WO2020032607A1 - Membrane de protection pour régénérer un tissu parodontal - Google Patents

Membrane de protection pour régénérer un tissu parodontal Download PDF

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Publication number
WO2020032607A1
WO2020032607A1 PCT/KR2019/009943 KR2019009943W WO2020032607A1 WO 2020032607 A1 WO2020032607 A1 WO 2020032607A1 KR 2019009943 W KR2019009943 W KR 2019009943W WO 2020032607 A1 WO2020032607 A1 WO 2020032607A1
Authority
WO
WIPO (PCT)
Prior art keywords
core plate
periodontal tissue
shielding membrane
membrane
tissue regeneration
Prior art date
Application number
PCT/KR2019/009943
Other languages
English (en)
Korean (ko)
Inventor
김수홍
Original Assignee
(주) 코웰메디
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by (주) 코웰메디 filed Critical (주) 코웰메디
Publication of WO2020032607A1 publication Critical patent/WO2020032607A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0003—Not used, see subgroups
    • A61C8/0004—Consolidating natural teeth
    • A61C8/0006—Periodontal tissue or bone regeneration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2/2846—Support means for bone substitute or for bone graft implants, e.g. membranes or plates for covering bone defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses

Definitions

  • the present disclosure relates to a periodontal tissue regeneration shield that wraps and supports an alveolar bone defect filled with bone graft material during an osteoinductive regeneration procedure.
  • teeth are body tissues responsible for the chewing function that helps to digest food by crushing or grinding food.
  • teeth are lost due to tooth extraction, for example, tooth decay, they cause chewing problems, so they can't chew food properly and can't digest well. do.
  • teeth have long been recognized as an important part of the body and play an important role in leading a healthy life.
  • humans have a total of 32 teeth, including 16 teeth in the maxilla and 16 teeth in the mandible, and after the childish teeth are replaced with permanent teeth once in childhood, they use oral activity for a lifetime. To perform.
  • a dental tooth repairs a tooth or a surrounding tissue that has been lost through prosthetic treatment.
  • Dental implants are largely composed of a fixture fixed to the alveolar bone, an abutment coupled to the fixture, and a crown integrally coupled to the abutment.
  • Fixtures correspond to artificial roots embedded in the alveolar bone
  • abutments serve to connect the fixtures and crowns
  • crowns correspond to artificial teeth that reproduce the same shape and function as natural teeth.
  • the dental implant procedure is the first step to form a groove corresponding to the fixture in the alveolar bone through drilling and tapping to embed the fixture in the alveolar bone, and to attach the abutment to the implanted fixture to install the artificial tooth Consists of steps.
  • the dental implant can be firmly fixed only if there is a sufficient amount of alveolar bone intact to place the dental implant in the site where the tooth is lost.
  • the remaining alveolar bone alone cannot sufficiently support the fixture.
  • the bone graft material can be performed as a new alveolar bone after filling a bone graft material such as autologous bone or artificial bone in the defective part, which is called bone guide regeneration (GBR). It is called).
  • GLR bone guide regeneration
  • bone graft artificial bone or autologous bone
  • periodontal tissue regeneration shielding to maintain the required form.
  • the periodontal tissue regeneration shield is a membrane that provides a space for bone formation by preventing the penetration of fibroblasts originating from soft tissues such as gums into the bone graft during the period when the alveolar bone is restored to normal levels. Fibroblasts originating from soft tissues, such as gums, generally occlude alveolar bone graft sites and thus prevent alveolar bone production. Therefore, the alveolar bone graft site should be separated from soft tissues such as gums through a periodontal tissue regeneration mask.
  • Korean Patent Publication No. 10-2013-0083204 (published on July 22, 2013) is disposed on the defect of the alveolar bone to form a space for regeneration of the alveolar bone or to surround the bone graft material
  • the dental membrane which is fixed by the implant insert is inserted into the alveolar bone is fixed to the membrane, the upper portion surrounding the upper surface of the alveolar bone defects filled with bone graft material, and the bone graft material is bent downward from the upper side Comprising a side bent portion surrounding the side of the filled alveolar bone defect portion, wherein the upper portion is disposed in a portion corresponding to the portion is inserted into the implant insert and the central portion is formed with a central hole to which the implant insert is coupled And arranged to surround at least a portion of the central portion and into the central portion.
  • the membranes for dentistry characterized in that it comprises a wave pillar forming portion for guiding so as to form a convexly pro
  • the periodontal tissue regeneration membrane is an absorbent periodontal tissue regeneration membrane, characterized in that the biodegradable polymer material.
  • the Republic of Korea Patent Registration No. 10-1731057 (2017.04.27.) Has at least one contact portion and is configured to have a thin plate-shaped body formed with a plurality of extensions around the contact portion, the titanium core capable of deformation of the shape by an external force And a first PTFE (polytetrafluoroethylene) membrane provided on one side of the titanium core, and a second PTFE membrane provided on the other side of the titanium core.
  • PTFE polytetrafluoroethylene
  • the above-described periodontal tissue regeneration shielding membrane has a structure in which a single fastening hole for fastening and fastening is fixed to the upper part of the fixture, and thus it is difficult to adjust the fastening site according to the surgical site. There is a problem that must be separately cut or additionally formed fastening hole.
  • the purpose of the present invention is to provide a periodontal tissue regeneration shield so that the fastening position of the implant insert can be quickly and easily adjusted according to the surgical site.
  • a core plate made of a metal plate capable of shape deformation by external force and a plurality of fastening holes penetrated so as to be fastened and fixed on an implant insert, and a first shield laminated on one side of the core plate.
  • a membrane for regenerating a periodontal tissue including a membrane and a second shielding membrane laminated on the other side of the core plate and integrally bonded to the first shielding membrane are provided.
  • the fastening holes may be spaced apart from each other, or may be continuously formed in communication with a plurality of the plurality along the longitudinal center line of the core plate in the longitudinal direction or the width direction.
  • the fastening position of the implant insert can be quickly and easily adjusted according to the surgical site, thereby increasing the convenience of the procedure.
  • the membrane for regenerating periodontal tissue according to the disclosure, it is possible to continuously form a plurality of fastening holes connected to each other in communication with the core plate, so that the fastening position for the implant insert can be finely adjusted according to the surgical site more precise and effective bone guidance There is an advantage that can be a regenerative procedure.
  • Figure 1 is a cross-sectional view of the use state of the periodontal tissue regeneration shield in accordance with an embodiment of the disclosed contents.
  • Figure 2 is a perspective view of the periodontal tissue regeneration shielding film according to an embodiment of the disclosure.
  • Figure 3 is an exploded perspective view of the periodontal tissue regeneration shielding membrane according to an embodiment of the disclosure.
  • Figure 4 is a planar structure diagram of various embodiments of the core plate in the membrane for regenerating periodontal tissue according to an embodiment of the present disclosure.
  • FIG. 5 is a planar structural diagram of various embodiments of a periodontal tissue regeneration shielding membrane according to an embodiment of the disclosed contents
  • Figure 6 is a planar view illustrating the fastening position adjustment of the periodontal tissue regeneration shielding membrane according to an embodiment of the present disclosure.
  • Figure 7 is a perspective view after the molding of the periodontal tissue regeneration shielding film according to an embodiment of the present disclosure.
  • FIG. 1 is a cross-sectional view illustrating the use state of the periodontal tissue regeneration shield according to an embodiment of the present disclosure.
  • the periodontal tissue regeneration shield 1 is a bone fastened to the upper end of the implant (3) buried in the bone in the bone during regeneration procedure as shown in Figure 1 Graft fills the alveolar bone defect and serves to support it.
  • the periodontal tissue regeneration shield (1) at the same time prevents the infiltration of fibroblasts derived from soft tissues such as gums into the bone graft material during the period of recovery of the scarce alveolar bone to the normal level Support the bone graft to maintain the required shape.
  • FIG. 2 is a perspective view of a periodontal tissue regeneration shield according to an embodiment of the disclosure
  • Figure 3 is an exploded perspective view of the periodontal tissue regeneration shield according to an embodiment of the disclosure.
  • the shielding membrane 1 for periodontal tissue regeneration is made of a metal plate capable of deforming shape by external force and is positioned on an implant insert 3.
  • Core plate 10 through which a plurality of fastening holes 11 are formed to be adjusted and fastened, the first shielding membrane 20 stacked on one side of the core plate 10, and the other of the core plate 10.
  • the second shield membrane 30 is laminated on the side and integrally bonded to the first shield membrane 20.
  • the core plate 10 may be interposed between the first shielding membrane 20 and the second shielding membrane 30 to maintain the periodontal tissue regeneration shielding membrane 1 according to an embodiment of the disclosure.
  • a core material to be made, for example, using a metal material such as titanium or titanium alloy can be manufactured in the form of a thin film, for example 0.01 to 0.1mm thick.
  • Titanium or titanium alloys are light, nonmagnetic, excellent in mechanical properties such as corrosion resistance, strength, and toughness, and are also very suitable for use in dental implants because of their excellent biocompatibility.
  • the core plate 10 made of titanium or titanium alloy is cut and processed by laser or the like.
  • the fastening holes 11 for fastening and fastening on the implant insert 3 are formed in a plurality, so that the fastening position can be easily adjusted according to the surgical site or the alveolar bone defect.
  • FIG. 4 is a planar structural diagram of various embodiments of a core plate in a membrane for regenerating periodontal tissue according to an embodiment of the present disclosure.
  • the plurality of fastening holes 11 formed on the core plate 10 may be spaced apart at regular intervals according to a plurality of rows and columns, as shown in FIGS. As shown in FIG. 4, it is preferable that a plurality of the core plates 10 are continuously connected to each other by being connected to each other along the center line in the longitudinal direction or the width direction of the core plate 10.
  • the first shielding membrane 20 and the second shielding membrane 30 are preferably made of a synthetic resin material, in particular, polytetrafluoroethylene (PTFE) sheet.
  • PTFE polytetrafluoroethylene
  • Polytetrafluoroethylene is a fluorine-based polymer known under trade names such as Dupont and Fluon (ICI).
  • Polytetrafluoroethylene (PTFE) forms a very stable compound due to the strong chemical bonding of fluorine and carbon, resulting in almost perfect chemical inertness and heat resistance (stable at 250 ° C), non-tackiness, good insulation and low coefficient of friction. And is particularly suitable as a material for dental shielding materials due to its non-adhesive nature.
  • first shielding membrane 20 and the second shielding membrane 30 non-stretched general polytetrafluoroethylene (PTFE) may be used, or stretched polytetrafluoroethylene (e-PTFE) may be used. have.
  • the thickness of the first shielding membrane 20 and the second shielding membrane 30 preferably has a thickness of 0.01 to 0.1mm, for example.
  • first shielding membrane 20 and the second shielding membrane 30 are integrally joined by heat fusion or ultrasonic fusion in a state in which the core plate 10 is surrounded on both sides.
  • the first shielding membrane 20 and the second shielding membrane 30 are integrally fused to each other in the outer circumference of the core plate 10 and in the fastening hole 11.
  • both surfaces of the core plate 10 in contact with the first shielding membrane 20 and the second shielding membrane 30 are fine patterned by, for example, a laser or the like to increase the bonding area.
  • FIG. 5 is a planar structural diagram of various embodiments of a periodontal tissue regeneration shield according to one embodiment of the disclosed contents.
  • a plurality of fastening holes 11 are integrally formed between the first shielding membrane 20 and the second shielding membrane 30 by the core plate 10. It is formed into an intervening structure.
  • the plurality of fastening holes 11 formed in the core plate 10 are continuously formed so as to be connected to each other in communication with each other along the center line in the longitudinal direction or the width direction of the core plate 10, as shown in FIG. 6.
  • the core plate 10 is formed in a crisscross shape along the longitudinal center line and the longitudinal center line in the width direction.
  • the core plate 10 has a crisscross shape in the center so that the cut surface of the core plate 10 is not exposed. It is preferable to have a structure in which concentric arc-shaped lines are connected to each other by radial connecting lines on both sides or at least one side along a longitudinal direction with respect to the fastening hole 11 formed as a.
  • three concentric arc-shaped lines are preferably spaced apart from each other, and the radial connecting line is formed of only one connecting across the center of the concentric arc-shaped line, or the center of the concentric arc-shaped line. It can be formed in three connecting across both ends.
  • the core plate 10 has a concentric arc-shaped line formed on both sides or at least one side of the fastening hole 11 formed in a crisscross shape at the center thereof by a radial connecting line.
  • PTFE polytetrafluoroethylene
  • the periodontal tissue regeneration shielding membrane 1 according to an embodiment of the present disclosure after regeneration of the periodontal tissue can be easily removed without large resistance.
  • FIG. 6 is a planar structural diagram illustrating the fastening position adjustment of the shielding membrane for periodontal tissue regeneration according to one embodiment of the disclosed contents.
  • a plurality of fastening holes 11 are formed in the core plate 10 and correspond to the fastening holes 11 of the core plate 10.
  • the first through hole 21 and the second through hole 31 are formed in the first shielding membrane 20 and the second shielding membrane 30, respectively, the implant insert 3 according to the surgical site or the alveolar bone defect site, etc.
  • the fastening position with respect to can be adjusted quickly and easily.
  • a plurality of fastening holes (11) in the core plate 10 can be continuously connected to each other in communication, the surgical site or alveolar bone defects
  • the fastening position for the implant insert (3) according to the site can be fine-adjusted to enable more sophisticated yet effective bone oil regeneration procedure.
  • FIG. 7 is a perspective view of the periodontal tissue regeneration shielding film after shaping in accordance with one embodiment of the disclosed contents.
  • a fastening position for the implant insert 3 is selected according to a surgical site or an alveolar bone defect site among a plurality of fastening holes 11, as shown in FIG. 7, for example, a fastening hole at a corresponding position through a bending machine or the like.
  • One or both sides of the periodontal tissue regeneration shielding membrane 1 according to an embodiment of the present disclosure with reference to (11) may be preformed to be curved downward in the longitudinal direction.
  • an implant insert 3 consisting of the fixture 3a and the abutment 3b is inserted into the alveolar bone 5 and bone defects are present. Fill the bone graft material (7) to the site.
  • the periodontal tissue regeneration shielding film (1) formed in a three-dimensional shape in advance based on the fastening hole (11) selected according to the treatment site or the alveolar bone defect site or the like is bonded onto the implant insert (3).
  • the fastening hole 11 is inserted onto the implant insert 3 and fastened with the fastening fastener 4 for fastening the barrier membrane, so that the periodontal tissue regeneration shield 1 is fixed to the upper side of the bone graft material 7. .
  • the gingiva 9 is then sutured after covering the gingiva 9 over the periodontal tissue regeneration shield 1 according to one embodiment of the disclosed subject matter.
  • the sutured gingiva 9 is opened and the periodontal tissue regeneration shielding membrane according to an embodiment of the disclosure (1) is removed from the bone defect and subsequent implantation is performed continuously.
  • the posted content is applicable to the field of osteoinductive regeneration of dental implants.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Dentistry (AREA)
  • Dental Prosthetics (AREA)

Abstract

L'invention concerne une membrane de protection pour la régénération d'un tissu parodontal, une position à laquelle un matériau inséré pour un implant doit être couplé pouvant être ajustée rapidement et facilement selon une région de procédure. Selon un mode de réalisation, l'invention concerne une membrane de protection pour régénérer un tissu parodontal, la membrane de protection comprenant : une plaque centrale constituée d'un matériau de plaque métallique dont la forme peut être modifiée par une force externe, et ayant de multiples trous de couplage formés à travers celui-ci de telle sorte que la plaque centrale est ajustée en position sur et couplée et fixée à un matériau inséré pour un implant ; une première membrane de protection stratifiée sur une surface latérale de la plaque centrale ; et une seconde membrane de protection stratifiée sur l'autre surface latérale de la plaque centrale, et liée d'un seul tenant à la première membrane de protection. Les trous de couplage sont soit formés à travers la plaque centrale tout en étant espacés les uns des autres, soit formés en continu de façon à être en contact et à communiquer les uns avec les autres long de la ligne centrale longitudinale ou dans le sens de la largeur de la plaque centrale.
PCT/KR2019/009943 2018-08-08 2019-08-08 Membrane de protection pour régénérer un tissu parodontal WO2020032607A1 (fr)

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KR10-2018-0092571 2018-08-08
KR1020180092571A KR101998847B1 (ko) 2018-08-08 2018-08-08 치주조직 재생용 차폐막

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KR101998847B1 (ko) * 2018-08-08 2019-07-11 (주) 코웰메디 치주조직 재생용 차폐막
KR20220138151A (ko) 2021-04-05 2022-10-12 정록영 골 결손 부위의 치주조직 재생을 위한 거미섬유를 이용한 흡수성 차폐막

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KR20150098889A (ko) * 2014-02-21 2015-08-31 주식회사 네오바이오텍 치과용 혼합 차폐막
WO2016051165A1 (fr) * 2014-09-30 2016-04-07 Neoss Limited Membrane chirurgicale
KR101731055B1 (ko) * 2016-08-02 2017-04-27 권태수 치과 시술용 차폐막
KR20180013352A (ko) * 2016-07-29 2018-02-07 주식회사 메가젠임플란트 치과용 차폐막 및 그 제조방법
KR101998847B1 (ko) * 2018-08-08 2019-07-11 (주) 코웰메디 치주조직 재생용 차폐막

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KR101298249B1 (ko) 2012-01-12 2013-08-22 오스템임플란트 주식회사 치과용 멤브레인
KR200471683Y1 (ko) * 2012-05-09 2014-03-11 주식회사 메가젠임플란트 치과용 차폐막
KR101649120B1 (ko) 2015-01-23 2016-08-18 오스템임플란트 주식회사 흡수성 치주조직 재생막 및 이를 보관하는 앰플
KR101731057B1 (ko) 2016-08-02 2017-04-27 권태수 치과 시술용 차폐막
KR102182882B1 (ko) * 2016-12-30 2020-11-25 주식회사 네오바이오텍 돼지 진피-유래 치과용 차폐막 및 이의 제조방법

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KR20150098889A (ko) * 2014-02-21 2015-08-31 주식회사 네오바이오텍 치과용 혼합 차폐막
WO2016051165A1 (fr) * 2014-09-30 2016-04-07 Neoss Limited Membrane chirurgicale
KR20180013352A (ko) * 2016-07-29 2018-02-07 주식회사 메가젠임플란트 치과용 차폐막 및 그 제조방법
KR101731055B1 (ko) * 2016-08-02 2017-04-27 권태수 치과 시술용 차폐막
KR101998847B1 (ko) * 2018-08-08 2019-07-11 (주) 코웰메디 치주조직 재생용 차폐막

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