MX2021005026A - Analogos de cannabinoides y metodos para su preparacion. - Google Patents

Analogos de cannabinoides y metodos para su preparacion.

Info

Publication number
MX2021005026A
MX2021005026A MX2021005026A MX2021005026A MX2021005026A MX 2021005026 A MX2021005026 A MX 2021005026A MX 2021005026 A MX2021005026 A MX 2021005026A MX 2021005026 A MX2021005026 A MX 2021005026A MX 2021005026 A MX2021005026 A MX 2021005026A
Authority
MX
Mexico
Prior art keywords
cannabinoid analogs
preparation
methods
analogs
cannabinoid
Prior art date
Application number
MX2021005026A
Other languages
English (en)
Inventor
Philip J Barr
Charles K Marlowe
Jianping Sun
James T Kealey
Original Assignee
Baymedica Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baymedica Inc filed Critical Baymedica Inc
Publication of MX2021005026A publication Critical patent/MX2021005026A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/19—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups having unsaturation outside the aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring monocyclic with no unsaturation outside the aromatic ring
    • C07C39/08—Dihydroxy benzenes; Alkylated derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/24—Halogenated derivatives
    • C07C39/373—Halogenated derivatives with all hydroxy groups on non-condensed rings and with unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01206—3,5,7-Trioxododecanoyl-CoA synthase (2.3.1.206)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01102—Geranyl-pyrophosphate—olivetolic acid geranyltransferase (2.5.1.102)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y404/00—Carbon-sulfur lyases (4.4)
    • C12Y404/01—Carbon-sulfur lyases (4.4.1)
    • C12Y404/01026—Olivetolic acid cyclase (4.4.1.26)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se proporcionan en el presente documento análogos de cannabinoides, incluyendo análogos de cannabinoides halogenados, análogos de cannabinoides hidroxilados, análogos de cannabinoides deuterados y análogos de cannabinoides tritiados. Los análogos de cannabinoides pueden prepararse mediante la expresión parcial o total en células hospederas modificadas, tales como células de levadura modificadas de manera recombinante, opcionalmente en combinación con pasos químicos sintéticos.
MX2021005026A 2018-10-31 2019-10-31 Analogos de cannabinoides y metodos para su preparacion. MX2021005026A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862753708P 2018-10-31 2018-10-31
US201862767447P 2018-11-14 2018-11-14
PCT/US2019/059237 WO2020092823A1 (en) 2018-10-31 2019-10-31 Cannabinoid analogs and methods for their preparation

Publications (1)

Publication Number Publication Date
MX2021005026A true MX2021005026A (es) 2021-07-21

Family

ID=70463287

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021005026A MX2021005026A (es) 2018-10-31 2019-10-31 Analogos de cannabinoides y metodos para su preparacion.

Country Status (10)

Country Link
US (1) US20210403408A1 (es)
EP (1) EP3873451A4 (es)
JP (1) JP2022513411A (es)
CN (1) CN113226297A (es)
AU (1) AU2019371379A1 (es)
BR (1) BR112021008520A2 (es)
CA (1) CA3117714A1 (es)
IL (1) IL282822A (es)
MX (1) MX2021005026A (es)
WO (1) WO2020092823A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020160284A1 (en) 2019-01-30 2020-08-06 Genomatica, Inc. Recovery, decarboxylation, and purification of cannabinoids from engineered cell cultures
WO2020176547A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
US20220315969A1 (en) * 2019-06-06 2022-10-06 Genomatica Inc. Olivetolic acid cyclase variants and methods for their use
CA3132439A1 (en) 2020-05-12 2021-11-12 Canopy Growth Corporation Methods of synthesizing cannabigergol, cannabigerolic acid, and analogs thereof
EP4232017A4 (en) * 2020-10-21 2024-09-04 Inmed Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR TREATING NEURONAL DISORDERS USING CANNABINOIDS
WO2022159506A1 (en) * 2021-01-19 2022-07-28 Merit Therapeutics, Inc. Deuterated cannabidiol compounds
WO2022192582A1 (en) * 2021-03-10 2022-09-15 Treehouse Biosciences, Inc. Methods of synthesizing halogenated cannabinoids and derivatives of cannabinoids
WO2022213120A1 (en) * 2021-04-02 2022-10-06 Lygos, Inc. Cannabinoids from substituted resorcinol carboxylic acids
CN116648241A (zh) * 2021-04-14 2023-08-25 成都百裕制药股份有限公司 氘代苯酚衍生物及其制备方法和用途
WO2022251714A2 (en) * 2021-05-27 2022-12-01 Cb Therapeutics, Inc. Olivetolic acid cyclases for cannabinoid biosynthesis
CN115504862B (zh) * 2021-06-07 2024-07-05 南通新世元生物科技有限公司 一种大麻萜酚的制备方法
CN113846125B (zh) * 2021-09-06 2024-01-30 云南省烟草农业科学研究院 枯草芽孢杆菌、红发夫酵母和根霉混合烟草发酵方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003214226A1 (en) * 2002-03-18 2003-10-08 Immugen Pharmaceuticals, Inc. Topical formulations of resorcinols and cannibinoids and methods of use
US8481085B2 (en) * 2006-06-15 2013-07-09 Gw Pharma Limited Pharmaceutical compositions comprising cannabigerol
WO2014177593A1 (en) * 2013-04-29 2014-11-06 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Amorfrutin analogs as ppargamma-modulators
AU2015308136B2 (en) * 2014-08-25 2020-07-09 Teewinot Technologies Limited Apparatus and methods for the simultaneous production of cannabinoid compounds
GB2542797A (en) * 2015-09-29 2017-04-05 Gw Pharma Ltd Use of cannabinoids in the treatment of inflammatory skin diseases
WO2018057385A2 (en) * 2016-09-20 2018-03-29 22Nd Century Limited, Llc Trichome specific promoters for the manipulation of cannabinoids and other compounds in glandular trichomes
US11312979B2 (en) * 2017-02-17 2022-04-26 Hyasynth Biologicals Inc. Method and cell line for production of phytocannabinoids and phytocannabinoid analogues in yeast

Also Published As

Publication number Publication date
CA3117714A1 (en) 2020-05-07
IL282822A (en) 2021-06-30
BR112021008520A2 (pt) 2021-08-03
AU2019371379A1 (en) 2021-05-27
WO2020092823A1 (en) 2020-05-07
EP3873451A1 (en) 2021-09-08
CN113226297A (zh) 2021-08-06
JP2022513411A (ja) 2022-02-07
EP3873451A4 (en) 2022-08-10
US20210403408A1 (en) 2021-12-30

Similar Documents

Publication Publication Date Title
MX2021005026A (es) Analogos de cannabinoides y metodos para su preparacion.
WO2018109174A3 (en) Il-11 antibodies
WO2018109170A3 (en) Il-11ra antibodies
MX2021014712A (es) Polipeptidos de transposasa y sus usos.
MY191035A (en) Affinity-oligonucleotide conjugates and uses thereof
SG10201803042PA (en) Anti-tim-3 antibodies
MX2016013512A (es) Sistemas y metodos para el uso simultaneo del espectro dentro del espectro usado activamente.
SA518390949B1 (ar) طريقة لتحديد المسامية المرتبطة بمادة عضوية في بئر أو تكوين
EP3763214A3 (en) Endophytes, associated compositions, and methods of use thereof
BR112017016897A2 (pt) cepas fúngicas e métodos de uso
SG10201808259TA (en) Anti-jagged1 antibodies and methods of use
MX2021003654A (es) Metodo para seleccionar neoepitopes.
WO2016196912A8 (en) Methods to induce conversion of regulatory t cells into effector t cells for cancer immunotherapy
BR112019008385A2 (pt) método de preparação de células de levedura eletrocompetentes e métodos de uso das referidas células
BR112018069506A2 (pt) métodos para transfectar plantas e para reduzir eventos de integração aleatória
CA186762S (en) Tire
CA186761S (en) Tire
WO2016101960A3 (en) Yeast for preparing alcoholic beverages
PH12020550217A1 (en) Nutrient-spore formulations and uses thereof
ZA202101477B (en) Nucleic acid isolation and related methods
EP3672724A4 (en) ELECTRIC CATALYSTS, THEIR PRODUCTION AND USE FOR FUEL CELLS
PL3344763T3 (pl) Szczepy drożdży z koekspresją egzogennych glukoamylaz, sposób otrzymywania tych szczepów drożdży i ich zastosowanie do wytwarzania bioetanolu
WO2013188147A3 (en) Email content sharing
PH12015501335A1 (en) Immunogenic composition comprising mycoplasma antigens
EP3889219A4 (en) POLYCARBONATE COMPOSITION, METHOD FOR PREPARATION AND USE THEREOF