WO2019224794A1 - Composition fongicide synergique et son procédé de préparation - Google Patents

Composition fongicide synergique et son procédé de préparation Download PDF

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WO2019224794A1
WO2019224794A1 PCT/IB2019/054332 IB2019054332W WO2019224794A1 WO 2019224794 A1 WO2019224794 A1 WO 2019224794A1 IB 2019054332 W IB2019054332 W IB 2019054332W WO 2019224794 A1 WO2019224794 A1 WO 2019224794A1
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composition
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total mass
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amount
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PCT/IB2019/054332
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Jayprakash Gopalkrishnan RAO
Seema Abhijit PATIL
Jitendra Gajanan PATIL
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Indofil Industries Limited
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Priority to BR112020023106-1A priority Critical patent/BR112020023106A2/pt
Publication of WO2019224794A1 publication Critical patent/WO2019224794A1/fr

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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
    • A01N43/78—1,3-Thiazoles; Hydrogenated 1,3-thiazoles

Definitions

  • the present disclosure relates to a synergistic fungicidal composition and a process for preparation thereof.
  • Enhancement of agricultural products requires protection of the crops and its produce from pest damage.
  • Various chemicals and their formulations have been developed and are currently in use for effective management of fungi.
  • Current methods of agriculture rely heavily on the use of fungicides.
  • fungicidal compositions have been developed to control various fungi.
  • a single fungicide is not useful in all situations.
  • repeated usage of a single fungicide leads to the development of resistance to it and related fungicides. Consequently, research is being conducted to produce fungicides and combinations of fungicides that are safer and easier to use, have better performance, require lower dosages, are not prone to resistance and are cost efficient.
  • Another object of the present disclosure is to provide a synergistic fungicidal composition. Still another object of the present disclosure is to provide a synergistic fungicidal composition having enhanced fungicidal activity and required to be applied in lower dosages.
  • Yet another object of the present disclosure is to provide a synergistic fungicidal composition that is not prone to development of resistance.
  • Yet another object of the present disclosure is to provide a process for preparing a synergistic fungicidal composition.
  • the present disclosure relates to a synergistic fungicidal composition
  • a synergistic fungicidal composition comprising a triazole fungicide, a strobilurin fungicide, an anilide fungicide and agrochemically acceptable excipient.
  • the present disclosure further relates to a process for preparation of a synergistic fungicidal composition.
  • the process comprises admixing predetermined amounts of triazole fungicide, strobilurin fungicide and anilide fungicide to form a mixture of actives.
  • Predetermined quantities of agrochemically acceptable excipients such as diluent, wetting agent, defoamer and antifreeze agent are added to the mixture of actives and mixed at a predetermined mixing speed for a first predetermined time period to obtain a slurry.
  • the slurry is milled to obtain a milled slurry having particulate matter of a predetermined size in the range of 1 to 10 microns.
  • the milled slurry having particulate matter of predetermined size is blended with a defoamer, stabilizer, thickener, dispersing agent and vehicle at a predetermined blending speed for a second predetermined time period to obtain the synergistic fungicidal composition.
  • Embodiments, of the present disclosure will now be described herein. Embodiments are provided so as to thoroughly and fully convey the scope of the present disclosure to the person skilled in the art. Numerous details are set forth, relating to specific components, and methods, to provide a complete understanding of embodiments of the present disclosure. It will be apparent to the person skilled in the art that the details provided in the embodiments should not be construed to limit the scope of the present disclosure. In some embodiments, well-known processes, well-known apparatus structures, and well-known techniques are not described in detail.
  • first, second, third, etc. should not be construed to limit the scope of the present disclosure as the aforementioned terms may be only used to distinguish one element, component, region, layer or section from another component, region, layer or section. Terms such as first, second, third etc., when used herein do not imply a specific sequence or order unless clearly suggested by the present disclosure.
  • the present disclosure provides a synergistic fungicidal composition and a process for preparation thereof.
  • the present disclosure provides a synergistic fungicidal composition wherein, the active ingredients when present in a ratio within a predetermined range exhibit a significant synergistic effect and provide better control and elimination of fungi and/or fungal diseases than an individual fungicide.
  • the synergistic effect of the fungicidal composition of the present disclosure allows the use of reduced doses of fungicides that lowers costs and reduces the adverse effects of fungicides on the ecological environment.
  • the synergistic fungicidal composition of the present disclosure is a combination of three fungicides thereby providing an expanded spectrum of target fungi and/or fungal diseases.
  • the different mechanism of action of each of the three active ingredients used in the fungicidal composition of the present disclosure reduces the development of resistance by fungi.
  • the synergistic fungicidal composition comprises a combination of triazole fungicide, strobilurin fungicide and anilide fungicide in a synergistically effective ratio in the range of 1:1:1 to 75:12.5:1.
  • the synergistic fungicidal composition further comprises one or more agrochemically acceptable excipients.
  • a synergistic fungicidal composition comprising a triazole fungicide, a strobilurin fungicide, an anilide fungicide and agrochemically acceptable excipient.
  • the synergistic fungicidal composition comprises triazole fungicide in an amount in the range of 1% to 75% by weight of the total mass of the composition, strobilurin fungicide in an amount in the range of 1 % to 60% by weight of the total mass of the composition, anilide fungicide in an amount in the range of 1% to 40% by weight of the total mass of the composition and agrochemically acceptable excipient in an amount in the range of 5% to 70% by weight of the total mass of the composition.
  • the triazole fungicide can be selected from the group consisting of azaconazole, bromuconazole, bitertanol, cyproconazole, diclobutrazole, difenoconazole, diniconazole, diniconazole-M, epoxiconazole, etaconazole, fluquinconazole, flusilazole, flutriafol, fenbuconazole, hexaconazole, imibenconazole, ipconazole, metconazole, myclobutanil, penconazole, propiconazole, prothioconazole, quinconazole, simeconazole, tebuconazole, tetraconazole, tricyclazole, triticonazole, triadimefon, triadimenol, oxpoconazole and uniconazole.
  • the triazole compound is present in an amount in the range of 1% to 75% by weight of the total mass of the composition, preferably in the range of 10% to 60% by weight of the total mass of the composition.
  • the triazole fungicide is Tricyclazole.
  • Tricyclazole (CAS No. 41814-78-2) is the common name for 5-methyl-l, 2, 4-triazolo [3, 4- b] [1, 3] benzothiazole and is represented as
  • Tricyclazole is a protective commercial systemic fungicide, which is absorbed rapidly by the roots and foliage and is translocated in the xylem and apoplast within the plant. Inside the plant, the apoplast is the space outside the plasma membrane within which material can diffuse freely. Tricyclazole has strong anti-erosion properties. Tricyclazole mainly inhibits spore adhesion; thereby effectively preventing the bacteria invade.
  • the strobilurin fungicide can be selected from the group consisting of azoxystrobin, kresoxim-methyl, coumoxystrobin, enoxastrobin, dimoxystrobin, fenaminostrobin, flufenoxystrobin, mandestrobin, metominostrobin, picoxystrobin, pyraoxystrobin, pyraclostrobin, pyrametostrobin, triclopyricarb, pyribencarb, fluoxastrobin, oryzastrobin and trifloxystrobin.
  • the strobilurin fungicide is present in an amount in the range of 1 % to 60% by weight of the total mass of the composition, preferably in the range of 10% to 50% by weight of the total mass of the composition.
  • the strobilurin fungicide is Picoxystrobin or Azoxystrobin.
  • the strobilurin fungicide is Picoxystrobin.
  • Picoxystrobin [CAS NO. 117428-22-5] is the common name for Methyl (E) -3-methoxy-2- [2- [6- (trifluoromethyl) -2-pyridyloxymethyl] phenyl ⁇ acrylate and possesses the following structure
  • Picoxystrobin is fungicide belonging to the strobilurin group of chemicals. It is a preventative and curative fungicide with systemic and translaminar movement, acting by inhibition of mitochondrial respiration by blocking the electron transfer at the Qo center of cytochrome Bel. Picoxystrobin demonstrates outstanding breadth of spectrum in cereals, being highly active against Septoria diseases of wheat, Helminthosporium diseases on wheat, barley and oats, Rhynchosporium diseases on barley and rye, Ramularia diseases on barley, Puccinia rust diseases and strobilurin-sensitive powdery mildews on wheat, barley, oats and rye. Its broad spectrum of activity means that the green leaf area of the crop is maintained during the important grain filling period.
  • the anilide or thiazole fungicide can be selected from the group consisting of benalaxy, benalaxyl-M, bixafen, boscalid, carboxin, fenhexamid, fluxapyroxad, isotianil, metalaxyl, metalaxyl-M, metsulfovax, ofurace, oxadixyl, oxycarboxin, penflufen, pyracarbolid, pyraziflumid, sedaxane, thifluzamide, tiadinil, and vangard.
  • the anilide compound is present in an amount in the range of 1% to 40% by weight of the total mass of the composition, preferably in the range of 5% to 35% by weight of the total mass of the composition.
  • the anilide fungicide is Thifluzamide.
  • Thifluzamide (CAS No. 130000-4-07) is the common name for 2', 6'-dibromo-2-methyl-4'- trifluoromethoxy-4-trifluoromethyl-l, 3-thiazole-5-carboxanilide and is represented as
  • Thifluzamide is a commercial fungicide, when applied as a foliar spray or a soil drench, is rapidly absorbed by roots and leaves and is translocated in the xylem and apoplast throughout the plant. Thiazole carboxamide fungicides exhibit the strong suction conductivity and split long residual effect.
  • the synergistic fungicidal composition comprises Tricyclazole, Picoxystrobin, Thifluzamide and agrochemically acceptable excipient.
  • the synergistic fungicidal composition of the present disclosure contains, as essential ingredients, three components that mutually affect each other when used together and display a biological activity that is greater than the sum of the activities when used alone, an effect, which is designated as synergism. It is surprisingly found that the formulation of combination of Tricyclazole, Picoxystrobin or Azoxystrobin and Thifluzamide fungicide results in a synergistic mixture which is remarkably more effective than the individual compounds at the considered doses.
  • the weight ratio of Tricyclazole, Picoxystrobin or Azoxystrobin and Thifluzamide depends on the sensitivity and resistance of the plants, the time of application, the climatic conditions and the soil conditions.
  • the agrochemically acceptable excipients are selected from the group consisting of dispersing agents, defoamers, wetting agents, disintegrating agents, thickener, diluents, binders, preservative, antifreeze agent, filler and adjuvant.
  • the dispersing agent is used for uniformly dispersing the active ingredients in the fungicidal composition.
  • the dispersing agent is selected from the group consisting of sodium lignosulfonate, calcium lignosulfonate, lignin sulphonate, sodium salt of alkyl naphthalene sulfonate, sulfonated aromatic polymer sodium salt, polycarboxylic acid homopolymer, sodium salt of polycarboxylic acid homopolymer, polycarboxylic acid copolymer, Ethylene oxide/Propylene oxide (EO/PO) block copolymers and sodium salt of polycarboxylic acid copolymer.
  • EO/PO Ethylene oxide/Propylene oxide
  • the alkyl group can be a C 1 -C 20 alkyl group and the aromatic group in the sulfonated aromatic polymer is a to C 20 aromatic group.
  • the defoamer can be used to prevent foaming of the composition and is selected from the group consisting of polydimethylsiloxane powder and polydimethylsiloxane liquid.
  • the wetting agent is used to wet the ingredients in the composition with water by lowering their surface tension and is selected from the group consisting of non-ionic surfactant, anionic surfactant and other wetting agents.
  • the non-ionic surfactant is selected from the group consisting of alcohol alkoxylates having moles of ethylene oxide in the range of 9 to 15.
  • the anionic surfactant is selected from the group consisting of alkyl naphthalene sulfonate, dialkyl naphthalene sulfonates, alkyl naphthalene sulfonate condensate, sodium lauryl sulphate and sodium dodecyl benzene sulfonate.
  • the other wetting agents are selected from the group consisting of alkyl ethylene oxide condensates, aryl ethylene oxide condensates, alkyl propylene oxide condensates, aryl propylene oxide condensates, alkylethoxylates, and arylethoxylates.
  • the alkyl group and aryl group in the wetting agent is a -C20 alkyl group.
  • the disintegrating agent helps to disintegrate the substance in water quickly.
  • the disintegrating agent selected from the group consisting of sodium chloride, sodium sulphate, ammonium sulphate, sodium carbonate, sodium bicarbonate and sodium tripolyphosphate.
  • the thickener is selected from the group consisting of xanthan gum, gum arabic, rhamsan gum, locust bean gum, car ageenan, welan gum, starch, carboxymethyl cellulose salt, sodium montmorillonite, polyethylene glycol, hexamethylpropylcellulose and bentonites.
  • the filler and/or diluent is selected from the group consisting of starches and their derivatives, sugars and sugar alcohols, silicates, calcium phosphates, calcium sulfate, dextrates, kaolin clay, bentonite clay, attapulgite, diatomaceous earth, magnesium carbonate, polymethacrylates, talc and salts.
  • the binder is used to bind the ingredients in the composition together to give it the desired strength and is selected from the group consisting of polyvinyl alcohol, polyvinyl-pyrrolidone or vinyl caprolactam either optionally substituted on the ring or in the vinyl group with lower alkyl (Cl to C4 alkyl) or a mixture of these homopolymers and polyacrylamides.
  • the preservative can be added to stabilize the compositions against attack by microorganisms.
  • the preservative is isothiazolone.
  • the antifreeze agent is selected from the group consisting of ethylene glycol, propylene glycol, glycerol, diethylene glycol, triethylene glycol and polyethylene glycol.
  • the adjuvant is selected from the group consisting of amine alkoxylates, polyoxyalkylene triglycerides, alkylpolyglycosides, alkenyl succinic anhydride derivatives, polyvinylpyrrolidones and perfluoroalkyl acids derivatives.
  • Water is used as a diluent to dilute the active ingredients to a desired concentration.
  • the water used is purified water and is selected from deionized water and distilled water.
  • composition will depend upon the type of composition and/or the manner in which the composition is to be applied by the end user.
  • the synergistic fungicidal composition comprises a triazole fungicide in an amount in the range of 1% to 75% by weight of the total mass of the composition, a strobilurin fungicide in an amount in the range of 1 % to 60% by weight of the total mass of the composition, an anilide fungicide in an amount in the range of 1 % to 40% by weight of the total mass of the composition and agrochemically acceptable excipient selected from the group consisting of dispersing agents, defoamers, wetting agents, disintegrating agents, thickener, diluents, binders, preservative, antifreeze agent, filler and adjuvant in an amount in the range of 5% to 70% by weight of the total mass of the composition.
  • the synergistic fungicidal composition comprises a triazole fungicide in an amount in the range of 1% to 75% by weight of the total mass of the composition, a strobilurin fungicide in an amount in the range of 1 % to 60% by weight of the total mass of the composition, an anilide fungicide in an amount in the range of 1 % to 40% by weight of the total mass of the composition and agrochemically acceptable excipient comprising at least one diluent in an amount in the range of 10% to 70% by weight of the total mass of the composition, at least one dispersing agent in an amount in the range of 1% to 20% by weight of the total mass of the composition, at least one defoamer in an amount in the range of 0.01% to 2% by weight of the total mass of the composition, an antifreeze agent in an amount in the range of 1% to 15% by weight of the total mass of the composition, at least one preservative in an amount in the range of 0.00
  • the synergistic fungicidal composition comprises Tricyclazole in an amount in the range of 1 % to 75% by weight of the total mass of the composition, Picoxystrobin in an amount in the range of 1 % to 60% by weight of the total mass of the composition, Thifluzamide in an amount in the range of 1% to 40% by weight of the total mass of the composition and agrochemically acceptable excipient in an amount in the range of 5% to 70% by weight of the total mass of the composition.
  • a lower dose of the synergistic fungicidal composition may offer adequate protection, whereas, certain climatic conditions, resistance offered by the fungi or nature of the target phytopathogenic fungi may necessitate application of higher doses of the synergistic fungicidal composition.
  • the optimum dose usually depends on several factors, for example on the type of phytopathogenic fungi to be treated, on the type or level of development of the infested plant, on the density of vegetation or alternatively on the method of application of the fungicidal composition.
  • the synergistic fungicidal composition can be formulated in a dosage form selected from the group consisting of suspension concentrate, wettable powder, water dispersible granules, granules, dusts, water in oil emulsion, oil dispersion, Zeon® Concentrate formulation, emulsifiable concentrate, suspoemulsion, capsule suspension and tank-mix.
  • Zeon technology refers to the encapsulation of the active ingredient in very small capsules with thin walls. This enables quick“knock-down” of the insects coupled with long-term persistence.
  • the synergistic fungicidal composition is formulated as suspension concentrate, wettable powder and water dispersible granules.
  • compositions can be of any type known in the art that is suitable for application onto all types of cultures or crops. These compositions, which can be prepared in any manner known by a person skilled in the art, also form part of the invention.
  • the synergistic fungicidal composition of the present disclosure may be packaged and sold as a pre-mix composition or as a fungicidal kit comprising individual active ingredients to be combined at the time of application.
  • the synergistic fungicidal composition may be used for foliar application, ground application or application to plant propagation materials.
  • a process for preparation of a synergistic fungicidal composition comprises admixing predetermined amounts of triazole fungicide, strobilurin fungicide and anilide fungicide to form a mixture of actives.
  • Predetermined quantities of agrochemically acceptable excipients such as diluent, wetting agent, defoamer and antifreeze agent are added to the mixture of actives and mixed at a predetermined mixing speed for a first predetermined period of time to obtain a slurry.
  • the slurry is milled to obtain a milled slurry having particulate matter of a predetermined size in the range of 1 to 10 microns.
  • the milled slurry having particulate matter of a predetermined size is blended with a defoamer, stabilizer, thickener, dispersing agent and vehicle at a predetermined blending speed for a second predetermined period of time to obtain the synergistic fungicidal composition.
  • the process for preparation of the synergistic fungicidal composition comprises preparing a mixture of actives by admixing non pre -pulverized Tricyclazole, non-pre -pulverized Picoxystrobin and non-pre -pulverized Thifluzamide, adding to the mixture of actives at least one vehicle, at least one wetting agent, at least one defoamer and at least one antifreeze agent and mixing at a predetermined mixing speed for a first predetermined time period to obtain a slurry, milling the slurry to obtain a milled slurry containing particulate matter of a size in a predetermined range and blending the milled slurry with at least one defoamer, at least one stabilizer, at least one thickener, at least one dispersing agent and at least one vehicle at a predetermined blending speed for a second predetermined time period to obtain a suspension concentrate.
  • the mixing/blending speed is in the range of 2500 rpm to 3500 rpm.
  • the first predetermined time period is in the range of 30 minutes to 40 minutes.
  • the milled slurry contains particulate matter in a size in the range of 1 micron to 10 microns.
  • the second predetermined time period is in the range of 90 minutes to 110 minutes.
  • Suspension concentrates in accordance with the present disclosure are usually produced so as to obtain a stable, non-sedimenting flowable product.
  • the suspension concentrates in accordance with the present disclosure allow the inclusion of high loadings of one or more adjuvant in a one-pack formulation with a fungicide and, therefore, offer the advantage of an optimized and easy-to-use formulation of the crop protection active compound.
  • the separate addition of an adjuvant by the end-user before application has therefore become unnecessary.
  • the process for preparation of a synergistic fungicidal composition comprises pulverizing, separately, predetermined quantities of Tricyclazole, Picoxystrobin and Thifluzamide to obtain a substantially homogenized powder of each, blending predetermined quantities of each of the substantially homogenized powders with a wetting agent, a dispersing agent, a disintegrating agent, a filler and a defoamer to obtain a substantially homogenized mixture, adding a predetermined quantity of water to a predetermined quantity of the substantially homogenized mixture and kneading to obtain a dough, extruding the dough to obtain wet extruded granules, drying the wet extruded granules under controlled drying conditions and at a temperature within a predetermined range to obtain dried extruded granules and sieving the dried extruded granules to obtain granules having granule size within a predetermined range.
  • the synergistic fungicidal composition can be formulated as wettable powder and/or water dispersible granules.
  • the particle size of the substantially homogenized powder is in the rage of 2 pm to 5 pm.
  • the wet extruded granules are dried at a temperature in the range of 35°C to 65°C.
  • the dried extruded granules are sieved to obtained granules having granule size in the range of 0.5 mm to 2.5 mm.
  • the process for preparation of a synergistic fungicidal composition comprises blending predetermined quantities of Thifluzamide, Picoxystrobin and Tricyclazole, a wetting agent, a dispersing agent, a disintegrating agent, a filler and a defoamer to obtain a first substantially homogenized mixture, pounding the first substantially homogenized mixture to obtain a second substantially homogenized mixture having a predetermined particle size, adding a predetermined quantity of water to a predetermined quantity of the second substantially homogenized mixture and kneading to obtain a dough, extruding the dough to obtain wet extruded granules, drying the wet extruded granules under controlled drying conditions and at a temperature within a predetermined range to obtain dried extruded granules and sieving the dried extruded granules to obtain granules having granule size within a predetermined range.
  • a method of controlling and eliminating fungal diseases from plants comprises applying to the soil, a locus of infection, a plant and/or propagation material thereof susceptible to attack by fungi, an effective amount of the synergistic fungicidal composition of the present disclosure.
  • the synergistic fungicidal composition of the present disclosure can be applied either before or after the plants or propagation material thereof is infected by fungi. It may be applied to the soil before emergence of the plants, either pre -planting or post-planting or as a foliar spray at different stages of crop development, with one or more applications early or late post-emergence.
  • the fungicidal composition of the present disclosure has enhanced fungicidal activity and combats resistance shown by the fungi.
  • the synergistic fungicidal composition may be used to control diseases in agricultural lands for cultivating plants without any phytotoxic effect on the plants.
  • the milling was continued till particle size of 1 to 3 micron was obtained.
  • Particle size was analyzed by Malvern particle size analyzer.
  • the finely milled slurry was pumped to mix blend tank where 5g of Defoamer, 3g of preservative, lOg of alcohol ethoxylate and l50g of thickener solution and 19.9g of water were added.
  • the mixture in the mix blend tank was operated at 3000 rpm for 100 minutes to obtain homogeneous slurry of the fungicidal composition.
  • the milling was continued till particle size of 1 to 3 micron was obtained.
  • Particle size was analyzed by Malvern particle size analyzer.
  • the finely milled slurry was pumped to mix blend tank where 5g of Defoamer, 3g of preservative, lOg of alcohol ethoxylate and l50g of thickener solution and 17.7g of water were added.
  • the mixture in the mix blend tank was operated at 3000 rpm for 100 minutes to obtain homogeneous slurry of the fungicidal composition.
  • the structure agent / xanthan gum can be added to the un-milled suspension and milled together with the active ingredient.
  • Example 4 Tricvclazole 35% + Picoxystrobin 15% + Thifluzamide 12% WG: 374g Tricyclazole technical, 162.5g Picoxystrobin technical, l30.2g Thifluzamide technical, 20g sodium lauryl sulphate, 60g naphthalenesulfonic acid-formaldehyde- polycondensate, 50g kraft lignin sulphonate, lOOg ammonium sulphate, 20g film forming agent, 68.3g filler and l5g defoamer were blended in the ribbon blender for 2 hours to obtain substantially homogenized mixture A. Mixture A was ground in the Jet Mill to obtain a Wettable Powder, having particle size in the range of 2 to 9 pm.
  • the wettable powder was charged into a dough maker by adding 180g of water and blended to obtain a dough.
  • the dough was extruded using a basket extruder to obtain granules having granule size in the range of 0.8 mm to 1.5 mm, which was further dried in fluid bed dryer at 45 °C to obtain granules.
  • Pulverized Thifluzamide, Picoxystrobin and tricyclazole were admixed along with lOg sodium lauryl sulphate, 30g naphthalenesulfonic acid-formaldehyde-poly condensate, l5g Kraft lignin sulphonate, 50g precipitated silica, 227.3g filler and lg defoamer in a ribbon blender and blended for 2 hours at 20 rpm to obtain homogeneous wettable powder formulation.
  • synergistic fungicidal compositions as formulated in Examples 1 to 3 were characterized to determine their storage stability.
  • the suspension concentrates were characterized for parameters such as active content and suspensibility. The parameters were determined at room temperature (RT) and at accelerated storage stability study (54 ⁇ 2°C for 14 days.) Table 1: Storage stability of the synergistic fungicidal in accordance with the present disclosure
  • the synergistic fungicidal composition as formulated in Example 4 was characterized to 10 determine the active content and the suspensibility.
  • the water dispersible granule was characterized for parameters such as active content and suspensibility. The parameters were determined before and after aging at 54 ⁇ 2°C for 14 days.
  • the synergistic fungicidal composition as formulated in Example 5 is characterized for active content, suspensibility and wetting time
  • the wettable powder was characterized for parameters such as active content, suspensibility and wetting time. The parameters were determined before and after aging at 54 ⁇ 2°C for 14 days.
  • wettable powder does not show a significant change in active content, suspensibility and wetting time after a period of 14 days.
  • Fungicidal compositions as formulated in Examples 1 to 3 were tested with two way possible tank mix combinations i.e., Tricyclazole 75% WP + Picoxystrobin (Tank Mix), Thifluzamide 24% SC + Picoxystrobin 22.72% SC (Tank Mix) & Tricyclazole 75% WP + Thifluzamide 24% SC (Tank mix) along with solo individual fungicides i.e., Picoxystrobin 22.72% SC, Tricyclazole 75% WP & Thifluzamide 24% SC and Untreated Control against Sheath Blight, Blast and Brown spot of Paddy.
  • the fungicides were applied as foliar spray with Knapsack Sprayer fitted with hollow cone nozzle. Application was initiated with initiation of disease in the field. The sprayings were done at 15 days interval.
  • PDI Percent disease index
  • the disease control DC (%) was calculated by the following formula.
  • Figures in parenthesis are arcsine transformed values. PDI- Percent Disease Incidence; PDC- Percent Disease Control; DAA- Days After Application; NS- Non significant
  • Figures in parenthesis are arcsine transformed values; PDI- Percent Disease Incidence; PDC- Percent Disease Control; DAA- Days After Application; NS- Non significant
  • Figures in parenthesis are arcsine transformed values; PDI- Percent Disease Incidence; PDC- Percent Disease
  • T2 At 15 days after second application, there was no disease progress observed in treatment T2 and recorded cent percent control. The highest disease was recorded in control (6.67%). The significant lowest disease was observed in T2 (0.00%) and Tl (2.00%), T2 was significantly 10 superior over rest of all treatments.
  • the three fungicide ready combinations were sprayed at doses X (1000 ml/ha) and 2X (2000 ml/ha) to check the phytotoxic effects like leaf injury on tips/surface, vein clearing, wilting, necrosis, hyponasty and epinasty on the Paddy crop.
  • the observations on these phytotoxicity parameters were observed on before spray and at 1, 3, 5, 7, 10 and 15 days after application. But there was no any phytotoxicity observed on Paddy crop after spraying in any treatment. Even there was no any adverse effect noticed on Paddy crop in the field applied with fungicides combinations at highest dose of @2000 ml /ha.
  • test fungicides shows synergistic effect for controlling the diseases. Also for prolong the effectiveness of fungicides liable to encounter resistance problems and to limit crop losses, the test fungicides can be used effectively and safely for the management of diseases than solo Tricyclazole 75% WP, Picoxystrobin 22.72% SC and Thifluzamide 24% SC and their two way possible tank mix combinations.
  • the present disclosure described herein above has several technical advantages including, but not limited to, the realization of a synergistic fungicidal composition which has enhanced fungicidal activity and combats resistance shown by fungi.
  • the present disclosure further provides an easy and simple process for the preparation of the synergistic fungicidal composition.
  • first, second, third, etc. should not be construed to limit the scope of the present disclosure as the aforementioned terms may be only used to distinguish one element, component, region, layer or section from another component, region, layer or section. Terms such as first, second, third etc., when used herein do not imply a specific sequence or order unless clearly suggested by the present disclosure.

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  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

La présente invention concerne une composition fongicide synergique comprenant un fongicide à base de triazole, un fongicide à base de strobilurine et un fongicide à base d'anilide. La présente invention concerne également un procédé de préparation d'une composition fongicide synergique. La composition fongicide synergique présente une activité fongicide améliorée et n'est pas sujette au développement d'une résistance par les champignons.
PCT/IB2019/054332 2018-05-24 2019-05-24 Composition fongicide synergique et son procédé de préparation WO2019224794A1 (fr)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114586791A (zh) * 2022-03-10 2022-06-07 青岛恒宁生物科技有限公司 一种含氟唑菌酰胺的杀菌组合物及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009040397A1 (fr) * 2007-09-26 2009-04-02 Basf Se Compositions fongicides ternaires comprenant du boscalide et du chlorothalonil
US20110256238A1 (en) * 2008-12-25 2011-10-20 Sds Biotech K.K. Wood preservative and wood processing method
AU2013201942B2 (en) * 2007-04-25 2013-08-01 Syngenta Participations Ag Fungicidal compositions
US8785662B2 (en) * 2010-05-12 2014-07-22 Sds Biotech K.K. Anilide-based compounds for preserving wood and method of use thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013201942B2 (en) * 2007-04-25 2013-08-01 Syngenta Participations Ag Fungicidal compositions
WO2009040397A1 (fr) * 2007-09-26 2009-04-02 Basf Se Compositions fongicides ternaires comprenant du boscalide et du chlorothalonil
US20110256238A1 (en) * 2008-12-25 2011-10-20 Sds Biotech K.K. Wood preservative and wood processing method
US8785662B2 (en) * 2010-05-12 2014-07-22 Sds Biotech K.K. Anilide-based compounds for preserving wood and method of use thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114586791A (zh) * 2022-03-10 2022-06-07 青岛恒宁生物科技有限公司 一种含氟唑菌酰胺的杀菌组合物及其应用
CN114586791B (zh) * 2022-03-10 2024-03-08 青岛恒宁生物科技有限公司 一种含氟唑菌酰胺的杀菌组合物及其应用

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