WO2019225755A1 - Deodorant and deactivating agent - Google Patents

Deodorant and deactivating agent Download PDF

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Publication number
WO2019225755A1
WO2019225755A1 PCT/JP2019/020760 JP2019020760W WO2019225755A1 WO 2019225755 A1 WO2019225755 A1 WO 2019225755A1 JP 2019020760 W JP2019020760 W JP 2019020760W WO 2019225755 A1 WO2019225755 A1 WO 2019225755A1
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Prior art keywords
extract
component
deodorant
tension
odor
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PCT/JP2019/020760
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French (fr)
Japanese (ja)
Inventor
落合 正敏
雅子 勝山
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株式会社 資生堂
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Priority to JP2020520404A priority Critical patent/JP7485597B2/en
Priority to CN201980035247.8A priority patent/CN112203631B/en
Publication of WO2019225755A1 publication Critical patent/WO2019225755A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27Zinc; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00Disinfection, sterilisation or deodorisation of air
    • A61L9/01Deodorant compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00Anti-perspirants or body deodorants

Definitions

  • the present disclosure relates to a deodorant that eliminates or reduces discomfort caused by body odor.
  • the present disclosure relates to an inactivating agent that inactivates a physiological / psychological activity (modulation) action by a secretory component from a human body.
  • aging odor is known as a body odor peculiar to middle-aged and elderly people (see, for example, Patent Document 1).
  • the aging odor suppressing fragrance composition described in Patent Document 1 has a component excellent in the masking effect on the aging odor and / or a component excellent in the harmony effect on the aging odor. It is blended.
  • Patent Document 2 discloses at least one selected from the group consisting of butyl 2-methylbutanoate, ⁇ -terpinene, dipentene, cis-4-heptenal, 1,4-cineole, trimethylhexylaldehyde, and (+)-limonene oxide.
  • An inhibitor of the odor of a polysulfide compound is disclosed which contains as an active ingredient.
  • the present inventors have noticed that there is a peculiar smell around a person who is in a tension state (stress state) in which the heart rate increases due to mental stress. Therefore, the present inventors have studied the cause of the odor.
  • the odor is a body odor caused by a substance secreted / released from a person in a tension state or a mental stress state (hereinafter referred to as “tension” in this disclosure). Odor "or” stress odor ").
  • This tension odor is a sulfur-based odor that many people will feel uncomfortable.
  • interest in body odor has increased, and it is expected that demand for deodorants that can eliminate or reduce discomfort caused by tension odor will increase.
  • the odor suppressor described in Patent Document 2 refers only to bad odors other than the human body such as drain outlets and garbage, and has not been studied for bad odors emitted from the human body, and the odor described in Patent Document 2 It is unclear whether the suppressor can suppress the tension odor.
  • a component secreted and released from a person who is in a tension state or mental stress state has at least one of a physiologically active action and a psychologically active action. thinking. Therefore, for an inactive agent that inactivates a physiologically active action and / or a psychologically active action by a component secreted from a person in tension or mental stress (hereinafter referred to as “tension odor component”). Demand is expected to increase.
  • a tension odor deodorant containing at least one of the first deodorant component and the second deodorant component is provided.
  • the first deodorizing component includes at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Camsnar extract, Lumpuyan extract, and combinations thereof.
  • the second deodorant component is composed of laponite, silver supported zeolite, zinc oxide, neem leaf extract, iris root extract, perilla leaf extract, hydroxypropyl- ⁇ -cyclodextrin, sanna extract, tocopherol, and combinations thereof. Including at least one selected from the group.
  • a tension odor deodorant containing at least one of the first deodorant component and the second deodorant component is provided.
  • the first deodorizing component includes at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Camsnar extract, Lumpuyan extract, and combinations thereof.
  • the second deodorant component is zinc oxide, laponite, silver-supported zeolite, dibutylhydroxytoluene, sugarcane extract, loquat leaf extract, iris root extract, perilla leaf extract, hydroxypropyl- ⁇ -cyclodextrin, sanna extract, green tea extract, And at least one selected from the third group consisting of combinations thereof.
  • an inactivating agent including at least one of the first deodorizing component and the second deodorizing component.
  • the first inactivating component includes at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Camsnar extract, Lumpuyan extract, and combinations thereof.
  • the second inactivating component is composed of laponite, silver-supported zeolite, zinc oxide, neem leaf extract, iris root extract, perilla leaf extract, hydroxypropyl- ⁇ -cyclodextrin, sanna extract, tocopherol, and combinations thereof.
  • At least one selected from the group of: Inactivators inactivate the psychological or psychoactive activity of secretory components.
  • an inactivating agent including at least one of the first deodorant component and the second deodorant component.
  • the first deactivator component includes at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, camsnar extract, lumpyan extract, and combinations thereof.
  • the second deactivator component is zinc oxide, laponite, silver supported zeolite, dibutylhydroxytoluene, sugarcane extract, loquat leaf extract, iris root extract, perilla leaf extract, hydroxypropyl- ⁇ -cyclodextrin, sanna extract, green tea And at least one selected from a third group consisting of extracts and combinations thereof.
  • Inactivators inactivate the psychological or psychoactive activity of secretory components.
  • the inactivating agent of the present disclosure it is possible to inactivate or suppress the psychological or physiological activity action by the tension odor component.
  • the tension odor is an odor emitted from the body due to a tension state and / or mental stress.
  • the causative substance of the tension odor includes at least one of allyl mercaptan and dimethyl trisulfide.
  • the causative substance further contains at least one compound selected from the group consisting of methyl mercaptan, dimethyl sulfide, dimethyl disulfide, and combinations thereof.
  • the causative substance further includes 1-octen-3-one.
  • the secretory component is a component secreted from the body due to tension and / or mental stress.
  • the secretory component contains at least one of allyl mercaptan and dimethyl trisulfide.
  • the secretory component further contains at least one compound selected from the group consisting of methyl mercaptan, dimethyl sulfide, dimethyl disulfide, and combinations thereof.
  • the secretory component further contains 1-octen-3-one.
  • the deodorant of the present disclosure is a deodorant that can be suitably applied to body odor (tension odor) emitted when a person is in a tension state and / or a mental stress state.
  • the deodorant in the present disclosure refers to a substance that removes or reduces malodor by a chemical action and / or a physical action on a causative substance of a smell to be deodorized (hereinafter referred to as “bad odor”).
  • bad odor a substance that removes or reduces malodor by a chemical action and / or a physical action on a causative substance of a smell to be deodorized
  • the deodorizer of the present disclosure includes at least one of a first deodorant component and a second deodorant component.
  • the first deodorant component can include at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide (powder), Kamsnar extract, Lumpuyan extract, and combinations thereof.
  • the first deodorant component is considered to be useful for deodorizing malodor caused by allyl mercaptan among causative substances of tension odor.
  • the silver-supported zeolite includes, for example, one in which at least a part of ion-exchangeable ions in the zeolite is replaced with silver ions.
  • the silver ion content in the silver-supported zeolite can be, for example, 0.1% by mass to 15% by mass.
  • the second deodorant component is laponite, silver supported zeolite, zinc oxide, neem leaf extract, iris leaf extract, perilla leaf extract, hydroxypropyl- ⁇ -cyclodextrin, sanna extract, tocopherol, dibutylhydroxytoluene, sugarcane extract, loquat leaf It may comprise at least one selected from the second group consisting of extracts, green tea extracts, and combinations thereof.
  • the second deodorizing component is considered to be useful for deodorizing malodor caused by dimethyl trisulfide, among substances causing tension odor.
  • the second deodorant component is (A) zinc oxide and (B) laponite, silver-supported zeolite, dibutylhydroxytoluene, sugarcane extract, loquat leaf extract, iris root extract, perilla leaf extract, hydroxypropyl- ⁇ -cyclodextrin , Sanna extract, green tea extract, and at least one selected from the third group consisting of combinations thereof. According to this combination, the deodorizing effect of the tension odor can be further enhanced.
  • Zinc oxide can be fine powder.
  • the average particle diameter of zinc oxide can be, for example, 5 ⁇ m or less, 3 ⁇ m or less, 2 ⁇ m or less, 1 ⁇ m or less, or 0.5 ⁇ m or less.
  • the main components of the causative substance of the tension odor are allyl mercaptan and dimethyl trisulfide, as will be described later. Both substances have a particularly large impact on the sense of smell. Therefore, if the odors of allyl mercaptan and dimethyl trisulfide are eliminated, the tension odor can be effectively eliminated.
  • the deodorant of the present disclosure can be sprayed in the air in advance and / or after the event to a place where a tension odor is generated and / or a place where the tension odor may be generated.
  • the deodorant can be attached or spread on cloth products such as clothes, curtains and carpets in advance and / or after the fact. If the deodorant does not adversely affect the skin, the deodorant can be applied to the skin in advance and / or after the fact.
  • a deodorant can be applied to a place where a tension odor component is considered to be secreted, for example, palm, armpit, foot, back, head, face, oral cavity, and the like.
  • the deodorant of the present disclosure can be used in combination with other deodorants, those that remove or mitigate bad odors by chemical, biological, physical action and the like.
  • the deodorant of the present disclosure can further contain a deodorizing component, a deodorizing component, another deodorizing component, and the like as long as the effect of the deodorant of the present disclosure is not impaired.
  • the deodorant according to the present disclosure can eliminate or suppress the discomfort that occurs when smelling a tense odor. Moreover, a person who is or has been in a tension state or a mental stress state, or a person who is likely to become a tension state or a mental stress state in the future generates a tension odor by using the deodorant of the present disclosure. It is possible to eliminate or reduce the anxiety that it may have occurred and the anxiety that it may generate a tense odor in advance and / or after the fact.
  • the tension odor component has at least one of a psychological activity and a physiological activity on humans. For example, when a person senses a tense odor, or when an olfactory receptor responds to a tense odor component, it becomes clear that the person is mentally fatigued, confused, or awakened. It's getting on.
  • the tension odor component may have a psychoactive activity and / or psychological activity other than these.
  • the inactivating agent of the present disclosure has an effect of inactivating such a mental activity and / or psychological activity of the tension odor component.
  • the person when a person senses the scent of the inactivation agent of the present disclosure, mixes and smells the scent of the inactivation agent and a tension odor, or when the olfactory receptor responds to the inactivation agent, etc.
  • the person can eliminate or suppress the mental modulation and / or psychological modulation as described above.
  • Negative emotions include, for example, “anger / hostility”, “confused / embarrassed”, “depressed / depressed”, “fatigue / impotence”, and “tension / impotence” based on the POMS (Profile of Mood States) test. Anxiety ”is mentioned. It has been found that the tension odor particularly increases “confused / embarrassed”, “fatigue / apathy” and “tension / anxiety”. Positive emotions include, for example, “liveliness / energy” and “friendship”.
  • the deactivating agent of the present disclosure includes at least one of a first deactivating component and a second deactivating component.
  • the first deactivating component can include at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Kamsnar extract, Lumpuyan extract, and combinations thereof.
  • the first inactivating component is considered to be useful for inactivating malodor caused by allyl mercaptan among causative substances of tension odor.
  • the second inactivating component is laponite, silver supported zeolite, zinc oxide, neem leaf extract, iris root extract, perilla leaf extract, hydroxypropyl- ⁇ -cyclodextrin, sanna extract, tocopherol, dibutylhydroxytoluene, sugarcane extract, loquat At least one selected from the second group consisting of leaf extract, green tea extract, and combinations thereof may be included.
  • the second inactivating component is considered to be useful for inactivating malodor caused by dimethyl trisulfide, among the causative substances of tension odor.
  • the second inactivating component is (A) zinc oxide and (B) laponite, silver-supported zeolite, dibutylhydroxytoluene, sugarcane extract, loquat leaf extract, iris root extract, perilla leaf extract, hydroxypropyl- ⁇ -cyclo
  • Zinc oxide can be fine powder.
  • the average particle diameter of zinc oxide can be, for example, 5 ⁇ m or less, 3 ⁇ m or less, 2 ⁇ m or less, 1 ⁇ m or less, or 0.5 ⁇ m or less.
  • Psychologically active and physiologically active effects due to the tension odor component, and inactivation of the tension odor component due to the inactive agent are, for example, a method using a psychological questionnaire such as POMS (registered trademark) (Profile of Mood States). ), GACL (General Activity Checklist) or the like.
  • POMS registered trademark
  • GACL General Activity Checklist
  • the main components of the causative substance of the tension odor are allyl mercaptan and dimethyl trisulfide, as will be described later. Both substances have a particularly large impact on the sense of smell. Therefore, if the odors of allyl mercaptan and dimethyl trisulfide are eliminated, the psychological and / or physiologically active action due to the tension odor can be effectively inactivated.
  • the inactivating agent of the present disclosure can be sprayed in the air in advance and / or after the event in a place where a tension odor component is generated and / or a place where it may be generated.
  • the deactivator can also be applied or spread on fabric products such as clothes, curtains and carpets in advance and / or after the fact. If the deactivator does not adversely affect the skin, the deactivator can be applied to the skin in advance and / or after the fact.
  • the deactivator can be applied to a part that is considered to secrete a tense odor component, such as the palm, armpit, foot, back, head, face, oral cavity, and the like.
  • the inactivating agent of the present disclosure can be used in combination with other psychological and physiological action inactivating agents and the like.
  • the inactivation agent of the present disclosure may further contain another inactivation agent as long as the effect of the inactivation agent of the present disclosure is not inhibited.
  • Other deactivators include, for example, those that remove or mitigate malodors by chemical, biological, physical action, etc. against malodors (eg, tension odors) (eg, deodorant components, deodorant components, deodorant components) Etc.).
  • the inactivating agent of the present disclosure can inactivate the mental activity and / or psychological activity of the tension odor component. Thereby, psychological modulation, physiological modulation, and the like caused by the tension odor component can be eliminated or suppressed. Persons who are or have been in tension or mental stress, or who are likely to become tension or mental stress, in advance and / or after using the inactivating agent of the present disclosure It is possible to take measures such as psychological modulation and physiological modulation.
  • the method for producing the deodorant and the deactivator of the present disclosure is not particularly limited.
  • a deodorant and an inactivating agent can be produced by mixing a deodorant component.
  • ⁇ Tension odor is an odor emitted from the body when nervous or under stress.
  • the tension or mental stress here includes, for example, tension or stress that depends on interpersonal relationships.
  • Interpersonal tension / stress is, for example, the tension / stress that is being announced in public (especially before a large number of people), the tension / stress that is undergoing an important or oppressive interview Etc.
  • the heart rate per minute is 20 bpm (beats per minute) or more, preferably 30 bpm or more higher than that at normal rest. It can be said that it is in a state.
  • Normal resting means resting without mental stress and a state in which heart rate does not fluctuate, for example, a state of sitting and relaxing for a predetermined time or longer.
  • the tension odor is considered to be based on the components contained in the blood.
  • “generation from the body (secretion / release)” means generation (secretion / release) from the skin, mucous membrane and / or oral cavity.
  • “Body odor” in the present disclosure includes bad breath.
  • the tension odor component includes a compound containing sulfur element (sulfur compound).
  • sulfur compound examples include at least one of allyl mercaptan and dimethyl trisulfide.
  • the tension odor component includes both allyl mercaptan and dimethyl trisulfide.
  • the allyl mercaptan can be 0.1 ppb or more, 0.3 ppb or more, 0.5 ppb or more, 1 ppb or more, or 10 ppb or more on a volume basis.
  • the allyl mercaptan can be 1,000 ppm or less, 100 ppm or less, 10 ppm or less, 1 ppm or less, 500 ppb or less, 100 ppb or less, or 10 ppb or less on a volume basis.
  • Dimethyl trisulfide can be 1 ppb or more, 2 ppb or more, 3 ppb or more, 5 ppb or more, 10 ppb or more, 20 ppb or more, 50 ppb or more, or 100 ppb or more on a volume basis.
  • Dimethyl trisulfide can be 10,000 ppm or less, 1,000 ppm or less, 100 ppm or less, 10 ppm or less, 1 ppm or less, 100 ppb or less, or 10 ppb or less on a volume basis.
  • the mass ratio of allyl mercaptan to dimethyl trisulfide is, for example, 2 parts by mass or more, 5 parts by mass or more, 10 parts by mass or more, or 15 parts by mass with respect to 1 part by mass of allyl mercaptan. Part or more.
  • the mass ratio of allyl mercaptan and dimethyl trisulfide is, for example, 50 parts by mass or less, 40 parts by mass or less, 30 parts by mass or less, or 25 parts by mass or less with respect to 1 part by mass of allyl mercaptan. Can do.
  • Tension odor components include hydrogen sulfide, methyl mercaptan, carbon disulfide, dimethyl sulfide, dimethyl disulfide, methylpropyl trisulfide, and these as sulfur compounds other than allyl mercaptan and dimethyl trisulfide (hereinafter referred to as “other sulfur compounds”). It may further contain at least one compound selected from the group consisting of:
  • the total amount of sulfur compounds can be 0.1 ppb or more, 1 ppb or more, or 10 ppb or more on a volume basis.
  • the total amount of sulfur compounds can be 10,000 ppm or less, or 1,000 ppm or less on a volume basis.
  • the tension odor component can contain 1-octen-3-one as a non-sulfur compound in addition to or alone with respect to the sulfur compound.
  • 1-octen-3-one can be, for example, 0.1 ppb or more, 0.5 ppb or more, 1 ppb or more, 10 ppb or more, 100 ppb or more, or 1 ppm or more on a volume basis.
  • 1-octen-3-one can be, for example, 1,000 ppm or less, 100 ppm or less, 10 ppm or less, or 1 ppm or less on a volume basis.
  • deodorant and deactivator of the present disclosure will be described below with examples. However, the deodorant and the deactivator of the present disclosure are not limited to the following examples.
  • Example 1 Deodorization test for dimethyl trisulfide
  • Deodorant 0.05 mass% and dipropylene glycol 99.95 mass% were mixed and the deodorizer solution was produced about each deodorizer.
  • 1 mL of the deodorant solution and 5 ⁇ 10 ⁇ 4 parts by mass of dimethyl trisulfide with respect to 1 part by mass of the deodorant were injected into a sample tube having a capacity of 30 ml.
  • Three expert panels sniffed the scent in the sample tube and evaluated the deodorizing effect of each deodorant on dimethyltrisulfide according to the following criteria.
  • Table 1 shows the deodorant tested and the evaluation of the deodorizing effect of each deodorant by a specialized panel.
  • the evaluation shown in Table 1 represents the average score of the specialized panel according to the following criteria.
  • the average particle size of zinc oxide used in the following examples is about 0.2 ⁇ m.
  • A 2 points; B: 1.5 points or more and less than 2 points; C: 1 point or more and less than 1.5 point; D: Less than 1 point.
  • Test Examples 1 to 5 were confirmed to have a deodorizing effect on dimethyl trisulfide, which is a causative substance of tension odor. Therefore, the deodorizers of Test Examples 1 to 5 are considered to be effective for deodorizing tension odors.
  • Example 2 Deodorization test for allyl mercaptan
  • Deodorizer 0.10 mass% and dipropylene glycol 99.90 mass% were mixed, and the deodorizer solution was produced about each deodorizer.
  • 1 mL of the deodorant solution and 5 ⁇ 10 ⁇ 6 parts by mass of allyl mercaptan with respect to 1 part by mass of the deodorant were injected into a sample tube having a capacity of 30 ml.
  • Three expert panels sniffed the scent in the sample tube, and evaluated the deodorizing effect of each deodorant on allyl mercaptan according to the following criteria.
  • Table 2 shows the deodorant tested, and the evaluation of the deodorizing effect by a specialized panel for each deodorant. The evaluation criteria are the same as in Example 1.
  • the deodorizers of Test Examples 10 to 18 were confirmed to have a deodorizing effect on allyl mercaptan, which is a causative substance of tension odor. Therefore, the deodorizers of Test Examples 10 to 18 are considered to be effective for deodorizing tension odors.
  • Example 3 Deodorization test for allyl mercaptan
  • Deodorizer 0.10 mass% and dipropylene glycol 99.90 mass% were mixed, and the deodorizer solution was produced about each deodorizer.
  • the deodorizer contains 50% by mass of zinc oxide as component A and 50% by mass of component B shown in Table 3.
  • 1 mL of the deodorant solution and 2.5 ⁇ 10 ⁇ 6 parts by mass of allyl mercaptan with respect to 1 part by mass of the deodorant were injected into a 30-ml sample tube.
  • Three expert panels sniffed the scent in the sample tube, and evaluated the deodorizing effect of each deodorant on allyl mercaptan according to the following criteria.
  • Table 3 shows the deodorant tested, and the evaluation of the deodorizing effect by a specialized panel for each deodorant. The evaluation criteria are the same as in Example 1.
  • the deodorizing effect was generally improved as compared with using the deodorant component alone. For example, comparing Test Examples 10, 16, 22, 23, and 25 shown in Table 2 with Test Examples 26, 32, 37, 38, and 40 shown in Table 3, respectively, the deodorization used in Example 2
  • the deodorizing effect could be enhanced compared to the deodorant alone.
  • laponite, hydroxypropyl- ⁇ -dextrin, sugarcane extract, loquat leaf extract, and green tea extract alone had a low deodorizing effect, but the deodorizing effect could be enhanced by mixing with zinc oxide. That is, these deodorizing components and zinc oxide are considered to have a synergistic effect of deodorization.
  • the deodorizing effect could be improved by increasing the amount of zinc oxide with respect to the malodor-causing substance. From this, if the application amount of a deodorizer is increased with respect to a tension odor, the deodorizing effect can be improved more.
  • Example 4 Deodorization test for tension odor model composition
  • Deodorants shown in Table 4 containing zinc oxide as component A and hydroxypropyl- ⁇ -dextrin as component B were prepared.
  • the tension odor model composition containing the tension odor component shown in Table 5 was produced.
  • 100 ⁇ L of the tension odor model composition and 10 ⁇ L of the deodorant were mixed in a 100 mL sealed glass container. Then, after the sealed glass container was allowed to stand for 10 minutes, the gas components present in the upper space of the sealed glass container were directly analyzed by mass spectrometry.
  • Example 5 Psychological / mental effect test
  • the subject was sniffed with a tension odor model composition, and the psychological and mental changes of the subject due to the tension odor were confirmed using POMS (registered trademark) and GACL. As a result, it was confirmed that when the subject smells a tense odor, arousal, fatigue and confusion occur.
  • each subject continued to sniff the tension odor for 5 minutes using the lowest concentration model composition that each subject could recognize. After that, he asked me to answer the same question as in Exam 1. This inspection is referred to as “inspection 2”.
  • the deodorant of the present disclosure can remove the tension odor component. Therefore, according to the deodorant of this indication, it turned out that the negative psychological and mental action resulting from a tension odor can be inactivated (cancellation, reduction, and / or relaxation). That is, it was found that the deodorant of the present disclosure can be applied as an inactivating agent for the psychological and mental effects of a tension odor.

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Abstract

Provided are: a deodorant for deodorizing stress odor; and a deactivating agent for deactivating psychological or mental activity induced by stress odor. The deodorant and the deactivating agent contain at least one among a first deodorant component and a second deodorant component. The first deodorant component includes at least one selected from a first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Cassumunar extract, Lempuyang extract, and combinations thereof. The second deodorant component includes at least one selected from a second group consisting of laponite, silver-supported zeolite, zinc oxide, Neem leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin, Hedychium Spicatum extract, tocopherol, and combinations thereof.

Description

消臭剤及び不活性化剤Deodorant and deactivator 関連出願Related applications
 本発明は、日本国特許出願:特願2018-100599号(2018年5月25日出願)の優先権主張に基づくものであり、同出願の全記載内容は引用をもって本書に組み込み記載されているものとする。 The present invention is based on the priority claim of Japanese patent application: Japanese Patent Application No. 2018-100599 (filed on May 25, 2018), the entire contents of which are incorporated herein by reference. Shall.
 本開示は、体臭に起因する不快さを解消する又は軽減する消臭剤に関する。本開示は、人体からの分泌成分による生理的/心理的活性(変調)作用を不活性化する不活性化剤に関する。 The present disclosure relates to a deodorant that eliminates or reduces discomfort caused by body odor. The present disclosure relates to an inactivating agent that inactivates a physiological / psychological activity (modulation) action by a secretory component from a human body.
 人体の皮膚から発せられる臭気成分による臭いの多くは、不快に感じる臭いであり、一般的には「体臭」と呼ばれている。例えば、中高年に特有の体臭として「加齢臭」が知られている(例えば、特許文献1参照)。加齢臭による不愉快さを解消するため、特許文献1に記載の加齢臭抑制香料組成物には、加齢臭に対するマスキング効果に優れる成分及び/又は加齢臭に対するハーモナージュ効果に優れる成分が配合されている。 Many of the odors caused by odorous components emitted from human skin are unpleasant odors and are generally called “body odors”. For example, “aging odor” is known as a body odor peculiar to middle-aged and elderly people (see, for example, Patent Document 1). In order to eliminate the unpleasantness due to the aging odor, the aging odor suppressing fragrance composition described in Patent Document 1 has a component excellent in the masking effect on the aging odor and / or a component excellent in the harmony effect on the aging odor. It is blended.
 また、一般的に、硫黄化合物は不快臭成分であると考えられている。特許文献2には、2-メチルブタン酸ブチル、α-テルピネン、ジペンテン、cis-4-ヘプテナール、1,4-シネオール、トリメチルヘキシルアルデヒド及び(+)-リモネンオキシドからなる群より選択される少なくとも1種を有効成分とする、ポリスルフィド化合物の臭いの抑制剤が開示されている。 In general, sulfur compounds are considered to be unpleasant odor components. Patent Document 2 discloses at least one selected from the group consisting of butyl 2-methylbutanoate, α-terpinene, dipentene, cis-4-heptenal, 1,4-cineole, trimethylhexylaldehyde, and (+)-limonene oxide. An inhibitor of the odor of a polysulfide compound is disclosed which contains as an active ingredient.
特開平11-286428号公報Japanese Patent Laid-Open No. 11-286428 WO2016/204212A1WO2016 / 204212A1
 本発明者らは、精神的ストレスによって心拍数が上がるような緊張状態(ストレス状態)にある人の周囲に特有の臭いがあることに気が付いた。そこで、本発明者らは、その臭いの原因について研究したところ、その臭いは、緊張状態又は精神的ストレス状態にある人から分泌・放出される物質に起因する体臭(以下、本開示において「緊張臭」又は「ストレス臭」と称する。)であることが判明した。 The present inventors have noticed that there is a peculiar smell around a person who is in a tension state (stress state) in which the heart rate increases due to mental stress. Therefore, the present inventors have studied the cause of the odor. The odor is a body odor caused by a substance secreted / released from a person in a tension state or a mental stress state (hereinafter referred to as “tension” in this disclosure). Odor "or" stress odor ").
 この緊張臭は、硫黄系の臭いであり、多くの人が不快に感じるであろう臭いである。近年、体臭への関心が高まっていることもあり、緊張臭に起因する不快感を解消又は低減可能な消臭剤に対する需要が高まることが予想される。 This tension odor is a sulfur-based odor that many people will feel uncomfortable. In recent years, interest in body odor has increased, and it is expected that demand for deodorants that can eliminate or reduce discomfort caused by tension odor will increase.
 特許文献2に記載の臭いの抑制剤は、排水口や生ごみ等の人体以外からの悪臭についてのみ言及しており、人体から発する悪臭については検討されておらず、特許文献2に記載の臭いの抑制剤では緊張臭を抑制できるか不明である。 The odor suppressor described in Patent Document 2 refers only to bad odors other than the human body such as drain outlets and garbage, and has not been studied for bad odors emitted from the human body, and the odor described in Patent Document 2 It is unclear whether the suppressor can suppress the tension odor.
 緊張状態又精神的ストレス状態にある人から分泌、放出される成分(例えば、緊張臭の原因物質)には、生理的活性作用及び心理的活性作用のうちの少なくとも一方があると本発明者は考えている。そこで、緊張状態又精神的ストレス状態にある人から分泌される成分(以下、「緊張臭成分」と称する。)による生理的活性作用及び/又は心理的活性作用を不活性化する不活性剤に対する需要が高まることが予想される。 The present inventor believes that a component secreted and released from a person who is in a tension state or mental stress state (for example, a causative substance of a tension odor) has at least one of a physiologically active action and a psychologically active action. thinking. Therefore, for an inactive agent that inactivates a physiologically active action and / or a psychologically active action by a component secreted from a person in tension or mental stress (hereinafter referred to as “tension odor component”). Demand is expected to increase.
 本開示の第1視点によれば、第1の消臭成分及び第2の消臭成分のうち少なくとも1つを含む緊張臭消臭剤が提供される。第1の消臭成分は、銀担持ゼオライト、トコフェロール、酸化亜鉛、カムスナールエキス、ルムプヤンエキス、及びこれらの組合せからなる第1の群から選択される少なくとも1つを含む。第2の消臭成分は、ラポナイト、銀担持ゼオライト、酸化亜鉛、ニームリーフエキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、トコフェロール、及びこれらの組合せからなる第2の群から選択される少なくとも1つを含む。 According to the first aspect of the present disclosure, a tension odor deodorant containing at least one of the first deodorant component and the second deodorant component is provided. The first deodorizing component includes at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Camsnar extract, Lumpuyan extract, and combinations thereof. The second deodorant component is composed of laponite, silver supported zeolite, zinc oxide, neem leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin, sanna extract, tocopherol, and combinations thereof. Including at least one selected from the group.
 本開示の第2視点によれば、第1の消臭成分及び第2の消臭成分のうち少なくとも1つを含む緊張臭消臭剤が提供される。第1の消臭成分は、銀担持ゼオライト、トコフェロール、酸化亜鉛、カムスナールエキス、ルムプヤンエキス、及びこれらの組合せからなる第1の群から選択される少なくとも1つを含む。第2の消臭成分は、酸化亜鉛と、ラポナイト、銀担持ゼオライト、ジブチルヒドロキシトルエン、サトウキビエキス、ビワ葉エキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、緑茶エキス、及びこれらの組合せからなる第3の群から選択される少なくとも1つと、を含む。 According to the second aspect of the present disclosure, a tension odor deodorant containing at least one of the first deodorant component and the second deodorant component is provided. The first deodorizing component includes at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Camsnar extract, Lumpuyan extract, and combinations thereof. The second deodorant component is zinc oxide, laponite, silver-supported zeolite, dibutylhydroxytoluene, sugarcane extract, loquat leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin, sanna extract, green tea extract, And at least one selected from the third group consisting of combinations thereof.
 本開示の第3視点によれば、第1の消臭成分及び第2の消臭成分のうち少なくとも1つを含む不活性化剤が提供される。第1の不活性化成分は、銀担持ゼオライト、トコフェロール、酸化亜鉛、カムスナールエキス、ルムプヤンエキス、及びこれらの組合せからなる第1の群から選択される少なくとも1つを含む。第2の不活性化成分は、ラポナイト、銀担持ゼオライト、酸化亜鉛、ニームリーフエキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、トコフェロール、及びこれらの組合せからなる第2の群から選択される少なくとも1つを含む。不活性化剤は、分泌成分の心理的又は精神的活性作用を不活性化する。 According to the third aspect of the present disclosure, an inactivating agent including at least one of the first deodorizing component and the second deodorizing component is provided. The first inactivating component includes at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Camsnar extract, Lumpuyan extract, and combinations thereof. The second inactivating component is composed of laponite, silver-supported zeolite, zinc oxide, neem leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin, sanna extract, tocopherol, and combinations thereof. At least one selected from the group of: Inactivators inactivate the psychological or psychoactive activity of secretory components.
 本開示の第4視点によれば、第1の消臭成分及び第2の消臭成分のうち少なくとも1つを含む不活性化剤が提供される。第1の不活性化剤成分は、銀担持ゼオライト、トコフェロール、酸化亜鉛、カムスナールエキス、ルムプヤンエキス、及びこれらの組合せからなる第1の群から選択される少なくとも1つを含む。第2の不活性化剤成分は、酸化亜鉛と、ラポナイト、銀担持ゼオライト、ジブチルヒドロキシトルエン、サトウキビエキス、ビワ葉エキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、緑茶エキス、及びこれらの組合せからなる第3の群から選択される少なくとも1つと、を含む。不活性化剤は、分泌成分の心理的又は精神的活性作用を不活性化する。 According to the fourth aspect of the present disclosure, an inactivating agent including at least one of the first deodorant component and the second deodorant component is provided. The first deactivator component includes at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, camsnar extract, lumpyan extract, and combinations thereof. The second deactivator component is zinc oxide, laponite, silver supported zeolite, dibutylhydroxytoluene, sugarcane extract, loquat leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin, sanna extract, green tea And at least one selected from a third group consisting of extracts and combinations thereof. Inactivators inactivate the psychological or psychoactive activity of secretory components.
 本開示の消臭剤によれば、緊張臭に基づく不快感を解消ないし軽減することができる。 </ RTI> According to the deodorant of the present disclosure, it is possible to eliminate or reduce discomfort based on a tension odor.
 本開示の不活性化剤によれば、緊張臭成分による心理的又は生理的活性作用を不活性化又は抑制することができる。 According to the inactivating agent of the present disclosure, it is possible to inactivate or suppress the psychological or physiological activity action by the tension odor component.
実施例4における結果を示すグラフ。The graph which shows the result in Example 4.
 上記各視点の好ましい形態を以下に記載する。 Favorable forms from the above viewpoints are described below.
 上記第1及び第2視点の好ましい形態によれば、緊張臭は、緊張状態及び/又は精神的ストレスに起因して体内から発せられる臭いである。 According to the preferred embodiments of the first and second aspects, the tension odor is an odor emitted from the body due to a tension state and / or mental stress.
 上記第1及び第2視点の好ましい形態によれば、緊張臭の原因物質が、アリルメルカプタン及びジメチルトリスルフィドのうちの少なくとも1つを含む。 According to a preferred form of the first and second aspects, the causative substance of the tension odor includes at least one of allyl mercaptan and dimethyl trisulfide.
 上記第1及び第2視点の好ましい形態によれば、原因物質が、メチルメルカプタン、ジメチルスルフィド、ジメチルジスルフィド、及びこれらの組合せからなる群から選択される少なくとも1つの化合物をさらに含有する。 According to a preferred form of the first and second aspects, the causative substance further contains at least one compound selected from the group consisting of methyl mercaptan, dimethyl sulfide, dimethyl disulfide, and combinations thereof.
 上記第1及び第2視点の好ましい形態によれば、原因物質が、1-オクテン-3-オンをさらに含む。 According to a preferred form of the first and second aspects, the causative substance further includes 1-octen-3-one.
 上記第3及び第4視点の好ましい形態によれば、分泌成分は、緊張状態及び/又は精神的ストレスに起因して体内から分泌される成分である。 According to a preferred form of the third and fourth viewpoints, the secretory component is a component secreted from the body due to tension and / or mental stress.
 上記第3及び第4視点の好ましい形態によれば、分泌成分が、アリルメルカプタン及びジメチルトリスルフィドのうちの少なくとも1つを含む。 According to a preferred form of the third and fourth aspects, the secretory component contains at least one of allyl mercaptan and dimethyl trisulfide.
 上記第3及び第4視点の好ましい形態によれば、分泌成分が、メチルメルカプタン、ジメチルスルフィド、ジメチルジスルフィド、及びこれらの組合せからなる群から選択される少なくとも1つの化合物をさらに含有する。 According to a preferred form of the third and fourth aspects, the secretory component further contains at least one compound selected from the group consisting of methyl mercaptan, dimethyl sulfide, dimethyl disulfide, and combinations thereof.
 上記第3及び第4視点の好ましい形態によれば、分泌成分が、1-オクテン-3-オンをさらに含む。 According to a preferred form of the third and fourth aspects, the secretory component further contains 1-octen-3-one.
 本開示の第1実施形態に係る消臭剤について説明する。 Deodorant according to the first embodiment of the present disclosure will be described.
 本開示の消臭剤は、人が緊張状態及び/又は精神的ストレス状態にあるときに発せられる体臭(緊張臭)に対して好適に適用可能な消臭剤である。本開示における消臭剤は、消臭したい臭い(以下、「悪臭」と称する)の原因物質に対する化学的作用及び/又は物理的作用によって悪臭を除去又は緩和するものをいう。なお、本開示に挙げた成分が、化学的作用及び/又は物理的作用以外によって悪臭を除去又は緩和していたとしても、本開示の消臭剤の範囲外となるものではない。 The deodorant of the present disclosure is a deodorant that can be suitably applied to body odor (tension odor) emitted when a person is in a tension state and / or a mental stress state. The deodorant in the present disclosure refers to a substance that removes or reduces malodor by a chemical action and / or a physical action on a causative substance of a smell to be deodorized (hereinafter referred to as “bad odor”). In addition, even if the components listed in the present disclosure remove or mitigate malodors other than by chemical action and / or physical action, they do not fall outside the scope of the deodorant of the present disclosure.
 本開示の消臭剤は、第1の消臭成分及び第2の消臭成分のうち少なくとも1つを含む。 The deodorizer of the present disclosure includes at least one of a first deodorant component and a second deodorant component.
 第1の消臭成分は、銀担持ゼオライト、トコフェロール、酸化亜鉛(粉末)、カムスナールエキス、ルムプヤンエキス、及びこれらの組合せからなる第1の群から選択される少なくとも1つを含むことができる。第1の消臭成分は、緊張臭の原因物質のうち、特にアリルメルカプタンに起因する悪臭の消臭に有用であると考えられる。 The first deodorant component can include at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide (powder), Kamsnar extract, Lumpuyan extract, and combinations thereof. The first deodorant component is considered to be useful for deodorizing malodor caused by allyl mercaptan among causative substances of tension odor.
 本開示において、銀担持ゼオライトとは、例えば、ゼオライト中のイオン交換可能なイオンの少なくとも一部を銀イオンで置換されたものを含む。銀担持ゼオライト中の銀イオン含有率は、例えば、0.1質量%~15質量%とすることができる。 In the present disclosure, the silver-supported zeolite includes, for example, one in which at least a part of ion-exchangeable ions in the zeolite is replaced with silver ions. The silver ion content in the silver-supported zeolite can be, for example, 0.1% by mass to 15% by mass.
 第2の消臭成分は、ラポナイト、銀担持ゼオライト、酸化亜鉛、ニームリーフエキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、トコフェロール、ジブチルヒドロキシトルエン、サトウキビエキス、ビワ葉エキス、緑茶エキス、及びこれらの組合せからなる第2の群から選択される少なくとも1つを含むことができる。第2の消臭成分は、緊張臭の原因物質のうち、特にジメチルトリスルフィドに起因する悪臭の消臭に有用であると考えられる。 The second deodorant component is laponite, silver supported zeolite, zinc oxide, neem leaf extract, iris leaf extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin, sanna extract, tocopherol, dibutylhydroxytoluene, sugarcane extract, loquat leaf It may comprise at least one selected from the second group consisting of extracts, green tea extracts, and combinations thereof. The second deodorizing component is considered to be useful for deodorizing malodor caused by dimethyl trisulfide, among substances causing tension odor.
 第2の消臭成分は、(A)酸化亜鉛と、(B)ラポナイト、銀担持ゼオライト、ジブチルヒドロキシトルエン、サトウキビエキス、ビワ葉エキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、緑茶エキス、及びこれらの組合せからなる第3の群から選択される少なくとも1つと、を含むと好ましい。この組み合わせによると、緊張臭の消臭効果をより高めることができる。 The second deodorant component is (A) zinc oxide and (B) laponite, silver-supported zeolite, dibutylhydroxytoluene, sugarcane extract, loquat leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin , Sanna extract, green tea extract, and at least one selected from the third group consisting of combinations thereof. According to this combination, the deodorizing effect of the tension odor can be further enhanced.
 酸化亜鉛は、微細な粉末を使用することができる。酸化亜鉛の平均粒径は、例えば、5μm以下、3μm以下、2μm以下、1μm以下、又は0.5μm以下とすることができる。 Zinc oxide can be fine powder. The average particle diameter of zinc oxide can be, for example, 5 μm or less, 3 μm or less, 2 μm or less, 1 μm or less, or 0.5 μm or less.
 緊張臭の原因物質の主成分は、後述するように、アリルメルカプタン及びジメチルトリスルフィドである。両物質は、嗅覚への影響が特に大きい。したがって、アリルメルカプタン及びジメチルトリスルフィドの臭いを消臭すれば、緊張臭を効果的に消臭することができる。 The main components of the causative substance of the tension odor are allyl mercaptan and dimethyl trisulfide, as will be described later. Both substances have a particularly large impact on the sense of smell. Therefore, if the odors of allyl mercaptan and dimethyl trisulfide are eliminated, the tension odor can be effectively eliminated.
 本開示の消臭剤の使用方法及び緊張臭の消臭方法について説明する。 The method of using the deodorant of the present disclosure and the method of deodorizing tension odor will be described.
 本開示の消臭剤は、緊張臭が発生している場所及び/又は発生する可能性がある場所に、事前に及び/又は事後に空気中に散布することができる。消臭剤は、衣服、カーテン、じゅうたん等の布製品に事前に及び/又は事後に付着ないし散布することもできる。消臭剤が肌に悪影響を及ぼさない場合には、事前に及び/又は事後に消臭剤を肌に塗布することができる。例えば、緊張臭成分を分泌すると考えられる箇所、例えば、手のひら、脇、足、背中、頭部、顔、口腔等に消臭剤を塗布することができる。 The deodorant of the present disclosure can be sprayed in the air in advance and / or after the event to a place where a tension odor is generated and / or a place where the tension odor may be generated. The deodorant can be attached or spread on cloth products such as clothes, curtains and carpets in advance and / or after the fact. If the deodorant does not adversely affect the skin, the deodorant can be applied to the skin in advance and / or after the fact. For example, a deodorant can be applied to a place where a tension odor component is considered to be secreted, for example, palm, armpit, foot, back, head, face, oral cavity, and the like.
 本開示の消臭剤は、他の消臭剤、化学的・生物的・物理的作用等で悪臭を除去又は緩和するもの等と組み合わせて使用することができる。例えば、本開示の消臭剤は、本開示の消臭剤の効果を阻害しない範囲において、防臭成分、脱臭成分、他の消臭成分等をさらに含有することができる。 The deodorant of the present disclosure can be used in combination with other deodorants, those that remove or mitigate bad odors by chemical, biological, physical action and the like. For example, the deodorant of the present disclosure can further contain a deodorizing component, a deodorizing component, another deodorizing component, and the like as long as the effect of the deodorant of the present disclosure is not impaired.
 本開示の消臭剤によれば、緊張臭を嗅いだ際に生ずることになる不快感を解消ないし抑制することができる。また、緊張状態又は精神的ストレス状態にある人もしくはあった人、又はこれから緊張状態又は精神的ストレス状態となるおそれのある人は、本開示の消臭剤を用いることによって、緊張臭を発生させているかもしれないという不安感、緊張臭を発生させるかもしれないという不安感を事前及び/又は事後に解消ないし低減することができる。 The deodorant according to the present disclosure can eliminate or suppress the discomfort that occurs when smelling a tense odor. Moreover, a person who is or has been in a tension state or a mental stress state, or a person who is likely to become a tension state or a mental stress state in the future generates a tension odor by using the deodorant of the present disclosure. It is possible to eliminate or reduce the anxiety that it may have occurred and the anxiety that it may generate a tense odor in advance and / or after the fact.
 本開示の第2実施形態に係る不活性化剤について説明する。 The deactivating agent according to the second embodiment of the present disclosure will be described.
 緊張臭成分は、人に対して心理的活性作用及び生理的活性作用のうちのすくなくとも一方を有している。例えば、人が緊張臭を感知した場合、嗅覚受容体が緊張臭成分に応答した場合等には、その人は、精神的に疲労したり、混乱したり、覚醒したりすることが明らかになりつつある。緊張臭成分には、これら以外の精神的活性作用及び/又は心理的活性作用がある可能性もある。本開示の不活性化剤は、緊張臭成分のこのような精神的活性作用及び/又は心理的活性作用を不活性化する作用がある。すなわち、人が本開示の不活性化剤の香りを感知した場合、不活性化剤の香りと緊張臭とを混合して嗅いだ場合、嗅覚受容体が不活性化剤に応答した場合等に、その人は、上記のような精神的変調及び/又は心理的変調を解消ないし抑制することができる。 The tension odor component has at least one of a psychological activity and a physiological activity on humans. For example, when a person senses a tense odor, or when an olfactory receptor responds to a tense odor component, it becomes clear that the person is mentally fatigued, confused, or awakened. It's getting on. The tension odor component may have a psychoactive activity and / or psychological activity other than these. The inactivating agent of the present disclosure has an effect of inactivating such a mental activity and / or psychological activity of the tension odor component. That is, when a person senses the scent of the inactivation agent of the present disclosure, mixes and smells the scent of the inactivation agent and a tension odor, or when the olfactory receptor responds to the inactivation agent, etc. The person can eliminate or suppress the mental modulation and / or psychological modulation as described above.
 特に、人が緊張臭を知覚すると、ネガティブな感情が高まることが明らかになった。また、ポジティブな感情が低下する傾向があることも明らかになった。ネガティブな感情としては、例えば、POMS(登録商標)(Profile of Mood States)検査に基づく「怒り・敵意」、「混乱・当惑」、「抑うつ・落込み」、「疲労・無気力」及び「緊張・不安」が挙げられる。緊張臭は、このうち「混乱・当惑」、「疲労・無気力」及び「緊張・不安」を特に高めることが分かった。また、ポジティブな感情としては、例えば、「活気・活力」及び「友好」が挙げられる。 Especially, it became clear that negative emotions increased when people perceived a tense odor. It also became clear that positive emotions tend to decline. Negative emotions include, for example, “anger / hostility”, “confused / embarrassed”, “depressed / depressed”, “fatigue / impotence”, and “tension / impotence” based on the POMS (Profile of Mood States) test. Anxiety ”is mentioned. It has been found that the tension odor particularly increases “confused / embarrassed”, “fatigue / apathy” and “tension / anxiety”. Positive emotions include, for example, “liveliness / energy” and “friendship”.
 本開示の不活性化剤は、第1の不活性化成分及び第2の不活性化成分のうち少なくとも1つを含む。 The deactivating agent of the present disclosure includes at least one of a first deactivating component and a second deactivating component.
 第1の不活性化成分は、銀担持ゼオライト、トコフェロール、酸化亜鉛、カムスナールエキス、ルムプヤンエキス、及びこれらの組合せからなる第1の群から選択される少なくとも1つを含むことができる。第1の不活性化成分は、緊張臭の原因物質のうち、特にアリルメルカプタンに起因する悪臭の不活性化に有用であると考えられる。 The first deactivating component can include at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Kamsnar extract, Lumpuyan extract, and combinations thereof. The first inactivating component is considered to be useful for inactivating malodor caused by allyl mercaptan among causative substances of tension odor.
 第2の不活性化成分は、ラポナイト、銀担持ゼオライト、酸化亜鉛、ニームリーフエキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、トコフェロール、ジブチルヒドロキシトルエン、サトウキビエキス、ビワ葉エキス、緑茶エキス、及びこれらの組合せからなる第2の群から選択される少なくとも1つを含むことができる。第2の不活性化成分は、緊張臭の原因物質のうち、特にジメチルトリスルフィドに起因する悪臭の不活性化に有用であると考えられる。 The second inactivating component is laponite, silver supported zeolite, zinc oxide, neem leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin, sanna extract, tocopherol, dibutylhydroxytoluene, sugarcane extract, loquat At least one selected from the second group consisting of leaf extract, green tea extract, and combinations thereof may be included. The second inactivating component is considered to be useful for inactivating malodor caused by dimethyl trisulfide, among the causative substances of tension odor.
 第2の不活性化成分は、(A)酸化亜鉛と、(B)ラポナイト、銀担持ゼオライト、ジブチルヒドロキシトルエン、サトウキビエキス、ビワ葉エキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、緑茶エキス、及びこれらの組合せからなる第3の群から選択される少なくとも1つと、を含むと好ましい。この組み合わせによると、緊張臭の不活性化効果をより高めることができる。 The second inactivating component is (A) zinc oxide and (B) laponite, silver-supported zeolite, dibutylhydroxytoluene, sugarcane extract, loquat leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclo Preferably, at least one selected from a third group consisting of dextrin, sanna extract, green tea extract, and combinations thereof. According to this combination, the tension odor inactivating effect can be further enhanced.
 酸化亜鉛は、微細な粉末を使用することができる。酸化亜鉛の平均粒径は、例えば、5μm以下、3μm以下、2μm以下、1μm以下、又は0.5μm以下とすることができる。 Zinc oxide can be fine powder. The average particle diameter of zinc oxide can be, for example, 5 μm or less, 3 μm or less, 2 μm or less, 1 μm or less, or 0.5 μm or less.
 緊張臭成分による心理的活性作用及び生理的活性作用、並びに不活性剤による緊張臭成分の不活性化作用は、例えば、心理質問紙を用いる方法、例えば、POMS(登録商標)(Profile of Mood States)、GACL(General Activity Checklist)等を用いて調べることができる。 Psychologically active and physiologically active effects due to the tension odor component, and inactivation of the tension odor component due to the inactive agent are, for example, a method using a psychological questionnaire such as POMS (registered trademark) (Profile of Mood States). ), GACL (General Activity Checklist) or the like.
 緊張臭の原因物質の主成分は、後述するように、アリルメルカプタン及びジメチルトリスルフィドである。両物質は、嗅覚への影響が特に大きい。したがって、アリルメルカプタン及びジメチルトリスルフィドの臭いを消臭すれば、緊張臭による心理的及び/又は生理的活性作用を効果的に不活性化することができる。 The main components of the causative substance of the tension odor are allyl mercaptan and dimethyl trisulfide, as will be described later. Both substances have a particularly large impact on the sense of smell. Therefore, if the odors of allyl mercaptan and dimethyl trisulfide are eliminated, the psychological and / or physiologically active action due to the tension odor can be effectively inactivated.
 本開示の不活性化剤の使用方法及び緊張臭成分の不活性化方法について説明する。 The method for using the deactivating agent of the present disclosure and the method for deactivating the tension odor component will be described.
 本開示の不活性化剤は、緊張臭成分が発生している場所及び/又は発生する可能性がある場所に、事前に及び/又は事後に空気中に散布することができる。不活性化剤は、衣服、カーテン、じゅうたん等の布製品に事前に及び/又は事後に付着ないし散布することもできる。不活性化剤が肌に悪影響を及ぼさない場合には、事前に及び/又は事後に不活性化剤を肌に塗布することができる。例えば、緊張臭成分を分泌すると考えられる箇所、例えば、手のひら、脇、足、背中、頭部、顔、口腔等に不活性化剤を塗布することができる。 The inactivating agent of the present disclosure can be sprayed in the air in advance and / or after the event in a place where a tension odor component is generated and / or a place where it may be generated. The deactivator can also be applied or spread on fabric products such as clothes, curtains and carpets in advance and / or after the fact. If the deactivator does not adversely affect the skin, the deactivator can be applied to the skin in advance and / or after the fact. For example, the deactivator can be applied to a part that is considered to secrete a tense odor component, such as the palm, armpit, foot, back, head, face, oral cavity, and the like.
 本開示の不活性化剤は、他の心理的・生理的作用不活性化剤等と組み合わせて使用することができる。例えば、本開示の不活性化剤は、本開示の不活性化剤の効果を阻害しない範囲において、他の不活性化剤をさらに含有することができる。他の不活性化剤としては、例えば、悪臭(例えば緊張臭)に対して化学的・生物的・物理的作用等で悪臭を除去又は緩和するもの(例えば、防臭成分、消臭成分、脱臭成分等)が挙げられる。 The inactivating agent of the present disclosure can be used in combination with other psychological and physiological action inactivating agents and the like. For example, the inactivation agent of the present disclosure may further contain another inactivation agent as long as the effect of the inactivation agent of the present disclosure is not inhibited. Other deactivators include, for example, those that remove or mitigate malodors by chemical, biological, physical action, etc. against malodors (eg, tension odors) (eg, deodorant components, deodorant components, deodorant components) Etc.).
 本開示の不活性化剤は、緊張臭成分の精神的活性作用及び/又は心理的活性作用を不活性化させることができる。これにより、緊張臭成分に起因する心理的変調、生理的変調等を解消ないし抑制することができる。緊張状態又は精神的ストレス状態にある人もしくはあった人、又はこれから緊張状態又は精神的ストレス状態となるおそれのある人は、本開示の不活性化剤を用いることによって、事前に及び/又は事後に心理的変調、生理的変調等の対策を採ることができる。 The inactivating agent of the present disclosure can inactivate the mental activity and / or psychological activity of the tension odor component. Thereby, psychological modulation, physiological modulation, and the like caused by the tension odor component can be eliminated or suppressed. Persons who are or have been in tension or mental stress, or who are likely to become tension or mental stress, in advance and / or after using the inactivating agent of the present disclosure It is possible to take measures such as psychological modulation and physiological modulation.
 本開示の消臭剤及び不活性化剤の製造方法は特に限定されない。例えば、消臭成分を混合することによって消臭剤及び不活性化剤を製造することができる。 The method for producing the deodorant and the deactivator of the present disclosure is not particularly limited. For example, a deodorant and an inactivating agent can be produced by mixing a deodorant component.
 本開示にいう緊張臭及び緊張臭成分について説明する。 The tension odor and the tension odor component referred to in the present disclosure will be described.
 緊張臭とは、緊張しているとき、あるいは精神的ストレスが掛かっているときに体内から発せられる臭いである。ここでいう緊張又は精神的ストレスには、例えば、対人関係に依拠する緊張又はストレス等が挙げられる。対人に依拠する緊張・ストレスとは、例えば、人前(特に大人数の前)で発表している最中の緊張・ストレス、大切な面接や圧迫的な面接を受けている最中の緊張・ストレス等が挙げられる。このような精神的ストレス状態は、例えば、運動に起因する心拍数上昇が無い場合には、1分間当たりの心拍数が平常安静時よりも20bpm(beats per minute)以上、好ましくは30bpm以上高くなっている状態ということもできる。平常安静時とは、精神的ストレスなく安静にして心拍数の変動の少ない状態、例えば所定時間以上座ってリラックスした状態、をいう。 ¡Tension odor is an odor emitted from the body when nervous or under stress. The tension or mental stress here includes, for example, tension or stress that depends on interpersonal relationships. Interpersonal tension / stress is, for example, the tension / stress that is being announced in public (especially before a large number of people), the tension / stress that is undergoing an important or oppressive interview Etc. In such a mental stress state, for example, when there is no heart rate increase due to exercise, the heart rate per minute is 20 bpm (beats per minute) or more, preferably 30 bpm or more higher than that at normal rest. It can be said that it is in a state. Normal resting means resting without mental stress and a state in which heart rate does not fluctuate, for example, a state of sitting and relaxing for a predetermined time or longer.
 緊張臭は、は血中に含まれていた成分に基づいていると考えられている。本開示において、「体内から発生(分泌・放出)」とは、皮膚、粘膜及び/又は口腔から発生(分泌・放出)することを意味する。本開示にいう「体臭」には口臭も含まれる。 The tension odor is considered to be based on the components contained in the blood. In the present disclosure, “generation from the body (secretion / release)” means generation (secretion / release) from the skin, mucous membrane and / or oral cavity. “Body odor” in the present disclosure includes bad breath.
 緊張臭成分は、硫黄元素を含有する化合物(硫黄化合物)を含む。硫黄化合物としては、アリルメルカプタン及びジメチルトリスルフィドのうちの少なくとも1つが挙げられる。好ましくは、緊張臭成分は、アリルメルカプタン及びジメチルトリスルフィドの両方を含む。 The tension odor component includes a compound containing sulfur element (sulfur compound). Examples of the sulfur compound include at least one of allyl mercaptan and dimethyl trisulfide. Preferably, the tension odor component includes both allyl mercaptan and dimethyl trisulfide.
 アリルメルカプタンは、体積基準で、0.1ppb以上、0.3ppb以上、0.5ppb以上、1ppb以上、又は10ppb以上であることができる。アリルメルカプタンは、体積基準で、1,000ppm以下、100ppm以下、10ppm以下、1ppm以下、500ppb以下、100ppb以下、又は10ppb以下であることができる。 The allyl mercaptan can be 0.1 ppb or more, 0.3 ppb or more, 0.5 ppb or more, 1 ppb or more, or 10 ppb or more on a volume basis. The allyl mercaptan can be 1,000 ppm or less, 100 ppm or less, 10 ppm or less, 1 ppm or less, 500 ppb or less, 100 ppb or less, or 10 ppb or less on a volume basis.
 ジメチルトリスルフィドは、体積基準で、1ppb以上、2ppb以上、3ppb以上、5ppb以上、10ppb以上、20ppb以上、50ppb以上、又は100ppb以上であることができる。ジメチルトリスルフィドは、体積基準で、10,000ppm以下、1,000ppm以下、100ppm以下、10ppm以下、1ppm以下、100ppb以下、又は10ppb以下であることができる。 Dimethyl trisulfide can be 1 ppb or more, 2 ppb or more, 3 ppb or more, 5 ppb or more, 10 ppb or more, 20 ppb or more, 50 ppb or more, or 100 ppb or more on a volume basis. Dimethyl trisulfide can be 10,000 ppm or less, 1,000 ppm or less, 100 ppm or less, 10 ppm or less, 1 ppm or less, 100 ppb or less, or 10 ppb or less on a volume basis.
 緊張臭成分において、アリルメルカプタンとジメチルトリスルフィドの質量比は、例えば、アリルメルカプタン1質量部に対して、ジメチルトリスルフィドは、2質量部以上、5質量部以上、10質量部以上、又は15質量部以上であることができる。アリルメルカプタンとジメチルトリスルフィドの質量比は、例えば、アリルメルカプタン1質量部に対して、ジメチルトリスルフィドは、50質量部以下、40質量部以下、30質量部以下、又は25質量部以下であることができる。 In the tension odor component, the mass ratio of allyl mercaptan to dimethyl trisulfide is, for example, 2 parts by mass or more, 5 parts by mass or more, 10 parts by mass or more, or 15 parts by mass with respect to 1 part by mass of allyl mercaptan. Part or more. The mass ratio of allyl mercaptan and dimethyl trisulfide is, for example, 50 parts by mass or less, 40 parts by mass or less, 30 parts by mass or less, or 25 parts by mass or less with respect to 1 part by mass of allyl mercaptan. Can do.
 緊張臭成分は、アリルメルカプタン及びジメチルトリスルフィド以外の硫黄化合物(以下「その他硫黄化合物」という。)として、硫化水素、メチルメルカプタン、二硫化炭素、ジメチルスルフィド、ジメチルジスルフィド、メチルプロピルトリスルフィド、及びこれらの組合せからなる群から選択される少なくとも1つの化合物をさらに含有することがある。硫黄化合物の総量は、体積基準で、0.1ppb以上、1ppb以上、又は10ppb以上であることができる。硫黄化合物の総量は、体積基準で、10,000ppm以下、又は1,000ppm以下とであることができる。 Tension odor components include hydrogen sulfide, methyl mercaptan, carbon disulfide, dimethyl sulfide, dimethyl disulfide, methylpropyl trisulfide, and these as sulfur compounds other than allyl mercaptan and dimethyl trisulfide (hereinafter referred to as “other sulfur compounds”). It may further contain at least one compound selected from the group consisting of: The total amount of sulfur compounds can be 0.1 ppb or more, 1 ppb or more, or 10 ppb or more on a volume basis. The total amount of sulfur compounds can be 10,000 ppm or less, or 1,000 ppm or less on a volume basis.
 緊張臭成分は、非硫黄化合物として、硫黄化合物に対して追加的に又は単独で、1-オクテン-3-オンを含有することができる。1-オクテン-3-オンは、体積基準で、例えば、0.1ppb以上、0.5ppb以上、1ppb以上、10ppb以上、100ppb以上、又は1ppm以上であることができる。1-オクテン-3-オンは、体積基準で、例えば、1,000ppm以下、100ppm以下、10ppm以下、又は1ppm以下であることができる。 The tension odor component can contain 1-octen-3-one as a non-sulfur compound in addition to or alone with respect to the sulfur compound. 1-octen-3-one can be, for example, 0.1 ppb or more, 0.5 ppb or more, 1 ppb or more, 10 ppb or more, 100 ppb or more, or 1 ppm or more on a volume basis. 1-octen-3-one can be, for example, 1,000 ppm or less, 100 ppm or less, 10 ppm or less, or 1 ppm or less on a volume basis.
 本開示の消臭剤及び不活性化剤について、以下に例を挙げて説明する。しかしながら、本開示の消臭剤及び不活性化剤は以下の例に限定されるものではない。 The deodorant and deactivator of the present disclosure will be described below with examples. However, the deodorant and the deactivator of the present disclosure are not limited to the following examples.
[実施例1:ジメチルトリスルフィドに対する消臭試験]
 消臭剤0.05質量%とジプロピレングリコール99.95質量%とを混合して、それぞれの消臭剤について消臭剤溶液を作製した。消臭剤溶液1mLと、消臭剤1質量部に対して5×10-4質量部のジメチルトリスルフィドと、を30ミリリットル容量のサンプル管に注入した。専門パネル3人が、サンプル管内の匂いを嗅いで、以下の基準で各消臭剤のジメチルトリスルフィドに対する消臭効果を評価した。
[Example 1: Deodorization test for dimethyl trisulfide]
Deodorant 0.05 mass% and dipropylene glycol 99.95 mass% were mixed and the deodorizer solution was produced about each deodorizer. 1 mL of the deodorant solution and 5 × 10 −4 parts by mass of dimethyl trisulfide with respect to 1 part by mass of the deodorant were injected into a sample tube having a capacity of 30 ml. Three expert panels sniffed the scent in the sample tube and evaluated the deodorizing effect of each deodorant on dimethyltrisulfide according to the following criteria.
[緊張臭原因物質に対する消臭効果]
 2点:専門パネルが、消臭剤の消臭効果が高いと評価した;
 1点:専門パネルが、消臭剤の消臭効果がやや高いと評価した;
 0点:専門パネルが、消臭剤の消臭効果が無いと評価した。
[Deodorizing effect on substances causing tension odor]
2 points: Special panel evaluated that deodorant has high deodorizing effect;
1 point: A special panel evaluated that the deodorant has a slightly higher deodorizing effect;
0 point: The expert panel evaluated that there was no deodorant effect of a deodorizer.
 表1に、試験した消臭剤と、各消臭剤についての専門パネルによる消臭効果の評価を示す。表1に示す評価は、専門パネルの平均点を以下の基準で表記したものである。以下の例において使用した酸化亜鉛の平均粒径は約0.2μmである。 Table 1 shows the deodorant tested and the evaluation of the deodorizing effect of each deodorant by a specialized panel. The evaluation shown in Table 1 represents the average score of the specialized panel according to the following criteria. The average particle size of zinc oxide used in the following examples is about 0.2 μm.
 A:2点;
 B:1.5点以上2点未満;
 C:1点以上1.5点未満;
 D:1点未満。
A: 2 points;
B: 1.5 points or more and less than 2 points;
C: 1 point or more and less than 1.5 point;
D: Less than 1 point.
 試験例1~5の消臭剤には、緊張臭の原因物質であるジメチルトリスルフィドに対する消臭効果が確認された。したがって、試験例1~5の消臭剤は、緊張臭の消臭に有効であると考えられる。 The deodorizers in Test Examples 1 to 5 were confirmed to have a deodorizing effect on dimethyl trisulfide, which is a causative substance of tension odor. Therefore, the deodorizers of Test Examples 1 to 5 are considered to be effective for deodorizing tension odors.
Figure JPOXMLDOC01-appb-T000001
Figure JPOXMLDOC01-appb-T000001
[実施例2:アリルメルカプタンに対する消臭試験]
 消臭剤0.10質量%とジプロピレングリコール99.90質量%とを混合して、それぞれの消臭剤について消臭剤溶液を作製した。消臭剤溶液1mLと、消臭剤1質量部に対して5×10-6質量部のアリルメルカプタンと、を30ミリリットル容量のサンプル管に注入した。専門パネル3人が、サンプル管内の匂いを嗅いで、以下の基準で各消臭剤のアリルメルカプタンに対する消臭効果を評価した。表2に、試験した消臭剤と、各消臭剤についての専門パネルによる消臭効果の評価を示す。評価基準は実施例1と同様である。
[Example 2: Deodorization test for allyl mercaptan]
Deodorizer 0.10 mass% and dipropylene glycol 99.90 mass% were mixed, and the deodorizer solution was produced about each deodorizer. 1 mL of the deodorant solution and 5 × 10 −6 parts by mass of allyl mercaptan with respect to 1 part by mass of the deodorant were injected into a sample tube having a capacity of 30 ml. Three expert panels sniffed the scent in the sample tube, and evaluated the deodorizing effect of each deodorant on allyl mercaptan according to the following criteria. Table 2 shows the deodorant tested, and the evaluation of the deodorizing effect by a specialized panel for each deodorant. The evaluation criteria are the same as in Example 1.
 試験例10~18の消臭剤には、緊張臭の原因物質であるアリルメルカプタンに対する消臭効果が確認された。したがって、試験例10~18の消臭剤は、緊張臭の消臭に有効であると考えられる。 The deodorizers of Test Examples 10 to 18 were confirmed to have a deodorizing effect on allyl mercaptan, which is a causative substance of tension odor. Therefore, the deodorizers of Test Examples 10 to 18 are considered to be effective for deodorizing tension odors.
Figure JPOXMLDOC01-appb-T000002
Figure JPOXMLDOC01-appb-T000002
[実施例3:アリルメルカプタンに対する消臭試験]
 消臭剤0.10質量%とジプロピレングリコール99.90質量%とを混合して、それぞれの消臭剤について消臭剤溶液を作製した。消臭剤は、成分Aとして酸化亜鉛50質量%と、表3に示す成分B50質量%と、を含有する。消臭剤溶液1mLと、消臭剤1質量部に対して2.5×10-6質量部のアリルメルカプタンと、を30ミリリットル容量のサンプル管に注入した。専門パネル3人が、サンプル管内の匂いを嗅いで、以下の基準で各消臭剤のアリルメルカプタンに対する消臭効果を評価した。表3に、試験した消臭剤と、各消臭剤についての専門パネルによる消臭効果の評価を示す。評価基準は実施例1と同様である。
[Example 3: Deodorization test for allyl mercaptan]
Deodorizer 0.10 mass% and dipropylene glycol 99.90 mass% were mixed, and the deodorizer solution was produced about each deodorizer. The deodorizer contains 50% by mass of zinc oxide as component A and 50% by mass of component B shown in Table 3. 1 mL of the deodorant solution and 2.5 × 10 −6 parts by mass of allyl mercaptan with respect to 1 part by mass of the deodorant were injected into a 30-ml sample tube. Three expert panels sniffed the scent in the sample tube, and evaluated the deodorizing effect of each deodorant on allyl mercaptan according to the following criteria. Table 3 shows the deodorant tested, and the evaluation of the deodorizing effect by a specialized panel for each deodorant. The evaluation criteria are the same as in Example 1.
 酸化亜鉛と他の消臭剤とを混合させると、消臭剤成分を単独で用いるよりも総じて消臭効果を高めることができた。例えば、表2に示す試験例10、16、22、23、及び25と、表3に示す試験例26、32、37、38、及び40とをそれぞれ比較すると、実施例2で使用した消臭剤に酸化亜鉛を添加することによって、消臭剤単独よりも消臭効果を高めることができた。例えば、ラポナイト、ヒドロキシプロピル-β-デキストリン、サトウキビエキス、ビワ葉エキス、及び緑茶エキスは単独では消臭効果が低かったが、酸化亜鉛と混合することによって消臭効果を高めることができた。すなわち、これらの消臭成分と酸化亜鉛とには消臭の相乗効果があるものと考えられる。これより、複数の種類の消臭成分の混合は、緊張臭の消臭により有効であると考えられる。特に、第2の消臭成分として酸化亜鉛を含有する消臭剤は、緊張臭の消臭により有効であると考えられる。 When zinc oxide and other deodorant were mixed, the deodorizing effect was generally improved as compared with using the deodorant component alone. For example, comparing Test Examples 10, 16, 22, 23, and 25 shown in Table 2 with Test Examples 26, 32, 37, 38, and 40 shown in Table 3, respectively, the deodorization used in Example 2 By adding zinc oxide to the agent, the deodorizing effect could be enhanced compared to the deodorant alone. For example, laponite, hydroxypropyl-β-dextrin, sugarcane extract, loquat leaf extract, and green tea extract alone had a low deodorizing effect, but the deodorizing effect could be enhanced by mixing with zinc oxide. That is, these deodorizing components and zinc oxide are considered to have a synergistic effect of deodorization. From this, it is thought that mixing of a plurality of types of deodorizing components is more effective for deodorizing tension odors. In particular, a deodorant containing zinc oxide as the second deodorant component is considered to be more effective for deodorizing tension odors.
 試験例12と試験例28とを比較すると、悪臭原因物質に対して酸化亜鉛の量を多くすると、消臭効果を高めることができた。これより、緊張臭に対して消臭剤の適用量を多くすると、消臭効果をより高めることができる。 When comparing Test Example 12 and Test Example 28, the deodorizing effect could be improved by increasing the amount of zinc oxide with respect to the malodor-causing substance. From this, if the application amount of a deodorizer is increased with respect to a tension odor, the deodorizing effect can be improved more.
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
[実施例4:緊張臭モデル組成物に対する消臭試験]
 成分Aとして酸化亜鉛、成分Bとしてヒドロキシプロピル-β-デキストリンを含有する、表4に示す消臭剤を作製した。次に、表5に示す緊張臭成分を含有する緊張臭モデル組成物を作製した。次に、100mLの密閉ガラス容器中で緊張臭モデル組成物100μL及び消臭剤10μLを混合した。そして、密閉ガラス容器を10分間静置した後、密閉ガラス容器の上部空間に存在する気体成分を直接質量分析法により分析した。
[Example 4: Deodorization test for tension odor model composition]
Deodorants shown in Table 4 containing zinc oxide as component A and hydroxypropyl-β-dextrin as component B were prepared. Next, the tension odor model composition containing the tension odor component shown in Table 5 was produced. Next, 100 μL of the tension odor model composition and 10 μL of the deodorant were mixed in a 100 mL sealed glass container. Then, after the sealed glass container was allowed to stand for 10 minutes, the gas components present in the upper space of the sealed glass container were directly analyzed by mass spectrometry.
 その結果、消臭剤と緊張臭モデル組成物とを混合した密閉ガラス容器の上部空間からは、緊張臭成分が検出されなかった。緊張臭成分は、消臭剤に吸着されるなどして上部空間から物理的及び/又は化学的に除去されたものと考えられる。これより、本開示の消臭剤によれば、緊張臭を効果的に消臭できることが確認された。 As a result, no tension odor component was detected from the upper space of the sealed glass container in which the deodorant and the tension odor model composition were mixed. The tension odor component is considered to be physically and / or chemically removed from the upper space by being adsorbed by the deodorant. From this, according to the deodorizer of this indication, it was confirmed that a tension odor can be effectively deodorized.
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000004
Figure JPOXMLDOC01-appb-T000005
Figure JPOXMLDOC01-appb-T000005

[実施例5:心理的・精神的作用試験]
 被験者に緊張臭のモデル組成物を嗅がせて、POMS(登録商標)及びGACLを用いて緊張臭による被験者の心理的・精神的変化を確認した。その結果、被験者は、緊張臭を嗅ぐと覚醒、疲労及び混乱が生じることが確認された。
[Example 5: Psychological / mental effect test]
The subject was sniffed with a tension odor model composition, and the psychological and mental changes of the subject due to the tension odor were confirmed using POMS (registered trademark) and GACL. As a result, it was confirmed that when the subject smells a tense odor, arousal, fatigue and confusion occur.
 次に、緊張臭のモデル組成物と共に、本開示の消臭剤を嗅がせると、被験者に上述のような心理的・精神的変化は見られなかった。これより、本開示の消臭剤は、緊張臭(分泌成分)による心理的・精神的作用を不活性化することができることが確認された。 Next, when the deodorant of the present disclosure was sniffed together with the model composition of the tense odor, the subject did not see the psychological and mental changes described above. From this, it was confirmed that the deodorant of this indication can inactivate the psychological and mental action by a tension odor (secretory component).
 POMS(登録商標)2成人用短縮版(Profile of Mood States Second Edition Adult Short)日本語検査用紙を用いて心理状態変化を分析した試験について以下に詳述する。この心理分析においては、質問の回答に基づいて、ネガティブ気分の指標である「怒り・敵意」、「混乱・当惑」、「抑うつ・落込み」、「疲労・無気力」及び「緊張・不安」、並びにポジティブ気分の指標である「活気・活力」及び「友好」に関する心理状態を確認することができる。検査用紙には各指標について5つの設問があり、各設問に提示された気分ついて各被験者に以下の基準で点数付けしてもらった(各指標につき最高得点20点)。 The following is a detailed description of a test that analyzed psychological state changes using the POMS (registered trademark) 2 adult shortened version (Profile of Mood, States, Second Edition, Adult, and Short) Japanese test paper. In this psychological analysis, based on the answers to the questions, anger / hostility, confusion / embarrassment, depression / depression, fatigue / apathy, and tension / anxiety, which are negative mood indicators, In addition, it is possible to confirm the psychological state related to “liveness / vibration” and “friendship” which are positive mood indexes. There were five questions for each index on the test paper, and each subject was given a score according to the following criteria for the mood presented in each question (maximum score of 20 for each index).
0点:提示された気分がまったくなかった;
1点:提示された気分が少しあった;
2点:提示された気分がまあまああった;
3点:提示された気分がかなりあった;
4点:提示された気分が非常に多くあった。
0 points: no mood presented;
1 point: There was a little feeling presented;
2 points: The mood presented was ok;
3 points: There was a lot of feeling presented;
4 points: The feelings presented were very much.
 まず、8名の被験者を20分間安静状態においた。その後、上記検査用紙の質問に回答してもらった。この検査を「検査1」とする。 First, eight subjects were in a resting state for 20 minutes. After that, I was asked to answer the question on the above inspection sheet. This inspection is referred to as “inspection 1”.
 次に、表6に示す緊張臭モデル組成物のうち、各被験者が認知可能な一番低濃度のモデル組成物を用いて、各被験者に緊張臭を5分間嗅ぎ続けてもらった。その後、検査1と同じ質問に回答してもらった。この検査を「検査2」とする。 Next, among the tension odor model compositions shown in Table 6, each subject continued to sniff the tension odor for 5 minutes using the lowest concentration model composition that each subject could recognize. After that, he asked me to answer the same question as in Exam 1. This inspection is referred to as “inspection 2”.
 検査1及び2における各指標における点数の平均値及び標準偏差を算出した。表7に、結果を示す。図1に、各指標に対する点数の平均値及び標準偏差のグラフを示す。 The average value and standard deviation of the scores for each index in the examinations 1 and 2 were calculated. Table 7 shows the results. In FIG. 1, the graph of the average value of a score with respect to each parameter | index and a standard deviation is shown.
 検査1と検査2の結果を比較すると、図1に示すように、緊張臭を知覚することによって、ネガティブな感情、特に緊張、混乱及び疲労、が高まることが分かった。一方、ポジティブな感情についても、低下する傾向が確認された。これより、緊張臭は、人の感情を不安定な方向に向かわせる心理的・精神的作用を有していることが分かった。 Comparing the results of Test 1 and Test 2, as shown in FIG. 1, it was found that negative emotions, particularly tension, confusion, and fatigue, increase by perceiving a tension odor. On the other hand, there was a tendency for positive emotions to decline. From this, it was found that the tense odor has a psychological and mental action that turns human emotions in an unstable direction.
 上記実施例4において立証したように、本開示の消臭剤は緊張臭成分を除去することができる。したがって、本開示の消臭剤によれば、緊張臭に起因するネガティブな心理的・精神的作用を不活性化(解消、低減、及び/又は緩和)させることができることが分かった。すなわち、本開示の消臭剤は、緊張臭の心理的・精神的作用に対する不活性化剤として適用できることが分かった。 As demonstrated in Example 4 above, the deodorant of the present disclosure can remove the tension odor component. Therefore, according to the deodorant of this indication, it turned out that the negative psychological and mental action resulting from a tension odor can be inactivated (cancellation, reduction, and / or relaxation). That is, it was found that the deodorant of the present disclosure can be applied as an inactivating agent for the psychological and mental effects of a tension odor.
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000006
Figure JPOXMLDOC01-appb-T000007
Figure JPOXMLDOC01-appb-T000007


 本開示の消臭剤及び不活性化剤は、上記実施形態及び実施例に基づいて説明されているが、上記実施形態及び実施例に限定されることなく、本発明の範囲内において、かつ本発明の基本的技術思想に基づいて、各開示要素(請求の範囲、明細書及び図面に記載の要素を含む)に対し種々の変形、変更及び改良を含むことができる。また、本発明の請求の範囲の範囲内において、各開示要素の多様な組み合わせ・置換ないし選択が可能である。 The deodorant and the deactivator of the present disclosure have been described based on the above-described embodiments and examples, but are not limited to the above-described embodiments and examples, and are within the scope of the present invention. Based on the basic technical idea of the invention, various disclosed elements (including elements described in the claims, the specification, and the drawings) can include various modifications, changes, and improvements. In addition, various combinations, substitutions, or selections of the disclosed elements are possible within the scope of the claims of the present invention.
 本発明のさらなる課題、目的及び形態(変更形態含む)は、請求の範囲を含む本発明の全開示事項からも明らかにされる。 Further problems, objects, and forms (including modified forms) of the present invention will become apparent from the entire disclosure of the present invention including the claims.
 本書に記載した数値範囲については、別段の記載のない場合であっても、当該範囲内に含まれる任意の数値ないし範囲が本書に具体的に記載されているものと解釈されるべきである。 The numerical ranges described in this document should be construed as any specific numerical value or range included in the said range, even if not otherwise specified.

Claims (12)

  1.  第1の消臭成分及び第2の消臭成分のうち少なくとも1つを含み、
     前記第1の消臭成分は、銀担持ゼオライト、トコフェロール、酸化亜鉛、カムスナールエキス、ルムプヤンエキス、及びこれらの組合せからなる第1の群から選択される少なくとも1つを含み、
     前記第2の消臭成分は、ラポナイト、銀担持ゼオライト、酸化亜鉛、ニームリーフエキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、トコフェロール、及びこれらの組合せからなる第2の群から選択される少なくとも1つを含む、緊張臭消臭剤。
    Including at least one of a first deodorant component and a second deodorant component;
    The first deodorizing component includes at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Camsnar extract, Lumpuyan extract, and combinations thereof;
    The second deodorant component is composed of laponite, silver-carrying zeolite, zinc oxide, neem leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin, sanna extract, tocopherol, and combinations thereof. The tension odor deodorant containing at least 1 selected from the group of these.
  2.  第1の消臭成分及び第2の消臭成分のうち少なくとも1つを含み、
     前記第1の消臭成分は、銀担持ゼオライト、トコフェロール、酸化亜鉛、カムスナールエキス、ルムプヤンエキス、及びこれらの組合せからなる第1の群から選択される少なくとも1つを含み、
     前記第2の消臭成分は、
     酸化亜鉛と、
     ラポナイト、銀担持ゼオライト、ジブチルヒドロキシトルエン、サトウキビエキス、ビワ葉エキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、緑茶エキス、及びこれらの組合せからなる第3の群から選択される少なくとも1つと、を含む、緊張臭消臭剤。
    Including at least one of a first deodorant component and a second deodorant component;
    The first deodorizing component includes at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Camsnar extract, Lumpuyan extract, and combinations thereof;
    The second deodorant component is
    Zinc oxide,
    Selected from the third group consisting of laponite, silver supported zeolite, dibutylhydroxytoluene, sugarcane extract, loquat leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin, sanna extract, green tea extract, and combinations thereof A tension odor deodorant, comprising:
  3.  前記緊張臭は、緊張状態及び/又は精神的ストレスに起因して体内から発せられる臭いである、請求項1又は2に記載の緊張臭消臭剤。 The tension odor deodorant according to claim 1 or 2, wherein the tension odor is an odor emitted from the body due to a tension state and / or mental stress.
  4.  前記緊張臭の原因物質が、アリルメルカプタン及びジメチルトリスルフィドのうちの少なくとも1つを含む、請求項1~3のいずれか一項に記載の緊張臭消臭剤。 The tension odor deodorant according to any one of claims 1 to 3, wherein the causative substance of the tension odor includes at least one of allyl mercaptan and dimethyl trisulfide.
  5.  前記原因物質が、メチルメルカプタン、ジメチルスルフィド、ジメチルジスルフィド、及びこれらの組合せからなる群から選択される少なくとも1つの化合物をさらに含有する、請求項4に記載の緊張臭消臭剤。 The tension odor deodorant according to claim 4, wherein the causative substance further contains at least one compound selected from the group consisting of methyl mercaptan, dimethyl sulfide, dimethyl disulfide, and combinations thereof.
  6.  前記原因物質が、1-オクテン-3-オンをさらに含む、請求項4又は5に記載の緊張臭消臭剤。 6. The tension odor deodorant according to claim 4 or 5, wherein the causative substance further comprises 1-octen-3-one.
  7.  第1の不活性化成分及び第2の不活性化成分のうち少なくとも1つを含み、
     前記第1の不活性化成分は、銀担持ゼオライト、トコフェロール、酸化亜鉛、カムスナールエキス、ルムプヤンエキス、及びこれらの組合せからなる第1の群から選択される少なくとも1つを含み、
     前記第2の不活性化成分は、ラポナイト、銀担持ゼオライト、酸化亜鉛、ニームリーフエキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、トコフェロール、及びこれらの組合せからなる第2の群から選択される少なくとも1つを含み、
     分泌成分の心理的又は精神的活性作用を不活性化する不活性化剤。
    Including at least one of a first deactivating component and a second deactivating component;
    The first deactivating component includes at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Kamsnar extract, Lumpuyan extract, and combinations thereof;
    The second inactivating component includes laponite, silver-supported zeolite, zinc oxide, neem leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin, sanna extract, tocopherol, and combinations thereof. Comprising at least one selected from the group of two;
    An inactivating agent that inactivates the psychological or mental activity of secretory components.
  8.  第1の不活性化成分及び第2の不活性化成分のうち少なくとも1つを含み、
     前記第1の不活性化成分は、銀担持ゼオライト、トコフェロール、酸化亜鉛、カムスナールエキス、ルムプヤンエキス、及びこれらの組合せからなる第1の群から選択される少なくとも1つであり、
     前記第2の不活性化成分は、
     酸化亜鉛と、
     ラポナイト、銀担持ゼオライト、ジブチルヒドロキシトルエン、サトウキビエキス、ビワ葉エキス、イリス根エキス、シソ葉エキス、ヒドロキシプロピル-β-シクロデキストリン、サンナエキス、緑茶エキス、及びこれらの組合せからなる第3の群から選択される少なくとも1つと、を含み、
     分泌成分の心理的又は精神的活性作用を不活性化する不活性化剤。
    Including at least one of a first deactivating component and a second deactivating component;
    The first deactivating component is at least one selected from the first group consisting of silver-supported zeolite, tocopherol, zinc oxide, Kamsnar extract, Lumpuyan extract, and combinations thereof;
    The second inactivating component is
    Zinc oxide,
    Selected from the third group consisting of laponite, silver supported zeolite, dibutylhydroxytoluene, sugarcane extract, loquat leaf extract, iris root extract, perilla leaf extract, hydroxypropyl-β-cyclodextrin, sanna extract, green tea extract, and combinations thereof At least one of
    An inactivating agent that inactivates the psychological or mental activity of secretory components.
  9.  前記分泌成分は、緊張状態及び/又は精神的ストレスに起因して体内から分泌される成分である、請求項7又は8に記載の不活性化剤。 The inactivating agent according to claim 7 or 8, wherein the secretory component is a component secreted from the body due to tension and / or mental stress.
  10.  前記分泌成分が、アリルメルカプタン及びジメチルトリスルフィドのうちの少なくとも1つを含む、請求項7~9のいずれか一項に記載の不活性化剤。 The inactivating agent according to any one of claims 7 to 9, wherein the secretory component contains at least one of allyl mercaptan and dimethyl trisulfide.
  11.  前記分泌成分が、メチルメルカプタン、ジメチルスルフィド、ジメチルジスルフィド、及びこれらの組合せからなる群から選択される少なくとも1つの化合物をさらに含有する、請求項7~10のいずれか一項に記載の不活性化剤。 The inactivation according to any one of claims 7 to 10, wherein the secretory component further comprises at least one compound selected from the group consisting of methyl mercaptan, dimethyl sulfide, dimethyl disulfide, and combinations thereof. Agent.
  12.  前記分泌成分が、1-オクテン-3-オンをさらに含む、請求項7~11のいずれか一項に記載の不活性化剤。 The inactivating agent according to any one of claims 7 to 11, wherein the secretory component further comprises 1-octen-3-one.
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