WO2020096539A2 - Technique de transplantation capillaire qui réduit le processus de pousse des cheveux et permet d'obtenir un plus grand nombre de follicules pileux - Google Patents

Technique de transplantation capillaire qui réduit le processus de pousse des cheveux et permet d'obtenir un plus grand nombre de follicules pileux Download PDF

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Publication number
WO2020096539A2
WO2020096539A2 PCT/TR2019/000070 TR2019000070W WO2020096539A2 WO 2020096539 A2 WO2020096539 A2 WO 2020096539A2 TR 2019000070 W TR2019000070 W TR 2019000070W WO 2020096539 A2 WO2020096539 A2 WO 2020096539A2
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WIPO (PCT)
Prior art keywords
hair
grafts
vitamin
follicles
area
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PCT/TR2019/000070
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English (en)
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WO2020096539A3 (fr
Inventor
Yilmaz KAHRAMAN
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Kahraman Yilmaz
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Publication of WO2020096539A2 publication Critical patent/WO2020096539A2/fr
Publication of WO2020096539A3 publication Critical patent/WO2020096539A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/3205—Excision instruments
    • A61B17/32053—Punch like cutting instruments, e.g. using a cylindrical or oval knife
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00752—Hair removal or transplantation

Definitions

  • HiAIR TRANSPLANTATION TECHNIQUE THAT REDUCES THE HAIR GROWTH PROCESS AND REACHES A HIGHER NUMBER OF HAIR FOLLICLE
  • the present invention is a hair transplantation technique that reduces the Mir growth process, reaches a higher number of hair follicles in one session and increases hair growth success despite genetic causes.
  • Patent no. JPS5465659 belongs to 1979 and refers to a method covering a total of 6 stages related to hair transplantation.
  • the hair strands are held together with a resin plate to be defined in a rainbow-type bulging form.
  • This part is in an inlet space and has a section with wing-shaped opening after the inlet space which facilitates holding.
  • the document is mainly concerned with the most primitive technique of hair transplantation.
  • Patent no. JPS5921610 belongs to 1984 and relates to a nutritious formula to aid hair growth. It relates to hair tonic which consist an oxidizing component containing an active ingredient which reduces hair loss by eliminating the reduced lW5a reductase enzyme activity present in the sebaceous glands.
  • the hair tonic component according to claim l is selected from the oxidizing agent, stabilized chlorine dioxide, sodium bromatc, sodium perborate, potassium inornate.
  • the stabilized chlorine dioxide content was determined to be 10Q or 500 ppm.
  • the content of sodium bromate in the hair tonic component is stated to range from 50,000 to 120,000 ppm ami the potassium bromate content is 5% to 12%.
  • the invention relates to a tonic that promotes hair growth and prevents hair loss, and this is a well-known component and its effect on the growth of the hair is seen over a long period of time.
  • FUE Fibre Unit Extraction
  • FT Fibre Transfer
  • known techniques among hair transplantation methods are the methods used for obtaining hair follicles from the donor area and repositioning them in the alopecia region.
  • grafts are removed from the hair strands behind the head. These grafts are hair follicles consisting hairs between 1 to 4. These grafts are then transferred to the scraped scalp.
  • the hair follicles are taken from the back of the head with a single hollow needle or pliers (drills), and these toots are placed in areas of need or in several parts of the head. This is done by means of a hollow needle or a small cup.
  • transplanted hair is shed after approximately 3-6 weeks and then they grow again after 3- 4 months. The actual results take 12-18 months. This applies to the FUE method.
  • FUE Ficular Unite Extraction
  • the area where the hair is to be sown is defined when the hair is long. After the area is determined, the hair is shortened to the required length. The reason for this shortening is to ensure that the hair is removed by punches.
  • the punches are medical devices that have spikes of different sizes similar to penpoints that allow the hair follicles to be loosened and collected by micro-pen-set.
  • the region where the grafts will be taken is determined and local anesthesia is started. Then, the punch is selected in accordance with the patient's graft density and the direction of the graft, and the collection process starts. Punch selection is an important parameter in order to take the grafts without damage. The grafts taken are kept in special solutions by adjusting the appropriate temperature of the medium.
  • grafts Ihe main structure that is taken from behind the head during hair transplantation and planted in hair-loss areas. There are hair follicles and some skin in the graft and it varies according to the number of hair follicles and the amount of skin it contains. Hair follicles in the graft can be found as single, double, triple or quadruple. Hair follicles are the area of the living cells that produce and grow the hair.
  • grafts are exclusively taken from the person itselfi grafts taken from someone else cannot live and hairs will not come out.
  • the area where the hair will be transplanted is defined after grafts are taken, then the line is determined.
  • I Ocal anesthesia is applied to the area to be planted and the grooving is started.
  • the direction and density of the hair to be planted is determined by the channels in this stage.
  • Serum is injected into the areas selected by the patient, which is specially prepared for grooving; and with this step the grooving process starts.
  • the shafts in which the hair follicles will be placed during the sowing process are called channels and these shafts are formed with fine incisions. This process is created with the help of special tools called lateral slit/slit Different tools are used in these opening processes because the hair follicles used in the front and the top areas are not the same.
  • slit should be done in a way that is appropriate to the grafts. Slit which is larger than required leads to cavities at the depth of the hair, and slits smaller than required leads to the harming of grafts at the sowing stage.
  • the density of the canals should be such that it will not cause circulatory disorder in the sowing ansa after sowing. If this density is not adjusted correctly, the number of lost hours after sowing may increase.
  • the grafts taken are placed one-by-one in the channels which are opened with precision without damaging them with sowing forceps, and the sowing process is completed.
  • the hair transplanted with hair transplantation lasts permanently for life. Hair to be used in the process is usually taken from the back of the head. The hair growing in this area are not lost, even in the case of serious hair loss.
  • the hair in the heiar line and in the temples will retain their genetic characteristics. Thanks to hair transplantation, hair regrowth is ensured in hairless areas.
  • the hair follicles are taken one-by-onc from the back of the head with the help of a hollow needle or pliers (drill); the follicles taken are placed on the requiring areas or on several parts of the head. This is done by means of a hollow needle or a small cup.
  • the transplantation is done, and the transplanted hair is shattered after approximately 3-6 weeks and then the hair grows again after 3-4 months. The main results are obtained in a period of 12-18 months.
  • Hair transplantation is made to the second layer of the three layers under the skin, but determining the correct depth is the most important factor for the permanence of the hair transplanted.
  • the layers under the skin are as follows; epidermis, dermis and subcutaneous.
  • the hair transplantation is made to mentioned second layer, the Dermis.
  • due to the anatomical structure of the head it is not possible to open the canals without damaging the existing hair in the areas which has not got bald but where the hair get thinner.
  • Application of grooving by harming the hair follicles owned by the donor does not yield healthy results; rather it can also lead the opposite effects.
  • the invention which is a hair transplantation technique that reduces the hah growth process, reaches a higher number of hair follicles in one session and increases hair growth success despite genetic causes, completely overcomes the above problems and provides an earlier achievement of final result in the hair transplantation process.
  • the AS! method of the invention eliminates the grooving process due to the fact that it is not possible to open channels without damaging the existing hair in areas where the hair is still dense, especially in the areas which are not becoming bald, but where the hair get thinner, and it allows the injection of the solution of processed hair follicles underneath tire scalp to the required depth.
  • the invention consists of a new technique called FUE-CT (Circulation Treatment) to reduce the process of hair growth and reach a higher number of hair follicles in one session and increase hair success despite genetic causes.
  • FUE-CT Cosmetic Treatment
  • the final result takes about 6-9 months, and it significantly reduces the time to achieve results in hair transplantation.
  • the duration of hair growth is reduced, and it reaches to the higher number of hair follicles in a single session and increases hair success despite genetic reasons.
  • This method unlike the FUE method applied today, contains two separate methods. These are called Cl'S (circulation treatment stimulator) and AS! (anti shock loss implantation).
  • CTS circulation treatment stimulator
  • DHT dihydrotestosterone
  • the CTS treatment also minimizes temporary hair loss in the donor area and in the hair-transplanted area with the shock loss.
  • Multi-grafts are used in the FUE CT technique.
  • 70% or more multi-grafts (3 or more hair follicles) are used in people having healthy donor areas, resulting in a denser result of 2-fo!d or higher.
  • punches in acceptable thickness are used to prevent the development of problem in the recovery of the donor area.
  • 8000-9000 hair follicles can be planted with 3000 grafts.
  • the channels are opened to the safe depth where the blood circulation in the scalp will be the strongest, and the multi grafts are placed here. This depth can vary from person to person and the channel-opening expert determines this depth by his/her experience. If the rate of bleeding is very slow here, the blood circulation is promoted by CTS stimulants.
  • FUE CT mineral and vitamin pills are started and used for 9-12 months until the result is achieved. These tablets will supplement the lack of vitamins and minerals necessary for the formation of hair in the body. Some substances will also promote blood circulation in the scalp, CTS treatment has a great effect on improving the weak appearance of the existing hair.
  • the scabs are washed with special shampoos and lotions, and the skin is completely cleaned.
  • shampoo should be changed to FUE CT hair shampoo and used for 9-12 months until the result is achieved.
  • the active ingredients in this shampoo will support the circulation in the scalp and support the healthy hair structure.
  • the CTS (Circulation Therapy Stimulator) treatment which provides die biggest support in hair growth, must be applied once within 4-6 weeks without «tiering interval between 6-10 weeks, which we say to be the hair follicle adaptation period.
  • the second CTS session should be applied between 4-6 montits when the hair starts to appear.
  • CTS the blood circulation in the scalp is accelerated and the necessary vitamins and stimulants are injected under the skin so that the process is passed without loss and rapidly.
  • the CTS treatment can be applied up to 12 months at 6 weeks intervals. Since the CTS formula is completely biological, it has no side effects and can be applied in every 4 weeks.
  • the results are taken within 6 to 9 months.
  • the results of the hair on the top can sometimes be achieved in 12 months, It is observed that the thickness of the implanted hair is generally thicker than the existing hair and it grows healthier.
  • the result of hair growth in the FUE technique is observed between 12-18 months and it generally remains structurally thinner when compared to FUE CT results.
  • Each hair transplantation is performed according to a strict protocol and the protocols to be applied may vary in each operation.
  • the operator decides which type of groover/punch/knife to use depending on the thickness / area of the skin (head / forehead), (slit, cannula, injector, etc. or method of injecting hair follicles into foe hairy area, application of ASl technique, CTS (Circulation Treatment Stimulator) substances applied on the skin or under the skin.
  • CTS Cosmetic Treatment Stimulator
  • a small number of channels are opened to the problem area and grafts are planted in those areas arid hair follicle solution is injected through those points by the ASI technique. In this way, a high number of hair follicles are placed at the required depth without damaging the surrounding hair,
  • CTS substances are applied to the plantation areas to increase the shock loss resistance and to provide better treatment
  • These weak grafts are reproduced with healthy grafts and treated as follows; the dermal papillae under the hair follicles are isolated and mixed with selected hair follicles in special conditions to homogenize and form a solution.
  • This solution contains various vitamins, minerals and CTS stimulants.
  • Dermal papillary have a large effect on their environment, from their ability to move the cells above, to transform into a new hair follicle.
  • This solution (melted papillae and processed hair follicles) is injected into a safe depth of the dermis layer through the spots which are hairy but sparse due to getting thinner and ensure its re-growth in here.
  • the preservative body located around the hair follicle contains substances that accelerate the healing of processed hair follicles.
  • follicular anatomy For a rational evaluation of hair diseases, follicular anatomy should be well known.
  • the hair structure can be easily examined through the cut hair follicle shafts, all hairs which are ruptured by slightly pulling or strongly pulling from the skull, or scalp biopsies to be firactioned perpendicularly or transversely.
  • the anatomical features will vary depending on whether the hair concerned is in anagen, catagen or telegonous stage.
  • the follicle size will also vary similarly from the thin veil us hair to the long, thick terminal hair.
  • a follicle can be divided into different regions: root, above-root area (supra-bulbar area), isthmus and infundibulum.
  • the character of the actively growing (anagen) hair is a hair matrix surrounding the dermal papilla; outer and inner root covers are present and well developed.
  • a catagenie hair can be detected with a significantly thickened glassy and fibrous root; the root in question surrounds a column of epithelium.
  • a possible bristle shaft is formed at the top of the column.
  • the distinctive feature of the telogen hair is the folly keratinized hair shaft surrounded fay an epithelium sac.
  • Hair dermal papilla cells are the mesenchymal cells found in the dermal papillae located at the bottom of the hair follicles.
  • Hair follicle formation is generally stimulated by the convergence of dermal mesenchymal cells, the origin of dermal papilla cells, on the embryonic skin.
  • Hair dermal papilla cells are the mesenchymal cells found in the dermal papillae located at the bottom of the hair follicles.
  • Hair follicle formation is generally stimulated by the convergence of dermal mesenchymal cells, the origin of dermal papilla cells, on the embryonic skin.
  • cultured dermal papilla cells also have say activity, and that if the culture process ts carried out with keratinocyte-source conditioned medium obtained from the base, or a medium containing fibroblast growth factor, it does not lose the activity even during long-term processing.
  • die factors secreted by keratinocyte and fibroblast growth factor are important for Even if the hair follicles were taken in vivo together with the hair matrix and dermal papillae from the vibrissa!
  • a new hair matrix and papilla may be formed from the rest of the follicle, and a hair shaft grows again in time.
  • Dermal papilla cells and highly possibly dermal sheath cells are capable of inducing and forming hair follicles in favorable ambient conditions.
  • This instrument is used to inject CTS stimulators into a depth of 1 and / or 4 mm (the depth that can vary depending on the individual’s skin's structure and condition). The process takes approximately 20-30 minutes.
  • -CTS therapy provides rapid healing of donor site (donor area), strengthening of weak grafts and accelerating blood circulation of head skin.
  • the hair transplantation is presented as a whole package/system (graft removal, separation procedure (single / multiple graft)) by a specialized team; the graft is placed considering foe proper growth of the depth and placement channels and the hair follicle. Then it is very important to stimulate with extra vitamin cure and special shampoo and to apply CTS treatment in the required periods.
  • the application of this technique enhances the absorption capacity of vitamins and minerals, hair follicles and anti-radical activity.
  • the technique is supported with extra vitamins and special shampoos that increase the result.
  • the content of the elements used as auxiliary agents in the treatment of hair transplantation is as follows.
  • CT shampoo Water, iauryi glucoside, coco-glucoside, coamidopropyl betaine, citric acid, sodium benzoate, perfume (natural), potassium sorbate, glyceryl oleate, hydrolyzed wheat protein, niacinamide, msm (methylsulfonyimethane), «ticca, keratin, caffeine, vitamin D3, vitamin E, vitamin b!2, b6, bl, pyiidoxinehydrochloride, aloe barbadensts leaf juice, panthenol.
  • CTS stimulator Water, Phenoxyethanol, Glutathione, Tocopherol, Menaquinone-7, Panthenol, Biotin, Ethylhexyl glycerin, sodium hyluronate, vitis vinifera, methylstlanol mannuronate.
  • the hair strands in the skull are composed of hair follicles that are embedded in the skin and the hair body in free state.
  • the epidermis (3) section of the skin is the section that is visible from the outside and contains the exit section of the hair strands.
  • Dermis (4) is the layer where the blood vessels and hair follicles of the sebaceous glands are located » and grooving and transplantation is performed in this layer.
  • the subcutaneous layer (5) is the section containing the fat tissue and blood vessels. Injection of the grafts (2) into the dermis (4) layer without grooving is done by means of the injector (1) shown in the figures, from the reception area (7) which is predetermined within the donor area (6).
  • the injector (1) injects toe grafts (2) from the injection edge (1.1) to toe layer of dermis (4) in the sowing area (8) at the appropriate level (1) without performing any cut-off which is the result of grooving in the layer of toe cpidemtis (3) and dermis (4) .
  • the weak or damaged grafts (2) are converted into an emulsion mixture and (he grafts (2) which have been converted into toe emulsion mixture are then separated by the injectors (1) into the donor and transplantation area.
  • the injector (I) consists of the injection edge (1.1) and (he pull-push edge (1.2).
  • the prepared grafts (2) are drawn into toe injector (1) by toe absorption of the grafts (2) to toe injector (1 ) from the injection edge (1.1) in desired amounts by pulling the pull-push edge.
  • the following embedding into dermis layer (4) is made by pushing the pull-push edge (1.1) with the injector (1) and moving toe grafts (2).

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Abstract

La présente invention concerne une technique de transplantation capillaire qui réduit le processus de pousse des cheveux, permet d'obtenir un plus grand nombre de follicules pileux en une session et accroît la réussite en matière de croissance des cheveux en dépit des causes génétiques.
PCT/TR2019/000070 2018-11-09 2019-10-09 Technique de transplantation capillaire qui réduit le processus de pousse des cheveux et permet d'obtenir un plus grand nombre de follicules pileux WO2020096539A2 (fr)

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TR201816935 2018-11-09
TR2018/16935 2018-11-09

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WO2020096539A2 true WO2020096539A2 (fr) 2020-05-14
WO2020096539A3 WO2020096539A3 (fr) 2020-06-18

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113679828A (zh) * 2021-08-25 2021-11-23 佛山市第一人民医院（中山大学附属佛山医院） 一种伤口清洗液及其制备方法和应用
CN114224442A (zh) * 2021-12-07 2022-03-25 赵佳峰 一种提高毛囊存活率的头发移植器
CN115475111A (zh) * 2022-09-23 2022-12-16 上海纳米技术及应用国家工程研究中心有限公司 一种搭配微针使用的生发原液及其制备方法和应用

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GB2461021A (en) * 2008-06-10 2009-12-23 Ajit Lalvani Composition for the treatment of hair loss and baldness
EP2648676A4 (fr) * 2010-12-06 2016-05-04 Follica Inc Procédés destinés à traiter la calvitie et à favoriser la croissance des cheveux
FR2970868B1 (fr) * 2011-01-31 2023-10-27 Sederma Sa Extrait d'origine vegetale, composition le contenant, procede d'obtention par culture vegetale et utilisations dans les domaines cosmetique, pharmaceutique et cosmeceutique
KR20180114246A (ko) * 2011-04-06 2018-10-17 마리 케이 인코포레이티드 식물 추출물을 포함하는 국소 스킨 케어 제형
DE102012219583A1 (de) * 2012-10-25 2014-04-30 Henkel Ag & Co. Kgaa Haarpflegemittel mit ausgewählten aminofunktionalen Silikonen und ausgewähltem kationischen Keratinhydrolysat

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113679828A (zh) * 2021-08-25 2021-11-23 佛山市第一人民医院（中山大学附属佛山医院） 一种伤口清洗液及其制备方法和应用
CN114224442A (zh) * 2021-12-07 2022-03-25 赵佳峰 一种提高毛囊存活率的头发移植器
CN114224442B (zh) * 2021-12-07 2023-11-24 灶灶科技有限公司 一种提高毛囊存活率的头发移植器
CN115475111A (zh) * 2022-09-23 2022-12-16 上海纳米技术及应用国家工程研究中心有限公司 一种搭配微针使用的生发原液及其制备方法和应用

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