WO2019214652A1 - 一种外敷治疗歪嘴面瘫的药物组合物及其制备方法 - Google Patents

一种外敷治疗歪嘴面瘫的药物组合物及其制备方法 Download PDF

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WO2019214652A1
WO2019214652A1 PCT/CN2019/086036 CN2019086036W WO2019214652A1 WO 2019214652 A1 WO2019214652 A1 WO 2019214652A1 CN 2019086036 W CN2019086036 W CN 2019086036W WO 2019214652 A1 WO2019214652 A1 WO 2019214652A1
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grams
sputum
weight
parts
ginger
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PCT/CN2019/086036
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English (en)
French (fr)
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秦兆云
秦西雷
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Qin Zhaoyun
Qin Xilei
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/648—Myriapods, e.g. centipedes or millipedes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238—Saposhnikovia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/47—Euphorbiaceae (Spurge family), e.g. Ricinus (castorbean)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/538—Schizonepeta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies

Definitions

  • the invention relates to a Chinese herbal medicine composition, in particular to an external application for treating a sputum facial sputum pharmaceutical composition and a characteristic preparation application method thereof.
  • the invention of the ancestral 5 generations of traditional Chinese medicine secrets features external application of treatment, from generation to generation, on the basis of inheritance, innovation, addition, improvement, invention, creation, further reduce the treatment time, further improve the efficacy, even if it is cured in advance for the patient Pain is the lifelong task and desire of my Chinese medicine practitioner. Development is the last word.
  • the object of the present invention is to solve the shortcomings of the prior art, and to provide a method for externally treating a pharmaceutical composition of a scorpion scorpion and a characteristic preparation method thereof.
  • S3 implement the application of proportional composition (preferably ointment) to protect the key prescription drugs, 25 grams of ginger, 2 grams of croton, 2.5 grams of cats, 1 gram of silkworm, 0.5 grams of licorice, 2 grams of schizonepeta, 20 grams of ginger, 2.5 grams of croton, 2.5 grams of Nepeta, 3 grams of cats, 1.5 grams of silkworm, 1.5 grams of licorice, 1.5 grams of white aconite, 15 grams of ginger, 3 grams of croton, 2 grams of schizonepeta, 3.5 grams of cat, 1.5 grams of silkworm, 0.5 grams of musk 2 grams, 2 grams of white aconite, 3 grams of white licorice, 30 grams of ginger, 2.5 grams of croton, 1 gram of schizonepeta, 4 grams of cats, 1 gram of silkworm, 1 gram of musk, 1.5 grams of medlar, 1.3 grams of white aconite, licorice 1.5 grams, 1.5 grams of astragalus, 2
  • the medicinal preparation has 2 pieces of roving cloth, 25 cm in length, 20 cm in width, 2 porcelain jars, 1 willow stick, 30 cm in length and thick thumb.
  • Re-paste the paste put it on the spare gauze, make a thickness of about 2 cm, and use it for the medicine (depending on the shape of the face).
  • the patient is lying down or sitting with his head tilted, the plaster is placed on the affected part, and the medicine is attached to the following points as the center, up to the Shangguan point, down to the squat cheek hole, left to the acupoint , right to listen to the point.
  • a patch is attached.
  • the patient holds the medicine stick from the palm of his hand.
  • the left hand is on the left hand and the right hand is on the right side. It does not fall off.
  • the doctor uses the index finger interval 30. The pressure is applied once every minute to make the liquid evenly penetrate into the muscle.
  • the adult application time is 2-3 hours at a time
  • the child applies the first 40 minutes for 1 hour
  • the eyebrow is applied once for 50 minutes to 1 hour
  • the scheduled time is up.
  • External application is a course of treatment (1-15 days) for adults after 8 days.
  • Adolescents will work after 6 days.
  • the application of the treatment of TCM to intermittent counseling or patient feedback feeling, mild burning sensation, pain is a normal phenomenon, some skin after treatment appears light red or deep red, some patients will appear foaming phenomenon, with no The needle is punctured, the venom is infiltrated with sterile paper and cotton balls, and no treatment is needed after treatment.
  • licorice By adding licorice to the formulation of the present invention, it has the supplemental benefit, clearing away heat and detoxification, relieving pain, relieving pain, relieving medicinal properties, acting as an auxiliary material, and the like.
  • the pharmacological properties include anti-inflammatory, anti-oxidation, anti-metamorphic properties, detoxifying ingredients, obvious pain-relieving properties, antibody, resistance, and time-consuming performance, promoting the development of myogenic muscles, and promoting cell regeneration.
  • the experimental comparison further proves that licorice has the effect of making toxic and irritating drugs, alleviating the uniform infiltration and inhaling to reduce the pain, solving the problem of heavy color of the skin of the drug, reducing the treatment time and improving the curative effect.
  • the name of Gancao "Guo Lao" is well-deserved and deserved. It has an indispensable effect in the treatment. It has reduced the patient's burning pain, reduced the skin color of the drug, reduced the healing time, and improved the treatment.
  • the drug can be quickly permeated into the musculoskeletal body in the actual treatment, and has a remarkable effect on the treatment of the disease.
  • the invention provides an external application method for treating a sputum sputum sputum pharmaceutical composition and a characteristic preparation application method thereof, comprising the following steps:
  • S3 implement the application of proportional composition (preferably ointment) to protect the key prescription drugs, 25 grams of ginger, 2 grams of croton, 2.5 grams of cats, 1 gram of silkworm, 0.5 grams of licorice, 2 grams of schizonepeta, 20 grams of ginger, 2.5 grams of croton, 2.5 grams of Nepeta, 3 grams of cats, 1.5 grams of silkworm, 1.5 grams of licorice, 1.5 grams of white aconite, 15 grams of ginger, 3 grams of croton, 2 grams of schizonepeta, 3.5 grams of cat, 1.5 grams of silkworm, 0.5 grams of musk 2 grams, 2 grams of white aconite, 3 grams of white licorice, 30 grams of ginger, 2.5 grams of croton, 1 gram of schizonepeta, 4 grams of cats, 1 gram of silkworm, 1 gram of musk, 1.5 grams of medlar, 1.3 grams of white aconite, licorice 1.5 grams, 1.5 grams of astragalus, 2
  • the medicinal preparation has 2 pieces of roving cloth, 25 cm in length, 20 cm in width, 2 porcelain jars, 1 willow stick, 30 cm in length and thick thumb.
  • Re-paste the paste put it on the spare gauze, make a thickness of about 2 cm, and use it for the medicine (depending on the shape of the face).
  • the patient is lying down or sitting on his head, and the plaster is placed on the affected part.
  • the medicine is attached to the following points as the center, up to the Shangguan point, down to the squat cheek hole, left to the acupoint, Right to listen to the point.
  • a patch is attached.
  • the patient holds the medicine stick from the palm of his hand.
  • the left hand is on the left hand and the right hand is on the right side. It does not fall off.
  • the doctor uses the index finger interval 30. The pressure is applied once every minute to make the liquid evenly penetrate into the muscle.
  • the adult application time is 2-3 hours at a time, the child applies the application for 40 minutes and 1 hour, and the eyebrow is applied once for 50 minutes to 1 hour, and the scheduled time is up. (According to the length of the patient's feedback is very important) External application is a course of treatment (1-15 days) for 8 days after the adult is effective. Adolescents will work after 6 days.
  • Example 1 No licorice was added. According to the March 31, 2016, 31 outpatient clinical records were statistically treated in 17 patients, 9 adult males, 5 females, and 1 male female and 1 female. In a special case, the patient was treated with topical application for 2 to 3 hours. The feedback was hot and the pain was heavier. The child was 40 minutes to 1 hour and 20 minutes. After the external application, the burning pain was light (primary care). After treatment, the skin of the adult has a deep reddish purple appearance, and the foaming is large and more. The children's erosive skin has a deep red color and less foaming, and some of the foaming is small. Specially visit the healing time, adults 8-10 days, children 7-8 days.
  • Example 2 Adding licorice, according to the clinical records of the outpatient clinic on April 1, 2016, 30 days, 22 patients were treated, 11 were adult males, 7 females, 1 male and 1 female, and 1 female (special 1 case)
  • the treatment experiment is carried out under the premise that the drug name is measured at the same time.
  • the adult feedback is hot, the pain is heavier, and the child feedback is less sensitive to the burning sensation.
  • the conscious treatment time is reduced by 10-20 minutes.
  • Adults have a dark red skin, and less foaming, less foaming, no light foaming in children's skin erosion, special return visits to adults 7-8 days, children 6-7 days, statistical comparison
  • the cure rate is increased by 2 to 4 percentage points.

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Abstract

一种外敷治疗歪嘴面瘫的药物组合物及其制备方法，其原料为：鲜生姜、巴豆、荆芥、班猫、蜈蚣、甘草、白附子、西河柳叶、僵蚕、黄芪、麝香、防风；制备方法为：原料用鲜柳棍先后捣碎成半成品，加入备用药粉再捣和制作膏剂，用纱布制做成临床接受药贴待用；或用鲜柳棍先后捣碎成半成品，加入备用药粉，再捣和成膏，阴干碾碎成沫待用，用伤湿止痛膏贴，外敷；亦或再加入常规辅料，浸泡12小时，用纱布滤汁液，收瓷罐内备用，用伤湿止痛膏贴。

Description

[根据细则37.2由ISA制定的发明名称]　一种外敷治疗歪嘴面瘫的药物组合物及其制备方法 技术领域
本发明涉及中草药物组合物，特别是涉及一种外敷治疗歪嘴面瘫药物组合物及其特色制备应用方法。
背景技术
中医学认为人的嘴歪眼斜中风面瘫的病因是面部外受风、寒、邪、毒侵蚀，内部身体虚弱，脉络气血不通，造成的一种五官疑难杂病。病状多为单侧、起病急、歪向健侧，表形肌瘫痪，眼赤间断性流泪液，吃饭塞食流口水，舌头味觉减退，脸部神经麻痹无知觉等等现状。风寒型较多，痉挛型较少，中风型较多，萎缩型面瘫，中风后遗症型较少，上世纪60年代前极少，80年代前较少，90年代至今较多，冬春季较多，夏秋季较少，男性较多，女性较少。由于社会高速发展，生活水平提高，人的饮食，环境污染，目前任何年龄段均有发病。随之患病者病情也顽固复杂化。
据卫生部门信息，在目前国内现有技术中，对歪嘴面瘫病尚无特效的治疗方法，西医未有明显治疗药物。只有用B1、B12、甲钴胺等西药间接调治神经，疗效不明显，中医也没有明显治疗中成药物，只有内服中草汤药，不方便，对胃有刺激，多少有副作用，治疗时间长，疗效慢；针灸电疗、痛苦多。民间尚有用活鳝鱼拉法，口内放血法，面部埋线法等治疗方法，产生不良副作用。
因此发明祖传5代的中医秘技特色外敷治疗法，代代延续至今，在传承基础上创新添加、改进、发明、创造，进一步减少治疗时间，进一 步提高疗效，哪怕是提前一时一分治愈为病人解除痛苦，是我中医的终生任务和愿望。发展才是硬道理。
发明内容
本发明的目的是为了解决现有技术中存在的缺点，而提出的一种外敷治疗歪嘴面瘫药物组合物及其特色制备应用方法。
为了实现上述目的，本发明采用了如下技术方案：
S1,准备原料，鲜生姜15-30重量份、巴豆1.5-4.5重量份、荆芥2-4重量份、班猫2-4.5重量份、蜈蚣0.5-2重量份、白附子1-3重量份、甘草0.5-3重量份、西河柳叶(干)0.5-2.5＝鲜柳棍(拇指粗30厘米长药具两用)。
S2,准备辅料，僵蚕1-2.5重量份，黄芪1.5-3重量份，麝香0.5-1.5重量份，防风1.5-3.5重量份。
S3,实施应用比例组成(优选膏剂)保护关键处方药，生姜25克、巴豆2克、班猫2.5克、僵蚕1克、炙甘草0.5克、荆芥2克、生姜20克、巴豆2.5克、荆芥2.5克、班猫3克、僵蚕1.5克、甘草1.5克、白附子1.5克、生姜15克、巴豆3克、荆芥2克、班猫3.5克、僵蚕1.5克、麝香0.5克、蜈蚣2克、白附子1克、炙甘草、生姜30克、巴豆2.5克、荆芥1克、班猫4克、僵蚕1克、麝香1克、蜈蚣1.5克、白附子1.3、炙甘草1.5克、黄芪1.5克、防风2克。
S4,以上1-4用鲜柳棍先后捣碎成半成品，后加入备用药粉再捣和制作膏剂，用纱布制做成临床接受药贴，待用。
S5,散剂型：生姜70、巴豆9、白附子6、班猫10、僵蚕5、黄 芪10、蜈蚣4、荆芥6、炙甘草3、西河柳叶(干)6用鲜柳棍先后捣碎成半成品，后加入备用药粉，再捣和成膏阴干碾碎成沫，待用，用伤湿止痛膏贴，外敷。制做成分别用量。
S6,擦剂型：生姜120、巴豆13、白附子10、班猫15、僵蚕7、黄芪13、蜈蚣6、麝香3、荆芥5西干河柳叶10、炙甘草4、用鲜柳棍先后捣碎成半成品后加入备用药粉，再加入常规辅料，浸泡12小时，用纱布滤汁液，收瓷罐内备用，用伤湿止痛膏贴等，外用。制做成分别用量。
优选的，所述制作药具粗纱布2块、长25厘米，宽20厘米，瓷罐2个，柳棍1个，长30厘米，拇指粗。先取1罐把生姜用柳棍捣碎成半成品，再取2罐把巴豆用柳棍捣碎成泥状，把1罐内生姜放到2罐内，再把所需中药粉加入到2罐内，重新捣制膏状，放在备用纱布上，制作成厚度为2厘米左右药贴待用(根据脸型而定)采用散剂、擦剂须备用伤湿解痛膏贴及虎骨麝香膏贴等备用。
优选的，患病者立身躺下或坐着头仰偏，膏药贴放在患病部位，药贴以下关穴为中心，上至上关穴，下至地仓颊车穴，左到颧髎穴，右到听会穴。根据病情、眉上攒竹穴、鱼腰处再附加一贴药，患者自用手掌心固定护住药贴，左边用左手，右边用右手，不掉下为度，医者敷贴后用食指间隔30分钟经度施压一次，目的使药液挤出均匀渗入肌肉。
优选的，成年人敷贴时间一次2-3小时间，儿童敷贴二次40分钟1小时，眉上敷贴一次50分钟一1小时，预定时间到即可。(依据 病人反馈时间长短相当重要)外敷贴一次就为一疗程(1-15天)成年人8天后见效。青少年6天后见效。
优选的，敷贴治疗中医者要间断咨询或患者反馈感觉，出现轻度灼热感、疼痛感属正常现象，治疗后有的皮肤出现浅红色或深红色，部分患者会出现发泡现象，用无菌针刺破、毒液用无菌纸、棉球渗去，治疗后不需用任何办法再处理。
与现有技术相比，本发明的有益效果是：
1、通过将本发明配方中添加有甘草，具有补用益气，清热解毒，缓急止痛，缓和药性，作为辅料作用等等。其中药理性能有抗炎、抗氧化、抗变态性能，有解毒成份，有明显解疼性能，有抗体、抗力、抗耗时性能，有促进生肌发育，促进细胞再生性能等等。实验对比进一步证明甘草对有毒刺激性性药物有克制作用，缓和均匀渗透吸入减轻了疼痛感，解决了药蚀皮肤色度重问题，减少治疗时间提高了疗效。甘草"国老"药名不虚传，当之无愧，治疗中有画龙点睛之妙，起到了不可替代的作用，减轻了病人灼热疼痛感，减轻药蚀皮肤色度，减少了治愈时间，治疗更安全提高了疗效。
2、通过将本发明配方中天街有僵蚕，能够在实际的治疗中快速升出面部风寒邪毒，对于病历较长、多种方式治疗过、久治不愈的顽固型患者有较好的治疗效果。
3、通过将本发明配方中天街有僵蚕麝香，能够在实际的治疗中将药物快速的窜透至肌骨中，对治疗病症具有显著的效果盒疗效。
4、治疗歪嘴面瘫病不用内服任何中西药物，不用注射任何针剂不用针灸电疗，专用专治中药贴外敷直达病位，外敷后不要再做任何处理。
5、制作方式方法即古老又现代，古老的是现在用石器、瓷罐、棍棒捣和中药物现配现用，现代是原传承基础上把能粉碎药物事先粉碎成粉末，使药物应用发挥到极限。
6、对患病者患病部位外敷2小时左右，1小时左右掲掉即可，治疗这一次就为一个疗程(1---15天)。
7、对患病者患病部位外敷2小时左右，1小时左右掲掉即可，治疗这一次就为一个疗程(1---15天)。
8、治愈率达97％以上，疗效患病者说了算。疗效是衡量治疗疾病的标准，疗效才是硬标准。
具体实施方式
下面将结合本发明实施例，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。
本发明提出的一种外敷治疗歪嘴面瘫药物组合物及其特色制备应用方法，具有以下步骤：
S1，准备原料，鲜生姜15-30重量份、巴豆1.5-4.5重量份、荆芥2-4重量份、班猫2-4.5重量份、蜈蚣0.5-2重量份、白附子1-3重量份、甘草0.5-3重量份、西河柳叶(干)0.5-2.5＝鲜柳棍(拇指粗30厘米长药具两用)。
S2，准备辅料，僵蚕1-2.5重量份，黄芪1.5-3重量份，麝香0.5-1.5重量份，防风1.5-3.5重量份。
S3，实施应用比例组成(优选膏剂)保护关键处方药，生姜25克、巴豆2克、班猫2.5克、僵蚕1克、炙甘草0.5克、荆芥2克、生姜20克、巴豆2.5克、荆芥2.5克、班猫3克、僵蚕1.5克、甘草1.5克、白附子1.5克、生姜15克、巴豆3克、荆芥2克、班猫3.5克、僵蚕1.5克、麝香0.5克、蜈蚣2克、白附子1克、炙甘草、生姜30克、巴豆2.5克、荆芥1克、班猫4克、僵蚕1克、麝香1克、蜈蚣1.5克、白附子1.3、炙甘草1.5克、黄芪1.5克、防风2克。
S4，以上1-4用鲜柳棍先后捣碎成半成品，后加入备用药粉再捣和制作膏剂，用纱布制做成临床接受药贴，待用。
S5，散剂型：生姜70、巴豆9、白附子6、班猫10、僵蚕5、黄芪10、蜈蚣4、荆芥6、炙甘草3、西河柳叶(干)6用鲜柳棍先后捣碎成半成品，后加入备用药粉，再捣和成膏阴干碾碎成沫，待用，用伤湿止痛膏贴，外敷。制做成分别用量。
S6，擦剂型：生姜120、巴豆13、白附子10、班猫15、僵蚕7、黄芪13、蜈蚣6、麝香3、荆芥5西干河柳叶10、炙甘草4、用鲜柳棍先后捣碎成半成品后加入备用药粉，再加入常规辅料，浸泡12小时，用纱布滤汁液，收瓷罐内备用，用伤湿止痛膏贴等，外用。制做成分别用量。
所述制作药具粗纱布2块、长25厘米，宽20厘米，瓷罐2个， 柳棍1个，长30厘米，拇指粗。先取1罐把生姜用柳棍捣碎成半成品，再取2罐把巴豆用柳棍捣碎成泥状，把1罐内生姜放到2罐内，再把所需中药粉加入到2罐内，重新捣制膏状，放在备用纱布上，制作成厚度为2厘米左右药贴待用(根据脸型而定)采用散剂、擦剂须备用伤湿解痛膏贴及虎骨麝香膏贴等备用。
所述患病者立身躺下或坐着头仰偏，膏药贴放在患病部位，药贴以下关穴为中心，上至上关穴，下至地仓颊车穴，左到颧髎穴，右到听会穴。根据病情、眉上攒竹穴、鱼腰处再附加一贴药，患者自用手掌心固定护住药贴，左边用左手，右边用右手，不掉下为度，医者敷贴后用食指间隔30分钟经度施压一次，目的使药液挤出均匀渗入肌肉。
所述成年人敷贴时间一次2-3小时间，儿童敷贴二次40分钟1小时，眉上敷贴一次50分钟一1小时，预定时间到即可。(依据病人反馈时间长短相当重要)外敷贴一次就为一疗程(1-15天)成年人8天后见效。青少年6天后见效。
所述敷贴治疗中医者要间断咨询或患者反馈感觉，出现轻度灼热感、疼痛感属正常现象，治疗后有的皮肤出现浅红色或深红色，部分患者会出现发泡现象，用无菌针刺破、毒液用无菌纸、棉球渗去，治疗后不需用任何办法再处理。
实施例1：不加甘草，据2016年3月1日...31日，门诊临床记录统计治疗患者17例，成年男性9例，女性5例，儿童男性1例女性1例。特殊病例1例，治疗中成年人外敷2--3小时，反馈灼热感， 疼痛感较重，儿童40分钟一1小时20分钟，外敷后灼热疼痛感轻重(一级护理)。治疗后成年人药蚀皮肤深红紫色表现，而且发泡大，较多，儿童药蚀皮肤深红色表现发泡少，部分泡小。专门回访治愈时间，成年人8--10天，儿童7--8天。
实施例2：添加甘草，据2016年4月1日...30日门诊临床记录统计，治疗患者22例，成年男性11例，女性7例，儿童男性1例，女性1例(特殊1例)在药物名称计量时间相同的前提下治疗实验，治疗中成年人反馈灼热，疼痛感较重，儿童反馈灼热感疼痛感较轻，另外，有意识对个案治疗时间减少10--20分钟治疗后发现成年人药蚀皮肤深红色，而且发泡少，发泡小，儿童药蚀皮肤浅红色现象无有发泡，专门回访治愈时间成年人7--8天，儿童6--7天，统计比较治愈率提高2--4个百分点。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，根据本发明的技术方案及其发明构思加以等同替换或改变，都应涵盖在本发明的保护范围之内。

Claims (5)

  1. 一种外敷治疗歪嘴面瘫药物组合物及其特色制备应用方法，其特征在于，包括以下步骤：
    S1，准备原料，鲜生姜15-30重量份、巴豆1.5-4.5重量份、荆芥2-4重量份、班猫2-4.5重量份、蜈蚣0.5-2重量份、白附子1-3重量份、甘草0.5-3重量份、西河柳叶(干)0.5-2.5＝鲜柳棍(拇指粗30厘米长药具两用)。
    S2，准备辅料，僵蚕1-2.5重量份，黄芪1.5-3重量份，麝香0.5-1.5重量份，防风1.5-3.5重量份。
    S3，实施应用比例组成(优选膏剂)保护关键处方药(四种)：
    1.生姜25克、巴豆2克、班猫2.5克、僵蚕1克、炙甘草0.5克、荆芥2克、
    2.生姜20克、巴豆2.5克、荆芥2.5克、班猫3克、僵蚕1.5克、甘草1.5克、白附子1.5克、
    3.生姜15克、巴豆3克、荆芥2克、班猫3.5克、僵蚕1.5克、麝香0.5克、蜈蚣2克、白附子1克、炙甘草、
    4.生姜30克、巴豆2.5克、荆芥1克、班猫4克、僵蚕1克、麝香1克、蜈蚣1.5克、白附子1.3、炙甘草1.5克、黄芪1.5克、防风2克。
    S4，以上1-4用鲜柳棍先后捣碎成半成品，后加入备用药粉再捣和制作膏剂，用纱布制做成临床接受药贴，待用。
    S5，散剂型：生姜70、巴豆9、白附子6、班猫10、僵蚕5、黄芪10、蜈蚣4、荆芥6、炙甘草3、西河柳叶(干)6用鲜柳棍先后捣碎成半成品，后加入备用药粉，再捣和成膏阴干碾碎成沫，待用，用伤湿止痛膏贴，外敷。制做成分别用量。
    S6，擦剂型：生姜120、巴豆13、白附子10、班猫15、僵蚕7、黄芪13、蜈蚣6、麝香3、荆芥5西干河柳叶10、炙甘草4、用鲜柳棍先后捣碎成半成品后加入备用药粉，再加入常规辅料，浸泡12小时，用纱布滤汁液，收瓷罐内备用，用伤湿止痛膏贴等，外用。制做成分别用量。
  2. 根据权利要求1所述的一种外敷治疗歪嘴面瘫药物组合物及其特色制备应用方法，其特征在于，所述制作药具粗纱布2块、长25厘米，宽20厘米，瓷罐2个，柳棍1个，长30厘米，拇指粗。先取1罐把生姜用柳棍捣碎成半成品，再取2罐把巴豆用柳棍捣碎成泥状，把1罐内生姜放到2罐内，再把所需中药粉加入到2罐内，重新捣制膏状，放在备用纱布上，制作成厚度为2厘米左右药贴待用(根据脸型而定)采用散剂、擦剂须备用伤湿解痛膏贴及虎骨麝香膏贴等备用。
  3. 根据权利要求1所述的一种外敷治疗歪嘴面瘫药物组合物及其特色制备应用方法，其特征在于，患病者立身躺下或坐着头仰偏，膏药贴放在患病部位，药贴以下关穴为中心，上至上关穴，下至地仓颊车穴，左到颧髎穴，右到听会穴。根据病情、眉上攒竹穴、鱼腰处再附加一贴药，患者自用手掌心固定护住药贴，左边用左手，右边用右手，不掉下为度，医者敷贴后用食指间隔30分钟经度施压一次，目的使药液挤出均匀渗入肌肉。
  4. 根据权利要求1所述的一种外敷治疗歪嘴面瘫药物组合物及其特色制备应用方法，其特征在于，成年人敷贴时间一次2-3小时间，儿童敷贴一次40分钟1小时，眉上敷贴一次50分钟一1小时，预定 时间到即可。(依据病人反馈时间长短相当重要)外敷贴一次就为一疗程(1-15天)成年人8天后见效。青少年6天后见效。
  5. 根据权利要求1所述的一种外敷治疗歪嘴面瘫药物组合物及其特色制备应用方法，其特征在于，敷贴治疗中医者要间断咨询或患者反馈感觉，出现轻度灼热感、疼痛感属正常现象，治疗后有的皮肤出现浅红色或深红色，部分患者会出现发泡现象，用无菌针刺破、毒液用无菌纸、棉球渗去，治疗后不需用任何办法再处理。
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