WO2019205326A1 - 腔内热灌注循环管路 - Google Patents

腔内热灌注循环管路 Download PDF

Info

Publication number
WO2019205326A1
WO2019205326A1 PCT/CN2018/097599 CN2018097599W WO2019205326A1 WO 2019205326 A1 WO2019205326 A1 WO 2019205326A1 CN 2018097599 W CN2018097599 W CN 2018097599W WO 2019205326 A1 WO2019205326 A1 WO 2019205326A1
Authority
WO
WIPO (PCT)
Prior art keywords
liquid
cavity
liquid storage
cover
outlet
Prior art date
Application number
PCT/CN2018/097599
Other languages
English (en)
French (fr)
Inventor
崔书中
黄狄文
唐鸿生
唐云华
雷建平
张震
范子荣
王斌
阮强
Original Assignee
广州保瑞医疗技术有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 广州保瑞医疗技术有限公司 filed Critical 广州保瑞医疗技术有限公司
Priority to US16/954,017 priority Critical patent/US11406770B2/en
Priority to EP18915831.4A priority patent/EP3708131A4/en
Priority to AU2018421233A priority patent/AU2018421233B2/en
Publication of WO2019205326A1 publication Critical patent/WO2019205326A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/44—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media
    • A61M5/445—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests having means for cooling or heating the devices or media the media being heated in the reservoir, e.g. warming bloodbags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/0085—Devices for generating hot or cold treatment fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate
    • A61M5/16881—Regulating valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3202—Devices for protection of the needle before use, e.g. caps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0095—Heating or cooling appliances for medical or therapeutic treatment of the human body with a temperature indicator
    • A61F2007/0096—Heating or cooling appliances for medical or therapeutic treatment of the human body with a temperature indicator with a thermometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/12—Devices for heating or cooling internal body cavities
    • A61F2007/126—Devices for heating or cooling internal body cavities for invasive application, e.g. for introducing into blood vessels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow
    • A61M2205/3337—Controlling, regulating pressure or flow by means of a valve by-passing a pump
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3368—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/36—General characteristics of the apparatus related to heating or cooling
    • A61M2205/368—General characteristics of the apparatus related to heating or cooling by electromagnetic radiation, e.g. IR waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1078—Urinary tract
    • A61M2210/1085—Bladder

Definitions

  • the invention relates to the technical field of medical instruments, in particular to an intraluminal hot perfusion circulation line.
  • tumor hyperthermia confirms that the tumor tissue is heat sensitive, and the therapeutic solution is heated by a hot perfusion external heating device, and is introduced into the body cavity of the patient by a circulation pump, and the effective treatment temperature is maintained for a certain period of time to fully exert the heat.
  • the killing mechanism kills cancer cells widely spread on the serosa, eliminates the lesions that cause malignant effusion, and achieves the purpose of effectively treating cancerous effusion.
  • the hot treatment is performed with a heated therapeutic solution to prevent the diffuse spread of cancer cells in the cavity.
  • An intracavity hot perfusion circulation line comprising:
  • liquid inlet pipe having one end connected to the liquid storage chamber and the other end being connected to the liquid medicine bag;
  • liquid outlet pipe one end of which is in communication with the liquid storage chamber
  • a circulation pump connected in series with the liquid discharge line for extracting the liquid medicine in the liquid storage chamber
  • liquid return line one end of which is in communication with the other end of the pre-filling line, and the other end is in communication with the liquid storage chamber;
  • a lumen line one end of which is in communication with the other end of the outlet line, and the other end is for communicating with the body cavity;
  • the outlet conduit has one end for communicating with the body cavity and the other end for communicating with one end of the liquid return conduit, the prefill conduit being in parallel with the inlet conduit and the outlet conduit.
  • the chemical liquid When in use, the chemical liquid enters the liquid storage chamber of the heating tank through the liquid inlet line, and when the amount of the liquid medicine in the heating tank reaches a set value, the liquid inlet line is closed, and the liquid medicine in the heating tank is heated by the electromagnetic induction heating device. Preheating is carried out until the preheating temperature is reached, and the liquid medicine is pumped out of the liquid storage chamber by the circulation pump, and flows back to the heating tank through the liquid discharge line, the prefilling line and the liquid return line, so that it can be previously The air in the piping system is drained to avoid inflammation. Then, the liquid medicine is again extracted from the liquid storage chamber by the circulation pump, enters the bladder through the liquid outlet line and the inflow tube line, and then flows out from the bladder, and flows back through the outlet tube and the liquid return line. To the heating tank.
  • FIG. 1 is a schematic structural view of a heat infusion circulation line in a cavity in an embodiment
  • Figure 2 is a partial schematic view of Figure 1;
  • Figure 3 is another partial schematic view of Figure 1;
  • FIG. 4 is a schematic structural view of a heating tank in an embodiment
  • Figure 5 is a partial cross-sectional view of the heating can shown in Figure 4.
  • Figure 6 is an exploded perspective view of the heating can shown in Figure 4.
  • FIG. 7 is a schematic structural view of a two-way valve in an embodiment
  • Figure 8 is an exploded perspective view of the two-way valve shown in Figure 7;
  • FIG. 9 is a schematic structural view of another perspective view of the two-way valve shown in FIG. 7;
  • Figure 10 is a cross-sectional view taken along line A-A of Figure 9;
  • Figure 11 is an exploded perspective view of the medicated joint in an embodiment
  • Figure 12 is a cross-sectional view of the medicated joint of Figure 11 assembled
  • Figure 13 is an exploded perspective view of the inflow rate indicator in an embodiment
  • Figure 14 is a cross-sectional view of the chamber flow indicator shown in Figure 13 assembled
  • Figure 15 is an exploded perspective view of the cavity thermometer in an embodiment
  • Figure 16 is a cross-sectional view of the chamber thermometer shown in Figure 15 assembled
  • Figure 17 is an exploded perspective view of the filter in an embodiment
  • Figure 18 is a cross-sectional view of the filter of Figure 17 assembled.
  • an intracavity hot perfusion circulation line 10 in an embodiment can be applied to a bladder hot perfusion device to form a circulation line system, which is connected with a catheter placed in the bladder for treatment before being treated. Drain the air from the tubing system to avoid inflammation.
  • the chemotherapeutic drug filled into the bladder can be kept at the set hyperthermia temperature for a long time, thereby realizing the killing effect of the chemotherapeutic drug and the hyperthermia on the superficial bladder tumor.
  • it can also be applied to treatment in the chest, abdomen, and rectum.
  • the intracavity hot perfusion circulation line 10 includes a heating tank 100, an inlet line 101, an outlet line 102, a circulation pump 200, a pre-fill line 103, a liquid return line 104, The chamber line 105 and the outlet line 106 are connected.
  • the heating tank 100 is hollow to form a liquid storage chamber 100a for storing the chemical liquid.
  • One end of the inlet line 101 communicates with the reservoir chamber 100a, and the other end is used to communicate with the drug solution bag (or the drug solution bottle, the drug solution tank, etc.).
  • One end of the liquid discharge pipe 102 communicates with the liquid storage chamber 100a, and the other end communicates with one end of the prefilling pipe 103 and one end of the inlet pipe line 105, and the prefilling pipe 103 is disposed in parallel with the inlet pipe line 105.
  • a liquid suction pipe 107 may be connected in series at one end of the liquid discharge pipe 102, and the liquid suction pipe 107 extends into the liquid storage chamber 100a, and one end is close to the bottom of the heating tank 100 to ensure that the liquid medicine in the heating tank 100 can be smoothly performed. It is drawn into the discharge line 102.
  • the circulation pump 200 is connected in series to the liquid discharge line 102 for extracting the liquid medicine in the liquid storage chamber 100a.
  • the circulation pump 200 includes a pump tube 210 and two pump tube joints 220.
  • the two pump tube joints 220 are respectively connected to opposite ends of the pump tube 210 for connecting the pump tube 210 in the liquid outlet line 102.
  • the pump tube 210 is used to adjust the speed at which the liquid is extracted from the heating tank 100.
  • One end of the prefill line 103 communicates with the other end of the liquid discharge line 102, and the other end communicates with one end of the liquid return line 104.
  • the pre-filling line 103 is arranged in parallel with the inlet conduit 105 and the outlet conduit 106.
  • the pre-filling pipeline 103 is also connected in series with a pre-filling valve 1031 for controlling the opening of the pre-filling pipeline 103. close.
  • One end of the liquid return line 104 communicates with the other end of the prefill line 103 and the other end of the outlet line 106, the other end is in communication with the reservoir chamber 100a, and the return line 104 can be passed from the outlet line 106.
  • the drug solution in the derived bladder is returned to the heating tank 100.
  • the return line 104, the prefill line 103, and the outlet line 106 can be connected by a tee.
  • One end of the infusion tube line 105 communicates with the other end of the inflow line 102, and the other end is used to communicate with a body cavity (in the present embodiment, the bladder), and the infusion tube line 105 can introduce the drug solution into the bladder.
  • a cavity valve 1051 can be connected in series to the inlet conduit 105 for controlling the opening and closing of the inlet conduit 105.
  • a lumen conical head 1052 can also be provided at the other end of the lumen line 105 for facilitating engagement with the catheter.
  • a protective cap 1053 can also be sleeved on the inlet conical head 1052. The protective cap 1053 is used to protect the inlet conical head 1052 when not in use to prevent external dust or debris from entering the inlet conduit 105.
  • the outlet tube 106 is connected to the body cavity (the bladder in this embodiment), and the other end is connected to the liquid return line 104.
  • the prefill line 103 and the inlet tube 105 and the outlet line 106 are connected. Both are connected in parallel.
  • the outlet lumen 106 is capable of directing the drug solution in the bladder and returning it to the heating tank 100 via the return line 104.
  • a cavity valve 1061 can be connected in series on the outlet conduit 106, and the outlet valve 1061 is used to control the opening and closing of the outlet conduit 106.
  • a lumen conical head 1062 can also be provided at one end of the outlet lumen 106 for facilitating engagement with the catheter.
  • a protective cap 1063 can also be sleeved on the outlet cone 1062. The protective cap 1063 is used to protect the chamber cone 1062 when not in use to prevent external dust or impurities from entering the outlet conduit 106.
  • the heating can 100 is a non-deformable can.
  • the heating tank 100 includes a tank body 110 and a lid body 120.
  • the tank body 110 has a hollow shape and one end opens to form an open end.
  • the lid body 120 covers the open end of the tank body 110, and the lid body 120 and the tank body 110 together form a liquid storage body.
  • the chamber 100a, the reservoir chamber 100a is for storing a liquid.
  • the can body 110 is placed on the electromagnetic induction heating device, and the electromagnetic induction heating device is used to heat the can body 100 to indirectly heat the liquid in the liquid storage chamber 100a to realize a non-direct contact heating mode. It is possible to avoid contamination of the liquid to meet the sterility requirements.
  • the can body 110 includes a can 111 and a base 112.
  • the base 112 is disposed at the bottom of the can 110.
  • the can 111 is made of plastic.
  • the base 112 is made of metal.
  • the base 112 and the can are 111 is integrally formed by injection molding. Therefore, the entire heating tank 100 has a low cost, and the manufacturing process is simple, and is convenient for use as a disposable product.
  • the electromagnetic induction coil is energized, only the bottom of the heating tank 100 is heated, and the natural convection of the liquid in the heating tank 100 is utilized to achieve uniform heating of the liquid in the heating tank 100.
  • the base 112 can be made of medical 304 stainless steel.
  • the can body 110 has a bottom portion, and the bottom portion is away from the open end. Only the bottom of the can body 110 is made of a metal material, and the rest is made of plastic. Alternatively, the entire can body 110 may be made of a metal material. Therefore, when the electromagnetic induction coil is energized, the heating can 100 is heated to indirectly heat the liquid in the heating tank 100.
  • the heating tank 100 further includes an air filter 130 and a sealing cap 140.
  • the cover body 120 is formed with a fitting joint 150.
  • the air filter 130 communicates with the liquid storage chamber 100a through the fitting joint 150, and the sealing cap 140 is sealed.
  • the air filter 130 can be sealed.
  • the air filter 130 is mainly for preventing the bacteria or particles in the air from directly entering the liquid storage chamber 100a when the air pressure in the tank body 110 is in communication with the atmospheric pressure, thereby causing contamination of the chemical liquid.
  • the air filter 130 includes a plurality of air filter cartridges for filtering outside air to prevent bacteria carried in the air from entering the reservoir chamber 100a.
  • the air filter 130 includes a casing made of ABS, AS material, and a filter membrane made of PP, PTFE material, and the filtration rate of 0.5 micron particles in the air is greater than 90%.
  • the air filter 130 is coupled to the mating joint 150 by a threaded fit.
  • the air filter 130 is provided with a through hole, and the air filter element is located in the through hole.
  • the sealing cap 140 is rotatably disposed on the air filter 130 and can seal the through hole.
  • the sealing cap 140 is mainly for adjusting the pressure in the liquid storage chamber 100a. Since the can body 110 is made of a non-deformable material, when the capacity of the chemical liquid in the can body 110 changes, the pressure inside the can body 110 is caused. Variety.
  • the pressure in the can body 110 increases simultaneously with the increase of the chemical liquid, and eventually the pressure in the can body 110 may be equal to the pressure of the injected chemical solution, and the liquid medicine may not be injected again.
  • the tank 110 is fully loaded, when the liquid in the liquid storage chamber 100a is extracted, a negative pressure is generated in the liquid storage chamber 100a. At this time, by adjusting the negative pressure, the bladder can be assisted. The liquid is sucked out.
  • the heating tank 100 further includes a first temperature measuring component 160 for accurately measuring the temperature of the liquid in the liquid storage chamber 100a to monitor the temperature of the liquid in real time.
  • the first temperature measuring component 160 includes a first temperature sensor and a first hollow tube.
  • the first temperature sensor has a first probe end. The first probe end extends into the first hollow tube and is located at the end of the first hollow tube.
  • One end of the tube extends into the reservoir chamber 100a and is disposed near the bottom of the can body 110.
  • the first temperature measuring component 160 is always in contact with the liquid, and the actual temperature of the liquid is measured, instead of the temperature of the air leaving the liquid surface, but the first temperature measuring component 160 has a certain distance between one end and the bottom to avoid being affected.
  • the influence of the electromagnetic induction heating device causes self-heating or interference, resulting in inaccurate measurement.
  • the heating tank 100 further includes a stirring impeller 170 located in the liquid storage chamber 100a and located below the liquid return line 104, and the stirring impeller 170 can be returned to the liquid returning from the liquid return line 104 to the liquid storage chamber 100a.
  • the agitating impeller 170 is disposed on the side of the lid body 120 facing the can body 110 through the support frame 180.
  • the agitating impeller 170 includes a stirring blade 171 and a rotating shaft 172. Both ends of the rotating shaft 172 are rotatably disposed on the support frame 180, and the stirring blade 171 is fixed to the rotating shaft 172.
  • the rotating shaft 172 can also be fixed to the support frame 180, and the stirring blade 171 can be rotated relative to the rotating shaft 172.
  • the electromagnetic induction heating device indirectly heats the liquid through the heating tank 100. Since the base 112 of the can body 110 or the bottom of the can body 110 is made of stainless steel, heat is transferred from the bottom of the can body 110 to the liquid, and the density of the liquid is lowered after being heated, and naturally rises, and the liquid having a low upper temperature sinks. The process of producing natural convection. In this process, the agitating impeller 170 is also rotated, thereby acting as a stirring.
  • the intracavity hot perfusion circulation line 10 further includes a pressure measuring assembly 300.
  • the pressure measuring assembly 300 is serially connected to the liquid discharging line 102 and located behind the working position of the circulating pump 200, and the pressure measuring assembly. 300 is used to measure the pressure in the outlet line 102 behind the station of the circulation pump 200, so that the pressure in the outlet line 102 can be monitored to prevent the bladder from being damaged by excessive pressure or the pressure is too small. The liquid does not go inside the bladder.
  • the pressure measuring assembly 300 includes a pressure measuring extension tube 310, a pressure measuring valve 320, and a pressure measuring protective cap 330.
  • the pressure measuring extension tube 310 is serially connected to the liquid discharging line 102, and is located behind the working position of the circulating pump 200.
  • the pressure measuring valve 320 is used to control the opening and closing of the pressure measuring extension tube 310, and the pressure measuring protective cap 330 is sleeved at one end of the pressure measuring extension tube 310.
  • the pressure of the liquid medicine flowing out of the circulation pump 200 in the discharge line 102 can be monitored in real time by externally connecting the pressure measuring extension tube 310 to the pressure measuring sensor.
  • the inlet conduit 101 is provided with a pin 108 at one end for communicating with the drug solution bag, and the pin 108 is inserted into the drug solution bag to smoothly introduce the drug solution in the drug solution bag into the infusion line 101.
  • a protective cover 109 may be sleeved on the pin 108 to cover the pin 108 to prevent the pin 108 from being accidentally injured by the operator, and to prevent external impurities and dust from entering the liquid inlet pipe through the pin. Road 101.
  • the intracavity hot perfusion circulation line 10 further includes a two-way valve 400 connected in series with the liquid inlet line 101 for controlling the inlet line 101. Opening and closing.
  • the two-way valve 400 includes a valve body including a valve body 410 and a valve body 420.
  • the valve body 410 is provided with a liquid passage hole 411.
  • the liquid passage hole 411 extends in the radial direction of the valve body 410.
  • the liquid passage hole 411 may not only be limited to extend in the radial direction, for example, may be a curved through hole or the like.
  • the valve body 420 is open at least at one end and hollow inside to form a receiving cavity.
  • the valve body 410 is substantially cylindrical in shape, and the receiving cavity is substantially circular in shape to facilitate rotation of the spool 410 in the receiving cavity.
  • a first liquid inlet passage 421 and a first liquid outlet passage 431 communicating with the receiving cavity are formed on the side wall of the valve body 420.
  • One end of the valve core 410 extends into the receiving cavity, and the valve core 410 is rotatable relative to the valve body 420. So that the liquid passage hole 411 can communicate with or not communicate with the first liquid inlet passage 421 and the first liquid outlet passage 431.
  • a positioning groove is formed in the outer side wall of the valve core 410 extending into the receiving cavity, and a positioning convex ring is formed on the inner side wall of the receiving cavity to cooperate with the positioning groove. Therefore, the position of the valve body 410 and the valve body 420 can be positioned by the cooperation of the positioning groove and the positioning convex ring, and the valve core 410 can be prevented from excessively extending into the valve body 420.
  • the other end of the valve body 410 protrudes from the receiving cavity, and the other end of the valve body 410 protrudes from the operating handle 430.
  • the operating handle 430 can be manually operated to rotate the spool 410 relative to the valve body 420.
  • the motor can drive the spool 410 to rotate relative to the valve body 420 to achieve automatic switching.
  • the intracavity hot-filling circulation line 10 further includes a medicinal joint 500.
  • the medicinal joint 500 is connected in series in the liquid inlet line 101, and can be fed into the liquid through the medicated joint 500.
  • a chemotherapeutic drug or the like is injected into the tube 101.
  • the medicated connector 500 includes a medicated tube body 510, a handle 520 and a protective wing plate 530.
  • the inside of the medicated tube body 510 is formed with an infusion channel 510a, and the infusion channel 510a is in communication with the inlet conduit 101.
  • a dosing hole 511 is formed on the side wall of the dosing tube 510, and the dosing hole 511 is in communication with the infusion channel 510a.
  • the dosing tube body 510 is provided with a dosing soft plug 540 for sealing the dosing hole 511 to prevent air. Or other dust enters the piping system.
  • the dosing soft plug 540 may be a silicone plug.
  • the medicated soft plug 540 can also be made of other soft materials as long as the medicated hole 511 can be sealed and the needle tip of the syringe can be inserted.
  • the handle 520 is disposed on the outer side wall of the medicated tube body 510 and spaced apart from the medicated hole 511.
  • the protective wing 530 is disposed on the outer side wall of the medicated tube body 510 and located between the medicated hole 511 and the handle 520. To form a protective wall. Therefore, when one hand grasps the handle 520 and the other hand holds the syringe, and the needle tip of the syringe is inserted into the medicated soft plug 540, the protective flap 530 forms a protective wall between the hand and the needle tip. It can effectively prevent the needle tip from hurting the hand due to inadvertent operation.
  • the intraluminal hot perfusion circulation line 10 further includes an inflow flow indicator 600, which is connected in series to the discharge line 102.
  • the inflow flow indicator 600 is located behind the station of the pressure measuring assembly 300. The inflow flow indicator 600 can be more advantageous for observing the flow of liquid in the tubing system.
  • the inflow flow indicator 600 includes a base 610, an impeller 620, a transparent cover 630, and a dark shield upper cover 640.
  • the base 610 is formed with an impeller chamber 610a, and the impeller chamber 610a is in communication with the outlet conduit 102.
  • the impeller 620 is rotatably disposed on the base 610 via the rotating shaft 650 and located in the impeller cavity 610a.
  • the transparent cover 630 is disposed on the base 610 for sealing the impeller cavity 610a.
  • the dark cover 640 is coverably disposed on the base. 610, and can be covered on the transparent cover 630.
  • the base 610 is made of a light-proof material, and the transparent cover 630 may be made of a transparent material such as transparent plastic or transparent glass.
  • the impeller 620 is washed due to the continuity of the liquid, and the impeller 620 is rotated by the flowing liquid, and it is known whether the liquid is in a flowing state by observing whether the impeller 620 is rotated by the transparent cover 630.
  • the impeller 620 is eccentrically disposed relative to the impeller chamber 610a to accommodate lower flow rates.
  • the flow rate in the tubing system is usually between 50 ml/min and 200 ml/min, and in most cases less than 150 ml/min. Relatively slow, it is necessary to increase the sensitivity of the rotation of the impeller 620.
  • the intracavity thermal perfusion circulation line 10 further includes a cavity thermometer 700.
  • the cavity thermometer 700 is connected in series to the liquid outlet pipe 102, and the cavity temperature detector is inserted into the cavity. 700 is used to measure the temperature of the liquid flowing in the liquid line 102 in real time and truly to monitor the true temperature of the liquid entering the bladder.
  • the cavity thermometer 700 is located behind the station of the inflow flow indicator 600.
  • the cavity thermometer 700 includes a first reservoir housing 710, a second temperature measurement assembly 720, a first inlet chamber end cover 730, and a second inlet chamber end cover 740.
  • the inside of the first liquid storage case 710 is hollow to form a first liquid storage chamber 710a, and the first liquid storage chamber 710a is in communication with the liquid discharge line 102.
  • the first liquid storage housing 710 includes a first small diameter end 711 and a first large diameter end. The inner diameter of the first small diameter end 711 is smaller than the inner diameter of the first large diameter end 712.
  • the second temperature measuring component 720 includes a second hollow tube 721 and a second temperature sensor.
  • the second temperature sensor has a second probe end 722.
  • the second probe end 722 extends into the second hollow tube 721 and is located at the end of the second hollow tube 721.
  • the first inlet end cover 730 covers the first large diameter end 712 of the first liquid storage housing 710, and the second inlet end surface cover 740 is disposed at the first small diameter end 711 of the first liquid storage housing 710.
  • the second hollow tube 721 extends from the first inlet end cap 730 into the first reservoir 710a and is adjacent to the first inlet passage 741 on the second inlet end cap 740.
  • the first reservoir housing 710 will Heat is inevitable, so the measured temperature is 1-2 ° C lower than the actual temperature of the liquid. If the second probe end 722 of the second temperature sensor is located in the middle of the first reservoir 710a, the measured temperature will be higher than the dead water zone or the flow rate being slower than the actual flow velocity of the liquid in the pipeline. The actual temperature of the liquid is 1 °C lower. Therefore, in the present embodiment, the second probe end 722 is disposed adjacent to the first liquid inlet through hole, but is not in direct contact with the first liquid storage case 710.
  • the intracavity hot perfusion circulation line 10 further includes an out-of-cavity temperature detector 700' connected in series in the liquid return line 104 for measuring real-time and true measurement from the bladder via The temperature of the liquid flowing out of the outlet line 106.
  • the structure of the outlet cavity temperature detector 700' is substantially the same as that of the inlet cavity temperature detector 700.
  • the outlet cavity thermometer 700' includes a second reservoir housing, a third temperature measuring assembly, a first outlet end cap, and a second outlet end cap.
  • the inside of the second liquid storage case is hollow to form a second liquid storage chamber, and the second liquid storage chamber is in communication with the liquid return line 104.
  • the second liquid storage housing includes a second small diameter end and a second large diameter end disposed opposite to each other, and an inner diameter of the second small diameter end is smaller than an inner diameter of the second large diameter end.
  • the third temperature measuring component comprises a third hollow tube and a third temperature sensor, the third temperature sensor has a third probe end, the third probe end extends into the third hollow tube and is located at the end of the third hollow tube, the first cavity
  • the end cover covers the second large diameter end of the second liquid storage case, and the second outlet end cover is disposed at the second small diameter end of the second liquid storage case.
  • the third hollow tube extends from the first outlet end cover into the second liquid storage chamber and is adjacent to the second liquid inlet through hole on the second outlet end cover.
  • the measured temperature is 1-2 ° C lower than the actual temperature of the liquid. If the third probe end of the third temperature sensor is located in the middle of the second liquid storage chamber, the measured temperature will be higher than that of the liquid because there is a dead water zone or the flow rate is slower than the actual flow velocity of the liquid in the pipeline. The actual temperature is 1 °C lower. Therefore, in the present embodiment, the third probe end is disposed adjacent to the second liquid inlet through hole, but is not in direct contact with the second liquid storage case.
  • the intracavity hot perfusion circulation line 10 further includes a filter 800, which is serially connected to the liquid return line 104.
  • the filter 800 is located behind the station of the chamber thermometer 700'.
  • the filter 800 can filter the liquid medicine flowing out of the bladder to prevent the detached tissue from damaging other components.
  • the filter 800 includes a housing 810, a filter cartridge 820, an upper cover 830, and a lower cover 840.
  • the housing 810 is formed with a filter chamber 810a.
  • the filter chamber 810a is in communication with the liquid return line 104.
  • the filter element 820 is received in the filter chamber 810a.
  • the filter element 820 is used to filter the liquid medicine.
  • the housing 810 may have a hollow cylindrical shape.
  • the filter element 820 includes a bracket 821 and a filter 822, and the filter screen 822 is disposed on the bracket 821.
  • the upper cover 830 is disposed at one end of the housing 810, and the lower cover 840 is disposed at the other end of the housing 810.
  • the side wall of the one end of the housing 810 protrudes outwardly to form a positioning step 811.
  • the bracket 821 includes a positioning cylinder 8211 and at least two reinforcing ribs 8212.
  • the positioning cylinder 8211 abuts the positioning step 811, and one end of the reinforcing rib 8212 is disposed on the positioning cylinder 8211.
  • Upper, and the ribs 8212 are radially spaced apart.
  • the intraluminal thermal perfusion circulation line 10 further includes an outflow flow indicator 600' which is connected in series with the return line 104.
  • the outlet flow indicator 600' is connected in series behind the station of the filter 800.
  • the structure of the outlet flow indicator 600' is substantially the same as that of the inlet flow indicator 600.
  • the outlet flow indicator 600' includes a base 610, an impeller 620, a transparent cover 630, and a light shield upper cover 640.
  • the base 610 is formed with an impeller chamber 610a, and the impeller chamber 610a is in communication with the liquid return line 104.
  • the impeller 620 is rotatably disposed on the base 610 through the rotating shaft and located in the impeller cavity 610a.
  • the transparent cover 630 is disposed on the base 610 for sealing the impeller cavity 610a.
  • the dark cover 830640 can be disposed on the base 610. It can be overlaid on the transparent cover 630.
  • the base 610 is made of a light-proof material, and the transparent cover 630 may be made of a transparent material such as transparent plastic or transparent glass.
  • the impeller 620 is washed due to the continuity of the liquid, and the impeller 620 is rotated by the flowing liquid, and it is known whether the liquid is in a flowing state by observing whether the impeller 620 is rotated by the transparent cover 630.
  • the impeller 620 is eccentrically disposed relative to the impeller chamber 610a to accommodate lower flow rates.
  • the flow rate in the tubing system is usually between 50 ml/min and 200 ml/min, and in most cases less than 150 ml/min. Relatively slow, it is necessary to increase the sensitivity of the rotation of the impeller 620.
  • the intracavity hot perfusion circulation line 10 further includes a flow regulating valve 900.
  • the flow regulating valve 900 is serially connected to the liquid return line 104.
  • the flow regulating valve 900 is located at the outgoing flow indicator. Behind the station, the flow regulating valve 900 is used to adjust the flow rate of the liquid in the liquid return line 104.
  • the inlet line 101, the outlet line 102, the pre-fill line 103, the inlet line 105, the outlet line 106, and the return line 104 can all be made of a hose made of a soft material.
  • the hose can also be protected from light to meet the need for certain drugs for bladder chemotherapy to be protected from light.
  • the regulating valve 900 can be connected in series to the pipeline system through a pure physical connection of the joint 20 and the locking sleeve 30 to prevent the adhesive residue.
  • the joint 20 is formed with a passage 20a through which the liquid communicates with the piping system.
  • the joint 20 includes a mating section 21 and a connecting section 22, and the outer side wall of the mating section 21 is formed with a first protrusion 23, and the outer side wall of the connecting section 22 is a conical surface.
  • the locking sleeve 30 includes a first locking portion 31 and a second locking portion 32.
  • the inner side wall of the first locking portion 31 is formed with a second protrusion 33 that cooperates with the first protrusion 23, and the second locking portion
  • the inner side wall of the segment 32 is formed with a pressing portion, and the hose is pressed between the pressing portion and the connecting portion 22.
  • the locking sleeve 30 When the locking sleeve 30 is engaged with the joint, the locking sleeve 30 is inserted into the hose in advance, and then one end of the hose is sleeved on the connecting portion 22 of the joint, and the hose is inserted into the connecting portion 22, and is connected. Segment 22 is large. The locking sleeve 30 is moved until the second protrusion 33 of the inner side wall of the first locking sleeve 30 passes the first protrusion 23 of the outer side wall of the fitting section 21, and the pressing portion of the inner side wall of the second locking section 32 will The hose has a certain compression effect so that the hose can be pressed between the connecting section 22 and the second locking section 32 to prevent the hose from coming off the joint.
  • the above-described intracavity hot perfusion circulation line 10 has at least the following advantages:
  • the prefill valve 1031 is opened, and the inlet valve 1051 and the outlet valve 1061 are closed.
  • the liquid medicine is extracted from the liquid storage chamber 100a by the circulation pump 200, and the pressure measuring assembly 300 is externally connected to the pressure measuring sensor. The pressure of the liquid is measured.
  • the liquid medicine passes through the cavity flow indicator 600 on the liquid outlet pipe 102, enters the cavity temperature detector 700, and then enters the pre-charge line 103, and then passes through the cavity temperature detector 700' on the liquid return line 104,
  • the filter 800, the outlet flow indicator 600', and the flow regulating valve 900 are returned to the heating tank 100.
  • the chemical liquid flows back to the heating tank 100 through the liquid discharge line 102, the pre-filling line 103, and the liquid return line 104, so that the air in the piping system can be drained in advance to avoid inflammation.
  • the pre-fill valve 1031 is closed, and the inlet valve 1051 and the outlet valve 1061 are opened, and the chemical liquid is again extracted from the liquid storage chamber 100a by the circulation pump 200, and enters through the liquid outlet line 102 and the inlet chamber 105.
  • the bladder then flows out of the bladder and flows back to the heating tank 100 via the outlet conduit 106 and the return conduit 104.
  • the heating tank 100 can continue to heat the liquid until the set temperature is reached, and the purpose of the side circulation and the temperature rise is not achieved, so that the temperature of the liquid solution is not rapidly increased at the beginning to avoid bladder contraction. Or ⁇ .

Abstract

一种腔内热灌注循环管路（10），包括加热罐（100）、进液管路（101）、出液管路（102）、循环泵（200）、预充管路（103）、回液管路（104）、入腔管路（105）及出腔管路（106），加热罐（100）内形成储液腔（100a），进液管路（101）与储液腔（100a）相连通，药液经由进液管路（101）进入加热罐（100）的储液腔（100a）内，当加热罐（100）中的药液量达到设定值时关闭进液管路（101），通过电磁感应加热装置对加热罐（100）内的药液进行预加热直到达到预热温度，药液在循环泵（200）的作用下被抽取出储液腔（100a），经由出液管路（102）、预充管路（103）及回液管路（104）后流回加热罐（100）中，因此可以预先将管路系统中的空气排掉以避免引发炎症。然后药液在循环泵（200）的作用下再次被抽取出储液腔（100a），经由出液管路（102）、入腔管路（105）后进入膀胱中，然后从膀胱中流出，经由出腔管路（106）、回液管路（104）流回至加热罐（100）中。

Description

腔内热灌注循环管路 技术领域
本发明涉及医疗器械技术领域，特别是涉及一种腔内热灌注循环管路。
背景技术
肿瘤被切除后或减状手术后，需要向该患者腔内(例如胸腔、腹腔或膀胱等)直接灌注加热的生理盐水和抗癌药物，使抗癌药物直接且充分地与肿瘤组织或细胞接触，起到辅助化疗的作用。肿瘤热疗学基础研究证实肿瘤组织具有热敏感性，利用热灌注体外加热装置，将治疗液加热，用循环泵将其导入病人的体腔，在一定的时间内保持有效治疗温度，以充分发挥热杀伤机制，对广泛种植在浆膜上转移癌细胞杀伤，消除引发恶性积液的病灶，达到有效治疗癌性积液的目的。在术中、术后利用加热的治疗液进行热清扫，可预防癌细胞在腔体弥漫性扩散。
然而，利用传统的循环管路进行热灌注循环治疗时，无法将管路系统内的空气排掉，若体腔内进入过多空气，则可能会引发炎症等症状。
发明内容
基于此，有必要针对上述技术问题，提供一种可以预先将管路系统中的空气排掉以避免引发炎症的腔内热灌注循环管路。
一种腔内热灌注循环管路，包括：
加热罐，呈中空状以形成储液腔，所述储液腔用于储存药液；
进液管路，一端与所述储液腔相连通，另一端用于与药液袋相连通；
出液管路，一端与所述储液腔相连通；
循环泵，串接于所述出液管路中，用于将所述储液腔中的药液抽出；
预充管路，一端与所述出液管路的另一端相连通；
回液管路，一端与所述预充管路的另一端相连通，另一端与所述储液腔相连通；
入腔管路，一端与所述出液管路的另一端相连通，另一端用于与体腔相连通；及
出腔管路，一端用于与体腔相连通，另一端与所述回液管路的一端相连通，所述预充管路与所述入腔管路及所述出腔管路并联。
上述腔内热灌注循环管路至少具有以下优点：
使用时，药液经由进液管路进入加热罐的储液腔内，当加热罐中的药液量达到设定值时关闭进液管路，通过电磁感应加热装置对加热罐内的药液进行预加热直到达到预热温度，药液在循环泵的作用下被抽取出储液腔，经由出液管路、预充管路及回液管路后流回加热罐中，因此可以预先将管路系统中的空气排掉以避免引发炎症。然后药液在循环泵的作用下再次被抽取出储液腔，经由出液管路、入腔管路后进入膀胱中，然后从膀胱中流出，经由出腔管路、回液管路流回至加热罐中。
附图说明
图1为一实施方式中的腔内热灌注循环管路的结构示意图；
图2为图1中的局部示意图；
图3为图1中的另一局部示意图；
图4为一实施方式中的加热罐的结构示意图；
图5为图4所示加热罐的部分剖视图；
图6为图4所示加热罐的分解示意图；
图7为一实施方式中的二通阀的结构示意图；
图8为图7所示二通阀的分解示意图；
图9为图7所示二通阀的另一视角的结构示意图；
图10为沿图9中A-A线的剖视图；
图11为一实施方式中的加药接头的分解示意图；
图12为图11所示加药接头组装好后的剖视图；
图13为一实施方式中的入腔流量指示器的分解示意图；
图14为图13所示的入腔流量指示器组装好后的剖视图；
图15为一实施方式中的入腔测温器的分解示意图；
图16为图15所示入腔测温器组装好后的剖视图；
图17为一实施方式中的过滤器的分解示意图；
图18为图17所示的过滤器组装好后的剖视图。
具体实施方式
为使本发明的上述目的、特征和优点能够更加明显易懂，下面结合附图对本发明的具体实施方式做详细的说明。在下面的描述中阐述了很多具体细节以便于充分理解本发明。但是本发明能够以很多不同于在此描述的其它方式来实施，本领域技术人员可以在不违背本发明内涵的情况下做类似改进，因此本发明不受下面公开的具体实施的限制。
需要说明的是，当元件被称为“固定于”另一个元件，它可以直接在另一个元件上或者也可以存在居中的元件。当一个元件被认为是“连接”另一个元件，它可以是直接连接到另一个元件或者可能同时存在居中元件。本文所使用的术语“垂直的”、“水平的”、“左”、“右”以及类似的表述只是为了说明的目的，并不表示是唯一的实施方式。
除非另有定义，本文所使用的所有的技术和科学术语与属于本发明的技术领域的技术人员通常理解的含义相同。本文中在本发明的说明书中所使用的术语只是为了描述具体的实施例的目的，不是旨在于限制本发明。以上所述实施例的各技术特征可以进行任意的组合，为使描述简洁，未对上述实施例中的各个技术特征所有可能的组合都进行描述，然而，只要这些技术特征的组合不存在矛盾，都应当认为是本说明书记载的范围。
请参阅图1，一实施方式中的腔内热灌注循环管路10，可以应用于膀胱热灌注装置中，以形成循环管路系统，与放置在膀胱的导尿管连接，进行治疗前，能够预先将管路系统中的空气排掉，以避免引发炎症。而且与电磁感应加热装置配合使用，能够实现充盈到膀胱的化疗药物在长时间保持在设定热疗温度，从而实现化疗药物和热疗针对浅表性膀胱肿瘤的杀灭作用。当然，在其它的实施方式中，还可以应用在胸腔、腹腔、直肠中进行治疗。
请一并参阅图2及图3，腔内热灌注循环管路10包括加热罐100、进液管路101、出液管路102、循环泵200、预充管路103、回液管路104、入腔管路105及出腔管路106。加热罐100呈中空状以形成储液腔100a，储液腔100a用于储存药液。进液管路101的一端与储液腔100a相连通，另一端用于与药液袋(或者药液瓶、药液罐等)相连通。出液管路102的一端与储液腔100a相连通，另一端与预充管路103的一端及入腔管路105的一端相连通，预充管路103与入腔管路105相并联设置。例如，可以在出液管路102的一端串接一吸液管107，吸液管107伸入储液腔100a内，且一端靠近加热罐100底部，以保证加热罐100中的药液能够顺利被抽取至出液管路102中。
循环泵200串接于出液管路102中，用于将储液腔100a中的药液抽出。具体地，循环泵200包括泵管210及两个泵管接头220，两个泵管接头220分别连接于泵管210的相对两端，用于将泵管210串接于出液管路102中，泵管210用于调节从加热罐100中抽取液体的速度。
预充管路103的一端与出液管路102的另一端相连通，另一端与回液管路104的一端相连通。预充管路103与入腔管路105及出腔管路106均并联设置，预充管路103上还串接有预充阀1031，预充阀1031用于控制预充管路103的开闭。回液管路104的一端与预充管路 103的另一端及出腔管路106的另一端相连通，另一端与储液腔100a相连通，回液管路104能够将由出腔管路106导出的膀胱中的药液回流至加热罐100中。例如可以通过三通管来连接回液管路104、预充管路103及出腔管路106。
入腔管路105的一端与出液管路102的另一端相连通，另一端用于与体腔(本实施方式中为膀胱)相连通，入腔管路105能够将药液导入膀胱中。具体地，可以在入腔管路105上串接一入腔阀1051，用于控制入腔管路105的开闭。还可以在入腔管路105的另一端设置入腔圆锥头1052，用于方便与导尿管相配合。可选地，还可以在入腔圆锥头1052上套设一保护帽1053，保护帽1053用于在不使用时保护入腔圆锥头1052，防止外界灰尘或杂物进入入腔管路105中。
出腔管路106的一端用于与体腔(本实施方式中为膀胱)相连通，另一端与回液管路104相连通，预充管路103与入腔管路105及出腔管路106均并联。出腔管路106能够将膀胱中的药液导出来，并经由回液管路104回流至加热罐100中。具体地，可以在出腔管路106上串接一出腔阀1061，出腔阀1061用于控制出腔管路106的开闭。还可以在出腔管路106的一端设置出腔圆锥头1062，用于方便与导尿管相配合。可选地，还可以在出腔圆锥头1062上套设一保护帽1063，保护帽1063用于在不使用时保护出腔圆锥头1062，防止外界灰尘或杂质进入出腔管路106中。
请参阅图4至图6，加热罐100为不可变形的罐子。加热罐100包括罐体110及盖体120，罐体110呈中空状且一端开口形成开口端，盖体120盖设于罐体110的开口端，盖体120与罐体110共同围成储液腔100a，储液腔100a用于存储液体。其中，在使用时，罐体110用于放置于电磁感应加热装置上，电磁感应加热装置用于加热罐100体，以间接加热储液腔100a内的液体，实现非直接接触式的加热方式，可以避免药液被污染，从而满足无菌要求。
具体到本实施方式中，罐体110包括罐壳111及基座112，基座112设置于罐体110的底部，罐壳111为塑料材质，基座112为金属材质，基座112与罐壳111通过注塑方式一体成型。因此，整个加热罐100的造价成本较低，而且制作工艺简单，便于作为一次性产品使用。当电磁感应线圈通电时，仅对加热罐100的底部加热，并利用加热罐100中液体的自然对流作用，实现对加热罐100中液体的均匀加热。例如，基座112可以为医用304不锈钢制成。
当然，在其它的实施方式中，罐体110具有底部，底部远离开口端，仅罐体110的底部为金属材质制成，其余部分为塑料制成。或者，也可以罐体110整体为金属材质制成，因此当电磁感应线圈通电后，用于对加热罐100进行加热，从而间接地对加热罐100内的液体进行加热。
具体到本实施方式中，加热罐100还包括空气过滤器130及密封帽140，盖体120上形成有配合接头150，空气过滤器130通过配合接头150与储液腔100a相连通，密封帽140能够密封空气过滤器130。空气过滤器130主要是为了当罐体110内的气压与大气压相通时，避免空气中的细菌或微粒直接进入到储液腔100a中，造成药液的污染。具体地，空气过滤器130包括多层空气滤芯，用于对外界空气进行过滤，防止空气中携带的细菌进入储液腔100a中。例如，空气过滤器130包括由ABS、AS材料制成的壳体和PP、PTFE材料制成的过滤膜，对空气中0.5微米的微粒的滤除率大于90％。
具体地，空气过滤器130与配合接头150通过螺纹配合方式相连接。空气过滤器130上开设有通孔，空气滤芯位于通孔内，密封帽140可旋转地设置于空气过滤器130上，且能够密封通孔。密封帽140主要是为了调节储液腔100a中的压力，由于罐体110为不可变形的材料制成，当罐体110内的药液的容量发生变化时，会造成罐体110内的压力的变化。比如当往加热罐100注入药液时，随着药液的增加，罐体110内压力也同时增加，最终可能导致罐体110内的压力与注入药液压力相等而无法再注入药液。或者当罐体110内为满载时，当将储液腔100a中的药液抽取之后，储液腔100a内会产生负压，此时，通过调整此负压大小，可以有助于将膀胱内的药液吸出。
具体到本实施方式中，加热罐100还包括第一测温组件160，第一测温组件160用于精确测量储液腔100a中液体的温度，以实时监测液体的温度。第一测温组件160包括第一温度传感器及第一空心管，第一温度传感器具有第一探头端，第一探头端伸入第一空心管且位于第一空心管的端部，第一空心管的一端伸入储液腔100a中，且靠近罐体110的底部设置。使得第一测温组件160始终能与液体接触，保证测量到液体的真实温度，而不是离开液面的空气温度，但第一测温组件160的一端与底部之间具有一定的间距，避免受电磁感应加热装置的影响而导致自身发热或受到干扰，造成测量不准。
加热罐100还包括搅拌叶轮170，搅拌叶轮170位于储液腔100a内，且位于回液管路104的下方，搅拌叶轮170能够在由回液管路104回流至储液腔100a的液体的作用下转动。具体地，搅拌叶轮170通过支撑架180设置于盖体120朝向罐体110的一侧。搅拌叶轮170包括搅拌叶片171及转轴172，转轴172的两端可转动地设置于支撑架180上，搅拌叶片171固定于转轴172上。当然，在其它的实施方式中，转轴172也可以固定于支撑架180上，搅拌叶片171相对于转轴172可转动。
当储液腔100a中充满液体时，电磁感应加热装置通过加热罐100体间接对液体进行加热。由于罐体110的基座112或罐体110的底部为不锈钢材质，因此热量由罐体110的底部传递给液体，液体受热后密度降低，自然会上浮，上方温度低的液体就会下沉，产生自然对流的过程。在这个过程中，会造成搅拌叶轮170也会转动，从而起到一个搅拌的作用。
请再次参阅图1及图2，腔内热灌注循环管路10还包括测压组件300，测压组件300串接于出液管路102上，且位于循环泵200的工位后方，测压组件300用于测量循环泵200的工位后方的出液管路102内的压力，因此可以对出液管路102内的压力进行监测，防止压力过大对膀胱造成伤害，或者压力过小，药液进不去膀胱内。
具体地，测压组件300包括测压延长管310、测压阀320及测压保护帽330，测压延长管310串接于出液管路102上，且位于循环泵200的工位后方，测压阀320用于控制测压延长管310的开闭，测压保护帽330套设于测压延长管310的一端。可以通过将测压延长管310外接在测压传感器上，来实时监测经循环泵200流出后的药液在出液管路102中的压力。
进液管路101用于与药液袋相连通的一端设置有插针108，插针108用于插入药液袋中，以将药液袋中的药液顺利导入进液管路101中。可选地，还可以在插针108上套设一保护盖109，以对插针108进行遮盖，防止插针108误扎伤操作者，也能够防止外界杂质与灰尘通过插针进入进液管路101中。
请一并参阅图2、图7至图10，腔内热灌注循环管路10还包括二通阀400，二通阀400串接于进液管路101中，用于控制进液管路101的开闭。二通阀400包括阀本体，阀本体包括阀芯410及阀体420。阀芯410上开设有通液孔411，例如，通液孔411沿阀芯410的径向延伸。当然，在其它的实施方式中，通液孔411还可以不仅仅限于沿径向延伸，例如还可以为弯曲状的通孔等等。
阀体420至少一端开口且内部呈中空状以形成收容腔。阀芯410大致为圆柱体形状，收容腔大致为圆形孔，以方便阀芯410在收容腔内转动。阀体420的侧壁上形成有与收容腔相连通的第一进液通道421及第一出液通道431，阀芯410的一端伸入收容腔，且阀芯410相对于阀体420可转动，以使通液孔411能够与第一进液通道421及第一出液通道431相连通或不连通。
具体到本实施方式中，阀芯410伸入收容腔的一端的外侧壁上凹陷形成有定位槽，收容腔的内侧壁上突出形成有与定位槽相配合的定位凸环。因此可以通过定位槽与定位凸环的配合来定位阀芯410与阀体420的位置，防止阀芯410过度伸入阀体420内。
具体到本实施方式中，阀芯410的另一端伸出于收容腔，且阀芯410的另一端突出形成有操作把手430。可以通过手动方式操作该操作把手430，来使得阀芯410相对于阀体420转动。当然，在其它的实施方式中，还可以通过电机驱动阀芯410相对于阀体420转动，实现 自动通断的目的。
请一并参阅图2、图11及图12，腔内热灌注循环管路10还包括加药接头500，加药接头500串接于进液管路101中，可以通过加药接头500往进液管路101中注入化疗药物等等。加药接头500包括加药管体510、把手520及保护翼板530，加药管体510的内部形成有输液通道510a，输液通道510a与进液管路101相连通。加药管体510的侧壁上形成有加药孔511，加药孔511与输液通道510a相连通，加药管体510上设置有用于密封加药孔511的加药软塞540，防止空气或其它灰尘进入管路系统中。具体地，加药软塞540可以为硅胶塞。当然，在其它的实施方式中，加药软塞540也可以为其它软性材质制成，只要能够密封加药孔511，且能够供注射器的针尖插入即可。
把手520设置于加药管体510的外侧壁上，且与加药孔511间隔设置，保护翼板530设置于加药管体510的外侧壁上，且位于加药孔511与把手520之间以形成保护墙。因此，当一只手抓住把手520，另一只手拿着注射器，将注射器的针尖插入加药软塞540中时，保护翼板530形成一堵隔在手与针尖之间的保护墙，可以有效防止由于操作不慎导致针尖伤到手。
请参阅图3、图13及图14，腔内热灌注循环管路10还包括入腔流量指示器600，入腔流量指示器600串接于出液管路102中。例如，本实施方式中，入腔流量指示器600位于测压组件300的工位后方。入腔流量指示器600可以更有利于观察管路系统中的液体的流动状况。
具体地，入腔流量指示器600包括底座610、叶轮620、透明盖体630及避光上盖640，底座610形成有叶轮腔610a，叶轮腔610a与出液管路102相连通。叶轮620通过转轴650可转动地设置于底座610上，且位于叶轮腔610a内，透明盖体630设置在底座610上，用于密封叶轮腔610a，避光上盖640可盖合地设置于底座610上，且能够覆盖在透明盖体630上。
底座610为避光材料制成，透明盖体630可以为透明材质制成，例如透明塑料或者透明玻璃等等。当液体进入叶轮腔610a时，由于液体的连续性，会冲刷叶轮620，叶轮620在流动的液体的作用下转动，通过透明盖体630观察叶轮620是否转动即可知晓液体是否处于流动状态。
叶轮620相对于叶轮腔610a偏心设置，以适应较低的流速。如当流量指示器应用到膀胱循环热灌注装置时，在进行治疗时，管路系统中的流速通常在50ml/min～200ml/min之间，大多数情况下低于150ml/min，这样的速度相对来说是很慢的，因此需要增加叶轮620转动的灵敏度。
请一并参阅图3、图15至图16，腔内热灌注循环管路10还包括入腔测温器700，入腔测温器700串接于出液管路102中，入腔测温器700用于实时且真实地测量出液管路102中流动的液体的温度，以监测进入膀胱中液体的真实温度。例如，本实施方式中，入腔测温器700位于入腔流量指示器600的工位后方。
入腔测温器700包括第一储液壳体710、第二测温组件720、第一入腔端盖730及第二入腔端盖740。第一储液壳体710内部呈中空状以形成第一储液室710a，第一储液室710a与出液管路102相连通。第一储液壳体710包括相对设置的第一小径端711与第一大径端，第一小径端711的内径小于第一大径端712的内径。
第二测温组件720包括第二空心管721及第二温度传感器，第二温度传感器具有第二探头端722，第二探头端722伸入第二空心管721且位于第二空心管721的端部，第一入腔端盖730覆盖在第一储液壳体710的第一大径端712，第二入腔端盖740设置在第一储液壳体710的第一小径端711。其中，第二空心管721由第一入腔端盖730伸入第一储液室710a内，且邻近于第二入腔端盖740上的第一进液通孔741。
若第二温度传感器的第二探头端722过于靠近第一储液壳体710的侧壁或直接与第一储液壳体710的侧壁相贴附，那么由于第一储液壳体710会不可避免的存在散热，因此会导致测量出来的温度比液体的实际温度低1-2℃。若第二温度传感器的第二探头端722位于第一储 液室710a的中部，由于该处会存在死水区或流速慢于管路中液体的实际流动速度，因此所测得的温度也会比液体的实际温度低1℃。因此，本实施方式中，将第二探头端722设置于邻近第一进液通孔，但又不与第一储液壳体710直接接触。
请参阅图3，腔内热灌注循环管路10还包括出腔测温器700’，出腔测温器700’串接于回液管路104中，用于测量实时且真实地测量从膀胱经由出腔管路106流出来的液体的温度。具体地，出腔测温器700’的结构与入腔测温器700的结构大致相同。
出腔测温器700’包括第二储液壳体、第三测温组件、第一出腔端盖及第二出腔端盖。第二储液壳体内部呈中空状以形成第二储液室，第二储液室与回液管路104相连通。第二储液壳体包括相对设置的第二小径端与第二大径端，第二小径端的内径小于第二大径端的内径。
第三测温组件包括第三空心管及第三温度传感器，第三温度传感器具有第三探头端，第三探头端伸入第三空心管且位于第三空心管的端部，第一出腔端盖覆盖在第二储液壳体的第二大径端，第二出腔端盖设置在第二储液壳体的第二小径端。其中，第三空心管由第一出腔端盖伸入第二储液室内，且邻近于第二出腔端盖上的第二进液通孔。
若第三温度传感器的第三探头端过于靠近第二储液壳体的侧壁或直接与第二储液壳体的侧壁相贴附，那么由于第二储液壳体会不可避免的存在散热，因此会导致测量出来的温度比液体的实际温度低1-2℃。若第三温度传感器的第三探头端位于第二储液室的中部，由于该处会存在死水区或流速慢于管路中液体的实际流动速度，因此所测得的温度也会比液体的实际温度低1℃。因此，本实施方式中，将第三探头端设置于邻近第二进液通孔，但又不与第二储液壳体直接接触。
请一并参阅图2、图17及图18，腔内热灌注循环管路10还包括过滤器800，过滤器800串接于回液管路104中。例如，过滤器800位于出腔测温器700’的工位后方。过滤器800可以过滤从膀胱中流出的药液，以防止脱落的组织对其它零部件造成损坏。
具体地，过滤器800包括壳体810、滤芯820、上盖830及下盖840。壳体810形成有滤芯腔810a，滤芯腔810a与回液管路104相连通，滤芯820收容于滤芯腔810a内，滤芯820用于过滤药液。具体地，壳体810可以为空心圆柱体状。滤芯820包括支架821及滤网822，滤网822设置于支架821上。上盖830设置于壳体810的一端，下盖840设置于壳体810的另一端。
壳体810的一端的侧壁向外突出形成定位台阶811，支架821包括定位圆柱8211及至少两根加强筋8212，定位圆柱8211与定位台阶811相抵接，加强筋8212的一端设置于定位圆柱8211上，且加强筋8212沿径向间隔分布。当将滤芯820组装至壳体810内时，使滤芯820的一端伸入滤芯腔810a内，直至定位圆柱8211与定位台阶811相抵靠，完成组装，因此方便组装和拆卸。
请参阅图2，腔内热灌注循环管路10还包括出腔流量指示器600’，出腔流量指示器600’串接于回液管路104中。例如，本实施例中，出腔流量指示器600’串接于过滤器800的工位后方。出腔流量指示器600’的结构与入腔流量指示器600的结构基本相同。
具体地，出腔流量指示器600’包括底座610、叶轮620、透明盖体630及避光上盖640，底座610形成有叶轮腔610a，叶轮腔610a与回液管路104相连通。叶轮620通过转轴可转动地设置于底座610上，且位于叶轮腔610a内，透明盖体630设置在底座610上，用于密封叶轮腔610a，避光上盖830640可盖合地设置于底座610上，且能够覆盖在透明盖体630上。
底座610为避光材料制成，透明盖体630可以为透明材质制成，例如透明塑料或者透明玻璃等等。当液体进入叶轮腔610a时，由于液体的连续性，会冲刷叶轮620，叶轮620在流动的液体的作用下转动，通过透明盖体630观察叶轮620是否转动即可知晓液体是否处于流动状态。
叶轮620相对于叶轮腔610a偏心设置，以适应较低的流速。如当流量指示器应用到膀胱循环热灌注装置时，在进行治疗时，管路系统中的流速通常在50ml/min～200ml/min之间，大 多数情况下低于150ml/min，这样的速度相对来说是很慢的，因此需要增加叶轮620转动的灵敏度。
请参阅图2，腔内热灌注循环管路10还包括流量调节阀900，流量调节阀900串接于回液管路104中，例如，本实施方式中，流量调节阀900位于出去流量指示器的工位后方，流量调节阀900用于调节回液管路104中药液的流速。
具体地，进液管路101、出液管路102、预充管路103、入腔管路105、出腔管路106及回液管路104都可以采用由软质材料制成的软管。软管还可以具有避光性能，以满足膀胱化疗的某些药物需要避光进行的需求。
二通阀400、加药接头500、测压组件300、入腔流量指示器600、入腔测温器700、出腔测温器700’、过滤器800、出腔流量指示器600’及流量调节阀900均可以通过接头20与锁紧套30相配合的纯物理连接方式串接于管路系统中，防止粘接剂的残留。
具体地，接头20上形成有通道20a，液体通过通道20a与管路系统相连通。接头20包括配合段21及连接段22，配合段21的外侧壁上形成有第一凸起23，连接段22的外侧壁为圆锥面。锁紧套30包括第一锁紧段31及第二锁紧段32，第一锁紧段31的内侧壁上形成有与第一凸起23相配合的第二凸起33，第二锁紧段32的内侧壁突出形成有压紧部，软管被压紧在压紧部与连接段22之间。
当锁紧套30与接头相配合时，预先将锁紧套30套入软管内，然后将软管的一端套在接头的连接段22，软管越套入连接段22时，会被连接段22撑大。使锁紧套30移动，直到第一锁紧套30内侧壁的第二凸起33经过配合段21外侧壁的第一凸起23，而第二锁紧段32的内侧壁的压紧部会对软管有一定的压紧作用，因此可以将软管压紧在连接段22与第二锁紧段32之间，防止软管脱离接头。
上述腔内热灌注循环管路10至少具有以下优点：
将插针插入药液袋中，转动二通阀400的阀芯410，使二通阀400处于打开状态，药液袋中的药液经由进液管路101进入加热罐100的储液腔100a内，并可以通过加药接头500往进液管路101中注入化疗药物等等。当加热罐100中的药液量达到设定值时关闭二通阀400，进液管路101处于关闭状态，通过电磁感应加热装置对加热罐100内的药液进行预加热直到达到预热温度。
打开预充阀1031，关闭入腔阀1051及出腔阀1061，药液在循环泵200的作用下被抽取出储液腔100a，测压组件300外接测压传感器，对出液管路102中的液体的压力进行测量。药液经过出液管路102上的入腔流量指示器600、入腔测温器700后通入预充管路103内，再经由回液管路104上的出腔测温器700’、过滤器800、出腔流量指示器600’及流量调节阀900后回流至加热罐100中。药液经由出液管路102、预充管路103及回液管路104后流回加热罐100中，因此可以预先将管路系统中的空气排掉以避免引发炎症。
然后关闭预充阀1031，打开入腔阀1051及出腔阀1061，药液在循环泵200的作用下再次被抽取出储液腔100a，经由出液管路102、入腔管路105后进入膀胱中，然后从膀胱中流出，经由出腔管路106、回液管路104流回至加热罐100中。在药液循环的过程中，加热罐100可持续对药液进行加热，直到达到设定温度，达到边循环、边升温的目的，不至于一开始就使药液温度迅速升温，避免造成膀胱收缩或痉挛。
以上所述实施例仅表达了本发明的几种实施方式，其描述较为具体和详细，但并不能因此而理解为对发明专利范围的限制。应当指出的是，对于本领域的普通技术人员来说，在不脱离本发明构思的前提下，还可以做出若干变形和改进，这些都属于本发明的保护范围。因此，本发明专利的保护范围应以所附权利要求为准。

Claims (10)

  1. 一种腔内热灌注循环管路，其特征在于，包括：
    加热罐，呈中空状以形成储液腔，所述储液腔用于储存药液；
    进液管路，一端与所述储液腔相连通，另一端用于与药液袋相连通；
    出液管路，一端与所述储液腔相连通；
    循环泵，串接于所述出液管路中，用于将所述储液腔中的药液抽出；
    预充管路，一端与所述出液管路的另一端相连通；
    回液管路，一端与所述预充管路的另一端相连通，另一端与所述储液腔相连通；
    入腔管路，一端与所述出液管路的另一端相连通，另一端用于与体腔相连通；及
    出腔管路，一端用于与体腔相连通，另一端与所述回液管路的一端相连通，所述预充管路与所述入腔管路及所述出腔管路并联。
  2. 根据权利要求1所述的腔内热灌注循环管路，其特征在于，所述加热罐包括罐体及盖体，所述罐体呈中空状且一端开口形成开口端，所述盖体盖设于所述罐体的开口端，所述盖体与所述罐体共同围成所述储液腔，其中，所述罐体用于放置于电磁感应加热装置上，所述电磁感应加热装置用于加热所述罐体，以间接加热所述储液腔内的液体。
  3. 根据权利要求2所述的腔内热灌注循环管路，其特征在于，所述罐体包括罐壳及基座，所述基座设置于所述罐壳的底部，所述罐壳为塑料材质，所述基座为金属材质，所述基座与所述罐壳通过注塑方式一体成型；或者
    所述罐体整体为金属材质制成；或者
    所述罐体具有底部，所述底部远离所述开口端，所述罐体的底部为金属材质制成。
  4. 根据权利要求2所述的腔内热灌注循环管路，其特征在于，所述加热罐还包括空气过滤器及密封帽，所述盖体上形成有配合接头，所述空气过滤器通过所述配合接头与所述储液腔相连通，所述密封帽能够密封所述空气过滤器。
  5. 根据权利要求2所述的腔内热灌注循环管路，其特征在于，所述加热罐还包括第一测温组件，所述第一测温组件包括第一温度传感器及第一空心管，所述第一温度传感器具有第一探头端，所述第一探头端伸入所述第一空心管且位于所述第一空心管的端部，所述第一空心管的一端伸入所述储液腔中，且靠近所述罐体的底部设置。
  6. 根据权利要求1所述的腔内热灌注循环管路，其特征在于，还包括测压组件，所述测压组件串接于所述出液管路上，且位于所述循环泵的工位后方，所述测压组件用于测量所述循环泵的工位后方的出液管路内的压力。
  7. 根据权利要求6所述的腔内热灌注循环管路，其特征在于，所述测压组件包括测压延长管、测压阀及测压保护帽，所述测压延长管串接于所述出液管路上，且位于所述循环泵的工位后方，所述测压阀用于控制所述测压延长管的开闭，所述测压保护帽套设于所述测压延长管的一端。
  8. 根据权利要求1至7中任意一项所述的腔内热灌注循环管路，其特征在于，还包括：
    二通阀，串接于所述进液管路中，所述二通阀用于控制所述进液管路的开闭，所述二通阀包括阀本体，所述阀本体包括阀芯及阀体，所述阀芯上开设有通液孔，所述阀体至少一端开口且内部呈中空状以形成收容腔，所述阀体的侧壁上形成有与所述收容腔相连通的第一进液通道及第一出液通道，所述阀芯的一端伸入所述收容腔，且所述阀芯相对于所述阀体可转动，以使所述通液孔能够与所述第一进液通道及所述第一出液通道相连通或不连通；和/或
    加药接头，串接于所述进液管路中，所述加药接头包括加药管体、把手及保护翼板，所述加药管体的内部形成有输液通道，所述输液通道与所述进液管路相连通，所述加药管体的侧壁上形成有加药孔，所述加药孔与所述输液通道相连通，所述加药管体上设置有用于密封所述加药孔的加药软塞，所述把手设置于所述加药管体的外侧壁上，且与所述加药孔间隔设置，所述保护翼板设置于所述加药管体的外侧壁上，且位于所述加药孔与所述把手之间以形 成保护墙。
  9. 根据权利要求1至7中任意一项所述的腔内热灌注循环管路，其特征在于，还包括：
    入腔流量指示器，串接于所述出液管路中，所述入腔流量指示器包括底座、叶轮、透明盖体及避光上盖，所述底座形成有叶轮腔，所述叶轮腔与所述出液管路相连通，所述叶轮通过转轴可转动地设置于所述底座上，且位于所述叶轮腔内，所述透明盖体设置在所述底座上，用于密封所述叶轮腔，所述避光上盖可盖合地设置于所述底座上，且能够覆盖在所述透明盖体上；和/或
    入腔测温器，串接于所述出液管路中，所述入腔测温器包括第一储液壳体、第二测温组件、第一入腔端盖及第二入腔端盖，所述第一储液壳体内部呈中空状以形成第一储液室，所述第一储液室与所述出液管路相连通，所述第一储液壳体包括相对设置的第一小径端与第一大径端，所述第一小径端的内径小于所述第一大径端的内径，所述第二测温组件包括第二空心管及第二温度传感器，所述第二温度传感器具有第二探头端，所述第二探头端伸入所述第二空心管且位于所述第二空心管的端部，所述第一入腔端盖覆盖在所述第一储液壳体的第一大径端，所述第二入腔端盖设置在所述第一储液壳体的第一小径端，其中，所述第二空心管由所述第一入腔端盖伸入所述第一储液室内，且邻近于所述第二入腔端盖上的第一进液通孔。
  10. 根据权利要求1至7中任意一项所述的腔内热灌注循环管路，其特征在于，还包括以下中的一个或多个：
    出腔测温器，串接于所述回液管路中，所述出腔测温器包括第二储液壳体、第三测温组件、第一出腔端盖及第二出腔端盖，所述第二储液壳体内部呈中空状以形成第二储液室，所述第二储液室与所述回液管路相连通，所述第二储液壳体包括相对设置的第二小径端与第二大径端，所述第二小径端的内径小于所述第二大径端的内径，所述第三测温组件包括第三空心管及第三温度传感器，所述第三温度传感器具有第三探头端，所述第三探头端伸入所述第三空心管且位于所述第三空心管的端部，所述第一出腔端盖覆盖在所述第二储液壳体的第二大径端，所述第二出腔端盖设置在所述第二储液壳体的第二小径端，其中，所述第三空心管由所述第一出腔端盖伸入所述第二储液室内，且邻近于所述第二出腔端盖上的第二进液通孔；
    过滤器，串接于所述回液管路中，所述过滤器包括壳体、滤芯、上盖及下盖，所述壳体形成有滤芯腔，所述滤芯腔与所述回液管路相连通，所述滤芯收容于所述滤芯腔内，所述滤芯用于过滤药液，所述上盖设置于所述壳体的一端，所述下盖设置于所述壳体的另一端；
    出腔流量指示器，串接于所述回液管路中，所述出腔流量指示器包括底座、叶轮、透明盖体及避光上盖，所述底座形成有叶轮腔，所述叶轮腔与所述回液管路相连通，所述叶轮通过转轴可转动地设置于所述底座上，且位于所述叶轮腔内，所述透明盖体设置在所述底座上，用于密封所述叶轮腔，所述避光上盖可盖合地设置于所述底座上，且能够覆盖在所述透明盖体上；
    流量调节阀，串接于所述回液管路中，所述流量调节阀用于调节所述回液管路中药液的流速。
PCT/CN2018/097599 2018-04-28 2018-07-27 腔内热灌注循环管路 WO2019205326A1 (zh)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US16/954,017 US11406770B2 (en) 2018-04-28 2018-07-27 Circulation pipeline for intracavity hyperthermic perfusion
EP18915831.4A EP3708131A4 (en) 2018-04-28 2018-07-27 CIRCULATION LINE FOR INTRACAVITY HYPERTHMIC INFUSION
AU2018421233A AU2018421233B2 (en) 2018-04-28 2018-07-27 Circulation pipeline for intracavity hyperthermic perfusion

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810401888.8 2018-04-28
CN201810401888.8A CN108371582B (zh) 2018-04-28 2018-04-28 腔内热灌注循环管路

Publications (1)

Publication Number Publication Date
WO2019205326A1 true WO2019205326A1 (zh) 2019-10-31

Family

ID=63033003

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/097599 WO2019205326A1 (zh) 2018-04-28 2018-07-27 腔内热灌注循环管路

Country Status (5)

Country Link
US (1) US11406770B2 (zh)
EP (1) EP3708131A4 (zh)
CN (3) CN117562736A (zh)
AU (1) AU2018421233B2 (zh)
WO (1) WO2019205326A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110393627A (zh) * 2019-08-29 2019-11-01 吉林省迈达医疗器械股份有限公司 一种用于腹腔的热化疗灌注机
CN112156261A (zh) * 2020-10-15 2021-01-01 尹国英 一种高效妇科临床用阴道清洗装置
CN113893112A (zh) * 2021-09-23 2022-01-07 海南医学院第一附属医院 一种肿瘤内科的多功能化疗控制装置
CN115317234B (zh) * 2022-07-21 2023-07-18 河南中栋医疗科技有限公司 一种腔内热灌注药循环管路系统
CN116216902B (zh) * 2023-03-15 2024-04-19 河北惠尔信新材料股份有限公司 一种污水处理用中和剂定量添加设备

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000296146A (ja) * 1999-04-16 2000-10-24 Olympus Optical Co Ltd 腹腔内灌流加温装置
CN202313910U (zh) * 2011-08-04 2012-07-11 北京利康达科技有限公司 腔内肿瘤热灌注治疗系统
CN203954449U (zh) * 2014-06-04 2014-11-26 广州保瑞医疗技术有限公司 一种膀胱热灌注治疗仪
CN205084071U (zh) * 2015-09-21 2016-03-16 广州保瑞医疗技术有限公司 体腔热灌注导管设备
CN105727426A (zh) * 2016-01-22 2016-07-06 深圳迈地海特科技有限公司 体腔热灌注循环装置
CN108836618A (zh) * 2018-04-28 2018-11-20 广州保瑞医疗技术有限公司 腔内循环热灌注装置

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4263372B2 (ja) * 1999-05-25 2009-05-13 バイアサーク・インコーポレイテッド 温熱処置方法並びに装置
CN202892196U (zh) * 2012-02-14 2013-04-24 刘凤珍 一种腔内热灌注化疗系统
CN202875910U (zh) * 2012-09-06 2013-04-17 王学礼 体外循环管
CN102899250B (zh) * 2012-10-22 2014-12-03 湖南大学 用于组织工程的可控液压生物反应器
US9302091B2 (en) * 2013-07-12 2016-04-05 Carefusion 303, Inc. Check valve system
CN204261104U (zh) * 2014-11-26 2015-04-15 李唯 一种多频多点加热装置
CN208808826U (zh) * 2018-04-28 2019-05-03 广州保瑞医疗技术有限公司 腔内热灌注循环管路

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000296146A (ja) * 1999-04-16 2000-10-24 Olympus Optical Co Ltd 腹腔内灌流加温装置
CN202313910U (zh) * 2011-08-04 2012-07-11 北京利康达科技有限公司 腔内肿瘤热灌注治疗系统
CN203954449U (zh) * 2014-06-04 2014-11-26 广州保瑞医疗技术有限公司 一种膀胱热灌注治疗仪
CN205084071U (zh) * 2015-09-21 2016-03-16 广州保瑞医疗技术有限公司 体腔热灌注导管设备
CN105727426A (zh) * 2016-01-22 2016-07-06 深圳迈地海特科技有限公司 体腔热灌注循环装置
CN108836618A (zh) * 2018-04-28 2018-11-20 广州保瑞医疗技术有限公司 腔内循环热灌注装置

Also Published As

Publication number Publication date
EP3708131A4 (en) 2021-06-09
US11406770B2 (en) 2022-08-09
EP3708131A1 (en) 2020-09-16
AU2018421233A1 (en) 2020-07-02
CN108371582B (zh) 2023-11-10
CN117562736A (zh) 2024-02-20
US20210077749A1 (en) 2021-03-18
CN108371582A (zh) 2018-08-07
CN117562735A (zh) 2024-02-20
AU2018421233B2 (en) 2022-02-03

Similar Documents

Publication Publication Date Title
WO2019205326A1 (zh) 腔内热灌注循环管路
WO2019205327A1 (zh) 腔内循环热灌注装置
US7819835B2 (en) Hyperthermia, system, method and components
CN107174338B (zh) 医疗装置冷却系统和用于冷却医疗消融装置的系统
US20180333295A1 (en) Hyperthermia, system, method and components
RU2662075C1 (ru) Циркуляционная трубопроводная система с обеспечением теплового баланса
EP2654861B1 (en) Fluid circulation system
CN1326580C (zh) 红外热灌注治疗仪
CN208808826U (zh) 腔内热灌注循环管路
EP3306290A1 (en) An assembly and the related method for measuring the temperature of a fluid for hyperthermic treatment of a body cavity
CN2538343Y (zh) 微波热灌注循环治疗机
CN209137069U (zh) 腔内循环热灌注装置
CN113577427A (zh) 智能控压给药灌肠器及其使用方法
CN107569728B (zh) 一种热灌注直接测温引流管套件
CN212327086U (zh) 一种消化内科用灌肠器
CN208989840U (zh) 一种中药保温灌肠器
CN209019733U (zh) 用于中药液自动给药的滴入仪
CN213789240U (zh) 一种消化内科护理用灌肠器
CN219662460U (zh) 一种可控温的灌肠袋
CN108211058A (zh) 一种输液导管的加热装置
CN209751795U (zh) 一种消化内科用灌肠装置
CN105311696B (zh) 新型灌肠器

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18915831

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2018915831

Country of ref document: EP

Effective date: 20200609

ENP Entry into the national phase

Ref document number: 2018421233

Country of ref document: AU

Date of ref document: 20180727

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE