WO2020045413A1 - Antiviral composition, anti-norovirus composition, spray, and wiper - Google Patents

Abstract

The present invention addresses the problem of providing an antiviral composition that exhibits an excellent antiviral activity. The present invention also addresses the problem of providing an anti-norovirus composition, a spray, and a wiper that use the antiviral composition. The antiviral composition according to the present invention comprises inorganic particles and a solvent and has a pH of 9.0 to 13.5. The inorganic particles include inorganic particles containing a first metal and inorganic particles containing a second metal that is different from the first metal.

Description

Anti-viral composition, anti-norovirus composition, spray, wiper

The present invention relates to an antiviral composition, an anti-norovirus composition, a spray, and a wiper.

Unlike microorganisms such as bacteria and fungi, which have a cell structure, a virus has no cell structure and has a genome in an outer protein called capsid. Viruses are roughly classified into two types depending on whether their genomes are DNA (deoxyribonucleic acid) or RNA (ribonucleic acid). The capsid is covered with an envelope composed of a lipid bilayer, and the enveloped virus is not covered with an envelope. It is further classified according to whether it is a membrane virus. Specifically, human herpes virus and hepatitis B virus and the like are included in the DNA type membrane virus, and adenovirus and B19 virus and the like are included in the DNA type membraneless virus such as the adenovirus and B19 virus. , Influenza virus, and membrane-type viruses of the RNA type such as SARS (severe acute respiratory syndrome) coronavirus include norovirus, poliovirus, and enterovirus.

For example, Patent Document 1 discloses an anti-norovirus composition containing a grapefruit seed extract (Claim 2).

JP 2009-292736 A

The present inventors prepared an antibacterial composition described in the Examples section of Patent Document 1 and analyzed feline calicivirus (a closely related species of norovirus, genomic composition similar to norovirus, capsid structure and biochemical Investigations on the antiviral activity against the most widely used surrogate virus because of its properties revealed that there is room for further improvement in the antiviral activity.

Therefore, an object of the present invention is to provide an antiviral composition having excellent antiviral activity.
Another object of the present invention is to provide a composition for anti-norovirus, a spray, and a wiper using the composition for anti-virus.

The present inventors have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that the above-mentioned problems can be solved by using an antiviral composition having a predetermined composition, thereby completing the present invention.
That is, the inventors have found that the above-described problems can be solved by the following configuration.

[1] An antiviral composition comprising inorganic particles and a solvent and having a pH of 9.0 to 13.5,
An antiviral composition comprising, as the inorganic particles, inorganic particles containing a first metal and inorganic particles containing a second metal different from the first metal.
[2] The inorganic particles containing the first metal include a simple substance of the first metal, an oxide of the first metal, and an inorganic carrier and the first metal supported on the inorganic carrier. The antiviral composition according to [1], which is at least one selected from the group consisting of metal-carrying inorganic carriers.
[3] The inorganic particles containing the second metal include a simple substance of the second metal, an oxide of the second metal, an inorganic carrier, and the second metal supported on the inorganic carrier. The antiviral composition according to [1] or [2], which is at least one selected from the group consisting of metal-carrying inorganic carriers.
[4] The antiviral composition according to [2] or [3], wherein the inorganic carrier is glass.
[5] The antiviral composition according to any one of [1] to [4], wherein the first metal is copper and the second metal is silver.
[6] The inorganic particle containing the first metal is a copper-supported silicate glass having silicate glass and copper supported on the silicate glass, [1] to [5]. The antiviral composition according to any one of the above.
[7] The antiviral composition according to [6], wherein the inorganic particles containing the first metal have an average particle size of 0.5 μm or less.
[8] The inorganic particle containing the second metal is a silver-supported phosphate glass having a phosphate glass and silver supported on the phosphate glass, [1] to [7]. The antiviral composition according to any one of the above.
[9] The antiviral composition according to any one of [1] to [8], wherein the solvent contains an alcohol.
[10] The antiviral composition according to [9], wherein the alcohol contains ethanol.
[11] The antiviral composition according to [10], wherein the content of the ethanol is less than 60% by mass based on the total mass of the solvent.
[12] The antiviral composition according to any one of [1] to [11], which has a pH of 9.0 to 11.5.
[13] The antiviral composition according to any one of [1] to [12], which is a liquid.
[14] The antiviral composition according to any one of [1] to [12], which is a gel.
[15] A composition for anti-norovirus, comprising the composition for anti-virus according to any one of [1] to [14].
[16] A spray comprising: a spray container; and the antiviral composition according to any one of [1] to [14] contained in the spray container.
[17] A wiper comprising: a base fabric; and the antiviral composition according to any one of [1] to [14] impregnated in the base fabric.

According to the present invention, an antiviral composition having excellent antiviral activity can be provided.
Further, according to the present invention, it is possible to provide an anti-norovirus composition, a spray, and a wiper using the anti-virus composition.

Hereinafter, the present invention will be described in detail.
The description of the constituent elements described below may be made based on typical embodiments of the present invention, but the present invention is not limited to such embodiments.
In the notation of a group (atom group) in the present specification, the notation of not indicating substituted or unsubstituted includes those having no substituent and those having a substituent within a range not impairing the effects of the present invention. Is also included. For example, the “alkyl group” includes not only an alkyl group having no substituent (unsubstituted alkyl group) but also an alkyl group having a substituent (substituted alkyl group). This is synonymous with each compound.
In this specification, “(meth) acrylate” represents both or any of acrylate and methacrylate, “(meth) acryl” represents both or any of acryl and methacryl, and “(meth) acrylate”. ) "Acryloyl" represents acryloyl and / or methacryloyl.
Further, in this specification, a numerical range represented by using “to” means a range including numerical values described before and after “to” as a lower limit and an upper limit.

[Composition for antivirus]
The antiviral composition (hereinafter also referred to as “composition”) is an antiviral composition containing inorganic particles and a solvent and having a pH of 9.0 to 13.5,
As the inorganic particles, an inorganic particle containing a first metal (hereinafter also referred to as “inorganic particle (1)”) and an inorganic particle containing a second metal different from the first metal (hereinafter “inorganic particles ( 2) ").
In the present specification, when simply referred to as “metal”, a simple metal (simple metal particle), a metal ion, and a compound (definition of compound: can be classified into two or more elements by chemical change. Pure substance).

(4) The composition of the present invention is remarkably excellent in antiviral activity (especially, antiviral activity against feline calicivirus (a related species of norovirus)) due to the above constitution. The composition of the present invention comprises an enzyme (uretase) that degrades urea such as microorganisms such as bacteria and fungi (eg, microorganisms such as Escherichia coli, staphylococci, and genus Proteus (eg, P. mirabilis, P. vulgaris)). ) Are also confirmed to be excellent in antibacterial activity against).

組成 The composition of the present invention can be used for applications used to reduce the activity of a virus by acting on the virus. In particular, it is preferably used as a composition for anti-norovirus. The composition of the present invention produces an enzyme (uretase) that degrades urea such as microorganisms such as bacteria and fungi (for example, Escherichia coli, staphylococci, and genus Proteus (for example, P. mirabilis, P. vulgaris)). Microorganisms) to reduce the activity of the microorganisms.

The mechanism of action of the present invention is not clear in detail, but the present inventors speculate as follows.
In the composition of the present invention, the inorganic particles (1) and (2) function as an active ingredient (antiviral component).
The metal in the inorganic particles (1) and (2) easily elutes metal ions by adjusting the pH to a predetermined range in the presence of a solvent. As a result, the composition has an antiviral activity. Presumed to be excellent.
In particular, it has been confirmed that when the first metal is copper and the second metal is silver, the composition has better antiviral activity. In particular, when the composition contains copper-supported silicate glass as the inorganic particles (1) and the inorganic particles (2) contain silver, the composition is more excellent in antiviral activity.

各種 Various components contained in the antiviral composition are described below.

[Inorganic particles (1)]
The inorganic particles (1) include a first metal.
The form of the inorganic particles (1) is not particularly limited, and examples thereof include a simple substance of the first metal (metal single particles), an inorganic compound containing the first metal, and the like. Further, the inorganic particles (1) may be a composite of an inorganic compound and a first metal. Examples of the composite include an inorganic carrier and a first metal supported on the inorganic carrier (for example, a simple substance of the first metal (simple metal particle) or an ion of the first metal). And a metal-containing inorganic carrier (hereinafter, also referred to as “first metal-supported inorganic carrier”).
Above all, from the viewpoint that the effects of the present invention are more excellent, the inorganic particles (1) are selected from the group consisting of a simple substance (particle) of a first metal, an oxide of a first metal, and a first metal-carrying inorganic carrier. At least one of these is preferred, and the first metal-carrying inorganic carrier is more preferred.

Examples of the first metal include, but are not particularly limited to, copper, silver, zinc, mercury, iron, lead, bismuth, titanium, tin, aluminum, zirconium, and nickel. Among them, copper, silver, zinc, Aluminum or zirconium is preferred, copper, silver, zinc, or aluminum is more preferred, copper or silver is more preferred, and copper is particularly preferred.

The inorganic particles (1) may be, for example, a first metal oxide, nitride, halide, cyanide, selenide, sulfide, telluride, and a salt of the first metal.
Examples of the salt of the first metal include, for example, arsenate, hydrogen fluoride, bromate, chlorate, chromate, cyanate, hexafluoroantimonate, hexafluoroarsenate, hexafluoroarsenate Phosphate, iodate, isothiocyanate, molybdate, nitrate, nitrite, perchlorate, permanganate, perrhenate, phosphate, selenate, selenite, sulfuric acid Salts, sulfites, tetrafluoroborates, tetratungstates, thiocyanates, vanadates and the like.

Although the kind of the inorganic carrier of the first metal-supporting inorganic carrier is not particularly limited, zinc calcium phosphate, calcium phosphate, zirconium phosphate, aluminum phosphate, calcium silicate, activated alumina, silicon oxide, silicate, borosilicate , Phosphate, zeolite (crystalline aluminosilicate salt), apatite, hydroxyapatite, titanium phosphate, potassium titanate, bismuth hydroxide, zirconium hydroxide, hydrotalcite, activated carbon, metal and the like.
In addition, in this specification, the inorganic support of the first metal-carrying inorganic support may be referred to as “first inorganic support”.

The inorganic carrier may be crystalline or amorphous (amorphous), but is preferably amorphous. In other words, glass is preferred as the inorganic carrier.
Examples of a material that can constitute glass include silicate, borosilicate, and phosphate (in other words, silicate glass, borosilicate glass, and phosphate glass). Of these, silicates are preferred.
The silicate preferably contains one or more atoms selected from the group consisting of alkali metals and alkaline earth metals, and more preferably aluminum silicate.

The aluminum silicate may be a natural product or a synthetic product. As the aluminum silicate, a compound represented by the following formula (A) is preferable.
Al ₂ O ₃ .nSiO ₂ .mH ₂ O (A)
In the formula (A), n is a positive number of 6 or more (preferably 6 to 50), and m is a positive number of 1 to 20. Especially, it is preferable that n is 8 to 15 and m is 3 to 15.

As the first metal-carrying inorganic carrier, a metal-carrying zeolite, a metal-carrying apatite, a metal-carrying glass, a metal-carrying zirconium phosphate, or a metal-carrying calcium silicate, on which a first metal is supported, is more preferable. preferable.

The average particle size of the inorganic particles (1) is not particularly limited, but is, for example, 2.0 μm or less, and is preferably 1.5 μm or less, more preferably 1.0 μm or less, in that the antiviral activity is more excellent. It is more preferably 0.5 μm or less, particularly preferably 0.2 μm or less. The lower limit is preferably 0.01 μm or more, more preferably 0.05 μm or more, and particularly preferably 0.1 μm or more.

The average particle size of the inorganic particles (1) can be measured by observation using an electron microscope. Specifically, the above average particle diameter is determined for inorganic particles (1) by primary particles and secondary particles ("secondary particles" refers to an aggregate formed by fusing or contacting primary particles with each other. Is defined from the image of the electron microscope, and 90% of the total number of particles except for 5% of the number of particles having the smallest diameter and 5% of the number of particles having the largest diameter is excluded. It is the average of the diameters of the particles in the range. That is, the average particle size is a value obtained from the primary particles and the secondary particles. The diameter refers to a diameter corresponding to a circumscribed circle of the particle.
When there is no significant difference in the particle shape of the inorganic particles (1), the 50% volume cumulative diameter (D50) was measured three times using a laser diffraction / scattering type particle size distribution analyzer manufactured by Horiba, Ltd. The average value of the times measured may be used as the average particle size.

The method for forming the inorganic particles (1) may be any of a breakdown method (for example, a pulverization method) and a build-up method.
Examples of the method for pulverizing the inorganic particles (1) include dry pulverization and wet pulverization. In the dry pulverization, for example, a mortar, a jet mill, a hammer mill, a pin mill, a rotary mill, a vibration mill, a planetary mill, a bead mill, and the like are appropriately used. In wet pulverization, various ball mills, high-speed rotary pulverizers, jet mills, bead mills, ultrasonic homogenizers, high-pressure homogenizers, and the like are appropriately used. For example, in a bead mill, the average particle diameter can be controlled by adjusting the diameter, type, mixing amount, and the like of beads serving as media.

The build-up method is a method of directly forming the inorganic particles (1) by, for example, mixing a raw material component such as a hydroxide and an organometallic material with an arbitrary component and performing a reaction.
The build-up method may be a batch method in which raw materials are added to a pod and stirred and mixed, or a system in which raw materials are continuously mixed and reacted in a flow path (for example, a microreactor or a double tube). Mixing method), but the latter is preferred.

The aspect ratio of the inorganic particles (1) is not particularly limited, but is preferably 1 to 10, and more preferably 2 to 8.
The aspect ratio is calculated by the following method. First, using an electron microscope, of the two parallel straight lines circumscribing the inorganic particles (1), two parallel straight lines having the maximum distance between the straight lines are selected, and the distance between the two parallel straight lines is determined. The long axis of the inorganic particles (1). Next, of the two parallel straight lines orthogonal to the long axis and circumscribing the inorganic particles (1), two parallel straight lines having the minimum distance between the straight lines are selected. Is the short axis of the inorganic particles (1). The obtained ratio of the major axis to the minor axis (major axis / minor axis) is defined as a specific aspect ratio. This operation is performed for any 100 or more inorganic particles (1), and the obtained specific aspect ratio is arithmetically averaged to obtain the above aspect ratio.

The content of the inorganic particles (1) in the composition is not particularly limited, but is preferably 0.01 to 10% by mass, more preferably 0.01 to 5.0% by mass, based on the total mass of the composition. The content is more preferably 0.01 to 3.0% by mass.

[Inorganic particles (2)]
The inorganic particles (2) include a second metal.
The second metal is different from the first metal. Here, “different” means that the types of metal elements are different.
Examples of the second metal include, but are not particularly limited to, silver, copper, zinc, mercury, iron, lead, bismuth, titanium, tin, zirconium, aluminum, nickel, and the like, and silver, copper, zinc, aluminum, or Zirconium is preferred, and silver is more preferred.

The form of the inorganic particles (2) is not particularly limited, and includes a simple substance (particle) of a second metal, an inorganic compound containing the second metal, and the like. Further, the inorganic particles (2) may be a composite of an inorganic compound and a second metal. Examples of the composite include an inorganic carrier and a second metal supported on the inorganic carrier (for example, a simple substance of a second metal (metal single particle) or an ion of the second metal) or a second metal. And a metal-containing inorganic carrier (hereinafter, also referred to as a “second metal-supported inorganic carrier”).
Above all, from the viewpoint that the effects of the present invention are more excellent, the inorganic particles (2) are selected from the group consisting of a simple substance (particle) of a second metal, an oxide of a second metal, and a second metal-carrying inorganic carrier. Preferably, at least one of these is used, the second metal-carrying inorganic carrier is more preferable, and the second metal-carrying inorganic carrier supporting the ion of the second metal is even more preferable.

As the inorganic carrier of the second metal-carrying inorganic carrier, the same inorganic carriers as those described for the first metal-carrying inorganic carrier can be used.

The inorganic carrier may be crystalline or amorphous, but is preferably amorphous. In other words, glass is more preferable as the inorganic carrier. Examples of the material that can constitute glass include silicate, borosilicate, and phosphate (in other words, silicate glass, borosilicate glass, and phosphate glass). However, phosphates are preferred.

Specific examples of the second metal-carrying inorganic carrier are preferably a metal-carrying zeolite, a metal-carrying apatite, a metal-carrying glass, a metal-carrying zirconium phosphate, or a metal-carrying calcium silicate on which a second metal is supported. Is more preferred.

場合 When the second metal-supported inorganic carrier is a metal-supported glass, silver-supported phosphate glass is particularly preferred in that the metal-eluting ability is excellent.

In particular, the inorganic particles (1) are copper-supported silicate glasses (preferably, the silicate glasses are preferably aluminum silicate glasses), and the inorganic particles (2) are more excellent in antiviral activity. Is preferably a silver-supported phosphate glass.
Silicate glass is superior to phosphate glass in its ability to adsorb silver. Therefore, when the inorganic particles (1) are copper-supported silicate glass and the inorganic particles (2) are silver-supported silicate glass, silver eluted from the silver-supported silicate glass is copper-supported silicate. It is presumed that it becomes easy to transfer to glass and a coexistence state in which silver and copper are supported on a silicate glass carrier can be formed. As a result, it is believed that the antiviral activity of the composition is even better.

As the inorganic substance (2), for example, an oxide, a nitride, a halide, a cyanide, a selenide, a sulfide, a telluride, a salt of the first metal, or the like of the second metal may be used.
Examples of the salt of the second metal include, for example, arsenate, hydrogen fluoride, bromate, chlorate, chromate, cyanate, hexafluoroantimonate, hexafluoroarsenate, hexafluoroarsenate Phosphate, iodate, isothiocyanate, molybdate, nitrate, nitrite, perchlorate, permanganate, perrhenate, phosphate, selenate, selenite, sulfuric acid Salts, sulfites, tetrafluoroborates, tetratungstates, thiocyanates, vanadates and the like.

The average particle size of the inorganic particles (2) is not particularly limited, but is generally 0.01 μm or more, and preferably 0.1 μm or more. The upper limit is not particularly limited, but is, for example, 3.0 μm or less, and is preferably 1.0 μm or less, and more preferably 0.6 μm or less from the viewpoint of more excellent antiviral activity.
When the sedimentation property and the transparency of the composition are taken into consideration, the smaller the average particle size of the inorganic particles (2), the better the dispersibility, and as a result, the transparency of the composition tends to increase. The average particle size of the inorganic particles (2) is preferably 0.5 μm or less, more preferably 0.4 μm or less, in that the transparency of the composition is more excellent.
For the measurement and adjustment of the average particle size of the inorganic particles (2), the above-described methods for measuring and adjusting the average particle size of the inorganic particles (1) can be used.

As the inorganic particles (2), one type may be used alone, or two or more types may be used in combination.
The content of the inorganic particles (2) in the composition (when a plurality of inorganic particles (2) are contained, the total content thereof) is not particularly limited, but is preferably 0.001 to 10% based on the total mass of the composition. % By mass, more preferably 0.001 to 5.0% by mass, even more preferably 0.001 to 3.0% by mass.

The content of the metal in the inorganic particles (2) is not particularly limited. For example, when the inorganic particles (2) are a metal-supporting inorganic carrier, the content of the metal is based on the total mass of the metal-supporting inorganic carrier. The content is preferably 0.001 to 30% by mass, more preferably 0.01 to 10% by mass. When the composition contains a plurality of inorganic particles (2), the total content of metals is preferably within the above numerical range.

〔solvent〕
The composition of the present invention contains a solvent.
The solvent is not particularly limited, but preferably contains an alcohol in that the antiviral activity of the composition is more excellent.

<Alcohol>
The alcohol is not particularly limited, but is preferably, for example, a linear, branched, or cyclic alcohol having 1 to 20 carbon atoms (including an ether alcohol). Specifically, methanol, ethanol, n-propanol, isopropanol, polyethylene glycol, propylene glycol, propylene glycol acetic acid monoester, glycerin, n-butanol, 2-butanol, i-butanol, t-butanol, butane-1,3 Diol, diethylene glycol, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, dipropylene glycol, n-pentanol, 2-pentanol, 3-pentanol, t-amyl alcohol, isoamyl alcohol, 2-methylbutanol, 3-methyl -2-butanol, 3-methyl-2-butenol, 3-methyl-3-butanol, 1-penten-3-ol, n-hexanol, caprylic alcohol, 2-ethyl- Hexanol, decanol, linalool, geraniol, lauryl alcohol, myristyl alcohol, benzyl alcohol, phenylethyl alcohol, cinnamyl alcohol, 3-methoxypropanol, methoxymethoxyethanol, ethylene glycol, ethylene glycol mono-n-butyl ether, diethylene glycol mono-n -Butyl ether, triethylene glycol mono-n-butyl ether, tetraethylene glycol mono-n-butyl ether, dipropylene glycol monobutyl ether, citronellol, terpineol, hydroxycitronellal, hydroxycitronellal dimethyl acetal, ethylene glycol monomethyl ether, ethylene glycol Monoethyl ether, propylene glycol Monomethyl ether, propylene glycol monoethyl ether, diacetone alcohol, ethylene glycol monoisopropyl ether, and diethylene glycol monomethyl ether, and the like.

The alcohol is preferably a food additive from the viewpoint of safety. Among them, methanol, ethanol, propanol, isopropanol, polyethylene glycol, propylene glycol, propylene glycol acetic acid monoester, n-butanol, 2-butanol, butane -1,3-diol, diethylene glycol, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, dipropylene glycol, 2-methyl-1-butanol, 1-decanol, 1-penten-3-ol, 2-ethyl 1-hexanol, 2-pentanol, 3-pentanol, 3-methyl-2-butanol, 3-methyl-2-butenol, 3-methyl-3-butanol, isoamyl alcohol, i-butanol, Benzyl alcohol, citronellol, terpineol, hydroxy citronellal, or hydroxy citronellal dimethyl acetal is preferred, ethanol or isopropanol is more preferable, and ethanol is more preferred.

<Solvents other than alcohol>
The solvent of the composition of the present invention may be a solvent other than alcohol.
Examples of the solvent other than the alcohol include water and an organic solvent (excluding the alcohol).
The organic solvent is not particularly limited, for example, acetone, methyl ethyl ketone, cyclohexane, ethyl acetate, isoamyl acetate, isopropyl acetate, geranyl acetate, cyclohexyl acetate, citronellyl acetate, cinnamyl acetate, terpinyl acetate, phenylethyl acetate, butyl acetate, acetic acid Benzyl, menthyl acetate, linalyl acetate, butyric acid, ethyl butyrate, butyl butyrate, isoamyl butyrate, cyclohexyl butyrate, ethylene dichloride, tetrahydrofuran, toluene, ethylene glycol dimethyl ether, acetylacetone, cyclohexanone, ethylene glycol monomethyl ether acetate, ethylene glycol ethyl ether acetate, ethylene Glycol monobutyl ether acetate, diethylene glycol dimethyl ether, Ethylene glycol diethyl ether, propylene glycol monomethyl ether acetate, 2-methylpropanal, 2-methylbutyraldehyde, 3-methyl-2-butenal, 3-methylbutanal, L-perylaldehyde, acetaldehyde, ethyl acetoacetate, isoamyl acetate , Isoamyl butyrate, isovaleraldehyde, isobutanal, isopropyl acetate, isopropyl myristate, isoamyl isovalerate, ethyl isovalerate, ethyl lactate, ethyl heptanoate, octanal, ethyl octanoate, octanal, octanoic acid, ethyl octanoate, Octylaldehyde, formic acid, isoamyl formate, geranyl formate, citronellyl formate, cinnamic aldehyde, ethyl cinnamate, methyl cinnamate, citral, citronellal Diisopropyl ether, diisopropyl disulfide, diisopropyl disulfide, diethyl ether, diethyl tartrate, diethyl pyrocarbonate, decanal, ethyl decanoate, triacetin, triethyl citrate, toluene, nonalactone, valeraldehyde, paramethylacetophenone, paramethoxybenzaldehyde, castor oil , Isoamyl phenylacetate, isobutyl phenylacetate, ethyl phenylacetate, butanal, propionaldehyde, propionic acid, isoamyl propionate, ethyl propionate, benzyl propionate, hexane, heptane, benzaldehyde, eucalyptol, ionone, terpinyl acetate, α- Amyl cinnamaldehyde, brominated vegetable oil, acetic acid, dimethyl dicarbonate, ethyl lactate, large thermal oxidation Oil, thermal oxidation soybean oil and esters of glycerol, and liquid paraffin, and the like.

The organic solvent is preferably a food additive from the viewpoint of safety, acetone, methyl ethyl ketone, ethyl acetate, isoamyl acetate, isopropyl acetate, geranyl acetate, cyclohexyl acetate, citronellyl acetate, cinnamyl acetate, terpinyl acetate, phenyl acetate Ethyl, butyl acetate, benzyl acetate, menthyl acetate, linalyl acetate, butyric acid, ethyl butyrate, butyl butyrate, isoamyl butyrate, cyclohexyl butyrate, 2-methylpropanal, 2-methylbutyraldehyde, 3-methyl-2-butenal 3-methyl Butanal, l-perylaldehyde, acetaldehyde, ethyl acetoacetate, isoamyl acetate, isoamyl butyrate, isovaleraldehyde, isobutanal, isopropyl acetate, isopropyl myristate, isovalose , Ethyl isovalerate, ethyl lactate, ethyl heptanoate, octanal, octanoic acid, ethyl octanoate, octylaldehyde, formic acid, isoamyl formate, geranyl formate, citronellyl formate, cinnamaldehyde, ethyl cinnamate, methyl cinnamate , Citral, citronellal, diisopropyl ether, diisopropyl disulfide, diisopropyl disulfide, diethyl ether, diethyl tartrate, diethyl pyrocarbonate, decanal, ethyl decanoate, triacetin, triethyl citrate, toluene, nonalactone, valeraldehyde, paramethylacetophenone, Paramethoxybenzaldehyde, castor oil, isoamyl phenylacetate, isobutyl phenylacetate, ethyl phenylacetate, butanal, propionaldehyde Propionic acid, isoamyl propionate, ethyl propionate, benzyl propionate, hexane, heptane, benzaldehyde, eucalyptol, ionone, terpinyl acetate, α-amylcinnamaldehyde, brominated vegetable oil, acetic acid, dimethyl dicarbonate, ethyl lactate, heat Preference is given to oxidized soybean oil, esters of glycerin with thermally oxidized soybean oil, or liquid paraffin.
As a solvent other than alcohol, water is particularly preferable.

In the composition of the present invention, the content of the solvent (when a plurality of types are present, the total thereof) is preferably 0.5 to 99.9% by mass, and preferably 10 to 99.8% by mass based on the total mass of the composition. %, More preferably 50 to 99.8% by mass, and particularly preferably 80 to 99.8% by mass.

When the composition of the present invention contains an alcohol, the content of the alcohol (in the case where a plurality of types are present, the total thereof) is, for example, 30% by mass or more based on the total mass of the solvent, in that the antiviral activity is more excellent. 40 mass% or more is preferable, and 60 mass% or more is more preferable. The upper limit of the alcohol content is not particularly limited, but is, for example, 100% by mass or less, and preferably 80% by mass or less, based on the total mass of the solvent.
Among them, when ethanol is contained as a solvent, the content of ethanol is preferably 80% by mass or less, more preferably less than 60% by mass, and more preferably 40% by mass or less, based on the total mass of the solvent, from the viewpoint of handleability. More preferred.

When the composition of the present invention contains an alcohol (particularly, ethanol) and the content of the alcohol is less than 60% by mass (preferably 40% by mass or less) based on the total mass of the solvent, the inorganic particles described above are used. By reducing the average particle size of (1) and / or the inorganic particles (2), the antiviral activity of the composition can be improved. Specifically, for example, when the inorganic particles (1) contain copper as the first metal and the inorganic particles (2) contain silver as the second metal, the average particle size of the inorganic particles (1) Is preferably 0.5 μm or less, more preferably 0.2 μm or less, from the viewpoint of better antiviral activity.

(PH of the composition)
The composition of the present invention has a pH of 9.0 to 13.5. When the pH is less than 9.0, the antiviral activity may be poor. On the other hand, the upper limit of the pH is preferably 11.5 or less from the viewpoint that the corrosiveness of the composition to metals can be further suppressed. The pH is preferably 10.0 or more from the viewpoint of more excellent antiviral properties.
The pH of the above composition is preferably 10.0 to 11.5 from the viewpoint of achieving both better antiviral activity and corrosiveness to metals.
The pH can be measured using a tabletop pH meter “F-72S” (manufactured by Horiba, Ltd.) using a pH electrode “6337-10D” (manufactured by Horiba, Ltd.). The specific measuring method is as described later.
In addition, in this specification, pH intends the value in 25 degreeC.

(Optional components)
The composition of the present invention may include components other than the above as long as the effects of the present invention are exhibited. The optional component is not particularly limited, but includes, for example, a surfactant, a disinfectant, a disinfectant, a disinfectant, an antioxidant, a pH adjuster, an ultraviolet absorber, a chelating agent, a humectant, a thickener and a gelling agent. , Preservatives, fragrances, dyes and the like. The composition of the present invention preferably contains a surfactant, a bactericide, a disinfectant, a disinfectant, or an antioxidant, in that the antiviral activity is more excellent, and a surfactant, a quaternary ammonium It is more preferable to include a salt (eg, benzalkonium chloride or the like) or an antioxidant, and even more preferable to include a surfactant or a quaternary ammonium salt (eg, benzalkonium chloride or the like).

<Surfactant and emulsifier>
The composition of the present invention preferably contains a surfactant and / or an emulsifier. When the base fabric is impregnated with the composition of the present invention containing a surfactant and / or an emulsifier and used as a wiper, less wiping residue is obtained, and detergency is more excellent.
The surfactant and the emulsifier are not particularly limited. For example, ionic surfactants such as anionic surfactants and cationic surfactants (however, ionic surfactants such as quaternary ammonium salts Is not included), and a nonionic surfactant.

Examples of the ionic surfactant include alkyl sulfates (such as sodium dodecyl sulfate), alkyl benzene sulfonates (such as sodium dodecyl benzene sulfonate), alkyl phosphates, and cholate salts (sodium deoxycholate and sodium lithocholic acid). , And sodium cholate); cationic surfactants such as alkyldiaminoethylglycine hydrochloride;

As the nonionic surfactant, a compound having a carbon number of more than 20 is preferable, for example, mono-, di- or polyglycerin fatty acid esters, propylene glycol fatty acid monoester, sorbitan fatty acid ester, sucrose fatty acid ester and the like. Ester type; polyoxyethylene alkyl ether, polyalkylene alkyl ether, and ether type such as polyoxyethylene polyoxypropylene glycol (manufactured by Kao Corporation, Emulgen series, etc.); fatty acid polyethylene glycol, fatty acid polyoxyethylene sorbitan, etc. Ester ether type; alkanolamide type such as fatty acid alkanolamide and the like.
Specific examples of the nonionic surfactant include, for example, polyethylene glycol monolauryl ether, polyethylene glycol monostearyl ether, polyethylene glycol monocetyl ether, polyethylene glycol monolauryl ester, and polyethylene glycol monostearyl ester.

The emulsifier is not particularly limited, but a nonionic emulsifier preferably has more than 20 carbon atoms. Specific examples of the emulsifier include oleic acid salts (the salt forms include calcium salts, sodium salts, and potassium salts), and caprate salts (the salt forms include calcium salts, sodium salts, and Potassium salts), caprylate (salts include calcium, sodium and potassium salts), laurate (salts include calcium, sodium and Potassium rosin), gum rosin glycerin ester, sodium starch octenylsuccinate, stearyl citrate, monoglyceride citrate, lactic acid and fatty acid esters of glycerin, fatty acid esters of mono-, di- or polyglycerin, stearic acid Salts (Salt forms include calcium salts, magnesium salts, Monium salts, aluminum salts, potassium salts, and sodium salts), myristates (in the form of salts, calcium salts, magnesium salts, ammonium salts, aluminum salts, potassium salts, and sodium salts). ), Palmitate (the salt forms include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt), calcium stearoyl lactate, sodium stearoyl lactate, sorbitan fatty acid ester, sulfosuccinic acid Dioctyl sodium, lecithin, hydroxylated lecithin, partially hydrolyzed lecithin, sunflower lecithin, enzymatically treated lecithin, propylene glycol fatty acid ester, polyoxyethylene sorbitan monolaurate, polyoxye monostearate Rensorbitan, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan oleate, quilla extract, vegetable sterols, sphingolipids, soy saponin, bile powder, animal sterols, fractionated lecithin, yucca foam extract, egg yolk lecithin, Tall oil, and rosin glycerin ester.

Among the above surfactants and emulsifiers, among others, food additives are preferred from the viewpoint of safety, and cholates (the salt forms include calcium salts, sodium salts, and potassium salts). , Deoxycholate (the salt forms include calcium, sodium and potassium salts), and oleate (the salt forms include calcium, sodium and potassium salts). ), Caprate (salt forms include calcium, sodium and potassium salts), caprylate (salt forms include calcium, sodium and potassium salts). ), Laurate (calcium salt, sodium salt, and potassium salt may be mentioned as salt forms), gum rosin glyce Ester, sodium starch octenylsuccinate, triethyl citrate, stearyl citrate, monoglyceride citrate, lactic acid and fatty acid esters of glycerin, fatty acid esters of mono-, di- or polyglycerin, fatty acid esters of sucrose, stearate (Salt forms include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt.), Myristate (as salt forms, calcium salt, magnesium salt, ammonium salt, Aluminum salt, potassium salt, and sodium salt), palmitate (salt forms include calcium, magnesium, ammonium, aluminum, potassium, and sodium salts), stearoy Calcium lactate, sodium stearoyl lactate, sorbitan fatty acid ester, dioctyl sodium sulfosuccinate, lecithin, hydroxylated lecithin, partially hydrolyzed lecithin, sunflower lecithin, enzyme-treated lecithin, propylene glycol fatty acid ester, polyoxyethylene sorbitan monolaurate, polyoxymonostearate Ethylene sorbitan, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan oleate, quilla extract, vegetable sterol, sphingolipid, soy saponin, bile powder, animal sterol, fractionated lecithin, yucca foam extract, egg yolk lecithin, Tall oil or rosin glycerin ester is preferred.

The surfactant and the emulsifier may be used alone or in a combination of two or more.
When the composition of the present invention contains a surfactant and / or an emulsifier, the content of the surfactant and the emulsifier (when there are plural kinds thereof, the total thereof) is 0.01 to 0.01% based on the total mass of the composition. It is preferably 2% by mass, more preferably 0.05 to 2% by mass, and still more preferably 0.05 to 1% by mass.

<Disinfectant, disinfectant, and disinfectant>
The disinfectant, disinfectant, and disinfectant are not particularly limited, and include, for example, quaternary ammonium salts, photocatalysts, aldehyde compounds, iodine compounds, piguanide compounds, and acrynol hydrate (eg, lactic acid 6,9- Diamino-2-ethoxyacridine monohydrate) and the like. Among them, a quaternary ammonium salt is preferable because the antiviral activity is more excellent when combined with the composition of the present invention.

(Quaternary ammonium salt)
The quaternary ammonium salt is not particularly limited, and includes, for example, compounds represented by the following formulas (2) to (5).

In the formula (2), R ²¹ to R ²⁴ each independently represent an aliphatic hydrocarbon group, an aryl group, an aralkyl group, or a heteroaryl group.
The aliphatic hydrocarbon group represented by R ²¹ to R ²⁴ may be linear, branched, or cyclic.
Further, the aliphatic hydrocarbon group represented by R ²¹ to R ²⁴ may contain a hetero atom. The type of the hetero atom is not particularly limited, and examples thereof include an oxygen atom, a nitrogen atom, a sulfur atom, a selenium atom, and a tellurium atom. Among them, in terms of antiviral activity more ^{excellent, -Y 1 -, - N (} Ra) -, - C (= Y 2) -, - CON (Rb) -, - C (= Y 3) Y 4 - , —SOt—, —SO ₂ N (Rc) —, or a combination thereof.
Y ¹ to Y ⁴ are each independently selected from the group consisting of an oxygen atom, a sulfur atom, a selenium atom, and a tellurium atom. Among them, an oxygen atom or a sulfur atom is preferable in terms of easier handling. t represents an integer of 1 to 3. Ra, Rb, and Rc each independently represent a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.
When the aliphatic hydrocarbon group contains a hetero atom, -CH ₂ -is substituted with a hetero atom.

Specific examples of the aliphatic hydrocarbon group represented by R ²¹ to R ²⁴ include an alkyl group (preferably having 1 to 30 carbon atoms, more preferably 1 to 20 carbon atoms) and an alkenyl group (having 2 to carbon atoms). 30 is preferable, and C2 to C20 is more preferable), or an alkynyl group (C2 to C30 is preferable, and C2 to C20 is more preferable). Among them, an alkyl group is preferable.

The aryl group represented by R ²¹ to R ²⁴ is not particularly limited, and is, for example, preferably an aryl group having 6 to 18 carbon atoms, and specific examples include a phenyl group and a naphthyl group.

The aralkyl group represented by R ²¹ to R ²⁴ is not particularly limited, but is preferably, for example, an aralkyl group having 7 to 15 carbon atoms, specifically, a benzyl group, a phenethyl group, a 1-naphthylmethyl group, Examples thereof include a (1-naphthyl) ethyl group, a triphenylmethyl group, and a pyrenylmethyl group.

As the heteroaryl group represented by R ²¹ to R ²⁴ , for example, a heteroaryl group having 3 to 12 carbon atoms is preferable. For example, a furyl group, a thiofuryl group, a pyridyl group, a pyrazole group, an imidazolyl group, a benzimidazolyl group, an indolyl And quinolyl, isoquinolyl, purine, pyrimidyl, pyrazyl, oxazolyl, thiazolyl, triazyl, carbazolyl, quinoxalyl, and thiazine groups.

The aliphatic hydrocarbon group, aryl group, aralkyl group, and heteroaryl group represented by R ²¹ to R ²⁴ may further have a substituent. Examples of the substituent include those exemplified in the substituent group W described above.

X ⁻ represents a monovalent anion other than a hydroxide ion.
As X ⁻ , specifically, halide ions (eg, F ⁻ , Cl ⁻ , Br ⁻ , I ⁻ , Br ₃ ⁻ , Br ₂ Cl ⁻ , I ₃ ⁻ , IBr ₂ ⁻ , Cl ₂ Br ⁻ , HF ₂ ⁻ , H ₂ F ₃ ⁻ , AuBr ₂ ⁻ , AuCl ₂ ⁻ , AuI ₂ ⁻ and FeCl ₄ ⁻ ), carboxylate anion, cyanide anion, sulfonimide anion (N ⁻ (SO ₂ R ) ₂ : R is a fluorine atom, a hydrocarbon group (eg, an alkyl group having 1 to 20 carbon atoms), or a perfluorohydrocarbon group (eg, a perfluoroalkyl group having 1 to 20 carbon atoms). ), Borohydride anion, dichloroiodate anion, tetrafluoroborate anion, hexafluorophosphate anion, perchlorate anion, sulfuric acid On hydrogen anionic sulfate, nitrate anions, dicyanamide anion _{^{[N - (CN) 2]}} , azide anion (N ₃ ^-), alkane or arylsulfonic acid anion, perfluoro alkane or arylsulfonic acid anion, an alkyl or aryl acid Ester anion (ROSO ₃ ⁻ : R represents an alkyl group having 1 to 20 carbon atoms or an aryl group having 6 to 18 carbon atoms), an alkyl or aryl phosphate anion ((RO) ₂ PO ₂ ⁻ : R Each independently represents an alkyl group having 1 to 20 carbon atoms or an aryl group having 6 to 18 carbon atoms.), Thiocyanide anion (S ⁻ CN), triacetoxyborohydride anion, perruthenate anion (RuO _{4) ^{-), Cu (CF 3)}} 4 -, C (CN) 3 -, and CF ₃ BF ₃ ^- include

The compound represented by the formula (2) is illustrated below, but the invention is not limited thereto.

In the formula (3), X ^- is, X in the formula (2) ^- has the same meaning as, preferred embodiments are also the same.
R ³¹ and R ³² have the same meanings as R ²¹ to R ^{24 in} formula (2), and the preferred embodiments are also the same.
Y ³¹ and Y ³² are each _{^{independently, -C (R 33) 2 -}} , - NR 34 -, - O -, - CO -, - CO 2 -, - S -, - SO-, or -SO ₂ Represents-. In the formula (2), if Y ³² is plural, Y ³² is may be the same or different.
R ³³ represents a hydrogen atom or a monovalent organic group selected from the group consisting of an aliphatic hydrocarbon group, an aryl group, an aralkyl group, a heteroaryl group, and a halogen atom.
R ³⁴ represents a hydrogen atom or a monovalent organic group selected from the group consisting of an aliphatic hydrocarbon group, an aryl group, an aralkyl group, and a heteroaryl group.
The aliphatic hydrocarbon group, aryl group, aralkyl group and heteroaryl group represented by R ³³ and R ³⁴ are the aliphatic hydrocarbon group and aryl group represented by R ²¹ to R ²⁴ in the formula (2). , An aralkyl group, or a heteroaryl group, and the preferred embodiments are also the same.
Examples of the halogen atom represented by R ³³ and R ³⁴ include a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom.

The aliphatic hydrocarbon group, aryl group, aralkyl group, or heteroaryl group represented by R ³³ and R ³⁴ may further have a substituent. Examples of the substituent include those exemplified in the substituent group W described above.

When Y ³¹ or Y ³² represents —C (R ³³ ) ₂ — or —NR ³⁴ —, the monovalent organic group represented by R ³¹ is linked to R ³³ or R ³⁴ and It may form an aromatic or non-aromatic ring.
R ³¹ and R ³² may be linked to each other to form an aromatic or non-aromatic ring.
n represents an integer of 1 to 18.

The compound represented by the formula (3) is illustrated below, but the invention is not limited thereto.

In the formula (4), X ^- is, X in the formula (2) ^- has the same meaning as, preferred embodiments are also the same.
R ⁴¹ has the same meaning as R ²¹ to R ^{24 in} formula (2), and the preferred embodiments are also the same.
Y ⁴¹ to Y ⁴⁵ each independently represent a nitrogen atom or ＣＲCR ⁴² —. R ⁴² represents a hydrogen atom or a monovalent substituent.
The monovalent substituent represented by R ⁴² is not particularly limited, and examples thereof include those exemplified in the substituent group W described above.
When two or more of Y ⁴¹ to Y ⁴⁵ represent ＣＲCR ⁴² —, R ⁴² substituted for adjacent carbon atoms are connected to each other to form an aromatic or non-aromatic ring. You may.
When Y ⁴¹ to Y ⁴⁵ represent 表^す CR ⁴² —, the monovalent substituent represented by R ⁴² is linked to R ⁴¹ to form an aromatic or non-aromatic ring. Is also good.

The compound represented by the formula (4) is illustrated below, but the present invention is not limited thereto.

In the formula (5), X ^- is, X in the formula (2) ^- has the same meaning as, preferred embodiments are also the same.
Y ⁵¹ to Y ⁵³ have the same meanings as Y ⁴¹ to Y ^{45 in} the formula (4), and the preferred embodiments are also the same.
Y ⁵⁴ represents> NR ⁵¹ , a sulfur atom, or an oxygen atom.
R ⁵¹ and R ⁵² have the same meanings as R ²¹ to R ^{24 in} formula (2), and the preferred embodiments are also the same.

化合物 Examples of the compound represented by the formula (5) are shown below, but the invention is not limited thereto.

(photocatalyst)
The photocatalyst, if a substance to exhibit a photocatalytic activity are known not particularly limited, for _{example, TiO 2, SrTiO 2, ZnO} , CdS, SnO 2, and WO _3, and the like.

(Aldehyde compound)
The aldehyde compound is not particularly limited, and examples thereof include glutaral, phthalal, and formalin.

(Iodine compound)
The iodine-based compound is not particularly limited, and examples thereof include povidone-iodine and tincture of iodine.

(Piguanide compound)
Although there is no particular limitation on the piguanide compound, examples thereof include chlorhexidine gluconate, chlorhexidine hydrochloride, and chlorhexidine acetate.

The disinfectant, disinfectant and disinfectant may be used alone or in combination of two or more.
When the composition of the present invention contains a disinfectant, a disinfectant, and / or a disinfectant, the content of the disinfectant, disinfectant, and disinfectant (when there are a plurality of kinds, the total thereof) of the composition is The content is preferably 0.001 to 10% by mass, more preferably 0.01 to 3% by mass, and still more preferably 0.01 to 1% by mass based on the total mass.

<Antioxidant>
The composition of the present invention preferably contains an antioxidant. When the composition of the present invention contains an antioxidant, the antiviral activity is more excellent.
The antioxidant is not particularly limited, and examples thereof include “Theory and Practice of Antioxidants” (Kajimoto, Sanshobo 1984) and “Antioxidant Handbook” (Saruwatari, Nishino, Tabata, Taiseisha 1976). The various antioxidants described can be used.

防止 Examples of the antioxidant include ascorbic acid, ascorbic acid derivatives, and salts thereof; erythorbic acid, erythorbic acid derivatives, and salts thereof; compounds having a phenolic hydroxyl group; and amine compounds such as phenylenediamine.

Examples of the above ascorbic acid, ascorbic acid derivative, and salts thereof include L-ascorbic acid, sodium L-ascorbate, potassium L-ascorbate, calcium L-ascorbate, L-ascorbic acid phosphate, and L-ascorbic acid phosphate. Magnesium salt of ascorbic acid phosphate, L-ascorbic acid sulfate, disodium L-ascorbic acid sulfate, L-ascorbic acid stearic acid ester, L-ascorbic acid 2-glucoside, L-ascorbic acid palmitic acid ester, And L-ascorbyl tetraisopalmitate.

Examples of the erythorbic acid, erythorbic acid derivatives, and salts thereof include erythorbic acid, sodium erysorbate, potassium erysorbate, calcium erysorbate, erythorbic acid phosphate, and erythorbic acid sulfate.

Examples of the compound having a phenolic hydroxyl group include polyphenols (for example, catechin contained in tea extract), nordihydroguaiaretic acid (NDGA), and gallic esters (for example, propyl gallate, butyl gallate, and the like). Octyl gallate, BHT (dibutylhydroxytoluene), BHA (butylhydroxyanisole), carcinonic acids (rosemary extract, etc.), ferulic acid, vitamin Es, bisphenols, and the like.
Examples of the vitamin Es include tocopherol (vitamin E) and its derivatives, and tocotrienol and its derivatives.
Examples of the tocopherol and its derivatives include dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol, dl-δ-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, Examples include linoleic acid-dl-α-tocopherol, dl-α-tocopherol succinate, and acetates thereof.
Examples of the tocotrienol and derivatives thereof include α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, and acetates thereof.

ア ミ ン Examples of the amine compound include phenylenediamine, diphenyl-p-phenylenediamine, and 4-amino-p-diphenylamine.

Among the above antioxidants, food additives are preferable from the viewpoint of safety. 4-hexylresorcin, BHT, butylhydroxyanisole, calcium disodium ethylenediaminetetraacetate, L-ascorbic acid, L-ascorbic acid Calcium acid, L-ascorbic acid stearate, sodium L-ascorbate, L-ascorbic acid palmitate, tert-butylhydroquinone, d-α-tocopherol concentrate, dl-α-tocopherol, anoxomer, isoascorbic acid, Erysorbic acid, sodium erysorbate, isopropyl citrate, guaiac butter, guaiac resin, dilauryl thiodipropionate, thiodipropionic acid, distearyl thiodipropionate, sodium thiosulfate M, nordihydroguaretic acid, potassium pyrosulfite, sodium pyrosulfite, ethyl protocatechuate, ferulic acid, propyl gallate, isoamyl gallate, dodecyl gallate, potassium sulfite, sodium sulfite, potassium bisulfite, sodium bisulfite, Alternatively, stannous chloride is preferred.

Antioxidants may be used alone or in combination of two or more.
When the composition of the present invention contains an antioxidant, the content of the antioxidant (when there are plural kinds thereof, the total thereof) is preferably from 0.001 to 2% by mass relative to the total mass of the composition. The content is more preferably from 0.01 to 1% by mass, and still more preferably from 0.01 to 0.5% by mass.

<PH adjuster>
The pH adjuster is not particularly limited, but includes metal alkoxides (eg, sodium methoxide, sodium ethoxide, etc.), metal oxides (eg, calcium oxide, magnesium oxide, etc.), hydrogen carbonates (ammonium hydrogen carbonate, carbonate Sodium hydrogen, potassium hydrogen carbonate, calcium hydrogen carbonate, etc.), metal hydroxides (calcium hydroxide, magnesium hydroxide, potassium hydroxide, sodium hydroxide, lithium hydroxide, aluminum hydroxide, rubidium hydroxide, cesium hydroxide) , Strontium hydroxide, barium hydroxide, europylium (II) hydroxide and thallium (I) hydroxide, etc.), carbonates (ammonium carbonate, potassium carbonate, calcium carbonate, sodium carbonate, magnesium carbonate, cesium carbonate, etc.), Quaternary ammonium hydroxide Organic bases (guanidine derivatives, diazabicycloundecene, and diazabicyclononene, etc.), phosphazene base, and pro-aza phosphatonin Tran bases, and the like.
As the pH adjuster, those used as food additives from the viewpoint of safety are preferable, and sodium methoxide, calcium oxide, magnesium oxide, ammonium bicarbonate, sodium bicarbonate, potassium bicarbonate, calcium bicarbonate, Calcium, magnesium hydroxide, potassium hydroxide, sodium hydroxide, ammonium carbonate, potassium carbonate, calcium carbonate, sodium carbonate, or magnesium carbonate is preferred.

The pH adjusters may be used alone or in combination of two or more.
When the composition of the present invention contains a pH adjuster, the content of the pH adjuster (when there are a plurality of types, the total thereof) is appropriately changed depending on the content of the specific compound and the like, and thus cannot be limited. The pH is preferably from 0.001 to 30% by mass, more preferably from 0.005 to 20% by mass, and preferably from 0.01 to 10% by mass, based on the total mass of the composition, so that the pH of the composition exceeds 9.5. % Is more preferred.

<Ultraviolet absorber>
The ultraviolet absorber is not particularly limited. For example, salicylic acid-based compounds such as homomenthyl salicylate, octyl salicylate, and triethanolamine salicylate; paraaminobenzoic acid, ethyldihydroxypropylparaaminobenzoic acid, glycerylparaaminobenzoic acid, and octyldimethylparaaminobenzoic acid Para-aminobenzoic acid-based compounds such as amyl para-dimethylaminobenzoate and 2-ethylhexyl para-dimethylaminobenzoate; 4- (2-β-glucopyranosyloxy) propoxy-2-hydroxybenzophenone, dihydroxydimethoxybenzophenone, Sodium dihydroxydimethoxybenzophenone disulfonate, 2-hydroxy-4-methoxybenzophenone, and hydroxymethoxybenzophenone sulfonic acid; Trihydrate, sodium hydroxymethoxybenzophenonesulfonate, 2-hydroxy-4-methoxybenzophenone-5-sulfate, 2,2′-dihydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 2,2′4 Benzophenone-based compounds such as 4'-tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone and 2-hydroxy-4-N-octoxybenzophenone; 2-ethylhexyl paramethoxycinnamate (also known as Octyl paramethoxycinnamate), glyceryl mono-2-ethylhexanoate diparamethoxycinnamate, methyl 2,5-diisopropylcinnamate, 2,4,6-tris [4- (2-ethylhexyl) Oxycarbonyl) anilino] -1,3,5-triazine, Cinnamic compounds such as methylbis (trimethylsiloxy) silyl isopentyl methoxycinnamate, a mixture of isopropyl para-methoxycinnamate and diisopropylcinnamate, and diethanolamine p-methoxyhydrocinnamate; 2-phenyl-benz Benzoylmethane compounds such as imidazole-5-sulfate, 4-isopropyldibenzoylmethane and 4-tert-butyl-4'-methoxydibenzoylmethane; 2-cyano-3,3-diphenylprop-2-enoic acid- 2-ethylhexyl ester (also known as octocrylene), 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidine propionate, 1- (3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, sinoxate, Methyl-OA Nobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenylacrylate, 3- (4-methylbenzylidene) camphor, octyltriazone, 4- (3,4-dimethoxyphenylmethylene) -2,5-dioxo- 2-ethylhexyl 1-imidazolidinepropionate, polymer derivatives thereof, and silane derivatives.

The ultraviolet absorbers may be used alone or in combination of two or more.
When the composition of the present invention contains an ultraviolet absorber, the content of the ultraviolet absorber (when a plurality of types are present, the total thereof) is preferably 0.001 to 3% by mass based on the total mass of the composition. The content is more preferably 0.001 to 2% by mass, and still more preferably 0.001 to 1% by mass.

<Chelating agent>
The chelating agent is not particularly restricted but includes, for example, aminopolycarboxylic acid chelating agents, aromatic or aliphatic carboxylic acid chelating agents, amino acid chelating agents, phosphonic acid chelating agents, phosphoric acid chelating agents, hydroxycarboxylic acids Chelating agents, polymer electrolyte (including oligomer electrolyte) chelating agents, dimethylglyoxime, thioglycolic acid, phytic acid, glyoxylic acid, glyoxalic acid, and the like. Each of these chelating agents may be in a free acid form or in a salt form such as a sodium salt, a potassium salt, and an ammonium salt.

Examples of the aminopolycarboxylic acid chelating agent include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, and N- (2 -Hydroxyethyl) ethylenediaminetriacetic acid, glycoletherdiaminetetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid, and salts thereof.

Examples of the aromatic or aliphatic carboxylic acid chelating agent include, for example, oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvic acid, salicylic acid, Examples include acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranilic acid), phthalic acid, fumaric acid, trimellitic acid, gallic acid, hexahydrophthalic acid, and salts thereof.

Examples of the amino acid chelating agent include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts thereof.

{Examples of phosphonic acid-based chelating agents include, for example, iminodimethylphosphonic acid, alkyl diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, and salts thereof.

(4) Examples of the phosphoric acid chelating agent include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid, and polyphosphoric acid.

Examples of the hydroxycarboxylic acid-based chelating agent include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartaric acid, lactic acid, and salts thereof.

Examples of the polymer electrolyte (including oligomer electrolyte) chelating agent include acrylic acid polymer, maleic anhydride polymer, α-hydroxyacrylic acid polymer, itaconic acid polymer, and monomer 2 of these polymers. Copolymers of at least one species, epoxy succinic acid polymers, and the like.

One chelating agent may be used alone, or two or more chelating agents may be used in combination.
When the composition of the present invention contains a chelating agent, the content of the chelating agent (when there are plural kinds thereof, the total thereof) is preferably from 0.001 to 3% by mass relative to the total mass of the composition. 001 to 2% by mass is more preferable, and 0.001 to 1% by mass is more preferable.

<Moisturizer>
The humectant is not particularly limited, for example, deoxyribonucleic acid, mucopolysaccharide, hyaluronic acid, chondroitin sulfate, aloe extract, gelatin, elastin, chitin, chitosan, hydrolyzed eggshell membrane, polyoxyethylene methyl glucoside, polyoxypropylene methyl Examples include glucoside, sodium lactate, urea, sodium pyrrolidonecarboxylate, betaine, and whey.

One type of humectant may be used alone, or two or more types may be used in combination.
When the composition of the present invention contains a humectant, the content of the humectant (when a plurality of kinds are present, the total thereof) is preferably 0.001 to 3% by mass relative to the total mass of the composition. 001 to 2% by mass is more preferable, and 0.001 to 1% by mass is more preferable.

<Thickener and gelling agent>
Examples of the thickener and gelling agent include, for example, maleic anhydride / methyl vinyl ether copolymer, dimethyldiallylammonium chloride / acrylamide copolymer, acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer, cellulose or a derivative thereof, Keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, oat gum, acacia gum, crystalline cellulose, arabinogalactan, Karaya gum, tragacanth gum, carob bean gum, gati gum, alginic acid and its salts (ammonium, potassium, calcium and sodium salts are listed as salts). Propylene glycol alginate, albumin, casein, curdlan, β-glucan and β-glucan derivatives, locust bean gum, gellan gum, cassia gum, mannan, tara gum, tragacanth gum, tamarind gum, dextran, polydextrose, α-glucose, ethyl Hydroxyethylcellulose, carboxymethylcellulose and salts thereof (the salt forms include calcium salts and sodium salts), sodium carboxymethylcellulose enzymatically decomposed, hydroxypropylcellulose, hydroxypropylstarch, hydroxypropylmethylcellulose, methylethylcellulose, methylcellulose, Hydroxypropylated epi-crosslinked starch, hydroxypropylated phosphoric acid crosslinked starch Amylopectin, hydroxypropylated phosphate crosslinked starch, acetylated adipic acid crosslinked starch, oxidized hydroxypropylated epicrosslinked starch, acetylated phosphate crosslinked starch, acetylated oxidized starch, alkali-treated starch, hydroxypropylated epicrosslinked starch, glycerol Crosslinked starch, acid-treated starch, phosphoric acid monoesterified phosphoric acid crosslinked starch, phosphorylated starch, starch acetate, bleached starch, enzyme-treated starch, oxidized starch, sodium starch glycolate, sodium starch succinate, glucomannan, cyclodextrin, Examples include dextrin, pullulan, pectin, sodium polyacrylate, Eukema, β-1,3-glucan agar, and α-glucose derivatives.

The thickener and the gelling agent may be used alone or in combination of two or more.
When the composition of the present invention contains a thickening agent and / or a gelling agent, the content of the thickening agent and the gelling agent (when there are plural kinds thereof, the total thereof) is based on the total mass of the composition. The content is preferably 0.001 to 3% by mass, more preferably 0.001 to 2% by mass, and still more preferably 0.001 to 1% by mass.

<Preservative>
The preservative is not particularly limited. For example, benzoic acid, sodium benzoate, potassium sorbate, sodium sorbate, sorbic acid, sodium dehydroacetate, hydrogen peroxide, formic acid, ethyl formate, sodium dichlorite, propionic acid , Sodium propionate, calcium propionate, pectin degradation products, polylysine, phenoxyethanol, thiram, thiabendazole, imazalil, diphenyl, natamycin, fludioxonil, azoxystrobin, and tea tree oil.

The preservatives may be used alone or in combination of two or more.
When the composition of the present invention contains a preservative, the content of the preservative (when a plurality of kinds are present, the total thereof) is preferably 0.001 to 3% by mass relative to the total mass of the composition. 001 to 2% by mass is more preferable, and 0.001 to 1% by mass is more preferable.

<Fragrance>
The flavor is not particularly limited, for example, musk, acacia oil, anise oil, ylang-ylang oil, jasmine oil, sweet orange oil, spearmint oil, geranium oil, neroli oil, peppermint oil, hinoki oil, fennel oil, peppermint oil, Bergamot oil, lime oil, lavender oil, lemon oil, lemongrass oil, rose oil, rosewood oil, anisaldehyde, civetone, muscone, limonene and the like.

The flavors may be used alone or in combination of two or more.
When the composition of the present invention contains a fragrance, the content of the fragrance (when a plurality of kinds are present, the total thereof) is preferably 0.001 to 3% by mass, and more preferably 0.001 to 3% by mass based on the total mass of the composition. The content is more preferably 2% by mass, and further preferably 0.001 to 1% by mass.

<Dye>
The pigment is not particularly limited, but examples include krill pigment, orange pigment, kaolin, gunjo, chromium oxide, iron oxide, titanium dioxide, chlorophyll, and the like.

One type of dye may be used alone, or two or more types may be used in combination.
When the composition of the present invention contains a colorant, the content of the fragrance (when there are plural types, the total thereof) is preferably 0.001 to 3% by mass, and more preferably 0.001 to 3% by mass based on the total mass of the composition. The content is more preferably 2% by mass, and further preferably 0.001 to 1% by mass.

(Production method of the composition)
The composition of the present invention can be prepared by appropriately mixing the above-mentioned essential components and optional components. The order of mixing the above components is not particularly limited.

(Formulation)
The dosage form of the composition of the present invention is not particularly limited, and examples thereof include a liquid preparation, a gel preparation, an aerosol spray preparation, and a non-aerosol spray preparation.

[Application]
The composition of the present invention is preferably used as an antiviral composition, and has, for example, an activity of inactivating viruses belonging to the Caliciviridae family, the Orthomyxoviridae family, the Coronaviridae family, and the Herpesviridae family. Therefore, it is preferable to use the above-mentioned virus to reduce the activity of the virus by acting on the virus. Examples of the virus belonging to the Caliciviridae include viruses belonging to the genera Norovirus, Sapovirus, Lagovirus, Nebovirus, and Vesivirus. The composition of the present invention exerts a good inactivation effect on viruses belonging to the genus Norovirus and viruses belonging to the genus Vesivirus.
Further, the composition of the present invention is useful for microorganisms such as bacteria and fungi (particularly microorganisms that produce an enzyme (uretase) that degrades urea, such as Proteus (eg, P. mirabilis, P. vulgaris). Demonstrate a good inactivation effect.

The composition is preferably used as an anti-norovirus composition.
The method of using the above composition is not particularly limited, but the composition can be applied to a portion where the norovirus adheres or is likely to adhere, or can be applied in advance. The method of applying the composition is not particularly limited, but, for example, a method of spraying the composition to the location, a method of wiping the location with a base cloth containing the composition, and a method of applying a finger with a composition that is a liquid cleaning agent. A washing method and the like can be mentioned.

[spray]
The spray of the present invention includes a spray container and an antiviral composition contained in the spray container. The antiviral composition is as described above.
The spray container may be an aerosol spray container or a non-aerosol spray container. As the spray container, a non-aerosol spray container is particularly preferable.
The case where the spray container is an aerosol spray container means, for example, a form in which the spray container contains a gas such as a liquid gas and a compressed gas in addition to the antiviral composition. The aerosol spray container specifically includes a spray container containing a gas such as liquefied petroleum gas (LPG), dimethyl ether (DME), carbon dioxide gas, nitrogen gas, and isopentane.
The case where the spray container is a non-aerosol spray container means that the spray container does not substantially contain a gas such as a liquid gas and a compressed gas, and the liquid contained in the container is in a mist-like or foam-like form. It is intended to have a form provided with a mechanism for jetting out of the container. Examples of the non-aerosol spray container include a pressure-accumulation type spray container such as a pump type and a trigger type.

[Wiper]
The wiper of the present invention includes a base fabric and an antiviral composition impregnated in the base fabric.
The antiviral composition is as described above.
The base cloth is not particularly limited, and may be formed of natural fibers or chemical fibers.
Examples of the natural fiber include pulp, cotton, hemp, flax, wool, cashmere, cashmere, mohair, silk, and the like.
Examples of the chemical fiber include polyethylene terephthalate, rayon, polynosic, acetate, triacetate, nylon, polyester, polyacrylonitrile, polyvinyl alcohol, polyvinyl chloride, polyvinylidene chloride, polyethylene, polypropylene, polyurethane, polyalkylene paraoxybenzoate, and polyclar. Can be
Among these base fabrics, a hydrophilic base fabric is preferable because it is easy to impregnate the composition. The hydrophilic base cloth is, for example, a base cloth including fibers having a hydrophilic group such as a hydroxyl group, an amino group, a carboxy group, an amide group, and a sulfonyl group. Specific examples of the hydrophilic base fabric include vegetable fibers, cotton, pulp, animal fibers, rayon, nylon, polyester, polyacrylonitrile, and polyvinyl alcohol.
In addition, as the base fabric, nonwoven fabric, cloth, towel, gauze, absorbent cotton, and the like can be used, and nonwoven fabric is preferable.

Further, the basis weight (mass per unit area) of the base cloth is preferably 100 g / m ² or less. The amount of impregnation when impregnating the base fabric with the above composition is preferably at least one time the mass of the base fabric.

本 Hereinafter, the present invention will be described in more detail with reference to Examples. Materials, used amounts, ratios, processing contents, processing procedures, and the like shown in the following examples can be appropriately changed without departing from the spirit of the present invention. Therefore, the scope of the present invention should not be construed as being limited by the following examples.

[Preparation of composition]
Example 1 Preparation of Composition 1
Based on the composition of the components shown in Table 1, pure water and a copper-supported silicate glass (average particle size adjusted to 1.0 μm) were stirred while ethanol was stirred in a container (corresponding to inorganic particles (1). "NS-20C": a solid content concentration of 100% by mass), a silver-supported phosphate glass having an average particle diameter adjusted to 0.5 μm (corresponding to inorganic particles (2), "Bacterite" manufactured by Fuji Chemical Co., Ltd.) (Ethanol dilution: solid content concentration: 25% by mass), and a pH adjusting agent was added so that the pH of the composition after the preparation became 11.5 to obtain a composition. The pH was measured by the following method.

<Method of measuring pH>
pH standard using a pH meter (product name “pH / water quality analyzer LAQUA F-72S”, manufactured by HORIBA, Ltd.) and a pH electrode (product name “6377-10D”, manufactured by HORIBA, Ltd.) The measurement was performed after the pH was calibrated with the liquid. After the sample solution was adjusted to a liquid temperature of 25 ° C., the electrode was immersed in the sample solution, allowed to stand for about 1 to 2 minutes, and the pH value when the numerical value was stabilized was read.

[Preparation of Compositions of Examples 2 to 13 and Comparative Examples 1 to 8]
According to the preparation method of the composition of Example 1, the compositions of Examples 2 to 13 and Comparative Examples 1 to 8 were prepared with the components shown in Table 1 and the pH.

[Evaluation]
The prepared compositions of Examples 1 to 13 and Comparative Examples 1 to 8 were evaluated for antiviral activity by the following method. The evaluation of the antiviral activity was performed immediately after the preparation of the composition and at the time of storage for 6 months (stored at 25 ° C.).

(Evaluation of anti-cat calicivirus activity)
After inoculating a virus solution obtained by culturing feline calicivirus (ATCC VR-782) in a MEM (Minimum Essential Media) medium into the composition prepared above, the mixture was stirred for 10 seconds, and then stirred for about 25 seconds. The mixture was allowed to stand at ℃ for 1 minute. Next, 0.1 mL of the solution of the composition after the virus inoculation was recovered, and 9.9 mL of SCDLP medium (Soybean. Casein Digest Agar with Lecithin and Polysorbate 80, and serum were added to a final concentration of 10%. ) And mixed well to obtain a test solution. Next, 0.1 mL of the above test solution was inoculated into CRFK cells (cat kidney derived cell line, ATCC CCL-94) cultured on an agar medium, and allowed to adsorb at 37 ° C. for 1 hour. Next, the test solution on the CRFK cells was washed away, an agar medium was overlaid, and the cells were cultured for 2 to 3 days. After the culture, the number of plaques formed was counted, and the infectious titer was calculated. The infectivity was also calculated for a specimen prepared in the same manner as described above except that sterilized purified water was used instead of the composition, and this was defined as the “control infectivity”.
The antiviral property (antiviral activity value) of the composition was calculated using the following equation 1, and the calculation result was evaluated using the following criteria.
The compositions used for the evaluation were the compositions immediately after each preparation.

Formula 1: Antiviral activity value = AB
A represents the common logarithm of the infectivity titer of the control.
B represents the common logarithmic value of the infectious titer of the composition.

<Evaluation criteria>
"A": Antiviral activity value of 4.0 or more "B": Antiviral activity value of 3.5 or more and less than 4.0 "C": Antiviral activity value of 3.0 or more and less than 3.5 "D" : Antiviral activity value is 2.0 or more and less than 3.0 “E”: Antiviral activity value is less than 2.0

Table 1 is shown below.
In Table 1, the content (% by mass) of each component described in the column of the antiviral agent represents the content based on the total mass of the composition.
“Copper-supported silicate glass” in Table 1 is “NS-20C” (manufactured by Toagosei Co., Ltd.) (solid content concentration: 100% by mass), and corresponds to the inorganic particles (1). The copper-supported silicate glass was used after adjusting the average particle size.
"Silver-supported phosphate glass" in Table 1 is "Bacterite" (ethanol dilution: solid content concentration: 25% by mass) manufactured by Fuji Chemical Co., and corresponds to the inorganic particles (2). The silver-supported phosphate glass was used after adjusting the average particle size. The content (% by mass) of the “silver-supporting phosphate glass” described in the second antiviral component column is a solid content that does not include ethanol as a diluting solvent.
The “residual part” in the “solvent” column in Table 1 refers to the first antiviral component and the second antiviral component described in the antiviral component column based on the total composition (% by mass) of the antiviral composition. The content of each solid content of the virus component (% by mass) and the content of the pH adjuster (% by mass) are intended to be subtracted.

結果 From the results in Table 1, it was confirmed that the antiviral compositions of the examples exhibited excellent antiviral activity against feline calicivirus.

Also, it was confirmed that when the pH of the composition was 10.0 to 11.5, the antiviral activity against feline calicivirus could be improved (compared to Examples 1 to 3 and Comparative Examples 4 to 6).
In addition, the inorganic particles (1) containing copper as the first metal and the inorganic particles (2) containing silver as the second metal, and the average particle diameter of the inorganic particles (1) is 0.5 μm. In the following cases, it was confirmed that the antiviral activity against feline calicivirus could be further improved (Comparison between Example 7 and Examples 9 to 11).
When the composition contains copper-supported silicate glass as the inorganic particles (1) and silver-supported silicate glass as the inorganic particles (2), the antiviral activity against feline calicivirus can be further improved. It was confirmed (comparison between Example 2 and Example 13).
In addition, it was confirmed that when the composition contains alcohol as a solvent, the antiviral activity against feline calicivirus (after storage for 6 months) can be further improved (Examples 2, 5, 7, and 8). , And Example 12).

Also, from the results in Table 1, it was confirmed that the antiviral composition of Comparative Example did not exhibit the desired antiviral activity.

Claims (17)

1. An antiviral composition comprising inorganic particles and a solvent and having a pH of 9.0 to 13.5,
   An antiviral composition comprising, as the inorganic particles, inorganic particles containing a first metal and inorganic particles containing a second metal different from the first metal.
2. Inorganic particles containing the first metal, a metal-supported inorganic substance having a simple substance of the first metal, an oxide of the first metal, and an inorganic carrier and the first metal supported on the inorganic carrier. The antiviral composition according to claim 1, which is at least one member selected from the group consisting of a carrier.
3. Inorganic particles containing the second metal, the second metal alone, an oxide of the second metal, and a metal-supported inorganic having an inorganic carrier and the second metal supported on the inorganic carrier 3. The antiviral composition according to claim 1, which is at least one member selected from the group consisting of a carrier.
4. 4. The antiviral composition according to claim 2, wherein the inorganic carrier is glass.
5. The antiviral composition according to any one of claims 1 to 4, wherein the first metal is copper, and the second metal is silver.
6. The method according to any one of claims 1 to 5, wherein the inorganic particles containing the first metal are copper-supported silicate glass having silicate glass and copper supported on the silicate glass. The composition for antivirus according to the above.
7. The antiviral composition according to claim 6, wherein the inorganic particles containing the first metal have an average particle size of 0.5 µm or less.
8. The method according to any one of claims 1 to 7, wherein the inorganic particles containing the second metal are silver-supported phosphate glass having phosphate glass and silver supported on the phosphate glass. The composition for antivirus according to the above.
9. The antiviral composition according to any one of claims 1 to 8, wherein the solvent comprises an alcohol.
10. 抗 The antiviral composition according to claim 9, wherein the alcohol comprises ethanol.
11. The antiviral composition according to claim 10, wherein the content of the ethanol is less than 60% by mass based on the total mass of the solvent.
12. The antiviral composition according to any one of claims 1 to 11, wherein the pH is 9.0 to 11.5.
13. The antiviral composition according to any one of claims 1 to 12, which is a liquid preparation.
14. The antiviral composition according to any one of claims 1 to 12, which is a gel agent.
15. A composition for anti-norovirus, comprising the composition for anti-virus according to any one of claims 1 to 14.
16. A spray comprising: a spray container; and the antiviral composition according to any one of claims 1 to 14 contained in the spray container.
17. ワ イ A wiper comprising: a base fabric; and the antiviral composition according to any one of claims 1 to 14, impregnated in the base fabric.