WO2020077289A3 - Procédé de production de réactifs polymères libérables - Google Patents

Procédé de production de réactifs polymères libérables Download PDF

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Publication number
WO2020077289A3
WO2020077289A3 PCT/US2019/055971 US2019055971W WO2020077289A3 WO 2020077289 A3 WO2020077289 A3 WO 2020077289A3 US 2019055971 W US2019055971 W US 2019055971W WO 2020077289 A3 WO2020077289 A3 WO 2020077289A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymeric reagents
fluorenyl
methods
based polymeric
prepared
Prior art date
Application number
PCT/US2019/055971
Other languages
English (en)
Other versions
WO2020077289A2 (fr
Inventor
Sean M. Culbertson
Samuel P. Mcmanus
Antoni Kozlowski
Venkata SOMU
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Priority to US17/284,378 priority Critical patent/US11932726B2/en
Priority to CN201980067645.8A priority patent/CN112839979B/zh
Priority to JP2021518960A priority patent/JP2022512627A/ja
Priority to MX2021004179A priority patent/MX2021004179A/es
Priority to CA3112834A priority patent/CA3112834A1/fr
Priority to KR1020217010246A priority patent/KR20210077677A/ko
Priority to EP19797478.5A priority patent/EP3864068A2/fr
Priority to AU2019358201A priority patent/AU2019358201A1/en
Publication of WO2020077289A2 publication Critical patent/WO2020077289A2/fr
Publication of WO2020077289A3 publication Critical patent/WO2020077289A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
    • C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/46—Post-polymerisation treatment, e.g. recovery, purification, drying

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Polyethers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne (entre autres) des procédés améliorés de préparation de réactifs polymères à base de fluorényle, des procédés de récupération et de purification de tels réactifs polymères, des procédés de réduction d'impuretés indésirables dans un réactif polymère à base de fluorényle, des réactifs polymères à base de fluorényle préparés selon les procédés décrits dans la description, et des conjugués préparés par réaction avec des réactifs polymères à base de fluorényle préparés selon les procédés décrits ici.
PCT/US2019/055971 2018-10-11 2019-10-11 Procédé de production de réactifs polymères libérables WO2020077289A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
US17/284,378 US11932726B2 (en) 2018-10-11 2019-10-11 Method of making releasable polymeric reagents
CN201980067645.8A CN112839979B (zh) 2018-10-11 2019-10-11 制备可释放聚合物试剂的方法
JP2021518960A JP2022512627A (ja) 2018-10-11 2019-10-11 遊離可能な高分子試薬を作製するための方法
MX2021004179A MX2021004179A (es) 2018-10-11 2019-10-11 Metodo para preparar reactivos polimericos liberables.
CA3112834A CA3112834A1 (fr) 2018-10-11 2019-10-11 Procede de production de reactifs polymeres liberables
KR1020217010246A KR20210077677A (ko) 2018-10-11 2019-10-11 방출 가능한 중합체성 시약의 제조 방법
EP19797478.5A EP3864068A2 (fr) 2018-10-11 2019-10-11 Procédé de production de réactifs polymères libérables
AU2019358201A AU2019358201A1 (en) 2018-10-11 2019-10-11 Method of making releasable polymeric reagents

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862744512P 2018-10-11 2018-10-11
US62/744,512 2018-10-11

Publications (2)

Publication Number Publication Date
WO2020077289A2 WO2020077289A2 (fr) 2020-04-16
WO2020077289A3 true WO2020077289A3 (fr) 2020-06-11

Family

ID=68425321

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/055971 WO2020077289A2 (fr) 2018-10-11 2019-10-11 Procédé de production de réactifs polymères libérables

Country Status (9)

Country Link
US (1) US11932726B2 (fr)
EP (1) EP3864068A2 (fr)
JP (1) JP2022512627A (fr)
KR (1) KR20210077677A (fr)
CN (1) CN112839979B (fr)
AU (1) AU2019358201A1 (fr)
CA (1) CA3112834A1 (fr)
MX (1) MX2021004179A (fr)
WO (1) WO2020077289A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7269343B2 (ja) * 2019-07-01 2023-05-08 富士フイルム株式会社 光検出素子、光検出素子の製造方法、イメージセンサ、分散液および半導体膜

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001045796A2 (fr) * 1999-12-22 2001-06-28 Shearwater Corporation Procede de preparation d"esters de 1-benzotriazolyl carbonate de poly(ethylene glycol)
US8252275B2 (en) * 2005-06-16 2012-08-28 Nektar Therapeutics Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
US20120318701A1 (en) * 2006-07-21 2012-12-20 Nektar Therapeutics Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom
US20130225789A1 (en) * 2012-02-29 2013-08-29 Yi Sun Polyethylene Glycol Having Hetero Multiple Functional Groups
EP3279236A1 (fr) * 2015-03-31 2018-02-07 NOF Corporation Dérivé de polyéthylène glycol biodégradable ayant un lieur benzylidène acétal cyclique

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629384A (en) 1994-05-17 1997-05-13 Consiglio Nazionale Delle Ricerche Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
CA2533702C (fr) 2003-07-22 2012-05-22 Nektar Therapeutics Al, Corporation Methode pour preparer des polymeres fonctionnalises a partir d'alcools de polymere
KR101354244B1 (ko) 2005-07-29 2014-02-18 넥타르 테라퓨틱스 폴리(에틸렌 글리콜) 의 카르보네이트 에스테르를 제조하는방법
EP1968644B1 (fr) * 2005-12-16 2012-06-27 Nektar Therapeutics Conjugues polymeres de glp-1

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001045796A2 (fr) * 1999-12-22 2001-06-28 Shearwater Corporation Procede de preparation d"esters de 1-benzotriazolyl carbonate de poly(ethylene glycol)
US8252275B2 (en) * 2005-06-16 2012-08-28 Nektar Therapeutics Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
US20120318701A1 (en) * 2006-07-21 2012-12-20 Nektar Therapeutics Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom
US20130225789A1 (en) * 2012-02-29 2013-08-29 Yi Sun Polyethylene Glycol Having Hetero Multiple Functional Groups
EP3279236A1 (fr) * 2015-03-31 2018-02-07 NOF Corporation Dérivé de polyéthylène glycol biodégradable ayant un lieur benzylidène acétal cyclique

Also Published As

Publication number Publication date
WO2020077289A2 (fr) 2020-04-16
AU2019358201A1 (en) 2021-05-20
CA3112834A1 (fr) 2020-04-16
US20210388161A1 (en) 2021-12-16
CN112839979A (zh) 2021-05-25
CN112839979B (zh) 2024-06-21
JP2022512627A (ja) 2022-02-07
MX2021004179A (es) 2021-09-08
EP3864068A2 (fr) 2021-08-18
KR20210077677A (ko) 2021-06-25
US11932726B2 (en) 2024-03-19

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