JP2012515018A - 電気的アブレーション装置 - Google Patents
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Abstract
Description
(1) 第1及び第2の電極であって、各電極が、エネルギー源に結合するよう構成された第1の末端部と、組織処置領域に結合するよう構成された第2の末端部とを含む、第1及び第2の電極と、
前記第1及び第2の電極に結合されたエネルギー源であって、前記第1及び第2の電極の少なくとも一方を介して、不可逆的エレクトロポレーションによる細胞壊死を誘導するのに十分な第1の一連の電気パルスと、熱的加熱により細胞壊死を誘導するのに十分な第2の一連の電気パルスとを供給するよう構成されている、エネルギー源と、を備える電気的アブレーション機器であって、
前記第1の一連の電気パルスは第1の振幅、第1のパルス長、及び第1の周波数により特徴付けられ、
前記第2の一連の電気パルスは第2の振幅、第2のパルス長、及び第2の周波数により特徴付けられる、電気的アブレーション機器。
(2) 前記第1の振幅が約1000VDCであり、前記第1のパルス長が約10μs〜約15μsであり、前記第1の周波数が約10Hzであり;前記第2の振幅が約500VDCであり、前記第2のパルス長が約10ms〜約15msであり、前記第2の周波数が約10Hzである、実施態様1に記載の電気的アブレーション機器。
(3) 前記第1の振幅が約±100〜約±3000VDCの範囲内から選択され、前記第1のパルス長が約1μs〜約100msの範囲内から選択され、前記第1の周期が約1Hz〜約10000Hzの範囲内から選択される、実施態様1に記載の電気的アブレーション機器。
(4) 前記第1の一連の電気パルスが約20〜約40のパルスを含み、前記第2の一連の電気パルスが少なくとも1つのパルスを含む、実施態様1に記載の電気的アブレーション機器。
(5) 前記第1及び第2の電極が、約0.5mm〜約1.5mmの範囲内の直径をそれぞれが有する針電極であり、約5.0mm〜約10.0mmの距離により分離される、実施態様1に記載の電気的アブレーション機器。
(6) 前記第1の一連の電気パルスが、前記第1及び第2の電極の両方を包囲する範囲内で、組織の第1部分内に不可逆的エレクトロポレーションにより誘導される第1の壊死部を形成するのに十分であり、前記第2の一連の電気パルスが、電極と組織との境界面の近傍の範囲内で、組織の第2部分内に熱的加熱により誘導される第2の壊死部を形成するのに十分である、実施態様5に記載の電気的アブレーション機器。
(7) 前記第1の一連の電気パルスが、基底細胞癌組織をアブレーションするのに十分である、実施態様6に記載の電気的アブレーション機器。
(8) 前記第1の一連の電気パルスが、前立腺癌組織をアブレーションするのに十分である、実施態様6に記載の電気的アブレーション機器。
(9) 前記第1及び第2の電極がリング電極である、実施態様1に記載の電気的アブレーション機器。
(10) 前記第1の一連の電気パルスが、身体管腔内で、組織の第1部分内に不可逆的エレクトロポレーションにより誘導される第1の壊死部を形成するのに十分であり、前記第2の一連の電気パルスが、熱的加熱により前記身体管腔を密封することによって前記身体管腔内に第2の壊死部を形成するのに十分である、実施態様9に記載の電気的アブレーション機器。
(12) 前記第1の電極が複数の電極を含む、実施態様1に記載の電気的アブレーション機器。
(13) 前記第2の電極が複数の電極を含む、実施態様1に記載の電気的アブレーション機器。
(14) 遠位端から近位端へ延びる細長い管状本体と、
膨張可能な導電性エラストマー電極と、
非導電性カテーテルと、
当該膨張可能な導電性エラストマー電極に結合されたエネルギー源であって、当該膨張可能な導電性エラストマー電極を介して不可逆的エレクトロポレーションにより細胞壊死を誘導するのに十分な第1の一連の電気パルスを供給するよう構成されている、エネルギー源と、を備える電気的アブレーション機器であって、
前記第1の一連の電気パルスは第1の振幅、第1のパルス長及び第1の周波数により特徴付けられる、電気的アブレーション機器。
(15) 前記膨張可能な導電性エラストマー電極が、
当該膨張可能な導電性エラストマー電極に結合された導電性端子と、
一方の末端部が前記導電性端子に結合され、他方の末端部が前記エネルギーの第1の端子に結合された第1の導電性ワイヤと、を備える、実施態様14に記載の電気的アブレーション機器。
(16) リターン電極と、
一方の末端部が当該リターン電極に結合され、他方の末端部が前記エネルギー源の第2の端子に結合された第2の導電性ワイヤと、を備える、実施態様15に記載の電気的アブレーション機器。
(17) 前記膨張可能な導電性エラストマー電極が、
エラストマーマトリックスと、
当該エラストマーマトリックス中に浸潤された導電性金属フィラー材料とを含み、かつ
当該エラストマーマトリックスの弾性特性と、前記金属フィラー材料の当該導電性特性とを有する、実施態様14に記載の電気的アブレーション機器。
(18) 前記第1の振幅が約±100〜約±3000VDCの範囲内から選択され、前記第1のパルス長が約1μs〜約100msの範囲内から選択され、前記第1の周期が約1Hz〜約10000Hzの範囲内から選択される、実施態様14に記載の電気的アブレーション機器。
(19) 遠位端に圧縮スポンジを有するカテーテルと、
当該カテーテル上に摺動可能に配置されて、前記スポンジが拡張される準備が整う迄、前記スポンジを収容するスリーブと、
当該カテーテルを通して前記スポンジ内に挿入された少なくとも1つの電極と、
前記少なくとも1つの電極に結合されたエネルギー源であって、前記少なくとも1つの電極を介して不可逆的エレクトロポレーションにより細胞壊死を誘導するのに十分な第1の一連の電気パルスを供給するよう構成されている、エネルギー源と、を備える電気的アブレーション機器であって、
前記第1の一連の電気パルスは第1の振幅、第1のパルス長及び第1の周波数により特徴付けられる、電気的アブレーション機器。
(20) 1つ又は2つ以上の大表面積電極を備える、実施態様19に記載の電気的アブレーション機器。
(22) 前記第1の一連のパルスが、望ましくない組織の塊の除去後に固形組織内に形成された空洞内の望ましくない残留組織をアブレーションする不可逆的エレクトロポレーションを形成するのに十分である、実施態様21に記載の電気的アブレーション機器。
(23) 複数の電極が、前記カテーテルを通して前記スポンジ内に挿入される、実施態様19に記載の電気的アブレーション機器。
Claims (10)
- 第1及び第2の電極であって、各電極が、エネルギー源に結合するよう構成された第1の末端部と、組織処置領域に結合するよう構成された第2の末端部とを含む、第1及び第2の電極と、
前記第1及び第2の電極に結合されたエネルギー源であって、前記第1及び第2の電極の少なくとも一方を介して、不可逆的エレクトロポレーションによる細胞壊死を誘導するのに十分な第1の一連の電気パルスと、熱的加熱により細胞壊死を誘導するのに十分な第2の一連の電気パルスとを供給するよう構成されている、エネルギー源と、を備える電気的アブレーション機器であって、
前記第1の一連の電気パルスは第1の振幅、第1のパルス長、及び第1の周波数により特徴付けられ、
前記第2の一連の電気パルスは第2の振幅、第2のパルス長、及び第2の周波数により特徴付けられる、電気的アブレーション機器。 - 前記第1の振幅が約1000VDCであり、前記第1のパルス長が約10μs〜約15μsであり、前記第1の周波数が約10Hzであり;前記第2の振幅が約500VDCであり、前記第2のパルス長が約10ms〜約15msであり、前記第2の周波数が約10Hzである、請求項1に記載の電気的アブレーション機器。
- 前記第1の振幅が約±100〜約±3000VDCの範囲内から選択され、前記第1のパルス長が約1μs〜約100msの範囲内から選択され、前記第1の周期が約1Hz〜約10000Hzの範囲内から選択される、請求項1に記載の電気的アブレーション機器。
- 前記第1の一連の電気パルスが約20〜約40のパルスを含み、前記第2の一連の電気パルスが少なくとも1つのパルスを含む、請求項1に記載の電気的アブレーション機器。
- 前記第1及び第2の電極が、約0.5mm〜約1.5mmの範囲内の直径をそれぞれが有する針電極であり、約5.0mm〜約10.0mmの距離により分離される、請求項1に記載の電気的アブレーション機器。
- 前記第1の一連の電気パルスが、前記第1及び第2の電極の両方を包囲する範囲内で、組織の第1部分内に不可逆的エレクトロポレーションにより誘導される第1の壊死部を形成するのに十分であり、前記第2の一連の電気パルスが、電極と組織との境界面の近傍の範囲内で、組織の第2部分内に熱的加熱により誘導される第2の壊死部を形成するのに十分である、請求項5に記載の電気的アブレーション機器。
- 前記第1の一連の電気パルスが、基底細胞癌組織をアブレーションするのに十分である、請求項6に記載の電気的アブレーション機器。
- 前記第1の一連の電気パルスが、前立腺癌組織をアブレーションするのに十分である、請求項6に記載の電気的アブレーション機器。
- 前記第1及び第2の電極がリング電極である、請求項1に記載の電気的アブレーション機器。
- 前記第1の一連の電気パルスが、身体管腔内で、組織の第1部分内に不可逆的エレクトロポレーションにより誘導される第1の壊死部を形成するのに十分であり、前記第2の一連の電気パルスが、熱的加熱により前記身体管腔を密封することによって前記身体管腔内に第2の壊死部を形成するのに十分である、請求項9に記載の電気的アブレーション機器。
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Application Number | Priority Date | Filing Date | Title |
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US12/352,375 US8361066B2 (en) | 2009-01-12 | 2009-01-12 | Electrical ablation devices |
US12/352,375 | 2009-01-12 | ||
PCT/US2010/020465 WO2010080974A1 (en) | 2009-01-12 | 2010-01-08 | Electrical ablation devices |
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JP2012515018A true JP2012515018A (ja) | 2012-07-05 |
JP5680550B2 JP5680550B2 (ja) | 2015-03-04 |
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US (4) | US8361066B2 (ja) |
EP (2) | EP2396074B1 (ja) |
JP (1) | JP5680550B2 (ja) |
CA (1) | CA2749362C (ja) |
WO (1) | WO2010080974A1 (ja) |
Cited By (46)
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JP2014502195A (ja) * | 2010-11-19 | 2014-01-30 | セント・ジュード・メディカル・エイトリアル・フィブリレーション・ディヴィジョン・インコーポレーテッド | 直流組織治療のための不関電極を有する電極カテーテル機器 |
JP2014514025A (ja) * | 2011-03-08 | 2014-06-19 | コーエン,トッド,ジェイ. | 安全機能を有するアブレーションカテーテルシステム |
WO2015023075A1 (ko) * | 2013-08-12 | 2015-02-19 | 재단법인 아산사회복지재단 | 카테터가 구비된 고주파 소작장치 |
JP2015524732A (ja) * | 2012-08-15 | 2015-08-27 | エシコン・エンド−サージェリィ・インコーポレイテッドEthicon Endo−Surgery,Inc. | 電気手術装置及び方法 |
JP2017518805A (ja) * | 2014-05-12 | 2017-07-13 | バージニア テック インテレクチュアル プロパティース インコーポレイテッド | パルス電界を使用した細胞の細胞内効果の選択的調節 |
US9883910B2 (en) | 2011-03-17 | 2018-02-06 | Eticon Endo-Surgery, Inc. | Hand held surgical device for manipulating an internal magnet assembly within a patient |
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2015
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US20120330306A1 (en) | 2012-12-27 |
EP2396074B1 (en) | 2015-08-26 |
US20180360535A1 (en) | 2018-12-20 |
US9011431B2 (en) | 2015-04-21 |
CA2749362C (en) | 2018-04-17 |
US8361066B2 (en) | 2013-01-29 |
WO2010080974A1 (en) | 2010-07-15 |
US20100179530A1 (en) | 2010-07-15 |
US10004558B2 (en) | 2018-06-26 |
JP5680550B2 (ja) | 2015-03-04 |
EP2957248A1 (en) | 2015-12-23 |
EP2396074A1 (en) | 2011-12-21 |
US20150265342A1 (en) | 2015-09-24 |
CA2749362A1 (en) | 2010-07-15 |
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