WO2020116225A1 - Living body improvement method, and electrolysis-type hydrogen generator for implementing said method - Google Patents

Abstract

[Problem] To provide a living body improvement method with which vital function and/or cognitive function is improved by regularly inhaling, through the mouth or nose, air containing a high concentration of hydrogen using a portable electrolysis-type hydrogen generator. [Solution] In this living body improvement method, for example, air containing a high concentration of hydrogen is inhaled for a prescribed amount of time at least 5 times per day at intervals of approximately at least 15 minutes, and this inhalation is continued for approximately 4 weeks or more. An electrolysis-type hydrogen generator used in this method is portable, and comprises: a positive-negative electrode pair; a transparent or semi-transparent electrolytic cell into which the electrode pair is inserted and which is capable of storing water; a mixing unit that establishes a fluid connection between the electrolytic cell and a nozzle which enables oral or nasal inhalation while being gripped with one hand, and that has a fluid passage which takes in environment air; and an operation means which can be operated while the electrolysis-type hydrogen generator is gripped with one hand. A control board controls, through a single operation of the operation means, the supply and cutoff of power from a battery to the positive-negative electrodes.

Description

Biological improvement method and electrolysis-type hydrogen generator for implementing this method

The present invention relates to a method for improving a living body, which improves a living function and/or a cognitive function by regularly orally or nasally inhaling high-concentration hydrogen-containing air using a portable electrolysis-type hydrogen generator, and It relates to an electrolytic hydrogen generator suitable for carrying out the method.

In recent years, the effectiveness of hydrogen has been attracting attention in human clinical experiments, and various studies in medical applications are being actively conducted. Methods for administering hydrogen to the human body include intravenous administration, oral administration of an aqueous solution, gas inhalation (nasal inhalation), etc., and there are a wide variety of methods for taking hydrogen into the body.

However, in the past, medical clinical trials were often found in the administration of hydrogen-containing aqueous solutions, eye drops, etc., and no clear clinical trial regarding gas inhalation was provided. On the other hand, the general awareness and market of gas inhalation such as pseudo electronic cigarettes and cigarettes that do not emit sidestream smoke due to the recent smoking cessation boom are expanding, and along with this, the inhalation of hydrogen, which is thought to lead to health promotion, is also increasing. Attention has been paid.

On the other hand, it has been pointed out that the effect of hydrogen inhalation on the body and mind depends on speculation and emotions.Therefore, there is a need for clinical trials to determine what biological reactions actually occur by inhaling hydrogen. Has been.

Under such circumstances, the inventor has conducted various clinical trials on biological reactions caused by inhalation of hydrogen, and obtained empirical results showing that brain stress reduction and remarkable effects on physical functions were observed (see Patent Document 3). From this fact, it was considered that parasympathetic nerve becomes dominant when hydrogen is sucked, stress and fatigue are reduced, and left and right cognitive functions are improved. At the same time, based on this result, the applicant provided a device that allows a general user to suck hydrogen in a daily routine.

However, the above results could only confirm the reduction of cerebral stress and the improvement of physical function within a predetermined time after the inhalation of hydrogen, and the cognitive function/lifestyle was constantly maintained in patients with dementia and middle-aged and elderly people. The effect of continuous inhalation was not observed in those with impaired function.

On the other hand, in Japan, there is an urgent need for so-called disease-free measures and dementia measures for the coming aging society, and it is estimated that the prevalence rate of 20% will reach 20% among the elderly who actually present cognitive impairment. .. For cognitive impairment, early diagnosis and early treatment are required, but preventive care to prevent cognitive decline is still under investigation. In particular, those with suspected mild cognitive impairment (MCI) are in a state before being recognized as dementia, and there are a large number of potential people without awareness, while maintaining/recovering cognitive function by preventive care. If it is possible to improve the cognitive function of these persons and to improve their physical and mental health, it is considered to be one of the dementia care and the health support for the elderly and has great social significance.

In such a situation, the inventors obtained the knowledge of the reduction of cerebral stress and the improvement of physical function by hydrogen suction as described above, and further applied it to the improvement of cognitive function and the preventive care of a person suspected of having mild cognitive impairment (MCI). We have been researching and developing the method of absorbing hydrogen and the equipment applicable to it.

JP 2004-41949 A Japanese Patent Application No. 2014-019640 International publication WO2018/151107

The present invention was created in view of the above circumstances, and allows middle-aged and elderly people including those suspected of having mild cognitive impairment (MCI) to normally orally or nasally inhale a high-concentration hydrogen-containing air. The present invention aims to provide a living body improving method for improving a living function and/or a cognitive function, and at the same time, to provide an appropriate hydrogen generator (hydrogen suction device) for carrying out the method.

In order to solve the above-mentioned problems, a method for improving a living body and/or a cognitive function of the present invention, and a portable electrolysis hydrogen generator used for improving a living function and/or a cognitive function are described below. provide.

First, as a first aspect of the present invention, a living body that improves daily life and/or cognitive function by regularly orally or nasally inhaling high-concentration hydrogen-containing air using a portable electrolysis hydrogen generator. Provide an improvement method.

As in the case of the method for improving living body of the first aspect of the present invention, if high-concentration hydrogen-containing air is routinely ingested by oral or nasal inhalation under natural respiration, the living function and cognitive function can be improved as described later. Up to now, short-term biological reactions immediately after oral or nasal inhalation of hydrogen have been verified, but this time, as will be described later, regular inhalation of hydrogen, such as inhaling several times every day for several minutes, will lead to a consistent daily life function and life function. It is known that cognitive function is improved and maintained. In addition, in order to achieve this, it also provides the point that it is desirable to suck high concentration hydrogen with an electrolysis type hydrogen generator as a best mode that can suck a predetermined amount of hydrogen or more on a daily basis. It can be said that the present invention (the second invention described later) is a great advantage.

Further, it is preferable that the high-concentration hydrogen-containing air is aspirated by the present bioimprovement method at intervals of about 15 minutes or more, 5 times or more every day for a predetermined time, and continued for about 4 weeks or more.

For example, by inhaling hydrogen 5 times or more every day for about 5 minutes each time, and continuing this for 4 weeks or more, it is possible to surely improve the living function and/or cognitive function. The suction time can be continuous regardless of the suction time, but it is preferable to open at least about 15 minutes and suction 5 times daily such as "wake up, after breakfast, after lunch, after dinner, before bedtime". It is also an advantage of the present invention that a reliable effect is expected by continuously sucking for about 4 weeks, and that the effect is maintained even after the hydrogen suction is stopped.

The second aspect of the present invention is a portable electrolysis-type hydrogen generator used for improving the daily function and/or the cognitive function by inhaling orally or nasally inhaling high-concentration hydrogen-containing air,
A main body cover member including a battery, a control substrate that controls power supply from the battery, and a pair of positive and negative electrodes that energize or shield the anode and the cathode by the control substrate,
A transparent or semi-transparent electrolytic cell which is attached to the main body cover member, in which the pair of positive and negative electrodes is inserted, and which can store water;
A mixing section which has a flow path for taking in ambient air while fluidly connecting a nozzle section capable of oral or nasal suction while gripping with one hand and the electrolytic cell,
An operating unit that can be operated while holding the electrolytic hydrogen generator with the one hand,
Equipped with
The control board provides an electrolysis hydrogen generator, which controls the supply and stop of electric power from the battery to the positive and negative electrodes by operating one operating means.

The electrolysis-type hydrogen generator of the second aspect of the present invention is a portable hydrogen generator for inhaling orally or nasally inhaling high-concentration hydrogen-containing air as a dedicated product used for improving a living function and/or a cognitive function. is there. As described above in the first aspect of the present invention, when high-concentration hydrogen-containing air is routinely ingested into the body by oral or nasal inhalation under natural respiration, improvement in life function and/or cognitive function is observed, and this improvement is appropriate. As a dedicated device that can be achieved in the above, each characteristic configuration is adopted in this electrolysis-type hydrogen generator. First, the electrolysis-type hydrogen generator is portable and can be operated while grasping with one hand during hydrogen suction, and the electrolysis-type hydrogen generation system is adopted. In order to improve life function and/or cognitive function, it is necessary to inhale high-concentration hydrogen-containing air on a regular basis, for example, at intervals of about 15 minutes or more, at least 5 times a day for a predetermined time, and for about 4 weeks or more. However, it is essential to have portability because it can be easily used at any place such as home. In addition, it is necessary to secure the amount of hydrogen generated while being small enough to be portable, and an electrolysis type is adopted in which it is easy to control the amount of hydrogen generated even in a small space according to the electromotive force. In addition, it is difficult to obtain a proper effect by requesting a complicated operation that is regularly used by a user whose cognitive function is deteriorated. Therefore, at least the operation related to hydrogen generation/stopping can be performed with one hand when grasping hydrogen. It adopts a configuration that can be easily operated. Furthermore, in the case of electrolysis type hydrogen generation, bubbles of hydrogen and oxygen are generated in the electrolytic cell, and if the electrolytic cell is made transparent or semi-transparent, the cognitive function deteriorates and the ability to continue one work decreases. Even a user who is doing so can understand the generation state of bubbles and easily recognize that good gas is being sucked. It is also advantageous in this respect (it is easy for a caregiver to understand).

In addition, this electrolysis-type hydrogen generator is
The operating means is a button type that can be pressed, and when it is continuously pressed a plurality of times, it sends an ON/OFF signal of a main power source to the control board, and when the main power source is in an ON state, it is pressed and the pressed state is maintained. It is preferable that the control board supplies electric power from the battery to the positive and negative electrodes and controls so as to stop the electric power supply from the battery to the positive and negative electrodes when the pressed state is released.

In order to use the electrolysis-type hydrogen generator with a user whose cognitive function is deteriorated, it is preferable to turn on/off the main power source and to turn on/off the electricity related to hydrogen generation with a so-called push button. Hydrogen is generated only when the push button is held down.

Further, the control board of the electrolysis-type hydrogen generating tool presses the operation button in the main power-on state, and stops the power supply from the battery to the positive and negative electrodes when a preset time elapses in the pressed state. It is preferable to control as follows.

Even with the electrolysis type hydrogen generator of the type that sucks hydrogen while pressing the push button as described above, even if the push button is pressed after a specified time (5 minutes, etc.), the electricity is automatically cut off to generate hydrogen. To stop. In order to improve the living function and/or cognitive function, it is preferable to continuously inhale the hydrogen-containing air for a predetermined number of times every day, but an elderly person or a user whose cognitive function is deteriorated grasps the inhalation time each time. It may be difficult to manage the time yourself, and even if the operation button is held down, if the recommended suction time (5 minutes, etc.) elapses, the energization of the positive and negative electrodes will be cut off, and the user will manage it. It is possible to manage the suction time naturally without it.

Furthermore, the electrolysis-type hydrogen generating device includes an LED for irradiating the electrolytic cell,
It is preferable that the control board energize the LED when power is supplied from the battery to the positive and negative electrodes.

According to this electrolysis type hydrogen generator, the electrolytic cell is irradiated while the positive and negative electrodes are energized and hydrogen etc. is being generated, and it is possible to easily recognize the hydrogen generation state and generate bubbles inside. Since it is clearly visible, even if the air contains hydrogen, which is tasteless and odorless, it is possible to admit hydrogen suction. Further, it is advantageous in that it is easy to manage even a caregiver of a user whose cognitive function is deteriorated because even a person who is far from the suction user can understand whether or not the user is in the hydrogen suction state.

According to the present invention, middle-aged and elderly people including those suspected of having mild cognitive impairment (MCI) are orally or nasally inhaled high-concentration hydrogen-containing air to improve their living function and/or cognitive function. (EN) A method for improving a living body is provided, and at the same time, an appropriate hydrogen generator (hydrogen suction device) for carrying out the method is provided.

The electricity of the second aspect of the present invention, which is suitable for carrying out the method for improving the living body of the first aspect of the present invention, which comprises regularly orally or nasally inhaling high-concentration hydrogen-containing air to improve living functions and/or cognitive functions. FIG. 4 is a cross-sectional view taken along the line AA of FIG. 3 showing an example of the decomposition type hydrogen generating device. The figure which looked at each direction of the electrolysis-type hydrogen generator shown in FIG. 1 is shown, (a) is a left side view, (b) is a front view, (c) is a right side view, (d) is a bottom view. The figure and (e) have shown the top view. It is an assembly exploded view which illustrates each member of the electrolysis type hydrogen generating tool shown in FIG. 2 is a list of verification test results using the electrolytic hydrogen generator shown in FIG. 1.

First, an example of a living body improving method (hereinafter, also simply referred to as “the living body improving method”) for improving the living function and/or cognitive function of the present invention and its verification result will be described below.

In the verification test using this method for improving living organisms, a hydrogen generator for health improvement (generally, an electrolysis-type hydrogen gas suction tool 100 (“Kencos 2” manufactured by Aquabank Co., Ltd., “Kencos 2” (see FIGS. 1 to 3)) described later) is generated. Inhaled the generated hydrogen orally. Specifically, hydrogen generated by the electrolysis-type hydrogen gas suction device 100 is naturally breathed for about 4 weeks, 5 times a day (15 minutes or more if continuously inhaled. Desirably after waking up and breakfast Suck for several minutes (preferably for about 5 minutes) once after, after lunch, after dinner, and before going to bed. The amount of hydrogen generated per unit time of the electrolysis hydrogen gas suction tool 100 used in this verification test is 8 cc of hydrogen generated per minute by the electrolysis method (at the same time, 4 cc of oxygen is also generated). 12 cc of mixed gas of oxygen and hydrogen is generated. This mixed gas is sucked under natural respiration. Note that normally, in natural respiration, the maximum amount of mixed gas generated in an exhaled breath is 0.24% (hydrogen 0.18% Oxygen 0.06%) is included.

The gases generated from the electrolysis-type hydrogen gas suction tool 100 are hydrogen and oxygen, and both the hydrogen concentration and the oxygen concentration in the mixed gas will be higher than in the atmosphere, but each concentration increase is as described above. 0.18% and oxygen 0.06%, while each concentration in the atmosphere is 0.5×10 ⁻⁴ % (=0.5 ppm) hydrogen and about 21% oxygen. Therefore, it can be considered that the increase of the oxygen concentration in the mixed gas is very small, and contributes to the increase of the hydrogen concentration.

The test subject was an elderly person aged 60 years or older who was selected in cooperation with the Health Support Division of Nishinoomote City, Kagoshima Prefecture. Before the group was divided into two groups and started at the venue attached to the city hall (hereinafter also referred to as "test venue") .) in each group (see questionnaires (1) to (3) and tests (1) to (7) described later)), and each group brought back an electrolysis hydrogen gas suction tool Inhalation was performed for 30 days, and the other group decided not to perform hydrogen aspiration. After 30 days, both groups will conduct the same tests as at the start. After that, the group that had been sucking hydrogen stopped the suction, and conversely, the group that had not sucked hydrogen started sucking hydrogen. After a further 30 days, each group carried out each test again at the start, and the difference in the results was evaluated.

The questionnaires and tests conducted on the subjects before hydrogen absorption are as follows.
Although various tests were conducted, we will mention the ones that were clearly significant this time.
≪ Questionnaire (in the test hall)≫
(1) MOS 8-Item Short-Form Health Survery (SF-8)
It evaluates the QOL of objective and subjective contents regarding overall health.
(2) Old Institute-type activity ability index This is to evaluate the IADL of elderly people.
(3) JST version activity capability index

≪Each test (in the test hall)≫
(1) MMSE Dementia Confirmation Test This is a test consisting of 11 out of 30 points, including orientation, memory, calculation, verbal ability, and figure ability. A score of 24 or more is normal, and a score of less than 10 is highly inferior, and a score of less than 20 is moderately inferior.

(2) Self-rating Depression Scale (SDS)
It consists of 20 questions, all of which are rated on a 4-point scale (always, often, and rarely). Specifically, the depressive state factors are "depression, depression, sadness", "daytime fluctuation", "crying", "sleep", "appetite", "sexual desire", "weight loss", "constipation", "promotion of heart", "fatigue", "confusion", and "psychomotor". It consists of 20 items of "sexual decline", "psychomotor excitement", "no hope", "frustration", "decision", "self-underestimation", "emptiness", "suicidal ideation", and "dissatisfaction". 3 is about emotions, 8th items from 2nd to 4th to 10th are related to physiological concomitant symptoms, and 10th items from 11th to 20th are related to psychological concomitant symptoms. Consideration was given to self-rating points of 1, 2, 3, and 4 for each question. 40 to 47 points were judged as mild depression, 48 to 55 points were judged as moderate depression, and 56 points were judged. The above is judged to be severe depression.

(3) Mental health test (WHO SUBI)
The mental health (subjective well-being) is diagnosed from the three elements of "mental health (positive emotion)", "mental fatigue (negative emotion)", and "satisfaction". Specifically, 11 subscales (positive feeling for life / sense of accomplishment / self-confidence / bliss / support for relatives / social support / relationship with family / mental control / physical unhealthy feeling) / Lack of social connection / Disappointment with life) evaluates mental health and mental fatigue (40 question items are answered in 3 levels). Not only mental health, but also human relations and physical health are included to comprehensively evaluate mental life.

(4) Insomnia test (Athens Insomnia Scale (AIS))
Consideration is given to self- rating points 1, 2, 3, and 4 for 8 questions related to sleep troubles that have been experienced three or more times a week in the past month, and insomnia is evaluated by the total score. A score of 1 to 3 indicates no worries about sleep disorders, a score of 4 to 5 indicates a slight suspicion of insomnia, and a score of 6 or higher indicates a high possibility of insomnia.

(5) Brain age measurement (A-TMT test)
Press the numbers 1 to 25 on the monitor screen as soon as possible without making a mistake. This measurement is performed twice, and the difference between the actual age and the brain age (measuring device: "Raku-Raku Wellness" manufactured by Wellup Co., Ltd.) and the brain activity were evaluated and analyzed by analyzing the correctness rate and reaction time. ..

(6) Blood vessel age measurement Acceleration plethysmometer (measurement equipment: Blood vessel age was measured by "Raku-Raku Wellness" Wellup Co., Ltd.), and the difference between the actual age and the blood vessel age, evaluation, and analysis were performed.

(7) Determination of brain executive function and measurement of sway of center of gravity Analyze the effects on brain executive function (generally analyze left-right cognition, visual field function, short-term memory, skin sensation, center of gravity balance, etc.) Function meter EF-60" manufactured by Anima Co., Ltd.). Specifically, determine whether the white circle appearing on the computer is on the left or right from the center line, and press the button as soon as possible.Test or determine which of the left and right diaphragms vibrates as soon as possible and press the button. I did a test.

Also, for the purpose of static balance evaluation, which is an index of the fall prevention risk of the elderly, we measured the fluctuation of the body weight that appears in the upright posture, and measured the sway of the center of gravity to evaluate the balance function from the patterns and data. A center of gravity sway meter (measuring instrument: "Brain executive function meter EF-60" manufactured by Anima Co., Ltd.) was used to measure the center of gravity moving distance for 30 seconds while standing still.

≪Each subject's own hydrogen suction and hydrogen suction device≫
For the hydrogen suction of each test subject, an electrolysis type hydrogen gas suction tool 100 (see FIGS. 1 to 3) described later was rented out, and each subject or a caregiver was allowed to do so at home or the like. As described above, the subject can take hydrogen generated by the electrolysis-type hydrogen gas suction device 100 under natural breathing for about 4 weeks, 5 times a day (15 minutes or more for continuous inhalation. Desirably after waking up. After breakfast, after lunch, after dinner, and before going to bed, it was inhaled for several minutes (preferably about 5 minutes) and then returned. The subject attaches the nozzle 5 of the electrolysis-type hydrogen gas suction tool 100 to the mouth or nose to suck hydrogen.

<<Verification and analysis of test results in each test>>
With reference to FIG. 4 for the test results above, the following ones, especially the effect of hydrogen suction is determined to be significant results will be described. The test results of FIG. 4 are the results of calculating the t-test and the amount of effect (r: correlation coefficient) using the method of the before-and-after comparison test before starting hydrogen aspiration (before the intervention) and after continuous hydrogen aspiration (after the intervention). This is a statistically significant analysis of the effect of continuous hydrogen suction from the difference between the average values before and after the intervention (using IBM SPSS Statistics 25).

Fig. 4 is a list of results before and after each of the tests (1) to (7) described above. Here, the local resident woman (Nishinoomote City), which has a large number of elderly people, is symmetrical, and the total number of people in the left column is 86 (n=86). A person (n=7) and right orchid show p value and r value.

In the left and middle columns, M is the average value and SD is the standard deviation. The standard deviation is the positive square root of the variance, and is the magnitude of the variation in each test result for each person. The smaller the standard deviation, the smaller the variation and the effectiveness as data.

The r value (effect amount) is a correlation coefficient that indicates the strength and direction of the relationship between hydrogen suction and each test. When r = ±1, the correlation is strongest, and when ±0, there is no correlation. Is shown. Based on the general theory, r<0.10 has a small correlation (Small), 0.10≦r<0.50 has a medium correlation (Medium), and r≧0.50 has a large correlation. (Large). In addition, the p-value indicates the significant probability, that is, the probability that the result will occur if hydrogen suction is irrelevant to each test (accidental), and the lower the p-value, the more the hydrogen suction is related to the influence in each test. It can be said that it shows that it is doing.

Based on this, when looking at the list of test results in Fig. 4, first, in the MMSE dementia confirmation test, the standard deviation (SD = 2.2) of elderly women living in the area before the intervention, and the area where MIC was suspected before the intervention The average value of resident elderly people (SD=1.2), the standard deviation (SD=1.1) and standard deviation SD of community-dwelling elderly people with suspected MIC after intervention are relatively small, and the correlation coefficient r value ( r=0.84) is large (Large), and it can be seen that hydrogen aspiration clearly affects the improvement of the MMSE dementia confirmation test with a significant probability (p=0.00). Therefore, improvement of cognitive function can be recognized as an effect of continuous hydrogen suction.

Next, in the Depression Scale Test (SDS), standard deviation of community-dwelling elderly women before intervention (SD=2.9) and standard deviation of community-dwelling elderly people suspected to have MIC before intervention (SD=3.8). ), the standard deviation (SD=1.8) and the standard deviation SD of community-dwelling elderly people with suspected MIC after intervention are relatively small, and the correlation coefficient r value (r=0.61) is large (Large), Since the significance probability (p=0.19) is small, it can be seen that hydrogen suction greatly affects the improvement of the depression scale test (SDS). Therefore, the improvement of depression can be recognized as the effect of continuous hydrogen suction.

Regarding “confidence” in the 11 subscales of the mental health test (WHO SUBI), the standard deviation (SD=1.3) of elderly women living in the area before the intervention, and the resident suspected to have MIC before the intervention The standard deviation of the elderly (SD=0.9), the standard deviation of the community-dwelling elderly suspected to have MIC after the intervention (SD=1.1) and the standard deviation SD are small, and the correlation coefficient r value (r=0 .48), which is relatively large (near Large), and has a very small significance probability (p=0.08), an improvement in “confidence” can be recognized as an effect of continuous hydrogen suction.

In addition, in the insomnia test (Athens Insomnia Scale (AIS)), the standard deviation of community-dwelling elderly women before the intervention (SD=3.9) and the standard deviation of community-dwelling elderly people suspected to have MIC before the intervention ( SD=2.1), the standard deviation (SD=1.2) and standard deviation SD of community-dwelling elderly people suspected to have MIC after intervention are relatively small, and the correlation coefficient r value (r=0.50) is Although it is large (Large) and the significant probability (p=0.88) is not small, it can be recognized that it has some effect on the improvement of insomnia as the effect of continuous hydrogen suction.

Moreover, in the brain age measurement (A-TMT test (brain age-actual age)), the standard deviations of the elderly women living in the area before the intervention were respectively (SD=6.9), and the area where the MIC was suspected before the intervention was found. There is a certain variation in the standard deviation (SD=6.3) of the elderly and the standard deviation (SD=8.7) of the community-dwelling elderly suspected to have post-intervention MIC, and a significant probability (p=0. 86), but since the correlation coefficient r value (r=0.05) is small (Small), the improvement of brain age itself could not be recognized from the results of this test as the effect of continuous hydrogen suction.

On the other hand, in the blood vessel age measurement (vascular age-actual age), the standard deviations of community-dwelling elderly women before the intervention (SD=5.1) are respectively (SD=5.1), and the standard deviation of community-dwelling elderly people suspected to have MIC before the intervention ( SD=6.3), standard deviation of community-dwelling elderly people suspected to have MIC after intervention (SD=6.4), and correlation coefficient r value (r=0.54), although there is a certain variation in the data. Is large (Large), and a significant probability (p=0.05) is obtained, which is very small, indicating that hydrogen aspiration significantly affects the results of vascular age measurement. Therefore, improvement of blood vessel age can be recognized as an effect of continuous hydrogen suction.

Furthermore, a remarkable effect of continuous hydrogen suction is recognized in the determination of brain executive function and the measurement of center of gravity sway, especially in the center (Y) direction balance (front-back direction balance) and front-back width (cm) balance in the center-of-gravity sway test. Specifically, the standard deviation of community-dwelling female elderly people before the intervention (SD=1.7, 1.1) and the standard deviation of community-dwelling elderly people suspected to have MIC before the intervention (SD=1.7, respectively). 0.4), the standard deviation (SD=0.9, 0.7) and the standard deviation SD of community-dwelling elderly people with suspected MIC after intervention are small, and the correlation coefficient r value (r=0.61, 0). .61) is large (Large) and the probability of significance (p=0.02, 0.02) is very small, indicating that hydrogen suction has a great influence on the improvement of the sway of the center of gravity.

From the above test results, regular hydrogen aspiration has the effect of improving cognitive function, depression, depression of insomnia, improvement of brain executive functions such as balance of center of gravity. It will be understood that it is expected as one of (preventive care). In particular, if hydrogen stays in the MIC risk zone, the risk of dementia can be greatly reduced, which has great social significance.

<<Electrolytic hydrogen generator>>
Next, the electrolysis-type hydrogen generating tool of the second aspect of the present invention (hereinafter, referred to as “hydrogen generator” as a hydrogen generating apparatus recommended for performing the biological improvement method of improving the daily function and/or cognitive function of the first aspect of the present invention. A typical embodiment of the “electrolytic hydrogen gas suction device” will be described in detail below with reference to FIGS. 1 to 3. However, it goes without saying that the electrolysis hydrogen generator (electrolysis hydrogen gas suction tool 100) of the present invention is not limited to that shown in FIGS. 1 to 3.

FIG. 1 shows a sectional view of the electrolytic hydrogen gas suction tool 100 of the present invention taken along line AA of FIG. 3(c). Further, FIG. 2 is an assembly exploded view illustrating each member of the electrolysis-type hydrogen gas suction tool 100. Further, FIG. 3 is a view of the electrolytic hydrogen gas suction tool 100 of FIGS. 1 and 2 as seen from each direction, where (a) is a left side view, (b) is a front view, and (c) is. Right side view, (d) is a bottom view, and (e) is a top view. In the present specification, the vertical direction and the vertical direction mean the vertical direction and the vertical direction of the paper surface of (b), and the width direction, the horizontal direction, and the lateral direction of the (b) horizontal direction and the paper surface when referred to as the side portion. It means the lateral direction and the left and right sides of the paper.

As described above, FIG. 3 shows a configuration example of each member of the electrolysis hydrogen gas suction device 100. The main body cover 1 is opened upward, and a battery receiving portion 43 into which the entire battery 36 is inserted and built in vertically from the opening, and a reduced diameter portion 45 in the lower portion of the electrolytic cell 10 which is vertically aligned with the battery receiving portion 43. Is a resin case provided with an electrolytic cell receiving portion 44 having a shape capable of being inserted and fitted from above. The battery 36 used here is preferably a rechargeable lithium battery.

The main body cover 1 has a shape in which the battery receiving portion 43 side is long and the upper part on the electrolytic cell receiving portion 44 side is cut out so as to be inclined sideways. The bottom portion of the main body cover 1 including the battery 36 can be opened and closed with the main body bottom cover 6 as a lid member, and the bottom portion of the battery receiving portion 43 can be opened and closed. The bottom of part 43 is closed. The body bottom cover 6 is closed with a screw 38 having a cross hole. The body cover 1 is provided with a space in which two control boards (electronic boards) 33 and 42 are arranged so as to sandwich the battery 36 in the vertical direction on both sides of the battery receiving portion 43. The control board 33 on the side surface side is a main control board, and the control board 42 on the electrolyzer 10 side that supplies electric power to the suction unit 32 (fragrance generator) and the mesh electrode 17 (electrode plate) and the battery to The power supply from 36 is controlled.

A decorative plate 9 is attached to the side surface of the main body cover 1 along the longitudinal side surface, and the decorative plate 9 has a button hole 9a through which the operation button 35 to the control board 33 can be seen in order from above, and light from the LED board 30. An LED hole 9b for irradiation and a charging connector hole 9c for connecting a connector for charging the battery 36 from an external power source are provided.

When the operation button 35 is pressed three times, the main power is turned on, the control board 33 transmits a power supply signal to the control board 42, and the control board 42 causes the power of the battery 36 to pass through the pressure-bonding board 28 to form a pair of mesh electrodes (electrode plates). )17 is ready for supply. At this time, the control board 33 transmits a power supply signal to the power supply LED 30 to cause the LED 30 to emit light (white light when the charge amount of the battery 36 is 80% or more, blue light when the charge amount is 20% to 80%, and charging is performed). If the amount is less than 20%, a red light or blinking light is emitted). This allows the user to visually confirm that the hydrogen gas is being generated and the remaining amount of the battery 36 through the LED hole 9b. Further, when the operation button 35 is pressed again three times, the main power is turned off. The reason for pressing the operation button 35 three times is to turn ON/OFF the main power source when the user puts the electrolysis-type hydrogen gas suction tool 100 in a pocket or the like and moves the button unintentionally. However, it is a safety condition for avoiding generation of hydrogen and the like.

When the operation button 35 is pressed with the main power turned on and the state is maintained (pressed and held), a power supply signal is transmitted to the control board 42 by the control board 33, and the control board 42 causes the battery 36 to be operated. Electric power is supplied to the pair of mesh electrodes (positive and negative electrode plates) 17 via the pressure bonding substrate 28, and when the state where the finger is released from the operation button 35 and released is released, the power supply is stopped. While electric power is being supplied to the mesh electrode 17, the control board 42 irradiates the electrolytic cell 10 by supplying electric power to the electrolytic cell LED 31 to emit blue light. As a result, the user is in the hydrogen gas generation state and can visually recognize that bubbles such as hydrogen are generated from the mesh electrode in the electrolytic cell 10.

The mesh electrodes 17 are arranged in parallel in a longitudinal direction in a pair of two, and each form a positive cathode, and correspond to the electric power from the positive cathode of the battery 36. The upper end of the mesh electrode 17 has a shape that is obliquely cut so as to correspond to the boundary line between the reduced diameter portion 45 of the electrolytic cell 10 and the water storage main body portion 46. The rod-shaped titanium electrode 16 is connected to the lower end of the mesh electrode 17 so that it can stand upright on the terminal substrate 28 and be electrically connected thereto. The packing 13 (made of resin such as silicon) mounted on the terminal substrate 28 to shield the mesh substrate 17 and the terminal substrate 28 from water in a state where the mesh electrode 17 is erected, and an O-ring attached to the periphery of the titanium electrode 16 ( Made of resin such as silicon: the same applies to the O-rings hereinafter).

The electrolytic cell 10 is a water storage container, and a diameter-reduced portion 45 and a water storage main body portion 46 are integrally formed in order from the bottom, and are fluidly connected to each other inside. The water storage main body portion 46 is opened upward so that water can be poured therein, and is semi-closed by attaching the electrolytic cell lid 12. The electrolytic cell lid 12 penetrates vertically and is provided with a through opening 12a for receiving the umbrella valve 23, the screw cap 14, and the like. As shown in FIG. 1, the water storage main body portion 46 has an outer portion 46a that forms a laterally substantially flat side wall from the upper end to the lower end and is directly connected to the upper end of the reduced diameter portion 45. The upper portion 46b is formed in parallel to the outer portion 46a from the upper end to the central lower position, and has a bottom portion 46c that is bent and inclined from the central lower position. The bottom portion 46c extends to an intermediate position in the lateral direction and connects to the upper end of the reduced diameter portion 45.

Further, the diameter-reduced portion 45 is thinner than the water storage main body portion 46 as described above, and the upper end of the outer side portion 46a on the side wall side is directly attached to the lower end of the outer side portion 46a of the water storage main body portion 46 as shown in FIG. It continuously connects and extends to the lower end, and the upper end of the inner portion 45b of the reduced diameter portion 45 on the main body cover 1 side is bent downward at the position of the tip (edge) of the bottom portion 46c of the water storage main body portion 46 to be connected. And extends to the lower end in parallel with the inner portion 45b.

Further, at the connecting position of the lower end of the outer side portion 46a of the water storage main body 46 and the upper end of the outer side portion 46a of the reduced diameter portion 45, a partition plate 45d is provided which is inclined substantially the same as the bottom portion 46c of the water storage main body portion 46 and extends to the opening 45c. Has been. The partition plate 45d extends over the entire inside in the direction perpendicular to the paper surface of FIG. Therefore, even if the amount of stored water is reduced due to electrolysis of the aqueous solution stored in the electrolytic cell 10, water will always be stored in substantially the entire area inside the reduced diameter portion 45. Specifically, when the amount of stored water is reduced and a partial air layer is formed in the electrolytic cell 10, first, since the diameter-reduced portion 45 is thinner than the stored water body 46, in a normal standing state, unless the amount of stored water is significantly reduced. The reduced diameter portion 45 is filled with water and no air layer is generated.

Even if the water storage amount is reduced to some extent, an air layer may be generated in the reduced diameter portion 45 when the present hydrogen gas suction device 100 is inclined or placed horizontally, but in the case of the present electrolytic cell 10, this is the case. Even in the case, the reduced diameter portion 45 is filled with water. Specifically, for example, when tilted to the left in the plane of FIG. 1, the bottom portion 46c serves as a baffle plate and an air layer is formed on the inner portion 46b side of the water storage main body portion 46. On the contrary, when tilted to the right in the plane of FIG. 1, the partition plate 45d serves as an obstacle and an air layer is formed only on the outer side 46a side of the water storage body 46. Therefore, the entire mesh electrode 17 disposed in the reduced diameter portion 45 is always in contact with water, and the hydrogen generation amount can always be secured even when the user sucks it sideways.

The upper end edge of the mesh electrode 17 is formed by obliquely cutting along the shapes of the reduced diameter portion 45 and the opening 45c so that the entire electrode is immersed in water in the reduced diameter portion 45. Returning to FIG. 3 again, the lower end of the electrolytic cell 10 is closed by the electrolytic cell bottom 11, and the electrolytic cell bottom 11 is provided with a pair of through holes into which the mesh electrodes 17 are inserted, and the reduced diameter portion 45 of the electrolytic cell 10 is provided. When is inserted into the electrolytic cell receiving portion 44 of the cover body 1, the mesh electrode 17 passes through the through hole of the electrolytic cell bottom 11 and is positioned in the reduced diameter portion 45.

The umbrella valve 23 and the like mounted on the through opening 12a of the electrolytic cell lid 12 at the upper end of the electrolytic cell 10 will be described. A screw cap 14 having an opening on the upper side and penetrating vertically is attached to the through opening 12a. At that time, a vent filter 18 is interposed between a hole at the bottom of the screw cap 14 and the bottom of the through opening 12a. Then, the O-ring 21 is inserted around the lower portion of the screw cap 14. The vent filter 18 has a function of waterproofing/dustproofing while adjusting the internal pressure in the opening of the screw cap 14 with a minute hole. Further, the O-ring 21 blocks water between the outer peripheral wall of the opening of the screw cap 14 and the inner peripheral wall of the through opening 12a.

Further, an umbrella valve 23 (made of a flexible material such as silicon) that operates in the vertical direction is attached in the opening of the screw cap 14, and when a user sucks the nozzle 5 (described later) and a negative pressure acts upward. The ampule valve 23 moves upward and fluidly connects to the inside of the electrolytic cell 10 through the through hole at the bottom of the screw cap 14 and the through opening 12a of the electrolytic cell lid 12. Therefore, when the nozzle 5 is sucked, the hydrogen gas ascended and stored in the electrolytic cell 10 is released to the outside. On the contrary, when the user interrupts the suction and the negative pressure does not act, the ampulera valve 23 descends, the through hole at the bottom of the screw cap 14 is closed, and the release of hydrogen gas in the electrolytic cell 10 is closed.

The mixer 2 is attached from above to the electrolytic cell lid 12 to which the screw cap 14 and the umbrella valve 20 are attached. The mixer 2 has a tubular member 2a extending downward as shown in FIG. 1, and the lower end of the tubular member 2a is inserted into the opening of the screw cap 14 so that the tubular member 2a receives hydrogen from the umbrella valve 23. A flow path is formed to guide the gas upward. An O-ring 20 is provided around the outer peripheral wall of the tubular member 2a, and seals the gap between the inner wall of the opening of the screw cap 14 and the tubular member 2a of the umbrella valve 23.

Securing the mixer 2 and the electrolytic cell lid 12 is done by attaching lock buttons 3 and 4. The lock buttons 3 and 4 are respectively sandwiched and snap-fastened in the front-rear direction (the direction perpendicular to the paper surface of FIG. 9) at the vertical gap between the mixer 2 and the electrolytic cell lid 12. Further, as shown in FIG. 1, the mixer 2 is provided with a flow path 2b in the upper part thereof toward the nozzle 5. This flow path 2b is connected to the flow path formed by the tubular member 2a and guides hydrogen gas as shown by the arrow in FIG.

Next, although not desired as the electrolysis-type hydrogen gas suction tool 100 as a hydrogen generator for carrying out the bioactivation method for promoting the nerve activity and/or blood circulation activity of the living body of the present invention, the user can use it on a daily basis. An aroma heater portion 32 for generating aroma air may be provided to satisfy the preference when used.

First, the contact terminal 37 of the battery 36 is inserted into the upper end opening of the battery receiving portion 43 of the main body cover 1. The contact terminal 37 is formed by connecting the bottom of the large-diameter cylinder and the upper part of the small-diameter cylinder, and the bottom is inserted into the opening at the upper end of the battery receiving portion 43 to supply electric power from the battery 36 to the fragrance heater portion 32. The contact terminal 37 is fastened to the joint 7 from above with a screw 38 having a cross hole. The joint 8 is formed by connecting a bottom portion of a small diameter cylinder and a top portion of a large diameter substantially disc shape, and the top portion of the contact terminal 37 and the bottom portion of the joint 38 are fitted in a nested manner.

The aroma heater member 32 is placed on the upper surface of the joint 8, and when the mixer 2 is attached, it is sandwiched between the joint 8 and the mixer 2 and fixed to the main body cover 1. The fragrance heater member 32 is a general-purpose device, and when power is supplied, fragranced air is generated inside and is discharged upward. Further, the mixer 2 is provided with a tubular member 2c extending in parallel with the above-mentioned tubular member 2a, and the upper end of the aroma heater portion 32 is connected to the tubular member 2c. Therefore, the fragranced air discharged from the fragrance heater portion 32 passes through the tubular member 2c as shown by the arrow in FIG. 9, and joins with the hydrogen gas flowing through the flow passage 2b through the tubular member 2a. It flows into the nozzle 5 and is discharged into the mouth of the user.

The nozzle 5 has a structure in which a large-diameter disk member at the bottom and a tubular member at the top are integrally connected, and the bottom thereof is fluidly connected to the tubular member 2c of the heater 32 of the mixer 2. Mounted on the surface opening. As a result, hydrogen gas from the flow path 2b and/or fragranced air from the tubular member 2c is discharged from the inside of the nozzle 5 to the outside of the upper end. An O-ring 22 is arranged and sealed at the connection between the bottom of the nozzle 5 and the mixer 2.

Further, in the fragrance heater section 32, the power supply from the battery 36 is controlled by the control board 33. As described above, the power to the mesh substrate 17 is supplied for a predetermined time when the button 35 attached to the main body cover 1 is pressed three times. On the other hand, when the button is pressed and held, the contact terminal 37 is connected on condition that the power supply signal to the mesh electrode 17 is not transmitted from the control board 33, and the power from the battery 36 is supplied to the aroma heater 32 for a predetermined time. It

Therefore, when the user inhales the nozzle 5 by pressing the button 35 three times, hydrogen gas is released from the nozzle 5, and the user can enjoy the hydrogen gas suction for a predetermined time (while the LED substrate 30 emits light), and the hydrogen gas You can enjoy the hydrogen gas with fragrance by long pressing the button 35 while it is being released.

As described above, the living body improving method for improving the living function and/or cognitive function of the present invention, and the embodiment of the electrolytic hydrogen generating device (electrolytic hydrogen gas suction device) suitable for carrying out this method are exemplified. Although the present invention has been described, the present invention is not limited thereto, and those skilled in the art can obtain other modifications and improvements without departing from the spirit and teaching of the claims and the specification. Will understand.

According to the bioimprovement method for improving the living function and/or cognitive function of the present invention, and the electrolytic hydrogen generating device suitable for carrying out this method, mild cognitive impairment (MCI) is caused by regular inhalation of hydrogen. Improve the living and/or cognitive functions of middle-aged and elderly people, including those with suspected brain and physical functions, and reduce the burden of care insurance business through preventive care such as dementia, and preventive care It is possible to contribute to the expansion of the medical market by providing a contributing device.

100 Electrolytic hydrogen gas suction tool 1 Body cover
2 Mixer (mixer)
5 Nozzle 10 Electrolytic Bath 12 Electrolytic Bath Lid 14 Screw Cap 17 Mesh Electrode (Cathode) Container Body 22 O Ring 23 Mesh Electrode (Anode)
32 Fragrance heater part (fragrance heater member)
33 battery 42 control board 45 reduced diameter portion 45c partition plate 46 water storage main body portion

Claims (6)

1. A bioimprovement method for improving daily functions and/or cognitive functions by regularly orally or nasally inhaling high-concentration hydrogen-containing air using a portable electrolysis hydrogen generator.
2. The method for improving a living body according to claim 1, wherein the high-concentration hydrogen-containing air is aspirated at intervals of approximately 15 minutes or more, 5 times or more every day for a predetermined time, and continued for approximately 4 weeks or more.
3. A portable electrolyzed hydrogen generator used for improving the daily function and/or cognitive function by inhaling orally or nasally a high concentration hydrogen-containing air,
   A main body cover member including a battery, a control substrate that controls power supply from the battery, and a pair of positive and negative electrodes that energize or shield the anode and the cathode by the control substrate,
   A transparent or semi-transparent electrolytic cell which is attached to the main body cover member, in which the pair of positive and negative electrodes is inserted, and which can store water;
   A mixing section which has a flow path for taking in ambient air while fluidly connecting a nozzle section capable of oral or nasal suction while gripping with one hand and the electrolytic cell,
   An operating unit that can be operated while holding the electrolytic hydrogen generator with the one hand,
   Equipped with
   The control board is an electrolysis-type hydrogen generator, which controls the supply and stop of power from the battery to the positive and negative electrodes by operating one operating means.
4. The operating means is a button type that can be pressed, and when it is continuously pressed a plurality of times, it sends an ON/OFF signal of a main power source to the control board, and when the main power source is in an ON state, it is pressed and the pressed state is maintained. The electrolysis hydrogen according to claim 3, wherein the control substrate supplies electric power from the battery to the positive and negative electrodes and controls so as to stop the electric power supply from the battery to the positive and negative electrodes when the pressed state is released. Generator.
5. The control board presses the operation button in a main power ON state, and controls so as to stop power supply from the battery to the positive and negative electrodes when a preset time elapses in the pressed state. Electrolytic hydrogen generator.
6. An LED for irradiating the electrolytic cell,
   The electrolytic hydrogen generator according to any one of claims 3 to 5, wherein the control board energizes the LED when power is supplied from the battery to the positive and negative electrodes.
   

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