WO2019125313A1 - Burn treatment cream and production method thereof - Google Patents

Burn treatment cream and production method thereof Download PDF

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Publication number
WO2019125313A1
WO2019125313A1 PCT/TR2017/050736 TR2017050736W WO2019125313A1 WO 2019125313 A1 WO2019125313 A1 WO 2019125313A1 TR 2017050736 W TR2017050736 W TR 2017050736W WO 2019125313 A1 WO2019125313 A1 WO 2019125313A1
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WO
WIPO (PCT)
Prior art keywords
oil
cream
production method
egg yolk
weight
Prior art date
Application number
PCT/TR2017/050736
Other languages
French (fr)
Inventor
Muharrem ÇALIŞKAN
Original Assignee
Caliskan Muharrem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Caliskan Muharrem filed Critical Caliskan Muharrem
Publication of WO2019125313A1 publication Critical patent/WO2019125313A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Definitions

  • This invention is related to a bum cream/ointment used for the treatment of chemical bums besides first, second and third-degree burns.
  • Burns are caused by various external sources which are classified as heat, chemical, electricity and radiation. Bum is a type of injury that occurs on the flesh or skin due to heat, electricity, chemicals, friction, or radiation. Burns that only affect the upper layer of the skin are defined as superficial or first-degree bums. Burns are sometimes referred to as partially thicker bums or second-degree burns when deeper layers are affected. In full thickness or third-degree burns, the burn affects all layers of the skin. In fourth-degree bums, the wound also affects deeper tissues such as muscle or bone.
  • Burns can be very painful; many different options are available for pain treatment.
  • analgesics such as ibuprofen and acetaminophen
  • opioids such as morphine.
  • Benzodiazepines may be used in addition to analgesics to reduce anxiety.
  • antihistamines, massage, or transcutaneous nerve stimulation can be used to relieve the itchiness.
  • a bum cream is mentioned within the patent document TR2008 / 02093 present in the current technique.
  • the cream is a product made of egg yolk and olive oil to treat the bums on the skin and resolve the pain and cosmetic appearance of the skin.
  • the patent document TR2012 / 10606 in the present technique refers to a burn treatment ointment.
  • the document is related to an ointment with a herbal combination to be used in burn treatments.
  • the ointment is obtained by compounding olive oil, beeswax, turpentine, boswellia, mastic gum, fir gum, blackthorn and orchanet root at certain ratios.
  • the patent document TR2014 / 07106 includes information on the burn cream which is made of wax, olive oil and powder for therapeutic purposes to be used in second and third-degree skin bums, its substance properties, effects and amounts of active ingredients included are described.
  • the objective of the invention is to create a burning cream/ointment to be used for the treatment of chemical bums, as well as first, second and third-degree burns. It is also desired that the cream will resolve the pain associated with burns rapidly.
  • the bum cream developed to achieve the above-mentioned objectives includes; olive oil, wax, egg yolk oil, fish oil, diphenhydramine and sulphanilamide.
  • the invention is a burn cream/ointment used in the treatment of first, second and third degree burns as well as chemical burns and includes olive oil, wax, egg yolk oil, fish oil (preferred whale oil), diphenhydramine and sulphanilamide.
  • the invention is characterised as; being a burn cream/ointment used in the treatment of first, second and third degree burns as well as chemical bums; including olive oil, wax, egg yolk oil, fish oil (preferred whale oil), diphenhydramine and sulphanilamide and containing ingredients of 80-90% olive oil, 1-6% egg yolk oil , 2-8% fish oil (preferred whale oil), 3-9% wax, 0,02-0,1% diphenhydramine and 0,1 -0,5% sulphanilamide.
  • the special compounding techniques include;
  • the invention is applied by spreading on bums.
  • the invention is effective for all types of bums. It is also used in sunburn and chemical burns. Within 45 minutes of application, there will be no pain and the risk of infection will be reduced. The wound won't blister. It does not leave burn marks even in third degree bums. In first-degree bums, complete healing takes up to 10 hours.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Insects & Arthropods (AREA)
  • Zoology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Husbandry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention is characterised as; being a burn cream/ointment used in the treatment of first, second and third degree burns as well as chemical burns; including olive oil, wax, egg yolk oil, fish oil (preferred whale oil), diphenhydramine and sulphanilamide and containing ingredients of 80-90% olive oil, 1-6% egg yolk oil, 2-8% fish oil (preferred whale oil), 3-9% wax, 0,02-0,1% diphenhydramine and 0,1-0,5% sulphanilamide.

Description

Burn Treatment Cream and Production Method Thereof
Field of The Invention
This invention is related to a bum cream/ointment used for the treatment of chemical bums besides first, second and third-degree burns.
Background of The Invention
Burns are caused by various external sources which are classified as heat, chemical, electricity and radiation. Bum is a type of injury that occurs on the flesh or skin due to heat, electricity, chemicals, friction, or radiation. Burns that only affect the upper layer of the skin are defined as superficial or first-degree bums. Burns are sometimes referred to as partially thicker bums or second-degree burns when deeper layers are affected. In full thickness or third-degree burns, the burn affects all layers of the skin. In fourth-degree bums, the wound also affects deeper tissues such as muscle or bone.
The treatment required depends on the severity of the burn. While superficial burns can be treated with simple pain-killers, deeper bums may require longer treatment in special bum-treatment centres. Keeping the burnt area under cold water can relieve pain and reduce the wound formation, however prolonged exposure to cold can also decrease body temperature. Partially thicker burns may need to be cleaned and bandaged. Full thickness burns usually require surgical treatments such as skin grafting. In large bums, a high amount of intravenous fluid is usually required, because the inflammatory response of the body will result in significant fluid withdrawal from the capillary and oedema formation. The most common complications of burns are related to infection. Burns can be very painful; many different options are available for pain treatment. These include the use of simple analgesics (such as ibuprofen and acetaminophen) and opioids such as morphine. Benzodiazepines may be used in addition to analgesics to reduce anxiety. During the healing process, antihistamines, massage, or transcutaneous nerve stimulation can be used to relieve the itchiness.
A bum cream is mentioned within the patent document TR2008 / 02093 present in the current technique. The cream is a product made of egg yolk and olive oil to treat the bums on the skin and resolve the pain and cosmetic appearance of the skin.
The patent document TR2012 / 10606 in the present technique however, refers to a burn treatment ointment. The document is related to an ointment with a herbal combination to be used in burn treatments. The ointment is obtained by compounding olive oil, beeswax, turpentine, boswellia, mastic gum, fir gum, blackthorn and orchanet root at certain ratios.
In the present technique, the patent document TR2014 / 07106 includes information on the burn cream which is made of wax, olive oil and powder for therapeutic purposes to be used in second and third-degree skin bums, its substance properties, effects and amounts of active ingredients included are described.
The Objective of The Invention
The objective of the invention is to create a burning cream/ointment to be used for the treatment of chemical bums, as well as first, second and third-degree burns. It is also desired that the cream will resolve the pain associated with burns rapidly. The bum cream developed to achieve the above-mentioned objectives includes; olive oil, wax, egg yolk oil, fish oil, diphenhydramine and sulphanilamide.
Detailed Description of The Invention
The invention is a burn cream/ointment used in the treatment of first, second and third degree burns as well as chemical burns and includes olive oil, wax, egg yolk oil, fish oil (preferred whale oil), diphenhydramine and sulphanilamide.
The weight percentages of the substances are stated below;
• Olive Oil 80-90%
• Egg Yolk Oil 1-6%
• Fish Oil (preferred Whale Oil) 2-8%
• Wax 3-9%
• Diphenhydramine 0,02-0,1%
• Sulphanilamide 0,1 -0,5% Extra virgin olive oil is heated to at least l70°C -l80°C. When this temperature is reached, wax is added, and the added wax is melted by mixing. The heating is then terminated and egg yolk oil, fish oil (preferred whale oil), diphenhydramine and sulphanilamide are added. After stirring for 3-5 minutes, the preparation is allowed to rest for 6-7 hours. The ready-to-use ointment is then ready to be packaged.
Any kind of poultries can be used to obtain the oil of the egg yolk. Chicken eggs are preferred because they can be supplied easily. Also, any type of fish oil can be used as fish oil, however, the use of whale oil increases the effectiveness of the product. The invention is characterised as; being a burn cream/ointment used in the treatment of first, second and third degree burns as well as chemical bums; including olive oil, wax, egg yolk oil, fish oil (preferred whale oil), diphenhydramine and sulphanilamide and containing ingredients of 80-90% olive oil, 1-6% egg yolk oil , 2-8% fish oil (preferred whale oil), 3-9% wax, 0,02-0,1% diphenhydramine and 0,1 -0,5% sulphanilamide.
Being a burn cream/ointment used in the treatment of first, second and third degree bums as well as chemical burns, the special compounding techniques include;
Heating the extra virgin olive oil of 80-90% weight to at least l70°C -l80°C.
When this temperature is reached, adding the 3-9% in weight of wax and melting it by mixing.
Terminating the heating and adding 1-6% egg yolk oil, 2-8% fish oil (preferred whale oil), 0,02-0,1% diphenhydramine and 0, 1-0,5% sulphanilamide.
Stirring for 3-5 minutes and allowing the preparation to rest for 6-7 hours.
Packaging the ready-to-use cream/ointment prepared.
The invention is applied by spreading on bums. The invention is effective for all types of bums. It is also used in sunburn and chemical burns. Within 45 minutes of application, there will be no pain and the risk of infection will be reduced. The wound won't blister. It does not leave burn marks even in third degree bums. In first-degree bums, complete healing takes up to 10 hours.

Claims

1. A burn cream/ointment used in the treatment of first, second and third degree burns as well as chemical burns characterised in that; it comprises olive oil, wax, egg yolk oil, fish oil (preferred whale oil), diphenhydramine and sulphanilamide.
2. A cream as mentioned in claim 1 wherein weight ratios of the components are characterized as; 80-90% olive oil, 1-6% egg yolk oil, 2-8% fish oil, 3- 9% wax, 0.02-0.1% diphenhydramine and 0.1-0.5% sulphanilamide.
3. A cream mentioned in claim 1 characterised in that; the fish oil listed in the formulation is whale oil.
4. A cream mentioned in claim 1 characterised in that; the egg yolk oil is obtained from poultries.
5. A method for the production of a burn cream/ointment used in the treatment of first, second and third degree burns as well as chemical bums, wherein following process steps are included;
The olive oil is heated up to at least least l70°C -l80°C.
Beeswax is added when this temperature is reached and added beeswax is melted by stirring,
- The heating operation is terminated and egg yolk oil fish oil (preferably whale oil), diphenhydramine and sulphanilamide are added,
The preparation is left for maturing for 6-7 hours after mixing for 3-5 minutes,
Packaging the ready-to-use cream/ointment prepared.
6. A production method mentioned in claim 5 characterised in that; it comprises 80-90% olive oil by weight.
7. A production method mentioned in claim 5 characterised in that; it comprises 1-6% egg yolk oil by weight.
8. A production method mentioned in claim 5 characterised in that; it
comprises 2-8% fish oil by weight.
9. It is the production method mentioned in claim 5 characterised in that; it comprises 3-9% wax by weight.
10. It is the production method mentioned in claim 5 characterised in that; it comprises 0,02-0,1% diphenhydramine by weight.
11. It is the production method mentioned in claim 5 characterised in that; it comprises 0, 1-0,5% sulphanilamide by weight.
PCT/TR2017/050736 2017-12-21 2017-12-30 Burn treatment cream and production method thereof WO2019125313A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
TR2017/20999 2017-12-21
TR201720999 2017-12-21

Publications (1)

Publication Number Publication Date
WO2019125313A1 true WO2019125313A1 (en) 2019-06-27

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020188305A1 (en) * 2019-03-18 2020-09-24 Patsianidi Helen Ointment for the treatment of burns

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB765600A (en) * 1954-01-15 1957-01-09 Drug Houses Of Australia Ltd Salves for veterinary use
US4748022A (en) * 1985-03-25 1988-05-31 Busciglio John A Topical composition
RU2010124992A (en) * 2010-06-17 2011-12-27 Закрытое акционерное общество "СНС-фарма" (RU) MEDICINE FOR TREATMENT OF RAS, BURNS AND INFECTIOUS INFLAMMATORY DISEASES OF THE SKIN, APPLICATIONS OF THE SKIN AND Mucous membranes
US20150313950A1 (en) * 2012-12-10 2015-11-05 Regenics As Use of cellular extracts for skin rejuvenation
US20160022676A1 (en) * 2014-07-22 2016-01-28 Meridian Research And Development, Inc. Topical medications for bruises and burns

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB765600A (en) * 1954-01-15 1957-01-09 Drug Houses Of Australia Ltd Salves for veterinary use
US4748022A (en) * 1985-03-25 1988-05-31 Busciglio John A Topical composition
RU2010124992A (en) * 2010-06-17 2011-12-27 Закрытое акционерное общество "СНС-фарма" (RU) MEDICINE FOR TREATMENT OF RAS, BURNS AND INFECTIOUS INFLAMMATORY DISEASES OF THE SKIN, APPLICATIONS OF THE SKIN AND Mucous membranes
US20150313950A1 (en) * 2012-12-10 2015-11-05 Regenics As Use of cellular extracts for skin rejuvenation
US20160022676A1 (en) * 2014-07-22 2016-01-28 Meridian Research And Development, Inc. Topical medications for bruises and burns

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020188305A1 (en) * 2019-03-18 2020-09-24 Patsianidi Helen Ointment for the treatment of burns

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