WO2019206278A1 - 一种用于检测的反应容器 - Google Patents

一种用于检测的反应容器 Download PDF

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Publication number
WO2019206278A1
WO2019206278A1 PCT/CN2019/084554 CN2019084554W WO2019206278A1 WO 2019206278 A1 WO2019206278 A1 WO 2019206278A1 CN 2019084554 W CN2019084554 W CN 2019084554W WO 2019206278 A1 WO2019206278 A1 WO 2019206278A1
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WO
WIPO (PCT)
Prior art keywords
cavity
reaction
reagent
cover
container
Prior art date
Application number
PCT/CN2019/084554
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English (en)
French (fr)
Inventor
罗进才
叶长钦
Original Assignee
东莞德益生物医疗科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CN201820638336.4U external-priority patent/CN208297330U/zh
Priority claimed from CN201810404762.6A external-priority patent/CN108489904A/zh
Application filed by 东莞德益生物医疗科技有限公司 filed Critical 东莞德益生物医疗科技有限公司
Priority to EP19792062.2A priority Critical patent/EP3789752B1/en
Priority to US17/051,153 priority patent/US20210181088A1/en
Publication of WO2019206278A1 publication Critical patent/WO2019206278A1/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/042—Caps; Plugs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/044—Connecting closures to device or container pierceable, e.g. films, membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0325—Cells for testing reactions, e.g. containing reagents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0378—Shapes

Definitions

  • the invention relates to the field of analytical detection technology, and in particular to a reaction vessel for detection.
  • an automatic biochemical analyzer which automatically or partially completes the steps of adding, adding reagents, mixing, pre-warming, colorimetric (turbidity), calculation of results and reporting in biochemical immunoassay. Work efficiency and quality of inspection are greatly improved.
  • the existing automatic biochemical analyzer is bulky, expensive, complicated in operation, and requires professional equipment for sample pretreatment. Therefore, it can only be applied to a central laboratory of a large hospital and operated by trained professionals. None of the above methods can meet the needs of on-site rapid detection.
  • microfluidic technology In the field of rapid detection in the field, microfluidic technology has emerged, which integrates the functions of sampling, reagent, mixing, heat preservation and colorimetry required for biochemical analyzer detection on a microchip, but the technology can only exist once. At the same time, the defects of several indicators are detected, and the single-index indicators cannot be detected for detection, and the current detection results of the technology are poor in accuracy.
  • the object of the present invention is to provide a reaction container for bedside and on-site rapid detection, which is low in cost, reliable in results, simple in operation, quick in reporting, and capable of miniaturizing the instrument.
  • a reaction container for testing includes a reaction cup, a sample holder and a cover, and the sample holder is used for being accommodated in the reaction cup or/and the cover, and the reaction cup is made of a light-transmitting material.
  • the reaction cup is provided with a first cavity for accommodating the first reagent of the outside, and the sample holder is provided with a collecting portion for accommodating the detection sample of the outside, the collecting portion is exposed in the first cavity, and the cover is used for The opening of the first cavity is covered, and the first reagent contained in the first cavity is used to mix the detection sample contained in the collecting portion.
  • the collecting portion is a capillary hole disposed in the sample holder, and the capillary hole communicates with the first cavity, and the capillary hole is used for accommodating the external detecting sample.
  • the collecting portion is a receiving blind groove disposed in the sample holder, and the receiving blind groove is located at a lower end of the sample holder, and the upper end of the sample holder is provided with a liquid passing hole, and the liquid passing hole is used for connecting the receiving blind groove and the first A cavity.
  • the reaction container for detecting further comprises a piercing member and a material package, and the piercing member and the container bag are disposed in the reaction cup or/and in the cover, and the container is provided for receiving a second cavity of the external second reagent and a membrane for covering the opening of the second cavity, the piercing member is configured to pierce the membrane to cause the second reagent to mix the first reagent and the sample.
  • the piercing member and the material package are all installed in the cover, the gap between the piercing member and the container is provided, and the cover is made of a soft material.
  • the piercing member is mounted on the reaction cup, the container is disposed on the cover, and the cover is disposed in the reaction cup.
  • the piercing member has a covering piece and a piercing portion protruding from the covering piece, the covering piece is provided with a through hole penetrating the covering piece, and the piercing part is used for piercing the diaphragm.
  • the cover comprises an outer cap and an inner cap mounted in the outer cap, the outer cap is detachably connected to the reaction cup, and the inner cap is provided with a groove communicating with the first cavity, and the material is contained in the cover Inside the groove.
  • the reaction container for detecting further comprises a sealing ring
  • the outer cap is sleeved on the outer side of the reaction cup
  • the reaction cup is provided with an annular blind groove
  • the annular blind groove is recessed from the outer surface of the reaction cup
  • the sealing ring It is accommodated in the annular blind groove, and the sealing ring protrudes from the outer surface of the reaction cup and is used to resist the inner side wall of the outer cap.
  • the cuvette is provided with a limiting portion protruding into the first cavity, and the sample holder is provided with a supporting portion for contacting the limiting portion, and the supporting portion is clamped between the limiting portion and the cover.
  • the beneficial effects of the invention during the use of the reaction container, when only one reagent is used for the detection, the first reagent prepared in advance is loaded into the first cavity, and the prepared test sample is accommodated in the test sample.
  • the sample holder In the collecting portion, the sample holder is then packaged in the reaction cup or/and the cover, the cover is covered, and then the first reagent contained in the first chamber is mixed with the detection sample contained in the collecting portion;
  • the first reagent prepared in advance is loaded into the first cavity, and the second reagent prepared in advance is loaded into the container, and the prepared sample is prepared in advance.
  • the sample holder is then packaged in the reaction cup or/and the cover, the cover is covered, and then the first reagent contained in the first chamber is mixed with the detection sample contained in the collecting portion. Then, an external force is applied at a desired time to cause the piercing member to puncture the contents, so that the second reagent in the container is mixed with the mixture of the first reagent and the test sample.
  • the reaction vessel has a simple structure and is convenient to use, so that the reagents used for the detection are prepared in advance and released in the required time and order, omitting the steps of adding reagents, washing needles, washing cups, etc., so that the instrument for operating the reaction vessel does not need to be loaded. Needle, reagent needle, liquid path, washing and other devices and steps greatly simplify the structure of the instrument, reduce the size of the instrument, reduce the cost, increase the reliability, and make the operation simpler, which is suitable for rapid detection in the field.
  • Figure 1 is a schematic view of the structure of the present invention
  • Figure 2 is a cross-sectional view of the reaction cup and the sealing ring of the present invention
  • Figure 3 is a cross-sectional view of the sample holder of the present invention.
  • Figure 4 is a cross-sectional view of the container of the present invention.
  • Figure 5 is a cross-sectional view of the piercing member of the present invention.
  • Figure 6 is a cross-sectional view of the closure of the present invention.
  • a reaction container for testing includes a reaction cup 1, a sample holder 2 and a cover 3 for accommodating in the reaction cup 1 or/and
  • the reaction cup 1 has a substantially hollow structure, and the reaction cup 1 is provided with a first cavity 4 for accommodating the first reagent of the outside, and the first cavity 4 is recessed from the end surface of the reaction cup 1.
  • the sample holder 2 is provided with a collecting portion 5 for accommodating the detecting sample of the outside. The collecting portion 5 is exposed in the first cavity 4, and the cover 3 is used to cover the opening of the first cavity 4, and the first cavity 4 is accommodated.
  • the first reagent is used to mix the test sample contained in the collecting portion 5.
  • the reaction vessel when only one reagent is required for the test, the first reagent in a liquid state prepared in advance is loaded into the first chamber 4, and then the cuvette 1 and the cap 3 are mounted together. Separately packaged, and then the first reagent is tightly packed in the first cavity 4; the sample holder 2 is separately packaged; when it is necessary to analyze and detect the test sample, the reaction cup 1 and the cover 3 are disassembled, and the sample for detection is used.
  • the sample device is added to the vacant blind trough of the sample holder 2 or the test sample is quantitatively taken up by the capillary hole 6 of the sample holder 2, and then the sample holder 2 is packaged in the cuvette 1 or/and the cover 3, and then the cuvette is placed 1 is tightly assembled with the cover 3, and then the first reagent contained in the first chamber 4 can be mixed with the test sample contained in the collecting portion 5 by reversing the reaction container at a controlled time point.
  • the first reagent in a liquid state prepared in advance is loaded into the first cavity 4, and the required second reagent is prepared in advance and packaged in the container 8 for the contents.
  • the bag 8 is accommodated in the reaction cup 1 or/and in the cover 3, and then the cuvette 1 and the cover 3 are mounted together and packaged separately, thereby tightly encapsulating the first reagent in the first cavity 4, second
  • the reagent is tightly packed in the material package 8; the sample holder 2 is separately packaged; when it is necessary to analyze and test the test sample, the reaction cup 1 and the cover 3 are disassembled, and then the sample for detection is applied to the sample holder 2 by using a sample loading device.
  • the test sample is quantitatively taken up in the vacant blind groove or by the capillary hole 6 of the sample holder 2, and then the sample holder 2 is packaged in the cuvette 1 or/and the cover 3, and then the cuvette 1 and the cover 3 are tightly assembled.
  • the first reagent contained in the first chamber 4 can be mixed with the test sample contained in the collecting portion 5 by reversing the reaction container at a controlled time point, and then can be controlled. Good time point by pressing the material pack 8 or displacing the inner cap 19 16 that the piercing member to pierce the membrane receiving material 11 of the bag 8, and then the reaction vessel by way of a first reagent reversed, after the detection of the sample mixture was mixed with a second reagent receiving material 8 in the mixing bag.
  • the reaction vessel has a simple structure and is convenient to use. It is not only suitable for single reagent detection, but also for double reagent detection. More importantly, it can prepare the reagents for detection as needed and release them in the required time and sequence, omitting the reagent addition. , washing needles, washing cups and other steps, so that the operating instrument does not need to set up the needle, reagent needle, liquid path, washing and other devices and steps, greatly simplifying the structure of the instrument, making the instrument compact, cost reduction, reliable Increased sex, while making operation easier, suitable for on-site rapid detection.
  • the reaction cup 1 is provided with a limiting portion 121 protruding into the first cavity 4, and the sample holder 2 is provided with a supporting portion 12 for contacting the limiting portion 121.
  • the supporting portion 12 is clamped between the limiting portion 121 and the sealing portion Between the covers 3.
  • the stopper portion 121 blocks the support portion 12 of the sample holder 2, preventing the sample holder 2 from being excessively loaded.
  • the limiting portion 121 is annular, such that the limiting portion 121 can block the sample holder 2 regardless of the angle from which the sample holder 2 is loaded into the cuvette 1.
  • the sample holder 2 further includes a tapered portion 13 connected to the support portion 12, and the collecting portion 5 is connected to one end of the tapered portion 13 away from the support portion 12, the support portion 12, the tapered portion 13 and the collecting portion.
  • 5 is a one-piece construction.
  • the collecting portion 5 is a capillary hole 6 disposed on the sample holder 2, the capillary hole 6 is in communication with the first cavity 4, the capillary hole 6 is for accommodating an external detecting sample, and the upper end of the sample holder 2 is provided with a liquid passing hole 14.
  • the liquid-passing hole 14 extends through the side wall of the sample holder 2. In use, the collecting portion 5 is inserted into the external detecting sample, and the detecting sample can automatically enter the capillary hole 6 under the action of the capillary phenomenon.
  • the reaction vessel is inverted, and the first reagent is brought into contact with the test sample and mixed.
  • the reaction container when the reaction container is upright, the first reagent contained in the first chamber 4 is not in contact with the test sample in the collecting portion 5 of the sample holder 2; when the reaction container is inverted downward, the first chamber 4 is accommodated. The first reagent is placed in contact with the test sample in the collection portion 5 of the sample holder 2.
  • the collecting portion 5 is a receiving blind groove (not shown) disposed on the sample holder 2, the receiving blind groove is located at the lower end of the sample holder 2, and the liquid passing hole 14 extends through the side wall of the sample holder 2
  • the hole 14 is configured to communicate with the receiving blind groove and the first cavity 4, and the first reagent in the first cavity 4 is located below the liquid passing hole 14.
  • the reaction container when the reaction container is upright, the first reagent contained in the first chamber 4 is not in contact with the test sample in the collecting portion 5 of the sample holder 2; when the reaction container is inverted downward, the first chamber 4 is accommodated. The first reagent is placed in contact with the test sample in the collection portion 5 of the sample holder 2.
  • the reaction container for detecting further includes a piercing member 7 and a material bag 8 , and the piercing member 7 and the material bag 8 are disposed in the reaction cup 1 or/ And the cover 3, the container bag 8 is provided with a second cavity 9 for accommodating the second reagent of the outside and a diaphragm 11 for closing the opening of the second cavity 9 of the cover 3, and the piercing member 7 is used for
  • the membrane 11 is pierced such that the mixture of the first reagent and the test sample is mixed with the second reagent such that the test sample can be detected by mixing with the two reagents in sequence.
  • the diaphragm 11 may be a plastic sheet or an aluminum foil sheet or the like according to actual needs.
  • the piercing member 7 and the material bag 8 are all installed in the cover 3, and the piercing member 7 and the container bag 8 have a gap.
  • the cover 3 is made of a soft material.
  • the cover 3 is used. Made of silicone.
  • the piercing member 7 is mounted in the cuvette 1, and the container bag 8 is mounted in the cap 3, and the cap 3 is movably disposed on the cuvette 1.
  • the cover 3 can be screwed onto the cuvette 1.
  • the cover 3 is rotated by the grip cover 3, so that the cover 3 moves relative to the reaction cup 1, and the reaction
  • the bag 8 is moved together until the piercing member 7 pierces the diaphragm 11, and then the second reagent in the bag 8 is released and the first reagent in the first cavity 4 is detected. Sample mix.
  • the cover 3 can also be slidably disposed on the cuvette 1 according to actual needs.
  • the piercing member 7 has a covering piece 15 and a piercing portion 16 protruding from the covering piece 15 .
  • the covering piece 15 is substantially flat, and the piercing portion 16 is self-closing piece. 15 is protruded upward, and the covering piece 15 and the puncturing part 16 are integrally formed.
  • the covering piece 15 is provided with a through hole 17 penetrating through the covering piece 15 , and the covering piece 15 is located between the sample holder 2 and the container bag 8 and pierced
  • the portion 16 is used to pierce the membrane 11 .
  • the piercing member 7 has a tapered shape.
  • the piercing portion 16 may be pyramidal or conical, and the outer diameter of the piercing portion 16 away from the end of the covering sheet 15 is smaller than The puncturing portion 16 is close to the outer diameter of one end of the covering piece 15, ensuring that the puncturing portion 16 can easily puncture the diaphragm 11 of the container bag 8.
  • the puncture portion 16 pierces the membrane 11, the second reagent in the contents of the bag 8 can be released through the perforations 17 to be mixed with the first reagent and the test sample in the first chamber 4.
  • the cover 3 includes an outer cap 18 and an inner cap 19 mounted in the outer cap 18 .
  • the outer cap 18 is detachably connected to the reaction cup 1
  • the inner cap 19 is provided with a groove 21 communicating with the first cavity 4 and a slot 22 communicating with the groove 21, the groove 21 is recessed from the lower surface of the inner cap 19, the groove 21 does not penetrate the inner cap 19, and the card slot 22
  • the side wall of the recess 21 is recessed, and the container 8 is received in the recess 21, and the cartridge 8 is provided with a latch 23 protruding into the slot 22, and the latch 23 is self-contained.
  • the outer surface is protruding.
  • the block 23 protrudes into the card slot 22, and the side wall of the card slot 22 abuts against the outer surface of the block 23 to prevent the contents pack 8 from being removed from the inner cap 19. Falling off.
  • the card slot 22 may not be provided.
  • the interference fit between the container bag 8 and the groove 21 is utilized, and the friction between the outer surface of the container bag 8 and the side wall of the groove 21 will be utilized.
  • the inner bag 19 is fixed in the inner cap 19; preferably, the inner cap 19 is made of an elastic material (such as silica gel). After the container bag 8 is loaded into the recess 21, the inner cap 19 is elastically deformed. The elastic restoring force of the cap 19 secures the contents pack 8 in the inner cap 19.
  • the reaction vessel for testing further includes a sealing ring 24, and the outer cap 18 is sleeved on the outer side of the cuvette 1, for example, the outer cap 18 is screwed to the outer side of the cuvette 1, and the cuvette 1 is provided with an annular blind groove 25
  • the annular blind groove 25 is recessed from the outer surface of the reaction cup 1, and the sealing ring 24 is received in the annular blind groove 25.
  • the sealing ring 24 protrudes from the outer surface of the reaction cup 1 and is used for contacting the inner side wall of the outer cap 18.
  • the seal ring 24 is used to seal the gap between the cover 3 and the cuvette 1 to prevent the reagent or the test sample in the first chamber 4 from leaking through the gap between the cover 3 and the cuvette 1.
  • the sealing ring 24 is made of an elastic material such as silica gel or the like.
  • the reaction cup 1 is made of light-transmissive plastic, translucent quartz and light-transmissive glass, and the solution in the first cavity 4 of the reaction cup 1 is irradiated by the external detection light to detect the inside of the first cavity 4.
  • the solution absorbs the absorbance value of a specific wavelength of light, thereby enabling detection of a specific analyte in the test sample.
  • the volume of the first volume 4 is 0.05-8 ml.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

本发明涉及分析检测技术领域，尤其公开了一种用于检测的反应容器，包括反应杯、样本支架及封盖，样本支架用于容设在反应杯内或/和封盖内，反应杯设有第一容腔，样本支架设有收集部，封盖用于遮盖第一容腔的开口；反应杯内或/和封盖内还可容设容料包和刺破件，容料包设有用于容置外界的第二试剂的第二容腔及用于封盖第二容腔的开口的膜片，刺破件用于刺破膜片以使得第二试剂混合第一试剂及检测样本；本发明可以使检测所用的试剂按需要预先准备并按需要的时间和顺序与检测样本反应，使操作的仪器不需设置加样针、加试剂针、液路、清洗等装置及步骤，实现仪器小型化、操作简便化，适用于床旁快速检测。

Description

一种用于检测的反应容器 技术领域
本发明涉及分析检测技术领域，尤其公开了一种用于检测的反应容器。
背景技术
随着科学技术的不断进步，检测分析设备出现了向两个方向发展的趋势：一种是向着更“高、精、集成”的方向发展，此方向依赖大型全自动的仪器设备，具有批量检测速度快、结果准确等优势，但也存在仪器价格高昂，操作复杂，单个样本报告时间长等缺陷；另一种是向着“简单、便捷、快速”的方向发展，其特点是实现仪器小型化、操作简便、报告快捷，虽然其批处理样本能力不如大型全自动仪器，但其具有仪器成本低，样本处理简单，适应于现场快速检测的需要。
在疾病诊断、环境监测、食品与药品安全等领域，对生化、免疫等检测指标进行现场快速定量检测分析十分重要。在该领域，传统方法采用分光光度计检测，其缺点是操作繁琐、工作效率低下、重复性差、检测参数少，远远不能满足实际工作需要。之后又出现了半自动生化分析仪，其在分光光度计的基础上实现了一定程度的自动化，提高了工作效率，但仍不能满足样本量日常增长的实际工作需要。
目前已发展到全自动生化分析仪，该方法将生化免疫分析中的加样、加试剂、混合、预温、比色(浊)、结果计算与报告等步骤的部分或全部由仪器自动完成，工作效率和检测质量大大提高。但现有全自动生化分析仪体积庞大、价格昂贵、操作复杂、还需要配备专业设备进行样品的前处理，所以只能应用于大型医院的中心实验室，由经过培训的专业人员进行操作。以上方法均不能满足现场快速检测的需要。
在现场快速检测领域，出现了微流控技术，该技术将生化分析仪检测所需 的取样、加试剂、混合、保温、比色等功能整合在一块微型芯片上，但该技术存在只能一次同时检测若干指标的缺陷，不能实现拆分单项指标进行检测，且该技术目前检测结果准确性差等缺陷。
其他的现场快速检测设备则是将全自动生化分析仪小型化，但因仍然存在需设置自动加样、洗针、混合、洗杯等步骤，因此仅适合小型试验室，不能适应现场快速诊断的需要。
发明内容
为了克服现有技术中存在的缺点和不足，本发明的目的在于提供一种成本低廉、结果可靠、操作简单、报告快捷且能实现仪器小型化的用于床旁、现场快速检测的反应容器。
为实现上述目的，本发明的一种用于检测的反应容器，包括反应杯、样本支架及封盖，样本支架用于容设在反应杯内或/和封盖内，反应杯采用透光材料制成，反应杯设有用于容置外界的第一试剂的第一容腔，样本支架设有用于容置外界的检测样本的收集部，收集部显露于第一容腔内，封盖用于遮盖第一容腔的开口，第一容腔所容置的第一试剂用于混合收集部所容置的检测样本。
优选地，所述收集部为设置于样本支架的毛细孔，毛细孔与第一容腔连通，毛细孔用于容置外界的检测样本。
优选地，所述收集部为设置于样本支架的容置盲槽，容置盲槽位于样本支架的下端，样本支架的上端设有通液孔，通液孔用于连通容置盲槽及第一容腔。
优选地，所述用于检测的反应容器还包括刺破件及容料包，刺破件、容料包用于容设在反应杯内或/和封盖内，容料包设有用于容置外界的第二试剂的第二容腔及用于封盖第二容腔的开口的膜片，刺破件用于刺破膜片以使得第二试剂混合第一试剂及检测样本。
优选地，所述刺破件及容料包均装设于封盖内，刺破件与容料包之间具有间隙，封盖采用软性材料制成。
优选地，所述刺破件装设于反应杯，容料包装设于封盖，封盖活动设置于 反应杯。
优选地，所述刺破件具有遮盖片及自遮盖片突设而成的刺破部，遮盖片设有贯穿遮盖片的穿孔，刺破部用于刺破膜片。
优选地，所述封盖包括外帽及装设于外帽内的内帽，外帽可拆卸地连接于反应杯，内帽设有与第一容腔连通的凹槽，容料包容设于凹槽内。
优选地，所述用于检测的反应容器还包括密封圈，外帽套设于反应杯的外侧，反应杯设有环形盲槽，环形盲槽自反应杯的外表面凹设而成，密封圈容设于环形盲槽内，密封圈突伸出反应杯的外表面并用于抵触在外帽的内侧壁上。
优选地，所述反应杯设有突伸入第一容腔内的限位部，样本支架设有用于抵触限位部的支撑部，支撑部夹持于限位部与封盖之间。
本发明的有益效果：在反应容器的使用过程中，当检测只需使用一种试剂时，将预先准备好的第一试剂装入第一容腔内，将预先准备好的检测样本容设在收集部中，然后将样本支架封装在反应杯或/和封盖内，盖上封盖，而后将第一容腔所容置的第一试剂与收集部所容置的检测样本混合在一起；当检测需要用到两种试剂时，将预先准备好的第一试剂装入第一容腔内，将预先准备好的第二试剂装入容料包内，将预先准备好的检测样本容设在收集部中，然后将样本支架封装在反应杯或/和封盖内，盖上封盖，而后将第一容腔所容置的第一试剂与收集部所容置的检测样本混合在一起，而后在需要的时间施加外力使刺破件刺破容料包，使容料包内的第二试剂与第一试剂及检测样本的混合物混合。反应容器结构简单，使用方便，使检测所用的试剂按需要预先准备并按需要的时间和顺序释放，省略了加试剂、洗针、洗杯等步骤，使操作反应容器的仪器不需设置加样针、加试剂针、液路、洗涤等装置及步骤，大大简化了仪器的结构，使仪器实现小型化，成本降低，可靠性增加，同时使得操作更简单，适用于现场快速检测的需要。
附图说明
图1为本发明的结构示意图；
图2为本发明的反应杯及密封圈的剖视图；
图3为本发明的样本支架的剖视图；
图4为本发明的容料包的剖视图；
图5为本发明的刺破件的剖视图；
图6为本发明的封盖的剖视图。
附图标记包括：
1-反应杯            2-样本支架          3-封盖
4-第一容腔          5-收集部            6-毛细孔
7-刺破件            8-容料包            9-第二容腔
11-膜片             12-支撑部           121-限位部
13-锥形部           14-通液孔           15-遮盖片
16-刺破部           17-穿孔             18-外帽
19-内帽             21-凹槽             22-卡槽
23-卡块             24-密封圈           25-环形盲槽。
具体实施方式
为了便于本领域技术人员的理解，下面结合实施例及附图对本发明作进一步的说明，实施方式提及的内容并非对本发明的限定。
请参阅图1至图3所示，本发明的一种用于检测的反应容器，包括反应杯1、样本支架2及封盖3，样本支架2用于容设在反应杯1内或/和封盖3内，反应杯1大致为中空式构造，反应杯1设置有用于容置外界的第一试剂的第一容腔4，第一容腔4自反应杯1的端面凹设而成，样本支架2设置有用于容置外界的检测样本的收集部5，收集部5显露于第一容腔4内，封盖3用于遮盖第一容腔4的开口，第一容腔4所容置的第一试剂用于混合收集部5所容置的检测样本。
在反应容器的使用过程中，当检测只需要一种试剂时，将预先准备好的液体状态的第一试剂装入第一容腔4内，然后将反应杯1与封盖3安装在一起并 独立包装，进而将第一试剂紧密封装在第一容腔4内；将样本支架2单独包装；当需要对检测样本分析检测时，拆卸开反应杯1与封盖3，将检测用样本采用加样装置加于样本支架2的空置盲槽内或用样本支架2的毛细孔6定量吸取检测样本，而后将样本支架2封装在反应杯1中或/和封盖3中，而后再将反应杯1与封盖3紧密组装在一起，然后即可在控制好的时间点通过将反应容器颠倒的方式将第一容腔4所容置的第一试剂与收集部5所容置的检测样本混合在一起。
当检测需要用到两种试剂时，将预先准备好的液体状态的第一试剂装入第一容腔4内，将所需的第二试剂预先准备好封装于容料包8内，容料包8容设在反应杯1内或/和封盖3内，然后将反应杯1与封盖3安装在一起并独立包装，进而将第一试剂紧密封装在第一容腔4内，第二试剂紧密封装在容料包8内；将样本支架2单独包装；当需要对检测样本分析检测时，拆卸开反应杯1与封盖3，然后将检测用样本采用加样装置加于样本支架2的空置盲槽内或用样本支架2的毛细孔6定量吸取检测样本，而后将样本支架2封装在反应杯1中或/和封盖3中，而后再将反应杯1与封盖3紧密组装在一起，然后即可在控制好的时间点通过将反应容器颠倒的方式将第一容腔4所容置的第一试剂与收集部5所容置的检测样本混合在一起，然后可在控制好的时间点通过按压容料包8或使内帽19位移等方式使刺破件16刺破容料包8的膜片11，再通过将反应容器颠倒的方式将第一试剂、检测样本混合之后的混合物与容料包8内的第二试剂混合。
反应容器结构简单，使用方便，不仅适用于单试剂检测，也适用于双试剂检测，更重要的是其可以使检测所用的试剂按需要预先准备并按需要的时间和顺序释放，省略了加试剂、洗针、洗杯等步骤，使操作的仪器不需设置加样针、加试剂针、液路、洗涤等装置及步骤，大大简化了仪器的结构，使仪器实现小型化，成本降低，可靠性增加，同时使得操作更简单，适用于现场快速检测的需要。
所述反应杯1设置有突伸入第一容腔4内的限位部121，样本支架2设置有用于抵触限位部121的支撑部12，支撑部12夹持在限位部121与封盖3之间。在样本支架2装入到反应杯1中的过程中，当样本支架2安装到预定位置之后，限位部121挡止样本支架2的支撑部12，防止样本支架2过度装入。优选地，限位部121呈环形，如此，无论样本支架2从哪个角度装入到反应杯1中，限位部121均可以阻挡样本支架2。
本实施例中，所述样本支架2还包括与支撑部12连接的锥形部13，收集部5连接在锥形部13远离支撑部12的一端，支撑部12、锥形部13及收集部5为一体式构造。
所述收集部5为设置在样本支架2上的毛细孔6，毛细孔6与第一容腔4连通，毛细孔6用于容置外界的检测样本，样本支架2的上端设置有通液孔14，通液孔14贯穿样本支架2的侧壁，使用时，将收集部5插入到外界的检测样本中，检测样本即可在毛细现象的作用下自动进入毛细孔6内。当需要混合第一试剂及检测样本时，将反应容器颠倒，使第一试剂与检测样本接触并混合。即当反应容器向上正立时，第一容腔4所容置的第一试剂与样本支架2的收集部5中的检测样本不接触；当反应容器向下倒立时，第一容腔4所容置的第一试剂与样本支架2的收集部5中的检测样本接触混合。
所述收集部5为设置在样本支架2上的容置盲槽(图中未示出)，容置盲槽位于样本支架2的下端，通液孔14贯穿样本支架2的侧壁，通液孔14用于连通容置盲槽及第一容腔4，第一容腔4内的第一试剂位于通液孔14的下方。当检测样本装入样本支架2的容置盲槽内之后，当需要混合第一试剂及检测样本时，倒立反应容器，第一试剂淹没收集部5，第一试剂、检测样本即可经由通液孔14彼此混合。即当反应容器向上正立时，第一容腔4所容置的第一试剂与样本支架2的收集部5中的检测样本不接触；当反应容器向下倒立时，第一容腔4所容置的第一试剂与样本支架2的收集部5中的检测样本接触混合。
请参阅图1至图4所示，所述用于检测的反应容器还包括刺破件7及容料 包8，刺破件7、容料包8用于容设在反应杯1内或/和封盖3内，容料包8设置有用于容置外界的第二试剂的第二容腔9及用于封盖3第二容腔9的开口的膜片11，刺破件7用于刺破膜片11以使得第一试剂及检测样本的混合物与第二试剂混合，使得检测样本可以先后与两种试剂混合进行检测。根据实际需要，膜片11可以为塑料片或铝箔片等。
所述刺破件7及容料包8均装设在封盖3内，刺破件7与容料包8之间具有间隙，封盖3采用软性材料制成，例如，封盖3采用硅胶制成。当需要将第二试剂与第一试剂及检测样本的混合物混合时，通过挤压封盖3使得封盖3变形，变形后的封盖3连带容料包8朝靠近刺破件7的方向移动，直至刺破件7刺破膜片11，而后容料包8内的第二试剂即可释放出来与第一容腔4内的第一试剂及检测样本混合。
所述刺破件7装设在反应杯1内，容料包8装设在封盖3内，封盖3活动设置在反应杯1上。例如，封盖3可以螺接在反应杯1上，当需要第二试剂与第一试剂及检测样本的混合物混合时，通过抓持封盖3转动，使得封盖3相对反应杯1移动，反应杯1移动时连带容料包8一起移动，直至刺破件7刺破膜片11，而后容料包8内的第二试剂即可释放出来与第一容腔4内的第一试剂及检测样本混合。当然，根据实际需要，亦可将封盖3滑动设置在反应杯1上。
请参阅图1至图5所示，所述刺破件7具有遮盖片15及自遮盖片15突设而成的刺破部16，遮盖片15大致为平板状，刺破部16自遮盖片15向上突设而成，遮盖片15与刺破部16为一体式构造，遮盖片15设置有贯穿遮盖片15的穿孔17，遮盖片15位于样本支架2及容料包8之间，刺破部16用于刺破膜片11，优选地，刺破件7呈锥状，根据实际需要，刺破部16可以为棱锥形或者圆锥形，刺破部16远离遮盖片15一端的外径小于刺破部16靠近遮盖片15一端的外径，确保刺破部16可以方便地刺破容料包8的膜片11。当刺破部16刺破膜片11之后，容料包8中的第二试剂即可经由穿孔17释放出来与第一容腔4内的第一试剂及检测样本混合。
请参阅图1至图6所示，所述封盖3包括外帽18及装设在外帽18内的内帽19，外帽18可拆卸地连接在反应杯1上，内帽19上设置有与第一容腔4连通的凹槽21及与凹槽21连通的卡槽22，凹槽21自内帽19的下表面凹设而成，凹槽21未贯穿内帽19，卡槽22自凹槽21的侧壁凹设而成，容料包8容设在凹槽21内，容料包8上设置有突伸入卡槽22内的卡块23，卡块23自容料包8的外表面突设而成。
当容料包8装入到内帽19中之后，卡块23突伸入卡槽22内，卡槽22的侧壁抵触在卡块23的外表面上，防止容料包8从内帽19中脱落。当然，实际制造时，亦可不设置卡槽22，此时容料包8与凹槽21之间过盈配合，利用容料包8的外表面与凹槽21的侧壁之间的摩擦力将容料包8固定在内帽19中；优选地，内帽19采用弹性材料(如硅胶等)制成，当容料包8装入凹槽21内之后，内帽19发生弹性形变，利用内帽19的弹性回复力将容料包8紧紧固定在内帽19中。
所述用于检测的反应容器还包括密封圈24，外帽18套设在反应杯1的外侧，例如，外帽18螺接在反应杯1的外侧，反应杯1上设置有环形盲槽25，环形盲槽25自反应杯1的外表面凹设而成，密封圈24容设在环形盲槽25内，密封圈24突伸出反应杯1的外表面并用于抵触在外帽18的内侧壁上，密封圈24用于密封封盖3与反应杯1之间的间隙，防止第一容腔4内的试剂或检测样品经由封盖3与反应杯1之间的间隙漏出。本实施例中，密封圈24采用弹性材料制成，如硅胶等。
根据实际需要，所述反应杯1采用透光塑料、透光石英及透光玻璃制成，利用外界的检测光线照射反应杯1的第一容腔4内的溶液，检测第一容腔4内的溶液对特定波长光线的吸光度值的情况，进而实现对检测样本中特定待测物的检测。
本实施例中，所述第一容腔4的容积为0.05-8ml。
以上内容仅为本发明的较佳实施例，对于本领域的普通技术人员，依据本 发明的思想，在具体实施方式及应用范围上均会有改变之处，本说明书内容不应理解为对本发明的限制。

Claims (10)

  1. 一种用于检测的反应容器，其特征在于：包括反应杯、样本支架及封盖，样本支架用于容设在反应杯内或/和封盖内，反应杯采用透光材料制成，反应杯设有用于容置外界的第一试剂的第一容腔，样本支架设有用于容置外界的检测样本的收集部，收集部显露于第一容腔内，封盖用于遮盖第一容腔的开口，第一容腔所容置的第一试剂用于混合收集部所容置的检测样本。
  2. 根据权利要求1所述的用于检测的反应容器，其特征在于：所述收集部为设置于样本支架的毛细孔，毛细孔与第一容腔连通，毛细孔用于容置外界的检测样本。
  3. 根据权利要求1所述的用于检测的反应容器，其特征在于：所述收集部为设置于样本支架的容置盲槽，容置盲槽位于样本支架的下端，样本支架的上端设有通液孔，通液孔用于连通容置盲槽及第一容腔。
  4. 根据权利要求1所述的用于检测的反应容器，其特征在于：所述用于检测的反应容器还包括刺破件及容料包，刺破件、容料包用于容设在反应杯内或/和封盖内，容料包设有用于容置外界的第二试剂的第二容腔及用于封盖第二容腔的开口的膜片，刺破件用于刺破膜片以使得第二试剂混合第一试剂及检测样本。
  5. 根据权利要求4所述的用于检测的反应容器，其特征在于：所述刺破件及容料包均装设于封盖内，刺破件与容料包之间具有间隙，封盖采用软性材料制成。
  6. 根据权利要求4所述的用于检测的反应容器，其特征在于：所述刺破件装设于反应杯，容料包装设于封盖，封盖活动设置于反应杯。
  7. 根据权利要求4所述的用于检测的反应容器，其特征在于：所述刺破件具有遮盖片及自遮盖片突设而成的刺破部，遮盖片设有贯穿遮盖片的穿孔，刺破部用于刺破膜片。
  8. 根据权利要求4所述的用于检测的反应容器，其特征在于：所述封盖包括外帽及装设于外帽内的内帽，外帽可拆卸地连接于反应杯，内帽设有与第一容腔连通的凹槽，容料包容设于凹槽内。
  9. 根据权利要求8所述的用于检测的反应容器，其特征在于：所述用于检测的反应容器还包括密封圈，外帽套设于反应杯的外侧，反应杯设有环形盲槽，环形盲槽自反应杯的外表面凹设而成，密封圈容设于环形盲槽内，密封圈突伸出反应杯的外表面并用于抵触在外帽的内侧壁上。
  10. 根据权利要求1所述的用于检测的反应容器，其特征在于：所述反应杯设有突伸入第一容腔内的限位部，样本支架设有用于抵触限位部的支撑部，支撑部夹持于限位部与封盖之间。
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