MX2021004179A - Metodo para preparar reactivos polimericos liberables. - Google Patents

Metodo para preparar reactivos polimericos liberables.

Info

Publication number
MX2021004179A
MX2021004179A MX2021004179A MX2021004179A MX2021004179A MX 2021004179 A MX2021004179 A MX 2021004179A MX 2021004179 A MX2021004179 A MX 2021004179A MX 2021004179 A MX2021004179 A MX 2021004179A MX 2021004179 A MX2021004179 A MX 2021004179A
Authority
MX
Mexico
Prior art keywords
polymeric reagents
fluorenyl
methods
based polymeric
prepared
Prior art date
Application number
MX2021004179A
Other languages
English (en)
Inventor
Sean M Culbertson
Samuel P Mcmanus
Antoni Kozlowski
Venkata Somu
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of MX2021004179A publication Critical patent/MX2021004179A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33396—Polymers modified by chemical after-treatment with organic compounds containing nitrogen having oxygen in addition to nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/333—Polymers modified by chemical after-treatment with organic compounds containing nitrogen
    • C08G65/33331—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group
    • C08G65/33337—Polymers modified by chemical after-treatment with organic compounds containing nitrogen containing imide group cyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/46—Post-polymerisation treatment, e.g. recovery, purification, drying

Abstract

La presente solicitud proporciona (entre otras cosas) metodos mejorados para preparar reactivos polimericos basados en fluorenilo, metodos para recuperar y purificar tales reactivos polimericos, metodos para reducir impurezas no deseadas en un reactivo polimerico basado en fluorenilo, reactivos polimericos basados en fluorenilo preparados mediante los metodos descritos en la presente, y conjugados preparados por reaccion con reactivos polimericos basados en fluorenilo preparados mediante los metodos descritos en la presente.
MX2021004179A 2018-10-11 2019-10-11 Metodo para preparar reactivos polimericos liberables. MX2021004179A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862744512P 2018-10-11 2018-10-11
PCT/US2019/055971 WO2020077289A2 (en) 2018-10-11 2019-10-11 Method of making releasable polymeric reagents

Publications (1)

Publication Number Publication Date
MX2021004179A true MX2021004179A (es) 2021-09-08

Family

ID=68425321

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021004179A MX2021004179A (es) 2018-10-11 2019-10-11 Metodo para preparar reactivos polimericos liberables.

Country Status (9)

Country Link
US (1) US11932726B2 (es)
EP (1) EP3864068A2 (es)
JP (1) JP2022512627A (es)
KR (1) KR20210077677A (es)
CN (1) CN112839979A (es)
AU (1) AU2019358201A1 (es)
CA (1) CA3112834A1 (es)
MX (1) MX2021004179A (es)
WO (1) WO2020077289A2 (es)

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5629384A (en) 1994-05-17 1997-05-13 Consiglio Nazionale Delle Ricerche Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
ATE424431T2 (de) * 1999-12-22 2009-03-15 Nektar Therapeutics Al Corp Verfahren zur herstellung von 1- benzotriazolcarbonatestern von wasserlöslichen polymeren
DK1656410T3 (da) 2003-07-22 2010-06-28 Nektar Therapeutics Fremgangsmåde til fremstillilng af funktionaliserede polymere fra polymeralkoholer
RS53968B1 (en) 2005-06-16 2015-08-31 Nektar Therapeutics CONJUGATES WHICH HAVE A COUPLING WHICH MAY BE DEGRADED AND POLYMER REAGENTS USED FOR THE PREPARATION OF SUCH CONJUGATES
ES2529258T3 (es) 2005-07-29 2015-02-18 Nektar Therapeutics Métodos para preparar reactivos poliméricos
EP2044150B1 (en) * 2006-07-21 2014-01-15 Nektar Therapeutics Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom
US20130225789A1 (en) 2012-02-29 2013-08-29 Yi Sun Polyethylene Glycol Having Hetero Multiple Functional Groups
JP6784932B2 (ja) 2015-03-31 2020-11-18 日油株式会社 生体機能性分子または薬物キャリアの化学修飾用生分解性ポリエチレングリコール誘導体

Also Published As

Publication number Publication date
CN112839979A (zh) 2021-05-25
AU2019358201A1 (en) 2021-05-20
JP2022512627A (ja) 2022-02-07
CA3112834A1 (en) 2020-04-16
US11932726B2 (en) 2024-03-19
WO2020077289A3 (en) 2020-06-11
US20210388161A1 (en) 2021-12-16
KR20210077677A (ko) 2021-06-25
EP3864068A2 (en) 2021-08-18
WO2020077289A2 (en) 2020-04-16

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