WO2019196733A1 - Procédé de mesure de contenu de composant sanguin d'un corps humain, et dispositif associé - Google Patents

Procédé de mesure de contenu de composant sanguin d'un corps humain, et dispositif associé Download PDF

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Publication number
WO2019196733A1
WO2019196733A1 PCT/CN2019/081454 CN2019081454W WO2019196733A1 WO 2019196733 A1 WO2019196733 A1 WO 2019196733A1 CN 2019081454 W CN2019081454 W CN 2019081454W WO 2019196733 A1 WO2019196733 A1 WO 2019196733A1
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WIPO (PCT)
Prior art keywords
temperature
signal
tested
human body
heat generating
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PCT/CN2019/081454
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English (en)
Chinese (zh)
Inventor
陈兴明
张跃
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澳菲科技（深圳）有限公司
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Publication of WO2019196733A1 publication Critical patent/WO2019196733A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1491—Heated applicators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/01—Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
    • A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
    • A61B5/6844—Monitoring or controlling distance between sensor and tissue

Definitions

  • the present application relates to the technical field of blood component content measurement, and in particular to a method and device for measuring blood component content of a human body.
  • the blood components of human blood such as blood sugar, blood uric acid, triglycerides, cholesterol and biomarkers, are obtained by invasive acupuncture to obtain blood samples, and then the blood samples obtained are detected by a special medical detector. obtain.
  • the drawback is that the needle-punching skin will cause some pain to the subject, and the related specialized medical detector is expensive.
  • Comparative Document 1 discloses a non-invasive blood glucose measuring method comprising: determining a current absorption rate B1 of the predetermined portion to infrared light having a wavelength of ⁇ 1, and then measuring the infrared light of the predetermined portion to a wavelength of ⁇ 2.
  • the current absorption rate B2 according to B1, B2 and the pre-stored initial blood glucose concentration value A0, the initial absorption rate A1 of the infrared light of the predetermined portion to the wavelength ⁇ 1, and the initial absorption rate A2 of the infrared light of the predetermined portion to the wavelength ⁇ 2
  • the current blood glucose concentration value D0 A0 ⁇ (B1-B2)/(A1-A2)+k; where k is a constant and 0 ⁇ k ⁇ 0.5.
  • the non-invasive blood glucose measurement method of Comparative Document 1 uses two different wavelengths of infrared light, and the same part is measured successively. The determination of the k value is complicated and inaccurate, and the physiological changes of the same part at different times are not considered, and the parameters are more. The error in the process of obtaining each parameter is unavoidable, and finally the accumulation of error will affect the detection result of blood glucose concentration.
  • the purpose of the embodiments of the present application is to provide a method and a device for accurately measuring the blood component content of a human body by using a human blood component to absorb the infrared light of a specific frequency by a non-invasive means.
  • the technical solution adopted by the present invention is:
  • the method for measuring the blood component content of the human body of the present invention has the following steps:
  • Infrared light having an absorption rate to a component to be tested in human blood is used as a detection signal to illuminate the portion to be tested;
  • the temperature corresponding to the at least two different temperatures is an increasing, decreasing, or increasing or decreasing alternating.
  • the distance between the signal receiver and the surface of the human body is adjusted to a feedback signal received by the signal receiver at a set standard luminous flux range.
  • the temperature corresponding to the detection of the part to be tested is in the range of 3 to 5, wherein the temperature corresponding to each level is the first temperature, the second temperature or the third temperature, wherein the second temperature is 1 to 50 lower than the first temperature. °C, the third temperature is 1 to 50 ° C higher than the first temperature.
  • the device for accurately measuring the blood component content of a human body comprises a main control circuit and a signal generator capable of emitting infrared light as a detection signal, wherein the measuring device is further provided with an accurate illumination of the detection signal.
  • a positioning device for a portion to be tested on a person a signal receiver for receiving a feedback signal, and a temperature adjusting device, wherein the feedback signal is a remaining amount of the detection signal that is not absorbed by the portion to be tested and emitted outside the body.
  • the adjusting device comprises a heat generating component that transfers thermal energy by means of heat radiation or heat conduction to the portion to be tested, a temperature change of the temperature of the heat generating component, and a thermal energy regulator controlled by the main control circuit, and the heat is collected in real time.
  • a temperature of the component and a temperature electrical signal corresponding to the temperature is transmitted to the first temperature sensor of the main control circuit and a heat sink that can quickly discharge thermal energy of the thermal energy regulator to the surrounding space, wherein the heat generating component is placed Near the portion to be tested, a thermal energy regulator is placed between the heat generating component and the heat sink.
  • the signal receiver can be moved toward or away from the portion to be tested along the direction of the feedback signal under the driving of the manual adjustment mechanism or the micro motor.
  • a second temperature sensor is disposed in the vicinity of the signal receiver; when the signal generator and the signal receiver are disposed on the same side of the to-be-measured portion, the second temperature sensor may The temperature is transmitted to the main control circuit and the temperature of the heat generating component is adjusted to a set value by the main control circuit through the thermal energy regulator; when the signal generator, the portion to be tested and the signal When the geometric center of the receiver is on the same straight line and the portion to be tested is between the signal generator and the signal receiver, the second temperature sensor can transmit the temperature of the feedback signal to the body part to the main And controlling, by the main control circuit, the temperature of the heat generating component to a set value in real time through the thermal energy regulator.
  • the heat generating component, the thermal energy adjuster, the signal generator, and the heat sink are fastened into a unitary structure, wherein
  • the heat-generating component is a hemispherical circle, and a light-passing hole is arranged along the axial direction thereof, and the spherical crown is facing outward;
  • the thermal energy regulator is a semiconductor heating sheet with a central through hole and a disk shape
  • the heat sink is a columnar metal heat conducting member having an axial hollow passage
  • a front end of the signal generator is placed in the light passage through the axial hollow passage and the central through hole.
  • An anti-scalding diaphragm having a thermal resistance is provided on the spherical cap of the heat generating component.
  • the heat generating component, the thermal energy adjuster, the signal generator, and the heat sink are fastened into a unitary structure, wherein
  • the heat-generating component has a hemispherical circle shape, and the spherical crown of the heat-generating component faces outward, and a plurality of light-passing holes are provided from the spherical crown to the bottom surface of the heat-generating component, and a pinch between the axes of the plurality of light-passing holes Angle into an acute angle;
  • the thermal energy regulator is a semiconductor heating sheet having the same number of through holes as the light passing holes and having a disk shape;
  • the heat sink is a columnar metal heat conducting member having an axial hollow passage
  • the signal generator is an infrared light generator of a multi-head illuminator, and a front end of each head illuminator is disposed in the corresponding light-passing aperture through the axial hollow passage and a corresponding through hole.
  • the method of the invention provides a new idea for medical researchers to accurately know the blood component content of the human body through non-invasive detection, and opens up a precedent for detecting human blood components by using infrared multi-spectral technology, which can be used for medical research institutions on human blood components.
  • infrared multi-spectral characteristics of biomarkers of cancer are studied to provide a powerful help for humans to accurately prevent major diseases.
  • the measuring device of the present invention is non-invasive, which has the following advantages:
  • FIG. 1 is a schematic view of a device for measuring a blood component content of a human body in a device for measuring a blood component of a human body according to an embodiment of the present invention
  • FIG. 2 is a partial enlarged view of a device for measuring a blood component of a human body in an apparatus for measuring a blood component content of a human body according to an embodiment of the present invention
  • FIG. 3 is a schematic view showing an explosion of a device corresponding to a tiger mouth portion of a device for measuring a blood component content of a human body according to an embodiment of the present invention
  • FIG. 4 is a partial enlarged view of a schematic diagram of an apparatus for measuring a blood component of a human body according to an embodiment of the present invention, which is applied to a device corresponding to a tiger's mouth;
  • FIG. 5 is an exploded perspective view of a heat generating component and a thermal energy regulator in an apparatus for measuring a blood component content of a human body according to an embodiment of the present invention
  • Figure 6 is a schematic view showing a heat generating component of a dual signal path in a device for measuring a blood component content of a human body according to another embodiment of the present invention
  • Fig. 7 is a flow chart showing a method for measuring the blood component content of a human body according to an embodiment of the present invention.
  • Main control circuit 1 signal generator 2, temperature adjusting device 3, heat generating component 31, light passing hole 311, notch 312, thermal energy regulator 32, through hole 321, heat sink 33, axial hollow channel 331, temperature control signal acquisition
  • the module 4 the first temperature sensor 41, the second temperature sensor 42, the positioning device 5, the housing portion 51, the first housing chamber 511, the second housing chamber 512, the top cover portion 52, the receiving hole 521, the observation hole 522, and the binding Belt 6, hand 7, signal receiver 8.
  • the present application relates to a method for measuring the blood component content of a human body by a non-invasive means, which refers to blood components including blood sugar, blood uric acid, triglyceride, cholesterol, creatinine or biomarkers in human blood.
  • a non-invasive means refers to blood components including blood sugar, blood uric acid, triglyceride, cholesterol, creatinine or biomarkers in human blood.
  • a device for measuring blood component content of a human body can realize non-invasive detection of blood component content of a human body.
  • the measuring device is composed of a main control circuit 1, a signal generator 2, a signal receiver 8, a temperature adjusting device 3, a temperature control signal collecting module 4, and a positioning device 5.
  • the main control circuit 1 includes a microprocessor, a data memory, a PWM pulse width modulation module, an A/D conversion module, a start or stop signal generator 2, a signal receiver 8 and a switching circuit for operating the temperature adjustment device 3.
  • the main control circuit 1 is used to perform the following operations:
  • the control signal generator 2 emits an infrared light detection signal of a specific frequency
  • the feedback signal is the remaining amount of the detection signal that is not absorbed by the blood component to be tested and emitted outside the body
  • the feedback signal is the remaining amount of the detection signal that is not absorbed by the blood component to be tested and emitted outside the body
  • the temperature adjusting device 3 is controlled to heat or cool and stabilize the temperature adjusting device 3 at a set temperature to ensure that the temperature of a certain portion to be tested of the human body is in a controlled state.
  • the part to be tested may be selected in the tiger's mouth part, the neck part, the ankle part, the ear part, the nostril, the armpit, the arm part or the lower limb part of the hand part 7 as mentioned above, and may also be selected in the easy to obtain feedback signal.
  • Body parts may be selected in the tiger's mouth part, the neck part, the ankle part, the ear part, the nostril, the armpit, the arm part or the lower limb part of the hand part 7 as mentioned above, and may also be selected in the easy to obtain feedback signal.
  • Body parts may be selected in the tiger's mouth part, the neck part, the ankle part, the ear part, the nostril, the armpit, the arm part or the lower limb part of the hand part 7 as mentioned above, and may also be selected in the easy to obtain feedback signal.
  • the signal generator 2 is configured to be controlled by the PWM pulse width modulation module to generate a detection signal of infrared light of a desired frequency or frequency range.
  • the characteristic is that the frequency range of the detected signal is set in the frequency-specific area corresponding to the blood component to be tested (the specific area refers to the frequency range corresponding to the blood component of the blood to be measured in the peak state of infrared light absorption).
  • the signal generator 2 can be either direct type or reflective type (direct type refers to the light-emitting tube and the receiving tube are relatively placed at opposite ends of the emission and the controlled object, and the distance between them is at a certain distance; the reflective type refers to the side of the light-emitting tube and the receiving tube.
  • direct type refers to the light-emitting tube and the receiving tube are relatively placed at opposite ends of the emission and the controlled object, and the distance between them is at a certain distance
  • the reflective type refers to the side of the light-emitting tube and the receiving tube.
  • the receiving tube always has no light, and only when the infrared light emitted by the luminous tube encounters the reflector, the receiving tube receives the reflected infrared light to work), and can also be a multi-tube infrared transmitting circuit to increase the transmitting power. Increase the range of the infrared emission.
  • a condensing lens is further provided at the front end of the arc tube in the signal generator 2.
  • the infrared light generated by the signal generator 2 is accurately irradiated to the portion to be tested.
  • the signal receiver 8 may be of a direct receiving type or a reflective receiving type, which sends the received feedback signal to the microprocessor for analysis processing.
  • the preferred installation manner of the present invention is that the signal receiver 8 can be moved by a short distance under the driving of a manual adjustment mechanism or a micro motor, and the direction of the movement is opposite or opposite to the portion to be tested along the direction of the feedback signal. Reciprocating.
  • the temperature regulating device 3 is configured to transfer thermal energy to the portion to be tested by thermal radiation and/or heat conduction, the purpose of which is to promote the temperature of the portion to be tested to continuously rise or fall or maintain a constant range within a certain range, and maintain a constant time of 0.2. -10 minutes.
  • the temperature adjustment device 3 is an integrated structure for temperature rise and temperature reduction, that is, heating is required when the temperature is raised, and it is required to be cooled when the temperature is lowered.
  • the preferred component is a semiconductor heating sheet.
  • Heating or cooling is required, on time, in rhythm (the rhythm means: continuous heating or continuous cooling, or heating and cooling alternately).
  • the preferred temperature regulating device 3 of the present invention has the following structure:
  • the heat generating component 31 is composed of a heat generating component 31, a thermal energy regulator 32, and a heat sink 33 for transferring heat of its own heat to the portion to be tested by heat conduction, the heat generating component 31 being made of a material having good heat conductivity. Including and not limited to copper, aluminum, silver, low carbon steel, stainless steel or alloy materials thereof.
  • the heat generating component 31 can be in contact with the portion to be tested and continuously set a time to balance the temperature of the portion to be tested with the actual temperature of the heat generating component 31.
  • the shape of the heat generating component 31 may be a conical shape having a hole or an opening, a rhombic shape, a truncated cone shape, an ellipsoidal shape, a semi-conical shape, a semi-diamond shape, a semi-circular shape, a semi-ellipsoidal shape or a sheet shape.
  • the present invention preferably has a hole-shaped spherical shape.
  • a diaphragm for preventing burns may be disposed on the outer surface of the heat generating component 31, and the diaphragm has a certain thermal resistance.
  • the thermal energy regulator 32 is configured to generate a thermal energy change under the control of the main control circuit 1 and transmit the thermal energy change to the heat generating component 31 by conduction to cause the temperature of the heat generating component 31 to increase or decrease the temperature.
  • the thermal energy regulator 32 may be a semiconductor heating sheet, a resistive heating sheet, an infrared heating sheet or the like, and has a shape of a circular shape, a semicircular shape, a square shape, an elliptical shape, a triangular shape, a through hole 321 or an opening.
  • the preferred structure of the present invention is a sheet-shaped semiconductor heating sheet which can be heated or refrigerated, and is characterized in that when the current flowing therein is a forward flow, the front surface of the semiconductor heating sheet releases heat outward. Backside cooling; when the current to it flows in the opposite direction, its front side cools and the back side releases heat.
  • the heat sink 33 is for assisting the thermal energy regulator 32 to quickly dissipate the heat energy generated on the back surface to the surrounding space when the front surface of the thermal energy regulator 32 cools the heat generating component 31.
  • the shape may be cylindrical, fin-shaped or needle-shaped.
  • It can be made of copper, aluminum or copper alloy, aluminum alloy or other materials with good thermal conductivity.
  • the present invention can assemble the signal generator 2, the heat generating component 31, the thermal energy regulator 32 and the heat sink 33 into components that integrate or achieve the same function.
  • the present invention preferably employs an integrated structure temperature regulating and signal generating device application. In the measuring device.
  • the temperature adjustment and signal generating device of the integrated structure is preferably in the following two ways:
  • the heat generating component 31 is a hemispherical circle, and a light passage hole 311 is provided along the axial direction thereof, and the spherical crown is outward.
  • the thermal energy regulator 32 is a semiconductor heating sheet having a central through hole 321 and having a disk shape.
  • the heat sink 33 has a copper columnar shape and has an axial hollow passage 331.
  • the light passage hole 311, the central through hole 321 and the axial hollow passage 331 are disposed coaxially.
  • the signal generator 2 adopts a single-head LED light-emitting tube, and its front end is placed in the light-passing hole 311 through the axial passage and the central through hole 321 at the bottom of the heat sink 33, and the light-passing hole 311 is a signal generation.
  • the transmitter 2 transmits a signal path of the detection signal.
  • the heat generating component 31 of this structure has the following advantages:
  • the detection signal When the heat generating component 31 is in contact with the portion to be tested, the detection signal is transmitted through the light tunnel 311. On the one hand, the detection signal does not become weak during transmission, and on the other hand, it is not interfered by external signals, thereby detecting blood components. When ensuring the stability of the detection signal;
  • the obtained feedback signal is weak, it is advantageous to capture the change information of the concentration of the blood component
  • the structure is simple, and no complicated structural design is required to ensure the stability of the detection signal.
  • connection structure is such that the bottom surface of the spherical cap of the heat generating component 31 is in contact with the front surface of the semiconductor heating sheet, the back surface of the semiconductor heating sheet is in contact with the cylindrical top surface of the heat sink 33, and between the heat generating component 31, the semiconductor heating sheet and the heat sink 33. It is preferably connected by a quick fastening structure (such as a snap-fit, male snap or screw connection), and the contact surface is preferably provided with thermal grease.
  • a quick fastening structure such as a snap-fit, male snap or screw connection
  • the heat generating component 31 is a hemispherical circle with its spherical crown facing outward, and there may be a plurality of light passage holes 311 from its spherical crown to its bottom surface (see Fig. 6).
  • the heat sink 33 has a copper column shape and has an axial hollow passage 331.
  • the light passing holes 311 are opposite to the corresponding through holes 321 .
  • the signal generator 2 is an infrared light emitting tube.
  • the front end of the light emitting tube is placed in the corresponding light passing hole 311 through the axial hollow channel 331 and the corresponding through hole 321 through the bottom of the heat sink 33.
  • a condensing convex lens is disposed on the front end surface of the heat generating component 31, thereby concentrating the infrared light detecting signals emitted from the plurality of LED light emitting tubes at the portion to be tested. It improves the signal strength of the detection signal and avoids the problem that the detection signal becomes weak during transmission.
  • connection structure is such that the bottom surface of the spherical cap of the heat generating component 31 is in contact with the front surface of the semiconductor heating sheet, the back surface of the semiconductor heating sheet is in contact with the cylindrical top surface of the heat sink 33, and between the heat generating component 31, the semiconductor heating sheet and the heat sink 33. It is preferably connected by a quick fastening structure (such as a snap-fit, male snap or screw connection), and the contact surface is preferably provided with thermal grease.
  • a quick fastening structure such as a snap-fit, male snap or screw connection
  • the temperature control signal acquisition module 4 is configured to timely collect and transmit the temperature signal of the portion or component requiring temperature monitoring in the measuring device of the present invention to the main control circuit 1.
  • the present invention preferably monitors two temperature signals in real time. One is the temperature of the heat generating component 31, and the other is the temperature of the portion to be tested.
  • the sensor for collecting the temperature signal of the heat generating component 31 is a first temperature sensor 41 disposed in the vicinity of the heat generating component 31, which can transmit the temperature signal to the main control circuit 1 in real time, and is set by the main control circuit 1 according to the setting. It is required to control the temperature regulating device 3 (the first temperature sensor 41 can be assigned to one of the components of the temperature adjusting device 3).
  • the sensor for collecting the temperature signal of the portion to be tested is the second temperature sensor 42, which is placed in the vicinity of the signal receiver 8.
  • the second temperature sensor 42 can transmit the temperature of the portion to be tested to the The main control circuit 1 and the main control circuit 1 adjust the temperature of the heat generating component 31 to a set value in real time through the thermal energy regulator 32.
  • the second temperature sensor 42 can transmit the temperature of the feedback signal to the body part to the main control circuit 1 and adjust the real-time adjustment by the main control circuit 1 through the thermal energy regulator 32.
  • the temperature of the heat generating component 31 is set to a value.
  • the temperature sensor may include, but is not limited to, a bimetal thermometer sensor, a pressure thermometer sensor, a resistance thermometer sensor, a thermistor temperature sensor, a thermocouple temperature sensor, and an infrared temperature sensor.
  • a non-contact infrared temperature sensor is preferably used in the present invention.
  • the positioning device 5 is an ergonomically manufactured plastic casing by an injection molding process, or an ergonomically supported support frame made of a rigid material.
  • the function is to carry the main control circuit 1, the signal generator 2, the signal receiver 8, the temperature adjustment device 3 and the temperature control signal acquisition module 4, and to accurately irradiate the detection signal emitted by the signal generator 2
  • the temperature adjustment device 3 is also required to stably exchange thermal energy with the portion to be tested according to the design flow.
  • the measuring device of the present invention will be described in detail by taking the portion to be tested as the hand 7 portion of the hand.
  • the measuring device is provided by a casing into which the human hand 7 can be placed, the main control circuit 1, the signal generator 2, the signal receiver 8, the temperature adjusting device 3, and the temperature control signal collection.
  • Module 4 is constructed.
  • the outer casing is made of a plastic material by one injection molding, and is divided into a casing portion 51 and a top cover portion 52.
  • a first accommodating cavity 511 into which the palm portion of the palm is inserted, a second accommodating cavity 512 into which the thumb of the hand is placed, and the temperature adjusting device 3 are placed therein are respectively disposed on the housing portion 51. And a mounting position located at an upper position of the housing portion 51 and a slot, a hole or a card slot for fixing the temperature control signal acquisition module 4 and the main control circuit 1.
  • the palm is vertically inserted into the first accommodating cavity 511 in such a manner that the first accommodating cavity 511 and the second accommodating cavity form a "Y" shape, that is, a certain angle is formed.
  • a measuring portion that is, a mounting position at which the temperature adjusting device 3 is mounted, is formed at the intersection of the first accommodating chamber 511 and the second accommodating chamber 512.
  • top cover portion 52 is movably coupled to the housing portion 51 by a hinge structure, and a magnetic attraction assembly is disposed between the other side of the top cover portion 52 and the upper end edge of the corresponding side housing portion 51.
  • the hand When the detection is required, the hand is placed in the first accommodating cavity 511 and the second accommodating cavity 512, and the top cover portion 52 is sucked on the casing portion 51.
  • the casing portion When testing, the casing portion is supplemented by the strap 6 51 is fixed to the top cover portion 52.
  • the top cover portion 52 is provided with a receiving hole 521 for accommodating the signal receiver 8. Furthermore, a crimping plate and an observation opening 522 are provided, which are used to fix the wires of the measuring device.
  • the observation hole 522 is used to observe the inside of the first accommodating cavity 511 and the second accommodating cavity 512, and the observation hole 522 is plugged with a sealing plug when not in use.
  • a side cover of the main control circuit 1 is further provided with a cover to seal the main control circuit 1.
  • the invention cooperates with the heat generating component 31, the first temperature sensor 41 and the energy regulator, and when the heat generating component 31 is in contact with the portion to be tested, the blood component is not affected by the external temperature change, and the detection signal can be ensured.
  • the stability of the blood component can be accurately and reliably detected.
  • the temperature adjustment and signal generating device of the integrated structure is mounted on the mounting position, wherein the heat generating component 31 is disposed adjacent to the tiger's mouth, and the detection signal of the infrared light generated by the signal generator 2 is irradiated through the light passing hole 311 on the heat generating component 31.
  • the heat generating component 31 is disposed adjacent to the tiger's mouth, and the detection signal of the infrared light generated by the signal generator 2 is irradiated through the light passing hole 311 on the heat generating component 31.
  • the detection signal of the infrared light generated by the signal generator 2 is irradiated through the light passing hole 311 on the heat generating component 31.
  • a notch 312 is provided at the edge of the heat generating component 31, and the first temperature sensor 41 is inserted into the notch 312.
  • the signal receiver 8 is mounted on the inner face of the top cover portion 52 and placed on the opposite side of the mounting position.
  • the second sensor is mounted in the vicinity of the signal receiver 8.
  • the working principle is: after the hand is inserted into the first accommodating cavity 511 and the second accommodating cavity 512, the measuring device is activated, and the second temperature sensor 42 detects the temperature of the part to be tested (ie, the tiger's mouth).
  • the energy regulator transmits heat to the portion to be tested through the heat generating component 31, so that the temperature of the portion to be tested rises to the preset temperature;
  • the energy regulator cools to cause the heat generating component 31 to absorb heat of the portion to be tested, and the temperature of the portion to be tested is lowered to the preset a temperature;
  • the main control circuit 1 controls the signal generator 2 to emit a detection signal, and the feedback signal after the detection signal passes through the portion to be tested is
  • the signal receiver 8 receives and converts into an electrical signal, and the signal processor sent to the main control circuit 1 calculates the body
  • a method for measuring the blood component content of a human body includes the following steps as shown in FIG. 7:
  • Step S101 Select a part to be tested on the body of the person.
  • the part to be tested may be selected according to the degree of capillary intensiveness or the degree of blood flow protrusion, such as the tiger's mouth part of the hand, the neck, the ankle, the ear, the nostril, the armpit, the arm or the lower limb, etc.
  • a part of the human body that is easy to obtain a feedback signal is selected, which is a portion of the detection signal that is injected into the human body and then emitted from the body.
  • Step S102 temperature-adjusting the portion to be tested by using heat radiation and/or heat-conducting heat-generating component 31.
  • Step S103 illuminating the portion to be tested by using infrared light having an absorption rate of a component to be tested in human blood as a detection signal.
  • Infrared light of a specific frequency range is used as a detection signal to illuminate a selected portion to be tested.
  • the idea is based on the fact that the substances in the human body have different absorption of infrared light signals at different frequencies.
  • the specific frequency range refers to a frequency range of infrared light corresponding to the peak blood absorption rate (hereinafter referred to as specificity) of the blood component to be measured.
  • specificity the peak blood absorption rate of the blood component to be measured.
  • infrared light of a certain frequency range in which the blood glucose absorption rate is peaked is selected as a detection signal for detecting a blood sugar component to illuminate the portion to be tested, so that infrared light of the frequency range is only specific for the blood sugar component, and Other blood components (such as blood uric acid, etc.) exhibit a lower absorption rate or a constant absorption rate at different temperatures.
  • the difference in the absorption rate of the detection signal by different blood components is fully exhibited.
  • the absorption rate of infrared light by water shows a peak near the wavelength of 1400-1700 nm
  • the absorption rate of uric acid to infrared light shows a peak near the wavelength of 1300-1600 nm.
  • the frequency range corresponding to the absorption of infrared light by a certain blood component is called a peak range. It is a specific area.
  • the basic principle is: when a beam of infrared light with a continuous wavelength passes through a substance, the vibration frequency or rotation frequency of a certain group in the material molecule is the same as the frequency of the infrared light, the molecule absorbs energy from the original ground state vibration (rotation) kinetic energy. The stage transitions to the higher energy vibration (rotation) kinetic energy level, and the molecules absorb the infrared radiation and then vibrate or rotate the energy level.
  • the wavelength of the light is absorbed by the material, and the macroscopic expression is that the transmitted light intensity becomes smaller.
  • Step S104 Acquire a feedback signal by setting the signal receiver 8 outside the body.
  • the feedback signal is the remaining amount of the detection signal that is not absorbed by the portion to be tested and is emitted outside the body.
  • the feedback signal can be a penetration signal that directly detects the signal and passes through the human body, and can also be a reflection signal that is reflected after the detection signal enters the human body.
  • feedback signal detection signal [1 - (absorption ratio of component to be tested + absorption rate of other components)], wherein other components include other blood components and fat having a fixed absorption rate.
  • Step S105 When the part to be tested is at at least two different temperatures, respectively obtain the feedback signal at the corresponding temperature, and calculate the content of the component to be tested in the blood.
  • the molecular velocity of the same blood component at the temperature corresponding to the site to be tested is different.
  • the molecular rate of the blood component to be tested it accelerates and amplifies the absorption rate of the detection signal in a specific frequency range per unit time, without the absorption of the detection signal of the specific frequency range by other blood components in the specific region. The rate does not change or does not change much.
  • the characteristic curve of the absorption rate per unit time will be different at different temperatures. According to the characteristic curve and different temperatures, the concentration of the blood component to be tested is calculated.
  • obtaining the feedback signal at different temperatures and calculating the content of the component to be tested in the blood can be calculated according to the following formula:
  • y 1 and y 2 are the feedback signal receiving values at temperatures t 1 and t 2 (in the actual measurement, the voltage signal is in mv);
  • m is the content of the substance to be tested for blood components
  • f(t 1 ) and f(t 2 ) are the absorption functions of the unit substance to be detected by the human body, and f(t 1 ) and f(t 2 ) can be measured by establishing a mathematical model;
  • k 1 and k 2 are constants, and t 1 and t 2 are temperature values corresponding to the parts to be tested at different grades;
  • the content of the blood component to be tested in the human body is measured by measuring the specific absorption characteristics of the respective blood components.
  • the signal generator 2 emits an infrared light detecting signal having a wavelength of 1400 nm to 1700 nm; when it is required to measure the content of uric acid in the human body, the emitted wavelength is 1400 nm to 2700 nm. Infrared light detection signal to achieve detection of the corresponding blood components.
  • a further improvement of the method of the present invention is to divide the different temperatures into a number of grades, preferably 3-5 times.
  • the temperature corresponding to each gear may be the actual body temperature of the part to be tested at the time of the first detection or the temperature of the part to be tested at this time is adjusted to a set temperature (hereinafter referred to as the first test to be tested)
  • the temperature of the portion is an initial temperature or a first temperature, a temperature which is 1 to 50 ° C smaller than the initial temperature or a temperature which is 1 to 50 ° C larger than the initial temperature.
  • the temperature of each grade may be sequentially increased or decreased sequentially from the initial temperature, or may be alternately high or low by the initial temperature or alternately low and high.
  • Another improvement is that, in each detection, in order to make the temperature of the part to be tested in a controllable state, the following method is implemented:
  • the heat generating component 31 can be heated by heat radiation or heat conduction, and the heat generating component 31 is controlled by a peripheral control circuit, and the temperature rise and fall is in an adjustable state, that is, heating or cooling.
  • a further improvement of the present invention is to overcome different detections (the "different detections” refer to cross-site measurements of different parts of the same person to be tested, or cross-sections of the same part to be tested of different people.
  • the detection error caused by measuring the measurement of the body the present invention eliminates this difference by adjusting the distance between the signal receiver 8 and the surface of the human body. That is, when the detection is performed, the measurement error is reduced by adjusting the distance between the signal receiver 8 and the surface of the human body so that the luminous flux of the feedback signal received by the signal receiver 8 is within a predetermined range.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
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  • Emergency Medicine (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un procédé de mesure précise du contenu d'un composant sanguin d'un corps humain à l'aide d'un moyen non invasif et au moyen de la vitesse d'un composant sanguin d'un corps humain absorbant la lumière infrarouge à une fréquence spécifique, et un dispositif associé ayant une structure simple. Le procédé comprend les étapes suivantes consistant à : sélectionner une partie à mesurer (S101); effectuer un réglage de température sur la partie à mesurer (S102); utiliser un signal de détection de lumière infrarouge pour irradier la partie à mesurer (S103); acquérir un signal de retour d'informations (S104); et lorsque la partie à mesurer est à au moins deux températures différentes, acquérir respectivement le signal de retour d'informations à la température correspondante, et obtenir, par calcul, le contenu d'un composant à mesurer dans le sang (S105). Le dispositif de mesure comprend un circuit de commande principal (1), un générateur de signal (2), un dispositif de positionnement (5), un récepteur de signal (8) et un dispositif de réglage de température (3). Le procédé de mesure du contenu d'un composant sanguin d'un corps humain fournit à des chercheurs médicaux une nouvelle idée pour acquérir avec précision le contenu d'un composant sanguin d'un corps humain au moyen d'une détection non invasive, et en particulier pour la recherche sur les caractéristiques multi-spectrales infrarouges d'un biomarqueur d'un cancer. Le dispositif de mesure peut empêcher une détection invasive de provoquer une douleur physique et psychologique à des patients et le risque de contracter des maladies.
PCT/CN2019/081454 2018-04-12 2019-04-04 Procédé de mesure de contenu de composant sanguin d'un corps humain, et dispositif associé WO2019196733A1 (fr)

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CN108553110B (zh) * 2018-04-12 2024-06-18 澳菲科技（深圳）有限公司 测量人体血液成分含量的方法及其装置
CN110090027A (zh) * 2019-06-13 2019-08-06 广东省人民医院(广东省医学科学院) 一种人体蛋白摄入量的无创检测方法及检测装置
CN110367999B (zh) * 2019-07-17 2021-07-09 李宏杰 一种乳腺血氧功能成像辅以热疗早期乳腺癌检测系统

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