WO2019182245A1

WO2019182245A1 - Capsule endoscope device and method for operating same device

Info

Publication number: WO2019182245A1
Application number: PCT/KR2019/001474
Authority: WO
Inventors: 김광섭
Original assignee: 주식회사 인트로메딕
Priority date: 2018-03-19
Filing date: 2019-02-01
Publication date: 2019-09-26
Also published as: KR102097445B1; KR20190109866A

Abstract

One aspect of the present invention provides a capsule endoscope device. The device comprises: a first optical system having a field of vision (FOV) broader than a reference value to observe a target site; a second optical system for magnifying and observing a target site having a size from nanometer (nm) to millimeter (mm); and a transfer part for transmitting an image data acquired from at least one of the first optical system and the second optical system to a receiver.

Description

Capsule Endoscopy Device and Operation Method

The present invention relates to a capsule endoscope, and more particularly, to a capsule endoscope device for efficiently photographing various images and a method of operating the same.

In order to obtain information inside the human body, especially medical information, a method of inserting an endoscope attached to a cable through an examinee's mouth or anus is used. According to this method, since the endoscope can be directly controlled through a cable made of wire or optical fiber, it is easy to secure data inside the human body, but it causes great pain for the subject. In addition, organs such as the small intestine are not only far from the examinee's mouth or anus, but also have a problem in that the body cavity diameter of the organ is small and difficult to be examined by the endoscope method described above.

In view of this, a capsule endoscope has been used. When the examinee swallows the capsule endoscope through the oral cavity, the capsule endoscope acquires the necessary data with a camera in the human body, and transmits the acquired data to a receiver outside the human body for output.

However, capsule endoscopes generally use an optical system that utilizes a wide angle of 100 degrees or more, and although the overall shape of the lesion can be known using the capsule endoscope, it is difficult to identify the precise lesion. In particular, in order to confirm the precise lesions, it was cumbersome, requiring additional procedures such as tissue collection.

An object according to an aspect of the present invention for solving the above problems is to capture an image using a wide-angle optical system and when an abnormal lesion is found, the capsule endoscope device capable of taking an image in units of cells by controlling the position and posture; It provides a method of operation thereof.

Capsule endoscope device according to an aspect of the present invention for achieving the above object has a field of vision (FOV) than the reference value, the first optical system for observing the target area, nanometer (nm) to millimeters (mm) A second optical system for magnifying and observing a target portion having a size, and a transmission unit transmitting image data obtained from at least one of the first optical system and the second optical system to a receiver, wherein the first optical system is larger than the reference value. A first lens having a wide viewing angle, a first image sensor for capturing an image of the target region through the first lens, and a first light source operating in correspondence with the first lens and the first image sensor, The second optical system includes a second lens for observing a target portion in nanometer to millimeter units, and an image of the target portion through the second lens. It may include a second image sensor for photographing and a second light source that operates in correspondence with the second lens and the second image sensor.

The first lens has a viewing angle of 100 degrees or more, and a focal length of the first lens may have a depth of focus of 30 mm or less from a surface of an optical dome surrounding the first lens and the second lens.

The second lens has a focal region of less than 3 mm, and the focal length of the second lens may have a depth of focus of 2 mm or less from the surface of the dome surrounding the first lens and the second lens.

The second light source may be an LED or a laser diode aligned with a focal length and a focal region of the second lens.

The second light source may be a laser diode that is aligned with a focal length and a focal region of the lens to provide light of a fluorescent wavelength band.

The emission period of the second light source may be greater than the emission period of the first light source.

At least one of the first light source and the second light source may include a white LED.

At least one of the first image sensor and the second image sensor may be a complementary metal oxide semiconductor (CMOS) image sensor.

The capsule endoscope device may further include at least one of a color filter between the second image sensor and the second lens and a bandpass filter configured to pass only light of a specific wavelength band.

The capsule endoscope device may further include a magnetic element for controlling position and posture of the capsule endoscope device.

The first lens and the second lens may be disposed on the same plane.

According to another aspect of the present invention, there is provided a method of operating a capsule endoscope device, in which a first optical system observes a target area with a field of vision (FOV) wider than a reference value, and the second optical system is nano Magnifying and observing an object portion of a size ranging from meters (nm) to millimeters (mm) and transmitting image data obtained from at least one of the first optical system and the second optical system to a receiver, wherein the first optical system Observing the target portion with a field of vision (FOV) wider than a reference value may include: generating light through a light emitted from a first light source interlocked with a first lens and a first image sensor having a wider viewing angle than the reference value; And taking an image of the target portion based on the first lens, wherein the second optical system has the target portion of the size of nanometer (nm) to millimeter (mm). Magnifying observation is based on the second lens through the light irradiated from the second light source in conjunction with the second image sensor and the second lens for observing the target area in the nanometer to millimeter unit, the nanometer to millimeter unit Observing the target site of the may include.

According to the capsule endoscope device and its operation method according to an aspect of the present invention, it is possible to grasp the overall shape and position of an organ by using a wide-angle optical system, and to obtain a precise image by using a microscope optical system.

1 is a view showing a capsule endoscope system according to an embodiment of the present invention,

Figure 2 is a view showing the capsule endoscope device as a whole according to an embodiment of the present invention,

Figure 3 is a detailed block diagram showing in detail the configuration of the optical system of the capsule endoscope device according to an embodiment of the present invention,

Figure 4 is a plan view showing the configuration when viewed from the front endoscope capsule capsule according to an embodiment of the present invention,

5 is a view showing the light emission period of the main light source and the negative light source of the capsule endoscope device according to an embodiment of the present invention,

6 is an exemplary view showing a process of performing posture and position control of a capsule endoscope device according to an embodiment of the present invention;

Figure 7 is a block diagram showing in detail the configuration of the capsule endoscope device according to an embodiment of the present invention,

8A and 8B illustrate screens output from an image processing apparatus interoperating with a capsule endoscope apparatus according to an embodiment of the present invention.

As the present invention allows for various changes and numerous embodiments, particular embodiments will be illustrated in the drawings and described in detail in the written description.

However, this is not intended to limit the present invention to specific embodiments, it should be understood to include all modifications, equivalents, and substitutes included in the spirit and scope of the present invention.

Terms such as first and second may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the first component may be referred to as the second component, and similarly, the second component may also be referred to as the first component. The term and / or includes a combination of a plurality of related items or any item of a plurality of related items.

When a component is referred to as being "connected" or "connected" to another component, it may be directly connected to or connected to that other component, but it may be understood that other components may be present in between. Should be. On the other hand, when a component is said to be "directly connected" or "directly connected" to another component, it should be understood that there is no other component in between.

The terminology used herein is for the purpose of describing particular example embodiments only and is not intended to be limiting of the present invention. Singular expressions include plural expressions unless the context clearly indicates otherwise. In this application, the terms "comprise" or "have" are intended to indicate that there is a feature, number, step, operation, component, part, or combination thereof described in the specification, and one or more other features. It is to be understood that the present invention does not exclude the possibility of the presence or the addition of numbers, steps, operations, components, components, or a combination thereof.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art. Terms such as those defined in the commonly used dictionaries should be construed as having meanings consistent with the meanings in the context of the related art, and shall not be construed in ideal or excessively formal meanings unless expressly defined in this application. Do not.

Hereinafter, with reference to the accompanying drawings, it will be described in detail a preferred embodiment of the present invention. In the following description of the present invention, the same reference numerals are used for the same elements in the drawings and redundant descriptions of the same elements will be omitted.

1 is a view showing a capsule endoscope system according to an embodiment of the present invention. As shown in FIG. 1, the capsule endoscope system according to the exemplary embodiment of the present invention may include a capsule endoscope device 120, receiving

electrodes

130a and 130b, and a receiver 150.

Referring to FIG. 1, as the capsule endoscope 120 passes the organs 110, for example, the esophagus, the stomach, the small intestine, or the large intestine, in the human body 100 of the examinee, information about the corresponding organs is obtained. The information that the capsule endoscope 120 may obtain includes bio information obtained from a bio sensor such as predetermined image information, sound information, temperature, pressure, pH, and / or analysis information of a medium in the human body. In this case, the capsule endoscope 120 may have the two or more image sensors and the two or more optical lenses to photograph the organ 110 of the human body 110 to generate a first image and a second image. The first image and the second image may be images captured simultaneously in time.

The obtained information is converted into an electrical signal in the capsule endoscope 120, and detected by the

receiving electrodes

130a and 130b attached to the human body of the examinee. The receiving

electrodes

130a and 130b transmit the received electrical signals to the receiver 150 through the

conductive lines

140a and 140b.

Alternatively, the obtained information may be converted into an electrical signal in the capsule endoscope 120 and transferred directly to the receiver 150 using radio frequency (RF) or human body communication (HBC). . The method using the radio frequency transmits the converted electrical signal to the receiver 150 using a frequency range harmless to the human body. In the method using the human body communication, when an electrode provided on the outer surface of the capsule endoscope 120 contacts the human body according to the interlocking motion of the organ 110 of the human body 100, a current is generated, and the conversion is performed using the current. The electrical signal is transmitted to the receiver 150.

Alternatively, according to another embodiment of the present invention, the capsule endoscope 120 stores image data and other acquired information in a local memory (not shown) in the capsule endoscope 120, and after the photographing is finished, Information stored in the capsule can be delivered to the receiving device or PC.

The receiver 150 receiving the first image and the second image signal from the capsule endoscope 120 may play at least one of the two images through a user interface (GUI).

According to another embodiment of the present invention, the receiver 150 simply receives the first image and the second image, and connects the received image to another image processing device 160 (eg, the receiver 150 by wire or wirelessly). At least one image may be reproduced by transmitting the image data to another PC, a notebook computer, a smart phone, etc.) and performing image processing on the separate image processing apparatus 160.

2 is a view showing the capsule endoscope device as a whole according to an embodiment of the present invention. As shown in FIG. 2, the capsule endoscope device according to the embodiment of the present invention includes a first lens 210, a second lens 212, a first light source 220, a second light source 222, and a color filter. 230 and dome 240.

Referring to FIG. 2, the capsule endoscope may be applied to two or more image sensors, lenses, and light sources. One optical system may include an image sensor, a lens, and a light source, and may be classified into a wide-angle optical system and a microscope optical system according to the performance of the lens.

First, the first lens 210, the first light source 220, and the first image sensor (not shown in the drawing, not shown in the drawing) may form a first optical system. The first optical system may be an ultra wide-angle optical system of 100 degrees or more. However, it does not necessarily need to be 100 degrees or more, and may be a wide angle optical system of 110 degrees and 120 degrees or more. This is useful for observing a wide range of organ mucosa and identifying lesions. In order to observe a wide range, the first light source 220 is preferably wide-angle illumination compared to the second light source 222. The second light source 222 is preferably narrow angle illumination compared to the first light source 220.

In addition, the second lens 212, the second light source 222, and the second image sensor (not shown in the device) may form a second optical system. The second optical system is an optical system having a microscope function capable of capturing the size of the nanometer (nm) to millimeters (mm) unit. It is arranged together with the first optical system. In this case, the second lens 212 may be disposed on the same plane as the first lens 210, and the second light source 222 may also be disposed on the same plane as the first light source 220. The same applies to the positional relationship between the first image sensor and the second image sensor.

The capsule endoscope device according to the embodiment of the present invention including the first optical system and the second optical system as described above takes an image at a wide angle using the first optical system like a general capsule endoscope, and when an abnormal change occurs, the magnetic element By controlling the position and posture of the capsule endoscope using the second optical system it is possible to take images in units of cells. That is, when the capsule endoscope detects an abnormal lesion by simultaneously photographing, the capsule endoscope is moved to a range where the microscope can be seen by controlling the position and position of the capsule endoscope.

The dome surrounds the

lenses

210 and 212 in the form of a dome in a direction in which the capsule endoscope faces the target site. The dome may be called an optical dome. At this time, the first optical system for photographing at a wide angle can photograph at a considerable distance from the optical dome. However, the second optical system is similar to the focal length of the microscope, which may preferably have a focal length of 2 mm or less from the surface of the optical dome. In addition, only a part of the optical dome can capture an image of a microscope. As such, to capture an accurate microscopic image of the lesion, it is desirable to control the position and posture of the capsule endoscope so that the focal length can be adjusted in a specific area of the optical dome.

Figure 3 is a detailed block diagram showing the configuration of the optical system of the capsule endoscope device according to an embodiment of the present invention in detail.

Referring to FIG. 3, the first optical system includes a first lens 310 and a first image sensor 302 (a light source is omitted), and the second optical system includes a second lens 312 and a second image sensor ( 304 and a filter 330.

The first optical system is an optical system having a field of view (FOV) of 100 ° or more, and the light source 302 may include a white light source. The focal length of the first optical system includes 30 mm from the surface of the optical dome. Through such a first optical system, the overall shape or position of the organ may be possible, and the position and posture of the capsule may be controlled using a position control system (see FIG. 6).

The second optical system is an optical system capable of capturing an image of 0.1 to 100 μm, and the focal length photographs a disease at a distance between 0 and 2 mm of the optical dome surface. The FOV (focal region) is less than 3mm and has a very small area of focus in the focal length portion (eg near the dome surface). It is desirable to specialize in using a microscope on a cell basis. At this time, in order to take an image of 0.1 ~ 100㎛, the light source may be attached to the front end of the light source to minimize the angle of view. It may also be desirable to use a laser diode. The LED and / or laser diode used as the second light source is preferably arranged to irradiate light to the focal length and the focal region.

The image sensor 302 of the first optical system may use a complementary metal oxide semiconductor (CMOS) image sensor to capture an image having a viewing angle of 100 ° or more.

As the image sensor 304 of the second optical system, another type of complementary metal oxide semiconductor (CMOS) sensor may be used. It is also possible to use a CMOS image sensor with a color filter 330 (eg, an RGB color filter). However, the filter 330 is not necessarily provided, and an image sensor having a high sensitivity may be used by removing the filter. In addition, a bandpass filter may be used at the front of the filter 330 to receive only a specific wavelength band. Accordingly, it is possible to take a picture of a narrow band. By taking a narrowband image, you can take an image of a dialectic. In addition, by adjusting the wavelength band of the light source to irradiate a light source (Red, Green LED, or Green, Blue or Infra Red) in a special wavelength band, The fluorescence wavelength can be excited. In this case, when the color filter 330 is attached to the front of the image sensor 304 to receive only the self-fluorescence wavelength, a fluorescent image may be obtained. When the light source of the Anm wavelength band is irradiated, the cells may be irradiated with light of the Anm wavelength band to generate an image of the Bnm wavelength band. In this case, it is preferable to use a band pass filter in the second optical system (ie, the microscope optical system) so that only the reflected light is well received. That is, it is preferable to filter out Anm wavelength.

Figure 4 is a plan view showing the configuration when viewed from the front endoscope capsule capsule according to an embodiment of the present invention.

4, four light sources 420-1, 420-2, 420-3, and 420-4 may be disposed around the first lens 410 and the second lens 412. In this case, only one light source (eg, the light source 420-1) may be for the second optical system as a special wavelength band. Here, only one light source is not necessarily associated with the second optical system, and may be two or three.

The light sources 420-2, 420-3, and 420-4 may be white LEDs as main light sources. In this case, the main light source does not necessarily need to be a white LED, but may be a light source of another wavelength band. The light source 420-1 may be illumination for a microscope for generating an image of a special wavelength band. Microscope illumination may utilize green LEDs or laser diodes of a particular wavelength band (such as Red, Green, Blue or Infra Red). In this case, since the light source 420-1 is for capturing the microscope image of the lens 412 of the second optical system, the light source 420-1 is considered to reflect the focus area of the second lens 412, so that the actual image is taken from the dome surface part. I should be able to give That is, in consideration of the positional relationship associated with the focus area, it is preferable that the light source 420-1 properly focus the light of the special wavelength band toward the focus area. In addition, the second light source may be two or more, and may include light sources of different wavelength bands. In addition, a plurality of second image sensors may be provided, and the plurality of second image sensors and the plurality of second light sources may be matched, respectively, to periodically generate images of different wavelength bands.

5 is a view showing the light emission period of the main light source and the negative light source of the capsule endoscope device according to an embodiment of the present invention.

Since the focal region according to the wide viewing angle of the first lens includes the focal region of the second lens, the light source for the first image obtained through the first lens may be required to irradiate light also to the region associated with the second lens. have. That is, both the first light source and the second light source may be irradiated to the second lens (see FIG. 3). Accordingly, a plurality of first light sources may be arranged and may be arranged around the second lens (see FIG. 4).

However, in such a situation, in order to acquire a microscope image according to the second optical system, only the second light source for the second image in a state in which the first light source for the first image, that is, the general white LED light source is turned off. Light should be irradiated to the focal region of this second lens. To this end, as shown in FIG. 5, a period of each of the first light source and the second light source may be set to allow the first light source to operate in the 1, 2, and 3 frames, and the second light source to operate in the 4 frames. have. That is, it is preferable to independently assign a time when the first light source is activated for the first image acquisition and a time when the second light source is activated for the second image acquisition. The period setting may be a ratio of 1: 1, and in general, when the abnormality is found after the first image is continuously utilized, the second image is utilized, so that the period of the first light source is 3: 1, or 4 You can also make it more weight with a: 1. The setting of these periods can be adjusted through user settings. Alternatively, the capsule endoscope may be configured to receive an external signal so as to switch from the first light source to the second light source or from the second light source to the first light source in response to a signal from the outside.

6 is an exemplary view showing a process of performing posture and position control of the capsule endoscope device according to an embodiment of the present invention.

If abnormal lesions are found in the general image, the position and posture of the capsule endoscope may be required to examine the corresponding portion through the microscope optical system in detail. At this time, it is preferable to utilize magnetic force.

As shown in FIG. 6, the capsule endoscope device 600 is inserted into the human body and positioned inside the organ inner wall 610. The magnetic controller 650 and the monitoring terminal (not shown) may be located outside the human body, and according to an aspect, the magnetic controller 650 may be located in close contact with the skin 630. By operating the capsule endoscope device 600 under the control of the magnetic controller 650, an image of a peripheral organ 620 other than the organ where the capsule endoscope device 600 is located may be acquired.

The magnetic controller 650 may release magnetic force for controlling the movement of the capsule endoscope device 600. The magnetic force may be generated by providing the permanent magnet, and the magnetic force transmitted to the capsule endoscope device 600 may be adjusted by controlling the movement of the magnetic transmitter such as the permanent magnet by including the driving motor. In addition, the magnetic controller 600 may adjust the strength of the magnetic force transmitted to the capsule endoscope device 600, and may adjust the speed of the movement (for example, rotation or movement) for acquiring the microscope image.

For example, when the magnetic controller 650 performs a linear repeating motion, the capsule endoscope device 600 may also perform a linear repeating motion in response to the magnetic force emitted by the magnetic controller 650, and the capsule endoscope device 600. ) May obtain a general image and a microscope image based on light emitted through the light source and light reflected from the surrounding organs 620 and returned.

Figure 7 is a block diagram showing in detail the configuration of the capsule endoscope device according to an embodiment of the present invention. As shown in FIG. 7, the capsule endoscope device 700 according to the exemplary embodiment of the present invention may include a first lens 710, a second lens 712, a first light source 720, and a second light source 722. , The magnetic element 730, the first image sensor 740, the second image sensor 742, the controller 750, the power supply unit 760, the transmitter 770, and the inertial sensor 780.

Referring to FIG. 7, the first lens 710 is a lens of the first optical system. As described above, the first lens 710 has a viewing angle of 100 ° or more and a focal length is 30 mm or less from the dome surface.

The first light source 720 operates in correspondence with the first lens 710 and the first image sensor 740, and provides light for capturing a general capsule endoscope image. Typically white LEDs can be used. Plural can be utilized.

The first image sensor 740 is a component for capturing an image of a target portion seen through the first lens 710. The first image sensor 740 includes a CMOS image sensor.

The second lens 712 is a lens of the second optical system. As described above, the second lens 712 has a focal region of 30 mm or less, and a focal length (called depth of focus) is 2 mm or less from the dome surface.

The second light source 722 operates in correspondence with the second lens 712 and the second image sensor 742, and provides light for capturing a microscope image. At least one of a white LED, a special wavelength LED, an LED used with a lens, and a laser diode may be used.

The second image sensor 742 is a component for capturing an image of a target portion seen through the second lens 712. The second image sensor 742 includes at least one of a CMOS image sensor, an image sensor including a color filter, and an image sensor including a band pass filter.

The controller 750 controls the first light source 720 and the second light source 722 according to the set operation period of the first light source 720 and the second light source 722. In addition, the first image and the second image are obtained from the first image sensor 740 and the second image sensor 742 and transmitted to the transmitter 770.

The controller 750 may control at least one of the first light source 720 and the second light source 722, the first image sensor 740, and the second image sensor 742 based on a control signal received from the outside. have.

The controller 750 may be manufactured using an ASIC chip, and may be configured to transfer data generated by the first image sensor 740 and the second image sensor 742 into frames and transmit the data to the transmitter 770.

The controller 750 may also control the frame per second (FPS) of at least one of the first image sensor 740 and the second image sensor 742, and the position of the current capsule endoscope obtained from the inertial sensor 780. It is also possible to adaptively change the FPS according to the posture.

The magnetic element 730 may control to perform a movement for acquiring a microscope image in response to a magnetic force from the magnetic controller 750 external to the capsule endoscope device 700. Here, the magnetic element 730 may be composed of, for example, one or more permanent magnets. The power supply unit 760 may be disposed between the permanent magnets, and the N pole and the S pole of the permanent magnet may be disposed as widely as possible.

The power supply unit 760 may supply power to the capsule endoscope device 700 and may include one or more batteries. In addition, the one or more batteries may include a rechargeable battery.

The transmitter 770 transmits the first and second images acquired by the

image sensors

740 and 742 to the receiver 715 outside the capsule endoscope device. Also, a control signal from an external device can be received. The outside of the capsule endoscope device 700 may be, for example, a monitoring device (not shown), and may be any one of a separate external control device and an external display device according to the configuration of the capsule endoscope system. That is, the transmitter 770 supports a communication function with an external unit of the capsule endoscope device 700, and the communication method is a radio frequency (RF) method or a human body communication (HBC) as described above. At least one of the schemes may be used. The transmitter 770 may be configured of one or more ASICs for implementing a communication function, and may include one or more antennas. Depending on the configuration of the capsule endoscope system, it may support one-way communication or two-way communication.

The inertial sensor 780 can be used to measure the orientation or posture and position of the capsule endoscope device 700. That is, the inertial sensor 780 may obtain information about the posture and the position of the capsule endoscope device 700, and the information about the posture and the position of the capsule endoscope device 700 may be adaptively controlled in the image capturing. Can be used for

Referring to FIG. 8A, the image processing apparatus may receive a normal image (first image) and a microscope image (second image) from a capsule endoscope device. In this case, the image processing apparatus may display the general image and the microscope image in real time together on a single screen.

Referring to FIG. 8B, the image processing apparatus basically displays a general image on the screen, and then a abnormal lesion is detected and a series of processes for acquiring a microscope image (for example, the position and posture of the capsule endoscope take a microscope image). Control, microscope imaging, and receiving the captured microscope image), the image may be switched to display the microscope image. When an abnormal lesion is detected using an algorithm for tracking abnormal lesions, in response to the detected abnormal lesion, a control signal associated with microscopic image generation is transmitted to the capsule endoscope device, and the capsule endoscope device receiving the abnormal lesion is received. When the microscope image is generated through posture and position control, the image processing apparatus may adaptively process the received image. That is, the user may automatically process the display of the microscope image by applying the abnormal lesion tracking algorithm in advance.

Although described above with reference to the drawings and embodiments, it does not mean that the scope of protection of the present invention is limited by the above drawings or embodiments, and those skilled in the art to the spirit of the present invention described in the claims It will be understood that various modifications and variations can be made in the present invention without departing from the scope of the invention.

Claims

In a capsule endoscope device,

A first optical system for observing a target site with a field of vision (FOV) wider than a reference value;

A second optical system for enlarging and observing an object portion of a size ranging from nanometer (nm) to millimeter (mm); And

Including a transmitter for transmitting the image data obtained from at least one of the first optical system and the second optical system to the receiver,

The first optical system operates in response to a first lens having a wider viewing angle than the reference value, a first image sensor for capturing an image of the target region through the first lens, and the first lens and the first image sensor. Including a first light source,

The second optical system includes a second lens for observing a target portion in nanometer to millimeter units, a second image sensor for capturing an image of the target portion through the second lens, and the second lens and the second image. A capsule endoscope device comprising a second light source operating in correspondence with a sensor.
The method of claim 1,

The first lens has a viewing angle of 100 degrees or more,

The focal length of the first lens has a depth of focus of less than 30mm from the surface of the optical dome surrounding the first lens and the second lens.
The method of claim 1,

The second lens has a focal region of less than 3 mm,

The focal length of the second lens has a depth of focus of less than 2mm from the surface of the dome surrounding the first lens and the second lens.
The method of claim 3, wherein

And the second light source is an LED or a laser diode aligned with the focal length and the focal region of the second lens.
The method of claim 4, wherein

And the second light source is a laser diode that is aligned with a focal length and a focal region of the lens to provide light of a fluorescent wavelength band.
The method of claim 1,

The light emitting period of the second light source is larger than the light emitting period of the first light source capsule endoscope device.
The method of claim 1,

At least one of the first light source and the second light source includes a capsule endoscope device.
The method of claim 1,

At least one of the first and second image sensors is a Complementary Metal Oxide Semiconductor (CMOS) image sensor.
The method of claim 1,

And at least one of a color filter and a bandpass filter for passing only light of a specific wavelength band between the second image sensor and the second lens.
The method of claim 1,

A capsule endoscope device further comprising a magnetic element for position and posture control of the capsule endoscope device.
The method of claim 1,

And the first lens and the second lens are disposed on the same plane.
In the operating method of the capsule endoscope device,

Observing the target site by the first optical system having a field of vision (FOV) wider than a reference value;

The second optical system magnifies and observes a target portion of a size ranging from nanometers (nm) to millimeters (mm); And

Transmitting image data obtained from at least one of the first optical system and the second optical system to a receiver,

Observing the target area with the field of vision (FOV) wider than the reference value by the first optical system may include light emitted from a first lens having a wider viewing angle than the reference value and a first light source interlocked with the first image sensor. And photographing an image of the target portion based on the first lens.

The step of enlarging and observing the target area of the nanometer (nm) to the millimeter (mm) size by the second optical system may include a second light source that is interlocked with the second image sensor and the second lens for observing the target area in nanometer to millimeter units. The method of operating the capsule endoscope device comprising the step of observing the target site in the unit of nanometers to millimeters based on the second lens through the light irradiated from the.