WO2020075387A1 - 電気治療用具 - Google Patents

電気治療用具 Download PDF

Info

Publication number
WO2020075387A1
WO2020075387A1 PCT/JP2019/032095 JP2019032095W WO2020075387A1 WO 2020075387 A1 WO2020075387 A1 WO 2020075387A1 JP 2019032095 W JP2019032095 W JP 2019032095W WO 2020075387 A1 WO2020075387 A1 WO 2020075387A1
Authority
WO
WIPO (PCT)
Prior art keywords
lumen
needle
distal end
electrode
needle tube
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2019/032095
Other languages
English (en)
French (fr)
Japanese (ja)
Inventor
岸田　学
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kaneka Corp
Original Assignee
Kaneka Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corp filed Critical Kaneka Corp
Priority to JP2020550005A priority Critical patent/JP7286670B2/ja
Priority to US17/279,790 priority patent/US12172009B2/en
Publication of WO2020075387A1 publication Critical patent/WO2020075387A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0502—Skin piercing electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

Definitions

  • the present invention relates to an electrotherapy device. More specifically, the present invention relates to an electrotherapy device including an electrode needle that applies high frequency to living tissue and a needle tube that injects a drug or the like into living tissue.
  • the electroporation method is known as a method in which a drug or the like is easily injected into a biological tissue such as cells by injecting the drug or the like while applying an electric field to a bipolar electrode.
  • Patent Document 1 proposes an electroporation device having a plurality of electrodes as an electrotherapy tool used in such a procedure.
  • the electroporation device proposed in Patent Document 1 is housed so as to be capable of projecting and retracting from the tip end portion of the guide cylinder, and includes a pair of electrodes for applying the DC pulse generated by the pulse applying means.
  • Patent Document 1 describes that a drug, a gene, or the like is locally distributed in a malignant tumor or the like by local injection, arterial injection, or intravenous injection, and then a DC pulse is applied.
  • an electrode is arranged on an easily accessible site such as a body surface, and a drug or the like can be injected into the body surface before or while applying an electric field to a desired region.
  • a drug or the like can be injected into the body surface before or while applying an electric field to a desired region.
  • a desired region could not be injected deep into the body.
  • the present invention has been made in view of the above circumstances, and its purpose is to be suitable for use in an electroporation method, and in particular, an electrotherapy device capable of injecting a drug or the like into a deep part of the body. To provide.
  • the electrotherapy device has the following configuration in order to solve the above problems. That is, an outer shaft having a lumen and extending in the perspective direction, an inner shaft arranged in the lumen of the outer shaft, a needle tube fixed to the inner shaft, and fixed to the inner shaft.
  • a linear conductor including an electrode needle and a conductive wire arranged at a proximal portion of the electrode needle, wherein the needle tube and the electrode needle project from a distal portion of the outer shaft. It is a immersive electrotherapy device.
  • a needle tube and an electrode needle are fixed to an inner shaft arranged in the inner cavity of the outer shaft, and the needle tube and the electrode needle project from the distal portion of the outer shaft. Since it is possible, a drug or the like can be injected from the needle tube to a deep part in the body, and an electric field can be applied to a desired region from the electrode needle.
  • FIG. 1 is a cross-sectional view showing a configuration example of a distal portion of an electrotherapy device according to the present invention, showing a state in which a needle tube and an electrode needle are not projected from a distal portion of an outer shaft.
  • FIG. 2 is a cross-sectional view of the distal portion of the electrotherapy device shown in FIG. 1, showing a state in which the needle tube and the electrode needle are projected from the distal portion of the outer shaft.
  • 3 is a perspective view of a distal portion of the electrotherapy device shown in FIG.
  • FIG. 4 is a cross-sectional view showing another configuration example of the distal portion of the electrotherapy device according to the present invention, showing a state in which the needle tube and the electrode needle are projected from the distal portion of the outer shaft.
  • 5A is a view taken along the arrow line III-III in FIG. 4
  • FIG. 5B is a view taken along the line IV-IV in FIG.
  • the electrotherapy device has an outer shaft having a lumen and extending in a perspective direction, an inner shaft arranged in the lumen of the outer shaft, a needle tube fixed to the inner shaft, and An electrode needle fixed to an inner shaft, and a linear conductor including a conductive wire arranged at a proximal portion of the electrode needle, wherein the needle tube and the electrode needle are the outer side. It is characterized in that it can be projected and retracted from the distal portion of the shaft.
  • a drug or the like can be injected from the needle tube to a deep inside of the body, and the electrode An electric field can be applied from the needle to the desired area.
  • the electrotherapeutic device according to the present invention will be specifically described with reference to the drawings, but the present invention is not limited to the illustrated examples, and changes are made within a range that can be adapted to the gist of the above and the following. It is also possible to carry out the present invention, and all of them are included in the technical scope of the present invention.
  • the operator's hand side of the electrotherapy device is the proximal side, and the side opposite to the hand side is the distal side.
  • FIG 1 and 2 are cross-sectional views schematically showing an example of an embodiment of an electrotherapy device 100 according to the present invention, showing a distal portion of the electrotherapy device.
  • the inner shaft 2 is arranged in the inner cavity of the outer shaft 1 having the inner cavity and extending in the perspective direction.
  • the needle tube 3 and the electrode needle 4 are fixed to the distal portion of the inner shaft 2.
  • the needle tube 3 and / or the electrode needle 4 may be directly fixed to the inner shaft 2 or indirectly fixed to the inner shaft 2.
  • the fixing form is not particularly limited, and may be fixed using a fixing member or an adhesive, or may be fixed by heat fusion or press fitting.
  • the distal end of the inner shaft 2 may be in a state in which a portion other than the needle tube 3 and the electrode needle 4 of the linear conductor is blocked. As a result, it is possible to prevent body fluid and the like from entering the inside shaft 2.
  • a lumen (through passage) 11 is formed in the inner shaft 2, and the lumen 11 is connected to the proximal end of the needle tube 3.
  • a drug or the like can be injected from the proximal side of the electrotherapy device 100 into the deep part of the living body through the lumen 11 and the needle tube 3.
  • a conductive wire 5 is arranged at the proximal portion of the electrode needle 4 fixed to the inner shaft 2. In FIGS. 1 and 2, the proximal end of the electrode needle 4 and the distal end of the conductive wire 5 are connected.
  • FIG. 1 shows a state in which the needle tube 3 and the electrode needle 4 are not projected from the distal portion of the outer shaft 1
  • FIG. 2 is a view in which the needle tube 3 and the electrode needle 4 are projected from the distal portion of the outer shaft 1. Shows the closed state.
  • a perspective view of the distal portion of the electrotherapy device 100 shown in FIG. 2 is shown in FIG.
  • the needle tubes 3 and the set of electrode needles 4 are not arranged in a line, but in the cross-sectional views shown in FIGS. 1 and 2, the needle tubes 3 and the set of electrodes are shown for convenience of illustration.
  • the needles 4 are shown side by side in the same cross section.
  • the outer shaft 1 and the inner shaft 2 are not fixed to each other and are relatively movable in the perspective direction. Therefore, by pulling the outer shaft 1 proximally, pushing the inner shaft 2 distally, or pulling the outer shaft 1 proximally and pushing the inner shaft 2 distally, the needle tube 3 and The electrode needle 4 can be projected and retracted from the distal portion of the outer shaft 1.
  • the electrotherapy device 100 transfers the needle tube 3 and the electrode needle 4 from the distal portion of the outer shaft 1 to the treatment site without protruding, and at the treatment site, as shown in FIG. Then, the needle tube 3 and the electrode needle 4 may be projected from the distal portion of the outer shaft 1.
  • the electrotherapy device 100 is delivered from the body surface to a treatment site through a body cavity such as a blood vessel or a digestive tract.
  • the electrotherapy device 100 may be directly inserted into a body cavity, or may be used with another device such as an endoscope.
  • a coating may be applied to the surface of the outer shaft 1 to facilitate passage through the body cavity or the lumen of the endoscope.
  • the surface of the inner shaft 2 may be coated so that the movement in the outer shaft 1 is smooth.
  • a drug or the like may be injected into the body from the needle tube 3, and then an electric field may be applied from the electrode needle 4, or the drug or the like may be injected into the body from the needle tube 3 while applying an electric field from the electrode needle 4.
  • An electric field may be applied after injecting a drug or the like, and by using the electrotherapeutic device 100 of the present invention, the needle tube 3 can be punctured into a deep part of the body, and thus the drug or the like can be injected into a deep part of the body.
  • the positions of the distal end of the electrode needle 4 and the distal end of the needle tube 3 in the perspective direction may be the same, but the distal end of the electrode needle 4 is more distal than the distal end of the needle tube 3. Is preferred. Thereby, the electrode needle 4 can be inserted deeper into the target site in the body than the needle tube 3. When the medicine injected from the needle tube 3 moves to the deeper side in the body than the distal end of the needle tube 3, the electric field generated by the electrode needle 4 can be applied more appropriately to the medicine.
  • FIG. 1 to 3 show the structure in which the lumen 11 formed in the inner shaft 2 and the needle tube 3 are connected, for example, as shown in FIG. 4, a tube is provided at the proximal end of the needle tube 3.
  • the body 6 may be connected.
  • the proximal end of the inner shaft 2 and the proximal end of the tube body 6 are preferably arranged in a handle connected to the proximal side of the inner shaft 2. Further, by connecting the proximal end of the inner shaft 2 and the proximal end of the tube body 6 to the drug injection port provided in the handle, injection of a drug or the like becomes easier.
  • the tube body 6 and the conductive wire 5 of the linear conductor can be arranged in the lumen.
  • the conductive wire 5 By fixing the conductive wire 5 to the inner wall surface of the inner shaft 2 or the tube body 6, it is possible to prevent the conductive wire 5 from being entangled when the electrotherapy device 100 is operated.
  • the above linear conductor includes an electrode needle 4 and a conductive wire 5.
  • the electrode needle 4 and the conductive wire 5 may be composed of one member, or may be composed of a plurality of members such as a needle and a conductive wire.
  • a portion of the inner shaft 2 distal to the distal end can be the electrode needle 4.
  • the proximal part of the linear conductor or the proximal part of the conductive wire 5 may be connected to a power source to generate an electric field between the electrode needles 4.
  • the conductive wire 5 may be connected to the proximal portion of the electrode needle 4, and the conductive wire may not be connected to the proximal portion of the needle tube 3. Thereby, the insulation of the needle tube 3 can be improved.
  • An insulating layer may be arranged outside the needle tube 3 in order to enhance the insulation of the needle tube 3.
  • an insulating layer may be arranged outside the conductive wire 5 in order to enhance the insulating property of the conductive wire 5.
  • the insulating layer may be formed using a known insulating material.
  • the distal end of the electrode needle 4 may or may not be punctured in a living tissue.
  • the electric field can be applied to the deep part of the living body by piercing the living tissue with the more proximal side of the electrode needle 4.
  • the electrotherapy device 100 of the present invention has at least two of the electrode needles 4, and the distance between the two electrode needles 4 becomes shorter toward the distal end of the electrode needle 4. It is preferable.
  • the electrode needle 4 is configured to be able to puncture a living tissue
  • the distal end portion of the electrode needle 4 is formed into a V-shape that narrows toward the distal side, so that it is easy to puncture a treatment site. Become.
  • the conductive wire 5 may be fixed to the inner shaft 2. By fixing the conductive wire 5 to the inner shaft 2, entanglement of the conductive wire 5 can be prevented.
  • the electrode needle 4 and the conductive wire 5 may be made of different materials or may be made of the same material.
  • the electrode needle 4 and the conductive wire 5 may be integrated or separated, and may be indirectly connected.
  • Examples of the material forming the electrode needle 4 and the conductive wire 5 include stainless steel, tungsten, copper, and conductive alloys.
  • the surface of the electrode needle 4 and / or the conductive wire 5 may be plated, and examples of the type of plating include gold plating and platinum plating.
  • the linear conductor including the electrode needle 4 and the conductive wire 5 may have a straight shape without a bent portion, or may have a flare shape in which the distal end portion of the electrode needle 4 spreads outward.
  • a first bent portion 21 which is convex toward the inside of the electric treatment instrument 100, and a distal side of the first bent portion 21 and an outside of the electric treatment instrument 100.
  • the second bent portion 22 that is convex toward.
  • the distal end of the needle tube 3 is located distally of the first bent portion 21. It is preferable. By arranging the needle tube 3 in this way, it becomes easy to puncture the needle tube 3 into a deep part of a living body.
  • the inner shaft 2 has a first lumen, a second lumen, and a third lumen in its inner cavity, and the proximal end of the needle tube 3 is arranged in the inner lumen of the first lumen.
  • the conductive wires 5 may be arranged in the lumens of the second lumen and the third lumen, respectively. Thereby, the insulating property of the conductive wire 5 of the linear conductor can be further enhanced.
  • the electric field applied to the target site by the electrode needle 4 may be of a bipolar type or a monopolar type. When the bipolar type is used, the insulating property can be further improved by dividing the lumen in which the conductive wire 5 of the linear conductor is arranged by the pole.
  • the inner shaft 2 can surely differ in the arrangement location of the linear conductor and the needle tube 3 by disposing a plurality of, for example, three lumens in the inner cavity thereof, so that in the electrotherapy device 100. The contact between the electricity and the liquid can be suppressed.
  • a tube body 6 may be connected to the proximal end portion of the needle tube 3, or the needle tube 3 is directly fixed to the distal end of the first lumen, so that a drug or the like is It may pass directly through the first lumen.
  • the inner cavity of the inner shaft 2 in the configuration in which the tube body 6 is connected will be described with reference to FIG.
  • FIG. 5A is an arrow view of the electrotherapy device 100 shown in FIG. 4 at the position III-III.
  • the inner shaft 2 has a first lumen 31, a second lumen 32, and a third lumen 33 in its inner cavity.
  • the tube body 6 is arranged in the first lumen 31 at the position III-III shown in FIG. 4, and the tube body 6 and the first lumen 31 are not fixed. Further, the conductive wire 5 is arranged in the second lumen 32 and the third lumen 33 at the position III-III shown in FIG. 4, and the conductive wire 5 and the second lumen 32 and the third lumen 33 are not connected to each other. It is fixed.
  • FIG. 5B shows a cross-sectional view of the electrotherapy device 100 shown in FIG. 4 at the distal end of the inner shaft 2, that is, an arrow view at the IV-IV position.
  • the needle tube 3 is arranged in the first lumen 31, and the needle tube 3 and the first lumen 31 are fixed.
  • the electrode needle 4 is arranged in the second lumen 32 and the third lumen 33 at the IV-IV position shown in FIG. 4, and the electrode needle 4 and the second lumen 32 and the third lumen 33 are fixed. ing.
  • the line connecting the center of the second lumen 32 and the center of the third lumen 33 and the center of the first lumen 31 In a cross section perpendicular to the perspective direction on the 3 cm proximal side from the distal end of the inner shaft 2, the line connecting the center of the second lumen 32 and the center of the third lumen 33 and the center of the first lumen 31.
  • the linear conductor disposed in the second lumen 32 and the linear conductor disposed in the third lumen 33 in a cross section perpendicular to the perspective direction at the distal end of the needle tube 3 than the distance. It is preferable that the distance between the line connecting to and the distal end of the needle tube 3 is shorter. With this configuration, a chemical solution or the like can be injected between the electrode needles 4.
  • the pulse parameters applied to the electrode needle 4 differ depending on the treatment conditions.
  • the magnetic field strength is 1 to 2000 V / cm
  • the pulse length is 0.1 to 10.0 mm
  • the pulse number is 2 to 20
  • the pulse frequency is 1 to It can be 5 Hz.
  • An X-ray opaque marker is placed at the distal end of the outer shaft 1 and / or the distal end of the inner shaft 2 to confirm the positions of the needle tube 3 and the electrode needle 4 under X-ray fluoroscopy.
  • the radiopaque marker it is possible to confirm the position of the distal end portion of the outer shaft 1 and / or the distal end portion of the inner shaft 2 in which the radiopaque marker is placed under the radiopaque condition.
  • the puncture depth of the needle tube 3 can be adjusted.
  • the shape of the X-ray opaque marker is preferably a tubular shape.
  • the tubular shape include a cylindrical shape, a polygonal tubular shape, a C-shaped cross-section with a slit in the tube, and a coil shape in which a wire is wound. Is mentioned.
  • the shape of the radiopaque marker is more preferably cylindrical. With the X-ray opaque marker thus configured, it becomes easy to confirm the X-ray opaque marker by X-ray transmission.
  • the shapes of the radiopaque markers arranged at the distal end of the outer shaft 1 and the distal end of the inner shaft 2 may be the same or different.
  • an X-ray opaque substance such as lead, barium, iodine, tungsten, gold, platinum, iridium, stainless steel, titanium, and cobalt chromium alloy can be used.
  • platinum is more preferable.
  • the visibility of the radiopaque marker is made the same by the radiolucency. Since it can be set to a degree, it becomes easy to grasp the positions of the tip portions of the needle tube 3, the electrode needle 4, the outer shaft 1, and the like.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Biophysics (AREA)
  • Electrotherapy Devices (AREA)
PCT/JP2019/032095 2018-10-12 2019-08-16 電気治療用具 Ceased WO2020075387A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2020550005A JP7286670B2 (ja) 2018-10-12 2019-08-16 電気治療用具
US17/279,790 US12172009B2 (en) 2018-10-12 2019-08-16 Electrotherapy device

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2018193126 2018-10-12
JP2018-193126 2018-10-12

Publications (1)

Publication Number Publication Date
WO2020075387A1 true WO2020075387A1 (ja) 2020-04-16

Family

ID=70164126

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2019/032095 Ceased WO2020075387A1 (ja) 2018-10-12 2019-08-16 電気治療用具

Country Status (3)

Country Link
US (1) US12172009B2 (https=)
JP (1) JP7286670B2 (https=)
WO (1) WO2020075387A1 (https=)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004041434A (ja) * 2002-07-11 2004-02-12 Kiyohito Ishida エレクトロポレーション装置
JP2007215863A (ja) * 2006-02-17 2007-08-30 Terumo Corp 医療用具
JP2012515018A (ja) * 2009-01-12 2012-07-05 エシコン・エンド−サージェリィ・インコーポレイテッド 電気的アブレーション装置
JP2016500329A (ja) * 2012-12-21 2016-01-12 ユニバーシティ・カレッジ・コークーナショナル・ユニバーシティ・オブ・アイルランド，コーク 吸引ヘッドおよび針電極を備えた胸腔鏡電気穿孔デバイス

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004041434A (ja) * 2002-07-11 2004-02-12 Kiyohito Ishida エレクトロポレーション装置
JP2007215863A (ja) * 2006-02-17 2007-08-30 Terumo Corp 医療用具
JP2012515018A (ja) * 2009-01-12 2012-07-05 エシコン・エンド−サージェリィ・インコーポレイテッド 電気的アブレーション装置
JP2016500329A (ja) * 2012-12-21 2016-01-12 ユニバーシティ・カレッジ・コークーナショナル・ユニバーシティ・オブ・アイルランド，コーク 吸引ヘッドおよび針電極を備えた胸腔鏡電気穿孔デバイス

Also Published As

Publication number Publication date
JPWO2020075387A1 (ja) 2021-09-02
US20210330966A1 (en) 2021-10-28
US12172009B2 (en) 2024-12-24
JP7286670B2 (ja) 2023-06-05

Similar Documents

Publication Publication Date Title
US9877781B2 (en) Electrode catheter device with indifferent electrode for direct current tissue therapies
JP5654181B2 (ja) 高周波ナイフ
JP6600632B2 (ja) 身体の一部への電界治療の適用
CN119012978A (zh) 脉冲电场消融装置及方法
US20050020965A1 (en) Devices and methods for delivering agents to tissue region while preventing leakage
EP2211982B1 (en) An electroporation device for improved electrical field control
US20090312617A1 (en) Needle injection catheter
US20100298761A1 (en) Electroporation device with improved tip and electrode support
US9750564B2 (en) Flexible catheter for high-frequency therapy of biological tissue and method of using same
US20070282325A1 (en) Composite material braided insulator
KR101370048B1 (ko) 신경차단용 카테터
US20240216057A1 (en) Pulsed field ablation device and method
KR20160103351A (ko) 카테터 및 이를 포함하는 신경차단 장치
CN116457046A (zh) 穿刺设备
JP2016137020A (ja) 電極カテーテル、電極カテーテルの製造方法
JP7286670B2 (ja) 電気治療用具
CN110051390A (zh) 一种疼痛治疗用电刺激射频外鞘导管
CN110338903A (zh) 一种用于引导电极的穿刺针及电极输送装置
JP7426263B2 (ja) 穿刺針、針カテーテル、及び、カテーテルシステム
WO2020170582A1 (ja) 薬剤注入カテーテル
US20250010066A1 (en) Adjustable needle electrodes for medical procedures and associated systems and methods
JP2025006085A (ja) 電極カテーテル

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19871267

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2020550005

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 19871267

Country of ref document: EP

Kind code of ref document: A1