WO2019134418A1 - 动梁式全自动层析柱 - Google Patents

动梁式全自动层析柱 Download PDF

Info

Publication number
WO2019134418A1
WO2019134418A1 PCT/CN2018/111421 CN2018111421W WO2019134418A1 WO 2019134418 A1 WO2019134418 A1 WO 2019134418A1 CN 2018111421 W CN2018111421 W CN 2018111421W WO 2019134418 A1 WO2019134418 A1 WO 2019134418A1
Authority
WO
WIPO (PCT)
Prior art keywords
tube
column
nozzle
chromatography
port
Prior art date
Application number
PCT/CN2018/111421
Other languages
English (en)
French (fr)
Inventor
肖立峰
曲俊法
Original Assignee
湖南科众源创科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 湖南科众源创科技有限公司 filed Critical 湖南科众源创科技有限公司
Publication of WO2019134418A1 publication Critical patent/WO2019134418A1/zh

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/22—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the construction of the column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution

Definitions

  • the invention relates to a chromatography device, in particular to a moving beam type automatic chromatography column which is small in volume, easy to clean, high in column efficiency and stable in processing performance.
  • Chromatography is a gel separation method, typically such as silica gel chromatography. It separates the separated fluid from the gel in the column by molecular sieve, ion exchange or the like.
  • the chromatography column is the main body in the gel chromatography technique, generally using a glass tube or a plexiglass tube, which is filled with a gel, and has a fluid distribution plate and a sieve plate at both ends.
  • the conventional chromatography column is driven up and down by a screw drive with a central screw, so it requires a large longitudinal space for the screw to move, and because the screw is connected to the disk-shaped body with the nut and passes through several external parts thereof.
  • the connecting post is connected to the stud so that the force of the screw on the disc acts on the center of the disc, causing the disc to be easily deformed when subjected to the action of the screw.
  • the first step is to remove the cylinder between the upper and lower screens before the screen can be cleaned, and the process of removing the cylinder is complicated, and the removed cylinder will occupy the horizontal direction.
  • the space allows the entire column equipment to require large longitudinal and lateral spaces for setup and operation.
  • the invention aims to solve the above problems, and provides a dynamic beam type automatic chromatography column with small volume and small occupied space, fully automatic control, high cleaning efficiency, good cleaning effect, and convenient installation and use.
  • the present invention provides a moving beam type automatic chromatography column, which is provided with a door type bracket, and a detachable column tube is arranged in the door type bracket, and the column tube is provided with a column head which can move up and down, the column tube
  • the lower part is provided with a screen assembly
  • the column head is provided with an upper pneumatic nozzle for filling
  • the lower part of the screen assembly is provided with a lower pneumatic nozzle for discharging the filler
  • the upper part and the side of the upper pneumatic nozzle are respectively provided with an upper filler inlet , the chromatography port and the cleaning port
  • the upper beam of the door bracket can be moved up and down
  • the door bracket is connected with a driving mechanism
  • the driving mechanism is connected with the upper beam
  • the upper beam is connected with the column head Connected, the column head can be moved up and down by the beam, and the column tube can be moved upward by the upper beam during cleaning.
  • the moving beam type automatic chromatography column is provided with a control device
  • the door bracket includes an upper beam, a base, two columns and two screws, wherein the two columns are symmetrically disposed at two ends of the base, and the two screws are screwed to the upper ends of the two columns, two The screw is connected to the driving mechanism, and the upper beam is rotatably connected to the two screws through a bearing, and the two columns, the two screws and the upper beam form a door bracket.
  • the stud head comprises an upper screen, an upper liquid distribution disc, a distribution disc reinforcing ring, a diagonal pull rod and a distribution disc reinforcing plate, wherein the upper screen is fixed to the lower part of the upper liquid distribution tray, and the distribution disc reinforcing ring and the distribution disc reinforcing plate are fixed to Upper portion of the upper liquid distribution plate, the distribution plate reinforcement ring is connected to the upper beam by a plurality of diagonal tie rods.
  • the column tube is in the form of a cage, and includes an upper connecting ring, a lower connecting ring, a plurality of railings, and a chromatography tube, wherein the plurality of railings are vertically spaced between the upper connecting ring and the lower connecting ring,
  • the lower connecting ring is fixed to the base with a screw, and the chromatography tube is placed between the upper connecting ring and the lower connecting ring.
  • the upper beam is a hollow tubular body, and the driving mechanism connecting holes are arranged at both ends thereof, and a hook is connected to each of the two ends of the upper beam.
  • the screen assembly includes a lower screen and a lower liquid distribution tray, wherein the lower liquid distribution tray is fixed to an upper portion of the base, and the lower screen is fixed to an upper portion of the lower liquid distribution tray when the lower screen is cleaned Moving the upper beam downward to the upper connecting ring that hooks the hook to the column tube, and disassembling the lower connecting ring to move the upper beam upward, and the upper beam drives the column tube to move up synchronously The lower screen is exposed for cleaning.
  • the upper pneumatic nozzle comprises a nozzle body, a central tube, a filler inlet, a chromatography port and a cleaning port, and a solenoid valve is arranged at the inlet, the chromatography port and the cleaning port, and a piston is arranged on the outer side of the center tube, and the central portion of the center tube is outside
  • the sleeve is provided with a spring
  • the outer side of the lower part of the central tube is provided with an outwardly protruding ring step
  • the ring step is provided with a sealing ring
  • the lower end side wall of the central tube is provided with a plurality of upper packing outlets
  • the lower end portion of the central tube is composed of
  • the spherical end cap is sealed, and the upper part of the main body of the nozzle is provided with a gas chamber, and the air chamber is connected with an external air source, wherein the piston is provided in the air chamber, and a spring receiving cavity is arranged in the middle of the nozzle body, and the
  • the gas pushes the piston to move the center tube upward, so that the spherical nozzle is separated from the spherical end cap, and at this time, the filler inlet is opened to allow the filler to enter and exit, and when the gas chamber is not ventilated, the central tube is Under the action of said spring down, so that the spherical ball nozzle and cap are bonded together, to close the filler inlet.
  • the upper pneumatic nozzle is disposed on the distribution plate reinforcing plate, and the filler inlet, the chromatography port and the cleaning port of the upper pneumatic nozzle are located above the upper pneumatic nozzle, and the lower pneumatic nozzle is disposed at the bottom of the base, which comprises the nozzle body, the center tube and the filler
  • the outlet, the chromatography port and the cleaning port have the same structure as the upper pneumatic nozzle.
  • the driving mechanism comprises a motor, a reducer, two screws and two nuts, wherein the lower ends of the two screws are respectively screwed to the upper ends of the two columns, and the lower ends of the two screws are respectively screwed with nuts mounted on the upper ends of the two columns
  • the upper ends of the two screws are respectively connected to the output ends of the speed reducer, and the motor shaft of the motor is connected to the input end of the speed reducer.
  • the control device is a programmable controller, which is respectively electrically connected to the motor and the upper pneumatic nozzle, the filler inlet of the lower pneumatic nozzle, the chromatography port and the electromagnetic valve at the cleaning port.
  • the contribution of the present invention is that it effectively solves the problems of existing chromatography columns.
  • the invention is provided with a movable beam which can transmit the force to both ends of the beam, thereby effectively improving the stress state of the device.
  • the invention does not need to remove the column tube during the screen cleaning, the column tube can be moved up by the upward movement of the beam to perform cleaning, thereby not only greatly improving the cleaning efficiency, but also the cleaning effect is good, and the column tube is saved. Due to the lateral space occupied by the removal.
  • the driving mechanism drives the column tube to move through the beam
  • the disadvantages of the conventional column are that the screw is located on the disk-shaped body with the nut and the larger longitudinal space is used, which not only reduces the volume of the device, but also facilitates Installation and use.
  • the upper pneumatic nozzle and the lower pneumatic nozzle are provided in the present invention, the efficiency of loading and unloading the filler is greatly improved.
  • Figure 1 is a perspective view showing the overall structure of the present invention.
  • Figure 2 is a bottom perspective view of the present invention.
  • Figure 3 is a cross-sectional view showing the entire structure of the present invention.
  • FIG. 4 is a schematic structural view of the upper pneumatic nozzle of the present invention, wherein FIG. 4A is a perspective view of the outer shape, FIG. 4B is a cross-sectional view of the closed state of the spherical nozzle, and FIG. 4C is a cross-sectional view of the open state of the spherical nozzle.
  • FIG. 5 is a schematic structural view of the lower pneumatic nozzle of the present invention, wherein FIG. 5A is a perspective view of the outer shape, FIG. 5B is a cross-sectional view of the closed state of the spherical nozzle, and FIG. 5C is a cross-sectional view of the open state of the spherical nozzle.
  • the moving beam type automatic chromatography column of the present invention comprises a door bracket 10, a column tube 20, a column head 30, a screen assembly 40, an upper pneumatic nozzle 51, a lower pneumatic nozzle 52, a driving mechanism 60 and a control device. 70.
  • the gantry bracket 10 includes an upper beam 11, a base 12, two uprights 13, and two screws 14.
  • the two uprights 13 are tubular bodies having a circular cross section, and the lower ends of the two uprights 13 are symmetrically fixed to both ends of the base 12 by nuts.
  • Two screws 14 are screwed to the upper ends of the two columns 13 , and a nut 63 is fixed to the upper ends of the two columns 13 .
  • the two screws 14 are screwed to the nut 63 , and the upper ends of the two screws 14 and the driving mechanism are respectively
  • the speed reducer 62 is rotatably connected.
  • the two uprights 13, the two screws 14, the upper beam 11, and the base 12 form a gate-shaped bracket.
  • FIG. 1 the two uprights 13, the two screws 14, the upper beam 11, and the base 12 form a gate-shaped bracket.
  • the upper beam 11 is a hollow tubular body, and a first connecting hole 111 and a second connecting hole 112 are respectively disposed at two ends thereof, wherein the two first connecting holes 111 are located on the upper beam.
  • 11 is a vertical through hole at both ends, and a middle portion is provided with a step 1111 formed by a diameter reduction, and the first connecting hole 111 is for connecting the speed reducer 62 of the drive mechanism and the screw 14.
  • the two second connecting holes 112 are vertical through holes located inside the first connecting holes 111, and the lower portion of the second connecting holes 112 is provided with a ring step 1121, and the two second connecting holes are respectively at the ring step 1121
  • a hook 15 is provided, the lower end of the hook 15 is downwardly protruded from the second connecting hole 112, and when the lower screen 41 is cleaned, the upper beam 11 is moved downward to hook the column tube After the upper connecting ring 21 is attached, the column tube 20 is lifted to expose the lower screen 41 for cleaning.
  • the hook 15 is a columnar body, and the upper end portion is provided with an upper column cap 151.
  • the upper column cap 151 is movably supported on the ring step 1121, and the lower end portion of the hook 15 is provided with a lower column cap 152, and the lower column cap 152 is used.
  • the lower column cap 152 of the hook is manually hooked to the upper connecting ring 21 of the column tube.
  • the lower screen 41 can be cleaned by the upper beam 11 driving the column tube 20 upward to expose the lower screen 41.
  • a detachable column tube 20 is disposed in the gantry bracket 10 , and the column tube 20 is in a cage shape, and includes an upper connecting ring 21 , a lower connecting ring 22 , and a plurality of railings 23 . And a chromatography tube 24.
  • the plurality of rails 23 are vertically spaced between the upper connecting ring 21 and the lower connecting ring 22 and are fixed to the upper connecting ring 21 and the lower connecting ring 22.
  • the lower connecting ring 22 is fixed to the base 12 by a plurality of screws.
  • the chromatography tube 24 may be a well-known plexiglass chromatography tube 24 disposed between the upper attachment ring 21 and the lower attachment ring 22 of the column tube 20.
  • a column head 30 capable of moving up and down is disposed in the column tube 20, and the column head 30 includes an upper screen 31, an upper liquid distribution plate 32, a distribution plate reinforcing ring 33, and a diagonal rod 34.
  • the disc reinforcing plate 35 is distributed.
  • the upper screen 31 may be a well known column screen that is fixed to the lower portion of the upper liquid distribution tray 32.
  • the upper liquid distribution tray 32 may be a known liquid distribution tray for flowing fluid within the gel. Uniform, thereby improving chromatographic efficiency.
  • the upper liquid distribution tray is selected from the column fluid distributor disclosed in the application number 201410687242.0, entitled "Pressure Coupled Column Fluid Dispenser".
  • the upper portion of the upper liquid distribution tray 32 is fixed to the distribution plate reinforcing ring 33 and the distribution plate reinforcing plate 35 by screws.
  • the distribution plate reinforcement ring 33 is connected to the upper beam 11 by a plurality of diagonally-drawn rods 34.
  • the distribution plate reinforcement ring 33 is connected to the upper beam 11 by four symmetrically disposed diagonal members 34.
  • the stud head 30 is allowed to move up and down under the driving of the upper cross member 11.
  • a screen assembly 40 is disposed at a lower portion of the column tube 20, and the screen assembly 40 includes a lower screen 41 and a lower liquid distribution tray 42.
  • the lower liquid distribution tray 42 is fixed to the upper portion of the base 12 and has the same structure as the liquid distribution tray 32.
  • the lower screen 41 is fixed to the upper portion of the lower liquid distribution tray 42 and has the same structure as the upper screen 31.
  • the upper cross member 11 is driven to move downward by the driving mechanism 60 to hook the hook 15 to the upper connecting ring 21 of the column tube, and the lower connecting ring 22 is disassembled.
  • the upper beam 11 is moved upward, and the column tube 20 is moved up by the upper beam 11 to expose the lower screen 41 for cleaning.
  • an upper pneumatic head 51 for filling is provided on the column head 30, and a lower pneumatic head 52 for discharging the packing is provided at a lower portion of the screen assembly 40.
  • the structure of the upper pneumatic nozzle 51 and the lower pneumatic nozzle 52 is as shown in Figs. 4 and 5 .
  • the upper pneumatic nozzle 51 is disposed on the distribution plate reinforcing plate 35, and the filler inlet 513, the chromatography port 514 and the cleaning port 515 of the upper pneumatic nozzle are located above the distribution plate reinforcing plate 35.
  • the upper pneumatic spray head 51 includes a spray head main body 511 , a center tube 512 , a filler inlet 513 , a chromatography port 514 , and a cleaning port 515 .
  • the head body 511 is a hollow cylindrical body having an upper portion having a cylindrical shape and a lower portion having a conical shape.
  • a gas chamber 511A is disposed in an upper portion of the head body 511.
  • the air chamber 511A is connected to an air inlet 511A2 at the top of the upper pneumatic head 51 through an intake passage 511A1, and the air inlet 511A2 is in communication with an external air source.
  • a piston 516 is disposed in the air chamber 511A, and the piston 516 is fixed to a piston connecting member 519 located at an upper portion thereof.
  • a central tube 512 is disposed in the center of the nozzle body 511. The upper end of the central tube 512 extends beyond the head body 511. The lower end of the center tube 512 extends downward to the bottom of the head body 511, and the lower end side wall of the center tube 512 is disposed.
  • a spring receiving cavity 511B is disposed in the middle of the nozzle body 511, and a spring 517 is disposed on the center tube in the spring receiving cavity 511B for resetting the center tube 512.
  • An outwardly protruding ring step 5122 is disposed on the outer side of the lower portion of the central tube 512.
  • the nozzle body 511 is provided with a connecting cavity 511C outside the ring step.
  • the connecting cavity 511C is used for connecting the central tube 512 and the cleaning port 515.
  • the 511C communicates with the center tube 512 and the cleaning port 515 when not ventilated.
  • a sealing ring 5123 is mounted on the ring step 5122 for sealing the connecting chamber 511C.
  • a porous spherical nozzle 518 is connected to the lower end of the nozzle body 511.
  • the porous spherical nozzle 518 has a hemispherical shape, and is filled with a small hole for gas outlet for matching with the spherical end cap 5124 of the center tube to control the spherical shape.
  • the nozzle 518 is opened or closed.
  • the upper portion and the side surface of the upper pneumatic spray head 51 are respectively provided with a filler inlet 513 for adding a gel for use as a filler, a chromatography port 514 for adding a chromatographic liquid, and a cleaning port 515 for cleaning, at the inlet 513 of the filler.
  • a solenoid valve (not shown) is disposed at each of the chromatography port 514 and the cleaning port 515.
  • the solenoid valve is disposed in the control device 70 and electrically connected to the control device 70.
  • the control device 70 controls each electromagnetic device. The valve is opened or closed.
  • a lower pneumatic nozzle 52 for discharging the filler is provided at the lower portion of the screen assembly 40, and the structure of the lower pneumatic nozzle 52 is as shown in Figs. 5A to 5C.
  • the lower pneumatic nozzle 52 is disposed at the bottom of the base 12, and includes a nozzle body 521, a central tube 522, a filler outlet 523, a chromatography port 524, and a cleaning port 525.
  • the upper pneumatic spray head 51 is the same except that the direction of installation is opposite to that of the upper pneumatic spray head 51, and the structure of the lower pneumatic spray head 52 will not be described again.
  • a drive mechanism 60 is coupled to the gantry bracket 10, and the drive mechanism 60 is coupled to the upper cross member 11.
  • the drive mechanism 60 includes a motor 61, a speed reducer 62, two screws 14 and two nuts 63.
  • the motor 61 and the speed reducer 62 can be selected from suitable known devices.
  • the lower portions of the two screws 14 are movably inserted into the column 13 respectively, and are respectively screwed to the nuts 63 fixed to the upper ends of the two columns 13, and a screw limit is fixed at each of the lower ends of the two screws 14.
  • the disc 67 has a diameter larger than the diameter of the screw 14.
  • a nut connecting member 64 and a nut cover 65 are fixedly coupled to the upper end of the column 13, the nut 63 is a tubular body, the lower end of which is disposed in the nut cover 65, and the lower portion of the nut 63 is provided with a screw limiting member 66.
  • the diameter of the limiting member 66 is smaller than the diameter of the screw limiting plate 67, so that when the screen 41 is cleaned and washed, when the screw limiting plate 67 is ascended into position with the screw 14 and is in contact with the screw limiting member 66, the screw is restrained. Block 66 stops and stops running.
  • the upper end portions of the two screws 14 are connected to the screw receiving shaft 68 by a key, and the screw receiving shaft 68 is fixed to the output shaft 621 of the speed reducer 62, and the input end of the speed reducer 62 is connected to the motor 61. .
  • the moving beam type automatic chromatography column is provided with a control device 70.
  • the control device 70 is a programmable controller, which is respectively connected with the motor 61 and the filler inlet 513 and the chromatography port 514 of the upper pneumatic nozzle 51 and the lower pneumatic nozzle 52.
  • the solenoid valve at the cleaning port 515 is electrically connected for electrically controlling the driving mechanism 60, and pneumatically controls the upper pneumatic nozzle 51 and the lower pneumatic nozzle 52.
  • the working process of the present invention is shown in FIG. 1 , FIG. 3 , FIG. 4A to FIG. 4C , and FIG. 5A to FIG. 5C .
  • the chromatographic method and the flow can refer to the well-known methods and processes.
  • the gist of the present invention is that an upper cross member 11 that can be moved up and down is provided, so that when the lower screen 41 is cleaned, it is not necessary to rotate the column tube 20 to the outside, but only by moving the upper beam 11 upward.
  • the driving mechanism 60 is activated by the control device 70, and the upper beam 11 is driven to move downward to the upper connecting ring 21 for hooking the hook 15 to the column tube.
  • the upper beam 11 is moved upward, and the column tube 20 is moved up by the upper beam 11 to expose the lower screen 41 for cleaning.
  • the solenoid valve at the filler inlet 513 is opened by the control device 70, and the gas enters the gas chamber 511A from the intake passage 511A1 communicating with the external air source, and the gas chamber 511A During the internal intake, the gas pushes the piston 516 to move the central tube 512 upward, so that the spherical nozzle 518 is disengaged from the spherical end cap 5124, and at this time, the filler inlet 513 is opened, and the filler can be added.
  • the center tube 512 is moved downward by the spring 517, so that the spherical nozzle 518 is fitted to the spherical end cap 5124, and the filler inlet 513 is closed.
  • the solenoid valve at the chromatography port 514 is opened by the control device 70, and the fluid is injected into the chromatography tube 24.
  • the solenoid valve at the cleaning port 515 is opened by the control device 70, and the cleaning liquid is injected into the column for cleaning.
  • the present invention provides a movable beam type automatic chromatography column having a movable upper beam through which the column beam and the column head can be moved up and down, thereby making the cleaning of the lower screen mesh extremely convenient, thereby reducing
  • the size of the device saves installation and operation space and greatly improves chromatographic efficiency.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

一种动梁式全自动层析柱，设有门式支架(10)，在门式支架(10)内设有可拆式柱管(20)，柱管(20)内设有可上下移动的柱头(30)，柱管(20)下部设有筛网组件(40)，柱头(30)上设有加填料用的上气动喷头(51)，筛网组件(40)下部设有排出填料用的下气动喷头(52)，上气动喷头(51)上部及侧面分别设有填料进口(513)、层析口(514)及清洗口(515)，门式支架(10)的上横梁(11)可上下移动，门式支架(10)上连接有驱动机构(60)，驱动机构(60)与上横梁(11)相连接，上横梁(11)则与柱头(30)相连接，柱头(30)可在上横梁(11)带动下上下移动，柱管(20)在清洗时可由上横梁(11)带动向上移动；驱动机构(60)及上气动喷头(51)分别与控制装置（70）电、气连接。

Description

动梁式全自动层析柱 【技术领域】
本发明涉及层析设备，特别是涉及一种体积小，便于清洗，柱效高，处理性能稳定的动梁式全自动层析柱。
【背景技术】
层析是一种凝胶分离方法，典型的如硅胶层析法。它是使分离流体与层析柱内的凝胶进行分子筛、离子交换等反应而得到分离。层析柱是凝胶层析技术中的主体，一般用玻璃管或有机玻璃管，其内装有凝胶，两端设有流体分配盘和筛板。传统的层析柱是由设有中央的螺杆驱动柱头上下移动，因此其需要较大的纵向空间供螺杆运动，且由于其螺杆与装有螺母的盘状体相连，并通过其外部的几根连接柱与柱头相连，使得螺杆对盘状体的作用力作用于盘状体中央，导致盘状体在受到螺杆作用时容易变形。当需要对筛网进行清洗时，其首先要将位于上下筛网之间的柱筒移出，才可对筛网进行清洗，而移出柱筒的过程复杂，且移出的柱筒又会占用横向的空间，使得整个层析柱设备需要较大的纵向和横向空间用于设置和操作。
【发明内容】
本发明旨在解决上述问题，而提供一种体积及占用空间小，全自动控制，清洗效率高，清洗效果好，且便于安装使用的动梁式全自动层析柱。
为实现上述目的，本发明提供一种动梁式全自动层析柱，其设有 门式支架，在门式支架内设有可拆式柱管，该柱管内设有可上下移动的柱头，柱管下部设有筛网组件，所述柱头上设有加填料用的上气动喷头，所述筛网组件下部设有排出填料用的下气动喷头，该上气动喷头上部及侧面分别设有上填料进口、层析口及清洗口，所述门式支架的上横梁可上下移动，该门式支架上连接有驱动机构，该驱动机构与所述上横梁相连接，所述上横梁则与所述柱头相连接，所述柱头可在所述横梁带动下上下移动，所述柱管在清洗时可由所述上横梁带动向上移动，该动梁式全自动层析柱设有控制装置，所述驱动机构及上气动喷头分别与所述控制装置电、气连接。
门式支架包括上横梁、底座、两根立柱及两根螺杆，其中，所述两根立柱对称设置于所述底座两端，所述两根螺杆螺纹连接于所述两根立柱上端，两根螺杆与所述驱动机构相连接，所述上横梁通过轴承与所述两根螺杆转动连接，所述两根立柱、两根螺杆及上横梁形成门式支架。
柱头包括上筛网、上液体分配盘、分配盘加强环、斜拉杆及分配盘加强板，其中，所述上筛网固定于上液体分配盘下部，分配盘加强环及分配盘加强板固定于上液体分配盘上部，所述分配盘加强环通过多根斜拉杆与所述上横梁相连接。
柱管呈笼状，其包括上连接环、下连接环、多根栏杆及层析管，其中所述多根栏杆呈竖向间隔设置在所述上连接环和下连接环之间，所述下连接环用螺钉与所述底座固定，所述层析管置于所述上连接环与下连接环之间。
所述上横梁为中空管状体，其两端设有驱动机构连接孔，在上横梁两端底部各连接有一个挂钩。
筛网组件包括下筛网及下液体分配盘，其中，所述下液体分配盘固定于所述底座上部，所述下筛网固定于所述下液体分配盘上部，当清洗所述下筛网时，将所述上横梁向下移动到使所述挂钩勾住所述柱管的上连接环，拆开所述下连接环后将上横梁向上移动，由上横梁带动所述柱管同步上移，露出所述下筛网进行清洗。
上气动喷头包括喷头主体、中心管、填料进口、层析口及清洗口，该填料进口、层析口及清洗口处设有电磁阀，所述中心管上部外侧设有活塞，中心管中部外侧套设有弹簧，中心管下部外侧设有向外凸出的环阶，该环阶上装有密封圈，所述中心管下端部侧壁上设有多个上填料出口，中心管的下端部由球形端盖封口，所述喷头主体内上部设有气室，该气室与外部气源相连通，所述气室内设有所述活塞，喷头主体内中部设有弹簧容置腔，喷头主体内位于所述环阶外部设有连通中心管与清洗口的连接腔，该连接腔在不通气时与中心管及清洗口相连通，在所述喷头主体下端部连接有多孔球形喷嘴，当气室内进气时，气体推动所述活塞带动所述中心管上移，使得球形喷嘴与球形端盖相脱离，此时填料进口打开，可进出填料，当气室内不通气时，所述中心管在所述弹簧作用下下移，使得球形喷嘴与球形端盖相贴合，填料进口关闭。
上气动喷头设于分配盘加强板上，上气动喷头的填料进口、层析口及清洗口位于上气动喷头之上，所述下气动喷头设于底座底部，其包括喷头主体、中心管、填料出口、层析口及清洗口，其结构与所述上气动喷头相同。
驱动机构包括电机、减速器、两根螺杆及两个螺母，其中，两根螺杆的下端分别螺纹连接于两根立柱的上端，两根螺杆的下端分别与 装在两根立柱上端的螺母螺纹连接，且两根螺杆的上端部分别与减速器的输出端相连接，电机的电机轴与减速器的输入端相连接。
所述控制装置为可编程控制器，其分别与电机及上气动喷头、下气动喷头的填料进口、层析口及清洗口处的电磁阀电连接。
本发明的贡献在于，其有效解决了现有层析柱所存在的问题。本发明由于设置了可移动横梁，其可将作用力传递至横梁两端，因而有效改善了设备的受力状况。还由于本发明在进行筛网清洗时无需将柱管移出，通过横梁的向上移动即可将柱管上移而实施清洗，因而不仅可大大提高清洗效率，且清洗效果好，并节省了柱管因移出所占具的横向空间。此外，由于本发明为驱动机构经横梁带动柱管移动，而避免了传统层析柱因螺杆位于装有螺母的盘状体之上用较大纵向空间的弊端，不仅缩小了设备体积，且便于安装使用。还由于本发明设置了上气动喷头和下气动喷头，因而大大提高了装卸填料的效率。
【附图说明】
图1是本发明的整体结构立体示意图。
图2是本发明的仰视立体示意图。
图3是本发明的整体结构剖视图。
图4是本发明的上气动喷头结构示意图，其中，图4A为外形立体示意图，图4B为球形喷嘴关闭状态剖视图，图4C为球形喷嘴打开状态剖视图。
图5是本发明的下气动喷头结构示意图，其中，图5A为外形立体示意图，图5B为球形喷嘴关闭状态剖视图，图5C为球形喷嘴打开状态剖视图。
【具体实施方式】
下列实施例是对本发明的进一步解释和补充，对本发明不构成任何限制。
参阅图1～图3，本发明的动梁式全自动层析柱包括门式支架10、柱管20、柱头30、筛网组件40、上气动喷头51、下气动喷头52、驱动机构60及控制装置70。
如图1～图3所示，所述门式支架10包括上横梁11、底座12、两根立柱13及两根螺杆14。所述两根立柱13是横截面为圆形的管状体，两根立柱13的下端通过螺母对称固定于所述底座12两端。两根螺杆14螺纹连接于两根立柱13上端，在两根立柱13上端各固定有一个螺母63，所述两根螺杆14与螺母63螺纹连接，所述两根螺杆14上端与所述驱动机构的减速器62转动连接。如图1所示，所述两根立柱13、两根螺杆14、上横梁11及底座12形成门形的支架。如图3所示，所述上横梁11为中空管状体，其两端各设有一个第一连接孔111和第二连接孔112，其中，所述两个第一连接孔111是位于上横梁11两端部的竖向通孔，其中部设有直径缩小形成的台阶1111，该第一连接孔111用于连接驱动机构的减速器62与螺杆14。所述两个第二连接孔112是位于第一连接孔111内侧的竖向通孔，该第二连接孔112内下部设有环阶1121，该两个第二连接孔的环阶1121处各装有一个挂钩15，该挂钩15的下端由第二连接孔112向下伸出，其用于清洗所述下筛网41时，随所述上横梁11向下移动到勾住所述柱管的上连接环21后将所述柱管20提起，露出所述下筛网41进行清洗。所述挂钩15为柱状体，其上端部设有上柱帽 151，该上柱帽151活动支撑于所述环阶1121上，挂钩15下端部设有下柱帽152，该下柱帽152用于勾连所述的柱管20，当两个挂钩15向下移动到所述的柱管的上连接环21位置时，以手动方式将挂钩的下柱帽152勾住柱管的上连接环21，即可由上横梁11带动柱管20向上移动到露出所述下筛网41，即可对下筛网41进行清洗。
如图1、图2所示，在所述门式支架10内设有可拆式柱管20，该柱管20呈笼状，其包括上连接环21、下连接环22、多根栏杆23及层析管24。所述多根栏杆23呈竖向间隔设置在所述上连接环21和下连接环22之间并与上连接环21和下连接环22固接。所述下连接环22用多个螺钉与所述底座12固定。所述层析管24可以是公知的有机玻璃层析管24，其置于柱管20的所述上连接环21与下连接环22之间。当需要清洗下筛网41时，先要拧开固定所述下连接环22的螺钉，然后由所述驱动机构60驱动上横梁11带动柱管20向上移动升起。
如图1～图3所示，在所述柱管20内设有可上下移动的柱头30，该柱头30包括上筛网31、上液体分配盘32、分配盘加强环33、斜拉杆34及分配盘加强板35。所述上筛网31可以是公知的层析柱筛网，其固定于上液体分配盘32下部，上液体分配盘32可以是公知的液体分配盘，其用于使流体在凝胶内流动分布均匀，从而提高层析效率。优选地，本实施例中，该上液体分配盘选用申请号为201410687242.0，名称为“压力耦合式层析柱流体分配器”中公开的层析柱流体分配器。上液体分配盘32的上部用螺钉与分配盘加强环33及分配盘加强板35固定。该分配盘加强环33通过多根斜拉杆34与所述上横梁11相连接，本实施例中，该分配盘加强环33通过四根 对称设置的斜拉杆34与所述上横梁11相连接，使得该柱头30可在所述上横梁11带动下上下移动。
如图3所示，在所述柱管20下部设有筛网组件40，该筛网组件40包括下筛网41及下液体分配盘42。所述下液体分配盘42固定于所述底座12上部，其结构同上液体分配盘32。所述下筛网41固定于所述下液体分配盘42上部，其结构同上筛网31。当需要清洗所述下筛网41时，由所述驱动机构60驱动上横梁11向下移动到使所述挂钩15勾住所述柱管的上连接环21，拆开所述下连接环22后将上横梁11向上移动，由上横梁11带动所述柱管20同步上移，露出所述下筛网41进行清洗。
如图1、图3所示，在所述柱头30上设有加填料用的上气动喷头51，在所述筛网组件40下部设有排出填料用的下气动喷头52。上气动喷头51和下气动喷头52结构如图4、图5所示。
如图3所示，所述上气动喷头51设于分配盘加强板35上，上气动喷头的填料进口513、层析口514及清洗口515位于分配盘加强板35之上。
具体地，如图4A～图4C所示，该上气动喷头51包括喷头主体511、中心管512、填料进口513、层析口514及清洗口515。所述喷头主体511为内部中空的柱状体，其上部呈圆柱状，下部呈圆锥状。在喷头主体511内上部设有气室511A，该气室511A通过进气通道511A1连接至位于上气动喷头51顶部的进气口511A2，该进气口511A2则与外部气源相连通。所述气室511A内设有活塞516，该活塞516固接在位于其上部的活塞连接件519上。如图4B，在喷头主体511中央设有中心管512，该中心管512上端伸出喷头主体511 之外，中心管512下端向下延伸至喷头主体511底部，中心管512下端部侧壁上设有多个上填料出口5121，中心管512的下端部由球形端盖5124封口。在喷头主体511内中部设有弹簧容置腔511B，弹簧容置腔511B内的中心管上套设有的弹簧517，其用于中心管512的复位。在中心管512下部外侧设有向外凸出的环阶5122，喷头主体511内位于该环阶外部设有连接腔511C，该连接腔511C用于连通中心管512与清洗口515，该连接腔511C在不通气时与中心管512及清洗口515相连通。在所述环阶5122上装有密封圈5123，用于密封所述连接腔511C。在所述喷头主体511下端部连接有多孔球形喷嘴518，该多孔球形喷嘴518呈半球状，其上布满出气用的小孔，其用于与中心管的球形端盖5124配合，以控制球形喷嘴518的打开或关闭。所述上气动喷头51上部及侧面分别设有用于加入用作填料的凝胶的填料进口513，用于加入层析液体的层析口514及用于清洗的清洗口515，在该填料进口513、层析口514及清洗口515处分别设有电磁阀(图中未示出)，该电磁阀设置在所述控制装置70内，并与控制装置70电连接，该控制装置70控制各电磁阀的打开或关闭。
如图4C所示，当气室内511A进气时，气体推动所述活塞516带动所述中心管512上移，使得球形喷嘴518与球形端盖5124相脱离，此时填料进口513打开，可加入填料。如图4B所示，当气室511A内不通气时，所述中心管512在所述弹簧517作用下下移，使得球形喷嘴518与球形端盖5124相贴合，填料进口513关闭。
如图3所示，在所述筛网组件40下部设有排出填料用的下气动喷头52，下气动喷头52结构如图5A～图5C所示。
如图2及图5A～图5C所示，所述下气动喷头52设于底座12底部，其包括喷头主体521、中心管522、填料出口523、层析口524及清洗口525，其结构与所述上气动喷头51相同，只是安装的方向与上气动喷头51相反，对下气动喷头52的结构不再赘述。
如图3所示，在所述门式支架10上连接有驱动机构60，该驱动机构60与所述上横梁11相连接。所述驱动机构60包括电机61、减速器62、两根螺杆14及两个螺母63，其中，所述电机61和减速器62可选用适用的公知设备。所述两根螺杆14的下部分别活动地插入所述立柱13内，并分别与固定在两根立柱13的上端的螺母63螺纹连接，在两根螺杆14的下端部各固定有一个螺杆限位盘67，该螺杆限位盘67直径大于螺杆14的直径。在所述立柱13的上端对合固定有螺母连接件64和螺母罩65，所述螺母63为管状体，其下端置于螺母罩65内，螺母63下部装有螺杆限位件66，该螺杆限位件66直径小于所述螺杆限位盘67的直径，使得在清洗清洗下筛网41时，当螺杆限位盘67随螺杆14上行到位并与螺杆限位件66接触时被螺杆限位件66阻挡而停止运行。所述两根螺杆14的上端部与螺杆受力轴68通过键相连接，而螺杆受力轴68由与减速器62的输出轴621相固定，减速器62的输入端则与电机61相连接。
该动梁式全自动层析柱设有控制装置70，该控制装置70为可编程控制器，其分别与电机61及设于上气动喷头51、下气动喷头52的填料进口513、层析口514及清洗口515处的电磁阀电连接，用于对驱动机构60进行电动控制，并对上气动喷头51、下气动喷头52进行气动控制。
本发明的工作过程如图1、图3、图4A～图4C、图5A～图5C 所示，其层析方法和流程可参考公知的方法及流程。本发明的要点在于设置了可上下移动的上横梁11，其使得在清洗下筛网41时，无须将柱管20转出至外侧，而只需通过将上横梁11向上移动即可。具体地，当需要清洗所述下筛网41时，通过控制装置70启动所述驱动机构60，由其驱动上横梁11向下移动到使所述挂钩15勾住所述柱管的上连接环21，拆开所述下连接环22后将上横梁11向上移动，由上横梁11带动所述柱管20同步上移，露出所述下筛网41进行清洗。当要向层析管24内加注凝胶类填料时，通过控制装置70打开填料进口513处的电磁阀，气体由与外部气源连通的进气通道511A1进入气室511A内，气室511A内进气时，气体推动所述活塞516带动所述中心管512上移，使得球形喷嘴518与球形端盖5124相脱离，此时填料进口513打开，可加入填料。如图4B所示，当气室511A内不通气时，所述中心管512在所述弹簧517作用下下移，使得球形喷嘴518与球形端盖5124相贴合，填料进口513关闭。当要向层析管24内加注要分离的流体时，通过控制装置70打开层析口514处的电磁阀，将流体注入层析管24内。当要层析柱内部进行清洗时，通过控制装置70打开清洗口515处的电磁阀，将清洗液注入层析柱进行清洗。
籍此，本发明提供一种具有可移动的上横梁，通过该上横梁可带动柱管及柱头上下移动，使得下筛网的清洗变得极为方便的动梁式全自动层析柱，并由此缩小了设备体积，节省了安装及操作空间，并极大提高了层析效率。
尽管通过以上实施例对本发明进行了揭示，但本发明的保护范围并不局限于此，在不偏离本发明构思的条件下，对以上各构件所做的 变形、替换等均将落入本发明的权利要求范围内。

Claims (10)

  1. 一种动梁式全自动层析柱，其特征在于，其设有门式支架(10)，在门式支架(10)内设有可拆式柱管(20)，该柱管(20)内设有可上下移动的柱头(30)，柱管(20)下部设有筛网组件(40)，所述柱头(30)上设有加填料用的上气动喷头(51)，所述筛网组件(40)下部设有排出填料用的下气动喷头(52)，该上气动喷头(51)上部及侧面分别设有填料进口(513)、层析口(514)及清洗口(515)，所述门式支架(10)的上横梁(11)可上下移动，该门式支架(10)上连接有驱动机构(60)，该驱动机构(60)与所述上横梁(11)相连接，所述上横梁(11)则与所述柱头(30)相连接，所述柱头(30)可在所述横梁(11)带动下上下移动，所述柱管(20)在清洗时可由所述上横梁(11)带动向上移动，该动梁式全自动层析柱设有控制装置(70)，所述驱动机构(60)、上气动喷头(51)及下气动喷头(52)分别与所述控制装置(70)电、气连接。
  2. 如权利要求1所述的动梁式全自动层析柱，其特征在于，所述门式支架(10)包括上横梁(11)、底座(12)、两根立柱(13)及两根螺杆(14)，其中，所述两根立柱(13)对称设置于所述底座(12)两端，所述两根螺杆(14)螺纹连接于所述两根立柱(13)上端，两根螺杆(14)与所述驱动机构(60)相连接，所述上横梁(11)通过轴承与所述两根螺杆(14)转动连接，所述两根立柱(13)、两根螺杆(14)及上横梁(11)形成门式支架。
  3. 如权利要求1所述的动梁式全自动层析柱，其特征在于，所述柱头(30)包括上筛网(31)、上液体分配盘(32)、分配盘加强 环(33)、斜拉杆(34)及分配盘加强板(35)，其中，所述上筛网(31)固定于上液体分配盘(32)下部，分配盘加强环(33)及分配盘加强板(35)固定于上液体分配盘(32)上部，所述分配盘加强环(33)通过多根斜拉杆(34)与所述上横梁(11)相连接。
  4. 如权利要求2所述的动梁式全自动层析柱，其特征在于，所述柱管(20)呈笼状，其包括上连接环(21)、下连接环(22)、多根栏杆(23)及层析管(24)，其中所述多根栏杆(23)呈竖向间隔设置在所述上连接环(21)和下连接环(22)之间，所述下连接环(22)用螺钉与所述底座(12)固定，所述层析管(24)置于所述上连接环(21)与下连接环(22)之间。
  5. 如权利要求4所述的动梁式全自动层析柱，其特征在于，所述上横梁(11)为中空管状体，其两端设有驱动机构连接孔，在上横梁(11)两端底部各连接有一个挂钩(15)。
  6. 如权利要求5所述的动梁式全自动层析柱，其特征在于，所述筛网组件(40)包括下筛网(41)及下液体分配盘(42)，其中，所述下液体分配盘(42)固定于所述底座(12)上部，所述下筛网(41)固定于所述下液体分配盘(42)上部，当清洗所述下筛网(41)时，将所述上横梁(11)向下移动到使所述挂钩(15)勾住所述柱管的上连接环(21)，拆开所述下连接环(22)后将上横梁(11)向上移动，由上横梁(11)带动所述柱管(20)同步上移，露出所述下筛网(41)进行清洗。
  7. 如权利要求1所述的动梁式全自动层析柱，其特征在于，所述上气动喷头(51)包括喷头主体(511)、中心管(512)、填料进口(513)、层析口(514)及清洗口(515)，该填料进口(513)、层 析口(514)及清洗口(515)处设有电磁阀，所述中心管(512)上部外侧设有活塞(516)，中心管(512)中部外侧套设有弹簧(517)，中心管(512)下部外侧设有向外凸出的环阶(5122)，该环阶上装有密封圈(5123)，所述中心管(512)下端部侧壁上设有多个上填料出口(5121)，中心管(512)的下端部由球形端盖(5124)封口，所述喷头主体(511)内上部设有气室(511A)，该气室(511A)与外部气源相连通，所述气室(511A)内设有所述活塞(516)，喷头主体(511)内中部设有弹簧容置腔(511B)，喷头主体(511)内位于所述环阶外部设有连通中心管(512)与清洗口(515)的连接腔(511C)，该连接腔(511C)在不通气时与中心管(512)及清洗口(515)相连通，在所述喷头主体(511)下端部连接有多孔球形喷嘴(518)，当气室内(511A)进气时，气体推动所述活塞(516)带动所述中心管(512)上移，使得球形喷嘴(518)与球形端盖(5124)相脱离，此时填料进口(513)打开，可进出填料，当气室(511A)内不通气时，所述中心管(512)在所述弹簧(517)作用下下移，使得球形喷嘴(518)与球形端盖(5124)相贴合，填料进口(513)关闭。
  8. 如权利要求7所述的动梁式全自动层析柱，其特征在于，所述上气动喷头(51)设于分配盘加强板(35)上，上气动喷头的填料进口(513)、层析口(514)及清洗口(515)位于上气动喷头(51)之上，所述下气动喷头(52)设于底座(12)底部，其包括喷头主体(521)、中心管(522)、填料出口(523)、层析口(524)及清洗口(525)，其结构与所述上气动喷头(51)相同。
  9. 如权利要求1所述的动梁式全自动层析柱，其特征在于，所 述驱动机构(60)包括电机(61)、减速器(62)、两根螺杆(14)及两个螺母(63)，其中，两根螺杆(14)的下端分别螺纹连接于两根立柱(13)的上端，两根螺杆(14)的下端分别与装在两根立柱(13)上端的螺母(63)螺纹连接，且两根螺杆(14)的上端部分别与减速器(62)的输出端相连接，电机(61)的电机轴与减速器(62)的输入端相连接。
  10. 如权利要求9所述的动梁式全自动层析柱，其特征在于，所述控制装置(70)为可编程控制器，其分别与电机(61)及上气动喷头(51)、下气动喷头(52)的填料进口(513)、层析口(514)及清洗口(515)处的电磁阀电连接。
PCT/CN2018/111421 2018-01-08 2018-10-23 动梁式全自动层析柱 WO2019134418A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201810015645.0 2018-01-08
CN201810015645.0A CN107982961A (zh) 2018-01-08 2018-01-08 动梁式全自动层析柱

Publications (1)

Publication Number Publication Date
WO2019134418A1 true WO2019134418A1 (zh) 2019-07-11

Family

ID=62039699

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/111421 WO2019134418A1 (zh) 2018-01-08 2018-10-23 动梁式全自动层析柱

Country Status (2)

Country Link
CN (1) CN107982961A (zh)
WO (1) WO2019134418A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106731001A (zh) * 2017-01-04 2017-05-31 山东省分析测试中心 一种分体式的逆流色谱分离柱

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107982961A (zh) * 2018-01-08 2018-05-04 湖南科众源创科技有限公司 动梁式全自动层析柱
CN112121466B (zh) * 2020-05-22 2022-04-05 湖南科众源创科技有限公司 层析柱装置及层析柱装柱方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090039008A1 (en) * 2007-06-15 2009-02-12 Ge Healthcare Bio-Sciences Ab Method for conducting maintenance on a chromatography column
CN101925815A (zh) * 2008-01-23 2010-12-22 通用电气健康护理生物科学股份公司 色谱柱及维护方法
CN103505909A (zh) * 2012-06-21 2014-01-15 通用电气健康护理生物科学股份公司 层析柱框架和对层析柱进行维护和填充的方法
CN204073505U (zh) * 2013-12-17 2015-01-07 长沙市源创精科生物技术有限公司 一种全自动层析柱
CN104307206A (zh) * 2014-02-17 2015-01-28 长沙市源创精科生物技术有限公司 一种用于层析柱的静密封多通道喷头设计
CN107982961A (zh) * 2018-01-08 2018-05-04 湖南科众源创科技有限公司 动梁式全自动层析柱

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104307207B (zh) * 2013-12-17 2016-07-06 源创精科生物科技(长沙)有限公司 一种全自动层析柱
CN208049453U (zh) * 2018-01-08 2018-11-06 湖南科众源创科技有限公司 动梁式全自动层析柱

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090039008A1 (en) * 2007-06-15 2009-02-12 Ge Healthcare Bio-Sciences Ab Method for conducting maintenance on a chromatography column
CN101925815A (zh) * 2008-01-23 2010-12-22 通用电气健康护理生物科学股份公司 色谱柱及维护方法
CN103505909A (zh) * 2012-06-21 2014-01-15 通用电气健康护理生物科学股份公司 层析柱框架和对层析柱进行维护和填充的方法
CN204073505U (zh) * 2013-12-17 2015-01-07 长沙市源创精科生物技术有限公司 一种全自动层析柱
CN104307206A (zh) * 2014-02-17 2015-01-28 长沙市源创精科生物技术有限公司 一种用于层析柱的静密封多通道喷头设计
CN107982961A (zh) * 2018-01-08 2018-05-04 湖南科众源创科技有限公司 动梁式全自动层析柱

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106731001A (zh) * 2017-01-04 2017-05-31 山东省分析测试中心 一种分体式的逆流色谱分离柱

Also Published As

Publication number Publication date
CN107982961A (zh) 2018-05-04

Similar Documents

Publication Publication Date Title
WO2019134418A1 (zh) 动梁式全自动层析柱
US8562826B2 (en) Supporting structures for preparative chromatography columns
CN101068609B (zh) 色谱柱
JP2008506093A (ja) クロマトグラフィーカラムおよびその操作
CN107377560A (zh) 一种药瓶自动定位冲洗装置
CN212372413U (zh) 混凝土砂浆储存罐
CN208049453U (zh) 动梁式全自动层析柱
CN107638295A (zh) 一种流化床底喷包衣装置
CN212440149U (zh) 下驱动动梁式全自动层析柱
CN206081824U (zh) 单筒自动立式压滤机
CN206818700U (zh) 一种模拟降雨的实验装置
CN105087378A (zh) 一种磁珠分选仪
CN111804660B (zh) 一种中草药清洗设备
CN209595669U (zh) 一种陶瓷花瓶内部清洗装置
CN203861897U (zh) 小球互动游戏装置
CN209612443U (zh) 一种袋式除尘装置
CN203170026U (zh) 一种动感平台
CN111715868B (zh) 一种水龙头的落砂集砂装置
JPH01501136A (ja) 充填設備における分配装置、とりわけ液体およびペースト状の製品のための充填装置とこの分配装置を操作するための方法
CN108552469A (zh) 一种年糕制作装置
CN109292716A (zh) 一种保健酒灌装机及方法
CN221472933U (zh) 一种洗烘窄口试剂瓶的装置
CN115382692B (zh) 一种金属椅智能喷涂设备及方法
CN219481760U (zh) 一种集束式过滤器
CN221309388U (zh) 一种压力式比例混合装置

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18898277

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 18898277

Country of ref document: EP

Kind code of ref document: A1