，能够抑制马拉色菌的繁殖并调节头皮的油脂分泌，所述氧化锌为大比表面氧化锌(比表面积30-100m 2/g，粒径为0.01μm-20μm)具有抑制马拉色菌的效果；有机酸锌混合物中葡萄糖酸锌︰乳酸锌︰吡咯烷酮羧酸锌:甘草亭酸锌以重量比1:1︰1:0.2的比例混合，调节头皮微生态，具有头皮和头发滋养保湿、收敛头皮、调节头皮油脂分泌、抑菌和去屑止痒的协同作用，其中吡咯烷酮羧酸锌(ZnPCA)是一种通过增加协同作用而设计的金属氨基酸化合物通过抑制5α-还原酶来减少皮脂的分泌，起到协同抗菌作用，甘草亭酸锌具有抗炎、抗菌、抗过敏的作用；核桃壳提取物为乙醇提取物，具有抗氧化和抑菌的功能；改性淀粉具有悬浮与稳定去屑止痒复合活性物和稳定组合物体系的作用，改性淀粉如上海寰球实业Supcare HS改性玉米淀粉。
本发明的香波组合物中含有占组合物重量5.0％至40％的椰油羟乙基磺酸钠和月桂醇聚氧乙烯醚硫酸钠的组合物，所述椰油羟乙基磺酸钠和月桂醇聚氧乙烯醚硫酸钠的重量比为1:2-2:1，所述椰油羟乙基磺酸钠简称SCI,其结构式为：RCOOCH2CH2S03Na，R＝C12-C16烷基，其活性物含量85％，外观白色，温和具有耐硬水的特点。所述月桂醇聚氧乙烯醚硫酸钠简称AES,其结构式为RO(CH2CH2O)nSO3Na，R＝C12-C16烷基，n为2-3，优选平均乙氧化程度为n＝3。所述月桂醇聚氧乙烯醚硫酸钠市售产品的活性物含量为70％，其外观为白色或淡黄色糊状物。所述椰油羟乙基磺酸钠和月桂醇聚氧乙醚硫酸钠的复配使用，可以产生良好的协同效应，如：具有良好的洗涤能力、卓越的温和性能和抗硬水性能等。
本发明的香波组合物中含有占组合物重量1.0％至10.0％的椰油两性醋酸钠和烷基葡糖苷的组合物，所述椰油两性醋酸钠和烷基葡糖苷的比例为1：1。所述椰油基两性醋酸钠为无色至微黄色透明粘稠液体，其市售产品的活性物含量为30％，25℃条件下，其粘度为5000-10000，氯化钠含量小于9.0％，1％水溶液的pH为6.0-8.0，其结构式为RN(CH2COONa)2，所述椰油基两性醋酸钠的刺激性低，对皮肤、眼睛特别温和，与阴离子表面活性剂相配能显著降低其刺激性，且具有良好的发泡力，泡沫丰富细密，肤感好，能显著改善配方体系的泡沫状态。所述烷基葡糖苷包括月桂基葡糖苷、椰油基葡糖苷、癸基葡糖苷和辛基/癸基葡糖苷，优选癸基葡糖苷，其外观为浅黄色浑浊的粘性液体，其市售产品的活性物含量为51％-55％，其20％的15％异丙醇溶液的PH值为11.5-12.5，25℃条件下，其粘度为1000-6000。本发明优选癸基葡糖苷，所述癸基葡糖苷源于天然，具有卓越的温和清洁能力，能够改善香波的泡沫性能。提高泡沫的数量和泡沫稳定性。所述椰油基两性醋酸钠和癸基葡糖苷的复配使用具有良好的泡沫和皮肤相容性，把刺激性降到最低并提升发泡速度。
本发明的香波组合物中含有占组合物重量0.05％至3.0％的阳离子聚合物，所述阳离子聚合物选自：阳离子纤维素聚合物、阳离子瓜尔胶聚合物中的至少一种，优选阳离子瓜尔胶。所述阳离子瓜儿胶是将瓜儿胶季铵化后得到的产品，其主要组分为瓜儿胶丙基三甲基氯化铵，根据取代度的不同可得到一系列的阳离子瓜儿胶产品，优选取代度为0.1至0.2，含氮量为1.3-1.7％，用于本发明的阳离子瓜儿胶在25℃条件下，其1％水溶液的黏度3500mPa.s至4500mPa.s；所述阳离子纤维素聚合物是羟乙基纤维素与烷基三甲基氯化铵的共聚物，根据阳离子取代度的不同可分为：高阳离子取代度JR、中阳离子取代度LR和低阳离子取代度LK三种型号，优选中阳离子取代度的阳离子纤维素。
本发明的香波组合物还可以包含其它任选组分，包括珠光剂、黏度调节剂、螯合剂、pH调节剂、防腐剂、色素和香料等。所述珠光剂占组合物重量的0.05％至3.0％，所述珠光剂的非限定性实例有：乙二醇硬脂酸单酯和乙二醇硬脂酸双酯、单硬脂酸和棕榈酸丙二醇酯及甘油酯、硬脂酸烷基醇酰胺硬脂酸镁、微细分散的氧化锌和二氧化钛，优选乙二醇硬脂酸双酯。所述黏度调节剂占组合物重量的0.1％至5.0％，所述黏度调节剂的非限定性实例有：氯化钠、氯化铵、单乙醇胺氯化物、硫酸钠、磷酸铵、羟乙基纤维素、羟丙基纤维素、丙烯酸和长链烷基甲基丙烯酸酯共聚物、丙烯酸盐/硬脂醇醚-20/甲基丙烯酸盐共聚物、甲基葡糖苷聚氧乙烯醚(120)二油酸酯等。所述螯合剂占组合物重量的0.01％至0.30％，所述螯合剂的非限定性实例有：乙二胺四乙酸、乙二胺四乙酸二钠、乙二胺四乙酸三钠、乙二胺四乙酸四钠等，优选乙二胺四乙酸二钠；所述pH调节剂的非限定性实例有：柠檬酸、磷酸、三乙醇胺、氢氧化钠等，调节体系的pH在5.0至8.0，优选6.5至7.5；所述防腐剂、香精、色素的选取，符合化妆品卫生标准的规定，选用安全的原料。
本发明的香波组合物中，除了以上所述组分外，用水补至所需量。
制备方法
(1)核桃壳提取物的制备：核桃壳干燥后用三辊机磨碎成200目，以95乙醇为浸提剂，料液比1：20，浸提温度45℃，超声波功率调到250W，浸提2小时，过滤并减压浓缩得乙醇提取物。
(2)去屑止痒复合活性物的制备：将改性淀粉分散在水中，加热搅拌直到溶解，然后加入苯氧乙醇，有机酸锌混合物(重量比1：1︰1:0.2)，核桃壳提取物和氧化锌，搅拌均匀后备用。
(3)本发明香波组合物的制备：
本发明的香波组合物可以通过任何已知或其它有效的适用于提供香波组合物的技术制备，制备本发明的香波组合物的方法包括常规的配制和混合技术，在工艺的最后降温阶段约50℃时加入去屑止痒复合活性物。
使用方法
本发明的香波组合物以常规的清洁和调理头发的方式使用，主要包括以下几个步骤：
(A)用水将头发润湿；
(B)在所述头发上施用有效量的前述任一项权利要求的香波组合物，所述有效剂量的范围通常为1克至50克，优选2至20克；
(C)用水漂洗所述头发上的香波组合物。
这些步骤可以根据需要重复多次，以达到所寻求的清洁、滋润、调理、去屑等功效。
实施例
下面是本发明的香波组合物的非限定性实例。这些实施例的给出仅仅是为了说明的目的，并不能理解为对本发明的限定，因为在不脱离本发明的精神和范围的基础上，可以对本发明进行许多改变。在这些实施例中，除非特别说明，所有的浓度都是重量百分比。所用术语“少量物质”指的是任选的那些物质，如防腐剂、粘度调节剂、pH调节剂、香料、色素等，这些少量物质的选择将随着选定的用以制备本发明的特定成分的物理和化学特性而改变。
制备实施例Ⅰ-Ⅹ
合适的制备实施例Ⅰ-Ⅹ中所述香波组合物的方法如下：将适量水加入到反应罐中，在缓慢搅拌下加入瓜尔胶进行分散，在缓慢搅拌加热到60℃至80℃，加入适量的柠檬酸中和。接着加入月桂醇醚硫酸酯钠、椰油羟乙基磺酸钠、椰油两性醋酸钠、癸基葡糖苷、乙二醇硬脂酸双酯、乙二胺四乙酸二钠(如果使用这些物质)，使这些物质完全分散溶解，保温30分钟，开始降温。待温度降至50℃左右时加入去屑止痒复合活性物、氯化钠、柠檬酸、防腐剂、色素、香精等继续搅拌，确保得到均匀的混合物。在加入所有的组分后，可根据需要加入粘度调节剂和pH调节剂，调节产品的粘度和pH到6.5至7.5。任选地最后可以加入少量水补足。
实施例Ⅰ-Ⅴ(表1)
Figure PCTCN2018123837-appb-000001
Figure PCTCN2018123837-appb-000002
实施例Ⅵ-Ⅹ(表2)
Figure PCTCN2018123837-appb-000003
本发明的最佳实施例(表3)
Figure PCTCN2018123837-appb-000004
Figure PCTCN2018123837-appb-000005
*实施例Ⅰ-Ⅹ中去屑止痒复合活性物各组分剂含量(重量比)为：含20％的有机酸锌混合物，该有机酸锌混合物是葡萄糖酸锌︰乳酸锌︰吡咯烷酮羧酸锌:甘草亭酸锌以重量比1：1︰1:0.2的比例混合；含2％的核桃壳提取物；含16.6％的氧化锌，该氧化锌粒径为0.05μm，比表面积为80m 2/g；含1％的苯氧乙醇；含5％的改性淀粉以及余量的水。
本发明空白对照实施例(表4)
Figure PCTCN2018123837-appb-000006
Figure PCTCN2018123837-appb-000007
感官理化指标
5.3.4检测标准
本发明香波组合物检测标准符合国标GB/T 29679洗发露，具体详见表5所示。
表5感官、理化、卫生指标
Figure PCTCN2018123837-appb-000008
Figure PCTCN2018123837-appb-000009
氧化锌抑菌实验
抑菌测试及实验方法
抑菌效力的测定—牛津杯法，此方法是国内外检验抗生素效价的通用方法，也是各国药典规定的方法。将含有定量抑菌药物的牛津杯放在已接种待检菌的琼脂平板上，牛津杯中所含的药物不断向牛津杯周围扩散，形成递减的梯度浓度。在牛津杯周围抑菌浓度范围内待检菌的生长被抑制，形成无菌生长的透明圈(即抑菌圈)。抑菌圈的大小反映待检菌对测定药物的敏感程度，并与该药对待检菌的最低(或最小)抑菌浓度(minimal inhibitory concentration，MIC)呈负相关关系，即抑菌圈越大，MIC越小，它的抑菌效果也就越强。
菌株：糠枇马拉色菌ATCC44344。菌种由广东微生物菌种保藏中心购买。
培养基配制：培养基按配方称量好后有适量去离子水溶解，振荡摇匀，再加水至所需体积。
抑菌效力的测定：将培养基摇匀后倾注平板，冷却凝固，每个平板15mL左右。将一定比例的菌悬液滴加于平板上，用涂布棒在平板表面均匀涂抹3次。盖好平皿，置室温干燥5min。用镊子将内径为6mm的牛津杯用镊子轻放在已经凝固的培养基上。用1mL的一次性注射针头吸取样品，加入牛津杯中，每个杯中大约加250μL样品。在适宜的温度下培养一定时间后，观察抑菌圈的大小或用游标卡尺测定抑菌圈直径。测量抑菌环时，应选均匀而完全无菌生长的抑菌环进行。测量其直径应以抑菌环外沿为界。
大比表面积氧化锌样品参数：比表面积大于等于80m 2/g，粒径大于等于0.05μm。
实验方法
(1)氧化锌(大比表面积)样品分散在丙酮当中(ZnO 25％含量),然后分别稀释成0.16-2.5％浓度的氧化锌分散溶液备用，其中空白对照(不含ZnO)样品分别为水和丙酮。
(2)将培养基配备好(见表6)，然后将皮屑芽孢菌置入培养基中，将水，丙酮，含量分别为小于0.16％，0.16％，0.3％，0.6％，1.25％，2.5％浓度的丙酮分散溶液，以及含1.5％ZPT的丙酮分散液等分别置入含有糠枇马拉色菌(皮屑芽孢菌)的培养基，然后在有氧条件下，37℃培养3天，观察皮屑芽孢菌的生长情况(见表7)。
培养基表6
Figure PCTCN2018123837-appb-000010
Figure PCTCN2018123837-appb-000011
表6，将培养基按配方称量好后有适量去离子水溶解，振荡摇匀，再加水至所需体积。将锥形瓶放到电磁炉上加热搅拌，直至培养基溶液微沸，并保持此状态5-10min。放入灭菌锅中于121℃下灭菌20分钟，待冷却至60℃时取出，如没有染菌则可用。
抑菌实验-表7
Figure PCTCN2018123837-appb-000012
表7结果显示，两个空白对照样品(不含氧化锌)和大比表面积氧化锌含量<0.16％的样品均观察不到抑菌圈的形成，说明所述三个样品不具有抑制糠枇马拉色菌(皮屑芽孢菌)生长的效果；而大比表面积氧化锌含量分别为0.16％，0.3％，0.6％，1.25％，2.5％的牛津杯周围抑菌浓度范围内待检菌的生长被抑制，形成无菌生长的透明圈(即抑菌圈)，且抑菌圈呈现从小到大趋势；1.5％ZPT亦可观察到明显的抑菌圈的形成且与含量2.5％大比表面积氧化锌所形成的抑菌圈大小近似。
氧化锌最小抑菌浓度(MIC)
将医药级氧化锌和大比表面积氧化锌分别分别悬浮于丙酮中，分别制成浓度从最低浓度90PPM到6000PPM的悬浮液，并分成等分放入培养基进行培养，最终观察马拉色菌被抑制的最低浓度MIC，见表8。
表8.
Figure PCTCN2018123837-appb-000013
以上表格8可以得出：大比表面积氧化锌比医药级氧化锌具有更低的抑菌(皮屑芽孢菌)浓度，说明大比表面积氧化锌的抑菌效果更强。
本发明香波组合物去屑止痒临床实验
测试方法：选择60位有中度头皮屑和头痒的志愿者，要求无脂溢性皮炎、无过敏、无伤口的头皮健康患者，试用前，对患者进行感官和头发图像评估，让患者使用本发明的最佳实施例香波和本发明空白实施例香波，持续使用(按照日常使用频率使用样品)，第14天(两周)后停止使用，停止使用后的第12 小时，第24小时和第48小时分别观察头屑和头痒的状况，进行评分，综合评估见表9。
志愿者皮肤的使用前后的打分，1，2，3，4，5分，分数越高效果越好：1-2：无效；2-3：中等；3-4：好；4-5：非常好。
志愿者使用该产品前后志愿者的头发感官评估。表9
Figure PCTCN2018123837-appb-000014
表9中头皮屑减少与头痒减少统计来看，本发明最佳实施例的无效百分比明显低于本发明空白对照实施例。

Claims (5)

  1. 一种含多元锌的去屑止痒香波组合物，除水外，还含有：
    (A)占组合物重量5.0％至40％的阴离子表面活性剂；
    (B)占组合物重量1.0％至10.0％的椰油两性醋酸钠和烷基葡糖苷的组合物；
    (C)占组合物重量0.1％至30％含有多元锌头皮去屑止痒复合活性物，所述多元锌去屑止痒复合活性物是由以下组分组成：
    占复合活性物重量10-30％的有机酸锌混合物，该有机酸锌混合物是葡萄糖酸锌︰乳酸锌︰吡咯烷酮羧酸锌：甘草亭酸锌，并以重量比1：1︰1：0.2的比例混合；
    占复合活性物重量1-20％的无机锌，该无机锌为氧化锌，且该氧化锌粒径为0.01μm-100μm；比表面积为30-100m 2/g；
    占复合活性物重量0.01-5％的核桃壳提取物；
    占复合活性物重量1-10％的悬浮剂，该悬浮剂为改性淀粉；
    占复合活性物重量0.5-1％的苯氧乙醇；
    及余量的水；
    (D)占组合物重量0.05-2.0％的阳离子聚合物。
  2. 根据权利要求1所述的香波组合物，其中的氧化锌粒径为0.1μm-30μm；比表面积为50-90m 2/g。
  3. 根据权利要求1所述的香波组合物，其中所述阴离子表面活性剂选自：烷基硫酸酯盐、烷基聚氧乙烯醚硫酸酯盐、脂肪酸单甘油酯硫酸盐、烷基磺酸盐、椰油 羟乙基磺酸盐、α-烯烃磺酸钠、N-酰肌氨酸盐、N-酰谷氨酸盐、烷基磷酸酯盐中的至少一种。
  4. 根据权利要求1所述的香波组合物，其中所述椰油两性醋酸钠和烷基葡糖苷的比例为1:1。
  5. 根据权利要求1所述的香波组合物，其中所述阳离子聚合物选自：阳离子纤维素聚合物或阳离子瓜尔胶聚合物。
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