WO2020035115A1 - Tampon - Google Patents

Tampon Download PDF

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Publication number
WO2020035115A1
WO2020035115A1 PCT/DE2019/100742 DE2019100742W WO2020035115A1 WO 2020035115 A1 WO2020035115 A1 WO 2020035115A1 DE 2019100742 W DE2019100742 W DE 2019100742W WO 2020035115 A1 WO2020035115 A1 WO 2020035115A1
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WO
WIPO (PCT)
Prior art keywords
salt
magnesium
tampon
active ingredient
tampon according
Prior art date
Application number
PCT/DE2019/100742
Other languages
German (de)
English (en)
Inventor
Verena Jäger
Original Assignee
Jaeger Verena
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jaeger Verena filed Critical Jaeger Verena
Priority to DE112019004134.7T priority Critical patent/DE112019004134A5/de
Priority to EP19765645.7A priority patent/EP3836948A1/fr
Publication of WO2020035115A1 publication Critical patent/WO2020035115A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
    • A61F13/20—Tampons, e.g. catamenial tampons; Accessories therefor
    • A61F13/2074—Tampons, e.g. catamenial tampons; Accessories therefor impregnated with hydrophobic, hydrophilic, skin enhancers, medicinal etc. substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Definitions

  • the present invention relates to a tampon comprising at least one active ingredient for preventing or ameliorating dysmenorrhea.
  • naturopathic active ingredients for oral administration in the form of tablets are naturopathic active ingredients for oral administration in the form of tablets.
  • Globulis or teas are also known as hip baths for vaginal use.
  • European patent EP 1 455 847 B1 discloses a tampon which is suitable for delivering a therapeutic agent.
  • the tampon contains an absorbent material and a formulation with a therapeutically active agent.
  • the therapeutically active agent is a herbal agent which is applied to an outer layer of the tampon. Agnus castus, aloe vera, comfrey, marigold, dong quai, bugweed, chamomile, evening primrose, hypericum perforatum, licorice root, currant seed oil, St. John's wort, tea extract, lemon balm capsicum, rosemary, areca catechu, mung bean, boramel corn oil, hamamel seed oil Lavender and soy revealed.
  • the herbal composition can include green tea leaves, Sophora flavescens, mugwort
  • 2006/0147341 A1 discloses a vaginal tampon device with a mucoadhesive composition.
  • the mucoadhesive summary can also comprise botanical active ingredients, these being from Agnus castus, Aloe Vera, Comfrey,
  • Calendula dong quai, black cohosh, chamomile, evening primrose, Hypericum perforatum, black currant, seed oil, St. John's wort, tea extract, Lemon balm, bell pepper, rosemary, areca catechu, mung beans, borage seed oil, witch hazel, fenugreek, lavender, soy, vaccinium extract, heather, azaleas, red onions, root extract, capsanthin and capsaicin.
  • US patent application US 2002/0010447 A1 discloses a fibrous, absorbent article for absorbing body fluids, e.g. a tampon comprising one or more materials that can absorb odors.
  • the present invention is therefore based on the object of providing a tampon which has the following advantageous properties:
  • vaginal infections which are often promoted by drying out of the vagina when using tampons, can also be caused by the active ingredients
  • menstrual cycle is regulated naturally and may even be shortened.
  • the other primary menstrual complaints such as abdominal and back pain, diarrhea, headache, nausea etc. are also treated with the tampon during vaginal use.
  • the user can use the tampons without changing their user behavior, as they are used in a similar way to regular tampons.
  • a treatment of menstrual cramps that may have been carried out in parallel using tablets,
  • the present invention therefore relates to a tampon.
  • the tampon can be an active ingredient for preventing or alleviating
  • a tampon is understood to be any suitable feminine hygiene tampon.
  • the tampon usually includes at least one
  • Pad core and a pad cover are preferably suitable for the relief of menstrual cramps, especially dysmenorrhea.
  • the components of the active ingredients penetrate the tissue through the mucous membrane of the vagina and develop their biological effectiveness there. An absorption through the gastrointestinal tract and the high combination of active substances in the body which is necessarily associated with a systemic effect can thus advantageously be avoided.
  • the active ingredient for preventing or alleviating dysmenorrhea can be introduced into the tampon so that it is absorbed directly by the vaginal mucosa and can therefore optimally develop its effect in the local area of application.
  • the active substance can preferably be contained in the tampon core. Alternatively or additionally, the active ingredient can also be contained in the tampon cover.
  • active ingredients can be used as active ingredient (ie phytotherapeutic active ingredients according to point 1.): Chaste tree (Vitex agnus castus), St. John's wort, (Hypericum), yarrow (Achillea), lady's mantle (alchemilla vulgaris, alchemilla alpina, alchemilla xanthochlora) ), Lemon balm (Melissa officinalis), gooseberries (Argentina anserina), chamomile flowers (Matricaria chamomilla L.,), black cohosh (Actaea racemosa, Cimicifuga racemosa), evening primrose oil (Oenothera biennis), nettle (Urtica), bishop's herb (amniocha visa) (Juniperus), shepherd's purse (Capsella), Devil's claw (Harpagophytum procumbens), coconut oil or coconut oil, also called coconut fat, large-fruity cranberry /
  • Tampon material can be combined well and efficiently regulates the menstrual cycle in a natural way and, if necessary, even shortens it.
  • one or more of the following active ingredients can be used as active ingredient: chaste tree (Vitex agnus-castus), St. John's wort (Hypericum perforatum), sheep administration (Achillea millefolium), lady's mantle (Alchemilla diversa), lemon balm (Melissa officinalis), goose gingerweed (Argentina anserina )
  • active ingredient chaste tree (Vitex agnus-castus), St. John's wort (Hypericum perforatum), sheep administration (Achillea millefolium), lady's mantle (Alchemilla diversa), lemon balm (Melissa officinalis), goose gingerweed (Argentina anserina )
  • Chamomile flowers (Matricaria chamomilla L.), black cohosh (Actaea racemosa), evening primrose oil (Oenothera biennis), nettle (Urtica), juniper (Juniperus), bishop's herb (amni visnaga), shepherd's purse (Capsella bursa-pastoris),
  • the active ingredient can preferably consist of two
  • Active substance mixtures are selected: Active substance mixture at
  • the tampon comprises one or more homeopathic active ingredients as an active ingredient.
  • one or more of the following can preferably be used as homeopathic active ingredients
  • homeopathic active ingredients are used: Cimifuga, Pulsatilla, Colocynthis, Chamomilla, Agnus castus, Belladonna, magnesium phoshoricum or Calcium phosporicum.
  • the active ingredient is a tannin of
  • the tanning agent preferably has agrimoniin as
  • Active ingredient is a flavonoid. If the active ingredient is selected from these groups of substances, the tampon has an excellent pain-relieving property in combination with very good storage stability.
  • the active ingredient is a drug, i.e. a dried one
  • the active ingredient can be dried, powdered leaves of lady's mantle (Alchemilla xanthochlora).
  • the drug is selected from the group of drugs including chaste tree (Vitex agnus-castus), St. John's wort (Hypericum perforatum), sheep administration (Achillea millefolium), lady's mantle (Alchemilla diversa), lemon balm (Melissa officinalis), goose finger herb (Argentina anserina), Chamomile flowers (Matricaria chamomilla L.), black cohosh (Actaea racemosa), evening primrose oil (Oenothera biennis), nettle (Urtica), juniper (Juniperus), bishop's herb (amni visnaga), shepherd's purse (Capsella bursa-pastoris), devil's claw
  • drugs including chaste tree (Vitex agnus-castus), St. John's wort (Hypericum perforatum), sheep administration (Achillea millefolium), lady's mantle (Alchem
  • the tampon comprises a mineral salt or a vitamin as an active ingredient.
  • the mineral salt is preferably an inorganic mineral salt.
  • the inorganic mineral salt can be made from magnesium (II) salt,
  • Calcium (II) salt, potassium (I) salt, iron (II) salt, iron (III) salt and zinc (II) salt can be selected.
  • the vitamin can be selected from vitamins of the B complex and vitamin E.
  • the tampon Borago Officinalis can also contain oil.
  • the tampon contains a mineral salt or a vitamin as an active ingredient, the tampon surprisingly has an analgesic effect.
  • the tampon has a first active ingredient that is a drug and a second active ingredient that is a mineral salt or vitamin.
  • the tampon additionally has a third active substance, which is a homeopathic active substance.
  • the tampon additionally contains at least one magnesium (II) salt.
  • the magnesium (II) salt can be a salt from the following group of salts: magnesium (II) citrate, magnesium (II) oxide, magnesium (II) sulfate, magnesium (II) carbonate, magnesium (II) phosphate or
  • the tampon contains 0.3 to 1.0 g of drug, preferably 0.3 to 0.5 g of drug, in particular approximately 0.33 g of drug.
  • the tampon contains 0.05 to 0.5 g of mineral salt as an active ingredient. Such a tampon is optimal in terms of effectiveness in combination with an inexpensive use of the active ingredient.
  • the tampon contains 0.05 to 0.5 g of magnesium (II) salt, preferably 0.1 to 0.3 g of magnesium (II) salt and
  • magnesium (II) salt in particular about 0.2 g of magnesium (II) salt.
  • the magnesium (II) salt is preferably a mixture of 1 part by weight
  • Magnesium (ll) citrate and 1 part by weight of magnesium (ll) oxide are 1 part by weight of magnesium (ll) oxide.
  • the tampon can additionally contain further minerals and / or vitamins.
  • Magnesium (II), calcium (II), potassium (II), iron (II), iron (III), zinc (II) salts and vitamins of the B complex can be used as further minerals and / or vitamins and vitamin E, also in
  • the above-mentioned active ingredients, magnesium (II) salts or minerals and vitamins are preferably astringent, blood cleansing and hemostatic, antiseptic, antispasmodic, pain relieving, balancing and preventive in female diseases and have surprisingly been found to be suitable for treating general menstrual symptoms such as diarrhea, nausea , Headache, irregular menstrual cycles etc. Use can also be used for fibroids or endometriosis; Vaginal discharge; vaginal infections and premenstrual syndrome. Some substances are particularly effective in relieving menopausal symptoms or in the premenopause, while others are more cycle-regulating. It would therefore be practical to use different combinations of active ingredients for the different ones
  • the tampon contains from 0.3 to 1 g
  • the tampon contains 0.33 g lady's mantle.
  • the tampon contains from 1 to 10 mg of active ingredient, in particular a mixture of vitamin B complex with vitamin E.
  • the tampon contains 2 mg of vitamin B complex and 30 IU of vitamin E.
  • the tampon contains from 0.1 to 1 g of active ingredient, in particular a magnesium (II) salt. Ideally, the tampon contains 0.3 g of magnesium (II) salts.
  • the present invention relates to a tampon for preventing or alleviating dysmenorrhea in women.
  • the tampon can also be used as a medical tampon to relieve menstrual cramps in humans.
  • the active ingredient can be introduced as a tincture, in a capsule, as a liquid extract, oils, globules, as a paste in powdered or freeze-dried form in or on the tampon.
  • the active ingredients may have to be in a
  • Carrier e.g. hardened vegetable fats.
  • Active substance depot in the tampon core incorporation of the active substances into the tampon carrier material (usually viscose fibers) directly under or into the tampon cover (usually polyethylene, polypropylene or polyester.).
  • the tampon is therefore used like a commercial one
  • Chaste tree (agnus castus, Vitex agnus-castus)
  • Gynecological area of application cycle regulating, use
  • Origin The original distribution area of the monk's pepper extends from the Mediterranean to Southwest Asia to the Crimea.
  • Chaste tree fruits contain the following ingredients, among others: bicyclic diterpenes (Labdan and Clerodan type), such as rotundifuran; Iridoid glycosides (such as aucubin, agnuside); Castin (a bitter substance); lipophilic Flavonoids (such as casticin, penduletin); hydrophilic flavonoids (such as orientin, luteolin-7-glycoside, isovitexin); Triglycerides with alpha-linolenic, oleic and linoleic acid; essential oil with 4-terpineol, alpha-pinene and sesquiterpenes or beta-carophyll
  • Control-rate anomalies have been proven by clinical studies. The effectiveness has been made binding by at least one of the relevant evaluation commissions (Commission E / ESCOP / HMPC / WHO).
  • the daily dose is 30 to 40 mg of the corresponding drug
  • the dose with vaginal use can be lower.
  • Gynecological area of application for mild, temporary depressive disorders, such as those that occur during menopause
  • Hyperforin presumably an isoprenoid
  • 2-4% flavonoids hypooside, rutoside, 3,8'-biapigenin
  • 0.1% naphthodianthrones hypoicin and pseudohypericin
  • Emodinanthranol 10% catechin tannin; volatile oil.
  • Gynecological area of application Yarrow is used due to its astringent (wound-healing-promoting) and antibacterial effect, especially in inflammation and for hip baths for cramp-like and inflammatory abdominal pain in women.
  • Terpenes and flavonoids and their potency is comparable to that of papaverine from poppy species.
  • Homeopathy follows and uses the yarrow for cramp pain.
  • the yarrow is native to Europe, North Asia and North America and is valued worldwide as an ornamental and medicinal plant.
  • the related musk yarrow (A. moschata), native to the Alps, is also used in folk medicine.
  • the whole plant (Millefolii herba), the inflorescences (Millefolii flos) or the essential oil are used.
  • Menstrual problems inflammation of the uterus (colpitis), inflammation of the external genitals in women (vulvitis, see vaginal diseases): There are numerous indications from a long tradition of use in folk medicine and medical experience that suggest effectiveness.
  • Gynecological area of application traditionally for women like
  • Pedunculagin flavonoids e.g. a querceting lucuronide
  • Gynecological area of application menstrual problems, mild
  • Vaginal infections with bacteria, fungi or viruses Vaginal infections with bacteria, fungi or viruses.
  • the essential oil has an antispasmodic as well as soothing
  • Laboratory tests have an activity against bacteria, fungi and viruses.
  • Essential oil in roots: A complex blend of
  • Tannins rosemary acid (also known as rosemary acid).
  • the WHO emphasizes the antimicrobial, antispasmodic and calming effects of lemon balm.
  • the goose cinquefoil has a calming, anti-inflammatory and analgesic effect, which expands its possible uses even more.
  • Goose cinquefoil contains tannins, bitter substances, mucilages, flavonoids and choline as therapeutically effective ingredients. It mainly has an astringent effect and also has an analgesic and stuffing effect. Other ingredients are
  • Anthocyanidins hydroxycoumarins, phenol carboxylic acids, polyphenols and phytosterols.
  • Antibacterial and anti-inflammatory baths or douches help normalize the vaginal environment.
  • apigenin binds to the same receptor in the brain as many other synthetic sedatives (benzodiazepine receptor).
  • Chamomile extracts also contain the neurotransmitter GABA (y-aminobutyric acid), which plays a key role in stress and anxiety reactions and has a central depressant effect.
  • GABA y-aminobutyric acid
  • Essential oil (0.3 to 1.5%): Sesquiterpenes are an essential component of chamomile oil: Bisabolol, Bisabololoxid A, B, C, Bisabolonoxid, trans-ß-Farnesen.
  • Chamazulene is only created during steam distillation from the colorless precursor Matricin. The oil is therefore colored blue to blue-green.
  • Polyins Oils can contain up to 25% chemically reactive spiroethers (en-in-dicycloethers). These are labile substances and therefore not or only contained in traces in technically obtained oil.
  • Flavonoids Flavonoid and monoglycosides, acetylated flavone monoglycosides and their aglyca (0.5% apigenin-7-glucoside) are important for the chamomile effect.
  • Polysaccharides The mucilages (various sugar compounds; polysaccharides) are localized in the chamomile flowers.
  • Gynecological area of application menopause and
  • tetracyclic triterpene glycosides (actaein and cimicifugoside) and their aglyka (cimigenol, acetylacteol), isoflavones: formononetin, tannins: gallotannins, others: isoferulic acid, salicylic acid.
  • the daily dose should correspond to 40 mg drug. 1.9 Evening primrose oil (Oenothera biennis)
  • Gynecological area of application menopausal symptoms, mastodynia, premenstrual syndrome
  • a key ingredient in evening primrose is gamma-linolenic acid, a triple unsaturated fatty acid.
  • gamma-linolenic acid is broken down into 2 other acids (dihomo-gamma-linolenic acid and
  • Tissue hormones prostaglandins and leukotrienes
  • These tissue hormones affect the cholesterol level, the dilation of the blood vessels and are involved in inflammatory reactions.
  • the gamma-linolenic acid works
  • Palmitic acid 7% oleic acid.
  • Polyphenols catechin, epicatechin, gallic acid with cold pressing also became a pentacyclic triterpene ester
  • Premenstrual syndrome (recurring symptoms before the onset of a menstrual period): Several studies found evidence of the clinical effectiveness of evening primrose oil.
  • the nettle-strengthening plant is considered. As with menstruation, nettle can be used in PMS
  • leaves minerals (up to 5% silicic acid), amines (including histamine, acetylcholine, serotonin), flavonol glycosides, phenol carboxylic acids (chlorogenic acid, caffeic acid, caffeoylic malic acid), scopoletin, ß-sitosterol, tannins root: polysaccharides, lectin (UDA) Lignans, coumarins, sterols (including ß-sitosterol, 7a and 7ß-hydroxysitosterol and their glycosides)
  • the main active ingredients are furanochromones (g-pyrones) such as khellin, visnagin and khellol as well as pyranocoumarins such as visnadin and samidin. It also contains flavonoids, camphor oil and essential oil.
  • the juniper berries have a digestive effect through increased blood flow to the gastrointestinal mucosa. They also work
  • the berries are also suitable for regulating menstruation.
  • Juniper species mainly occur in the northern hemisphere. The juniper grows in the cooler and temperate regions of America, Asia and Europe.
  • Lignum juniperi The wood contains about 0.1% of an ethereal Oil, the main ingredient of which is thujopsen. 2.
  • the dried berries juniper berries or Cadigberries.
  • Scientific Juniperi fructus or Drupae juniperi, Galbuli juniperi, Pseudofructus iuniperi, Baccae juniperi, Fructus juniperi.
  • the berries contain sugar, tannins, flavonoids and between 0.5 and 2% juniper berry oil.
  • Juniperi aetheroleum Oleum Juniperi, Oleum juniperi baccarum. It contains various monoterpenes such as lime, myrcene, pinene and sabine. There are also a small proportion of sesquiterpenes. The main component is with about 25% pinene.
  • composition of the oil depends on the age of the shrub.
  • Gynecological area of application mild menorrhagia and metrorrhagia
  • Gynecological area of application general menstrual pain
  • the slightly analgesic and anti-inflammatory effect is based on the fact that certain ingredients of the devil's claw (iridoid glycosides or their breakdown products) inhibit an enzyme (cyclooxygenase) that plays an important role in inflammation.
  • the devil's claw is native to the savannahs of Thailand and South Africa.
  • Iridoid glycosides Harpagoside, Harpagid, 8-O-p-Coumaroylharpagid, Procumbid, 6’-0-p-Coumaroylprocumbid and Procumboside
  • Phenylethanoid glycosides verbascoid and isoacteoside, carbohydrates: stachyose, raffinose, sucrose, glucose, other ingredients: flavonoids, triterpenes, plant acids, etc.
  • the harpagoside content in the devil's claw root fluctuates between 1, 2% and 4%.
  • Gynecological area of application (fungal) infections, mild inflammation in the vagina.
  • the lauric acid contained in large quantities destroys the cell walls of the fungi, so that they ultimately die.
  • lauric acid has a strong antibacterial effect. This means that coconut oil both eliminates fungi and reduces inflammation.
  • Origin It is a palm of the warm, humid tropics and only fruits between the 26th degree south or north latitude.
  • coconut oil mainly consists of triglycerides, which contain saturated fatty acid residues, which differ from caprylic, lauric, capric, palmitic,
  • the triglycerides contain the monounsaturated oleic acid residue as well as traces of as the fatty acid residue
  • Gynecological area of application menstrual problems, mild
  • Vaginal infections with bacteria, fungi or viruses Vaginal infections with bacteria, fungi or viruses.
  • alcoholic extract and the oil are certified to be very effective, the tea is significantly less active.
  • the sage oil also reduced the number of dental plaque bacteria. Chewing fresh sage leaves is said to eliminate bad breath. In addition to the antibiotic effect, sage also supports wound healing due to its astringent properties.
  • Ursolic acid and derivatives The composition of the ingredients in the other two types of sage mentioned is as follows: Spanish sage (Salvia
  • lavandulifolia is thujone-free; contains 30-35% cineol and 30% camphor;
  • Gynecological application menstrual pain, mild vaginal and urinary tract infections Effect: Cranberry fruits combine several positive health effects
  • Pathogens are characterized by their stickiness. They adhere to all surfaces such as the oral mucosa, the bladder and intestinal wall. They often form films and deposits with other bacteria. The ingredients of the cranberry intervene here and promote the washing out of the germs with secretions such as saliva and urine.
  • organic acids (30%), including quinic acid, malic, citric and hippuric acids
  • polyphenols catechins, hydroxycinnamic and other phenolic acids, flavonoids (tannins, anthocyanins and proanthocyanidins)
  • Triterpenes vitamins: vitamin C, vitamins B1, B2, B3 and beta-carotene (vitamin A), minerals: especially potassium, calcium, magnesium and phosphate.
  • Gynecological area of application menstrual pain
  • fennel oil phenylpropane, predominantly trans-anethole (35-82% of the oil), cis-anethole, estragole (2-58% of the oil, depending on the variety), monoterpenes and sesquiterpenes: herb oil: a-Phellandren, a-pinene, a-terpinene, limonene, fruit oil: fenchone, a-pinene, camphene, myrcene, a- / ß-phellandrene, a-terpinene, limonene, terpinoiae, p-cymene;
  • the composition of the essential oil is different because it is dependent on several conditions (variety / cultivation / harvest / growing region).
  • Flavonoids fighter oil and querceting glycosides
  • Flavonol-3-O-glycosides and -3-O-glucuronides essential oils: coumarins (also as furano- and pyranocoumarins), aliphatic / aromatic carboxylic acids: hydroxybenzoic, benzoic and cinnamic acid derivatives
  • Ferula, fumaric, coffee and vanillic acid, sterols stigmasterol and stigmasterol palmitate, mineral salts, silicic acid and vitamins (vitamins A, B and C), storage substances: fatty oils and protein, sugar and oligosaccharides
  • Gynecological area of application menstruation-promoting, analgesic Origin: This type of plant originally comes from the Caucasus, but has been naturalized as an archeophyte in southern Europe and is now also found in the German-speaking world.
  • Verbena is native to the Mediterranean region, but it has long since reached Central Europe and grows there as a wild plant.
  • Gynecological field of application menstrual, blood cleansing Effect: The effectiveness for appetite stimulation, for digestive tract complaints such as gastritis or flatulence, for stimulating liver function and for convulsive disorders of the intestine and
  • wormwood contains 0.15 to 0.4% of a high concentration of bitter substances from the group of sesquiterpene lactones, including absinthin with 0.2 to 0.28% as the main component.
  • absinthin with 0.2 to 0.28% as the main component.
  • absinthin with 0.2 to 0.28% as the main component.
  • Essential oils make up 0.2 to 0.8% and contain (-) - thujone, (+) - isothujone, thujyl alcohol and its esters, chamazulen and other mono- and sesquiterpenes.
  • Various flavonoids have also been detected; Smaller amounts of polyacetylenes are suspected.
  • Angelica is therefore used for poor appetite, stomach cramps and flatulence.
  • Origin The Chinese angelica thrives wild or cultivated in forests and in the bushes at altitudes of 2500 to 3000 meters in the Chinese provinces of Sichuan, Gansu, Hubei, Shanxi and Yunnan.
  • Furanocoumarins xanthotoxin, imperator, angelicin, archangelin
  • Coumarins Umbelliferon, Osthol, Osthenol and others
  • essential oil roots and fruits: a-phellandrene, ß-phellandrene, a-pinene;
  • Osthol is the main ingredient in roots, imperator the most important ingredient in fruits.
  • lavender In addition to its calming and antispasmodic effect, lavender also has an antimicrobial and blood circulation-enhancing property sbiiThe essential oil - especially linalool - works against some bacteria and fungi.
  • Lavender oil also for relieving tension and relieving
  • lavender oil is evaporated for headaches, migraines and tension. It can also be massaged into the forehead and neck area. In fact, animal testing has shown a slight anesthetic effect.
  • Ingredients It is composed of linalyl acetate, linalool, camphor and cineol. Its ingredients are 40 to 50% esters, 25 to 35% monoterpenoie, monoterpenes, sesquiterpenes, ketones and oxides.
  • Hynecological area of application antibacterial, for weak and
  • Sesquiterpene lactones which are responsible for the bitter taste, and up to 0.2% complex essential oil.
  • Mugwort contains the following substance classes / substances: Essential oil: main components are camphor, thujone, 1, 8-cineol and linalool; Sesquiterpene lactones: vulgarine, pilostachyin;
  • Flavonoids quercetin, rutin; Hydroxycoumarins: umbelliferone, aesculetin; polyines; triterpenes; carotenoids
  • Viburnum opulus and Viburnum prunifol As an essential component of Viburnum opulus and Viburnum prunifol.
  • the bitter substance viburnin was previously stated, but has not been found by newer researchers.
  • the other more important ingredients, such as Valerian, formic and caprylic acid, tannin and resins are the same in both barks (Viburnum opulus and Viburnum prunifol.), And since the mode of action is similar, the prescription of Viburnum opulus is preferable for Europe ,
  • Origin The origin is on the American continent, but is uncertain.
  • Ingredients The dried bark. Content: a- and ß-amyrin, oleanol and
  • Ursolic acid cf. Formula, catechin, epicatechin, ethereal oil (approx. 0.3%), viburnin,
  • Gynecological area of application menorrhagia
  • Ginger grows in the tropics and subtropics. It is grown in countries such as Sri Lanka, India, Indonesia, Vietnam, China, Japan, Australia, France and Nigeria as well as in South America. The home of the ginger plant is not known for sure.
  • the essential components are an essential oil, resin acids and neutral resin as well as gingerol, a hot aromatic substance.
  • the gingerol gives the ginger the sharpness.
  • Ginger rootstock contains 1, 5-3% essential oil with substances such as geranial, neral and zingiberol.
  • the exact composition of the essential oil is influenced, among other things, by the origin and the type of ginger.
  • Other important active ingredients are non-volatile
  • Spicy substances such as gingeroie and shogaole.
  • the even sharper shogaols are formed when the drug is stored by splitting off water from the gingeroia.
  • Zingiberol is primarily responsible for the characteristic smell of ginger.
  • Gynecological area of application amenorrhea, dysmenorrhea,
  • Rosemary is native to the Mediterranean scrub.
  • the essential oil components 1, 8-cineol (16 to 55%) and camphor (5 to 15%) are mainly responsible for the effect of rosemary oil.
  • Gynecological area of application dysmenorrhea, menopausal symptoms
  • Minerals silicon (silica), potassium, magnesium, calcium, manganese; Saponins: equisetonin, flavonoids: luteolin, isoquercitrin, kaempferol, alkaloids: palustrin, tannins
  • Gynecological area of application menopausal symptoms
  • Hops are one of the hormonating herbs that can help balance hormones. Hops contain phytohormones, which can help with menopausal symptoms because they can compensate for the estrogen deficiency caused by the change. Hops are one of the most effective herbs for menopausal symptoms
  • homeopathic active ingredients are: Cimifuga, Pulsatilla, Colocynthis, Chamomilla, Agnus castus, Belladonna, magnesium phoshoricum, Calcium phosporicum. The list is not exhaustive.
  • minerals and vitamins are: magnesium, calcium, potassium, ferrum, zinc, vitamins of the B complex, vitamin E, also in combination with Borago Officinalis oil
  • Vitamins of the B complex especially pyridoxine (vitamin B6), also seem to have a positive effect on the symptoms. This is explained by the fact that vitamin B6 is an important cofactor in the
  • Soothing neurotransmitter synthesis Soothing neurotransmitter synthesis.
  • Vitamin E together with Borago Officinalis oil can also be used to treat premenstrual syndrome, because in combination with unsaturated fatty acids such as gamma-linolenic acid, it has symptoms in it
  • a first study group (study group I) was treated with a tampon containing 0.33 g of lady's mantle. The treatment was carried out with 6 tampons per 24 hours. The number of participants was 18. A survey found that there was no improvement in menstrual pain in one woman, partial improvement in 11 women, and complete improvement in 5 women.
  • a second study group (study group II) was treated with a tampon containing Chamomilla (D6), Cimicifuga (D6) and Agnus castus (D4).
  • the treatment was carried out with 6 tampons per 24 hours. The number of participants was 25.
  • a third study group (study group III) was treated with a tampon containing vitamin B complex (2 mg) and vitamin E (30 IU). The treatment was carried out with 6 tampons each 24 hours. The number of participants was 16.
  • the vitamin B complex comprised the following ingredients: 0.45 mg folic acid; 0.15 mg biotin; 0.01 mg cyanocobalamin (vitamin B12); 15 mg niacin equivalent; 15 mg riboflavin (vitamin B2); 10 mg pyridoxine hydrochloride (vitamin B6); 15 mg thiamine nitrate (vitamin B1).
  • the vitamin E had the following composition: 268 mg RRR-a-tocopherol equivalents (as all-rac-a-tocopherol acetate).
  • a fourth study group (study group IV) was treated with a tampon containing 3 mg of magnesium salts. The treatment was carried out with 6 tampons per 24 hours. The number of participants was 18.

Abstract

La présente invention concerne un tampon, comprenant au moins une substance active pour la prévention ou l'apaisement de la dysménorrhée.
PCT/DE2019/100742 2018-08-17 2019-08-19 Tampon WO2020035115A1 (fr)

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DE112019004134.7T DE112019004134A5 (de) 2018-08-17 2019-08-19 Tampon
EP19765645.7A EP3836948A1 (fr) 2018-08-17 2019-08-19 Tampon

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DE102018120142.7 2018-08-17
DE102018120142 2018-08-17

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WO2020035115A1 true WO2020035115A1 (fr) 2020-02-20

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022106032A1 (fr) * 2020-11-20 2022-05-27 Swiss-Canna Group Ag Tampon contenant une composition pharmaceutique

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US20020010447A1 (en) 2000-04-14 2002-01-24 Playtex Products, Inc. Fibrous absorbent articles having malodor counteratant ability and method of making same
US20030045829A1 (en) * 2001-08-29 2003-03-06 Kimberly-Clark Worldwide, Inc. Therapeutic agent delivery tampon
US20030120225A1 (en) * 2001-12-21 2003-06-26 Kimberly-Clark Worldwide, Inc. Therapeutic agent delivery labial pad
EP1455847A1 (fr) 2001-12-21 2004-09-15 Kimberly-Clark Worldwide, Inc. Produits d'hygiene feminine servant a apporter des substances therapeutiques
US20050276836A1 (en) * 1997-06-11 2005-12-15 Michelle Wilson Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents
WO2006017341A2 (fr) 2004-07-12 2006-02-16 Umd, Inc. Dispositifs vaginaux enduits destines a la mise en place d'agents therapeutiquement efficaces et/ou favorables a la sante
WO2007021098A1 (fr) 2005-08-13 2007-02-22 Purelyn Co., Ltd. Serviette hygiénique contenant une composition à base de plantes et procédé de fabrication de celle-ci
US20070141118A1 (en) * 2005-12-15 2007-06-21 Damico Joyce A Layered dosage form for a medicated tampon assembly

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050276836A1 (en) * 1997-06-11 2005-12-15 Michelle Wilson Coated vaginal devices for vaginal delivery of therapeutically effective and/or health-promoting agents
US20020010447A1 (en) 2000-04-14 2002-01-24 Playtex Products, Inc. Fibrous absorbent articles having malodor counteratant ability and method of making same
US20030045829A1 (en) * 2001-08-29 2003-03-06 Kimberly-Clark Worldwide, Inc. Therapeutic agent delivery tampon
US20030120225A1 (en) * 2001-12-21 2003-06-26 Kimberly-Clark Worldwide, Inc. Therapeutic agent delivery labial pad
EP1455847A1 (fr) 2001-12-21 2004-09-15 Kimberly-Clark Worldwide, Inc. Produits d'hygiene feminine servant a apporter des substances therapeutiques
WO2006017341A2 (fr) 2004-07-12 2006-02-16 Umd, Inc. Dispositifs vaginaux enduits destines a la mise en place d'agents therapeutiquement efficaces et/ou favorables a la sante
WO2007021098A1 (fr) 2005-08-13 2007-02-22 Purelyn Co., Ltd. Serviette hygiénique contenant une composition à base de plantes et procédé de fabrication de celle-ci
US20070141118A1 (en) * 2005-12-15 2007-06-21 Damico Joyce A Layered dosage form for a medicated tampon assembly

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022106032A1 (fr) * 2020-11-20 2022-05-27 Swiss-Canna Group Ag Tampon contenant une composition pharmaceutique

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DE112019004134A5 (de) 2021-05-06

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