WO2020035767A1 - Instrument de laboratoire pour tester un échantillon de patient - Google Patents
Instrument de laboratoire pour tester un échantillon de patient Download PDFInfo
- Publication number
- WO2020035767A1 WO2020035767A1 PCT/IB2019/056756 IB2019056756W WO2020035767A1 WO 2020035767 A1 WO2020035767 A1 WO 2020035767A1 IB 2019056756 W IB2019056756 W IB 2019056756W WO 2020035767 A1 WO2020035767 A1 WO 2020035767A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- reagent
- pipetting
- laboratory instrument
- carousel
- pins
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N35/1016—Control of the volume dispensed or introduced
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1065—Multiple transfer devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0401—Sample carriers, cuvettes or reaction vessels
- G01N2035/0429—Sample carriers adapted for special purposes
- G01N2035/0436—Sample carriers adapted for special purposes with pre-packaged reagents, i.e. test-packs
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
- G01N2035/0439—Rotary sample carriers, i.e. carousels
- G01N2035/0443—Rotary sample carriers, i.e. carousels for reagents
Definitions
- TITLE LABORATORY INSTRUMENT FOR TESTING PATIENT SAMPLE
- the present disclosure relates in general to laboratory instruments for testing patient sample.
- immunoassay analyzers may be used for testing a patient sample for infectious diseases, allergies, cardiac markers, endocrine hormone, protein, presence of viral or bacterial substances, and toxin determinations. Immunoassay analyzer may be also used for antiarrhythmic, antibiotic, anticonvulsant, or cardiac glycoside drug concentration determination.
- immunoassay analyzers usually involve analysing patient samples with the use of suitable reagents based on a test required.
- reagents are stored in containers/ reagent packs and are placed in reagent carousels in an immunoassay analyser.
- patient samples are stored on containers/test tubes and are placed in sample carousels in an immunoassay analyser.
- Conventional analyzers like normally use a common pipette for aspirating the patient sample and reagents. The aspirated patient sample and reagent are dispensed in a reaction vessel present in the analyzer, for performing the test.
- quality of results from immunoassay analyzers may be dependent on various factors and can be influenced by contamination of the pipette. Since the conventional analyzers have a common pipette for aspirating both the patient sample and the reagent, the pipette may carryover patient sample and/or reagents for a subsequent test. When the pipette is drawing from a reagent pack comprising the sample of the previous test, the reagent may be contaminated and thus lead to several issues including reducing the life of the reagent pack.
- level sensors for e.g., ultrasound sensors
- the pipette aspirates the reagent.
- the level sensors fail to operate properly and do not detect the presence of reagents inside the reagent packs. Thus, reagent packs are discarded due to improper working of the level sensors.
- pipetting units are prone to damages due to collision with the reagent packs and replacing the pipetting units may be an expensive process.
- the present disclosure discloses a laboratory instrument (also referred as immunoassay analyzer) for performing tests on patient samples.
- the laboratory instrument comprises a sensor communicatively coupled to a computing system to detect insertion of a container (generally referred as a reagent pack) in a carousel of the laboratory instrument.
- the sensor may also detect when the container (reagent pack) is replaced.
- the sensor can include but is not limited to a weight sensor, an Infra-Red (IR) sensor or any other sensor that is capable of detecting insertion of the container/ reagent pack into the carousel.
- the computing system can be used to initiate a test.
- a laboratory technician generally operates the computing system.
- the laboratory technician places a plurality of patient samples and the reagent packs comprising chemical substance in respective carousels (reagent packs are placed in a reagent carousel and patient sample is placed in a sample carousel).
- the laboratory technician may select a test to be performed on a patient sample, using the computing system. Thereafter, the computing system configures the laboratory instrument to perform the test on a selected patient sample.
- the selected patient sample and appropriate chemical substances from reagent packs are aspirated and are dispensed into a reaction vessel. The reaction vessel is used to mix the patient sample and the chemical substance. The mixture is then observed and analysed for performing the test.
- the laboratory instrument comprises one or more pipetting pins configured for piercing the reagent packs placed in the reagent carousel.
- the reagent carousel comprises the one or more pipetting pins.
- the laboratory instrument also comprises one or more tubes (also referred as pipes), where one end of each tube connected to a pipetting pin. Other end of each tube terminates at the reaction vessel.
- the aspirated chemical substance present in the reagent packs is transported to the reaction vessel by corresponding channels.
- the one or more pipetting pins and the corresponding tubes are referred as pipetting lines.
- each reagent pack may be provided with pipetting line.
- one pipetting line may be provided in the laboratory instrument and the reagent carousel may be rotated such that the selected reagent pack is positioned along the pipetting line which enables the plurality of pipetting to aspirate predefined amount of the chemical substances from the reagent packs.
- the patient sample is dispensed in to the reaction vessel using the one or more tube of the pipetting line.
- the dispensed chemical substance and the patient sample are mixed in the reaction vessel to facilitate testing of the patient sample.
- the one or more pipetting pins may be attached to a bottom surface of the reagent carousel.
- the one or more pipetting pins can be attached to any surface of the reagent carousel.
- the reagent packs may be placed inverted in the reagent carousel, for the one or more pipetting pins to aspirate the chemical substance present in the reagent pack.
- the computing device is configured to operate the laboratory instrument for performing tests on patient samples.
- the computing device may be communicatively connected to the laboratory instrument.
- the computing device is configured to receive inputs from a sensor in the laboratory instrument for performing a test/ several tests on a patient sample.
- the inputs may include name/ identity of patient sample, and names of the tests to be performed.
- the computing device may detect insertion of reagent packs and patient sample in the respective carousels.
- the computing device may use sensors for detecting the insertion of the reagent packs and patient sample.
- the computing device provides the pipetting line of the laboratory instrument with instructions to aspirate the chemical substance present in each compartment of the reagent packs and dispense the aspirated chemical substance into the reaction vessel.
- the computing device operates the pipetting line to aspirate a predefined amount of sample from each compartment.
- the computing device may operate actuators associated with the pipetting line for aspirating and dispensing the chemical substance.
- Figure 1 illustrates an exemplary diagram of a laboratory set-up for performing immunoassay analysis, in accordance with embodiments of the present disclosure
- Figure 2 illustrate simplified diagram of internal structure of a laboratory instrument for performing immunoassay analysis, in accordance with embodiments of the present disclosure
- Figure 3 illustrates an exemplary container for holding chemical substance, in accordance with embodiments of the present disclosure
- Figure 4 illustrates an exemplary container for holding patient sample, in accordance with an embodiment of the present disclosure.
- Figure 5 shows an exemplary diagram illustrating aspiration of chemical substance from a container, in accordance with an embodiment of the present disclosure.
- an embodiment means “one or more (but not all) embodiments of the disclosure(s)" unless expressly specified otherwise.
- a laboratory instrument for performing tests on patient samples is disclosed.
- the laboratory instrument is also referred as immunoassay analyzer in the present disclosure.
- the laboratory instrument comprises a reagent carousel to hold a plurality of containers (generally referred as reagent packs) comprising chemical substance.
- the reagent packs comprise compartments (a typical reagent pack may comprise five compartments).
- each compartment comprises a unique chemical substance.
- each compartment of the reagent pack has an opening provided for aspirating the chemical substance.
- the opening is covered with an elastomer material.
- the elastomer can be pierced by a pipette/ pipetting pin of a pipetting line for aspirating the chemical substance.
- the opening can be covered with any other suitable material.
- the reagent packs are inserted/ placed into the reagent carousel by a laboratory technician.
- the reagent carousel comprises one or more sensors to detect insertion of the reagent packs into the reagent carousel.
- the one or more sensors are placed in the laboratory instrument.
- the one or more sensors may be connected to the computing device via a wireless or a wired interface.
- the computing device may control the one or more sensors using software modules.
- the one or more sensors can include but is not limited to a weight sensor, an IR sensor, or any sensor that is capable for detecting insertion of the reagent pack in the reagent carousel.
- a weight sensor can be mounted at a bottom surface of the reagent carousel.
- the weight sensor can sense the insertion and indicate the lab technician.
- the one or more sensors are configured to detect replacement of a reagent pack.
- the one or more sensors can provide an indication to the lab technician upon detecting the insertion of the reagent pack.
- the indication can be displayed on a monitor of a computing system communicatively coupled with the laboratory instrument.
- the laboratory instrument comprises a sample carousel for holding one or more patient samples.
- the one or more patient samples are placed in one or more containers (generally referred as test tubes).
- the one or more test tubes are placed in the laboratory instrument by the laboratory technician.
- the one or more sensors can be mounted in the sample carousel as well.
- the one or more sensors can also be used to detect insertion/ replacement of the one or more test tubes into the sample carousel.
- Figure 1 illustrates exemplary diagram of a laboratory set-up for performing immunoassay analysis.
- Figure 1 shows laboratory instrument (101), computer system (102) and a cable (103) connecting laboratory instrument (101) to computing system (102).
- laboratory instrument (101) is an immunoassay analyzer.
- Computing system (102) is used to operate laboratory instrument (101).
- the computing system ( 102) is provided with inputs by the laboratory technician for performing the tests on the patient samples.
- computing system (102) displays a message on a display associated with computing system (102), confirming successful insertion.
- the reagent carousel and the sample carousels comprise a plurality of slots to hold the reagent pack and the patient samples.
- each slot is provided with a unique identity.
- the reagent pack and the patient samples are identified by the identity of the slots in which they are inserted.
- a sensor from one or more sensor is mounted in each slot of the reagent carousel/ sample carousel.
- the sensor present in the slot detects the insertion and communicates to computing device (102).
- Computing device (102) detects that the reagent pack has been placed in the carousel and further operates the laboratory instrument (101) for performing tests on the patient sample.
- the one or more sensors are placed in the laboratory instrument.
- the one or more sensors may be connected to the computing device via a wireless or a wired interface.
- the computing device may control the one or more sensors using software modules.
- a wireless module may be integrated with the computing device and the one or more sensors.
- a transmitter module may be present at the computing device end and a receiver module may be present at the sensor end.
- the computing device can communicate, for example provide instructions to the one or more sensors via the transmitter module and the receiver module can receive the instructions.
- the one or more sensors then operates according to the instructions.
- the one or more sensors can have the transmitter module and the computing device can have the receiver module.
- the one or more sensors detect the insertion of the reagent pack into the reagent carousel and transmits the detection via the transmitter module.
- the receiver module receives the information and the computing unit determines the insertion of the reagent pack into the reagent carousel.
- both of the one or more sensors and the computing device can have a transceiver module for establishing communication.
- the laboratory technician uses computing system (102) to initiate a test on a patient sample.
- the laboratory technician selects specific patient sample using the unique identity of the slot into which the patient sample is inserted.
- the laboratory technician selects the test/ tests to be performed on the selected patient sample.
- the reagents/ chemical substances to be used are predefined, and computing system (102) may display the reagents/ chemical substances to the laboratory technician.
- computing system (102) operates laboratory instrument
- computing system (101) by providing signals via cable (103).
- computing system (102) instructs laboratory instrument (101) to aspirate a 5ml of the patient sample from a test tube placed in a specific slot in the sample carousel and dispense it in a reaction vessel.
- computing system (102) instructs laboratory instrument ( 101 ) to aspirate a 2ml of the chemical substance from a reagent pack placed in a specific slot in the sample carousel and dispense it in a reaction vessel.
- laboratory instrument (101) is connected to the computing system
- connection protocols including, without limitation, direct connect, Ethernet (e.g., twisted pair 10/100/1000 Base T), transmission control protocol/Intemet protocol (TCP/IP), token ring, IEEE 802.1 la/b/g/n/x, etc.
- communication network 104 may include, without limitation, a direct interconnection, wired connection, e-commerce network, a peer to peer (P2P) network, Local Area Network (LAN), Wide Area Network (WAN), wireless network (e.g., using Wireless Application Protocol (WAP)), the Internet, Wireless Fidelity (Wi-Fi), etc.
- P2P peer to peer
- LAN Local Area Network
- WAN Wide Area Network
- WAP Wireless Application Protocol
- Wi-Fi Wireless Fidelity
- FIG. 1 illustrates a simplified diagram of internal structure of laboratory instrument (101) for performing immunoassay analysis.
- laboratory instrument (101) comprises the reagent carousel (201), a sample carousel (202), one or more reagent packs (203) comprising the chemical substance, one or more test tubes (204) comprising the patient samples, one or more tubes (205), a reaction vessel (206) and a conventional pipetting system (207).
- Reagent carousel (201) is configured to hold the one or more reagent packs (203).
- Reagent carousel (201) comprises the one or more sensors (not shown in figure) for detecting insertion of one or more reagent packs (203).
- the sensors configured to detect insertion of the reagent packs (203) is also referred as first set of sensors.
- reagent carousel (201) comprises a plurality of slots, each slot configured to hold one reagent pack (203). Each slot is associated with the unique identity. When a reagent pack (203) is inserted into a slot, reagent pack (203) is associated with the unique identity of the slot into which it is inserted.
- the unique identity is used to detect if the specific reagent pack required for performing the test is inserted into the slot.
- the computing device ( 102) Upon detecting the insertion of the specific reagent pack, the computing device ( 102) operates the laboratory instrument ( 101 ) to aspirate chemical substance from specific reagent pack (203).
- sample carousel (202) is configured to hold one or more test tubes (204) comprising the patient sample.
- Sample carousel (202) may comprise the one or more sensors (not shown in figure) for detecting insertion of one or more test tubes (204).
- sample carousel (202) comprises a plurality of slots, each slot configured to hold one test tube (204). Each slot is associated with the unique identity.
- test tube (204) is inserted into a slot, test tube (204) is associated with the unique identity of the slot into which it is inserted.
- the specific patient sample to be tested is placed in the dedicated slot.
- the identity associated with the dedicated slot is registered in the computing device (102).
- the computing device (102) operates the laboratory instrument (101) for pipetting predefined amount of sample from the specific patient sample.
- the laboratory instrument (101) may comprise a plurality of reaction vessels (206).
- the test may be performed on the patient sample only when all the reaction vessels are filled with the specific patient sample and appropriate reagents.
- Figure 3 illustrates a typical reagent pack (203) used in laboratory instrument (101).
- Reagent pack (203) as shown in Figure 3 comprises five compartments (301A, 301B, 301C, 301D and 301E).
- each compartment comprises a unique chemical substance.
- each compartment has an opening on a surface, masked by an elastomer layer. Any material can be used to mask the opening in each compartment.
- the elastomer layer is provided to secure the chemical substance present inside each compartment during transportation of reagent pack (203). Also, the elastomer can be easily pierced by a pipette. In an embodiment, the opening is provided in a top surface or a bottom surface of reagent pack (203). In one embodiment, each compartment is isolated thermally and chemically.
- Figure 4 shows atypical test tube used in laboratory instrument (101) for performing tests.
- Figure 5 illustrates an exemplary diagram for aspirating chemical substance from reagent packs (203).
- reagent packs (203) are placed inverted in reagent carousel (201) such that the openings in each compartment face the bottom surface of reagent carousel (201).
- lab instrument (101) comprises one or more pipetting pins (501) configured for piercing reagent packs (203) placed inverted in reagent carousel (201).
- pipetting pins (501) are attached to reagent pack (203) to pierce the elastomer in each compartment to aspirate the chemical substance present in each compartment.
- one or more pipetting pins (501) may extend from a bottom surface of reagent carousel (201).
- the pipetting pins (501) are configured to pipette the chemical substance from the reagent pack (203).
- the pipetting pins (501) work on the principle of suction.
- the reagent carousel (201) comprises a mechanism to push the pipetting pins into an opening on the top of the reagent pack (203).
- each slot of reagent carousel (201) may comprise one or more pipetting pins (501) such that each reagent pack (203) placed in its slot has corresponding pipetting pins (501).
- the reagent carousel (201) may comprises one or more pipetting pins (501) common to each reagent pack (203). When a reagent pack (203) is selected, the reagent carousel (201) rotates to align the selected reagent pack (203) with the one or more pipetting pins (501).
- laboratory instrument (101) comprises a first mechanism to push reagent packs (203) towards the bottom surface of reagent carousel (201).
- the first mechanism is used to press the reagent pack (203) against one or more pipetting pins (501) such that one or more pipetting pins (501) pierce reagent pack (203).
- a weight may be used to press the reagent pack (203) against the one or more pipetting pins (501).
- an actuator comprising an arm may be used to apply force on the bottom surface of the reagent pack (203) which is placed inverted for pressing the reagent pack (203) against the one or more pipetting pins (501).
- one or more pipetting pins (501) pierce the reagent pack (203)
- a pressure is created inside the reagent pack (203) and the chemical substance flows into one or more pipetting pipes (501).
- one or more pipetting pins (501) are manufactured from polypropylene.
- a person of ordinary skill in the art may acknowledge that any existing pipetting materials can be used to manufacture one or more pipetting pins (501).
- a second mechanism for regulating flow of the chemical substance into one or more pipetting pins (501) a second mechanism is used.
- the second mechanism can include a combination of a second set of sensors and actuators and a control unit.
- the second set of sensors measures the rate of aspiration/ rate of flow of chemical substance into one or more pipetting pins (501).
- the control unit regulates rate of aspiration of the chemical substance into one or more pipetting pins (501) by operating the second set of actuators.
- the amount of aspiration of the chemical substance can be set using the computing system (102).
- the aspiration rate for every test can be set as 5ml.
- first set of sensors can include a flow rate sensor and the first actuator can include a valve.
- the sensor and the actuator may not be limited to the examples provided in this disclosure.
- the second mechanism may be combination of software, hardware and firmware.
- laboratory instrument (101) comprises one or more tubes (205) for dispensing the aspirated chemical substance into reaction vessel (206).
- One end of each tube (205) is attached to a corresponding pipetting pin (501). Other end of each tube (205) terminates at the reaction vessel (206).
- the aspirated chemical substance from reagent pack (203) flows through the tube (205) and is dispensed in the reaction vessel (206).
- athird mechanism is used to regulate flow of the chemical substance through the tube (205).
- the third mechanism may include a third set of sensors and actuators for regulating the flow of the chemical substance.
- the third set of sensors may include flow rate sensor and the third set of actuators may include a valve.
- the third set of sensors and actuators are operated by the control unit.
- the control unit is the computing device (102).
- the control unit can be any electronic device like a tablet, a mobile, a Personal Digital Assistant (PDA) and the like.
- the aspirated chemical substance is dispensed into the reaction vessel (206).
- one or more tubes (205) may be pipes.
- the inner surface of the pipes are non-sticky pipes so that the aspirated chemical substance does not stick to the inner surface.
- the pipes are non -reactive with the aspirated chemical substance.
- pipes are provided with non-sticky coatings.
- pipes are manufactured using materials exhibiting non-sticky characteristics. Dimension of the pipes may be varied based on requirement and type of laboratory instrument is used.
- one end of each tube (205) is detachably attached to a corresponding pipetting pin (501).
- one end of each tube (205) is permanently attached to a corresponding pipetting pin (501).
- one or more pipetting pins (501) and one or more tubes (205) are rinsed after every test.
- one or more pipetting pins (501) and one or more tubes (205) are cleansed with bleach and then rinsed with water for decontaminating the pipetting pins (501) and tubes (205).
- the conventional pipetting system (207) comprises a pipette connected to a slider. As shown, the pipette is suspended from the slider.
- the slider facilitates movement of the pipette in at least two axes. For example, the slider may move the pipette in a horizontal direction and a vertical direction.
- the conventional pipetting system (207) is used for aspirating the patient sample from the selected test tube (204).
- the sample carousel (202) rotates such that the pipette is enabled to aspirate the patient sample from the test tube (204).
- the vertical axis movement of the pipette facilitates pipetting the patient sample from the selected test tube (204).
- the horizontal movement of the pipette facilitates transporting of the pipette to the reaction vessel (206).
- the pipette is configured to dispense the aspirated patient sample into the reaction vessel (206).
- the patient sample is mixed with the chemical substance in the reaction vessel (206).
- the mixture is observed and analyzed for performing the test.
- the result of the test may be displayed on the display associated with the computing system (102).
- the laboratory instrument (101) disclosed herein reduces contamination of chemical substance in the reagent pack (203). Thus, life of reagent pack (203) is preserved.
- the sample carryover is eliminated in the pipette, thus reducing false-positives in the tests performed on patient samples.
- discarding reagent packs (203) are reduced.
- each reagent pack (203) is used effectively.
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Abstract
La présente invention concerne un instrument de laboratoire pour tester des échantillons de patient, qui comprend un capteur couplé en communication à un système informatique configuré pour détecter l'insertion d'un récipient dans un carrousel de réaction. Le système informatique commande le fonctionnement de l'instrument de laboratoire pour effectuer un test sur un échantillon de patient. L'instrument de laboratoire comprend une ou plusieurs broches de pipetage conçues pour percer au moins un récipient placé dans le carrousel et conçue pour aspirer une quantité prédéfinie de substance chimique stockée dans le récipient. L'instrument de laboratoire comprend en outre un ou plusieurs tubes pour distribuer la substance chimique aspirée dans un récipient de réaction. La substance chimique distribuée est mélangée avec un échantillon de patient dans le récipient de réaction pour faciliter le test des échantillons de patient.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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IN201841030399 | 2018-08-13 | ||
IN201841030399 | 2018-08-13 |
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WO2020035767A1 true WO2020035767A1 (fr) | 2020-02-20 |
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PCT/IB2019/056756 WO2020035767A1 (fr) | 2018-08-13 | 2019-08-08 | Instrument de laboratoire pour tester un échantillon de patient |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4134964A1 (fr) * | 2021-08-11 | 2023-02-15 | Beckman Coulter Inc. | Procédé mis en uvre par ordinateur dans le domaine des tests cliniques d'échantillons biologiques |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6193933B1 (en) * | 1997-10-27 | 2001-02-27 | Hitachi, Ltd. | Automatic analysis apparatus |
DE102011002571A1 (de) * | 2011-01-12 | 2012-07-12 | Robert Bosch Gmbh | Reagenzienkartusche, Prozessier-Chip, Analyse-Kit damit und Analyseverfahren |
US20170203297A1 (en) * | 2014-12-31 | 2017-07-20 | Click Diagnostics, Inc. | Devices and methods for molecular diagnostic testing |
US9889447B2 (en) * | 2013-07-26 | 2018-02-13 | Sekisui Medical Co. , Ltd. | Reagent supplying device |
EP3301454A1 (fr) * | 2016-10-03 | 2018-04-04 | Accelerate Diagnostics, Inc. | Instrument et système d'identification rapide de micro-organismes et de test de susceptibilité d'agent antimicrobien |
-
2019
- 2019-08-08 WO PCT/IB2019/056756 patent/WO2020035767A1/fr active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6193933B1 (en) * | 1997-10-27 | 2001-02-27 | Hitachi, Ltd. | Automatic analysis apparatus |
DE102011002571A1 (de) * | 2011-01-12 | 2012-07-12 | Robert Bosch Gmbh | Reagenzienkartusche, Prozessier-Chip, Analyse-Kit damit und Analyseverfahren |
US9889447B2 (en) * | 2013-07-26 | 2018-02-13 | Sekisui Medical Co. , Ltd. | Reagent supplying device |
US20170203297A1 (en) * | 2014-12-31 | 2017-07-20 | Click Diagnostics, Inc. | Devices and methods for molecular diagnostic testing |
EP3301454A1 (fr) * | 2016-10-03 | 2018-04-04 | Accelerate Diagnostics, Inc. | Instrument et système d'identification rapide de micro-organismes et de test de susceptibilité d'agent antimicrobien |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4134964A1 (fr) * | 2021-08-11 | 2023-02-15 | Beckman Coulter Inc. | Procédé mis en uvre par ordinateur dans le domaine des tests cliniques d'échantillons biologiques |
WO2023017361A1 (fr) * | 2021-08-11 | 2023-02-16 | Beckman Coulter, Inc. | Procédé mis en œuvre par ordinateur dans le domaine des tests cliniques d'échantillons biologiques |
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