WO2019210888A3 - 抗结核病疫苗及其制备方法和用途 - Google Patents

抗结核病疫苗及其制备方法和用途 Download PDF

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Publication number
WO2019210888A3
WO2019210888A3 PCT/CN2019/094201 CN2019094201W WO2019210888A3 WO 2019210888 A3 WO2019210888 A3 WO 2019210888A3 CN 2019094201 W CN2019094201 W CN 2019094201W WO 2019210888 A3 WO2019210888 A3 WO 2019210888A3
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WIPO (PCT)
Prior art keywords
preparation
method therefor
tuberculosis vaccine
mycobacterium
single cell
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PCT/CN2019/094201
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English (en)
French (fr)
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WO2019210888A2 (zh
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王震玲
魏于全
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成都卫可信生物科技有限公司
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Priority to US17/051,993 priority Critical patent/US11426454B2/en
Publication of WO2019210888A2 publication Critical patent/WO2019210888A2/zh
Publication of WO2019210888A3 publication Critical patent/WO2019210888A3/zh

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4409—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 4, e.g. isoniazid, iproniazid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
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    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
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    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/544—Mucosal route to the airways
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
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  • Nutrition Science (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)

Abstract

提供了一种抗结核病疫苗及其制备方法和用途：先获取分枝杆菌单细胞菌体，再采用射线低剂量、循环辐照所述分枝杆菌单细胞菌体，得到抗结核病疫苗。
PCT/CN2019/094201 2018-05-02 2019-07-01 抗结核病疫苗及其制备方法和用途 WO2019210888A2 (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US17/051,993 US11426454B2 (en) 2018-05-02 2019-07-01 Tuberculosis vaccine, preparation method therefor, and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810410653.5A CN108743931B (zh) 2018-05-02 2018-05-02 抗结核病疫苗及其制备方法和用途
CN201810410653.5 2018-05-02

Publications (2)

Publication Number Publication Date
WO2019210888A2 WO2019210888A2 (zh) 2019-11-07
WO2019210888A3 true WO2019210888A3 (zh) 2019-12-19

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PCT/CN2019/094201 WO2019210888A2 (zh) 2018-05-02 2019-07-01 抗结核病疫苗及其制备方法和用途

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US (1) US11426454B2 (zh)
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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108743931B (zh) * 2018-05-02 2022-08-16 成都威斯克生物医药有限公司 抗结核病疫苗及其制备方法和用途
US20220378902A1 (en) * 2019-08-22 2022-12-01 Sichuan University Bacterial membrane vesicles, and separation and preparation system and method therefor

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1235555A (zh) * 1996-08-29 1999-11-17 吉尼西斯研究及发展有限公司 治疗和诊断分枝杆菌感染的化合物和方法
CN1420784A (zh) * 2001-03-23 2003-05-28 科学与工业研究会 一种治疗结核病和其他细胞内感染疾病的疫苗及其制备方法
EP2144626B1 (en) * 2007-04-12 2014-12-03 Jennifer Lighter Tuberculosis vaccine and method of using same
WO2018006939A1 (en) * 2016-07-05 2018-01-11 Universidad De Zaragoza Inactivated tuberculosis vaccine
CN108743931A (zh) * 2018-05-02 2018-11-06 四川大学 抗结核病疫苗及其制备方法和用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6264952B1 (en) * 1993-11-05 2001-07-24 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Method for protecting a mammalian host against infection by Brucella
CN101721693B (zh) * 2009-12-15 2012-03-14 四川大学 一种改良的重组卡介苗
CN104189898B (zh) * 2014-06-27 2017-09-08 四川大学 铜绿假单胞菌疫苗及其制备方法
CN107802831B (zh) * 2016-09-08 2020-12-01 潍坊华英生物科技有限公司 一种灭活乳酸菌疫苗佐剂

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1235555A (zh) * 1996-08-29 1999-11-17 吉尼西斯研究及发展有限公司 治疗和诊断分枝杆菌感染的化合物和方法
CN1420784A (zh) * 2001-03-23 2003-05-28 科学与工业研究会 一种治疗结核病和其他细胞内感染疾病的疫苗及其制备方法
EP2144626B1 (en) * 2007-04-12 2014-12-03 Jennifer Lighter Tuberculosis vaccine and method of using same
WO2018006939A1 (en) * 2016-07-05 2018-01-11 Universidad De Zaragoza Inactivated tuberculosis vaccine
CN108743931A (zh) * 2018-05-02 2018-11-06 四川大学 抗结核病疫苗及其制备方法和用途

Also Published As

Publication number Publication date
CN108743931B (zh) 2022-08-16
CN108743931A (zh) 2018-11-06
US11426454B2 (en) 2022-08-30
US20210052714A1 (en) 2021-02-25
WO2019210888A2 (zh) 2019-11-07

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