WO2020124658A1 - Non-invasive anti-interference blood glucose measuring instrument and blood glucose measuring method therefor - Google Patents

Non-invasive anti-interference blood glucose measuring instrument and blood glucose measuring method therefor Download PDF

Info

Publication number
WO2020124658A1
WO2020124658A1 PCT/CN2018/124207 CN2018124207W WO2020124658A1 WO 2020124658 A1 WO2020124658 A1 WO 2020124658A1 CN 2018124207 W CN2018124207 W CN 2018124207W WO 2020124658 A1 WO2020124658 A1 WO 2020124658A1
Authority
WO
WIPO (PCT)
Prior art keywords
electrode
blood glucose
data
circuit
interference
Prior art date
Application number
PCT/CN2018/124207
Other languages
French (fr)
Chinese (zh)
Inventor
江昱莹
廖睿禾
Original Assignee
林少玉
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 林少玉 filed Critical 林少玉
Publication of WO2020124658A1 publication Critical patent/WO2020124658A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7203Signal processing specially adapted for physiological signals or for diagnostic purposes for noise prevention, reduction or removal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7225Details of analog processing, e.g. isolation amplifier, gain or sensitivity adjustment, filtering, baseline or drift compensation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/72Signal processing specially adapted for physiological signals or for diagnostic purposes
    • A61B5/7235Details of waveform analysis
    • A61B5/725Details of waveform analysis using specific filters therefor, e.g. Kalman or adaptive filters

Definitions

  • the invention relates to the field of medical equipment, in particular to a non-invasive anti-interference blood glucose detector and a method for detecting blood glucose.
  • this non-invasive blood glucose tester only detects electronic data. Before there is no actual data calibration method, these electronic data are lack of authenticity, and the real blood glucose value of the human body cannot be directly calculated.
  • various home blood glucose meters whether they are non-invasive or blood-binding, claim to be able to detect blood glucose values, but can only actually measure electronic data. Their accuracy is very different from the real blood glucose value, and their accuracy is greater than ⁇ 20 % Error. Taking the user's actual blood glucose value as 6.5, for example, an error of ⁇ 20% has caused the measured value to fluctuate between 5.2-7.8. Such a large floating range has caused some risk groups that are only high blood sugar to be misdiagnosed as diabetic patients, or some diabetic patients are misdiagnosed as dangerous people and delay treatment.
  • the technical problem to be solved by the present invention is to provide a non-invasive anti-interference blood glucose detector and a method for detecting blood glucose, which can reduce external interference and capture more accurate data through rational design of electrodes and circuits. At the same time, through a scientific calibration method, a more real blood glucose value is measured.
  • the present invention adopts the following technical solutions:
  • a non-invasive anti-interference blood glucose detector includes a first electrode, a second electrode, a third electrode, and a fourth electrode made of a conductor exposed outside the housing; and a working circuit;
  • the first electrode, the third electrode and the fourth electrode are provided at one end of the casing to form a first probe, and the second electrode is separately provided at the other end of the casing to form a second probe;
  • the first electrode is connected to the second electrode , Used to form a loop at two different locations that contact the human body to measure data;
  • the third electrode is connected to the fourth electrode to form a loop at the first probe to contact the human body to measure the contact between the first probe and the human body Interfere with data;
  • the working circuit includes:
  • the signal processing module is used to filter and adjust the data intercepted by each electrode
  • the storage unit is used to store the data of the user's blood test for the first correction
  • Microprocessor used to calculate the data obtained by the signal processing module
  • the first electrode, the second electrode, the third electrode, and the fourth electrode are connected to the signal processing module, the microprocessor is connected to the signal processing module, the storage unit is connected to the microprocessor, and the power module supplies power to each component through the circuit.
  • the signal processing module includes a signal filtering circuit, a signal amplifying circuit and a conversion circuit; the signal filtering circuit and the signal amplifying circuit are connected to two of the first electrode and the second electrode, the third electrode and the fourth electrode On the loop; the conversion circuit is connected to the signal amplification circuit, and the microprocessor is connected to the conversion circuit.
  • a first capacitor and a second capacitor are connected between the signal filtering circuit and the signal amplifying circuit, and are used to store the signal current formed by the loop after being filtered and rectified by the signal filtering circuit.
  • two middle conductors are respectively provided on the first probe, and a ring conductor is provided on the periphery of the two middle conductors, which serve as the first electrode, the third electrode, and the fourth electrode, respectively.
  • the display unit for outputting data processing results; the display unit is connected to the microprocessor and exposed to the casing.
  • the input unit for inputting the data of the blood drawn by the user to the storage unit, and the input unit is connected to the microprocessor.
  • a non-invasive anti-interference method for detecting blood glucose including the following steps:
  • step S02 the blood glucose value of the user is detected by means of a hospital blood test, and the corrected blood glucose value is stored, and the data obtained in step S01 is used as the corrected data to match the corrected blood glucose value;
  • step S01 When it is necessary to detect the blood glucose value, repeat step S01, compare the measured data at that time with the corrected data and corrected blood glucose value obtained at step S02, and obtain the user's instant blood glucose value at that time.
  • step S01 specifically includes:
  • the microprocessor processes and calculates the electronic data of the measurement circuit and the electronic data of the deduction circuit to obtain high-precision data after deducting contact interference, and stores the data;
  • the current I 1 drawn by the first electrode and the current I 1 +I 2 drawn by the first electrode and the third electrode are stored in the first capacitor and the second capacitor respectively , And then discharge the electricity of the first capacitor and the second capacitor separately to obtain the electronic data of the measurement circuit and the deduction circuit respectively.
  • step S012 is repeatedly executed at a certain time interval before step S013, and the data with the most repetitions is taken as the electronic data of the measurement loop.
  • steps S011 to S014 are executed, after stimulating the user for 0.8-1.1 seconds in step S01, steps S012 to S014 are repeated multiple times to obtain stable and high-precision electronic data.
  • pre-processing step S00 which has the following steps
  • the instant blood glucose value obtained in step S03 is compared with the database established in step S002 to obtain the user's status.
  • the non-intrusive anti-interference blood glucose detector provided by the present invention by designing multiple electrodes to form multiple loops, can reduce the interference of the external environment during the measurement process by means of data deduction and make the detected data more accurate. And the design of the loop has the function of signal amplification and filtering, which further improves the sensitivity and accuracy of data detection.
  • the invention also provides a non-invasive anti-interference method for detecting blood glucose, which adopts a more advanced multi-electrode measurement method to avoid interference and obtain more accurate data. And has a scientific data calibration method, so as to match the true and accurate blood glucose values.
  • FIG. 1 is a schematic diagram of the external structure of a non-invasive anti-interference blood glucose detector provided by the present invention.
  • Figure 2 is a schematic diagram of the internal circuit structure.
  • Figure 3 is a schematic diagram of the circuit formed by the electrode and the human body.
  • the second probe 4. The first electrode
  • an embodiment of the present invention provides a non-invasive anti-interference blood glucose detector, which includes a first electrode 4, a second electrode 5 and a third electrode made of a conductor exposed outside the housing 1 Electrode 6 and fourth electrode 7; and working circuit;
  • the first electrode 4, the third electrode 6 and the fourth electrode 7 are provided at one end of the casing 1 to form a first probe 2, and the second electrode 5 is separately provided at the other end of the casing 1 to form a second probe 3;
  • the first electrode 4 is connected to the second electrode 5 for contacting two different positions of the human body to form a loop to measure data;
  • the third electrode 6 is connected to the fourth electrode 7 for contacting the human body at the first probe 2 to form a loop To measure the interference data at the contact between the first probe 2 and the human body;
  • the working circuit includes:
  • the signal processing module 9 is used to filter and adjust the data intercepted by each electrode
  • the storage unit 10 is used to store the data of the user's blood test for the first correction
  • the microprocessor 11 is used to calculate the data obtained by the signal processing module 9;
  • Power module 12 used for power supply of all components
  • the first electrode 4, the second electrode 5, the third electrode 6, and the fourth electrode 7 are connected to the signal processing module 9, the microprocessor 11 is connected to the signal processing module 9, the storage unit 10 is connected to the microprocessor 11, and the power module 12 Provide power to each component through the circuit.
  • the present invention does not simply use two electrodes to form a loop with the human body to detect blood glucose data, but uses four electrodes distributed on two probes to form multiple circuits with the human body to achieve interference data deduction
  • the subtraction operation function makes the detection data more accurate.
  • each electrode is shown in Figure 3.
  • the four electrodes are respectively arranged on two probes and contact different positions of the human body.
  • the first probe 2 contacts the palm of a person and the second probe 3 contacts the thumb of the other hand.
  • the first electrode 4 provided on the first probe 2 and the second electrode 5 provided on the second probe 3 form a loop, which can be energized to detect electronic data without intrusion.
  • the third electrode 6 and the fourth electrode 7 are provided at the first probe 2 to form a loop, and a deduction loop is formed at the contact point of the palm, which is specially used to detect and reduce external interference near the contact point.
  • the present invention also provides a storage unit 10 in the circuit, which is used to store the real blood glucose value measured by the user by blood drawing and the electronic data measured by the electrode, so as to achieve data calibration. Therefore, the present invention does not simply measure electronic signals.
  • the specific calibration method will be described in detail in the blood glucose detection method below.
  • buttons, switches and the like may be installed on the housing 1 to realize various control functions.
  • these components are not the technical focus of the present invention and are not much related to the technical solution, and will not be repeated in the present invention.
  • this structure is omitted in the drawings of the specification.
  • the signal processing module 9 includes a signal filtering circuit 13, a signal amplifying circuit 14 and a conversion circuit 15; the signal filtering circuit 13 and the signal amplifying circuit 14 are connected to the first electrode 4 and the second electrode 5, the third The two circuits composed of the electrode 6 and the fourth electrode 7 are connected; the conversion circuit 15 is connected to the signal amplifying circuit 14, and the microprocessor 11 is connected to the conversion circuit 15.
  • the signal amplifying circuit 14 is used to receive and amplify the electrical signals transmitted by the electrodes, so that the weak electrical signals are more sensitive after amplification.
  • the signal filtering circuit 13 is used for rectifying and filtering noise to obtain a clean signal.
  • the conversion circuit 15 is used to convert an analog signal into a digital signal.
  • a first capacitor 16 and a second capacitor 17 are connected between the signal filtering circuit 13 and the signal amplifying circuit 14 for storing the signal current formed by the loop after being filtered and rectified by the signal filtering circuit 13 and stored therein .
  • the first probe 2 is respectively provided with two middle conductors, and a ring conductor is provided on the outer periphery of the two middle conductors as the first electrode 4, the third electrode 6 and the fourth electrode 7, respectively.
  • the third electrode 6 or the fourth electrode 7 is not actually the technical focus of the present invention.
  • the main purpose of setting three electrodes on the first probe 2 is to eliminate contact interference and improve data collection accuracy. Therefore, the arrangement of the first electrode 4, the third electrode 6, and the fourth electrode 7 is not excessively limited without departing from this design goal.
  • the display unit 8 for outputting data processing results; the display unit 8 is connected to the microprocessor 11 and exposed to the housing 1. It also includes an input unit for inputting data of the user's blood test to the storage unit 10, and the input unit is connected to the microprocessor 11.
  • the present invention does not have the display unit 8 and displays the result by means of signal transmission to an external display device.
  • the present invention does not have an input unit, and it is also a feasible solution to input data to the storage unit 10 by wireless or wired transmission by an external device.
  • the present invention provides a non-invasive anti-interference blood glucose detector.
  • multiple electrodes to form multiple circuits, the interference of the external environment during the detection process can be reduced by data deduction, and the detected data is more accurate.
  • the design of the loop has the function of signal amplification and filtering, which further improves the sensitivity and accuracy of data detection.
  • This embodiment details a non-invasive anti-interference blood glucose detection method, and its essence is also the working process of the non-invasive anti-interference blood glucose detector described in the first embodiment.
  • a non-invasive anti-interference method for detecting blood glucose including the following steps:
  • step S02 the blood glucose value of the user is detected by means of a hospital blood test, and the corrected blood glucose value is stored, and the data obtained in step S01 is used as the corrected data to match the corrected blood glucose value;
  • step S01 When it is necessary to detect the blood glucose value, repeat step S01, compare the measured data at that time with the corrected data and corrected blood glucose value obtained at step S02, and obtain the user's instant blood glucose value at that time.
  • This method advocates calibration and matching calculation with the real blood glucose value measured by blood drawing. Therefore, the detection of blood glucose value is not just a simple electronic data, but a value that actually matches the blood glucose value of the human body. This method is scientific and reasonable, and has high accuracy, which helps to accurately determine the blood glucose situation of the user and will not delay the diagnosis and treatment.
  • step S02 the present invention devises a calibration process, that is, step S02 needs to be implemented, and the user's real blood glucose value is measured by way of blood sampling in the hospital and input into the blood glucose meter.
  • non-intrusive detection through normal electrodes is used to intercept high-precision electronic data, which can be matched with the real blood glucose value measured in step S02 to achieve calibration.
  • This process is actually a learning process carried out by the blood glucose detector according to the actual physical condition of the user.
  • a data matching system can be constructed to know the blood glucose value corresponding to different electronic data. Even, a database can be established to match the corresponding blood glucose level to inform the user of his physical condition.
  • the above-mentioned process of calibrating the blood drawn blood glucose value is an important technical breakthrough of the method of the present invention.
  • the electronic data detected by electronic methods even if the accuracy is high, is only a set of electronic data, not real blood glucose data. Even the widely used blood-gathering blood glucose meter at home is easily affected by impurities, blood concentration, and whether the blood reacts adequately in the instrument, etc., resulting in distortion of blood glucose value.
  • the blood glucose value measured by the instrument is accurate only when the method of blood sampling in the hospital is used to detect the blood glucose value and the real blood glucose value is obtained for comparison and calibration.
  • the current value is 100 mA
  • the blood glucose value corresponding to the electronic data is known.
  • the current value became 150 mA.
  • the formula for calculating the blood glucose value is written in the microprocessor 11, and the corresponding blood glucose value at the time of occurrence can be calculated by the formula.
  • step S01 further specifically includes:
  • the microprocessor 11 processes and calculates the electronic data of the measurement circuit and the electronic data of the deduction circuit to obtain high-precision data after deducting contact interference, and stores the data;
  • steps S011 to S014 are actually steps for realizing non-invasive detection of electrodes by using a blood glucose detector, which specifically describes the process of intercepting data by energizing four electrodes and a method of reducing external interference.
  • the process of using a blood glucose tester for blood glucose testing everyday is to repeat the process of step S01.
  • the current I 1 drawn by the first electrode 4 and the current I 1 +I 2 drawn by the first electrode 4 and the third electrode 6 are stored in the first capacitor In the 16 and the second capacitor 17, the electrical energy of the first capacitor 16 and the second capacitor 17 are then discharged to obtain the electronic data of the measurement circuit and the deduction circuit, respectively.
  • the data can be repeatedly intercepted in certain steps, and valid data can be selected for calculation to further improve the accuracy of the detected data.
  • the step S012 is repeatedly executed at a certain time interval before step S013, and the data with the most repetitions is taken as the electronic data of the measurement loop.
  • the first electrode 4 delivers a minute current I 1 to the human body every 0.1 seconds
  • the third electrode 6 delivers a tiny current I 2 to the human body every 0.5 seconds.
  • the first electrode 4 performed current energization detection multiple times (that is, the step S02 was repeatedly performed multiple times), and the data with the most repetitions could be captured as the electronic data of the measurement loop.
  • the first electrode 4 and the third electrode 6 draw current at the same time, and the current value used in the calculation is the sum of I 1 +I 2 .
  • steps S011 to S014 are executed, after step S011 stimulates the user for 0.8-1.1 seconds, steps S012 to S014 are executed again, which is beneficial to obtain stable electronic data.
  • steps S011 to S014 are executed, steps S012 to S014 are repeatedly executed multiple times to take the high-precision data with the most repetitions.
  • a pre-processing step S00 which has the following steps,
  • the instant blood glucose value obtained in step S03 is compared with the database established in step S002 to obtain the user's status.
  • the tolerance value can be selected to be ⁇ 10%, and the interval value is determined:
  • the instant blood glucose value measured in step S03 can be directly compared with the blood glucose value interval, and immediately know which state the user is in, which is convenient for the doctor to track the treatment and adjust the medication. Because the electronic signal is very weak, everyone's response to the electronic will also be different. By correcting the type of user first, and then supplementing with a certain percentage of probability errors to narrow the range to approximate accuracy.
  • the invention provides a non-invasive anti-interference method for detecting blood glucose, which adopts a more advanced multi-electrode measurement method to avoid interference and obtain more accurate data. And has a scientific data calibration method, so as to match the true and accurate blood glucose values.

Abstract

Disclosed is a non-invasive anti-interference blood glucose measuring instrument, comprising a first electrode (4), a second electrode (5), a third electrode (6) and a fourth electrode (7) exposed from a housing (1) and composed of conductors, and an operating circuit, wherein the first electrode (4), the third electrode (6) and the fourth electrode (7) are arranged on one end of the housing (1) to constitute a first probe (2), the second electrode (5) is individually arranged on the other end of the housing (1) to constitute a second probe (3), the first electrode (4) is connected to the second electrode (5), and the third electrode (6) is connected to the fourth electrode (7); and the working circuit comprises: a signal processing module (9), a storage unit (10), a microprocessor (11) and a power supply module (12). The first electrode (4), the second electrode (5), the third electrode (6) and the fourth electrode (7) are connected to the signal processing module (9), the microprocessor (11) is connected to the signal processing module (9), the storage unit (10) is connected to the microprocessor (11), and the power supply module (12) powers various elements by means of a circuit. The non-invasive anti-interference blood glucose measuring instrument can reduce external interference, capture more accurate data and measure a more accurate and real blood glucose value.

Description

一种非侵入式抗干扰血糖检测仪及其检测血糖的方法Non-invasive anti-interference blood glucose detector and method for detecting blood glucose 技术领域Technical field
本发明涉及医疗器械领域,具体涉及一种非侵入式抗干扰血糖检测仪及其检测血糖的方法。The invention relates to the field of medical equipment, in particular to a non-invasive anti-interference blood glucose detector and a method for detecting blood glucose.
背景技术Background technique
目前,世界各国已经开始关注非侵入性(免扎血)血糖检测仪的技术研发,一般是采用电子技术通过人体的皮肤对获取人体的生理数据。这些悉知的单一电子技术虽然是可以看到皮肤的电子讯号变化,但经实验发现,这些变化非常细微且极容易受到外在环境的干扰,因此检测的数据准确度无法保证,欠缺实际意义。At present, countries around the world have begun to pay attention to the research and development of non-invasive (no-blood blood) blood glucose detector technology. Generally, electronic technology is used to obtain physiological data of the human body through the human skin. Although these known single electronic technologies can see the changes in the skin's electronic signals, it has been found through experiments that these changes are very subtle and extremely susceptible to interference from the external environment. Therefore, the accuracy of the detected data cannot be guaranteed and lacks practical significance.
而且,这种非侵入式的血糖检测仪所检测的仅仅是电子数据,在没有实际的数据校准手段之前,这些电子数据是欠缺真实性的,无法直接计算出人体真实的血糖值。目前各种家用血糖仪,无论是非侵入式抑或是扎血式的,宣称能够检测血糖值,实际仅仅能够测出电子数据,其准确性与真实血糖值有很大误差,其精度具有大于±20%的误差。以使用者的真实为血糖值6.5为例,±20%的误差已经导致测量值在5.2-7.8之间浮动。这么大的浮动区间已经导致一些仅仅是血糖高的危险群被误诊为糖尿病患者、或一些糖尿病患者被误诊为危险人群而耽误治疗。Moreover, this non-invasive blood glucose tester only detects electronic data. Before there is no actual data calibration method, these electronic data are lack of authenticity, and the real blood glucose value of the human body cannot be directly calculated. At present, various home blood glucose meters, whether they are non-invasive or blood-binding, claim to be able to detect blood glucose values, but can only actually measure electronic data. Their accuracy is very different from the real blood glucose value, and their accuracy is greater than ±20 % Error. Taking the user's actual blood glucose value as 6.5, for example, an error of ±20% has caused the measured value to fluctuate between 5.2-7.8. Such a large floating range has caused some risk groups that are only high blood sugar to be misdiagnosed as diabetic patients, or some diabetic patients are misdiagnosed as dangerous people and delay treatment.
技术问题technical problem
所以目前完全无一有效可以做出真正产品的非侵入型的血糖检测仪。Therefore, there is no effective non-invasive blood glucose detector that can make a real product.
不难看出,现有技术还存在一定的缺陷。It is not difficult to see that the existing technology still has certain defects.
技术解决方案Technical solution
本发明所要解决的技术问题是提供一种非侵入式抗干扰血糖检测仪及其检测血糖的方法,能够通过电极及电路的合理设计,降低外界干扰,抓取更准确的数据。同时,通过科学的校准方式,测得更真实的血糖值。The technical problem to be solved by the present invention is to provide a non-invasive anti-interference blood glucose detector and a method for detecting blood glucose, which can reduce external interference and capture more accurate data through rational design of electrodes and circuits. At the same time, through a scientific calibration method, a more real blood glucose value is measured.
为实现上述目的,本发明采用以下技术方案:To achieve the above objectives, the present invention adopts the following technical solutions:
一种非侵入式抗干扰血糖检测仪,包括外露于壳体之外的由导体构成的第一电极、第二电极、第三电极和第四电极;以及工作电路;A non-invasive anti-interference blood glucose detector includes a first electrode, a second electrode, a third electrode, and a fourth electrode made of a conductor exposed outside the housing; and a working circuit;
其中,第一电极、第三电极及第四电极设于壳体的一端组成一个第一探头,第二电极单独设于壳体的另一端组成一个第二探头;第一电极与第二电极连接,用于接触人体的两个不同位置构成回路,以测量数据;第三电极与第四电极连接,用于在第一探头处接触人体构成回路,以测量第一探头与人体的触点处的干扰数据;Among them, the first electrode, the third electrode and the fourth electrode are provided at one end of the casing to form a first probe, and the second electrode is separately provided at the other end of the casing to form a second probe; the first electrode is connected to the second electrode , Used to form a loop at two different locations that contact the human body to measure data; the third electrode is connected to the fourth electrode to form a loop at the first probe to contact the human body to measure the contact between the first probe and the human body Interfere with data;
其中,工作电路包括:Among them, the working circuit includes:
讯号处理模块,用于过滤调整各电极截得的数据;The signal processing module is used to filter and adjust the data intercepted by each electrode;
存储单元,用于存储使用者抽血检测的数据作首次校正;The storage unit is used to store the data of the user's blood test for the first correction;
微处理器,用于运算处理讯号处理模块获得的数据;Microprocessor, used to calculate the data obtained by the signal processing module;
电源模组,用于所有元件的供电;Power module for power supply of all components;
第一电极、第二电极、第三电极及第四电极与讯号处理模块连接,微处理器与讯号处理模块连接,存储单元与微处理器连接,电源模组通过电路对各元件实现供电。The first electrode, the second electrode, the third electrode, and the fourth electrode are connected to the signal processing module, the microprocessor is connected to the signal processing module, the storage unit is connected to the microprocessor, and the power module supplies power to each component through the circuit.
进一步的,所述讯号处理模块包括讯号滤波电路、讯号放大电路和转换电路;讯号滤波电路、讯号放大电路均连接于由第一电极与第二电极、由第三电极与第四电极组成的两条回路上;转换电路与讯号放大电路连接,微处理器与转换电路连接。Further, the signal processing module includes a signal filtering circuit, a signal amplifying circuit and a conversion circuit; the signal filtering circuit and the signal amplifying circuit are connected to two of the first electrode and the second electrode, the third electrode and the fourth electrode On the loop; the conversion circuit is connected to the signal amplification circuit, and the microprocessor is connected to the conversion circuit.
进一步的,所述讯号滤波电路与讯号放大电路之间连接有第一电容及第二电容,用于将回路形成的讯号电流,经过讯号滤波电路滤波整流后存入其中。Further, a first capacitor and a second capacitor are connected between the signal filtering circuit and the signal amplifying circuit, and are used to store the signal current formed by the loop after being filtered and rectified by the signal filtering circuit.
进一步的,所述第一探头上分别设有两个中部导体,两中部导体的外围设有一个环形导体,分别作为第一电极、第三电极和第四电极。Further, two middle conductors are respectively provided on the first probe, and a ring conductor is provided on the periphery of the two middle conductors, which serve as the first electrode, the third electrode, and the fourth electrode, respectively.
进一步的,还包括显示单元,用于输出数据处理的结果;显示单元与微处理器连接,且外露于壳体。Further, it also includes a display unit for outputting data processing results; the display unit is connected to the microprocessor and exposed to the casing.
进一步的,还包括输入单元,用于输入使用者抽血检测的数据到存储单元,输入单元与微处理器连接。Further, it also includes an input unit for inputting the data of the blood drawn by the user to the storage unit, and the input unit is connected to the microprocessor.
一种非侵入式抗干扰的检测血糖方法,包括以下步骤:A non-invasive anti-interference method for detecting blood glucose, including the following steps:
S01、使带有电极的第一探头与带有电极的第二探头分别接触人体的不同位置形成回路,往第一探头上的电极打出电流,检测电子数据,计算并存储到存储单元中;S01. Make the first probe with electrodes and the second probe with electrodes respectively contact different positions of the human body to form a loop, draw current to the electrodes on the first probe, detect electronic data, calculate and store in the storage unit;
S02、随后采用医院抽血检测的方式对使用者的血糖值进行检测,并将检测的校正血糖值储存,以步骤S01获得的数据作为校正数据与校正血糖值匹配;S02. Subsequently, the blood glucose value of the user is detected by means of a hospital blood test, and the corrected blood glucose value is stored, and the data obtained in step S01 is used as the corrected data to match the corrected blood glucose value;
S03、需要检测血糖值时,重复步骤S01,将该时刻测得的数据作为即时数据,与步骤S02获得的校正数据及校正血糖值进行比对计算,获得该时刻使用者的即时血糖值。S03. When it is necessary to detect the blood glucose value, repeat step S01, compare the measured data at that time with the corrected data and corrected blood glucose value obtained at step S02, and obtain the user's instant blood glucose value at that time.
进一步的,所述步骤S01具体包括:Further, the step S01 specifically includes:
S011、使带有第一电极、第三电极及第四电极的第一探头与带有第二电极的第二探头分别接触人体的不同位置;使第一电极及第二电极与人体组成测量回路;使第三电极及第四电极与人体在第一探头的触点处组成扣减回路;S011. Make the first probe with the first electrode, the third electrode and the fourth electrode and the second probe with the second electrode contact different positions of the human body; make the first electrode, the second electrode and the human body form a measurement circuit ; Make the third electrode and the fourth electrode and the human body form a deduction loop at the contact point of the first probe;
S012、往第一电极通电打出电流I 1,并通过电流I 1检测测量回路的电子数据; S012. Energize the first electrode to draw a current I 1 , and detect the electronic data of the measurement loop through the current I 1 ;
S013、往第一电极通电打出电流I 1的同时,往第三电极通电打出电流I 2,并通过总电流I 1+I 2检测扣减回路的电子数据; S013. While the first electrode is energized to draw a current I 1 , the third electrode is energized to draw a current I 2 , and the electronic data of the deduction circuit is detected by the total current I 1 +I 2 ;
S014、微处理器将测量回路的电子数据与扣减回路的电子数据进行处理计算,获得扣减掉触点干扰后的高精度数据,并储存;S014. The microprocessor processes and calculates the electronic data of the measurement circuit and the electronic data of the deduction circuit to obtain high-precision data after deducting contact interference, and stores the data;
进一步的,所述步骤S012至S013中,第一电极通电打出的电流I 1、以及第一电极和第三电极同时通电打出的电流I 1+I 2,分别存入第一电容及第二电容中,然后分别放电取出第一电容及第二电容的电量,分别获得测量回路和扣减回路的电子数据。 Further, in the steps S012 to S013, the current I 1 drawn by the first electrode and the current I 1 +I 2 drawn by the first electrode and the third electrode are stored in the first capacitor and the second capacitor respectively , And then discharge the electricity of the first capacitor and the second capacitor separately to obtain the electronic data of the measurement circuit and the deduction circuit respectively.
进一步的,每当执行步骤S011至S014时,所述步骤S012在步骤S013之前以一定时间间隔重复执行多次,取重复次数最多的数据作为测量回路的电子数据。Further, whenever steps S011 to S014 are executed, the step S012 is repeatedly executed at a certain time interval before step S013, and the data with the most repetitions is taken as the electronic data of the measurement loop.
进一步的,每当执行步骤S011至S014时,在步骤S01刺激使用者0.8-1.1秒后,再重复多次执行步骤S012至S014,以获得稳定、高精度的电子数据。Further, whenever steps S011 to S014 are executed, after stimulating the user for 0.8-1.1 seconds in step S01, steps S012 to S014 are repeated multiple times to obtain stable and high-precision electronic data.
进一步的,在所有步骤前,具有一个预处理步骤S00,其具有如下步骤,Further, before all the steps, there is a pre-processing step S00, which has the following steps,
S001、按血糖值高低的严重程度对不同高低的血糖值进行分类;S001. Classify the blood glucose levels of different levels according to the severity of the blood glucose level;
S002、在不同分类的标准血糖值的基础上,按照正负容差计算出各分类的区间值,建立起不同分类的数值区间的数据库;S002. Based on the standard blood glucose values of different categories, calculate the interval values of each category according to the positive and negative tolerances, and establish a database of numerical intervals of different categories;
步骤S03获得的即时血糖值与步骤S002中建立的数据库进行比对,获得使用者的状态。The instant blood glucose value obtained in step S03 is compared with the database established in step S002 to obtain the user's status.
有益效果Beneficial effect
本发明提供的一种非侵入式抗干扰血糖检测仪,通过设计多个电极组成多个回路,从而可以通过数据扣减的方式抵降低测过程中外界环境的干扰,使检测的数据更精准。且回路的设计具有讯号放大及过滤的功能,进一步提高数据检测的灵敏度及准确性。The non-intrusive anti-interference blood glucose detector provided by the present invention, by designing multiple electrodes to form multiple loops, can reduce the interference of the external environment during the measurement process by means of data deduction and make the detected data more accurate. And the design of the loop has the function of signal amplification and filtering, which further improves the sensitivity and accuracy of data detection.
本发明还提供的一种非侵入式抗干扰的检测血糖方法,采用更先进的多电极测量方法,避免干扰,测得更精准的数据。且具有科学的数据校准方法,从而匹配出真实准确的血糖值。 The invention also provides a non-invasive anti-interference method for detecting blood glucose, which adopts a more advanced multi-electrode measurement method to avoid interference and obtain more accurate data. And has a scientific data calibration method, so as to match the true and accurate blood glucose values.
附图说明BRIEF DESCRIPTION
为了更清楚地说明本发明实施例或现有技术中的技术方案,下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本发明的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他的附图。In order to more clearly explain the embodiments of the present invention or the technical solutions in the prior art, the following will briefly introduce the drawings required in the embodiments or the description of the prior art. Obviously, the drawings in the following description are only These are some embodiments of the present invention. For those of ordinary skill in the art, without paying any creative labor, other drawings can be obtained based on these drawings.
图1为本发明提供的一种非侵入式抗干扰血糖检测仪外部结构示意图。FIG. 1 is a schematic diagram of the external structure of a non-invasive anti-interference blood glucose detector provided by the present invention.
图2为内部电路结构示意图。Figure 2 is a schematic diagram of the internal circuit structure.
图3为电极与人体组成的回路示意图。Figure 3 is a schematic diagram of the circuit formed by the electrode and the human body.
附图标记说明:Description of reference signs:
1、壳体                         2、第一探头1. Housing: 2. The first probe
3、第二探头                     4、第一电极3. The second probe: 4. The first electrode
5、第二电极                     6、第三电极5. The Second Electrode 6. The third electrode
7、第四电极                      8、显示单元7. The Fourth Electrode 8. Display unit
9、讯号处理模块                 10、存储单元9. Signal processing module 10. Storage unit
11、微处理器                    12、电源模组11. Microprocessor ​ 12. Power module
13、讯号滤波电路                14、讯号放大电路13. Signal filter circuit 14. Signal amplification circuit
15、转换电路                    16、第一电容15. Conversion circuit ​ 16. The first capacitor
17、第二电容17. The second capacitor
本发明的最佳实施方式Best Mode of the Invention
为使本发明实施例的目的、技术方案和优点更加清楚,下面将结合本发明实施例和附图,对本发明实施例中的技术方案进行清楚、完整地描述。需要说明的是,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be described clearly and completely in conjunction with the embodiments of the present invention and the accompanying drawings. It should be noted that the described embodiments are only a part of the embodiments of the present invention, but not all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present invention.
实施例一Example one
请参阅图1至图2,本发明实施例提供了一种非侵入式抗干扰血糖检测仪,包括外露于壳体1之外的由导体构成的第一电极4、第二电极5、第三电极6和第四电极7;以及工作电路;Please refer to FIG. 1 to FIG. 2, an embodiment of the present invention provides a non-invasive anti-interference blood glucose detector, which includes a first electrode 4, a second electrode 5 and a third electrode made of a conductor exposed outside the housing 1 Electrode 6 and fourth electrode 7; and working circuit;
其中,第一电极4、第三电极6及第四电极7设于壳体1的一端组成一个第一探头2,第二电极5单独设于壳体1的另一端组成一个第二探头3;第一电极4与第二电极5连接,用于接触人体的两个不同位置构成回路,以测量数据;第三电极6与第四电极7连接,用于在第一探头2处接触人体构成回路,以测量第一探头2与人体的触点处的干扰数据;Among them, the first electrode 4, the third electrode 6 and the fourth electrode 7 are provided at one end of the casing 1 to form a first probe 2, and the second electrode 5 is separately provided at the other end of the casing 1 to form a second probe 3; The first electrode 4 is connected to the second electrode 5 for contacting two different positions of the human body to form a loop to measure data; the third electrode 6 is connected to the fourth electrode 7 for contacting the human body at the first probe 2 to form a loop To measure the interference data at the contact between the first probe 2 and the human body;
其中,工作电路包括:Among them, the working circuit includes:
讯号处理模块9,用于过滤调整各电极截得的数据;The signal processing module 9 is used to filter and adjust the data intercepted by each electrode;
存储单元10,用于存储使用者抽血检测的数据作首次校正;The storage unit 10 is used to store the data of the user's blood test for the first correction;
微处理器11,用于运算处理讯号处理模块9获得的数据;The microprocessor 11 is used to calculate the data obtained by the signal processing module 9;
电源模组12,用于所有元件的供电;Power module 12, used for power supply of all components;
第一电极4、第二电极5、第三电极6及第四电极7与讯号处理模块9连接,微处理器11与讯号处理模块9连接,存储单元10与微处理器11连接,电源模组12通过电路对各元件实现供电。The first electrode 4, the second electrode 5, the third electrode 6, and the fourth electrode 7 are connected to the signal processing module 9, the microprocessor 11 is connected to the signal processing module 9, the storage unit 10 is connected to the microprocessor 11, and the power module 12 Provide power to each component through the circuit.
与现有技术不同,本发明并非单纯通过两个电极与人体构成回路检测血糖数据,而是采用了四个电极分布在两个探头上,与人体组成了多个回路,以实现干扰数据的扣减运算功能,使检测数据更精准。Unlike the prior art, the present invention does not simply use two electrodes to form a loop with the human body to detect blood glucose data, but uses four electrodes distributed on two probes to form multiple circuits with the human body to achieve interference data deduction The subtraction operation function makes the detection data more accurate.
各电极的工作原理如图3所示。四个电极分别安置在两个探头上,接触人体不同的位置,优选是第一探头2接触人的手掌、第二探头3接触另一只手的拇指。其中,设置于第一探头2上的第一电极4与设置于第二探头3上的第二电极5构成回路,可无侵入地通电检测电子数据。但探头与人体皮肤接触时容易受到触点的接触有效性、湿度、异物等外界因素影响,导致触点附近产生干扰,影响数据的稳定性及精度。因此本发明在第一探头2处设置第三电极6及第四电极7构成回路,在手掌的触点处形成一个扣减回路,专门用于检测并降低触点附近的外界干扰。The working principle of each electrode is shown in Figure 3. The four electrodes are respectively arranged on two probes and contact different positions of the human body. Preferably, the first probe 2 contacts the palm of a person and the second probe 3 contacts the thumb of the other hand. Among them, the first electrode 4 provided on the first probe 2 and the second electrode 5 provided on the second probe 3 form a loop, which can be energized to detect electronic data without intrusion. However, when the probe is in contact with human skin, it is easily affected by external factors such as contact effectiveness, humidity, and foreign objects, causing interference near the contact and affecting the stability and accuracy of the data. Therefore, in the present invention, the third electrode 6 and the fourth electrode 7 are provided at the first probe 2 to form a loop, and a deduction loop is formed at the contact point of the palm, which is specially used to detect and reduce external interference near the contact point.
除了电极的设计以外,本发明还在电路中设置了存储单元10,用于存储使用者用抽血方式测得的真实血糖值以及电极测得的电子数据,以实现数据的校准。因此,本发明并非单纯地测量电子信号。具体的校准方式将在下文的检测血糖方法中详述。In addition to the design of the electrode, the present invention also provides a storage unit 10 in the circuit, which is used to store the real blood glucose value measured by the user by blood drawing and the electronic data measured by the electrode, so as to achieve data calibration. Therefore, the present invention does not simply measure electronic signals. The specific calibration method will be described in detail in the blood glucose detection method below.
需要说明的是,壳体1上可能还装设有各种按钮、开关等,以实现各种控制功能。但这些部件并非本发明的技术重点,与技术方案并无太大关联,在本发明中不再赘述。且说明书附图中省略该结构。It should be noted that various buttons, switches and the like may be installed on the housing 1 to realize various control functions. However, these components are not the technical focus of the present invention and are not much related to the technical solution, and will not be repeated in the present invention. In addition, this structure is omitted in the drawings of the specification.
作为优选,所述讯号处理模块9包括讯号滤波电路13、讯号放大电路14和转换电路15;讯号滤波电路13、讯号放大电路14均连接于由第一电极4与第二电极5、由第三电极6与第四电极7组成的两条回路上;转换电路15与讯号放大电路14连接,微处理器11与转换电路15连接。Preferably, the signal processing module 9 includes a signal filtering circuit 13, a signal amplifying circuit 14 and a conversion circuit 15; the signal filtering circuit 13 and the signal amplifying circuit 14 are connected to the first electrode 4 and the second electrode 5, the third The two circuits composed of the electrode 6 and the fourth electrode 7 are connected; the conversion circuit 15 is connected to the signal amplifying circuit 14, and the microprocessor 11 is connected to the conversion circuit 15.
讯号放大电路14用于接收电极传递的电信号并放大,使微弱的电信号放大后更灵敏。讯号滤波电路13用于整流过滤噪声,得到干净的讯号。转换电路15用于将模拟信号转换成数字信号。The signal amplifying circuit 14 is used to receive and amplify the electrical signals transmitted by the electrodes, so that the weak electrical signals are more sensitive after amplification. The signal filtering circuit 13 is used for rectifying and filtering noise to obtain a clean signal. The conversion circuit 15 is used to convert an analog signal into a digital signal.
作为进一步的优选,所述讯号滤波电路13与讯号放大电路14之间连接有第一电容16及第二电容17,用于将回路形成的讯号电流,经过讯号滤波电路13滤波整流后存入其中。As a further preference, a first capacitor 16 and a second capacitor 17 are connected between the signal filtering circuit 13 and the signal amplifying circuit 14 for storing the signal current formed by the loop after being filtered and rectified by the signal filtering circuit 13 and stored therein .
对于第一探头2上电极的分布及结构,优选采用如下结构。所述第一探头2上分别设有两个中部导体,两中部导体的外围设有一个环形导体,分别作为第一电极4、第三电极6和第四电极7。For the distribution and structure of the electrodes on the first probe 2, the following structure is preferably adopted. The first probe 2 is respectively provided with two middle conductors, and a ring conductor is provided on the outer periphery of the two middle conductors as the first electrode 4, the third electrode 6 and the fourth electrode 7, respectively.
需要说明是,上述三个导体中到底对应作为第一电极4、第三电极6或第四电极7的哪一个,其实并非本发明的技术重点。一般情况下,优选以环形导体作为第三电极6、以两个中部导体分别作为第一电极4及第四电极7。但也可以采用环形导体作为第一电极4、以两个中部导体分别作为第三电极6及第四电极7。第一探头2上设置三个电极的主要目的是消除触点干扰,提高数据采集精度。因此,在不偏离这一设计目的的前提下,第一电极4、第三电极6及第四电极7的编排方式并无过多的限制。It should be noted that which of the three conductors corresponds to the first electrode 4, the third electrode 6 or the fourth electrode 7 is not actually the technical focus of the present invention. In general, it is preferable to use a ring conductor as the third electrode 6 and two middle conductors as the first electrode 4 and the fourth electrode 7, respectively. However, it is also possible to use a ring conductor as the first electrode 4 and two middle conductors as the third electrode 6 and the fourth electrode 7, respectively. The main purpose of setting three electrodes on the first probe 2 is to eliminate contact interference and improve data collection accuracy. Therefore, the arrangement of the first electrode 4, the third electrode 6, and the fourth electrode 7 is not excessively limited without departing from this design goal.
作为优选,还包括显示单元8,用于输出数据处理的结果;显示单元8与微处理器11连接,且外露于壳体1。还包括输入单元,用于输入使用者抽血检测的数据到存储单元10,输入单元与微处理器11连接。Preferably, it further includes a display unit 8 for outputting data processing results; the display unit 8 is connected to the microprocessor 11 and exposed to the housing 1. It also includes an input unit for inputting data of the user's blood test to the storage unit 10, and the input unit is connected to the microprocessor 11.
当然,并不排除本发明本身并不具有显示单元8,通过讯号传输到外部显示设备的方式来显示结果的情况。同理,也可能本发明本身不具有输入单元,通过外部设备无线或有线传输的方式将数据输入到存储单元10也是可行方案。Of course, it does not exclude the case that the present invention does not have the display unit 8 and displays the result by means of signal transmission to an external display device. Similarly, it is also possible that the present invention does not have an input unit, and it is also a feasible solution to input data to the storage unit 10 by wireless or wired transmission by an external device.
本发明提供的一种非侵入式抗干扰血糖检测仪,通过设计多个电极组成多个回路,从而可以通过数据扣减的方式降低检测过程中外界环境的干扰,使检测的数据更精准。且回路的设计具有讯号放大及过滤的功能,进一步提高数据检测的灵敏度及准确性。The present invention provides a non-invasive anti-interference blood glucose detector. By designing multiple electrodes to form multiple circuits, the interference of the external environment during the detection process can be reduced by data deduction, and the detected data is more accurate. And the design of the loop has the function of signal amplification and filtering, which further improves the sensitivity and accuracy of data detection.
本发明的实施方式Embodiments of the invention
实施例二Example 2
本实施例详细说明一种非侵入式抗干扰的检测血糖方法,其实质也是实施例一所述的非侵入式抗干扰血糖检测仪的工作过程。This embodiment details a non-invasive anti-interference blood glucose detection method, and its essence is also the working process of the non-invasive anti-interference blood glucose detector described in the first embodiment.
一种非侵入式抗干扰的检测血糖方法,包括以下步骤:A non-invasive anti-interference method for detecting blood glucose, including the following steps:
S01、使带有电极的第一探头与带有电极的第二探头分别接触人体的不同位置形成回路,往第一探头上的电极打出电流,检测电子数据,计算并存储到存储单元中;S01. Make the first probe with electrodes and the second probe with electrodes respectively contact different positions of the human body to form a loop, draw current to the electrodes on the first probe, detect electronic data, calculate and store in the storage unit;
S02、随后采用医院抽血检测的方式对使用者的血糖值进行检测,并将检测的校正血糖值储存,以步骤S01获得的数据作为校正数据与校正血糖值匹配;S02. Subsequently, the blood glucose value of the user is detected by means of a hospital blood test, and the corrected blood glucose value is stored, and the data obtained in step S01 is used as the corrected data to match the corrected blood glucose value;
S03、需要检测血糖值时,重复步骤S01,将该时刻测得的数据作为即时数据,与步骤S02获得的校正数据及校正血糖值进行比对计算,获得该时刻使用者的即时血糖值。S03. When it is necessary to detect the blood glucose value, repeat step S01, compare the measured data at that time with the corrected data and corrected blood glucose value obtained at step S02, and obtain the user's instant blood glucose value at that time.
 A
本方法主张与抽血测得的真实血糖值作校准匹配计算,因此血糖值的检测并不仅仅是一个单纯的电子数据,而是真正与人体的血糖值匹配的数值。这种方法科学合理,且精准度高,有助于准确判断使用者的血糖情况,不会延误诊治。This method advocates calibration and matching calculation with the real blood glucose value measured by blood drawing. Therefore, the detection of blood glucose value is not just a simple electronic data, but a value that actually matches the blood glucose value of the human body. This method is scientific and reasonable, and has high accuracy, which helps to accurately determine the blood glucose situation of the user and will not delay the diagnosis and treatment.
如上文所述,单纯通过截取电子数据本身对于血糖检测并无实质作用,并无获取真实的血糖值。因此本发明设计出一个校准过程,即需要实施步骤S02,通过到医院抽血检测的方式测出使用者的真实血糖值并输入到血糖检测仪中。在输入该血糖数据前,先通过正常的电极无侵入式检测,截取高精度的电子数据,即可与步骤S02测得的真实血糖值进行匹配,实现校准。该过程实际也是血糖检测仪针对使用者本身的实际身体情况,进行的一次学习过程。通过校准,就能构建一个数据匹配的体系,知道不同的电子数据所对应的血糖值。甚至,还可以建立一个数据库,匹配出对应的血糖值,告知使用者其身体状态。As mentioned above, simply intercepting the electronic data itself has no substantial effect on blood glucose detection, and no real blood glucose value is obtained. Therefore, the present invention devises a calibration process, that is, step S02 needs to be implemented, and the user's real blood glucose value is measured by way of blood sampling in the hospital and input into the blood glucose meter. Before inputting the blood glucose data, non-intrusive detection through normal electrodes is used to intercept high-precision electronic data, which can be matched with the real blood glucose value measured in step S02 to achieve calibration. This process is actually a learning process carried out by the blood glucose detector according to the actual physical condition of the user. Through calibration, a data matching system can be constructed to know the blood glucose value corresponding to different electronic data. Even, a database can be established to match the corresponding blood glucose level to inform the user of his physical condition.
一般建议,每隔一段时间进行一次校准,以便于维持数据的准确性,因为血糖值的变化会随着时间的推移、身体状态的变化有所不同。而对于糖尿病人而言,一般1.5-3个月为一个疗程,因此每隔一段时间进行抽血检测血糖的校准是科学合理的。It is generally recommended to calibrate every once in a while to maintain the accuracy of the data, because changes in blood glucose values will change over time and changes in body state. For diabetics, it is generally 1.5-3 months as a course of treatment, so it is scientific and reasonable to calibrate the blood test blood glucose at intervals.
上述的抽血检测血糖值进行校准的过程,是本发明方法的重要技术突破。通过电子方法检测到的电子数据,即使精度再高,也仅仅是一组电子数据,而非真正的血糖值数据。即使是目前广泛采用的家用采血式血糖仪,也容易受到杂质、血液浓度、血液在仪器中反应是否充分等因素影响,导致血糖值失真。仅当采用到医院抽血进行血糖值检测的方法,获取真实血糖值进行比对校准,仪器测得的血糖值才是准确的。The above-mentioned process of calibrating the blood drawn blood glucose value is an important technical breakthrough of the method of the present invention. The electronic data detected by electronic methods, even if the accuracy is high, is only a set of electronic data, not real blood glucose data. Even the widely used blood-gathering blood glucose meter at home is easily affected by impurities, blood concentration, and whether the blood reacts adequately in the instrument, etc., resulting in distortion of blood glucose value. The blood glucose value measured by the instrument is accurate only when the method of blood sampling in the hospital is used to detect the blood glucose value and the real blood glucose value is obtained for comparison and calibration.
例如,之前测得的电子数据中,电流值是100毫安,并得知该电子数据所对应的血糖值。那之后测得的电子数据中,电流值变成150毫安。微处理器11中写入了计算血糖值的公式,通过该公式就可以计算得出现时对应的血糖值。For example, in the previously measured electronic data, the current value is 100 mA, and the blood glucose value corresponding to the electronic data is known. In the electronic data measured after that, the current value became 150 mA. The formula for calculating the blood glucose value is written in the microprocessor 11, and the corresponding blood glucose value at the time of occurrence can be calculated by the formula.
具体的,所述步骤S01还具体包括:Specifically, the step S01 further specifically includes:
S011、使带有第一电极4、第三电极6及第四电极7的第一探头2与带有第二电极5的第二探头3分别接触人体的不同位置;使第一电极4及第二电极5与人体组成测量回路;使第三电极6及第四电极7与人体在第一探头2的触点处组成扣减回路;S011. Make the first probe 2 with the first electrode 4, the third electrode 6 and the fourth electrode 7 and the second probe 3 with the second electrode 5 contact different positions of the human body; The two electrodes 5 and the human body form a measurement circuit; the third electrode 6 and the fourth electrode 7 and the human body form a deduction circuit at the contact point of the first probe 2;
S012、往第一电极4通电打出电流I 1,并通过电流I 1检测测量回路的电子数据; S012. Energize the first electrode 4 to draw a current I 1 , and detect the electronic data of the measurement circuit through the current I 1 ;
S013、往第一电极4通电打出电流I 1的同时,往第三电极6通电打出电流I 2,并通过总电流I 1+I 2检测扣减回路的电子数据; S013. While the first electrode 4 is energized to draw the current I 1 , the third electrode 6 is energized to draw the current I 2 , and the electronic data of the deduction circuit is detected by the total current I 1 +I 2 ;
S014、微处理器11将测量回路的电子数据与扣减回路的电子数据进行处理计算,获得扣减掉触点干扰后的高精度数据,并储存;S014. The microprocessor 11 processes and calculates the electronic data of the measurement circuit and the electronic data of the deduction circuit to obtain high-precision data after deducting contact interference, and stores the data;
上述步骤中,步骤S011至S014实际是采用血糖检测仪实现电极无侵入式检测的步骤,其具体说明了四个电极通电截取数据的过程,及其降低外界干扰的方法。日常采用血糖检测仪进行血糖检测的过程,就是重复步骤S01的过程。Among the above steps, steps S011 to S014 are actually steps for realizing non-invasive detection of electrodes by using a blood glucose detector, which specifically describes the process of intercepting data by energizing four electrodes and a method of reducing external interference. The process of using a blood glucose tester for blood glucose testing everyday is to repeat the process of step S01.
更具体的,所述步骤S012至S013中,第一电极4通电打出的电流I 1、以及第一电极4和第三电极6同时通电打出的电流I 1+I 2,分别存入第一电容16及第二电容17中,然后分别放电取出第一电容16及第二电容17的电量,分别获得测量回路和扣减回路的电子数据。 More specifically, in the steps S012 to S013, the current I 1 drawn by the first electrode 4 and the current I 1 +I 2 drawn by the first electrode 4 and the third electrode 6 are stored in the first capacitor In the 16 and the second capacitor 17, the electrical energy of the first capacitor 16 and the second capacitor 17 are then discharged to obtain the electronic data of the measurement circuit and the deduction circuit, respectively.
每次进行电极无侵入式检测,均可在某些步骤中重复截取数据,选取有效数据进行计算,以进一步提高检测的数据准确性。优选的,每当执行步骤S011至S014时,所述步骤S012在步骤S013之前以一定时间间隔重复执行多次,取重复次数最多的数据作为测量回路的电子数据。Each time the electrode is not invasively detected, the data can be repeatedly intercepted in certain steps, and valid data can be selected for calculation to further improve the accuracy of the detected data. Preferably, whenever steps S011 to S014 are executed, the step S012 is repeatedly executed at a certain time interval before step S013, and the data with the most repetitions is taken as the electronic data of the measurement loop.
例如,第一电极4每隔0.1秒打出一个微小电流I 1至人体,第三电极6每隔0.5秒打出微小电流I 2至人体。那么在0.5秒前,第一电极4就多次进行了电流通电检测(即重复执行了多次步骤S02),可抓取其中重复次数最多的数据作为测量回路的电子数据。在第0.5秒的时候,第一电极4、第三电极6同时打出电流,则计算时,使用的电流值为I 1+I 2之和。 For example, the first electrode 4 delivers a minute current I 1 to the human body every 0.1 seconds, and the third electrode 6 delivers a tiny current I 2 to the human body every 0.5 seconds. Then, 0.5 seconds ago, the first electrode 4 performed current energization detection multiple times (that is, the step S02 was repeatedly performed multiple times), and the data with the most repetitions could be captured as the electronic data of the measurement loop. At the 0.5th second, the first electrode 4 and the third electrode 6 draw current at the same time, and the current value used in the calculation is the sum of I 1 +I 2 .
经实验发现,第一探头2与人体触点接触后,并非马上就能通电获取稳定的电子数据,而是刺激使用者一定时间后,数据才趋向稳定。因此优选的,每当执行步骤S011至S014时,在步骤S011刺激使用者0.8-1.1秒后,再执行步骤S012至S014,有利于获得稳定的电子数据。It has been found through experiments that after the first probe 2 comes into contact with the human body contacts, it is not immediately possible to energize to obtain stable electronic data, but to stimulate the user for a certain time before the data tends to be stable. Therefore, it is preferable that whenever steps S011 to S014 are executed, after step S011 stimulates the user for 0.8-1.1 seconds, steps S012 to S014 are executed again, which is beneficial to obtain stable electronic data.
更进一步的,除了等待数据稳定,还可在电极与人体的触点接触后,通过多次重复截取数据的方式来获取有效数据。优选的是,每当执行步骤S011至S014时,重复多次执行步骤S012至S014,取重复次数最多的高精度数据。Furthermore, in addition to waiting for the data to stabilize, it is also possible to obtain valid data by repeatedly intercepting the data after the electrode contacts the contact of the human body. Preferably, each time steps S011 to S014 are executed, steps S012 to S014 are repeatedly executed multiple times to take the high-precision data with the most repetitions.
例如,在电极与人体的触点接触后,在0.8-1.1秒有稳定数据出现。那么就在0.8-1.1秒区间进行数据截取,并多次重启在这个时间区间截取多个数据,抓取其中的有效数据。For example, after the electrode comes into contact with the contact of the human body, stable data appears in 0.8-1.1 seconds. Then, intercept data in the interval of 0.8-1.1 seconds, and restart multiple times to intercept multiple data in this interval to capture the valid data.
关于测定计算方法的进一步改进,可以在所有步骤前,具有一个预处理步骤S00,其具有如下步骤,For further improvement of the determination calculation method, before all the steps, there may be a pre-processing step S00, which has the following steps,
S001、按血糖值高低的严重程度对不同高低的血糖值进行分类;S001. Classify the blood glucose levels of different levels according to the severity of the blood glucose level;
S002、在不同分类的标准血糖值的基础上,按照正负容差计算出各分类的区间值,建立起不同分类的数值区间的数据库;S002. Based on the standard blood glucose values of different categories, calculate the interval values of each category according to the positive and negative tolerances, and establish a database of numerical intervals of different categories;
步骤S03获得的即时血糖值与步骤S002中建立的数据库进行比对,获得使用者的状态。The instant blood glucose value obtained in step S03 is compared with the database established in step S002 to obtain the user's status.
例如,按照血糖值高低的严重程度,大致可分为:For example, according to the severity of blood sugar level, it can be roughly divided into:
状态status 血糖值Blood sugar level
正常normal 5.45.4
危险群Risk group 6.56.5
糖尿病二型Type 2 Diabetes 10.810.8
糖尿病一型Type 1 diabetes 16.216.2
可选定容差值为±10%,确定出区间值:The tolerance value can be selected to be ±10%, and the interval value is determined:
状态status 血糖值区间Blood glucose level
正常normal 4.9-5.94.9-5.9
危险群Risk group 5.9-7.25.9-7.2
糖尿病二型Type 2 Diabetes 9.7-11.99.7-11.9
糖尿病一型Type 1 diabetes 14.6-17.814.6-17.8
步骤S03测得的即时血糖值可以直接与血糖值区间进行比对,马上知道使用者处于哪个状态,方便医师追踪治疗,调整用药。由于电子讯号很微弱,每个人对电子反应也会有差异,借由校正先锁定使用者落在哪一类型,再辅以一定百分比的机率误差来缩小范围以逼近准确度。The instant blood glucose value measured in step S03 can be directly compared with the blood glucose value interval, and immediately know which state the user is in, which is convenient for the doctor to track the treatment and adjust the medication. Because the electronic signal is very weak, everyone's response to the electronic will also be different. By correcting the type of user first, and then supplementing with a certain percentage of probability errors to narrow the range to approximate accuracy.
上述的数值区间分布仅仅是一种应用举例,即使数值区间的分布有所不同,或者再进一步细分,都属于本发明的构思。The above numerical interval distribution is only an application example, even if the numerical interval distribution is different, or further subdivided, it belongs to the concept of the present invention.
本发明提供的一种非侵入式抗干扰的检测血糖方法,采用更先进的多电极测量方法,避免干扰,测得更精准的数据。且具有科学的数据校准方法,从而匹配出真实准确的血糖值。The invention provides a non-invasive anti-interference method for detecting blood glucose, which adopts a more advanced multi-electrode measurement method to avoid interference and obtain more accurate data. And has a scientific data calibration method, so as to match the true and accurate blood glucose values.
以上所述实施例仅表达了本发明的几种实施方式,其描述较为具体和详细,但并不能因此而理解为对本发明专利范围的限制。应当指出的是,对于本领域的普通技术人员来说,在不脱离本发明构思的前提下,还可以做出若干变形和改进,这些都属于本发明的保护范围。因此,本发明专利的保护范围应以所附权利要求为准。The above examples only express several implementations of the present invention, and their descriptions are more specific and detailed, but they should not be construed as limiting the patent scope of the present invention. It should be noted that, for a person of ordinary skill in the art, without departing from the concept of the present invention, a number of modifications and improvements can also be made, which all fall within the protection scope of the present invention. Therefore, the protection scope of the invention patent shall be subject to the appended claims.

Claims (12)

  1. 一种非侵入式抗干扰血糖检测仪,其特征在于:包括外露于壳体之外的由导体构成的第一电极、第二电极、第三电极和第四电极;以及工作电路;A non-invasive anti-interference blood glucose detector, which is characterized by comprising a first electrode, a second electrode, a third electrode and a fourth electrode made of a conductor exposed outside the casing; and a working circuit;
    其中,第一电极、第三电极及第四电极设于壳体的一端组成一个第一探头,第二电极单独设于壳体的另一端组成一个第二探头;第一电极与第二电极连接,用于接触人体的两个不同位置构成回路,以测量数据;第三电极与第四电极连接,用于在第一探头处接触人体构成回路,以测量第一探头与人体的触点处的干扰数据;Among them, the first electrode, the third electrode and the fourth electrode are provided at one end of the casing to form a first probe, and the second electrode is separately provided at the other end of the casing to form a second probe; the first electrode is connected to the second electrode , Used to form a loop at two different locations that contact the human body to measure data; the third electrode is connected to the fourth electrode to form a loop at the first probe to contact the human body to measure the contact between the first probe and the human body Interfere with data;
    其中,工作电路包括:Among them, the working circuit includes:
    讯号处理模块,用于过滤调整各电极截得的数据;The signal processing module is used to filter and adjust the data intercepted by each electrode;
    存储单元,用于存储使用者抽血检测的数据作首次校正;The storage unit is used to store the data of the user's blood test for the first correction;
    微处理器,用于运算处理讯号处理模块获得的数据;Microprocessor, used to calculate the data obtained by the signal processing module;
    电源模组,用于所有元件的供电;Power module for power supply of all components;
    第一电极、第二电极、第三电极及第四电极与讯号处理模块连接,微处理器与讯号处理模块连接,存储单元与微处理器连接,电源模组通过电路对各元件实现供电。The first electrode, the second electrode, the third electrode, and the fourth electrode are connected to the signal processing module, the microprocessor is connected to the signal processing module, the storage unit is connected to the microprocessor, and the power module supplies power to each component through the circuit.
  2. 根据权利要求1所述的非侵入式抗干扰血糖检测仪,其特征在于:所述讯号处理模块包括讯号滤波电路、讯号放大电路和转换电路;讯号滤波电路、讯号放大电路均连接于由第一电极与第二电极、由第三电极与第四电极组成的两条回路上;转换电路与讯号放大电路连接,微处理器与转换电路连接。The non-invasive anti-interference blood glucose detector according to claim 1, wherein the signal processing module includes a signal filtering circuit, a signal amplifying circuit and a conversion circuit; the signal filtering circuit and the signal amplifying circuit are connected to the first The electrode and the second electrode, the two loops composed of the third electrode and the fourth electrode; the conversion circuit is connected to the signal amplification circuit, and the microprocessor is connected to the conversion circuit.
  3. 根据权利要求2所述的非侵入式抗干扰血糖检测仪,其特征在于:所述讯号滤波电路与讯号放大电路之间连接有第一电容及第二电容,用于将回路形成的讯号电流,经过讯号滤波电路滤波整流后存入其中。The non-invasive anti-interference blood glucose detector according to claim 2, characterized in that: a first capacitor and a second capacitor are connected between the signal filter circuit and the signal amplification circuit for signal current formed by the loop, Stored in the signal filter circuit after filtering and rectification.
  4. 根据权利要求1所述的非侵入式抗干扰血糖检测仪,其特征在于:所述第一探头上分别设有两个中部导体,两中部导体的外围设有一个环形导体,分别作为第一电极、第三电极和第四电极。The non-invasive anti-interference blood glucose detector according to claim 1, wherein the first probe is provided with two middle conductors, and the outer circumference of the two middle conductors is provided with a ring conductor, which serves as the first electrode , The third electrode and the fourth electrode.
  5. 根据权利要求1所述的非侵入式抗干扰血糖检测仪,其特征在于:还包括显示单元,用于输出数据处理的结果;显示单元与微处理器连接,且外露于壳体。The non-invasive anti-interference blood glucose detector according to claim 1, further comprising a display unit for outputting data processing results; the display unit is connected to the microprocessor and is exposed to the casing.
  6. 根据权利要求1所述的非侵入式抗干扰血糖检测仪,其特征在于:还包括输入单元,用于输入使用者抽血检测的数据到存储单元,输入单元与微处理器连接。The non-invasive anti-interference blood glucose detector according to claim 1, characterized in that it further comprises an input unit for inputting data of the user's blood test to the storage unit, and the input unit is connected to the microprocessor.
  7. 一种非侵入式抗干扰的检测血糖方法,其特征在于:包括以下步骤:A non-invasive anti-interference method for detecting blood glucose, characterized in that it includes the following steps:
    S01、使带有电极的第一探头与带有电极的第二探头分别接触人体的不同位置形成回路,往第一探头上的电极打出电流,检测电子数据,计算并存储到存储单元中;S01. Make the first probe with electrodes and the second probe with electrodes respectively contact different positions of the human body to form a loop, draw current to the electrodes on the first probe, detect electronic data, calculate and store in the storage unit;
    S02、随后采用医院抽血检测的方式对使用者的血糖值进行检测,并将检测的校正血糖值储存,以步骤S01获得的数据作为校正数据与校正血糖值匹配;S02. Subsequently, the blood glucose value of the user is detected by means of a hospital blood test, and the corrected blood glucose value is stored, and the data obtained in step S01 is used as the corrected data to match the corrected blood glucose value;
    S03、需要检测血糖值时,重复步骤S01,将该时刻测得的数据作为即时数据,与步骤S02获得的校正数据及校正血糖值进行比对计算,获得该时刻使用者的即时血糖值。S03. When it is necessary to detect the blood glucose value, repeat step S01, compare the measured data at that time with the corrected data and corrected blood glucose value obtained at step S02, and obtain the user's instant blood glucose value at that time.
  8. 根据权利要求7所述的非侵入式抗干扰的检测血糖方法,其特征在于,所述步骤S01具体包括:The non-invasive anti-interference blood glucose detection method according to claim 7, wherein the step S01 specifically includes:
    S011、使带有第一电极、第三电极及第四电极的第一探头与带有第二电极的第二探头分别接触人体的不同位置;使第一电极及第二电极与人体组成测量回路;使第三电极及第四电极与人体在第一探头的触点处组成扣减回路;S011. Make the first probe with the first electrode, the third electrode and the fourth electrode and the second probe with the second electrode contact different positions of the human body; make the first electrode, the second electrode and the human body form a measurement circuit ; Make the third electrode and the fourth electrode and the human body form a deduction loop at the contact point of the first probe;
    S012、往第一电极通电打出电流I 1,并通过电流I 1检测测量回路的电子数据; S012. Energize the first electrode to draw a current I 1 , and detect the electronic data of the measurement loop through the current I 1 ;
    S013、往第一电极通电打出电流I 1的同时,往第三电极通电打出电流I 2,并通过总电流I 1+I 2检测扣减回路的电子数据; S013. While the first electrode is energized to draw a current I 1 , the third electrode is energized to draw a current I 2 , and the electronic data of the deduction circuit is detected by the total current I 1 +I 2 ;
    S014、微处理器将测量回路的电子数据与扣减回路的电子数据进行处理计算,获得扣减掉触点干扰后的高精度数据,并储存。S014. The microprocessor processes and calculates the electronic data of the measurement circuit and the electronic data of the deduction circuit to obtain high-precision data after deducting contact interference, and stores the data.
  9. 根据权利要求8所述的非侵入式抗干扰的检测血糖方法,其特征在于:所述步骤S012至S013中,第一电极通电打出的电流I 1、以及第一电极和第三电极同时通电打出的电流I 1+I 2,分别存入第一电容及第二电容中,然后分别放电取出第一电容及第二电容的电量,分别获得测量回路和扣减回路的电子数据。 The non-invasive anti-interference blood glucose detection method according to claim 8, characterized in that: in steps S012 to S013, the current I 1 drawn by the first electrode is energized, and the first electrode and the third electrode are simultaneously energized to output The current I 1 +I 2 is stored in the first capacitor and the second capacitor respectively, and then the electrical energy of the first capacitor and the second capacitor is discharged to obtain the electronic data of the measurement circuit and the deduction circuit respectively.
  10. 根据权利要求8所述的非侵入式抗干扰的检测血糖方法,其特征在于:每当执行步骤S011至S014时,所述步骤S012在步骤S013之前以一定时间间隔重复执行多次,取重复次数最多的数据作为测量回路的电子数据。The non-invasive anti-interference blood glucose detection method according to claim 8, characterized in that whenever step S011 to step S014 are executed, step S012 is repeatedly executed at a certain time interval before step S013, and the number of repetitions is taken The most data is the electronic data of the measuring circuit.
  11. 根据权利要求8或10所述的非侵入式抗干扰的检测血糖方法,其特征在于:每当执行步骤S011至S014时,在步骤S01刺激使用者0.8-1.1秒后,再重复多次执行步骤S012至S014,以获得稳定、高精度的电子数据。The non-invasive anti-interference blood glucose detection method according to claim 8 or 10, characterized in that each time steps S011 to S014 are executed, after step S01 stimulates the user for 0.8-1.1 seconds, the steps are repeated multiple times S012 to S014 to obtain stable and high-precision electronic data.
  12. 根据权利要求7所述的非侵入式抗干扰的检测血糖方法,其特征在于:The non-invasive anti-interference blood glucose detection method according to claim 7, characterized in that:
    在所有步骤前,具有一个预处理步骤S00,其具有如下步骤,Before all the steps, there is a pre-processing step S00, which has the following steps,
    S001、按血糖值高低的严重程度对不同高低的血糖值进行分类;S001. Classify the blood glucose levels of different levels according to the severity of the blood glucose level;
    S002、在不同分类的标准血糖值的基础上,按照正负容差计算出各分类的区间值,建立起不同分类的数值区间的数据库;S002. Based on the standard blood glucose values of different categories, calculate the interval values of each category according to the positive and negative tolerances, and establish a database of numerical intervals of different categories;
    步骤S03获得的即时血糖值与步骤S002中建立的数据库进行比对,获得使用者的状态。The instant blood glucose value obtained in step S03 is compared with the database established in step S002 to obtain the user's status.
PCT/CN2018/124207 2018-12-18 2018-12-27 Non-invasive anti-interference blood glucose measuring instrument and blood glucose measuring method therefor WO2020124658A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201811553156.7 2018-12-18
CN201811553156.7A CN111329490A (en) 2018-12-18 2018-12-18 Non-invasive anti-interference blood glucose detector and method for detecting blood glucose by using same

Publications (1)

Publication Number Publication Date
WO2020124658A1 true WO2020124658A1 (en) 2020-06-25

Family

ID=71102437

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/124207 WO2020124658A1 (en) 2018-12-18 2018-12-27 Non-invasive anti-interference blood glucose measuring instrument and blood glucose measuring method therefor

Country Status (2)

Country Link
CN (1) CN111329490A (en)
WO (1) WO2020124658A1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001276021A (en) * 2000-04-03 2001-10-09 Nishitomo:Kk Blood sugar value meter
CN102727215A (en) * 2012-06-08 2012-10-17 林建中 Blood collection-free blood sugar measurement instrument and testing method
CN205019055U (en) * 2015-07-22 2016-02-10 通普生物科技(北京)有限公司 Multi -functional health detector
CN106667498A (en) * 2017-03-03 2017-05-17 蔡曜聪 Physiological detection device
CN207168497U (en) * 2017-01-10 2018-04-03 广州康万家医药有限公司 A kind of non-invasive blood sugar instrument

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001276021A (en) * 2000-04-03 2001-10-09 Nishitomo:Kk Blood sugar value meter
CN102727215A (en) * 2012-06-08 2012-10-17 林建中 Blood collection-free blood sugar measurement instrument and testing method
CN205019055U (en) * 2015-07-22 2016-02-10 通普生物科技(北京)有限公司 Multi -functional health detector
CN207168497U (en) * 2017-01-10 2018-04-03 广州康万家医药有限公司 A kind of non-invasive blood sugar instrument
CN106667498A (en) * 2017-03-03 2017-05-17 蔡曜聪 Physiological detection device

Also Published As

Publication number Publication date
CN111329490A (en) 2020-06-26

Similar Documents

Publication Publication Date Title
US20070149876A1 (en) Methods and devices for non-invasively measuring quantitative information of substances in living organisms
US7719427B2 (en) Wireless pH measurement system
US9294732B2 (en) Systems and methods for sleep monitoring
CN109793516B (en) Skin electrical impedance flexible detection device and skin electrical impedance detection method
WO2011027438A1 (en) Pulse measuring device
CN107320089A (en) Self-alignment human blood-pressure measuring method
TW201306798A (en) Blood pressure measurement system with automatic inspection and self-calibration functions
US20140051942A1 (en) Systems And Methods For Sleep Monitoring
WO2020124658A1 (en) Non-invasive anti-interference blood glucose measuring instrument and blood glucose measuring method therefor
US20160051170A1 (en) Bloodless Glucose Measuring Device and Method of Use Thereof
TW202135726A (en) Implantable capsule and gastroesophageal reflux disease determining system thereof
CN209437250U (en) A kind of anti-interference blood-sugar detecting instrument of non-intrusion type
TWI742330B (en) A calculation method for anti-interference non-invasive blood glucose detection
TWM590030U (en) Anti-interference non-invasive blood glucose detection
WO2023045216A1 (en) Automatic measurement calibration method and device for ventilator, and storage medium
KR101963790B1 (en) glucose measuring device for automatically percepting a code signal of senser strip
CN206534637U (en) Induction type pressure electrocardio measuring device
CN107928682B (en) Information acquisition sensor and physiological parameter acquisition device
CN106491128A (en) A kind of sensor of measurement surface electromyographic signal and measuring method
Buckley et al. A Miniaturized ISFET-Based Blood pH Sensing Device for Home Care Use
CN215305821U (en) Quick measuring device of many vital signs
CN210961943U (en) Circuit control system of electronic sphygmomanometer
TWI729387B (en) Wearable device for physiological data detection
TWM553179U (en) Physiological detecting device
JPH01300963A (en) Anesthetic intensity monitor

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18943770

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18943770

Country of ref document: EP

Kind code of ref document: A1