JP7132332B2 - antiviral composition, anti-norovirus composition, spray, wiper, compound - Google Patents

Description

The present invention relates to antiviral compositions, anti-norovirus compositions, sprays, wipers, and compounds.

Unlike microorganisms such as bacteria and fungi, which have cellular structures, viruses do not have cellular structures, but are structures that have their genomes in outer shell proteins called capsids. Viruses are roughly divided into two types depending on whether the genome is DNA (deoxyribonucleic acid) or RNA (ribonucleic acid). It is further classified according to whether it is a membrane virus. Specifically, DNA type membranous viruses include human herpes virus and hepatitis B virus, DNA type non-membrane viruses include adenovirus and B19 virus, and RNA type membranous viruses include , influenza virus, and severe acute respiratory syndrome (SARS) coronavirus, RNA-type non-membranous viruses include norovirus, poliovirus, enterovirus, and the like.

In recent years, there has been a demand for drugs that can inactivate viruses (particularly noroviruses) by simpler means. For example, Patent Document 1 discloses an antiviral composition containing an antiviral component as an antiviral composition capable of inactivating viruses.

JP 2014-12715 A

The present inventors prepared an antiviral agent composition containing an antiviral component with reference to Patent Document 1, feline calicivirus (a closely related species of norovirus, similar to norovirus in genome composition, capsid structure and life). It is currently the most widely used surrogate virus due to its chemical properties), and revealed that there is room for further improvement of the antiviral activity.
In addition, the present inventors have also clarified that it is necessary to devise ways to further improve the solubility of the antiviral component in the composition containing the antiviral component. If the solubility of the antiviral component is poor, the composition itself becomes cloudy and the appearance properties are impaired. Furthermore, when a substrate is treated with a composition in which the antiviral component has poor solubility, the antiviral activity on the substrate tends to vary.

Accordingly, an object of the present invention is to provide an antiviral composition in which the antiviral component has excellent solubility and also has excellent antiviral activity.
Another object of the present invention is to provide an anti-norovirus composition comprising the antiviral composition.
Another object of the present invention is to provide a spray and a wiper using the antiviral composition.
Another object of the present invention is to provide a novel compound.

As a result of intensive studies aimed at solving the above problems, the present inventors have found that the above problems can be solved with an antiviral composition having a predetermined composition, and completed the present invention.
That is, the inventors have found that the above problems can be solved by the following configuration.

[1] One selected from the group consisting of a phenolic hydroxyl group, a carboxy group, a sulfo group, a sulfinic acid group, a phosphoric acid group, a phosphinic acid group, a phosphonic acid group, and a group represented by the following general formula (a) a compound containing the above acidic group and an aliphatic hydrocarbon group having 6 or more carbon atoms;
a solvent comprising an alcohol;
An antiviral composition having a pH of 9.0 to 14.0.
General formula (a): *—SO ₂ NHSO ₂ R ^x1
In general formula (a) above, R ^x1 represents a monovalent aliphatic hydrocarbon group, an aryl group, or a heteroaryl group. * represents a binding position.
[2] The antiviral composition of [1], wherein the compound is a compound represented by formula (1) described below.
[3] The compound represented by the above formula (1) is a compound represented by any one of the formulas (1-1) to (1-3) described below. A composition for viruses.
[4] The compound represented by the formula (1-1) is a compound represented by the formula (1-4) described later, and the compound represented by the formula (1-2) is the compound represented by the formula (1) described later. -5), and the compound represented by the formula (1-3) is a compound represented by the formula (1-6) described later, the antiviral composition according to [3]. thing.
[5] The antiviral composition according to any one of [1] to [4], wherein the aliphatic hydrocarbon group having 6 or more carbon atoms has 12 or more carbon atoms.
[6] The antiviral composition according to any one of [1] to [5], wherein the phenolic hydroxyl group has a pKa of 11.0 or more.
[7] The antiviral composition according to any one of [1] to [6], wherein the alcohol content is 25 to 100% by volume with respect to the total volume of the solvent.
[8] The antiviral composition according to any one of [1] to [7], wherein the alcohol includes an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms.
[9] The antiviral composition according to [8], wherein the alcohol having 2 or less carbon atoms contains ethanol, and the alcohol having 3 or more carbon atoms contains isopropanol.
[10] The antiviral composition of any one of [1] to [9], further comprising a surfactant.
[11] The antiviral composition of any one of [1] to [10], further comprising a quaternary ammonium salt.
[12] The antiviral composition according to any one of [1] to [11], wherein the content of the compound is 0.10% by mass or more relative to the total mass of the composition.
[13] The antiviral composition of any one of [1] to [12], which has a pH of 10.0 to 12.0.
[14] The antiviral composition according to any one of [1] to [13], which is a liquid formulation.
[15] The antiviral composition according to any one of [1] to [13], which is a gel.
[16] An anti-norovirus composition comprising the antiviral composition according to any one of [1] to [15].
[17] A spray comprising a spray container and the antiviral composition according to any one of [1] to [15] contained in the spray container.
[18] A wiper comprising a base fabric and the antiviral composition according to any one of [1] to [15] impregnated in the base fabric.
[19] A compound represented by any one of formulas (1-7) to (1-9) described below.

ADVANTAGE OF THE INVENTION According to this invention, the antiviral composition which is excellent in the solubility of an antiviral component, and is also excellent in antiviral activity can be provided.
Moreover, according to the present invention, an anti-norovirus composition comprising the antiviral composition can be provided.
Further, according to the present invention, a spray and a wiper using the antiviral composition can be provided.
Further, according to the present invention, novel compounds can be provided.

The present invention will be described in detail below.
The description of the constituent elements described below may be made based on representative embodiments of the present invention, but the present invention is not limited to such embodiments.
In this specification, a numerical range represented by "-" means a range including the numerical values before and after "-" as lower and upper limits.
In this specification, when there are multiple substituents, linking groups, etc. (hereinafter referred to as substituents, etc.) indicated by specific symbols, or when multiple substituents, etc. are defined at the same time, each substituent, etc. is It means that they may be the same or different from each other. This also applies to the number of substituents and the like.
Furthermore, in the description of a group (atomic group) in the present specification, a description that does not describe substitution or unsubstituted includes not only those having no substituents but also those having substituents. For example, an "alkyl group" includes not only an alkyl group having no substituent (unsubstituted alkyl group) but also an alkyl group having a substituent (substituted alkyl group).

[Antiviral composition]
The antiviral composition of the present invention (hereinafter also referred to as "the composition of the present invention")
One or more selected from the group consisting of a phenolic hydroxyl group, a carboxy group, a sulfo group, a sulfinic acid group, a phosphoric acid group, a phosphinic acid group, a phosphonic acid group, and a group represented by the general formula (a) described later. a compound (hereinafter also referred to as a "specific compound") containing an acidic group (hereinafter referred to as a "specific acidic group") and an aliphatic hydrocarbon group having 6 or more carbon atoms;
a solvent comprising an alcohol;
The pH is 9.0-14.0.
The composition of the present invention has remarkably excellent antiviral activity (in particular, antiviral activity against feline calicivirus (a closely related species of norovirus)) due to the above constitution. In addition, the specific compound has excellent solubility in solvents (particularly alcohol). In other words, the composition of the present invention has excellent solubility of the antiviral component.
It has also been confirmed that the composition of the present invention is also excellent in antibacterial activity against microorganisms such as bacteria and fungi (eg, Escherichia coli, Staphylococcus, etc.).

The antiviral composition of the present invention can be used in applications that are used to act on viruses to reduce their activity. In particular, it is preferably used as an anti-norovirus composition. The antiviral composition of the present invention can also be used for reducing the activity of microorganisms such as bacteria and fungi by acting on them.

Although the mechanism of action of the present invention is not clear in detail, the present inventors presume as follows.
In the composition of the present invention, the specific compound functions as an active ingredient (antiviral ingredient).
When the pH of the composition is in the range of 9.0 to 14.0, the phenolic hydroxyl group in the specific compound becomes a phenoxide anion by dissociating the hydrogen ion. It is speculated that this phenoxide anion deprotonates the acid groups present on the virus surface, thereby inactivating the virus.
Now, the present inventors have found that when the specific compound has a hydrophobic group (in other words, when the specific compound has an aliphatic hydrocarbon group with 6 or more carbon atoms), the antiviral activity of the composition is remarkably excellent. I found out. Viruses generally have a hydrophilic portion and a hydrophobic portion. Therefore, when the specific compound has a hydrophilic phenoxide anion site and an aliphatic hydrocarbon group having 6 or more carbon atoms, the adsorption rate of the specific compound to the virus increases, and as a result, the deprotonation It is presumed that the reaction proceeds more easily. On the other hand, as the compound becomes more hydrophobic, the solubility in aqueous solvents (especially alcohol) generally decreases, but the specific compound has a specific acidic group, so it is a hydrophobic aliphatic hydrocarbon having 6 or more carbon atoms. Despite having a group, it has excellent solubility in aqueous solvents (particularly alcohol). That is, the specific compound has both excellent antiviral activity and excellent solubility.
In addition, the present inventors believe that the alcohol contained in the solvent is also one of the factors that make the antiviral activity of the composition remarkably excellent.

In addition, as will be described later, when the pKa derived from acid dissociation of the phenolic hydroxyl group is 11.0 or more, the specific compound is more likely to deprotonate the acid group present on the virus surface, and is more excellent. shows antiviral activity. In addition, from the viewpoint that hydrogen ions are more easily dissociated from the phenolic hydroxyl group in the specific compound (in other words, phenoxide anions are easily generated), the upper limit of pKa derived from acid dissociation of the phenolic hydroxyl group is 14.0 or less. preferable.

As will be described later, when the composition of the present invention has a pH of 12.0 or less, corrosion of metals is less likely to occur, and the composition of the present invention can be used to disinfect a wider range of objects. For example, metals such as aluminum, copper, and brass are also resistant to corrosion.
Since the composition of the present invention is particularly excellent in antiviral activity against feline calicivirus (a closely related species of norovirus), it is preferably used as an anti-norovirus composition.

Each component contained in the composition of the present invention will be described in detail below.
[Specific compound]
The composition of the present invention is a group consisting of a phenolic hydroxyl group, a carboxy group, a sulfo group, a sulfinic acid group, a phosphoric acid group, a phosphinic acid group, a phosphonic acid group, and a group represented by the general formula (a) described later. It includes a compound (specific compound) containing one or more acidic groups (specific acidic groups) selected from the above and an aliphatic hydrocarbon group having 6 or more carbon atoms.
In addition, in this specification, the "phenolic hydroxyl group" intends the hydroxyl group which the carbon atom which comprises an aromatic ring has. The aromatic ring may be either an aromatic hydrocarbon ring or an aromatic heterocyclic ring, but is preferably an aromatic hydrocarbon ring.
Although the number of carbon atoms in the aromatic hydrocarbon ring is not particularly limited, it is preferably 6-18, more preferably 6-10. A benzene ring or a naphthalene ring is preferable as the aromatic hydrocarbon ring.
The aromatic heterocycle may be either a monocyclic structure or a polycyclic structure. When the aromatic heterocycle has a polycyclic structure, at least one of the rings included in the polycyclic structure is preferably a 5-membered ring or more.
The heteroatom contained in the aromatic heterocyclic group includes, for example, a nitrogen atom, an oxygen atom and a sulfur atom. The number of carbon atoms in the aromatic heterocyclic ring is not particularly limited, but preferably 5-18. Specific examples of the aromatic heterocyclic ring include pyridine ring, pyridazine ring, pyrimidine ring, pyrazine ring, triazine ring, thiophene ring, thiazole ring, and imidazole ring.

In addition, the specific compound is a polyvalent acid with multistage dissociation, and has a pKa derived from acid dissociation of the phenolic hydroxyl group and a pKa derived from acid dissociation of the specific acidic group. In the specific compound, the pKa derived from acid dissociation of the specific acidic group is smaller than the pKa derived from acid dissociation of the phenolic hydroxyl group.
The pKa derived from the acid dissociation of the phenolic hydroxyl group is preferably 11.0 or more, more preferably 12.0 or more, from the viewpoint of improving the efficiency of the deprotonation reaction of the virus and further improving the antiviral activity. On the other hand, the upper limit of the pKa derived from acid dissociation of the phenolic hydroxyl group is preferably 14.0 or less from the viewpoint of facilitating generation of phenoxide anions.

The above specific acidic groups include carboxy group (*--COOH), sulfo group (*--SO ₃ H), sulfinic acid group (*--SO ₂ H), phosphoric acid group (*--OP(=O)(OH) ₂ ), a phosphinic acid group (*--PH(=O)OH), a phosphonic acid group (*--P(=O)(OH) ₂ ), or a group represented by the following general formula (a). In addition, * represents a binding position.

General formula (a): *—SO ₂ NHSO ₂ R ^x1
In general formula (a) above, R ^x1 represents a monovalent aliphatic hydrocarbon group, an aryl group, or a heteroaryl group. * represents a binding position.

The monovalent aliphatic hydrocarbon group represented by R ^X1 is not particularly limited, and examples thereof include alkyl groups having 1 to 30 carbon atoms.
The aryl group represented by R ^X1 is not particularly limited, and examples thereof include aryl groups having 6 to 18 carbon atoms.
The heteroaryl group represented by R ^X1 is not particularly limited, and may be either a monocyclic structure or a polycyclic structure. The heteroatom contained in the heteroaryl group includes, for example, a nitrogen atom, an oxygen atom and a sulfur atom. The number of carbon atoms in the heteroaryl group is not particularly limited, but preferably 5 to 18.

The specific acidic group is preferably a carboxy group, a sulfo group, or a phosphate group, more preferably a carboxy group, from the viewpoint of superior antiviral activity.

The aliphatic hydrocarbon group having 6 or more carbon atoms contained in the specific compound may be linear, branched, or cyclic.
Moreover, the aliphatic hydrocarbon group may be either a saturated aliphatic hydrocarbon group or an unsaturated aliphatic hydrocarbon group. When the above aliphatic hydrocarbon group represents an unsaturated aliphatic hydrocarbon group, it may have both a double bond and a triple bond. When the aliphatic hydrocarbon group represents an alkenyl group, the number of double bonds in the alkenyl group may be one or two or more. When the aliphatic hydrocarbon group represents an alkynyl group, the number of triple bonds in the alkynyl group may be one or two or more.
Among others, the aliphatic hydrocarbon group preferably has 12 or more carbon atoms from the viewpoint of better antiviral activity.
Specific examples of aliphatic hydrocarbon groups having 6 or more carbon atoms include alkyl groups having 6 to 30 carbon atoms, alkenyl groups having 6 to 30 carbon atoms, and alkynyl groups having 6 to 30 carbon atoms.

The linear or branched alkyl group having 6 to 30 carbon atoms preferably has 6 to 18 carbon atoms, more preferably 12 to 18 carbon atoms. Specific examples of the linear and branched alkyl groups having 6 to 30 carbon atoms include n-hexyl group, 2-ethylhexyl group, isohexyl group, heptyl group, octyl group, and 3,7-dimethyloctyl. group, nonyl group, decyl group, undecyl group, dodecyl group, tridecyl group, tetradecyl group, pentadecyl group, hexadecyl group, heptadecyl group, octadecyl group, nonadecyl group, icosyl group, eicosyl, heneicosyl group, heneicosinyl group, docosyl group, tricosyl group, tetracosyl group, pentacosyl group, hexacosyl group, heptacosyl group, octacosyl group, nonacosyl group, and triacontyl group.

The linear or branched alkenyl group having 6 to 30 carbon atoms preferably has 6 to 18 carbon atoms, more preferably 12 to 18 carbon atoms. Specific examples of the linear and branched alkenyl groups having 6 to 30 carbon atoms include hexenyl, heptenyl, octenyl, nonenyl, decenyl, undecenyl, dodecenyl, tridecenyl, and tetradecenyl. group, pentadecenyl group, hexadecenyl group, octadecenyl group, nonadecenyl group, icosenyl group, eicosenyl group, henicosenyl group, heneicosenyl group, docosenyl group, tricosenyl group, detracosenyl group, pentacosenyl group, hexacosenyl group, hexacosenyl group, heptacosenyl group, octacosenyl group, nonacosenyl group, triacontenyl group, octadecadienyl group, octadecadienyl group, butadienyl group, pentadienyl group, hexadienyl group, octadienyl group and the like.
In the linear or branched alkenyl group having 6 to 30 carbon atoms, the position of the unsaturated bond is not limited and may be either cis or trans isomer. For example, an octadecenyl group is an oleyl group (cis-9-octadecenyl group) and an elaidyl group (trans-9-octadecenyl group); enyl group) and elaidolinoleyl group (trans, trans-9,12-octadecadienyl group), octadecatrienyl group is linolenyl group (cis, cis, cis-9,12,15-octadecadieneyl group). trienyl group) and elalidelenolenyl group (trans, trans, trans-9,12,15-octadecatrienyl group), and hexadecene group includes palmitoleyl group (cis-9-hexadecene group).

The linear or branched alkynyl group having 6 to 30 carbon atoms preferably has 6 to 18 carbon atoms, more preferably 12 to 18 carbon atoms. Specific examples of the linear and branched alkynyl groups having 6 to 30 carbon atoms include hexynyl group, heptynyl group, octynyl group, nonynyl group, decynyl group, undecynyl group, dodecynyl group, tridecynyl group, tetradecynyl group, pentadecynyl group, hexadecynyl group, heptadecynyl group, octadecynyl group, nonadecynyl group, icosinyl group, ecosinyl group, henicosinyl group, heneicosinyl group, docosinyl group, tricosinyl group, tetracosinyl group, pentakosinyl group, hexacosinyl group, heptakosinyl group, octacosinyl group, octacosinyl group , a nonacosinyl group, a triacontynyl group, and the like.

The alicyclic hydrocarbon group having 6 to 30 carbon atoms may be monocyclic, polycyclic or bridged cyclic. Specific examples of the ring constituting the alicyclic hydrocarbon group having 6 to 30 carbon atoms include cyclohexane, 2-isopropyl-5-methylcyclohexane, cyclohexene, cyclohexadiene, cycloheptane, cycloheptene, cycloheptadiene, and cyclooctane. , cyclooctene, cyclooctadiene, cyclooctatriene, cyclononane, cyclononene, cyclodecane, cyclodecene, cyclodecadiene, cyclodecatriene, cycloundecane, cyclododecane, bicycloheptane, bicyclohexane, bicyclohexene, tricyclohexene, norcalane, norpinane, Norbornane, norbornene, norbornadiene, tricycloheptane, tricycloheptene, decalin, adamantane and the like.

Among the aliphatic hydrocarbon groups having 6 or more carbon atoms, linear or branched alkyl groups having 6 or more carbon atoms (for example, linear A linear or branched alkyl group), or a linear alkenyl group having 6 or more carbon atoms (eg, a linear alkenyl group having 6 to 30 carbon atoms) is preferable, and a linear alkenyl group having 6 or more carbon atoms An alkyl group (e.g., a straight-chain alkyl group having 6 to 30 carbon atoms) or a straight-chain alkenyl group having 6 or more carbon atoms (e.g., a straight-chain alkenyl group having 6 to 30 carbon atoms) is more Preferably, a linear alkyl group having 6 to 18 carbon atoms or a linear alkenyl group having 6 to 18 carbon atoms is more preferable, and a linear alkyl group having 12 to 18 carbon atoms or a linear alkyl group having 12 to 18 carbon atoms A straight-chain alkenyl group is particularly preferred.

As the specific compound, a compound represented by the following formula (1) is preferable.

In formula (1), X ¹¹ to X ¹⁵ are each independently a group represented by -CR ¹¹ =, a group represented by =C(-L ^1A -A ¹ )-, =C(-L ^1B —R ¹ )— represents a group or a nitrogen atom.
provided that at least one of X ¹¹ to X ¹⁵ represents a group represented by =C(-L ^1A -A ¹ )-, and at least one of X ¹¹ to X ¹⁵ represents =C(-L ^1B - R ¹ )- represents a group represented by -.

X ¹¹ to X ¹⁵ are, among others, a group represented by -CR ¹¹ =, a group represented by =C(-L ^1A -A ¹ )-, or =C(-L ^1B -R ¹ )- It is preferable to represent the group represented by.

In Formula (1), R ¹¹ represents a hydrogen atom or a monovalent substituent.
Although the monovalent substituent represented by R ¹¹ is not particularly limited, examples thereof include those exemplified in Substituent Group W below.
(Substituent group W)
For example, halogen atoms (fluorine atom, chlorine atom, bromine atom, iodine atom, etc.), alkyl groups (including cycloalkyl groups, bicycloalkyl groups, and tricycloalkyl groups), alkenyl groups (cycloalkenyl groups, and bicycloalkenyl groups including), alkynyl group, aryl group, heterocyclic group (heterocyclic group, including heteroaryl group), cyano group, nitro group, alkoxy group, aryloxy group, silyloxy group, heterocyclicoxy group , acyloxy group, carbamoyloxy group, alkoxycarbonyloxy group, aryloxycarbonyloxy group, amino group (including anilino group), ammonio group, acylamino group, aminocarbonylamino group, alkoxycarbonylamino group, aryloxycarbonylamino group, sulfamoylamino group, alkyl or arylsulfonylamino group, mercapto group, alkylthio group, arylthio group, heterocyclicthio group, acylthio group, sulfamoyl group, alkyl or arylsulfinyl group, alkyl or arylsulfonyl group, acyl group, aryloxy carbonyl group, alkoxycarbonyl group, carbamoyl group, aryl or heterocyclic azo group, imido group, phosphino group, phosphinyl group, phosphinyloxy group, phosphinylamino group, phosphono group, silyl group, hydrazino group, ureido group, Boronic acid groups (--B(OH) ₂ ), sulfonic acid groups, carboxy groups, phosphate groups and other known substituents can be mentioned.
In addition, each group listed in the substituent group W may be further substituted with a group exemplified in the substituent group W described above. For example, an alkyl group may be substituted with a halogen atom.

R ¹¹ includes, among others, a hydrogen atom, a halogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heterocyclic group, an alkoxy group, an aryloxy group, a silyloxy group, a heterocyclicoxy group, a carbamoyloxy group, and an alkoxy group. carbonyloxy group, aryloxycarbonyloxy group, amino group (including anilino group), aminocarbonylamino group, alkoxycarbonylamino group, aryloxycarbonylamino group, mercapto group, alkylthio group, arylthio group, heterocyclicthio group, carbamoyl group, aryl or heterocyclic azo group, or silyl group, hydrogen atom, halogen atom, alkyl group, alkenyl group, alkynyl group, aryl group, heterocyclic group, alkoxy group, aryloxy group, silyloxy group, heterocyclic oxy group, or an aryl or heterocyclic azo group, more preferably a hydrogen atom.

When two adjacent groups among X ¹¹ to X ¹⁵ each represent a group represented by -CR ¹¹ =, the R ¹¹ groups may combine with each other to form a ring. The ring may be either aromatic or non-aromatic.
The mode in which R ¹¹ are bonded to each other to form a ring is not particularly limited, but is selected from, for example, the carbon atom, nitrogen atom, oxygen atom, and sulfur atom in the substituents exemplified as the substituent group W above. An aspect in which atoms are bonded to each other to form a ring is exemplified. For example, when two adjacent R ¹¹ are both alkenyl groups (for example, vinyl groups), a benzene ring can be formed when the terminal carbon atoms in each alkenyl group are bonded to each other. Also, when two adjacent R ¹¹ are both alkyl groups, when the terminal carbon atoms in each alkyl group are bonded to each other, an aliphatic hydrocarbon ring can be formed.

In Formula (1), L ^1A represents a single bond or a divalent linking group.
The divalent linking group represented by L ^1A is not particularly limited. For example, a divalent aliphatic hydrocarbon group (which may be linear, branched or cyclic, having Examples thereof include an alkylene group.Alkenylene groups and alkynylene groups may also be used.), arylene groups, heteroarylene groups, —O—, —S—, and —SO ₂ —. , —NR ^X2 —, —CO—, and groups in which two or more of these are combined. Here, R ^X2 represents a hydrogen atom or a monovalent substituent.
Hydrogen atoms in the divalent aliphatic hydrocarbon group, the arylene group, and the heteroarylene group may be substituted with other substituents such as halogen atoms.
Although the monovalent substituent represented by R ^X2 is not particularly limited, it represents, for example, a monovalent aliphatic hydrocarbon group, an aryl group, or a heteroaryl group. The monovalent aliphatic hydrocarbon group, aryl group and heteroaryl group represented by R ^X2 are the same as the monovalent aliphatic hydrocarbon group, aryl group and heteroaryl group represented by R ^X1 . Yes, and the preferred embodiments are also the same.

The divalent linking group represented by L ^1A includes, among others, a divalent aliphatic hydrocarbon group, an arylene group, a heteroarylene group, -O-, -S-, or a combination of two or more thereof. groups are preferred, and divalent aliphatic hydrocarbon groups are more preferred.
The number of carbon atoms in the divalent aliphatic hydrocarbon group is preferably 1-10, more preferably 1-6, and still more preferably 1 or 2.

L ^1A is preferably a single bond or a divalent aliphatic hydrocarbon group, more preferably a single bond, a vinylene group, or an ethynylene group, and still more preferably a single bond, from the viewpoint of superior antiviral properties.

In formula (1), A ¹ represents a specific acidic group. The specific acidic group is as described above.

In Formula (1), L ^1B represents a single bond or a divalent linking group.
The divalent linking group represented by L ^1B is not particularly limited, but examples include -O-, -S-, -SO-, -SO ₂ -, -NR ^X3 -, -CO-, -CS-, -N=N-, an arylene group, a heteroarylene group, and a combination of two or more of these. Here, R ^X3 represents a hydrogen atom or a monovalent substituent.
The hydrogen atoms in the arylene group and the heteroarylene group may be substituted with other substituents such as halogen atoms.
Although the monovalent substituent represented by R ^X3 is not particularly limited, it represents, for example, a monovalent aliphatic hydrocarbon group, an aryl group, or a heteroaryl group. The monovalent aliphatic hydrocarbon group, aryl group and heteroaryl group represented by R ^X3 have the same meanings as the monovalent aliphatic hydrocarbon group, aryl group and heteroaryl group represented by R ^X1 . Yes, and the preferred embodiments are also the same.

The divalent linking group represented by L ^1B includes, among others, -O-, -S-, -SO-, -SO ₂ -, -NR x3 -, -CO-, ^-CS- and -COO- , -COS-, -CSO-, -CONR ^X3 -, -SO ₂ NR ^X3 -, -NR ^X3 CONR ^X3 -, an arylene group, a heteroarylene group, or a combination of two or more of these is preferred.
In addition, the bonding direction of the divalent group (eg, -COO-) represented in this specification is not particularly limited. For example, when the above L ^1B in formula (1) is -COO-, L ^1B may be * ¹ -O-CO-*2 and *1-CO-O - *2 may be used.

L ^1B is a single bond, -O-, -S-, -NR ^X3 -, -CO-, -COO-, -CONR ^X3 -, -SO ₂ NR ^X3 -, -, or -NR ^X3 CONR ^X3 - is preferred, and a single bond, -O-, -S-, -NR ^X3 -, -CO-, -COO- or -CONR ^X3 - is more preferred, and a single bond, -O-, -COO- or -CONR ^X3 - is more preferred.

In formula (1), R ¹ represents an aliphatic hydrocarbon group having 6 or more carbon atoms. Specific examples of the aliphatic hydrocarbon group having 6 or more carbon atoms are as described above.

As the compound represented by the above formula (1), it is a compound represented by any one of the following formulas (1-1) to (1-3) in that it has more excellent antiviral activity. is preferred.

In formula (1-1), X ²¹ represents a group represented by -CR ²¹ = or a nitrogen atom. X ²¹ is preferably a group represented by -CR ²¹ =.
R ²¹ has the same definition as R ¹¹ in formula (1), and the preferred embodiments are also the same.
In formula (1-1), L ^2A , A ² , L ^2B , and R ² have the same meanings as L ^1A , A ¹ , L ^1B , and R ¹ in formula (1), and the preferred embodiments are also the same. is.

In formula (1-2), X ³¹ represents a group represented by -CR ³¹ = or a nitrogen atom. X ³¹ is preferably a group represented by -CR ³¹ =.
R ³¹ has the same definition as R ¹¹ in formula (1), and the preferred embodiments are also the same.
In formula (1-2), L ^3A , A ³ , L ^3B , and R ³ have the same meanings as L ^1A , A ¹ , L ^1B , and R ¹ in formula (1), and the preferred embodiments are also the same. is.

In formula (1-3), X ⁴¹ represents a group represented by -CR ⁴¹ = or a nitrogen atom. X ⁴¹ is preferably a group represented by -CR ⁴¹ =.
R ⁴¹ has the same definition as R ¹¹ in formula (1), and the preferred embodiments are also the same.
In formula (1-3), L ^4A , A ⁴ , L ^4B , and R ⁴ have the same meanings as L ^1A , A ¹ , L ^1B , and R ¹ in formula (1), and the preferred embodiments are also the same. is.

The compound represented by the above formula (1-1) is preferably a compound represented by the following formula (1-4) in terms of superior antiviral activity, and the compound represented by the above formula (1-2) The compound represented by the following formula (1-5) is preferable, and the compound represented by the above formula (1-3) is represented by the following formula (1-6). It is preferably a compound that

In formula (1-4), L ^2B and R ² have the same meanings as L ^1B and R ¹ in formula (1), respectively, and the preferred embodiments are also the same.
In formula (1-5), L ^3B and R ³ have the same meanings as L ^1B and R ¹ in formula (1), respectively, and the preferred embodiments are also the same.
In formula (1-6), L ^4B and R ⁴ have the same meanings as L ^1B and R ¹ in formula (1), respectively, and the preferred embodiments are also the same.

The compound represented by the above formula (1-4) is preferably a compound represented by the following formula (1-7), and the compound represented by the above formula (1-5) is preferably a compound represented by the following formula A compound represented by (1-8) is preferable, and a compound represented by the following formula (1-9) is preferable as the compound represented by the above formula (1-6).

In formula (1-7), L ^5B represents a single bond or a divalent linking group selected from the group consisting of —O—, —COO— and —CONR ^x4 —.
R ^X4 represents a hydrogen atom or a monovalent substituent. Although the monovalent substituent represented by R ^X4 is not particularly limited, it represents, for example, a monovalent aliphatic hydrocarbon group, an aryl group, or a heteroaryl group. The monovalent aliphatic hydrocarbon group, aryl group and heteroaryl group represented by R ^X4 have the same meanings as the monovalent aliphatic hydrocarbon group, aryl group and heteroaryl group represented by R ^X1 . Yes, and the preferred embodiments are also the same.

When L ^5B represents a single bond, R ⁵ represents an aliphatic hydrocarbon group having 16 or more carbon atoms, preferably an aliphatic hydrocarbon group having 16-30 carbon atoms.
When L ^5B represents —O—, R ⁵ represents an aliphatic hydrocarbon group having 9 or more carbon atoms, preferably an aliphatic hydrocarbon group having 9 to 30 carbon atoms, and an aliphatic hydrocarbon group having 10 to 30 carbon atoms. A hydrogen group is more preferred, and an aliphatic hydrocarbon group having 12 to 30 carbon atoms is even more preferred.
When L ^5B represents —COO—, R ⁵ represents an unsaturated aliphatic hydrocarbon group having 6 or more carbon atoms, preferably an unsaturated aliphatic hydrocarbon group having 6 to 30 carbon atoms, and 10 to 30 carbon atoms. is more preferable, and an unsaturated aliphatic hydrocarbon group having 12 to 30 carbon atoms is even more preferable.
When L ^5B represents —CONR ^x4 —, R ⁵ represents an aliphatic hydrocarbon group having 6 or more carbon atoms, preferably an aliphatic hydrocarbon group having 6 to 30 carbon atoms, and a carbonized aliphatic hydrocarbon group having 10 to 30 carbon atoms. A hydrogen group is more preferred, and an aliphatic hydrocarbon group having 12 to 30 carbon atoms is even more preferred.

In formula (1-8), L ^6B represents a single bond or a divalent linking group selected from the group consisting of —O—, —COO— and —CONR ^x4 —.
R ^X4 has the same definition as R ^X4 in formula (1-7), and the preferred embodiments are also the same.
When L ^6B represents a single bond, —O—, or —COO—, R ⁶ represents an unsaturated aliphatic hydrocarbon group having 6 or more carbon atoms, and an unsaturated aliphatic hydrocarbon group having 6 to 30 carbon atoms is preferred, an unsaturated aliphatic hydrocarbon group having 10 to 30 carbon atoms is more preferred, and an unsaturated aliphatic hydrocarbon group having 12 to 30 carbon atoms is even more preferred.
When L ^6B represents —CONR ^x4 —, R ⁶ represents an aliphatic hydrocarbon group having 6 or more carbon atoms, preferably an aliphatic hydrocarbon group having 6 to 30 carbon atoms, and an aliphatic hydrocarbon group having 10 to 30 carbon atoms. A hydrocarbon group is more preferred, and an aliphatic hydrocarbon group having 12 to 30 carbon atoms is even more preferred.

In formula (1-9), L ^7B represents a single bond or a divalent linking group selected from the group consisting of —O—, —COO— and —CONR ^x4 —.
R ^X4 has the same definition as R ^X4 in formula (1-7), and the preferred embodiments are also the same.
When L ^7B represents a single bond, R ⁷ represents an aliphatic hydrocarbon group having 9 or more carbon atoms, preferably an aliphatic hydrocarbon group having 9 to 30 carbon atoms, and an aliphatic hydrocarbon group having 10 to 30 carbon atoms. groups are more preferred, and aliphatic hydrocarbon groups having 12 to 30 carbon atoms are even more preferred.
When L ^7B represents —O—, R ⁷ represents an aliphatic hydrocarbon group having 11 or more carbon atoms, preferably an aliphatic hydrocarbon group having 11 to 30 carbon atoms, and a carbonized aliphatic hydrocarbon group having 12 to 30 carbon atoms. A hydrogen group is more preferred.
When L ^7B represents -COO-, R ⁷ represents an aliphatic hydrocarbon group having 6 or more carbon atoms, preferably an aliphatic hydrocarbon group having 6 to 30 carbon atoms, and a carbonized aliphatic hydrocarbon group having 10 to 30 carbon atoms. A hydrogen group is more preferred, and an aliphatic hydrocarbon group having 12 to 30 carbon atoms is even more preferred.
When L ^7B represents -CONR ^x4 -, R ⁷ represents a linear or branched aliphatic hydrocarbon group having 6 or more carbon atoms, and a linear or branched chain having 6 to 30 carbon atoms. An aliphatic hydrocarbon group is preferred, a straight or branched chain aliphatic hydrocarbon group having 10 to 30 carbon atoms is more preferred, and a straight or branched chain aliphatic hydrocarbon group having 12 to 30 carbon atoms is more preferred.

Specific compounds are exemplified below, but the present invention is not limited thereto. In the following examples, "R" represents any one of the monovalent substituents shown below.
(Monovalent substituent)
hexyl group, cyclopentylmethyl group, cyclohexyl group, heptyl group, cyclohexylmethyl group, octyl group, 2-ethylhexyl group, nonyl group, decyl group, 3,7-dimethyloctyl group, undecyl group, dodecyl group, 2-butyloctyl group , tridecyl group, tetradecyl group, 2-hexyloctyl group, pentadecyl group, hexadecyl group, 2-hexyldecyl group, heptadecyl group, octadecyl group, nonadecyl group, icosyl group, henicosyl group, docosyl group, tricosyl group, tetracosyl group, pentacosyl group, hexacosyl group, heptacosyl group, octacosyl group, nonacosyl group, triacontyl group, trans-2-hexenyl group, cis-2-hexenyl group, cis-3-hexenyl group, trans-2-heptenyl group, 2,4- hexadienyl group, 2,7-octadienyl group, cis-2-nonenyl group, cis-3-nonenyl group, trans-2-nonenyl group, trans, cis-2,6-nonadienyl group, 3,6-nonadienyl group, trans -2-octenyl group, cis-3-octenyl group, 2,4-decadienyl group, geranyl group, 2,4-undecadienyl group, trans-2-dodecenyl group, trans-2-dridecenyl group, 3,7,11- trimethyl-2,6,10-dodecatriene, oleyl group, propargyl group, 2-butynyl group, 3-butynyl group, 2-pentynyl group, 3-pentynyl group, 2-hexynyl group, 3-hexynyl group, 2-heptynyl 3-heptynyl, 2-octynyl, 3-octynyl, 2-decynyl, 3-decynyl, 2-nonynyl, and 3-nonynyl groups.

Among the monovalent substituents mentioned above, octyl group, 2-ethylhexyl group, nonyl group, decyl group, 3,7-dimethyloctyl group, undecyl group, dodecyl group, 2-butyloctyl group, tridecyl group, tetradecyl group, 2-hexyloctyl group, pentadecyl group, hexadecyl group, 2-hexyldecyl group, heptadecyl group, octadecyl group, nonadecyl group, icosyl group, heneicosyl group, docosyl group, tricosyl group, tetracosyl group, pentacosyl group, hexacosyl group , heptacosyl group, octacosyl group, nonacosyl group, triacontyl group, 2,7-octadienyl group, cis-2-nonenyl group, cis-3-nonenyl group, trans-2-nonenyl group, trans,cis-2,6-nonadienyl group, 3,6-nonadienyl group, trans-2-octenyl group, cis-3-octenyl group, 2,4-decadienyl group, geranyl group, 2,4-undecadienyl group, trans-2-dodecenyl group, trans-2 -dridecenyl group, 3,7,11-trimethyl-2,6,10-dodecatriene, oleyl group, 2-octynyl group, 3-octynyl group, 2-decynyl group, 3-decynyl group, 2-nonynyl group, or 3-nonynyl group is preferred, dodecyl group, 2-butyloctyl group, tridecyl group, tetradecyl group, 2-hexyloctyl group, pentadecyl group, hexadecyl group, 2-hexyldecyl group, heptadecyl group, octadecyl group, nonadecyl group, icosyl group, henicosyl group, docosyl group, tricosyl group, tetracosyl group, pentacosyl group, hexacosyl group, heptacosyl group, octacosyl group, nonacosyl group, triacontyl group, trans-2-dodecenyl group, trans-2-dridecenyl group, 3,7 , 11-trimethyl-2,6,10-dodecatriene or oleyl group is more preferable, dodecyl group, 2-butyloctyl group, tridecyl group, tetradecyl group, 2-hexyloctyl group, pentadecyl group, hexadecyl group, 2- A hexyldecyl group, a heptadecyl group, an octadecyl group, or an oleyl group is more preferred.

The compound represented by the above formula (1) can be synthesized by a known method.

A specific compound may be used individually by 1 type, and may use 2 or more types together.
In the composition of the present invention, the content of the specific compound (the total when multiple types are present) is preferably 0.01% by mass or more, more preferably 0.05% by mass or more, based on the total mass of the composition. Preferably, 0.10% by mass or more is more preferable, and 0.30% by mass or more is particularly preferable. Moreover, the upper limit is preferably 10% by mass or less, more preferably 5% by mass or less.

〔solvent〕
<Alcohol>
The composition of the invention contains alcohol as a solvent.
Although the alcohol is not particularly limited, for example, linear, branched and cyclic alcohols (including ether alcohols) having 1 to 20 carbon atoms are preferred. Specifically, methanol, ethanol, n-propanol, isopropanol, polyethylene glycol, propylene glycol, propylene glycol acetic acid monoester, glycerin, n-butanol, 2-butanol, i-butanol, t-butanol, butane-1,3 -diol, diethylene glycol, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, dipropylene glycol, n-pentanol, 2-pentanol, 3-pentanol, t-amyl alcohol, isoamyl alcohol, 2-methylbutanol, 3-methyl -2-butanol, 3-methyl-2-butenol, 3-methyl-3-butanol, 1-penten-3-ol, n-hexanol, capryl alcohol, 2-ethyl-1-hexanol, decanol, linalool, geraniol, Lauryl alcohol, myristyl alcohol, benzyl alcohol, phenylethyl alcohol, cinnamyl alcohol, 3-methoxypropanol, methoxymethoxyethanol, ethylene glycol, ethylene glycol mono-n-butyl ether, diethylene glycol mono-n-butyl ether, triethylene glycol mono-n -butyl ether, tetraethylene glycol mono-n-butyl ether, dipropylene glycol monobutyl ether, citronellol, terpineol, hydroxycitronellal, hydroxycitronellal dimethylacetal, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, propylene glycol monomethyl ether, Propylene glycol monoethyl ether, diacetone alcohol, ethylene glycol monoisopropyl ether, diethylene glycol monomethyl ether and the like.

From the viewpoint of safety, the alcohol is preferably a food additive. Among them, methanol, ethanol, propanol, isopropanol, polyethylene glycol, propylene glycol, propylene glycol acetic acid monoester, n-butanol, 2-butanol, butane. -1,3-diol, diethylene glycol, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, dipropylene glycol, 2-methyl-1-butanol, 1-decanol, 1-penten-3-ol, 2-ethyl-1-hexanol, 2-pentanol, 3-pentanol, 3-methyl-2-butanol, 3-methyl-2-butenol, 3-methyl-3-butanol, isoamyl alcohol, i-butanol, benzyl alcohol, citronellol, terpineol, hydroxycitro Neral or hydroxycitronellal dimethylacetal are preferred.

The composition of the present invention preferably contains an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms as the alcohol, in order to further reduce the variation in the antiviral activity value. Alcohols with 3 or more carbon atoms are more lipophilic than alcohols with 2 or less carbon atoms, and are considered easier to physically remove viruses and stains in which viruses are latent. For this reason, when a wiper is impregnated with a composition containing an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms and used for wiping, it is considered that the variation in the antiviral activity value becomes smaller. In addition, alcohols with 3 or more carbon atoms are assumed to have a higher surface activity function than alcohols with 2 or less carbon atoms, so the synergistic effect with the phenoxide anion is further strengthened, and the antiviral activity is improved. is also conceivable.
When an alcohol with 2 or less carbon atoms and an alcohol with 3 or more carbon atoms are used together, the volume ratio of alcohol with 3 or more carbon atoms to alcohol with 2 or less carbon atoms (volume of alcohol with 3 or more carbon atoms / volume of alcohol with 2 or less carbon atoms) volume of alcohol) is preferably 0.01 or more in terms of better antiviral activity and/or smaller variation in antiviral activity. Although the upper limit is not particularly limited, it is, for example, 5.00 or less, preferably 2.00 or less.
Alcohols with 2 or less carbon atoms preferably include ethanol, and alcohols with 3 or more carbon atoms preferably include isopropanol.

<Solvents other than alcohol>
The composition of the present invention may contain solvents other than alcohol.
Solvents other than alcohol include water and organic solvents (excluding alcohol).
The organic solvent is not particularly limited, but examples include acetone, methyl ethyl ketone, cyclohexane, ethyl acetate, isoamyl acetate, isopropyl acetate, geranyl acetate, cyclohexyl acetate, citronellyl acetate, cinnamyl acetate, terpinyl acetate, phenylethyl acetate, butyl acetate, and acetic acid. Benzyl, menthyl acetate, linalyl acetate, butyric acid, ethyl butyrate, butyl butyrate, isoamyl butyrate, cyclohexyl butyrate, ethylene dichloride, tetrahydrofuran, toluene, ethylene glycol dimethyl ether, acetylacetone, cyclohexanone, ethylene glycol monomethyl ether acetate, ethylene glycol ethyl ether acetate, ethylene Glycol monobutyl ether acetate, diethylene glycol dimethyl ether, diethylene glycol diethyl ether, propylene glycol monomethyl ether acetate, 2-methylpropanal, 2-methylbutyraldehyde, 3-methyl-2-butenal, 3-methylbutanal, L-perillaldehyde, acetaldehyde , ethyl acetoacetate, isoamyl acetate, isoamyl butyrate, isovaleraldehyde, isobutanal, isopropyl acetate, isopropyl myristate, isoamyl isovalerate, ethyl isovalerate, ethyl lactate, ethyl heptanoate, octanal, ethyl octanoate, octanal, Octanoic acid, ethyl octanoate, octylaldehyde, formic acid, isoamyl formate, geranyl formate, citronellyl formate, cinnamic aldehyde, ethyl cinnamate, methyl cinnamate, citral, citronellal, diisopropyl ether, diisopropyl disulfide, diisopropyl disulfide, diethyl Ether, diethyl tartrate, diethylpyrocarbonate, decanal, ethyl decanoate, triacetin, triethyl citrate, toluene, nonalactone, valeraldehyde, paramethylacetophenone, paramethoxybenzaldehyde, castor oil, isoamyl phenylacetate, isobutyl phenylacetate, phenylacetic acid Ethyl, butanal, propionaldehyde, propionic acid, isoamyl propionate, ethyl propionate, benzyl propionate, hexane, heptane, benzaldehyde, eucalyptol, ionone, terpinyl acetate, α-amylcinnamaldehyde, brominated vegetable oil, acetic acid, Dimethyl carbonate, ethyl lactate, thermal oxidation Soybean oil, esters of thermally oxidized soybean oil and glycerin, and liquid paraffin.

From the viewpoint of safety, the organic solvent is preferably a food additive such as acetone, methyl ethyl ketone, ethyl acetate, isoamyl acetate, isopropyl acetate, geranyl acetate, cyclohexyl acetate, citronellyl acetate, cinnamyl acetate, terpinyl acetate, phenyl acetate. Ethyl, butyl acetate, benzyl acetate, menthyl acetate, linalyl acetate, butyric acid, ethyl butyrate, butyl butyrate, isoamyl butyrate, cyclohexyl butyrate, 2-methylpropanal, 2-methylbutyraldehyde, 3-methyl-2-butenal-3-methyl Butanal, l-perillaldehyde, acetaldehyde, ethyl acetoacetate, isoamyl acetate, isoamyl butyrate, isovaleraldehyde, isobutanal, isopropyl acetate, isopropyl myristate, isoamyl isovalerate, ethyl isovalerate, ethyl lactate, ethyl heptanoate , octanal, octanoic acid, ethyl octanoate, octylaldehyde, formic acid, isoamyl formate, geranyl formate, citronellyl formate, cinnamic aldehyde, ethyl cinnamate, methyl cinnamate, citral, citronellal, diisopropyl ether, diisopropyl disulfide, diisopropyl Disulfide, diethyl ether, diethyl tartrate, diethylpyrocarbonate, decanal, ethyl decanoate, triacetin, triethyl citrate, toluene, nonalactone, valeraldehyde, paramethylacetophenone, paramethoxybenzaldehyde, castor oil, isoamyl phenylacetate, isobutyl phenylacetate , ethyl phenylacetate, butanal, propionaldehyde, propionic acid, isoamyl propionate, ethyl propionate, benzyl propionate, hexane, heptane, benzaldehyde, eucalyptol, ionone, terpinyl acetate, α-amylcinnamaldehyde, brominated vegetable oil, Acetic acid, dimethyl dicarbonate, ethyl lactate, thermally oxidized soybean oil, esters of thermally oxidized soybean oil and glycerin, or liquid paraffin are preferred.

In the composition of the present invention, the content of the solvent (the total when multiple types are present) is preferably 0.5 to 99.9% by mass, preferably 10 to 99.8% by mass, based on the total mass of the composition. %, more preferably 50 to 99.8% by mass, and particularly preferably 80 to 99.8% by mass.

In the composition of the present invention, the content of alcohol (the total when multiple types are present) is preferably 10 to 100% by volume relative to the total volume of the solvent, and 25 to 100% by volume is more preferable, and 30 to 100% by volume or more is even more preferable.

[pH of composition]
The composition of the present invention has a pH of 9.0-14.0. If the pH is less than 9.0, antiviral activity may be poor. The pH is preferably 10.0 or higher in terms of better antiviral activity. On the other hand, pH is 14.0 or less, and 12.0 or less is preferable in that corrosiveness to metal can be further suppressed.
The pH can be measured using a desktop pH meter "F-72S" (manufactured by Horiba, Ltd.) using a pH electrode "6337-10D" (manufactured by Horiba, Ltd.). A specific measuring method will be described later.
In addition, in this specification, pH intends the value in 25 degreeC.

[Optional component]
The composition of the present invention may contain components other than the above as long as the effects of the present invention are exhibited. Optional ingredients are not particularly limited, but examples include surfactants, disinfectants, disinfectants, disinfectants, antioxidants, pH adjusters, ultraviolet absorbers, chelating agents, moisturizers, thickeners/gelling agents. , preservatives, fragrances, and dyes. The composition of the present invention preferably contains a surfactant, a bactericidal agent, a disinfectant, a disinfectant, or an antioxidant, among others, in terms of better antiviral activity. It more preferably contains a salt (eg, benzalkonium chloride, etc.) or an antioxidant, and more preferably contains a surfactant or a quaternary ammonium salt (eg, benzalkonium chloride, etc.).

<Surfactant and emulsifier>
The compositions of the invention preferably contain surfactants and/or emulsifiers. When a base fabric is impregnated with the composition of the present invention containing a surfactant and/or an emulsifier and used as a wiper, less residue is left unwiped and the cleaning property is more excellent.
Surfactants and emulsifiers are not particularly limited. is not included), and nonionic surfactants.

Examples of ionic surfactants include alkyl sulfates (sodium dodecyl sulfate, etc.), alkylbenzenesulfonates (sodium dodecylbenzenesulfonate, etc.), alkyl phosphates, and cholate salts (sodium deoxycholate, sodium lithocholate, etc.). , and sodium cholate); cationic surfactants such as alkyldiaminoethylglycine hydrochloride;

As nonionic surfactants, compounds having more than 20 carbon atoms are preferable, and examples include mono-, di-, or polyglycerin fatty acid esters, propylene glycol fatty acid monoesters, sorbitan fatty acid esters, sucrose fatty acid esters, and the like. Ester type; Ether type such as polyoxyethylene alkyl ether, polyalkylene alkyl ether, and polyoxyethylene polyoxypropylene glycol (manufactured by Kao Corporation, Emulgen series, etc.); Fatty acid polyethylene glycol, fatty acid polyoxyethylene sorbitan, etc. ester ether type; and alkanolamide type such as fatty acid alkanolamide.
Specific examples of nonionic surfactants include polyethylene glycol monolauryl ether, polyethylene glycol monostearyl ether, polyethylene glycol monocetyl ether, polyethylene glycol monolauryl ester, and polyethylene glycol monostearyl ester.

Although the emulsifier is not particularly limited, in the case of a nonionic emulsifier, it preferably has more than 20 carbon atoms. Specific examples of emulsifiers include oleate (salt forms include calcium salt, sodium salt and potassium salt), caprate (salt forms include calcium salt, sodium salt and potassium salts), caprylate (salt forms include calcium salt, sodium salt and potassium salt), laurate (salt forms include calcium salt, sodium salt and potassium salts), gum rosin glycerin ester, starch sodium octenylsuccinate, stearyl citrate, citric acid monoglyceride, lactic acid and fatty acid esters of glycerin, fatty acid esters of mono-, di-, or polyglycerin, stearic acid Salts (Salt forms include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt.), Myristate (Salt forms include calcium salt, magnesium salt, ammonium salt , aluminum salts, potassium salts, and sodium salts.), palmitates (salt forms include calcium salts, magnesium salts, ammonium salts, aluminum salts, potassium salts, and sodium salts.), Calcium stearoyl lactylate, sodium stearoyl lactylate, sorbitan fatty acid ester, dioctyl sodium sulfosuccinate, lecithin, hydroxylated lecithin, partially hydrolyzed lecithin, sunflower lecithin, enzyme-treated lecithin, propylene glycol fatty acid ester, polyoxyethylene sorbitan monolaurate, poly monostearate Oxyethylene sorbitan, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan oleate, quillaya extract, vegetable sterol, sphingolipid, soybean saponin, bile powder, animal sterol, fractionated lecithin, yuccaform extract, egg yolk lecithin , tall oil, and rosin glycerin esters.

Among the above-mentioned surfactants and emulsifiers, food additives are preferable from the viewpoint of safety, and cholate salts (the salt forms include calcium salts, sodium salts, and potassium salts). , deoxycholate (salt forms include calcium, sodium, and potassium salts), oleate (salt forms include calcium, sodium, and potassium salts. ), caprate (salt forms include calcium, sodium, and potassium salts), caprylate (salt forms include calcium, sodium, and potassium salts. ), laurate (salt forms include calcium, sodium, and potassium salts), gum rosin glycerin ester, starch sodium octenyl succinate, triethyl citrate, stearyl citrate, citric acid monoglyceride, Lactic acid and fatty acid esters of glycerin, fatty acid esters of mono-, di-, or polyglycerin, sucrose fatty acid esters, stearates (in the form of salts, calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt.), myristate (salt forms include calcium salt, magnesium salt, ammonium salt, aluminum salt, potassium salt, and sodium salt.), palmitate (salt forms include calcium, magnesium, ammonium, aluminum, potassium, and sodium salts.), calcium stearoyl lactylate, sodium stearoyl lactylate, sorbitan fatty acid esters, dioctyl sodium sulfosuccinate, lecithin, hydroxylated Lecithin, partially hydrolyzed lecithin, sunflower lecithin, enzyme-treated lecithin, propylene glycol fatty acid ester, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan oleate, quillaya extract plant sterols, sphingolipids, soybean saponins, bile powder, animal sterols, fractionated lecithin, yuccaform extract, egg yolk lecithin, tall oil, or rosin glycerin esters.

Surfactants and emulsifiers may be used singly or in combination of two or more.
When the composition of the present invention contains a surfactant and / or an emulsifier, the content of the surfactant and emulsifier (the total if there are multiple types) is 0.01 to 0.01 with respect to the total mass of the composition. 2% by mass is preferred, 0.05 to 2% by mass is more preferred, and 0.05 to 1% by mass is even more preferred.

<Bactericidal agent, disinfectant, and disinfectant>
Bactericides, disinfectants, and disinfectants are not particularly limited. , lactic acid 6,9-diamino-2-ethoxyacridine monohydrate) and the like. Among them, quaternary ammonium salts are preferable in that they have superior antiviral activity when combined with the composition of the present invention.

(Quaternary ammonium salt)
The quaternary ammonium salt is not particularly limited, and examples thereof include compounds represented by the following formulas (2) to (5).

In formula (2), R ²¹ to R ²⁴ each independently represent an aliphatic hydrocarbon group, an aryl group, an aralkyl group, or a heteroaryl group.
The aliphatic hydrocarbon group represented by R ²¹ to R ²⁴ may be linear, branched or cyclic.
Also, the aliphatic hydrocarbon groups represented by R ²¹ to R ²⁴ may contain heteroatoms. The type of heteroatom is not particularly limited, but examples include an oxygen atom, a nitrogen atom, a sulfur atom, a selenium atom, a tellurium atom, and the like. Among them, -Y ¹ -, -N(Ra)-, -C(=Y ² )-, -CON(Rb)-, -C(=Y ³ )Y ⁴ - are more excellent in antiviral activity. , --SOt--, --SO ₂ N(Rc)--, or combinations thereof.
Y ¹ -Y ⁴ are each independently selected from the group consisting of oxygen, sulfur, selenium and tellurium atoms. Among them, an oxygen atom or a sulfur atom is preferable from the viewpoint of easier handling. t represents an integer of 1-3. Each of Ra, Rb and Rc above independently represents a hydrogen atom or an alkyl group having 1 to 10 carbon atoms.
When the aliphatic hydrocarbon group contains a heteroatom, --CH ₂ -- is substituted with the heteroatom.

Specifically, the aliphatic hydrocarbon group represented by R ²¹ to R ²⁴ includes an alkyl group (preferably having 1 to 30 carbon atoms, more preferably 1 to 20 carbon atoms), an alkenyl group (having 2 to preferably 30, more preferably 2 to 20 carbon atoms), or an alkynyl group (preferably 2 to 30 carbon atoms, more preferably 2 to 20 carbon atoms). Among them, an alkyl group is preferred.

The aryl group represented by R ²¹ to R ²⁴ is not particularly limited, and is preferably an aryl group having 6 to 18 carbon atoms, and specific examples include phenyl and naphthyl groups.

Although the aralkyl group represented by R ²¹ to R ²⁴ is not particularly limited, for example, an aralkyl group having 7 to 15 carbon atoms is preferable. (1-naphthyl)ethyl group, triphenylmethyl group, pyrenylmethyl group and the like.

The heteroaryl group represented by R ²¹ to R ²⁴ is preferably, for example, a heteroaryl group having 3 to 12 carbon atoms, such as furyl, thiofuryl, pyridyl, pyrazole, imidazolyl, benzimidazolyl, indolyl, group, quinolyl group, isoquinolyl group, purine group, pyrimidyl group, pyrazyl group, oxazolyl group, thiazolyl group, triazyl group, carbazolyl group, quinoxalyl group, thiazine group and the like.

The aliphatic hydrocarbon groups, aryl groups, aralkyl groups and heteroaryl groups represented by R ²¹ to R ²⁴ may further have substituents. Examples of the substituent include those exemplified in the group W of substituents described above.

X ⁻ represents a monovalent anion other than hydroxide ion.
Specific examples of X ⁻ include halide ions (eg, F ⁻ , Cl ⁻ , Br ⁻ , I ⁻ , Br ₃ ⁻ , Br ₂ Cl ⁻ , I ₃ ⁻ , IBr ₂ ⁻ , Cl ₂ Br ⁻ , HF ₂ ⁻ , H ₂ F ₃ ⁻ , AuBr ₂ ⁻ , AuCl ₂ ⁻ , AuI ₂ ⁻ , and FeCl ₄ ⁻ ), carboxylate anions, cyanide anions, sulfonimide anions (N ⁻ (SO ₂ R ) ₂ : R is a fluorine atom, a hydrocarbon group (for example, an alkyl group having 1 to 20 carbon atoms), or a perfluorohydrocarbon group (for example, a perfluoroalkyl group having 1 to 20 carbon atoms) ), borohydride anion, dichloroiodate anion, tetrafluoroborate anion, hexafluorophosphate anion, perchlorate anion, sulfate anion, hydrogen sulfate anion, nitrate anion, dicyanamide anion [N ⁻ ( CN) ₂ ], azide anion (N ₃ ⁻ ), alkane or arylsulfonate anion, perfluoroalkane or arylsulfonate anion, alkyl or aryl sulfate anion (ROSO ₃ ⁻ : R is an an alkyl group or an aryl group having 6 to 18 carbon atoms.), an alkyl or aryl phosphate ester anion ((RO) ₂ PO ₂ ⁻ : each R is independently an alkyl group having 1 to 20 carbon atoms, or a carbon represents an aryl group of numbers 6 to 18), thiocyanide anion (S ^-- CN), triacetoxyborohydride anion, perruthenate anion ( _RuO4- ⁾ , Cu( _CF3 ) _4- ^, C(CN) ₃ ^- , and CF ₃ BF ₃ ^- .

Compounds represented by Formula (2) are exemplified below, but the present invention is not limited thereto.

In formula (3), X ^- has the same meaning as X ^- in formula (2), and the preferred embodiments are also the same.
R ³¹ and R ³² have the same meanings as R ²¹ to R ²⁴ in formula (2), and the preferred embodiments are also the same.
Y ³¹ and Y ³² each independently represent -C(R ³³ ) ₂ -, -NR ³⁴ -, -O-, -CO-, -CO ₂ -, -S-, -SO-, or -SO ₂ - represents. In addition, when there are multiple Y ³² in the formula (2), the multiple Y ³² may be the same or different.
R ³³ represents a hydrogen atom or a monovalent organic group selected from the group consisting of aliphatic hydrocarbon groups, aryl groups, aralkyl groups, heteroaryl groups and halogen atoms.
R ³⁴ represents a hydrogen atom or a monovalent organic group selected from the group consisting of aliphatic hydrocarbon groups, aryl groups, aralkyl groups and heteroaryl groups.
The aliphatic hydrocarbon group, aryl group, aralkyl group and heteroaryl group represented by R ³³ and R ³⁴ are the aliphatic hydrocarbon groups and aryl groups represented by R ²¹ to R ²⁴ in formula (2). , aralkyl group, or heteroaryl group, and the preferred embodiments are also the same.
Halogen atoms represented by R ³³ and R ³⁴ include fluorine, chlorine, bromine and iodine atoms.

The aliphatic hydrocarbon group, aryl group, aralkyl group or heteroaryl group represented by R ³³ and R ³⁴ may further have a substituent. Examples of the substituent include those exemplified in the group W of substituents described above.

When Y ³¹ or Y ³² represents —C(R ³³ ) ₂ — or —NR ³⁴ —, the monovalent organic group represented by R ³¹ is linked to R ³³ or R ³⁴ to Aromatic or non-aromatic rings may be formed.
Also, R ³¹ and R ³² may be linked together to form an aromatic or non-aromatic ring.
n represents an integer from 1 to 18;

Compounds represented by Formula (3) are exemplified below, but the present invention is not limited thereto.

In formula (4), X ^- has the same meaning as X ^- in formula (2), and the preferred embodiments are also the same.
R ⁴¹ has the same meaning as R ²¹ to R ²⁴ in formula (2), and the preferred embodiments are also the same.
Y ⁴¹ to Y ⁴⁵ each independently represent a nitrogen atom or =CR ⁴² -. R ⁴² represents a hydrogen atom or a monovalent substituent.
Although the monovalent substituent represented by R ⁴² is not particularly limited, examples thereof include those exemplified in the above-described substituent group W.
When two or more of Y ⁴¹ to Y ⁴⁵ represent ═CR ⁴² —, the R ^42s substituted on adjacent carbon atoms are linked to each other to form an aromatic or non-aromatic ring. may
When Y ⁴¹ to Y ⁴⁵ represent ═CR ⁴² —, the monovalent substituent represented by R ⁴² is linked to R ⁴¹ to form an aromatic or non-aromatic ring. good too.

Compounds represented by Formula (4) are exemplified below, but the present invention is not limited thereto.

In formula (5), X ^- has the same meaning as X ^- in formula (2), and the preferred embodiments are also the same.
Y ⁵¹ to Y ⁵³ have the same meanings as Y ⁴¹ to Y ⁴⁵ in formula (4), and the preferred embodiments are also the same.
Y ⁵⁴ represents >NR ⁵¹ , a sulfur atom, or an oxygen atom.
R ⁵¹ and R ⁵² have the same definitions as R ²¹ to R ²⁴ in formula (2), and the preferred embodiments are also the same.

Compounds represented by Formula (5) are exemplified below, but the present invention is not limited thereto.

(Antibacterial agent containing metal)
The metal-containing antibacterial agent is not particularly limited, and known agents can be used.
Examples of the metals include gold, silver, copper, mercury, zinc, iron, lead, bismuth, titanium, tin, and nickel. The form of the metal contained in the metal-containing antibacterial agent is not particularly limited, and examples include forms such as metal particles, metal ions, and metal salts (including metal complexes). Among them, the metal is preferably gold, silver, or copper in terms of superior antibacterial properties.

Moreover, the antibacterial agent containing a metal may be a carrier and a metal-carrying carrier containing the metal carried on the carrier.
The type of carrier is not particularly limited, and known carriers can be used. Examples of carriers include inorganic oxides (e.g., zeolite (crystalline aluminosilicate), silica gel, silicates such as clay minerals, glass (including water-soluble glass), zirconium phosphate, calcium phosphate, etc.), activated carbon. , metal carriers, and organic metals.

As the metal-containing antibacterial agent, a silver-containing antibacterial agent is preferable because of its superior antibacterial properties.
Specific examples of antibacterial agents containing silver include silver salts such as silver nitrate, silver chloride, silver sulfate, silver lactate, and silver acetate; silver complexes such as silver ammonia complexes, silver chloro complexes, and silver thiosulfato complexes; Particles; silver ions; silver-supported carriers in which these are supported on the above carriers; and the like.

(photocatalyst)
The photocatalyst is not particularly limited as long as it is a substance known to exhibit photocatalytic action, and examples thereof include TiO ₂ , SrTiO ₂ , ZnO, CdS, SnO ₂ and WO ₃ .

(Aldehyde compound)
Although the aldehyde compound is not particularly limited, examples include glutaral, phthalal, formalin, and the like.

(iodine compound)
Although the iodine-based compound is not particularly limited, examples thereof include povidone-iodine and iodine tincture.

(piguanide compound)
Examples of the piguanide compound include, but are not limited to, chlorhexidine gluconate, chlorhexidine hydrochloride, and chlorhexidine acetate.

Bactericides, disinfectants, and disinfectants may be used singly or in combination of two or more.
When the composition of the present invention contains a bactericidal agent, a disinfectant, and / or a disinfectant, the content of the bactericidal agent, disinfectant, and disinfectant (if there are multiple types, the total) 0.001 to 10% by mass is preferable, 0.01 to 3% by mass is more preferable, and 0.01 to 1% by mass is even more preferable with respect to the total mass.

<Antioxidant>
The compositions of the invention preferably contain an antioxidant. Antiviral activity is better when the composition of the present invention contains an antioxidant.
Antioxidants are not particularly limited. Various antioxidants as described can be used.

Antioxidants include ascorbic acid, ascorbic acid derivatives, and salts thereof; erythorbic acid, erythorbic acid derivatives, and salts thereof; compounds having a phenolic hydroxyl group (except for the specific compounds described above); phenylenediamine amine compounds such as;

Examples of the ascorbic acid, ascorbic acid derivatives, and salts thereof include L-ascorbic acid, sodium L-ascorbate, potassium L-ascorbate, calcium L-ascorbate, L-ascorbic acid phosphate, L- Magnesium salt of ascorbyl phosphate, L-ascorbyl sulfate, L-ascorbyl sulfate disodium salt, L-ascorbyl stearate, L-ascorbyl 2-glucoside, L-ascorbyl palmitate, and L-ascorbyl tetraisopalmitate.

Examples of the erythorbic acid, erythorbic acid derivatives, and salts thereof include erythorbic acid, sodium erythorbate, potassium erythorbate, calcium erythorbate, erythorbate phosphate, and erythorbate sulfate.

Examples of compounds having a phenolic hydroxyl group include polyphenols (e.g., catechin contained in tea extract), nordihydroguaiaretic acid (NDGA), gallates (e.g., propyl gallate, butyl gallate, and octyl gallate, etc.), BHT (dibutylhydroxytoluene), BHA (butylhydroxyanisole), carcinonic acids (rosemary extract, etc.), ferulic acid, vitamin E, bisphenols, and the like.
Examples of the vitamin E include tocopherol (vitamin E) and its derivatives, tocotrienol and its derivatives, and the like.
Examples of the tocopherols and derivatives thereof include dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol, dl-δ-tocopherol, dl-α-tocopherol acetate, dl-α-tocopherol nicotinate, dl-α-tocopherol linoleate, dl-α-tocopherol succinate, acetate esters thereof, and the like.
Examples of the above tocotrienols and derivatives thereof include α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, acetate esters thereof, and the like.

Examples of the amine compounds include phenylenediamine, diphenyl-p-phenylenediamine, 4-amino-p-diphenylamine, and the like.

From the viewpoint of safety, the above-mentioned antioxidants are preferably food additives, such as 4-hexylresorcin, BHT, butylhydroxyanisole, disodium calcium ethylenediaminetetraacetate, L-ascorbic acid, and L-ascorbic acid. calcium acid, L-ascorbyl stearate, sodium L-ascorbate, L-ascorbyl palmitate, tert-butyl hydroquinone, d-α-tocopherol concentrate, dl-α-tocopherol, anoxomer, isoascorbic acid, Erythorbic acid, sodium erythorbate, isopropyl citrate, guaiac butter, guaiac resin, dilauryl thiodipropionate, thiodipropionic acid, distearyl thiodipropionate, sodium thiosulfate, nordihydroguaiaretic acid, pyrosulfite Potassium, sodium pyrosulfite, ethyl protocatechuate, ferulic acid, propyl gallate, isoamyl gallate, dodecyl gallate, potassium sulfite, sodium sulfite, potassium bisulfite, sodium bisulfite, or stannous chloride are preferred.

An antioxidant may be used individually by 1 type, and may use 2 or more types together.
When the composition of the present invention contains an antioxidant, the content of the antioxidant (the total when multiple types are present) is preferably 0.001 to 2% by mass relative to the total mass of the composition, 0.01 to 1% by mass is more preferable, and 0.01 to 0.5% by mass is even more preferable.

<pH adjuster>
Although the pH adjuster is not particularly limited, metal alkoxides (e.g., sodium methoxide, sodium ethoxide, etc.), metal oxides (e.g., calcium oxide, magnesium oxide, etc.), hydrogen carbonates (ammonium hydrogen carbonate, carbonate sodium hydrogen carbonate, potassium hydrogen carbonate, calcium hydrogen carbonate, etc.), metal hydroxides (calcium hydroxide, magnesium hydroxide, potassium hydroxide, sodium hydroxide, lithium hydroxide, aluminum hydroxide, rubidium hydroxide, cesium hydroxide , strontium hydroxide, barium hydroxide, europylium hydroxide (II), and thallium hydroxide (I), etc.), carbonates (ammonium carbonate, potassium carbonate, calcium carbonate, sodium carbonate, magnesium carbonate, cesium carbonate, etc.), quaternary ammonium hydroxide, organic bases (guanidine derivatives, diazabicycloundecene, diazabicyclononene, etc.), phosphazene bases, proazaphosphatrane bases, and the like.
As the pH adjuster, those used as food additives are preferable from the viewpoint of safety, and sodium methoxide, calcium oxide, magnesium oxide, ammonium hydrogen carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, calcium hydrogen carbonate, hydroxide Calcium, magnesium hydroxide, potassium hydroxide, sodium hydroxide, ammonium carbonate, potassium carbonate, calcium carbonate, sodium carbonate or magnesium carbonate are preferred.

A pH adjuster may be used individually by 1 type, and may use 2 or more types together.
When the composition of the present invention contains a pH adjuster, the content of the pH adjuster (the total if there are multiple types) can be changed as appropriate depending on the content of the specific compound, etc., and cannot be limited. , preferably 0.001 to 30% by weight, more preferably 0.005 to 20% by weight, and 0.01 to 10 % by mass is more preferred.

<Ultraviolet absorber>
UV absorbers are not particularly limited, but for example, salicylic acid compounds such as homomenthyl salicylate, octyl salicylate, and triethanolamine salicylate; para-aminobenzoic acid, ethyldihydroxypropyl para-aminobenzoic acid, glyceryl para-aminobenzoic acid, octyldimethyl para-aminobenzoic acid , amyl paradimethylaminobenzoate, and para-aminobenzoic acid compounds such as 2-ethylhexyl paradimethylaminobenzoate; 4-(2-β-glucopyranosiloxy)propoxy-2-hydroxybenzophenone, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenonedisulfonate, 2-hydroxy-4-methoxybenzophenone, and hydroxymethoxybenzophenone sulfonic acid and its trihydrate, sodium hydroxymethoxybenzophenone sulfonate, 2-hydroxy-4-methoxybenzophenone-5-sulfuric acid, 2, 2'-dihydroxy-4-methoxybenzophenone, 2,4-dihydroxybenzophenone, 2,2'4,4'-tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, and 2-hydroxy- Benzophenone compounds such as 4-N-octoxybenzophenone; 2-ethylhexyl paramethoxycinnamate (also known as octyl paramethoxycinnamate), glyceryl mono-2-ethylhexanoate di-paramethoxycinnamate, 2,5 - methyl diisopropylcinnamate, 2,4,6-tris[4-(2-ethylhexyloxycarbonyl)anilino]-1,3,5-triazine, methylbis(trimethylsiloxy)silylisopentyl trimethoxycinnamate , paramethoxycinnamate isopropyl-diisopropylcinnamate ester mixture, and cinnamic acid compounds such as p-methoxyhydrocinnamic acid diethanolamine salt; 2-phenyl-benzimidazole-5-sulfuric acid, 4-isopropyldibenzoylmethane , and benzoylmethane compounds such as 4-tert-butyl-4'-methoxydibenzoylmethane; 2-cyano-3,3-diphenylprop-2-enoic acid-2-ethylhexyl ester (also known as octocrylene), dimethoxybenzylidene 2-ethylhexyl dioxoimidazolidinepropionate, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, cinoxate, methyl -O-aminobenzoate, 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate, 3-(4-methylbenzylidene)camphor, octyltriazone, 4-(3,4-dimethoxyphenylmethylene)-2,5 2-ethylhexyl-dioxo-1-imidazolidinepropionate, polymer derivatives thereof, and silane derivatives.

One type of ultraviolet absorber may be used alone, or two or more types may be used in combination.
When the composition of the present invention contains an ultraviolet absorber, the content of the ultraviolet absorber (the total when multiple types are present) is preferably 0.001 to 3% by mass relative to the total weight of the composition, 0.001 to 2% by mass is more preferable, and 0.001 to 1% by mass is even more preferable.

<Chelating agent>
The chelating agent is not particularly limited, but examples include aminopolycarboxylic acid chelating agents, aromatic or aliphatic carboxylic acid chelating agents, amino acid chelating agents, phosphonic acid chelating agents, phosphoric acid chelating agents, and hydroxycarboxylic acids. system chelating agents, polyelectrolyte (including oligomeric electrolytes) chelating agents, dimethylglyoxime, thioglycolic acid, phytic acid, glyoxylic acid, and glyoxalic acid. These chelating agents may be in free acid form or in the form of salts such as sodium salts, potassium salts and ammonium salts.

Examples of aminopolycarboxylic acid-based chelating agents include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N-(2-hydroxyethyl)iminodiacetic acid, diethylenetriaminepentaacetic acid, N-(2 -hydroxyethyl)ethylenediaminetriacetic acid, glycol ether diaminetetraacetic acid, glutamic acid diacetic acid, aspartic acid diacetic acid, salts thereof, and the like.

Examples of aromatic or aliphatic carboxylic acid-based chelating agents include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvic acid, salicylic acid, Acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranilic acid), phthalic acid, fumaric acid, trimellitic acid, gallic acid, hexahydrophthalic acid, salts thereof, and the like.

Examples of amino acid-based chelating agents include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine, and salts thereof.

Phosphonic acid-based chelating agents include, for example, iminodimethylphosphonic acid, alkyldiphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid, and salts thereof.

Phosphate-based chelating agents include, for example, orthophosphoric acid, pyrophosphoric acid, triphosphoric acid, and polyphosphoric acid.

Examples of hydroxycarboxylic acid-based chelating agents include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartaric acid, lactic acid, and salts thereof.

Polyelectrolyte (including oligomer electrolyte)-based chelating agents include, for example, acrylic acid polymers, maleic anhydride polymers, α-hydroxyacrylic acid polymers, itaconic acid polymers, and constituent monomers 2 of these polymers. Examples thereof include copolymers composed of more than one species, and epoxy succinic acid polymers.

A chelating agent may be used individually by 1 type, and may use 2 or more types together.
When the composition of the present invention contains a chelating agent, the content of the chelating agent (the total if there are more than one) is preferably 0.001 to 3% by mass, preferably 0.001 to 3% by mass, based on the total mass of the composition. 001 to 2% by mass, and even more preferably 0.001 to 1% by mass.

<Moisturizer>
Moisturizers are not particularly limited, and examples include deoxyribonucleic acid, mucopolysaccharides, hyaluronic acid, chondroitin sulfate, aloe extract, gelatin, elastin, chitin, chitosan, hydrolyzed eggshell membrane, polyoxyethylene methyl glucoside, polyoxypropylene methyl Glucoside, sodium lactate, urea, sodium pyrrolidonecarboxylate, betaine, and whey.

Moisturizers may be used singly or in combination of two or more.
When the composition of the present invention contains a humectant, the content of the humectant (the total when there are multiple kinds of humectants) is preferably 0.001 to 3% by mass, preferably 0.001 to 3% by mass, based on the total mass of the composition. 001 to 2% by mass, and even more preferably 0.001 to 1% by mass.

<Thickening agent and gelling agent>
Examples of thickeners and gelling agents include maleic anhydride/methyl vinyl ether copolymer, dimethyldiallylammonium chloride/acrylamide copolymer, acrylamide/acrylic acid/dimethyldiallylammonium chloride copolymer, cellulose or derivatives thereof, Keratin and collagen or their derivatives, calcium alginate, pullulan, agar, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, oat gum, acacia gum, crystalline cellulose, arabinogalactan, Karaya gum, tragacanth gum, carob bean gum, ghatti gum, alginic acid and its salts (the salt forms include ammonium, potassium, calcium and sodium salts), propylene glycol alginate, albumin, casein, curdlan, β Glucans and β-glucan derivatives, locust bean gum, gellan gum, cassia gum, mannan, tara gum, tragacanth gum, tamarind gum, dextran, polydextrose, α-glucose, ethylhydroxyethylcellulose, carboxymethylcellulose and salts thereof (the salt form is calcium salt , and sodium salts.), enzymatically degraded sodium carboxymethylcellulose, hydroxypropylcellulose, hydroxypropyl starch, hydroxypropylmethylcellulose, methylethylcellulose, methylcellulose, hydroxypropylated epi-crosslinked starch, hydroxypropylated phosphate-crosslinked starch, amylopectin, Hydroxypropylated Phosphate Crosslinked Starch, Acetylated Adipate Crosslinked Starch, Oxidized Hydroxypropylated Epicrosslinked Starch, Acetylated Phosphate Crosslinked Starch, Acetylated Oxidized Starch, Alkali Treated Starch, Oxidized Hydroxypropylated Epicrosslinked Starch, Glycerol Crosslinked Starch , acid-treated starch, phosphate-monoesterified phosphate-crosslinked starch, phosphorylated starch, acetate starch, bleached starch, enzyme-treated starch, oxidized starch, sodium starch glycolate, sodium starch succinate, glucomannan, cyclodextrin, dextrin, Examples include pullulan, pectin, sodium polyacrylate, Eukema, β-1,3-glucan agar, and α-glucose derivatives.

A thickener and a gelatinizer may be used individually by 1 type, and may use 2 or more types together.
When the composition of the present invention contains a thickening agent and/or a gelling agent, the content of the thickening agent and the gelling agent (the total if there are multiple types) is, with respect to the total mass of the composition, 0.001 to 3% by mass is preferable, 0.001 to 2% by mass is more preferable, and 0.001 to 1% by mass is even more preferable.

<Preservative>
Preservatives are not particularly limited, but examples include benzoic acid, sodium benzoate, potassium sorbate, sodium sorbate, sorbic acid, sodium dehydroacetate, hydrogen peroxide, formic acid, ethyl formate, sodium dichlorite, propionic acid , sodium propionate, calcium propionate, pectin hydrolysate, polylysine, phenoxyethanol, thiram, thiabendazole, imazalil, diphenyl, natamycin, fludioxonil, azoxystrobin, and tea tree oil.

Preservatives may be used singly or in combination of two or more.
When the composition of the present invention contains an antiseptic, the content of the antiseptic (the total when multiple kinds are present) is preferably 0.001 to 3% by mass, based on the total mass of the composition. 001 to 2% by mass, and even more preferably 0.001 to 1% by mass.

<Perfume>
The fragrance is not particularly limited, but examples include musk, acacia oil, anise oil, ylang-ylang oil, jasmine oil, sweet orange oil, spearmint oil, geranium oil, neroli oil, peppermint oil, cypress oil, fennel oil, peppermint oil, Bergamot oil, lime oil, lavender oil, lemon oil, lemongrass oil, rose oil, rosewood oil, anisaldehyde, civetone, muscone, and limonene.

A fragrance|flavor may be used individually by 1 type, and may use 2 or more types together.
When the composition of the present invention contains a perfume, the content of the perfume (the total if there are multiple types) is preferably 0.001 to 3% by mass, preferably 0.001 to 0.001%, based on the total mass of the composition 2% by mass is more preferred, and 0.001 to 1% by mass is even more preferred.

<Pigment>
Pigments are not particularly limited, but include, for example, krill pigments, orange pigments, kaolin, sunflower, chromium oxide, iron oxide, titanium dioxide, and chlorophyll.

A dye may be used individually by 1 type, and may use 2 or more types together.
When the composition of the present invention contains a pigment, the content of the fragrance (the total if multiple types are present) is preferably 0.001 to 3% by mass, based on the total mass of the composition, and 0.001 to 2% by mass is more preferred, and 0.001 to 1% by mass is even more preferred.

[Method for producing composition]
The composition of the present invention can be prepared by appropriately mixing the essential ingredients and optional ingredients described above. The order of mixing the above components is not particularly limited.

[Dosage form]
The dosage form of the composition of the present invention is not particularly limited, and examples thereof include liquids, gels, aerosol sprays, and non-aerosol sprays.

[Use]
The composition of the present invention is preferably used as an antiviral composition, and has the effect of inactivating viruses belonging to, for example, Caliciviridae, Orthomyxoviridae, Coronaviridae, Herpesviridae, and the like. Therefore, it is preferably used for reducing the activity of the virus by acting on the virus. Examples of viruses belonging to the family Caliciviridae include viruses belonging to the genera Norovirus, Sapovirus, Lagovirus, Nebovirus, and Vesivirus. The composition of the present invention exhibits a good inactivation effect, among others, on viruses belonging to the genus Norovirus and viruses belonging to the genus Vesivirus.
Also, the composition of the present invention exhibits a good inactivation effect against microorganisms such as bacteria and fungi (eg, E. coli, Staphylococcus, etc.).

Among others, the composition is preferably used as an anti-norovirus composition.
The method of using the above composition is not particularly limited, but it can be applied or applied in advance to areas where norovirus adheres or is likely to adhere. The method of applying the composition is not particularly limited, but for example, a method of spraying the composition on the above-mentioned area, a method of wiping the above-mentioned area with a base cloth or the like containing the composition, and a method of wiping the above-mentioned area with a liquid detergent composition. A washing method and the like can be mentioned.

[spray]
The spray of the present invention includes a spray container and an antiviral composition contained in the spray container. In addition, it is as having already demonstrated as an antiviral composition.
The spray container may be an aerosol spray container or a non-aerosol spray container. As the spray container, a non-aerosol spray container is particularly preferable.
When the spray container is an aerosol spray container, for example, it is intended that the spray container contains gas such as liquid gas and compressed gas in addition to the antiviral composition. Aerosol spray containers specifically include spray containers containing gases such as liquefied petroleum gas (LPG), dimethyl ether (DME), carbon dioxide, nitrogen gas, and isopentane.
The case where the spray container is a non-aerosol spray container means that the spray container does not substantially contain gas such as liquid gas and compressed gas, and the liquid contained in the container is in the form of mist, foam, etc. A form having a mechanism for ejecting to the outside of the container is intended. Non-aerosol spray containers include, for example, pressure accumulation type spray containers such as pump type and trigger type.

[Wiper]
The wiper of the present invention includes a base fabric and an antiviral composition impregnated in the base fabric.
In addition, it is as having already demonstrated as an antiviral composition.
The base fabric is not particularly limited, and may be made of natural fibers or made of chemical fibers.
Natural fibers include, for example, pulp, cotton, hemp, flax, wool, camel, cashmere, mohair, and silk.
Chemical fibers include polyethylene terephthalate, rayon, polynosic, acetate, triacetate, nylon, polyester, polyacrylonitrile, polyvinyl alcohol, polyvinyl chloride, polyvinylidene chloride, polyethylene, polypropylene, polyurethane, polyalkylene paraoxybenzoate, and polyclar. be done.
Among these base fabrics, hydrophilic base fabrics are preferable because they are easily impregnated with the composition. A hydrophilic base fabric is, for example, a base fabric containing fibers having hydrophilic groups such as hydroxyl groups, amino groups, carboxy groups, amide groups, and sulfonyl groups. Specific examples of hydrophilic base fabrics include vegetable fibers, cotton, pulp, animal fibers, rayon, nylon, polyester, polyacrylonitrile, and polyvinyl alcohol.
As the base fabric, nonwoven fabric, cloth, towel, gauze, absorbent cotton, etc. can be used, and nonwoven fabric is preferable.

Moreover, the fabric weight (mass per unit area) of the base fabric is preferably 100 g/m ² or less. The amount of impregnation when impregnating the base fabric with the above composition is preferably at least 1 time the mass of the base fabric.

The present invention will be described in further detail based on examples below. The materials, amounts used, proportions, treatment details, treatment procedures, etc. shown in the following examples can be changed as appropriate without departing from the gist of the present invention. Therefore, the scope of the present invention should not be construed to be limited by the examples shown below.

[Antiviral composition of Example 1]
[Preparation method]
12 mL of ethanol was added to a glass container charged with 90 mg of 3-hydroxy-5-hexyloxybenzoic acid to dissolve 3-hydroxy-5-hexyloxybenzoic acid in ethanol. Next, water and a 1 mol/L sodium hydroxide aqueous solution are placed in the glass container so that the total amount of water is 18 mL (ethanol concentration of 40% by volume with respect to the total volume of the solvent), and the prepared antiviral The pH of the composition was adjusted to 10.5 to obtain an antiviral composition.
In addition, the measurement of pH was implemented by the following method.

[Measurement of pH]
Using a pH meter (product name “pH/water quality analyzer LAQUA F-72S”, manufactured by HORIBA, Ltd.) and a pH electrode (product name “6377-10D”, manufactured by HORIBA, Ltd.), pH standard solution After calibrating the pH, the measurement was performed. After the sample liquid was adjusted to a liquid temperature of 25° C., the electrode was immersed in the sample liquid and allowed to stand for about 1 to 2 minutes, and the pH value was read when the numerical value stabilized.

[Evaluation of pKa of antiviral component]
The pKa of the antiviral component was determined by the following measuring device and procedure.
<Measuring device>
Apparatus: Potentiometric automatic titrator AT-610 (manufactured by Kyoto Electronics Industry Co., Ltd.)
<Measurement method>
1 mmol of 3-hydroxy-5-hexyloxybenzoic acid was dissolved in 40 mL of ethanol, and 10 mL of purified water was added. The pKa was calculated by titrating with 1 mol/L sodium hydroxide after adding 2 mL of 1 mol/L hydrochloric acid. In 3-hydroxy-5-hexyloxybenzoic acid, the pKa derived from acid dissociation of the phenolic hydroxyl group is 12.1, and the pKa derived from acid dissociation of the carboxyl group, which is an acidic group, is 6.4. rice field.
Then, the obtained pKa was evaluated according to the following criteria.
The pKa of the antiviral component used in each example and each comparative example was also measured by the method described above and evaluated according to the following criteria.

<Evaluation Criteria>
"A": pKa derived from acid dissociation of acidic group < pKa derived from acid dissociation of phenolic hydroxyl group "B": pKa derived from acid dissociation of acidic group ≥ pKa derived from acid dissociation of phenolic hydroxyl group in the case of

[Evaluation of solubility of antiviral component]
The composition (liquid) prepared as each example and each comparative example was evaluated for the solubility of the antiviral component according to the following criteria.
<Evaluation Criteria>
"A": It became a colorless and transparent liquid and completely dissolved.
"B": It was not completely dissolved and became cloudy.
"C": Almost insoluble.

<Preparation of Antiviral Compositions of Examples 2 to 21 and Comparative Examples 1 to 4>
Antiviral compositions of Examples 2 to 21 and Comparative Examples 1 to 4 were prepared according to the preparation method of the antiviral composition of Example 1 with the component formulations and pH shown in Table 1.

〔evaluation〕
The prepared antiviral compositions of Examples 1 to 21 and Comparative Examples 1 to 4 were evaluated for antiviral activity by the method shown below.

<Evaluation of anti-feline calicivirus activity>
A virus solution obtained by culturing feline calicivirus (ATCC VR-782) in a MEM (Minimum Essential Media) medium was inoculated into the composition prepared above, and then stirred for 10 seconds, followed by about 25 seconds. ℃ for 1 minute. Next, 0.1 mL of the composition liquid after inoculation of the virus solution was collected, and 9.9 mL of SCDLP medium (Soybean. Casein Digest Agar with Lecithin and Polysorbate 80, serum added to a final concentration of 10%). ) and mixed well to obtain a test solution. Next, 0.1 mL of the test solution was inoculated into CRFK cells (cat kidney-derived cell line, ATCC CCL-94) cultured on an agar medium, and allowed to adsorb at 37° C. for 1 hour. Next, the test solution on the CRFK cells was washed away, an agar medium was overlaid, and the cells were cultured for 2 to 3 days. After culturing, the number of plaques formed was counted to calculate the infectivity titer, which was defined as the "antiviral composition infectivity titer". Infectivity titers were also calculated for specimens prepared in the same manner as described above, except that sterilized purified water was used instead of the antiviral composition, and this was used as the "control infectivity titer."
The antiviral properties (antiviral activity value) of the composition were calculated using the following formula 1, and the calculation results were evaluated using the following criteria. Table 1 shows the results.

Formula 1: Antiviral activity value = AB
A above represents the common logarithm of the infection titer of the control.
B above represents the common logarithmic value of the infection titer of the antiviral composition.

(Evaluation criteria)
"A": Antiviral activity value of 4.0 or more "B": Antiviral activity value of 3.5 or more and less than 4.0 "C": Antiviral activity value of 3.0 or more and less than 3.5 "D" : Antiviral activity value of 2.0 or more and less than 3.0 "E": Antiviral activity value of less than 2.0

In the tables below, " _oleyl " intends an unsaturated alkyl group represented by _C18H35 . Also, "2-hexyloctyl" intends a saturated alkyl group represented by C ₁₄ H ₂₉ .
In the tables below, the "relationship between the pKa of the phenolic hydroxyl group and the acidic group" means the magnitude relationship between the pKa derived from the acid dissociation of the phenolic hydroxyl group and the pKa derived from the acid dissociation of the acidic group. The evaluation criteria are as described above.
In addition, in the "pKa derived from dissociation of phenolic hydroxyl group" column in the following tables, the pKa of the compounds used in Examples 15, 18, and 21 were all ≤14.0.

From the results in Table 1, it was confirmed that the antiviral compositions of Examples exhibited excellent antiviral activity against feline calicivirus.
Further, from the comparison of Examples 1 to 3, when the number of carbon atoms in the aliphatic hydrocarbon group having 6 or more carbon atoms contained in the antiviral component in the antiviral composition is 10 or more (preferably 12 or more), It was confirmed that the antiviral composition exhibits superior antiviral activity against feline calicivirus.
Further, from a comparison of Examples 4, 11, and 12, the antiviral composition has an alcohol content of 25 to 100% by volume (preferably 30 to 100% by volume) relative to the total volume of the solvent. %), it was confirmed to exhibit superior antiviral activity against feline calicivirus.
Further, from the comparison of Example 4, Example 16, and Example 17, when the content of the specific compound is 0.05% by mass or more (preferably 0.10% by mass or more) relative to the total mass of the composition, It was confirmed to exhibit superior antiviral activity against feline calicivirus.
In addition, from the comparison of Examples 4, 13, and 14, when the pH of the composition is 9.5 or higher (preferably 10.0 or higher), the antiviral activity against feline calicivirus is superior. It was confirmed that
In addition, from the comparison between Example 4 and Example 18, when the specific compound has a structure that does not have a substituent in the vicinity of the phenolic hydroxyl group (ortho position of the phenolic hydroxyl group), it is superior to feline calicivirus. It was confirmed that it exhibited antiviral activity.
On the other hand, it is clear that the antiviral composition of the comparative example has inferior antiviral activity against feline calicivirus.

[Antiviral compositions of Examples 22 to 27 and Comparative Example 5]
[Preparation of Antiviral Compositions of Examples 22 to 27 and Comparative Example 5]
According to the preparation method of the antiviral composition of Example 1, antiviral compositions of Examples 22 to 27 were prepared with the component formulations and pH shown in Table 2.
Also, as an antiviral composition of Comparative Example 5 (not shown in the table), an aqueous sodium hypochlorite solution was prepared.

[Evaluation of Antiviral Compositions of Examples 22 to 27 and Comparative Example 5]
<Evaluation of metal corrosiveness>
About 100 mL of each antiviral composition listed in Table 2 was placed in a stainless vat, and aluminum, copper, and brass plates were immersed at room temperature under sealed conditions. After one week, each plate was taken out, and the plate surface was visually observed and evaluated according to the following criteria.

(Evaluation criteria)
"A": No change.
"B": Decrease in gloss and slight change in color were observed.
"C": Rust occurred.

In addition, anti-feline calicivirus activity was evaluated in the same manner as in Example 1 for each of the antiviral compositions of Examples 22-27.

From the results in Table 2, it was found that when the antiviral composition had a pH of 12.0 or less, almost no corrosion was observed on aluminum plates, copper, and brass.
On the other hand, when sodium hypochlorite (Comparative Example 5), which is widely used as a norovirus disinfectant, is used as an antiviral agent, there is slight corrosion (B rating) on aluminum and severe corrosion (C rating) on copper and brass. confirmed.

[Antiviral compositions of Examples 28 to 33 and Comparative Example 6]
[Preparation of Antiviral Compositions of Examples 28 to 33 and Comparative Example 6]
According to the preparation method of the antiviral composition of Example 1, antiviral compositions of Examples 28 to 33 and Comparative Example 6 were prepared with the component formulations and pH shown in Table 3.

[Evaluation of Antiviral Compositions of Examples 28 to 33 and Comparative Example 6]
<Evaluation of antiviral activity in wet wiper form>
Wiping the compositions of Examples 28 to 33 and Comparative Example 6 with reference to the "Sterilization Performance Test Method for Wet Wipes (Revised on November 16, 2015)" stipulated by the Japan Sanitary Materials Industry Association A test was conducted.
As a specific procedure, MEM (Minimum Essential Media) is used as the test carrier in accordance with the "Sterilization Performance Test Method for Wet Wipers (Revised on November 16, 2015)" stipulated by the Japan Sanitary Materials Industry Association. A virus solution obtained by culturing feline calicivirus (ATCC VR-782) in a medium was inoculated, dried, and then wiped off with a weight wrapped with a test cloth impregnated with each composition. Next, the above test carrier (stainless steel plate) was placed in 20 mL of SCDLP medium, and residual viruses were washed out from the test carrier to obtain a virus solution for specimen preparation. A virus solution for preparing a control sample was obtained in the same manner as above, except that a test cloth impregnated with sterilized purified water was used instead of the test cloth impregnated with the antiviral composition. Next, CRFK cells cultured on an agar medium were inoculated with 0.1 mL of the virus solution for specimen preparation, and adsorbed at 37° C. for 1 hour. Next, the test solution on the CRFK cells was washed away, and the cells were overlaid with an agar medium and cultured for 2 to 3 days. After culturing, the number of plaques formed on the agar medium was counted to calculate the infectious titer, which was defined as the "antiviral composition infectious titer". In addition, the infection titer was also calculated for specimens prepared in the same manner as described above, except that the virus fluid for preparing the specimen was replaced with the virus fluid for preparing the control specimen, and this was used as the "control infection titer."

Formula 2: Antiviral activity value = AB
A above represents the common logarithm of the infection titer of the control.
B above represents the common logarithm of the infectivity titer of the composition.

(Evaluation criteria)
“A”: Antiviral activity value of 2.5 or more “B”: Antiviral activity value of 2.0 or more and less than 2.5 “C”: Antiviral activity value of less than 2.0

<Evaluation of wiping variation>
Five lots of the antiviral composition shown in Table 3 were prepared using the antiviral components of the same production lot, and the antiviral activity value in the wet wiper mode was evaluated for each lot. The evaluation method conforms to the method shown in <Evaluation of antiviral activity in the form of a wet wiper> above. Then, based on the obtained virus activity value, evaluation was made according to the following evaluation criteria.

(Evaluation criteria)
“A”: The difference between the maximum and minimum antiviral activity values is less than 0.3 “B”: The difference between the maximum and minimum antiviral activity values is 0.3 or more and less than 0.5 “C” : The difference between the maximum and minimum values of antiviral activity is 0.5 or more In Table 3 below, the volume ratio of "A" and "B" ([B]/[A]) is A volume of alcohol of vol/C2 or less is intended.

From the results in Table 3, as alcohols, alcohols with 2 or less carbon atoms (e.g., ethanol or methanol) and alcohols with 3 or more carbon atoms (e.g., isopropanol, 1-butanol, or 2-pentanol) are used in combination. , It was found that the anti-feline calicivirus activity value was improved and its variation was reduced.
Alcohols with 3 or more carbon atoms (isopropanol (CLogP value: 0.0740), 1-butanol (CLogP value: 0.823), 2-pentanol (CLogP value: 1.13), etc.) are It is assumed to have higher lipid solubility and higher surfactant function than alcohols (methanol (CLogP value: -0.764), ethanol (CLogP value: -0.235)). As a result, Examples 29 to 33 in which an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms were used in combination were compared with Example 28 in which an alcohol having 2 or less carbon atoms was used alone. It is thought that the synergistic effect with the phenoxide anion formed by dissociation of hydrogen is further strengthened, the antiviral activity is improved, and viruses and stains can be physically removed.

[Antiviral compositions of Examples 34, 35 and Comparative Example 7]
[Preparation of Antiviral Compositions of Examples 34, 35, and Comparative Example 7]
According to the preparation method of the antiviral composition of Example 1, the antiviral compositions of Examples 34, 35 and Comparative Example 7 were prepared with the composition and pH shown in Table 4. In addition, content of an additive is content (mass %) with respect to the total mass of a composition.

[Evaluation of Antiviral Compositions of Examples 34, 35 and Comparative Example 7]
The antiviral compositions shown in Table 4 below were evaluated for antiviral activity in the form of a wet wiper and evaluated for wiping variability in the same manner as in Examples 28 to 33 and Comparative Example 6.

From the results in Table 4, it was found that the anti-feline calisis virus activity was improved and its variation was small when the antiviral composition contained a surfactant.

[Antiviral compositions of Examples 36 to 39]
[Preparation of Antiviral Compositions of Examples 36 to 39]
According to the preparation method of the antiviral composition of Example 1, antiviral compositions of Examples 36 to 39 were prepared with the component formulations and pH shown in Table 5. In addition, content of an additive is content (mass %) with respect to the total mass of a composition.

[Evaluation of Antiviral Compositions of Examples 36 to 39]
The antiviral compositions shown in Table 5 below were evaluated for antiviral activity in the form of a wet wiper and evaluated for wiping variability in the same manner as in Examples 28 to 33 and Comparative Example 6.

From the results in Table 5, it was found that anti-feline calisis virus activity was improved and its variation was small when the antiviral composition contained a quaternary ammonium salt.

[Antiviral compositions of Examples 40 to 42]
[Preparation of Antiviral Compositions of Examples 40 to 42]
According to the preparation method of the antiviral composition of Example 1, antiviral compositions of Examples 40 to 42 were prepared with the component formulations and pH shown in Table 6.

[Evaluation of Antiviral Compositions of Examples 40 to 42]
The antiviral compositions shown in Table 6 were evaluated for activity against influenza virus and general bacteria.
<Evaluation of anti-influenza virus activity>
After inoculating a virus solution obtained by culturing an influenza virus (Influenza A virus (H3N2): ATCC VR-1679) in a MEM (Minimum Essential Media) medium into the composition prepared above, stirring for 10 seconds, It was allowed to stand at about 25°C for 1 minute. Next, 0.1 mL of the composition after the inoculation of the virus solution was collected and put into 9.9 mL of SCDLP medium (Soybean-Casein Digest Broth with Lecithin & Polysorbate 80) and mixed well to obtain a test solution. Next, MDCK cells (cells derived from canine renal tubular epithelium, ATCC CCL-34) cultured on an agar medium were inoculated with 0.1 mL of the test solution and allowed to adsorb at 34° C. for 1 hour. Next, the test solution on the MDCK cells was washed away, and the cells were overlaid with an agar medium and cultured for 2 to 3 days. After culturing, the number of plaques formed on the agar medium was counted to calculate the infectivity titer, which was defined as the "composition infectivity titer". The infectivity titer was also calculated for a specimen prepared in the same manner as described above except that sterilized purified water was used instead of the composition, and this was used as the "control infectivity titer".
Calculation and evaluation of the antiviral activity value were performed in the same manner as the evaluation of the anti-feline calicivirus activity in Example 1.
Table 6 shows the results.

<Sterilization (E.coli/Staphylococcus aureus)>
The test was conducted using the "Sterilization Activity Test Method for Household Synthetic Detergents and Soaps" stipulated by the Detergent and Soap Fair Trade Council. The bacterial strains used in the test were Escherichia coli NBRC 3972 and Staphylococcus aureus NBRC 12732. Calculation and evaluation of the antibacterial activity value were performed in the same manner as the evaluation of the anti-feline calicivirus activity in Example 1.

From the results in Table 6, it was found that the antiviral composition of the present invention exhibited excellent antibacterial activity against influenza viruses and bacteria.

Claims (16)

A compound represented by the following formula (1-7) or the following formula (1-9 ) .

In formula (1-7), L ^5B represents -O - . R ⁵ represents an aliphatic hydrocarbon group having 9 to 30 carbon atoms .
In formula (1-9), L ^7B represents a divalent linking group selected from the group consisting of —O—, —COO— and —CONR ^x4 —. R ^X4 represents a hydrogen atom . When L ^7B represents —O—, R ⁷ represents an aliphatic hydrocarbon group having 11 to 30 carbon atoms. When L ^7B represents -COO-, R ⁷ represents an aliphatic hydrocarbon group having 6 to 30 carbon atoms. When L ^7B represents —CONR ^x4 —, R ⁷ represents a linear or branched aliphatic hydrocarbon group having 6 to 30 carbon atoms. a compound of claim 1;
a solvent comprising an alcohol;
An antiviral composition having a pH of 9.0 to 14.0. 3. The antiviral composition according to claim 2, wherein R5 or ^R7 has ¹² or more carbon atoms. 4. The antiviral composition according to claim 2 or 3, wherein the compound according to claim 1 has a phenolic hydroxyl group with a pKa of 11.0 or more. The antiviral composition according to any one of claims 2 to 4, wherein the alcohol content is 25 to 100% by volume relative to the total volume of the solvent. The antiviral composition according to any one of claims 2 to 5, wherein the alcohol includes an alcohol having 2 or less carbon atoms and an alcohol having 3 or more carbon atoms. 7. The antiviral composition according to claim 6, wherein said alcohol having 2 or less carbon atoms comprises ethanol and said alcohol having 3 or more carbon atoms comprises isopropanol. The antiviral composition according to any one of claims 2 to 7, further comprising a surfactant. The antiviral composition according to any one of claims 2 to 8, further comprising a quaternary ammonium salt. The antiviral composition according to any one of claims 2 to 9, wherein the content of the compound according to claim 1 is 0.10% by mass or more relative to the total mass of the composition. The antiviral composition according to any one of claims 2 to 10, which has a pH of 10.0 to 12.0. The antiviral composition according to any one of claims 2 to 11, which is a liquid formulation. The antiviral composition according to any one of claims 2 to 11, which is a gel. An anti-norovirus composition comprising the antiviral composition according to any one of claims 2 to 13. A spray comprising a spray container and the antiviral composition according to any one of claims 2 to 13 or the anti-norovirus composition according to claim 14 contained in the spray container. A wiper comprising a base fabric and the antiviral composition according to any one of claims 2 to 13 or the anti-norovirus composition according to claim 14 impregnated in the base fabric.