WO2020054033A1 - オートサンプラ用のプレートチェンジャ - Google Patents
オートサンプラ用のプレートチェンジャ Download PDFInfo
- Publication number
- WO2020054033A1 WO2020054033A1 PCT/JP2018/034027 JP2018034027W WO2020054033A1 WO 2020054033 A1 WO2020054033 A1 WO 2020054033A1 JP 2018034027 W JP2018034027 W JP 2018034027W WO 2020054033 A1 WO2020054033 A1 WO 2020054033A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- plate
- sample
- window
- stopper
- installation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0418—Plate elements with several rows of samples
- G01N2035/0425—Stacks, magazines or elevators for plates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/24—Automatic injection systems
Definitions
- the present invention is configured to take out a plate storage in which a plurality of sample plates holding samples to be analyzed by an analyzer such as a liquid chromatograph are installed, and to take out any sample plate stored in the plate storage.
- the present invention relates to a plate changer having a transport mechanism.
- an autosampler may be used to inject a plurality of samples into the analysis channel of the liquid chromatograph.
- a sample plate holding a plurality of sample vials and the sample itself is set at a predetermined position, and the sample held on the sample plate is automatically collected and analyzed by a liquid chromatograph. It is configured to be injected into the road (see Patent Document 1).
- the plate changer includes a plate storage for storing a plurality of sample plates, and a transport mechanism for transporting the sample plates stored in the plate storage.
- the transport mechanism takes out the sample plate from the plate storage and installs it in the autosampler, or stores the sample plate installed in the autosampler in the plate storage.
- the user only has to store a plurality of sample plates holding the samples to be analyzed in the plate storage of the plate changer.
- the sample plates are sequentially transported to the autosampler by the transport mechanism and installed, and the analysis of each sample is automatically performed sequentially.
- a user inserts a sample plate from a window (installation window) on the front side of the plate storage and installs the sample plate on a plate mounting table in the plate storage. At this time, the user may push the sample plate too far into the plate storage and drop it from the plate installation table. In order to prevent such a situation, it is conceivable to provide a stopper for preventing the sample plate from dropping on the rear side of the plate storage.
- a stopper for preventing the sample plate from dropping on the rear side of the plate storage.
- the transport mechanism takes out the sample plate from the plate storage, the transport mechanism and the sample plate interfere with the stopper, which hinders the removal of the sample plate by the transport mechanism.
- an object of the present invention is to prevent the sample plate from dropping when the sample plate is inserted into the plate storage, without hindering removal of the sample plate from the plate storage by the transport mechanism. It is.
- the plate changer for an autosampler includes a plate storage and a transport mechanism.
- the plate storage has a plate installation table for installing a sample plate therein, an installation window for inserting the sample plate in one direction in a horizontal plane and installing the sample plate on the plate installation table, and
- the installation window portion is provided with a transport window portion provided on the opposite side of the plate installation table to take out the sample plate installed on the plate installation table in the one direction.
- the transport mechanism has a gripper for gripping a sample plate, and grips and transports the sample plate installed on the plate mounting table with the gripper.
- the plate storage is configured such that when the sample plate inserted from the installation window reaches a predetermined position on the plate installation table in the one direction, an end surface of the sample plate on the side of the transport window.
- the transport window portion has a plate stopper that is arranged at an interference position in contact with and stops the sample plate, and the plate stopper is configured such that the sample plate on the plate mounting table is moved from the transport window portion by the grip portion. It is configured to be arranged at a non-interfering position that does not interfere with the grip portion and the sample plate when being taken out.
- the plate stopper includes a vertical bar extending in a vertical direction, and a rotating plate rotatable in a horizontal plane while holding one end of the vertical bar.
- the vertical rod is configured to move between the interference position and the non-interference position by rotating in the inside.
- the plate stopper may include two rotating plates, and the rotating plates may respectively hold an upper end and a lower end of the vertical bar.
- the plate changer according to the present invention may include an opening / closing door for opening and closing the installation window.
- the opening and closing door is opened, and thereafter, the opening and closing door is closed. That is, when the sample plate on the plate mounting table is taken out by the transport mechanism, the opening / closing door is closed. Therefore, the vertical bar of the plate stopper is arranged at the interference position when the door is open, and is arranged at the non-interference position when the door is closed. preferable. Then, the vertical bar of the plate stopper is arranged at the non-interfering position when the sample plate on the plate mounting table is taken out by the transport mechanism, so that the vertical bar is placed on the sample plate by the transport mechanism. It does not disturb the removal operation.
- a mechanism for interlocking the plate stopper with the opening and closing operation of the opening and closing door includes a shaft extending in the one direction and moving to the transport window side in conjunction with an operation when the opening and closing door is closed.
- the shaft moves toward the transfer window, and presses a part of the rotating plate of the plate stopper to rotate the rotating plate, thereby causing the vertical bar to be non-interfering.
- the rotating plate of the plate stopper is urged by an elastic body in a direction in which the vertical bar is arranged at the interference position. Then, as long as no external force acts on the rotating plate, the vertical bar is arranged at the interference position. Therefore, only when the vertical bar is arranged at the non-interfering position, an external force acts on the rotating plate.
- the mechanism for operating the plate stopper can be simplified.
- One example of the elastic body is a torsion spring.
- a stopper for stopping the rotating operation of the rotating body is provided so that the rotating plate is not pressed by the shaft and stops in a state where the vertical bar is disposed at the interference position.
- the plate changer for an autosampler is configured such that the plate storage is arranged such that when the sample plate inserted from the installation window reaches a predetermined position on the plate installation table, the sample window is moved toward the transfer window.
- a plate stopper which is located at the interference position in contact with the end surface of the plate and stops the sample plate, is provided in the transfer window, so that when the sample plate is inserted from the installation window of the plate storage, It is possible to prevent the plate from being pushed too far and falling from the plate mounting table. Then, when the sample plate on the plate mounting table is taken out of the transfer window by the holding portion of the transfer mechanism, the plate stopper is configured to be disposed at a non-interfering position that does not interfere with the holding portion and the sample plate. Therefore, the plate stopper does not hinder the operation of taking out the sample plate by the transport mechanism.
- the plate changer 1 includes a plate storage 2 and a transport mechanism 4.
- the plate storage 2 is for storing and storing a plurality of sample plates P inside the housing 6.
- Examples of the sample plate P include a well plate in which a plurality of wells containing a sample are provided on an upper surface, and a vial plate in which a plurality of holes for receiving a plurality of sample vials containing a sample are provided on an upper surface. Any plate may be used as long as it is used in an autosampler.
- the plate storage 2 has a plurality of plate setting tables 8 on which the sample plates P are set.
- the plate mounting tables 8 are arranged side by side in the vertical direction, and one sample plate P is mounted on each plate mounting table 8.
- the plate storage 2 has an installation window 10 on the front side and a transport window 12 on the back side.
- the installation window 10 and the transport window 12 are openings provided at positions facing each other in the housing 6.
- the installation window 10 is for the user to install the sample plate P on a desired plate installation table 8 and to take out the sample plate P installed on the plate installation table 8.
- An opening / closing door 14 for opening and closing the installation window 10 is provided on the front surface of the plate storage 2.
- the sample plate P is set on the plate setting table 8 in one direction in a horizontal plane indicated by an arrow in the figure, that is, in a direction from the setting window 10 side to the transfer window 12 side. It is performed by sliding on the plate mounting table 8.
- the removal of the sample plate P from the plate mounting table 8 is performed by sliding the sample plate P in a direction opposite to the direction at the time of installation, that is, in a direction from the transport window 12 side toward the installation window 10 side. .
- the transport window 12 is for the transport mechanism 4 to place the sample plate P on a predetermined plate mounting table 8 or to take out the sample plate P placed on the plate mounting table 8.
- the transport mechanism 4 is moved in the horizontal plane direction and the vertical direction on the back side of the plate storage 2 by a drive mechanism (not shown).
- the transport mechanism 4 includes a pair of arms 16 extending parallel to each other and horizontally.
- the two arms 16 extend in parallel with the sliding direction of the sample plate P in the plate storage 2.
- the transport mechanism 4 can adjust the interval between the two arms 16 variably, and can hold the sample plate P between the two arms 16 and hold the side surface of the sample plate P.
- the two arms 16 constitute a holding part for holding the side surface of the sample plate P.
- the transport mechanism 4 inserts the two arms 16 into the plate storage 2 from the transport window 12 side of the plate storage 2, and the sample plate set on the plate setting table 8 in the plate storage 2. By holding the side surface of P and sliding the sample plate P, the sample plate P is taken out of the plate storage 2 and transported to a predetermined destination.
- the transport destination of the sample plate P is, for example, an autosampler used for a liquid chromatograph. Further, the transport mechanism 4 transports the sample plate P on which the sample processing has been completed to the plate storage 2, and places the sample plate P on a predetermined plate mounting table 8 in the plate storage 2, on the transport window 12. Insert and install.
- the plate storage 2 is provided with a temperature controller such as a heater or a Peltier element for adjusting the temperature of the sample plate P stored in the housing 6 to a preset temperature.
- a temperature controller such as a heater or a Peltier element for adjusting the temperature of the sample plate P stored in the housing 6 to a preset temperature.
- a mechanism (not shown) may be provided.
- the plate storage 2 has an end surface on the transport window 12 side of the sample plate P.
- the transport window 12 is provided with a plate stopper 24 for preventing the sample plate P from dropping from the plate mounting table 8 in contact with the plate.
- the plate stopper 24 includes a vertical bar 26 extending vertically between the upper end and the lower end of the plate storage 2, and an upper end of the vertical bar 26 provided at each of the upper and lower ends of the plate storage 2. It is constituted by a rotating plate 28 which can hold a lower end portion and can rotate in a horizontal plane (only the lower end side rotating plate 28 is shown in FIG. 2).
- the plate stopper 24 is configured such that the vertical bar 26 is moved in conjunction with the opening / closing operation of the opening / closing door 14 of the installation window 10 of the plate storage 2.
- Shafts 20 and 22 (see FIG. 1) extending horizontally from the installation window 10 to the transport window 12 are provided at the upper end and the lower end of the plate storage 2, respectively.
- the vertical bar 26 of the plate stopper 24 is an end surface of the sample plate P inserted to a predetermined position on the plate installation table 8 on the side of the transport window 12.
- a non-interference position the position does not interfere with the operation of the arm 16 of the transport mechanism 4 that attempts to take out the sample plate P on the plate mounting table 8 (hereinafter, a non-interference position).
- FIGS. 3 and 4 show the structure on the lower end side of the plate storage 2, the structure on the upper end side of the plate storage 2 is the same.
- the rotating plate 28 holding the vertical bar 26 is rotatably supported by a shaft 30 in a horizontal plane.
- a torsion spring 32 which is an elastic body, is attached to the shaft 30, and the rotating plate 28 is urged by the torsion spring 32 in a direction (clockwise direction in the drawing) in which the vertical bar 26 is arranged at the interference position.
- a stopper 34 for stopping the rotation of the rotary plate 28 at a position where the vertical bar 26 is located at the interference position is provided on the floor surface on which the rotary plate 28 is disposed. Accordingly, in a state where no external force acts on the rotating plate 28, that is, in a state where the opening / closing door 14 is open (a state in FIG. 3), the vertical bar 26 is always arranged at the interference position.
- reference numeral 8a indicated by a broken line denotes a plate guide provided on the plate mounting table 8.
- the plate guide 8a is for supporting both side surfaces of the sample plate P so that the sample plate P inserted from the installation window 10 is arranged in a correct posture.
- the plate guide 8a comes into contact with the arm 16 when the arm 16 (see FIG. 1) of the transport mechanism 4 enters the plate setting table 8 from the transport window 12 to take out the sample plate P. It is configured to move to a position that does not interfere with the operation of the arm 16, for example, a position below the upper surface of the plate mounting table 8.
- the rotating plate 28 is provided with a shaft contact portion 36 which is always in contact with the end of the shaft 22 on the side of the transport window 12.
- the shaft 22 is moved to the transport window 12 side (upward in the drawing) by the opening / closing door 14, and the shaft contact portion 36 is moved by the shaft 22. It is pressed and moved toward the transport window 12 side.
- the rotating plate 28 rotates, and the vertical bar 26 moves to a position near the side surface in the plate storage 2, that is, a non-interference position.
- the position of the vertical bar 26 at this time is a position that does not interfere with the operation of the arm 16 of the transport mechanism 4 that attempts to remove the sample plate P from the plate storage 2 or the sample plate P that is removed from the plate storage 2.
- the structure of the plate stopper for preventing the sample plate P from falling is not limited to the above-described embodiment.
- the rotating plate 28 of the plate stopper 24 in the above embodiment may be driven by a motor, and the plate stopper 24 may be operated according to the operation of the transport mechanism 4, or a sensor for detecting the open / closed state of the door 14. May be provided so that the operation of the plate stopper 24 is linked to the open / closed state of the door 14.
- the arm 16 of the transport mechanism 4 enters the plate storage 2
- a part of the plate stopper comes into contact with the arm 16, and the plate stopper moves from the interference position in conjunction with the movement of the arm 16. You may comprise so that it may move to a non-interference position.
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
Description
2 プレート保管庫
4 搬送機構
6 筐体
8 プレート設置台
10 設置用窓部
12 搬送用窓部
14 開閉扉
16 アーム
20,22 シャフト
24 プレートストッパ
26 鉛直棒
28 回転板
30 軸
32 トーションバネ
34 ストッパ
36 シャフト接触部
P サンプルプレート
Claims (8)
- サンプルプレートを設置するためのプレート設置台を内部に有し、前記サンプルプレートを水平面内における一方向へ挿入して前記プレート設置台に設置するための設置用窓部、及び前記設置用窓部とは前記プレート設置台を挟んで反対側に設けられて前記プレート設置台に設置された前記サンプルプレートを前記一方向へ取り出すための搬送用窓部が設けられているプレート保管庫と、
サンプルプレートを把持する把持部を有し、前記プレート設置台に設置されているサンプルプレートを前記把持部で把持して搬送する搬送機構と、を備え、
前記プレート保管庫は、前記設置用窓部から挿入されるサンプルプレートが前記一方向における前記プレート設置台上の所定の位置まで到達したときに前記サンプルプレートの前記搬送用窓部側の端面に接する干渉位置に配置されて前記サンプルプレートを停止させるプレートストッパを前記搬送用窓部に有し、
前記プレートストッパは、前記把持部によって前記プレート設置台上のサンプルプレートが前記搬送用窓部から取り出される際に、前記把持部及び前記サンプルプレートに干渉しない非干渉位置に配置されるように構成されている、オートサンプラ用のプレートチェンジャ。 - 前記プレートストッパは、鉛直方向へ延びる鉛直棒と、前記鉛直棒の一端を保持しながら水平面内において回転可能な回転板と、を備えており、前記回転板が水平面内において回転することにより前記鉛直棒が前記干渉位置と前記非干渉位置との間で移動するように構成されている、請求項1に記載のプレートチェンジャ。
- 前記プレートストッパは、2つの前記回転板を備え、それらの前記回転板が前記鉛直棒の上端及び下端をそれぞれ保持している、請求項2に記載のプレートチェンジャ。
- 前記設置用窓部を開閉するための開閉扉を備え、
前記プレートストッパの前記鉛直棒は、前記開閉扉が開いているときに前記干渉位置に配置され、前記開閉扉が閉じられると前記非干渉位置に配置されるように構成されている、請求項2又は3に記載のプレートチェンジャ。 - 前記一方向へ延び、前記開閉扉が閉じられるときの動作に連動して前記搬送用窓部側へ移動するシャフトを備え、
前記開閉扉が閉じられるときに前記シャフトが前記搬送用窓部側へ移動して前記プレートストッパの前記回転板の一部を押圧して前記回転板を回転させ、前記鉛直棒を前記非干渉位置へ移動させるように構成されている、請求項4に記載のプレートチェンジャ。 - 前記プレートストッパの前記回転板は弾性体によって前記鉛直棒を前記干渉位置に配置する方向に付勢されている、請求項5に記載のプレートチェンジャ。
- 前記弾性体はトーションバネである、請求項6に記載のプレートチェンジャ。
- 前記回転板が前記シャフトにより押圧されていない状態で、前記鉛直棒が前記干渉位置に配置された状態で停止するように、前記回転体の回転動作を停止させるストッパをさらに備えている、請求項6又は7に記載のプレートチェンジャ。
Priority Applications (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2018/034027 WO2020054033A1 (ja) | 2018-09-13 | 2018-09-13 | オートサンプラ用のプレートチェンジャ |
| JP2020546634A JP7180677B2 (ja) | 2018-09-13 | 2018-09-13 | オートサンプラ用のプレートチェンジャ |
| US17/275,792 US12181486B2 (en) | 2018-09-13 | 2018-09-13 | Plate changer for auto-sampler |
| CN201880097515.4A CN112703404B (zh) | 2018-09-13 | 2018-09-13 | 自动进样器用的换板器 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/JP2018/034027 WO2020054033A1 (ja) | 2018-09-13 | 2018-09-13 | オートサンプラ用のプレートチェンジャ |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2020054033A1 true WO2020054033A1 (ja) | 2020-03-19 |
Family
ID=69778493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/JP2018/034027 Ceased WO2020054033A1 (ja) | 2018-09-13 | 2018-09-13 | オートサンプラ用のプレートチェンジャ |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US12181486B2 (ja) |
| JP (1) | JP7180677B2 (ja) |
| CN (1) | CN112703404B (ja) |
| WO (1) | WO2020054033A1 (ja) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11899030B2 (en) | 2018-11-02 | 2024-02-13 | Shimadzu Corporation | Plate changer and chromatograph including the plate changer |
| WO2024261826A1 (ja) * | 2023-06-19 | 2024-12-26 | 平田機工株式会社 | 標本格納庫および標本作製装置 |
| WO2025041270A1 (ja) * | 2023-08-22 | 2025-02-27 | 株式会社日立ハイテク | 容器架設装置、及び、容器 |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7470943B2 (ja) * | 2020-06-09 | 2024-04-19 | 横河電機株式会社 | 解析装置 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US6228636B1 (en) | 1998-09-21 | 2001-05-08 | Matsushita Electric Industrial Co., Ltd. | Incubator |
| JP2005073623A (ja) * | 2003-09-02 | 2005-03-24 | Yec Co Ltd | 温度調整機能を有する容器の扉開閉装置 |
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2018
- 2018-09-13 US US17/275,792 patent/US12181486B2/en active Active
- 2018-09-13 JP JP2020546634A patent/JP7180677B2/ja active Active
- 2018-09-13 WO PCT/JP2018/034027 patent/WO2020054033A1/ja not_active Ceased
- 2018-09-13 CN CN201880097515.4A patent/CN112703404B/zh active Active
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|---|---|---|---|---|
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| JPH06504134A (ja) * | 1991-10-31 | 1994-05-12 | マイクロスキャン、インコーポレイテッド | 処理の間標本トレーを保持するためのステーションを備えた標本処理及び分析システム |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11899030B2 (en) | 2018-11-02 | 2024-02-13 | Shimadzu Corporation | Plate changer and chromatograph including the plate changer |
| WO2024261826A1 (ja) * | 2023-06-19 | 2024-12-26 | 平田機工株式会社 | 標本格納庫および標本作製装置 |
| WO2025041270A1 (ja) * | 2023-08-22 | 2025-02-27 | 株式会社日立ハイテク | 容器架設装置、及び、容器 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112703404A (zh) | 2021-04-23 |
| JP7180677B2 (ja) | 2022-11-30 |
| US20220050122A1 (en) | 2022-02-17 |
| CN112703404B (zh) | 2025-01-10 |
| JPWO2020054033A1 (ja) | 2021-08-30 |
| US12181486B2 (en) | 2024-12-31 |
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