WO2019178448A1 - Compositions de cire de tabac vaporisables et récipient associé - Google Patents

Compositions de cire de tabac vaporisables et récipient associé Download PDF

Info

Publication number
WO2019178448A1
WO2019178448A1 PCT/US2019/022417 US2019022417W WO2019178448A1 WO 2019178448 A1 WO2019178448 A1 WO 2019178448A1 US 2019022417 W US2019022417 W US 2019022417W WO 2019178448 A1 WO2019178448 A1 WO 2019178448A1
Authority
WO
WIPO (PCT)
Prior art keywords
tobacco
wax composition
tobacco wax
heating element
cartridge
Prior art date
Application number
PCT/US2019/022417
Other languages
English (en)
Inventor
Joseph M. Fuisz
Seamus Henry
Original Assignee
Bond Street Manufacturing Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/923,587 external-priority patent/US20180199618A1/en
Priority claimed from US16/159,015 external-priority patent/US10918127B2/en
Application filed by Bond Street Manufacturing Llc filed Critical Bond Street Manufacturing Llc
Priority to EP19767298.3A priority Critical patent/EP3764823A4/fr
Priority to CN201980032310.2A priority patent/CN112566519A/zh
Priority to US16/981,210 priority patent/US20210007389A1/en
Publication of WO2019178448A1 publication Critical patent/WO2019178448A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/10—Chemical features of tobacco products or tobacco substitutes
    • A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
    • A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
    • A24B15/241—Extraction of specific substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
    • A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
    • A24B15/18—Treatment of tobacco products or tobacco substitutes
    • A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/42—Cartridges or containers for inhalable precursors
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
    • A24F40/46—Shape or structure of electric heating means
    • A—HUMAN NECESSITIES
    • A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
    • A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
    • A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
    • A24F40/20—Devices using solid inhalable precursors

Definitions

  • Tobacco wax or resin is dark brown in color, bums with the production of acrid fumes, and has a strong odor resembling that of an“old” pipe.”
  • the tobacco wax may be used as an insecticide or may be“returned to the residual tobacco leaves and also to untreated tobacco leaves to impart thereto desirable flavors.”
  • Gamer teaches that the extracted tobacco is still suitable use in smoking and other tobacco products (US 2,128,043).
  • Keritsis et al (assigned to Philip Morris) (US 4,936,920) (1990) mentions tobacco wax in a list of saccharides and polysaccharides that may be used as a bonding agent when making manufactured tobacco (more typically referred to as reconstituted tobacco sheet) .
  • isoprene yield can be taken as representative of the amount of homogenized tobacco material that is“over heated.””
  • tobacco wax has been purposefully used in this composition or otherwise present than through the natural presence of wax in the tobacco used to manufacture the “homogenized tobacco material.”
  • Applicant understands the substrate described in this art to be a reconstituted tobacco sheet intended for use in heat not burn applications.
  • Brown et al. (assigned to Lorillard) (US 9,038,644) (2015) teaches tobacco wax for use as a phase transition material to impart reduced ignition propensity to a cigarette.
  • the wax is applied to the cigarette paper using high precision wax jet printing.
  • compositions include USP (99.9% pure) nicotine oil as an ingredient, though zero-liquids without any nicotine are also used.
  • Heat not burn tobacco systems are known in the tobacco industry. Heat not bum systems like Pax Lab’s Pax® and Philip Morris’ IQOS® (as well as earlier versions of IQOS® sold as Heatbar® and Accord®) heat tobacco compositions substantially without burning the tobacco, thereby aerosolizing volatile constituents of the tobacco composition. After use, the non-vaporized components of the tobacco composition remain minus those components what were successfully vaporized (or inadvertently burned) .
  • Pax is a loose-leaf style vaporizer for use with“loose-leaf plant material” supplied by the user herself (https:/ /www.paxyapor.com/ support/pax-2-faq/#can-i-use-liquids-in-pax-2).
  • Philip Morris’ IQOS is a more sophisticated product wherein the user uses a manufacturer-supplied “cigarette” in the heating device.
  • the cigarette itself is comprised of reconstituted tobacco sheet made with high amounts of humectant (glycerin) that, together with other volatiles, create a vapor like experience when used.
  • composition of the reconstituted sheet used in IQOS is akin to that described in W02016050472A1, assigned to Philip Morris.
  • One of the present inventors has extensive experience working with film and sheet systems, principally for pharmaceutical applications and is a named inventor on Fuisz et al. 9,108,340; 8,906,277; 8,685,437; 8,663,687; 8,652,378; 8,617,589; 8,613,285; 8,603,514; 8,241,661; 8,017,150; 7,972,618; 7,897,080; 7,824,588; 7,666,337; and 7,425,292.
  • the present invention relates to a tobacco wax composition suitable for vaporization, comprising tobacco wax and at least one vapor agent.
  • the tobacco wax composition can have a nicotine content of greater than 2%.
  • the tobacco wax composition is preferably flowable.
  • the tobacco wax composition may further comprise at least one selected from the group of: an emulsifying agent, or a surfactant.
  • the tobacco wax composition is preferably substantially free of separation when stored at room temperature conditions for six months.
  • the tobacco wax composition preferably comprises 30% to 65% of a vapor agent.
  • the tobacco wax composition can be contained in a pod.
  • the tobacco wax composition may be coated on a heated rod.
  • the pod may have a top porous layer.
  • the present invention also relates to a combination of the tobacco wax composition and a cartridge, wherein the tobacco wax composition is contained in the cartridge.
  • the areas of the cartridge in contact with the tobacco wax composition may comprise a material with a surface energy of less than 20 Dynes / cm.
  • the material with a surface energy of less than 20 Dynes/cm may comprises PTFE or FEP.
  • the present invention also relates to a system for vaporization of a tobacco wax composition, comprising a device and a pod containing a tobacco wax composition, said tobacco wax
  • composition comprising tobacco wax and at least one vapor agent.
  • the system may have vapor emissions with TSNA levels below quantifiable limits on a per puff basis, when measured using: 55mL puff/ 30 sec interval/ 3 sec duration, and the quantifiable limit is 0.20 ng/puff
  • the system may have formaldehyde emissions of below quantifiable limits on a per puff basis, when measured using: 55mL puff/ 30 sec interval/ 3 sec duration, and the quantifiable limit is 0.20 pg/puff
  • the system may have vapor emissions of formaldehyde of less than 50% of the IQOS Heet comparator, testing using the Canadian Intense smoking regime.
  • the system may have on off functionality
  • the system may have an operating temperature within the range of 160° C to 240° C.
  • the tobacco wax composition When sufficiently heated, the tobacco wax composition may have a utilization rate of greater than 80%. Preferably, the system reaches operating temperature within ten seconds or less, more preferably within five seconds or less, even more preferably within three seconds or less.
  • the pod may comprise airholes that align with device airholes.
  • the pressure drop of the system is 75 (mm H 2 0) to 130 mm (H 2 0).
  • the device may comprise a sleeve.
  • the system is preferably such that, when sufficiently heated, the tobacco wax composition vaporizers substantially without residue.
  • the present invention also relates to a method for manufacturing a heat not burn tobacco product, comprising extracting the wax partition from tobacco leaf, and mixing that extraction with a vapor agent.
  • the present invention also relates to a method for manufacturing a heat not burn tobacco product, comprising extracting the wax partition from tobacco leaf, extracting an oil partition form tobacco leaf, and mixing these extractions with a vapor agent.
  • the extraction method employed may be supercritical C0 2 extraction.
  • the wax partition and the oil partition may be extracted separately from tobacco leaf and subsequently mixed together.
  • compositions other than tobacco wax including inter alia any botanical wax or botanical oil.
  • Figure 1 is a perspective view showing a heating chamber containing a tobacco wax composition.
  • Figure 2 is an exploded perspective of the heating chamber sub assembly, including a ceramic heating chamber.
  • Figure 3 is a cross-sectional view of the heating chamber containing a tobacco wax composition.
  • Figure 4 is a cross section of the wall of the heating chamber casing.
  • Figure 5 is a cross section of the receiver for the heating chamber, including the battery connection section.
  • Figure 6 is a cross section of the electrode.
  • Figure 7 is a cross section of the electrode insulator.
  • Figure 8 is a perspective view of a ceramic pod showing a printed or coated heating element and positive and negative electrical contacts.
  • Figure 9 is an exploded perspective view of a pod, a porous layer, and a barrier layer.
  • Figure 10 is a perspective view of an alternative embodiment using a cartridge.
  • Figure 11 is a cross section of a cartridge, showing a secondary heater that is adhered to the internal surface of the cartridge.
  • Figure 12 is a cross section of a cartridge, showing a secondary heater that extends into the cartridge’s reservoir.
  • Figure 13 is a cross section of a cartridge with a thermally conductive material on the walls of the cartridge that conducts heat from the primary, vaporizing heating element.
  • Figure 15 is a perspective top view of the alternative embodiment in which the secondary heater is provided on the vaporization device’s receiving chamber.
  • Figure 16 is a perspective view of the alternative embodiment in which the secondary heater is provided on the vaporization device’s receiving chamber.
  • the present invention teaches a composition that comprises tobacco wax and other ingredients suitable for vaporization and use by a mammal.
  • Applicants have found that the vaporization of a tobacco wax based composition provides excellent organoleptics and nicotine delivery.
  • tobacco wax compositions of the present invention vaporize substantially in their entirety (i.e. substantially without residue).
  • vaporize substantially it is meant that the tobacco wax composition will vaporize substantially without residue when exposed to adequate vaporization temperatures (i.e.
  • tobacco wax compositions of the present invention may be more or less flowable.
  • the role of plant wax for plants is understood. Plants secrete waxes into and on the surface of their cuticles as a way to control evaporation, wettability and hydration.
  • the epicuticular waxes of plants are mixtures of substituted long-chain aliphatic hydrocarbons, containing alkanes, alkyl esters, fatty acids, primary and secondary alcohols, diols, ketones, aldehydes. From the commercial perspective, the most important plant wax is carnauba wax, a hard wax obtained from the Brazilian palm
  • extraction methods include, without limitation, subcritical C02 extraction; supercritical C02 extraction; supercritical extraction with additional (non-C02) solvents; maceration; digestion (a heated form of maceration); decoction; percolation; hot continuous extraction (Soxlet); Aqueous Alcoholic Extraction by Fermentation; Counter-current Extraction; Ultrasound Extraction (Sonication); and the Phytonics Process.
  • Solvents used may be polar or non-polar. Various combinations and/ or sequential series of these methods can be used
  • the non-limitative preferred embodiment is supercritical C02 extraction.
  • the use of supercritical C02 extraction to de-nicotinize tobacco is disclosed in Howell et al US 8,887,737 (2014), which is hereby incorporated by reference as if fully set forth herein.
  • Extraction can be used to generate several partitions from tobacco, broadly speaking, including oils and waxes. Both of these partitions contain nicotine.
  • the partitions may be extracted separately, or together, depending on extraction set-up.
  • a single separator is used, employing phase transition to extract into the single separator.
  • one separator may be used for wax partition, and other for oil partition.
  • One separator may use sub-critical parameters (with a pressure of 30-70 bar, preferably 35-60 bar), and another separator may use super-critical parameters (with a pressure of 90-170 bar, preferably 100-150 bar).
  • the wax partition yield should exceed 1% of the starting tobacco weight (or mass), preferably 2% or greater, most preferably 4% or greater.
  • the oil partition yield should exceed 1% of the of the starting tobacco weight (or mass), preferably 1.5% or greater, more preferably 2.5% or greater.
  • the wax and oil partitions should comprise 3-8% of the starting weight (or mass), or greater than 4% of the starting weight (or mass), or preferably greater than 5% of the starting weight (or mass). Extraction processes may be configured to extract both the wax and oil together in a single partition, with the same sum weight (or mass) described in the immediately preceding sentence.
  • All forms of tobacco may be used including tobacco leaf, stem, and waste tobacco dust. Blends of tobacco may be employed. Cigar tobaccos may be employed. Tobacco varieties with high nicotine content are preferred, including to minimize processing requirements. Because the extraction process may bring flavors and aromas from the leaf into the wax and oil, the tobacco inputs may be selected in whole or in part for taste. It may be desirable to pre-treat the tobacco prior to extraction with a basic agent (e.g. sodium carbonate) to encourage nicotine extraction from the tobacco.
  • a basic agent e.g. sodium carbonate
  • the tobacco blending process will be carried out prior to extraction, or after extraction.
  • a blend may be made of one or more tobaccos (e.g. flue cured, burley and Turkish) and extraction made therefrom.
  • the three tobaccos of the prior example may be separately extracted, and blended to taste and other characteristics using the extracted wax partitions (and oil partitions, optionally) of each extracted tobacco type.
  • extraction techniques to remove the wax partition may also function to extract undesired TSNA’s from tobacco.
  • supercritical C02 extraction may solubilize TSNA’s from the tobacco, concentrating them in the resulting wax and oil partitions. Since it is desirable to minimize TSNA’s in the final product, it is desirable to use tobacco inputs with very low TSNA’s. This will result in a product with low TSNA’s without the need for optional pre or post processing steps to remove TSNA’s from the wax partition.
  • the tobacco input have a TSNA level below 3 ppm, more preferable below 2 ppm, still more preferably below 1 ppm, and even more preferably below 0.3 ppm, and most preferably below 0.1 ppm).
  • Tobacco input may be selected with minimal pesticide levels.
  • Pre and or post processing steps may be employed to minimize (or increase) undesired (or desired) constituents.
  • pre-processing we mean steps taken to modify the tobacco prior to the extraction process.
  • Such pre-processing steps may involve grinding tobacco to desired size, controlling moisture levels, stripping tobacco stems, treating tobacco with a pH agent, etc.
  • post-processing we mean steps taken to modify the wax and/ or oil partitions extracted from the tobacco input.
  • pesticide levels in the wax and/ or oil partitions may be reduced using a variety of methods.
  • One such method is chromatography. Chromatography separation, relying on compound polarity, is an effective method to reduce and/ or eliminate undesired pesticide levels or other undesired compounds. Other known separation methods may be so employed in post processing.
  • a Buchi flash chromatography system or other suitable equipment, may be employed.
  • the tobacco wax composition will have residue levels at or below the guidance residue levels set forth in Coresta Guide N 1 (“The Concept and Implementation of CPA Guidance Residue Levels) (July 2016 with additional CP added June 2018), which is incorporated herein in its entirety, or below the levels described in the Examples below.
  • Extraction parameters may impact the nature of the wax partition, including various parameters including flavor, nicotine levels, TSNA levels, and the rheology of the wax partition itself. In certain embodiments, it may be desirable to extract a non-flowable wax partition, or a substantially non-flowable wax partition.
  • the wax partition may be viscous and flowable or somewhat flowable in certain embodiments.
  • the oil partition will be flowable in most embodiments.
  • the oil partition may be mixed into the resulting wax partition to increase the yield of wax and nicotine.
  • High shear mixers and other mixing methods may be used for this purpose.
  • the mass of the oil partition added to the wax partition will be less than or about 75% of the mass of the wax partition, preferably less than or about 30% and most preferably less than 15% of the mass of the wax partition (measured by mass).
  • the oil partition can serve to increase nicotine, enhance flavor, increase vapor production and generally extend the yield from tobacco.
  • TSNA levels may concentrate in the oil partition, and so it is desirable to specifically monitor the TSNA level of the oil partition when considering the desired combination of the two partitions. Similarly, other analytes may be considered.
  • Additional excipients may be employed to develop a final composition for vaporization.
  • Vapor agents may be added to the wax.
  • a vapor agent as a material that increases the vapor from the wax composition when heated.
  • Vapor agents may include, without limitation, vegetable glycerin, non-vegetable forms of glycerin, propylene glycol, polyethylene glycol, polysorbates including polysorbate 20 (polyoxyethylene sorbitan monolaurate), polysorbate 40 (polyoxyethylene (20) sorbitan monopalmitate), polysorbate 60 (polyoxyethylene sorbitan monostearate) and polysorbate 80 (polyoxyethylene sorbitan monooleate.), and other agents suitable for increasing the“vapor” from a heated composition, but“vapor agents” do not include nicotine, typical flavoring agents or tobacco.
  • Vapor agents may be added to about 70% of the composition (by mass), preferably 30-65% of the composition (by mass), most preferably 45- 55% (by mass) of the composition. Lower levels, for example 10% and above, of vapor agents may also be employed, resulting in a stronger, more concentrated final composition. Above 60%, the final composition may become too flowable for certain vaporization devices.
  • all or substantially all of the vapor agent employed is vegetable glycerin. This is because vegetable glycerin has a relatively high viscosity, and flowability of the final composition is undesired in certain embodiments. For example, a flowable composition may“spill” out of the heating chamber when a vaporizer is left on its side.
  • film formers and gelling agents may optionally be employed to increase viscosity as needed.
  • the wax compositions of the present invention are generally not wickable— or capable of wicking or capillary action at low temperatures. Thus, the device used to vaporize the wax compositions of the present invention is not a conventional e-cigarette in most embodiments.
  • High shear mixing is important to ensure uniform distribution of the vapor agent (or other added excipient) in the composition.
  • the tobacco wax may tend towards hydrophobicity, which may present mixing challenges.
  • the use of an emulsifying agent may be desired to assist in emulsifying the mixed composition.
  • emulsifying agents are examples of emulsifying agents that may be employed: agar, albumin, alginates, casein, ceatyl alcohol, cholic acid, desoxycholic acid, diacetyl tartaric acid esters, egg yolk, glycerol, gums, carrageenan, lecithin, mono- and diglycerides, monosodium phosphate, monostearate, ox bile extract, propylene glycol, soaps, or taurocholic acid (or its sodium salt).
  • non-glycerol emulsifying agents are preferred.
  • Emulsifying agents may comprise 0.01% to 5% of the tobacco wax composition, or more in certain embodiments.
  • surfactants may be employed in certain embodiments to promote mixing.
  • Surfactants lower tension between a surface and a liquid or between two or more immiscible
  • Anionic surfactants contain anionic functional groups at their head, such as
  • Prominent alkyl sulfates include ammonium lauryl sulfate, sodium lauryl sulfate (sodium dodecyl sulfate, SLS, or SDS), and the related alkyl-ether sulfates sodium laureth sulfate (sodium lauryl ether sulfate or SLES), and sodium myreth sulfate.
  • Others include: Docusate (dioctyl sodium sulfosuccinate) Perfluorooctanesulfonate (PFOS)
  • Carboxylates are the most common surfactants and comprise the alkyl carboxylates (soaps), such as sodium stearate. More specialized species include sodium lauroyl sarcosinate and carboxylate-based fluorosurfactants such as perfluorononanoate, perfluorooctanoate (PFOA or PFO). Certain surfactants contain cationic head groups. Zwitterionic (amphoteric) surfactants have both cationic and anionic centers attached to the same molecule.
  • the cationic part is based on primary, secondary, or tertiary amines or quaternary ammonium cations.
  • the anionic part can be more variable and include sulfonates, as in the sultaines CHAPS (3-[(3-Cholamidopropyl)dimethylammonio]-l- propanesulfonate) and cocamidopropyl hydroxysultaine.
  • Betaines such as cocamidopropyl betaine have a carboxylate with the ammonium.
  • the most common biological zwitterionic surfactants have a phosphate anion with an amine or ammonium, such and
  • Surfactants may comprise 0.01% to 5% of the tobacco wax composition.
  • a wetting agent may be employed.
  • a wetting agent is a surfactant that, when dissolved in water, lowers the advancing contact angle, aids in displacing an air phase at the surface, and replaces it with a liquid phase.
  • Examples of application of wetting to pharmacy and medicine include the displacement of air from the surface of sulfur, charcoal, and other powders for the purpose of dispersing these drugs in liquid vehicles; the displacement of air from the matrix of cotton pads and bandages so that medicinal solutions can be absorbed for application to various body areas; the displacement of dirt and debris by the use of detergents in the washing of wounds; and the application of medicinal lotions and sprays to surface of skin and mucous membranes.
  • Wetting agents may comprise 0.01% to 5% of the tobacco wax composition.
  • Tween is a nonionic surfactant and emulsifier that is particularly useful in connection with certain embodiments of the present invention.
  • Various Tweens can be used, including inter alia Tween 20 and Tween 80.
  • Tobacco leaf may be added to the wax composition, in any known form, including without limitation shreds, dust, particles and the like.
  • Said tobacco leaf may be leaf from which the tobacco wax was extracted in certain embodiments.
  • Tobacco leaf, including reconstituted tobacco leaf, may be present from .01 to 30% mass of the composition in certain embodiments. Adding tobacco leaf to the composition can provide a look and feel of the product akin to Shisha tobacco. Certain embodiments may be treated, as a regulatory matter, as Shisha.
  • the nicotine content of the final tobacco wax composition is preferably less than 12%, more preferably less than 7.5% and most preferable less than 4%. Certain embodiments will have a nicotine range of 1.5-5.5%, preferable 2.5-4% (by mass). Low nicotine compositions with nicotine less than 1.5%, or even less than 0.5% may also be made for users seeking lower nicotine delivery. Nicotine, natural or synthetic, may be added where the tobacco extraction yields a less than desired
  • the product can be made from low-nicotine containing tobacco to achieve a low nicotine level, or otherwise subject to known processes to de-nicotinize the extractions or starting input tobacco. In certain embodiments seeking a low nicotine level, no oil partition is used.
  • Flavors may be added to the wax. Flavors may be synthetic or natural. For purposes hereunder, menthol, wintergreen, peppermint and similar oils used in menthol tobacco products are
  • Flavors may comprise 0.25% to 20%, preferably 2.5% to 12.5%, more preferably 2.% to 4.5% of the final composition. Special concern should be paid to miscibility and successful homogenization of the flavor with the wax composition.
  • Ball bearings, or analogous mechanical means may be used for mixing in a pod including a cartridge.
  • Penetration agent(s) may be added to the tobacco wax.
  • penetration agents we mean an agent that promotes transfer of the active—i.e., a substance that enhances absorption through the mucosa, mucosal coating and epithelium otherwise known (see U.S. Patent Application Publication No. 2006/0257463 Al, the content ofwhich is incorporated herein by reference).
  • the penetration agent may comprise but is not limited to polyethylene glycol (PEG), diethylene glycol monoethyl ether (Transcutol), 23-lauryl ether, aprotinin, azone, benzalkomin chloride, cetylperidium chloride, cetylmethylammonium bromide, dextran sulfate, lauric acid, lauric acid/ propylene glycol, lysophosphatilcholine, menthol, methoxysalicylate, oleic acid, phosphaidylcholine, polyoxyethylene, polysorbate 80, sodium EDTA, sodium glycholated, sodium glycodeoxycholate, sodium lauryl sulfate, sodium salicylate, sodium taurocholate, sodium taurodeoxycholate, sulfoxides, and various alkyl glycosides or, as described in U.S.
  • PEG polyethylene glycol
  • Transcutol diethylene glycol monoethyl ether
  • bile salts such as sodium deoxycholate, sodium glycodeoxycholate, sodium taurocholate and sodium glycocholate
  • surfactants such as sodium lauryl sulfate, polysorbate 80, laureth-9, benzalkonium chloride, cetylpyridinium chloride and polyoxyethylene monoalkyl ethers such as the BRIJ® and MYRJ® series
  • benzoic acids such as sodium salicylate and methoxy salicylate
  • fatty acids such as lauric acid, oleic acid, undecanoic acid and methyl oleate
  • fatty alcohols such as octanol and nonanol, laurocapram
  • the polyols propylene glycol and glycerin, cyclodextrins
  • the sulfoxides such as dimethyl sulfoxide and dodecyl methyl sulfoxide
  • the terpenes such as ment
  • the penetration agent is selected to be capable of transfer through vaporization.
  • Buffer agents may be added to the tobacco wax, including without limitation to create static or a dynamic buffer systems.
  • the buffer agent is used to raise the pH of the mouth in order to increase nicotine absorption in the buccal cavity in a manner which is based on pka and the Henderson Hasselbach equation.
  • the pH of the mouth is increased to 7 to 10, preferably 7.8 to 10, most preferably from 8.5 to 9.5.
  • the buffer agent increases the pH of the oral cavity for a period of ten minutes or more after administration
  • Buffering agents may be used to control pH, including without limitation, sodium bicarbonate, potassium bicarbonate, sodium carbonate, potassium carbonate, calcium carbonate, dipotassium phosphate, potassium citrate, sodium phosphate and any other such buffer system.
  • the buffer system may be designed to dynamically control the pH of the product taking into consideration the effect of saliva during use, i.e., a dynamic buffer system.
  • buffer systems to obtain the preferred pH include dibasic sodium phosphate and monobasic sodium phosphate. Both are FDA accepted buffer materials used and listed in the inactive ingredients list.
  • the ratio of monobasic/dibasic can be 4.6/8.6; for a pH of 7.5 the ratio of monobasic/dibasic can be 1.9/11.9; and for a pH of 8.0 the ratio of monobasic/ dibasic can be 0.6/ 13.4.
  • Nicotine salts may be employed in certain embodiments. This involves complexing nicotine with an acid, to form a salt. Suitable acids may include without limitation: pyruvic acid, salicylic acid, sorbic acid, lauric acid, levulinic acid, or benzoic acid. US 9,215,895 (Nicotine salt formulations for aerosol devices and methods thereof) and US 20080241255A1 (Device and method of delivery of a medicament) are hereby incorporated by reference as if fully stated herein.
  • the extracted nicotine oil is complexed with an acid and then mixed with the wax partition.
  • the nicotine salt may also be mixed with glycerin and then mixed with the wax.
  • the acid is complexed with the wax partition to form the salt.
  • Crystallization inhibitors may be employed, including inter alia to avoid precipitation of the nicotine salt when the acid is complexed with the nicotine. Crystallization inhibitors are described in US 20160038406 (Chemically stable and oromucosally absorbable gel compositions of a pharmaceutical active agent in a multi-chambered delivery system), which is incorporated herein by reference as if fully stated.
  • Preservatives may be added to the tobacco wax to preserve freshness and inhibit microbial growth.
  • a pasteurization process step may be employed, inter alia, to prohibit microbial growth.
  • the tobacco may be pasteurized prior to extraction, or the extracted partitions themselves may be subject to pasteurization.
  • the composition maintains a relatively high viscosity and/ or consistency despite the addition of any excipients. It may be advantageous that the tobacco wax composition does not readily flow until under heavy-vaporizing heat. However, it may be beneficial to adjust the rheological properties of the tobacco wax composition. For example, a reduced viscosity and or surface tension may be desired for various reasons, such as packaging convenience (e.g., a squeezable tube may be easier to use with reduced viscosity). The use of PG as a vapor agent may serve this purpose, having a much lower viscosity than vegetable glycerin. Viscosity may be marginally affected by ambient temperature, and some consideration must be given to same.
  • Rheology agents may be employed to adjust the viscosity, surface tension and other rheological properties of the final product.
  • Suitable excipients including film formers, gelling agents, and surfactants.
  • film formers are used 0.01%-20%
  • gelling agents are used 0.01% - 20%.
  • a solvent may be used and then substantially removed as appropriate.
  • Viscosity of one, non-limitative embodiment of the present invention is discussed in Example T below. As discussed in example T, this embodiment presents as a very viscous, non-Newtonian, pseudoplastic (shear thinning) and thixotropic liquid. Viscosity of liquid embodiments is preferably greater than 8000 centipoise, more preferably greater than 10,000 centipoise, and most preferably greater than 12,500 (measured at 2.5 rpm, 25.4 C using Brookfield as per Example T below).
  • a thixotropic and/or pseudoplastic liquid may desired in certain embodiments to provide structure in the composition, and stability of suspension and/or emulsion of other constituents.
  • the resulting wax composition may be used by itself, or mixed with other vaporizable compositions both solid and liquid formats. Such mixing may be done by the manufacturer or by the user.
  • Liquid formats including without limitation e-liquid type products.
  • Solid formats include without limitation other waxes from tobacco or other plant or botanical materials. Mixing can also take place by blending the plant or botanical materials which are subjected to the extraction process.
  • the wax composition of the present invention is intended to be vaporized.
  • Suitable devices include any device capable of sufficiently heating the composition to cause it to vaporize and still not substantially bum the composition.
  • Non-limitative examples of suitable devices include devices marketed as dry herb vaporizers.
  • Suitable temperature ranges for the vaporizer heating element range from temperature needed to vaporize the composition and below the auto ignition temperature of the composition.
  • Cartridge pens vaporizers may be employed.
  • Suitable battery parameters ranging from 1 Amp continuous output to 30 Amp continuous output.
  • the wax composition of the present invention is substantially vaporizable, meaning that it will be substantially vaporized when heated in a suitable device. It is desirable in certain embodiments that residue is minimized, including inter alia to avoid the need to clean the device between uses. Where a pod (including a cartridge) is used, residue is of less concern, since the pod is removable regularly replaced by the user, typically after the pre-filled portion of tobacco wax composition has been substantially or fully used.
  • the tobacco wax composition of the present invention when vaporized, emits lower levels or harmful or potentially harmful constituents (HPHC’s) than conventional tobacco products, e.g. cigarettes.
  • HPHC harmful or potentially harmful constituents
  • the tobacco wax composition when used in a suitable vaporizer, results in less than 25%, on average or for an individual HPHC, of the levels of HPHC’s from a Kentucky reference cigarette (3R4F) (using comparable methods to measure e.g. Health Canada intense method, or ISO 3308:2000, or Massachusetts, or FTC), preferable less than 10% and more preferably less than 5% and even more preferable less than 1%.
  • HPHC’s so measured may include without limitation, each of the 93 costituents identified by US FDA (April 2012) and available at the time of filing at this link:
  • HPHC levels that are substantially below those of the IQOS system with a full flavor Heet, on an individual basis, or taking together as an average, or any average basket of all of, or any group of, the following enumerated analytes (such sole analyte or basket, the“comparator”).
  • Representative HPHC’s may include, inter alia, Acetaldehyde, Acrolein, Acrylonitrile, 4-Aminobiphenyl, 1 -Aminonaphthalene, 2- Aminonaphthalene, Ammonia, Benzene, Benzo[a]pyrene, 1,3-Butadiene, Crotonaldehyde,
  • the tobacco wax composition may yield HPHC levels that are at least 30% lower than IQOS-Heet comparator, preferably, 50% lower, still more preferably 75% lower, and most preferably 90% lower. Such comparisons may be made using any known smoking regime, including ISO 3308:2000, Health Canada intense,
  • toxicants measure below quantifiable limits. It is desirable to mitigate the levels of tobacco specific nitrosamines (TSNAs) in the composition.
  • the tobacco wax composition has TNSA levels preferably less than 10 parts per million (ppm), more preferably less than 3 ppm, more preferably less than 1 ppm, yet more preferably 0.5 ppm and most preferably below quantifiable limits at the limits of quantification described in the examples below. As shown in the examples, when vaporized the emissions of the tobacco wax composition may result in TSNA levels below quantifiable limits.
  • the present invention relates to a portion-sized container (“pod”) of a tobacco wax composition for administration to a mammal or person.
  • the pod is intended for use in a personal (or other) vaporizer.
  • the pod is most commonly in a cup like shape.
  • the top is commonly open, and temporarily covered by a covering that is removed just prior to, or in connection with use of the portion sized container.
  • the portion may be for multiple uses and sessions by the user.
  • the tobacco wax composition portion may range from 1 mg to 3 grams, preferably from 250 mg to 2 grams, most preferably 400 mg to 1.2 grams.
  • the pod is received, or mated to a receiving chamber.
  • the receiving chamber comprises— or is adjacent to— the heating system.
  • the receiving chamber and pod are shaped to maintain close contact, with the absence or substantial absence of air between the two respective surfaces (so the pod surfaces are substantially in contact with the receiving chamber).
  • the PTC ceramic (or comparable receiving chamber material) is composed such that the Curie point discourages or retards heating of the tobacco wax composition above a high (upper) threshold.
  • the receiving chamber itself is a comprised of heating elements.
  • the receiving chamber may be comprised of a bottom heating element which mates to the bottom of the pod, and one or more heating loops that hold in place the higher portions of the pod.
  • the pod is a cartridge which comprises a heating element.
  • High threshold temperatures may be associated with toxicant and degradant production and are to be avoided regardless of the method in which the receiving chamber, pod or cartridge is heated. It is preferable that the tobacco wax composition in the cartridge or pod not be heated to greater than 400°C, preferably less than 350 , more preferably less than 300°C, more preferably less than 275°C, still more preferably less than 240° C. Relatively low temperatures may be employed given the propensity of the tobacco wax composition of the present invention to vaporize. In the preferred embodiment, an upper threshold temperature is not exceeded, or not generally or likely to be exceeded in normal consumer use.
  • An optimal temperature range may be 160° C to 240° C, preferably 180° C to 240°C, more preferably 200° C to 220° C, for certain embodiments of the present invention.
  • the device be capable of rapidly reaching operating temperatures (without overshooting target operating temperatures or exceeding high threshold temperatures), or otherwise sufficient temperatures.
  • the device is capable of heating the tobacco wax composition in the cartridge or pod reach the preferred operating temperature range rapidly, meaning in less than 10 seconds, preferably in less than 3 seconds, more preferably in less than 1 second, and most preferably within .5 second. It is contemplated that substantial vapor can be produced for the user within these time intervals.
  • Example P As shown in Example P, below, a cartridge was able to vaporize the tobacco wax composition very effectively, with“on off’ functionality—meaning there was no discernable time lab from the time the device was activated from inhalation (suction) and the production of vapor.
  • IQOS provides extensive instructions on how to“release any Heatstick fragments” (id). This description of IQOS provides a number of difficulties for a user: the need to wait twenty seconds for the device to reach operating temperature; the need to consumer the entire heat stick within six minutes, need to recharge from the larger battery back (the“holder”) every fourteen puffs.
  • Bottom airflow is the primary design currently used in cigarettes and vapor pens. Bottom airflow directs air directly over the heating coil (where vapor is created). The wick for e-liquid helps to prevent leaking of the e-liquid.
  • Side airflow may enter through the sides of the pod.
  • the pod itself has holes that correspond to side airholes located in the sides of the receiving chamber (and permitting airflow, being connected to the outside of the vaporizer).
  • Such side holes in the pod are covered prior to use (to protect the product), and such cover is removed by the user prior to use or automatically by the device.
  • the device pre-formed airholes
  • a relatively weak material is used that can be readily punctured.
  • the side airflow must enter above the tobacco wax composition product fill level (as distinct from the top of the pod).
  • the product fill level must be calibrated to the location of the side airholes, if any, in the sides of the pod.
  • Side airflow may also enter from the side of the receiving chamber above the top of the pod. Where there are side airholes above the top of the pod, similarly the product fill level is still calibrated to the distance from the product fill to the airholes. If the distance is too short, blockage is more likely. Similarly, if the distance is too long vapor production will be lessened.
  • the side airholes are less than 4 mm from the starting product fill level, preferably less than 2 mm from the starting product fill level, preferably more than .5 mm from the starting fill level, more preferably more than 1 mm from the starting fill level.
  • Side airholes may be directed downwards (i.e. at a downwards trajectory) to increase the air vortices and turbulence.
  • Placement of airhole locations can be oriented to avoid or reduce blockage.
  • the personal vaporizer may be raised to mouth of a user and held parallel to the ground when used.
  • a conventional heat button can be readily used by the thumb or an opposing finger, and is not a good predictor for orientation (although the user will typically have the battery button pointing up or down).
  • the mouthpiece however can be shaped in such a way that is intuitive to the user to orient the vaporizer in a certain direction (as a non-limitative example, a plastic cigarillo tip is typically formed in a way that a user would know how to orient the cigarillo).
  • the side airholes can be oriented such that the airholes are biased to the up-wards plane when the vaporizer is oriented parallel to the ground plane (since we know how the user will orient the vaporizer because of the mouthpiece.
  • three airholes may be used (in the receiving chamber potentially with aligned pod holes) that are positioned with a bias against the downward side (meaning the airholes are biased towards the upward side when the device is uses as expected including through use of a shaped or marked mouthpiece).
  • the vaporizer, pod and/ or receiving chamber may have up to ten side airholes, preferably 2-6 side airholes most preferably 3-5 side airholes. Where a mesh or similar covers the airhole opening, the number of airholes would be understood to be the number of air channels.
  • the device may similarly be marked or shaped on a part of the device other than the mouthpiece to indicate a desired orientation (with corresponding placement of airholes as described above to reduce blockage potential).
  • shape indentations may be provided to signal a desired holding of the device in the hand.
  • the pod has a diameter of 3-15 mm, preferably 6-10 mm (with a corresponding internal diameter for the receiving chamber).
  • the pod has a height of .5 to 22 mm, preferably 2 to 10 mm (with a corresponding size for the receiving chamber).
  • the pod itself may comprise the heating chamber, optionally including the heating element as a component of the pod. While this embodiment may be more costly to manufacture (as compared with a pod that merely mates with a heating chamber), such embodiment offers the advantage of providing a fresh heating elements with each pod. Such advantage may be associated with increased puff consistency since degradation of the heating element is avoided through less use (i.e. replacement or substantial replacement with each new pod).
  • Heated tobacco wax compositions in a pod can be explosive (in terms of physical motion— not ignition) when wax at the bottom of a pod is vaporized, and the vapor pressure is such as to disrupt the wax above to allow the vapor to escape.
  • a“shield” a physical obstruction that prevents direct passage of heated tobacco wax composition material from the pod or cup to the mouthpiece.
  • the shield is attached to the mouthpiece (but it may equally attach to other parts of the vaporizer).
  • the shield may also employ features intended to increase airflow turbulence, without adversely affecting the user’s“draw” on the vaporizer.
  • the Pod may similarly be designed to minimize the possibility of wax explosions. For example (and without limitation), a rim or brim on the pod may act in the same manner as the shield to obstruct wax explosions from traversing the mouth piece.
  • the pod-receiving chamber may have a rail, slot or comparable alignment interface to ensure the pod is appropriately aligned in the receiving chamber, including for other reasons, so that the airholes from the receiving chamber align or substantially align with the pod airholes.
  • the pod has complimentary features to mate with the alignment interface.
  • alignment may also be used for other purposes, i.e. to facilitate other connections between pod and receiving chamber (e.g. data link, ejector system, etc).
  • the vaporization device may have an ejection system to facilitate ejection of the pod from the receiving chamber (as opposed to relying upon shaking or use of inertia to evacuate the pod).
  • Such system may comprise, without limitation, a physical ejector to lift the pod out of the receiving chamber.
  • a mouthpiece sits above the pod-receiving chamber assembly.
  • the mouthpiece employs a combination of distance and relatively low heat transfer properties to ensure the mouthpiece is not uncomfortably warm for the user.
  • the mouthpiece may be integrated with a shield and/ or a device to increase turbulent airflow.
  • a sleeve designed to ease cleaning of the mouthpiece. Wax may form on the inside mouthpiece during use of the material, either from explosion of wax or from condensation of materials. Such remainder wax may be unsightly and require manual cleaning.
  • a sleeve may be shaped such that it adheres or substantially adheres to the mouthpiece.
  • the sleeve may be disposable, allowing a user to simply dispose of the sleeve (rather than cleaning the mouthpiece), akin to a disposable coffee filter.
  • the sleeve may comprise any suitable material, including without limitation, a paper, pressed paper, cardboard, a cellulosic, or other suitable material.
  • the selected material for the sleeve should resist formation from air vortices, or from trapped wax or condensate.
  • the sleeve material may be coated. Coatings may be designed (and sleeve materials selected) to resist adhesion of wax (to encourage the adhered material to drop back to the heating chamber), or to encourage adhesion. Encouraging adhesion may useful to avoid contact of the user with condensate when removing the sleeve.
  • the sleeve may be absorbent to better catch the wax or condensate.
  • a reusable sleeve may also be employed in certain embodiments.
  • the sleeve may be removed, cleaned, and replaced.
  • any suitable material may be employed that can be readily re-used.
  • the mouthpiece For embodiments for which the mouthpiece can be used with a sleeve, the mouthpiece must be capable of being easily placed into the mouthpiece, as well as capable of being readily released by the user for disposal or cleaning.
  • a latch or locking mechanism may be employed.
  • the sleeve is held in place by simple screwing the mouthpiece onto the heating chamber.
  • the sleeve can be released in less than 5 seconds by the user, preferably in less than 2 seconds, most preferably in less than one second.
  • the sleeve may be any suitable color.
  • a shade of brown may be used to better mask the appearance of the adhered or trapped wax.
  • dark colors are preferred.
  • the pod itself may be fashioned from a material that heats, e.g. a PTC ceramic. Other materials may also be used that heat when electric current is supplied.
  • the receiving chamber acts as a physical receiving area, may provide airflow (airholes) and may integrate power to the pod.
  • the pod may further comprise a thermistor to measure temperature, either of the pod itself or wax contained therein.
  • Empty pods may also be offered to allow the user to treat the device as an open system (meaning they can use their own vaporizable materials).
  • the pod may be made from any suitable material. Special care must be given that the pod material does not emit undesirable elements when heated.
  • the material will generally be a solid material, but flexible materials may also be employed.
  • a flexible bladder or chamber may be employed. In certain embodiments this flexible bladder may assist to promote flow of the tobacco wax composition towards the heating element.
  • a pod with a flat or substantially flat bottom surface is desirable for handling by the consumer, other shapes may be used. Specifically, a shape whereby the cup is half a circle will mean reduce mean geographic distance from the receiving chamber walls. Other shapes can be selected with this same purpose, i.e. to reduce geographic distance. Corners may, ceteris paribus, create higher heat areas within the tobacco wax contained in the pod.
  • the pod may be integrated with the sleeve function.
  • the pod may be in the shape of a circular cauldron— which is heated— connected to an upper conical shape that prevents the mouthpiece from getting wax or wax condensate adhered.
  • the pod may be comprised of multiple materials— the lower portion designed for heating, and a separate upper material that is designed to function as a sleeve.
  • it may be desirable to have a separating material between the heatable portion of the pod and the sleeve portion. It in cases where adequate power is available, the design may allow the sleeve to heat.
  • a v-shape may be used to flow wax towards the heating element.
  • v- shape we refer to the use of slope to employ gravitational flow of the tobacco wax composition.
  • the top of the pod is covered with a porous layer which remains on top of the pod during use.
  • This porous layer is sufficiently porous to allow for transmission of sufficient vapor for the user.
  • the porous layer is similarly sufficiently porous not to interfere or prevent a desired pressure drop.
  • the pressure drop of the device used to vaporize the tobacco wax composition, inclusive of the pod if any will have a pressure drop of 20 (mm H20) to 175 (mm H20), preferably 75 (mm H20) to 130 mm (H20), most preferably 90 (mm H20) to 110 (mm H20). Pressure drop is measured using Coresta Guide No. 4, or other accepted method for measuring pressure drop.
  • the porous layer is sufficiently non-porous to prevent (or substantially prevent or partly prevent) parts of the wax composition from exploding upwards and escaping from the heating chamber to whence they may adhere to the mouthpiece.
  • the porous layer may be made from any suitable material.
  • a thermo- conductive material is used, such that the permeable layer. Thermo-conduction may be used to encourage parts of the wax composition that are caught or trapped on the permeable layer to drip off and re-join the wax composition in the heating chamber (and/ or themselves be vaporizer).
  • the porous layer may be selected or coated so as to resist adhesion of wax composition components to the layer.
  • the porous layer includes heating element(s).
  • the top of the pod is covered with two layers.
  • the outer layer is an impermeable or semi-impermeable layer for barrier purposes (i.e. product stability and freshness) (a “barrier layer”). Underneath the outer layer is the porous layer which remains on during use.
  • porous materials akin to those described for the porous top layer, may be used to cover side-holes or other airholes.
  • the top of the pod may be configured to allow for easy access by a consumer. This allows a consumer to add other waxes or extracts to the Pod. Conversely, the system may be configured to make it difficult for a consumer to add their own materials to the pod.
  • a temperature meter can be built into the pod (including without limitation a cartridge), the receiving chamber, or both.
  • the pod and receiving chamber are used as part of a vaporizing system, further comprising a power source (typically electric, but it may also be a carbon-based source, or butane based source or other source of heat), and a control module that allows the user to select heat settings, turn the device on or off, as well as other features.
  • the device may be able to store and communicate use data.
  • a temperature meter in a cartridge may be particularly useful for embodiments that employ a warming cycle as discussed below.
  • the Pod may be able to communicate to the device (or the device determine from the Pod) the type of Pod (flavor, quantity of tobacco wax composition, nicotine strength, etc). It will be appreciated that the use of a Pod will give additional flexibility to the wax composition formulation, because non-vaporizable ingredients may be used in the composition without leaving the non-vaporizable ingredients as residue that require cleaning by a user. Film formers or molasses (and other sugars and sweeteners) are non-limitative examples of non-vaporizable ingredients that may be employed.
  • the use of the pod is not limited to tobacco wax compositions but may also be employed with other botanical or plant wax compositions, as well as e-liquids. Such materials may be used in combination with tobacco wax. References herein to tobacco wax compositions can also refer to these products and compositions comprising them.
  • One potential negative with the pod may be the availability of too much tobacco wax composition for vaporization when vaporization temperature is reached, particularly where the temperature is not effectively controlled. This can result in puffs where are too strong— both organoleptically and also unequally. Unequally meaning a variance in strength and emissions puff to puff. Generally speaking, such variance is undesirable.
  • the tobacco wax composition may be coated on a heated rod, or other substrate.
  • the direct contact with the heated rod (or other substrate) allows for rapid heating.
  • the substrate may be shaped as a rod, or other shape (for example, and without limitation, a rectangle, folded rectangle)
  • the pod may use a matrix material to trap the tobacco wax composition.
  • a matrix material may be metal or non-metal.
  • an organic or synthetic cotton is used that can trap the tobacco wax composition. As the tobacco wax composition is heated, and becomes flowable, it leaves the cotton and is available for vaporization.
  • the use of a matrix in the pod (or other chamber, such as a cartridge) may be useful in certain embodiments to promote puff to puff consistency (i.e. reduce puff strength variability). Obviously, it is important that the matrix material does not leach impurities into the tobacco wax composition.
  • a metal matrix may be desirable for heat transfer.
  • the tobacco stick (comprising reconstituted tobacco) requires airspaces in the reconstituted tobacco stick to allow for the aerosolized components to travel from the reconstituted sheet and out through the mouthpiece.
  • air spaces absent, and the tobacco stick comprised of a solid reconstituted plug it would be extremely difficult (and require substantial heat) to force the aerosol through the solid plug.
  • only components on edge of a solid plug would successfully vaporize. This can be seen as analogous to oral thin film casting, wherein water can get trapped in a polymeric matrix and become difficult to remove through heating.
  • the IQOS device has an operational temperature of 350 C; in contrast the GLO uses has a lower operating temperature of 240° C.
  • This difference in operating heating temperatures can likely be explained by the different heating configurations of the two devices.
  • IQOS employs a flat, thin, heated blade or knife upon which the tobacco stick is impaled. The knife does not reach the outer edges of the heat stick (tobacco stick) (otherwise it would destroy the tipping paper on the outside of the tobacco stick). Approximately, it can be thought of as having the width of .8 of the tobacco stick.
  • This greater surface heating area (again assuming identical lengths) likely explains in part the lower operating temperature of the GLO system.
  • Heat transfer by air convection is an essential component of both IQOS and GLO.
  • the tobacco wax of the composition has no or substantially air spaces. In various embodiments, it is a solid, semi-solid or viscous liquid. All of these embodiments substantially lack air spaces.
  • the tobacco wax composition has efficient heat transfer attributes. Glycerin and propylene glycol both have excellent heat transfer properties (sufficiently good for use in anti-freeze systems), as does the tobacco wax itself.
  • the tobacco wax composition is heated in preferred embodiments with the absence or substantial absence of air convection to heat the tobacco wax composition.
  • the tobacco wax composition of the present invention has a thermal conductivity at 300k (80.3 F) of greater than .1, preferably greater than .2, more preferably greater than .25 (W/m K).
  • the substantial absence of air in the tobacco wax composition may also serve to prevent or reduce oxidation when the tobacco wax composition is heated.
  • the relatively low vapor production of reconstituted tobacco heat bum products may be improved by the addition of tobacco wax and/ or tobacco wax compositions to the reconstituted sheet.
  • the tobacco wax and/ or tobacco wax compositions may be added to the matrix prior to casting or creating the reconstituted sheet, or added to after the reconstituted sheet is formed.
  • the tobacco wax composition may be positioned in a product separately from the reconstituted tobacco.
  • a cigarette form may comprise a tobacco wax composition, and separately, a plug of reconstituted tobacco.
  • the lower temperatures needed to vaporize tobacco wax compositions may be desirable here to produced effluent vapor while the reconstituted sheet is still in warm up phase.
  • tobacco wax compositions can be used with separately contained liquids, akin to BAT’s iFUSE product.
  • the pod is a cartridge that optionally comprises its own heating element.
  • a cartridge may employ a filter to avoid any (or substantially any) droplets of the composition from inadvertent inhalation.
  • the pod including without limitation a cartridge may use a low energy substrate for product contact areas.
  • the substrate may be used for all product contact areas, substantially all, or part of product contact areas.
  • Preferred substrates include FEP and PTFE.
  • the substrate must be capable of handling the heat in the cartridge (or pod) without degradation, or with minimal degradation. Leaching is to be avoided.
  • the surface energy of the substrate used for product contact is less than 24 Dynes/ cm, preferably less than 22 Dynes/ cm, more preferably less than 20 Dynes/ cm, and most preferably less than 19 Dynes/ cm.
  • Such low energy substrates may also be desirable for use in connection with product contact areas (or potential contact areas) of other heat not burn products, such as systems using a solid reconstituted tobacco matrix like IQOS, GLO or comparable systems, to reduce or eliminate undesirable sticking of the tobacco matrix.
  • heating of the tobacco wax composition is employed to reduce adhesion, including without limitation in certain embodiments in conjunction with a low surface energy substrate for product contact areas.
  • Such heating preferably heats the tobacco wax composition being stored in the cartridge or other container (i.e. apart from the heating element).
  • the tobacco wax composition is heated to 30 C or above, preferably to 45 C or above, more preferably to 55 C or above.
  • Such heating may occur via thermal conduction from the heating element in regular use.
  • the cartridge may be designed to encourage such thermal conduction, including inter alia through the use of a cartridge (or pod) material with suitable thermal conduction properties.
  • a non-limitative example is an aluminum cartridge with a low energy substrate coating the product contact areas. Other metals, and other thermal conductive materials may be used for this purpose.
  • a secondary cartridge (or pod) heating element may be employed to reach desired temperatures for the tobacco wax composition in the chamber.
  • the secondary heating element may be a filament, foil or other form that runs through the cartridge since the primary purpose of the secondary heating element is to warm the tobacco wax composition, as opposed to the primary heating element (which is intended to vaporize the composition).
  • the secondary heating element may comprise a foil, a filament, or other known form.
  • the secondary heating element may also be placed on the receiving chamber of the device which accepts the cartridge or pod. The secondary heating element may turn on when the primary heating element is used, or may have a heating separate logic (e.g. a warming cycle).
  • the separate logic can include a warming cycle associated with each and any of, or any combination of: turning on the vaporization device, an initial puff, and then repeated after a series of puffs, repeated after a time period (e.g. sixty seconds, ninety seconds, one hundred eight seconds, three minutes, or five minutes), or repeated based on a multiple factors (e.g. puffs and time, or other factors like ambient temperature, temperature of the primary heating element, temperature of the secondary heating element, temperature within the cartridge, or temperature of the receiving chamber).
  • the logic of the warming cycle will be intended to be functional, to encourage flow of the tobacco wax composition towards the heating element, without unduly and unnecessarily draining battery power.
  • the secondary heating element heats vaporized tobacco wax composition vaporized by the primary heating unit to promote flow of the vaporized tobacco wax composition.
  • One advantage of placing the secondary heating element on or in the receiving chamber of the vaporization device is to eliminate the cost of placing a secondary heating element in each cartridge.
  • a typical heating duration for a heating cycle of the secondary heating element is 1 to 40 seconds, preferably 15 to 30 seconds, most preferably 17 to 22 seconds. Applicants have found a 20 second cycle works well for a particular embodiment where the secondary heating element is place on the receiving chamber.
  • a warm up cycle may also be used when the device is first turned on, typically 1 to 10 seconds, preferably 2 to 4 seconds, where the warm up cycle is performed by the primary heating element (a “primary heating element warm up cycle”) .
  • a warm up cycle may also be used when the device is first turned on, typically 1 to 10 seconds, preferably 2 to 4 seconds, where the warm up cycle is performed by the secondary heating element (a“secondary heating element warm up cycle”).
  • Cycles may vary between the primary heating element, and secondary heating element. Said cycles may overlap or happen at different times.
  • the secondary heating element preferably warms the tobacco wax composition in the cartridge (or pod) to above 35 C, preferably above 45 C, and most preferably above 55 C. A preferred range is 40 to 55 C. The intention is to increase flowability, without excessive heating which is associated with unneeded power use and potentially flashes off volatile constituents prior to desired consumption.
  • the secondary heating element may be shaped as half-circular loop, may be rectangular, or contain“turns” or angles that tend to increase overall length of the heating element and thus increase contact surface area of the secondary heating element.
  • the secondary heating element divides into two symmetrical or semi-symmetrical loops on either side of the air tube from the primary heating element, allowing the secondary heating element to loop around or clear, a central airtube.
  • the secondary heating element is part of the vaporization device found in the vaporization device’s receiving chamber to heat the tobacco tax composition in the cartridge or pod.
  • the secondary heating element heats the tobacco composition in the cartridge or pod via thermal conduction, including, by direct conduction.
  • the secondary heating element is in the cartridge, the secondary heating element is longer than one cm, preferably longer than 1.5 cm, most preferably longer than 2 cm.
  • the secondary heating element is wider, at its widest point than 0.025 cm, preferably wider than 0.05 cm, more preferably wider than 0.1 cm, and even more preferably wider than 0.15 cm. Width will, inter alia, increase the contact surface area of the secondary heating element.
  • the surface area of the secondary heating element is from 0.05 sq. cm to 0.6 sq. cm.
  • the dimensions of the heating element may be larger, with a surface area from .05 sq. cm to 3.5 sq cm, preferably .4 to 2.5 sq cm.
  • the secondary heating element provides insufficient heating power to substantially vaporize, or vaporize at all, the tobacco wax composition. See item 29 of Figures 14 and 15.
  • the temperature of the secondary heating element is controlled with an upper bound and optionally lower bound in certain embodiments.
  • the secondary heating element reaches an operating temperature of less than 125C, preferably less than 100 C and most preferably less than 80 C.
  • a temperature range of 70 to 90 C is a preferred range of temperature for the secondary heating element, particularly where the secondary heating element is located in the receiving chamber of the vaporization device (lower temperatures being required where the secondary heating element is located within the cartridge or pod itself).
  • Maximum temperature (and minimum operating) temperature may be controlled using various methods including inter alia, pulse-width modulation.
  • the secondary heating element uses a power of 1 to 4 watts, preferably 1.5 to 3.5 watts, more preferable 2.75 to 2.25 watts. Applicants found that 2 watts worked well in certain prototype embodiments.
  • the secondary heating element will produce heat in the range of 20 to 90 Joules per heating cycle, preferably 30 to 50 Joules per heating cycle.
  • the secondary heating element may comprise one or more heating elements.
  • the secondary heating elements may comprise two separate heating elements in or in the receiving chamber that“sandwich” the cartridge from opposing sides.
  • multiple heating elements are used for the secondary heating element (such multiple elements being understood to comprise a single secondary heating element for purposes of understanding this disclosure).
  • Total resistance for the secondary heating element may range in certain embodiments from 1 to 5 Ohms, preferably 1.5 to 2.75 Ohms, most preferably 1.8 to 2.2 Ohms. Applicants have found 2 Ohms to function well in certain embodiments. As noted in the preceding paragraph, such total resistance may be the total resistance from a multiple heating element configuration.
  • Various materials are suitable for use as the secondary heating element. A non-limitative list includes the group of ceramics, kapton, khanthal, and nichrome. Composites may also be used.
  • Thermal conductivity (often denoted k, l, or K) is the property of a material to conduct heat. It is evaluated primarily in terms of the Fourier's Law for heat conduction. In general, thermal conductivity is a tensor property, expressing the anisotropy of the property.
  • Heat transfer occurs at a lower rate in materials of low thermal conductivity than in materials of high thermal conductivity.
  • materials of high thermal conductivity are widely used in heat sink applications and materials of low thermal conductivity are used as thermal insulation.
  • the thermal conductivity of a material may depend on temperature. The reciprocal of thermal conductivity is called thermal resistivity.
  • Thermal conductivity can be used to warm the portion of the tobacco wax composition that is not being vaporized, to promote flow. Thermal conductivity may be employed irom the primary heating element, secondary heating element, or from a heating element in a charging device.
  • Thermally conductive materials may be used in whole, m part, or substantially to comprise the airtube. Thermally conductive materials may be used in whole, in part, or substantially, to comprise the cartridge or pod, including surfaces in contact with the tobacco wax composition or other contained material. Fibers, filaments, or a lattice of thermally conductive materials may be part of the cartridge.
  • One advantage of such approach is to warm the tobacco wax composition without additional energy needs.
  • Selected materials may have a thermal conductivity value— a k value (W/m K) of greater than 35, preferably greater than 70, more preferably greater than 110, most preferably greater than 150.
  • Item 31 of Figure 16 shows a receiving chamber made from a thermally conductive material, optionally copper, to transmit heat trom the secondary heating element to the cartridge and tobacco wax composition contained therein.
  • an airtube may be made partially trom a highly thermo conductive material, with a less thermo conductive material near the top ot the mouthpiece.
  • a warming cycle may be used with the product is not in use to encourage flow of the tobacco wax composition towards to the heating element.
  • a warming cycle may be used in one non- limitative embodiment, an external vaporizer charger unit holds the vaporizer in a vertical (or near vertical) position, and performs one or warming cycles to encourage flow of the tobacco wax composition down and towards the primary product heating element (located at the bottom end of the chamber).
  • the charger device has a separate heating element (separate from the heating element(s) in the vaporizer itself) that uses a warming cycle or cycles to encourage flow of the tobacco wax composition, optionally during the charging cycle.
  • the warming cycle may take from 1 second to five minutes, preferably 2-4 minutes.
  • vibration or wave energy may be employed to encourage flow.
  • tobacco wax composition utilization we mean the percentage of the tobacco wax composition that is successfully vaporized. As demonstrated in Example Q below, with standard plastics, the tobacco wax composition utilization was relatively low at approximately 66%. Using suitable materials, we teach a tobacco wax composition utilization rate of greater than 75%, preferably greater than 80%, more preferably greater than 90%, and most preferably greater than 95%.
  • Texture may also be employed in cartridge (or pod or other container) to encourage flow of the tobacco wax composition.
  • the use of texture to facilitate flow is described as the“Lotus Effect.” Lai’s“Mimicking Nature: Physical basis and artificial synthesis of the Lotus Effect” (2003) (available at: https://web.archive.Org/web/20070930222543/http://home.wanadoo.nl/scslai/lotus.pdi) is hereby incorporated by reference as if fully set forth herein. Additionally,
  • a certain width is desirable to promote flow the material.
  • an internal width meaning, a width measured from the inside surface edge across to the opposite inside surface— in certain embodiments is greater than .75 cm, preferably greater than .85 cm, more preferably greater than .95 cm, and most preferably greater than 1.05 cm.
  • the secondary heater is adhered, or substantially adhered, or part of the inside wall of the cartridge.
  • the secondary heater contact area itself has a low surface energy, as discussed in this application, to promote flow.
  • compositions other than tobacco wax including inter alia any botanical wax or botanical oil.
  • Figure 1 is a perspective view showing a ll heating chamber containing a 10 tobacco wax composition. The outside of the heating chamber assembly is 12. In certain preferred
  • the tobacco wax composition is in a pod.
  • FIG 2 is an exploded perspective of the heating chamber sub assembly, including a ceramic heating chamber 11, which may contain a pod or may comprise itself a pod.
  • the 13 heating element may be printed or coated onto the heating chamber, which in preferred embodiments in ceramic.
  • 12 is the wall of the heating chamber casing.
  • 14 is an air flow slot for the heating chamber or pod receiver.
  • 15 is an airhole in the heat chamber or pod receiver (other airhole figurations may be employed in different embodiments).
  • 16 is an electrode insulator.
  • 17 is the electrode.
  • 18 is the mouthpiece screw thread.
  • Figure 3 is a cross-sectional view of the heating chamber containing a tobacco wax composition. 10 is the tobacco wax composition; other numbers are as above.
  • Figure 4 is a cross section of the wall of the 12 heating chamber casing.
  • Figure 5 is a cross section of the receiver for the heating chamber or pod, including the battery connection section. 19 is the battery screw thread.
  • Figure 6 is a cross section of the 17 electrode.
  • Figure 7 is a cross section of the 16 electrode insulator.
  • Figure 8 is a perspective view of a pod (or heating chamber) showing a 13 printed or coated heating element and 20 positive and 21 negative electrical contacts.
  • Figure 9 is an exploded perspective view of a 11 pod, a 23 porous layer, and a 22 barrier layer.
  • Figures 10-13 show an alternative embodiment using a cartridge having a secondary heater.
  • Figure 10 is a perspective view of a cartridge. 24 is the top of the cartridge.
  • Figure 11 is a cross section of a cartridge, showing a secondary heater that is adhered to the internal surface of the cartridge.
  • 26 is an area that may contain a filter to prevent droplets from transiting to the user.
  • 27 is the airtube.
  • 25 is the secondary heater that is flush with the internal sides of the cartridge.
  • Figure 12 is a cross section of a cartridge, showing a secondary heater that extends into the cartridge’s reservoir. 25 is a secondary heater with“turns” that is spread through the cartridge reservoir.
  • Figure 13 is a cross section of a cartridge. 28 is a thermally conductive material on the walls of the cartridge that conducts heat from the primary, vaporizing heating element.
  • the secondary heater can be provided on the receiving chamber for the cartridge, where the receiving chamber is optionally a fixed part of the vaporization device.
  • Figure 14 is a bottom view of a receiving chamber for a cartridge, where the receiving chamber is optionally a fixed part of the vaporization device. 29 is a secondary heating element intended to warm the cartridge (not to vaporize the cartridge contents). 30 is a transparent window allowing the user to visually inspect the amount of vaporizable composition, where the cartridge itself is transparent at the place of 30. The cartridge can be inserted into the receiving chamber from the end of the receiving chamber shown at the bottom of Figures 14-16.
  • Figure 15 is a top view of a receiving chamber for a cartridge, where the receiving chamber is optionally a fixed part of the vaporization device. 29 is a secondary heating element intended to warm the cartridge (not to vaporize the cartridge contents) .
  • Figure 16 is a perspective view of a receiving chamber for a cartridge, where the receiving chamber is optionally a fixed part of the vaporization device. 29 is a secondary heating element intended to warm the cartridge (not to vaporize the cartridge contents).
  • the receiving chamber is comprise of a thermally conductive materials (31), optionally copper.
  • the tobacco wax composition is contained and bounded by the pod shape, or otherwise by the heating chamber.
  • it When used in a device, it typically comprises no substrate, paper or tipping paper. This absence distinguishes the product from typical heat not burn products like IQOS or GLo.
  • Tobacco wax was removed from tobacco leaf using supercritical C02 extraction. Tobacco oil was mixed in with the wax, while retaining a wax consistency. The material was fragrant and dark brown in color. A nicotine assay indicated a nicotine strength for the tobacco wax of 4%. The wax was placed in a dry herb vaporizer and vaped by a healthy adult male. The tobacco wax vaporized creating a nice vapor volume. The nicotine delivery was strong and the product was fragrant with tobacco fragrance. The tobacco wax substantially vaporized leaving minimal residue on the heating coil.
  • Example A The tobacco wax of Example A was taken and 10% of vegetable glycerin and 5% of propylene glycol (measuring by weight of the final composition) was added. The tobacco wax accepted the addition of these vapor agents. The resulting composition was placed in a dry herb vaporizer and used by a healthy adult male. The flavor was excellent and the vapor production was increased from Example A.
  • Example A The tobacco wax of Example A was taken and grape flavor from Tobacco Technology, Maryland was added, at 3.5% of the composition.
  • the resulting tobacco wax composition was placed in a dry herb vaporizer and used by a healthy adult male. The grape taste was enjoyed by the user.
  • Tobacco wax was extracted from a different of blend tobacco leaf using supercritical C02 extraction.
  • the tobacco wax was dark with a slightly green tinge.
  • the nicotine content of the tobacco wax was approximately 1.5%.
  • Nicotine glycerin solution (10%) was added to 10% of the final composition weight.
  • the product vaped well but the flavor notes where not as attractive as the tobacco wax of Example A. It was observed that additional flavors could improve the product.
  • Example D Oil from the extraction of tobacco described in Example D was added to the tobacco wax of Example D, and the composition was mixed using strong shear forces. The resulting product vaped well and left very little residue.
  • Tobacco wax from Example A was placed in a vaporizer.
  • a small amount of zero nicotine flavored e-liquid was added to the vaporizer.
  • the two were not otherwise mixed other than to insert them together.
  • the wax and the zero were vaporized together.
  • a fair amount of residue was left by this mix in the vaporizer.
  • the exercise was repeated with a yet smaller amount of e-liquid with improve results including much less residue.
  • Tobacco wax from Example A was compounded with a small amount of sodium carbonate as a buffer agent to affect a more basic plT.
  • Tobacco wax was extracted from flue cured tobacco with low TSNA levels. The extraction was performed using supercritical C02 extraction. The wax partition was approximately 4% of the mass of the starting tobacco. Tobacco wax was also extracted from burley tobacco with low TSNA levels, again using supercritical C02 extraction, and again with a yield of approximately 4%.
  • Example El The tobacco wax partitions of Example El were blended, at a ratio of 70% flue cured to 30% burley. The combined wax partition was then mixed with vegetable glycerin, for a final composition of 50% tobacco wax, and 50% vegetable glycerin.
  • Example I The final composition of example I was sent to a third party laboratory for nicotine testing.
  • the composition was measured to contain 3.3% nicotine, implying that the blended wax partition had a starting nicotine level of 6.6% (prior to dilution with vegetable glycerin).
  • LOQ for the testing was 0.16%.
  • Example I The final composition of Example I was sent to a third party laboratory for emissions testing.
  • the smoke regime for the above testing was: 55mL puff/ 30 sec interval/ 3 sec duration.
  • the composition was vaporized in a vaporization pen, on high heat.
  • the basis for this surprising result may reflect in part reduced energy requirements to volatilize the tobacco wax compositions of the present invention, as compared to the energy requirements needed aerosolize the components contained in the solid matrix which is the reconstituted tobacco comprising the Heat Stick used in IQOS.
  • below quantifiable limits indicates that no amount of the analyte exists above the limit of quantification.
  • the analyte is understood to exist at a level ranging from zero to less than the quantifiable limit.
  • Example M Polysorbate (Tween 20) was added to the composition of Example I, and the resulting composition was placed in 5 ml tubes, alongside of 5 ml tubes filled with the composition of I. It was noted that the addition of polysborbate substantially reduced separation of the vegetable glycerin from the tobacco wax.
  • Tween 20 Polysorbate
  • the blend was particularly pleasant, offered excellent tobacco flavor and rich tobacco satisfaction.
  • a healthy male volunteer took a Ploom Model 2 device, and removed the tobacco from the product’s pod, and replaced this tobacco with the tobacco wax composition of L.
  • the Model 2 was then started in accordance with its directions.
  • the Model 2 has a thirty second warm up period, and reaches an operating temperature of 175 C/ 347 F.
  • the tobacco wax composition violently vaporized during the warm up phase (the indicating light blinks during said phase), and bubbled out of the mouthpiece.
  • the inventors attributed the ability of the tobacco wax vaporization to be readily vaporized— using on-off heating (as opposed to a prolonged warm up stage— meaning a warm up stage taking over 3, 4 or 5 seconds).
  • This example relates to vaporization temperature testing.
  • the sample tested was made as follows. The wax and oil partitions from supercritical fluid (C02) extraction of Flue Cured tobacco were combined. The wax and oil partitions from supercritical fluid (C02) extraction of Burley Tobacco were combined. The result was a very viscous, if flowable liquid. These two were mixed in a ratio of 70:30 (seven parts flue cured to three parts burley).
  • This mixture was in turn combined with vegetable glycerin in a ratio of 50:50 (one part of tobacco mixture to one part of vegetable glycerin).
  • a simple closed pod system was filled with the tobacco wax composition.
  • Testing equipment included a Digital Multimeter (Rigol DM 3068), a temperature sensor (PT100A), a brass steamer, and Mathlab software. With approximate 5 watt power, some burning was observed. With power reduced to 3.5 watt, the system product very thick vapor without burning. The system was able to produce good vapor at 1.7 watt.
  • the power for a tobacco wax composition vaporizer is preferably 1.25 to 4 watts, more preferably
  • Vapor production began at 160 C.
  • Thicker vapor began at 200 C.
  • the viscosity of the tobacco wax composition reduced under heat. Reduction was observed starting at 30 C, with greater effect noted at 45 C.
  • Example P involved a series of tests using the tobacco wax composition of Example O.
  • This tobacco wax composition was placed in a plastic cartridge similar to the JUUL system sourced from American Wholesale Vapor, Shenzhen China.
  • the cartridge was able to vaporize the composition very effectively, with“on off’ functionality—meaning there was no discemable time lab from the time the device was activated from inhalation (suction) and the production of vapor.
  • sticking of the tobacco wax composition was observed, which resulted on amounts of the tobacco wax composition sticking to the cartridge and failing to vaporize.
  • the tobacco wax composition is strongly adherent to each surface at room temperature regardless of surface energy. At room temperature, adhesion is strong, even on Teflon. Delrin, a polyoxymethylene polymer, also showed adhesion at room temperature.
  • PTFE is polytetrafluoroethylene.
  • FEP is fluorinated ethylene propylene.
  • PFA is perfluoroalkoxy copolymer.
  • ETFE is (ethyl ene-tetrafluoroethylene) .
  • Solid plates of FEP and PTFE were purchased and heated on a heating block with noticeable change in tobacco wax composition adhesion. From visual assessments, 45 C appeared to be a minimum sweet spot for FEO and the tobacco wax composition (to reduce adhesion).
  • a low surface energy substrate may be used to in a cartridge (or pod or other container) to reduce adhesion of the tobacco wax composition.
  • the lower energy substrate is less than 24 Dynes/ cm, preferably less than 22 Dynes/ cm, more preferably less than 20 Dynes/ cm, and most preferably less than 19 Dynes/ cm.
  • heating of the tobacco wax composition is employed to reduce adhesion. Such heating preferably heats the tobacco wax composition being stored in the chamber (i.e. apart from the heating element).
  • the tobacco wax composition is heated to 30 C or above, preferably to 45 C or above, more preferably to 55 C or above. Heating the tobacco wax composition to promote flow, together with a low energy substrate, can encourage flow and allows for high efficiency of tobacco wax composition utilization from a cartridge.
  • tobacco tax composition utilization we mean the percentage of the tobacco wax compostion that is successfully vaporized. As demonstrated in Example Q below, with standard plastics, the tobacco wax composition utilization was relatively low. Using suitable materials, we teach a tobacco wax composition utilization rate of greater than 75%, preferably greater than 80%, more preferably greater than 90%, and most preferably greater than 95%.
  • Texture may also be employed in cartridge (or pod or other container) to encourage flow of the tobacco wax composition.
  • the use of texture is described as the“Lotus Effect.”
  • This example demonstrates tobacco wax composition utilization using a standard cartridge, similar to JUUL system sourced from American Wholesale Vapor, Shenzhen China.
  • the cartridge was filled with the tobacco wax composition of Example P.
  • the amount of tobacco wax composition added to the cartridge was measured at 900 milligrams.
  • a healthy adult volunteer used the cartridge over a period of three days, to the point at which the cartridge would no longer produce substantial vapor.
  • the cartridge was weighed again to determine the residual tobacco wax composition that failed to vaporize, and that amount was calculated to be
  • the tobacco wax composition was placed in an aluminum foil substrate, and it was attempted to be lit using a long-necked butane lighter (commonly used for bbq use). Despite holding the flame in contact with the tobacco wax composition for periods of up to thirty seconds, no propensity for combustion was observed.
  • the tobacco wax composition could but be ignited or lit with a butane lighter (“non-combustible”).
  • Sample is non-Newtonian, pseudoplastic (shear thinning) and thixotropic. It was noted that the condition of being thixotropic is desirable, in certain embodiments, for stability of the emulsion. It was also noted that the condition of being pseudoplastic, was similarly desirable for the stability of the emulsion and/or suspension.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Manufacture Of Tobacco Products (AREA)

Abstract

L'invention concerne des compositions de cire de tabac appropriées pour être utilisées dans un vaporisateur. La cire de tabac peut comprendre des excipients supplémentaires comportant des agents en phase vapeur, des agents de pénétration, des agents tampons et des agents rhéologiques. La composition contient de la nicotine. La composition de cire de tabac laisse un minimum de résidus dans le vaporisateur lorsqu'elle est utilisée. Selon un autre aspect, l'invention concerne un récipient de conditionnement unitaire (« dosette ») d'une composition de cire de tabac destinée à être administrée à un mammifère ou à une personne. La dosette est destinée à être utilisée dans un vaporisateur personnel (ou autre).
PCT/US2019/022417 2018-03-16 2019-03-15 Compositions de cire de tabac vaporisables et récipient associé WO2019178448A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP19767298.3A EP3764823A4 (fr) 2018-03-16 2019-03-15 Compositions de cire de tabac vaporisables et récipient associé
CN201980032310.2A CN112566519A (zh) 2018-03-16 2019-03-15 可汽化的烟草蜡组合物及其容器
US16/981,210 US20210007389A1 (en) 2018-03-16 2019-03-15 Vaporizable Tobacco Wax Compositions and Container Thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US15/923,587 2018-03-16
US15/923,587 US20180199618A1 (en) 2016-09-27 2018-03-16 Vaporizable Tobacco Wax Compositions and Container thereof
US16/159,015 US10918127B2 (en) 2016-09-27 2018-10-12 Vaporizable tobacco wax compositions and container thereof
US16/159,015 2018-10-12

Publications (1)

Publication Number Publication Date
WO2019178448A1 true WO2019178448A1 (fr) 2019-09-19

Family

ID=67906922

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2019/022417 WO2019178448A1 (fr) 2018-03-16 2019-03-15 Compositions de cire de tabac vaporisables et récipient associé

Country Status (3)

Country Link
EP (1) EP3764823A4 (fr)
CN (1) CN112566519A (fr)
WO (1) WO2019178448A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111150115A (zh) * 2020-01-17 2020-05-15 同济大学 余热利用型加热不燃烧卷烟装置

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113243551B (zh) * 2021-06-15 2022-07-22 河南中烟工业有限责任公司 一种高透气性固体烟弹及制备方法
CN113749276B (zh) * 2021-09-11 2023-04-25 深圳市真味生物科技有限公司 一种能够清新口腔且具有良好烟雾量的电子雾化液
CN113907397B (zh) * 2021-09-28 2023-09-12 深圳市真味生物科技有限公司 一种加热不燃烧发烟单元及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6066201A (en) * 1998-11-09 2000-05-23 Ergon, Inc. Thixotropic wax emulsion compositions
US20120298126A1 (en) * 2011-03-08 2012-11-29 Lorillard Tobacco Company Phase Transition Compositions Used to Impart Reduced Ignition Propensity to Smoking Articles
US20160309775A1 (en) * 2015-04-22 2016-10-27 Chase Franklin Parker Naturally extracted tobacco e-liquids and systems and methods for producing the same
WO2017077112A1 (fr) * 2015-11-05 2017-05-11 Philip Morris Products S.A. Matériau de tabac homogénéisé avec lipide fusible
EP3170413A1 (fr) * 2015-11-19 2017-05-24 Fontem Holdings 1 B.V. Dispositif à fumer électronique à éléments de chauffage fonctionnant de manière non simultanée
WO2018064032A1 (fr) * 2016-09-27 2018-04-05 Bond Street Manufacturing Llc Compositions de cire de tabac vaporisables et récipient associé

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4858630A (en) * 1986-12-08 1989-08-22 R. J. Reynolds Tobacco Company Smoking article with improved aerosol forming substrate
US7726320B2 (en) * 2006-10-18 2010-06-01 R. J. Reynolds Tobacco Company Tobacco-containing smoking article
CN100593982C (zh) * 2007-09-07 2010-03-17 中国科学院理化技术研究所 具有纳米尺度超精细空间加热雾化功能的电子烟
AU2014369110B2 (en) * 2013-12-20 2018-05-10 Philip Morris Products, S.A. Wax encapsulated flavour delivery system for tobacco
WO2015101651A1 (fr) * 2014-01-02 2015-07-09 Philip Morris Products S.A. Système de génération d'aérosol comprenant une capsule polymère cylindrique
DE202014001718U1 (de) * 2014-02-27 2015-05-28 Xeo Holding GmbH Rauchvorrichtung
RU2685029C2 (ru) * 2014-07-11 2019-04-16 Филип Моррис Продактс С.А. Картридж, образующий аэрозоль, который содержит содержащий табак материал
WO2016171997A2 (fr) * 2015-04-21 2016-10-27 Viriyapanthu Paul Composition de tabac sans fumée, procédé et appareil de vaporisation
CN106418660B (zh) * 2015-08-13 2020-03-24 上海烟草集团有限责任公司 一种电子烟烟液的制备方法及其应用
CN106065370A (zh) * 2016-07-01 2016-11-02 云南中烟工业有限责任公司 一种去除烟草乙醇提取液中蜡质的方法及所得烟用香料
MX2019000957A (es) * 2016-07-29 2019-08-01 Philip Morris Products Sa Sistema generador de aerosol que comprende un cartucho que contiene un gel.

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6066201A (en) * 1998-11-09 2000-05-23 Ergon, Inc. Thixotropic wax emulsion compositions
US20120298126A1 (en) * 2011-03-08 2012-11-29 Lorillard Tobacco Company Phase Transition Compositions Used to Impart Reduced Ignition Propensity to Smoking Articles
US20160309775A1 (en) * 2015-04-22 2016-10-27 Chase Franklin Parker Naturally extracted tobacco e-liquids and systems and methods for producing the same
WO2017077112A1 (fr) * 2015-11-05 2017-05-11 Philip Morris Products S.A. Matériau de tabac homogénéisé avec lipide fusible
EP3170413A1 (fr) * 2015-11-19 2017-05-24 Fontem Holdings 1 B.V. Dispositif à fumer électronique à éléments de chauffage fonctionnant de manière non simultanée
WO2018064032A1 (fr) * 2016-09-27 2018-04-05 Bond Street Manufacturing Llc Compositions de cire de tabac vaporisables et récipient associé

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP3764823A4 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111150115A (zh) * 2020-01-17 2020-05-15 同济大学 余热利用型加热不燃烧卷烟装置
CN111150115B (zh) * 2020-01-17 2021-11-16 同济大学 余热利用型加热不燃烧卷烟装置

Also Published As

Publication number Publication date
EP3764823A1 (fr) 2021-01-20
EP3764823A4 (fr) 2022-07-20
CN112566519A (zh) 2021-03-26

Similar Documents

Publication Publication Date Title
US10918127B2 (en) Vaporizable tobacco wax compositions and container thereof
US20180199618A1 (en) Vaporizable Tobacco Wax Compositions and Container thereof
US20180084823A1 (en) Vaporizable Tobacco Wax Compositions and Container thereof
WO2019178448A1 (fr) Compositions de cire de tabac vaporisables et récipient associé
JP7021371B2 (ja) たばこ製品組成物および送達システム
TW201733465A (zh) 菸草摻合物
JP7506681B2 (ja) 非燃焼加熱式たばこ用のたばこ充填物、非燃焼加熱式たばこ及び電気加熱式たばこ製品
WO2020100927A1 (fr) Article à fumer chauffé sans combustion et système à fumer chauffé sans combustion
CN104125782A (zh) 用于模拟吸烟的化学感受的装置和方法
KR102660689B1 (ko) 담배 함유 세그먼트 및 그 제조 방법, 비연소 가열 흡연 물품, 그리고 비연소 가열 흡연 시스템
NL7907192A (nl) Niet voor verbranding bestemde sigaret.
JP7123240B2 (ja) 非燃焼型加熱喫煙物品及びその使用方法、並びに非燃焼型加熱喫煙システム
KR102658121B1 (ko) 분리 가능한 벤투리 요소를 갖는 에어로졸 발생 장치
KR20210057772A (ko) 벤츄리 요소를 포함하는 에어로졸 발생 시스템
JP7258910B2 (ja) 非燃焼加熱喫煙物品および非燃焼加熱喫煙システム
JP2023041888A (ja) フィルターセグメント、非燃焼加熱喫煙物品及び非燃焼加熱喫煙システム
EP3737248B1 (fr) Ensemble embout buccal pour un dispositif d'inhalation comprenant un élément de substrat remplaçable, et élément de substrat remplaçable s'y rapportant
WO2019148946A1 (fr) Bâton d'herbes aromatiques pour assurer la vaporisation dans des conditions de chauffage contenant des feuilles de menthe et vg en tant qu'ingrédients principaux
JP7280435B2 (ja) 非燃焼加熱式たばこ及び電気加熱式たばこ製品
JP7197604B2 (ja) 冷却セグメント及びその製造方法、非燃焼加熱喫煙物品、並びに非燃焼加熱喫煙システム
CN103892442B (zh) 一种不燃烧卷烟及其使用方法
US20210204588A1 (en) Vaporizable Tobacco Wax Compositions and Container thereof
BR112021026174B1 (pt) Dispositivo de aerossolização de tabaco aquecido-não-queimado
JP2023530843A (ja) 送達システム及び送達システムに含まれる組成物
CN116507225A (zh) 气溶胶生成

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19767298

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2019767298

Country of ref document: EP