WO2019112161A3 - 조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물 - Google Patents
조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물 Download PDFInfo
- Publication number
- WO2019112161A3 WO2019112161A3 PCT/KR2018/011852 KR2018011852W WO2019112161A3 WO 2019112161 A3 WO2019112161 A3 WO 2019112161A3 KR 2018011852 W KR2018011852 W KR 2018011852W WO 2019112161 A3 WO2019112161 A3 WO 2019112161A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stem cells
- cells
- wrinkle improvement
- skin regeneration
- cell proliferation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/982—Reproductive organs; Embryos, Eggs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/981—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
- A61K8/985—Skin or skin outgrowth, e.g. hair, nails
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/70—Undefined extracts
- C12N2500/80—Undefined extracts from animals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/02—Coculture with; Conditioned medium produced by embryonic cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/08—Coculture with; Conditioned medium produced by cells of the nervous system
- C12N2502/088—Coculture with; Conditioned medium produced by cells of the nervous system neural stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Birds (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Developmental Biology & Embryology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Immunology (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Cosmetics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
본 발명은 조류의 에그(egg)로부터 분리한 세포인 배반엽 전분화능세포(pluripotent stem cells, PSCs) 또는 신경줄기세포(neural stem cells, NSCs),배아섬유아세포(embryonic fibroblasts, FBs) 컨디션드 배지(conditioned medium)를 유효성분으로 함유하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물에 관한 것으로, 구체적으로 에그(egg) 세포 컨디션드 배지는 동물성 혈청의 사용으로 인한 오염을 원천적으로 차단할 수 있고, 나아가 지지세포 사용으로 인한 이종 간의 감염물질에 의한 전염 가능성 없이, 인간 줄기세포, 피부세포를 포함하는 다양한 세포 증식 효과를 나타내며, 또한 유의적인 피부 재생 또는 주름 개선 효과를 나타내므로, 에그 세포 컨디션드 배지를 세포 증식용 배지 조성물, 및 피부 재생 또는 주름개선용 화장료 조성물로 유용하게 사용될 수 있다.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201880078775.7A CN111511901A (zh) | 2017-12-06 | 2018-10-10 | 包含作为从鸟类的蛋分离的细胞的胚盘多能干细胞、神经干细胞、胚胎成纤维细胞条件培养基作为有效成分的用于细胞增殖、皮肤再生及皱纹改善的培养基组合物 |
US16/769,986 US11564951B2 (en) | 2017-12-06 | 2018-10-10 | Medium composition for cell proliferation, skin regeneration, and wrinkle improvement comprising, as active ingredient, conditioned medium of pluripotent stem cells, neural stem cells, or embryonic fibroblasts which are isolated from avian eggs |
JP2020550566A JP7092886B2 (ja) | 2017-12-06 | 2018-10-10 | 鳥類の卵から分離した細胞である胚盤葉多能性幹細胞、神経幹細胞、胚性線維芽細胞条件培地を有効成分とする細胞の増殖、肌の再生、及びシワ改善用の培地組成物 |
EP18885818.7A EP3722414A4 (en) | 2017-12-06 | 2018-10-10 | MEDIUM COMPOSITION FOR CELL PROLIFERATION, SKIN REGENERATION AND WRINKLE IMPROVEMENT WITH CONDITIONED MEDIUM ISOLATED FROM BIRD EGGS, PLURIPOTENT STEM CELLS, NEURONAL STEM CELLS OR EMBRYONAL FIBROBLASTS AS THE ACTIVE SUBSTANCE |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2017-0166745 | 2017-12-06 | ||
KR1020170166745A KR102121042B1 (ko) | 2017-12-06 | 2017-12-06 | 조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2019112161A2 WO2019112161A2 (ko) | 2019-06-13 |
WO2019112161A3 true WO2019112161A3 (ko) | 2019-07-25 |
Family
ID=66751034
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2018/011852 WO2019112161A2 (ko) | 2017-12-06 | 2018-10-10 | 조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물 |
Country Status (6)
Country | Link |
---|---|
US (1) | US11564951B2 (ko) |
EP (1) | EP3722414A4 (ko) |
JP (1) | JP7092886B2 (ko) |
KR (1) | KR102121042B1 (ko) |
CN (1) | CN111511901A (ko) |
WO (1) | WO2019112161A2 (ko) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20210395678A1 (en) * | 2018-11-08 | 2021-12-23 | Integriculture Inc. | Animal cell growth promoter, culture medium for animal cell culture, and animal cell culture apparatus |
CN112755177B (zh) * | 2021-03-15 | 2022-03-18 | 浙江大学 | 一种含有鸡胚egf的口服液及制备方法和应用 |
KR20240083156A (ko) | 2022-10-27 | 2024-06-11 | 선문대학교 산학협력단 | 담수 유래의 미세조류 추출물을 유효성분으로 함유하는 피부 주름, 피부 노화, 피부 창상 예방 또는 개선 또는 치료용 조성물 |
CN116584379B (zh) * | 2023-05-04 | 2024-06-21 | 广西壮族自治区药用植物园 | 化橘红组织培养快速繁殖方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5830510A (en) * | 1992-05-15 | 1998-11-03 | North Carolina State University | Veterinary pharmaceutical formulation containing avian embryonic stem cells |
WO2012170995A2 (en) * | 2011-06-10 | 2012-12-13 | University Of Georgia Research Foundation, Inc. | Avian induced pluripotent stem cells and their use |
KR20180007256A (ko) * | 2016-07-12 | 2018-01-22 | 이정복 | 에그 세포 배양액을 유효성분으로 포함하는 인간 줄기세포 성장용 배지 조성물 |
KR20180035763A (ko) * | 2018-03-26 | 2018-04-06 | 이정복 | 에그 세포 배양액을 유효성분으로 포함하는 인간 줄기세포 성장용 배지 조성물 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6667176B1 (en) * | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
CN101044235B (zh) * | 2004-09-08 | 2013-01-02 | 威斯康星校友研究基金会 | 胚胎干细胞的培养基和培养 |
US20060174362A1 (en) * | 2005-02-01 | 2006-08-03 | Origen Therapeutics, Inc. | Long-term culture of avian primordial germ cells (PGCs) |
CA2656175C (en) * | 2006-06-26 | 2018-08-28 | Lifescan, Inc. | Conditioned media obtained from amniotic fluid-derived cells for pluripotent stem cell culture |
EP1985305A1 (en) | 2007-04-24 | 2008-10-29 | Vivalis | Duck embryonic derived stem cell lines for the production of viral vaccines |
EP2072616A1 (en) | 2007-12-17 | 2009-06-24 | Institut National De La Recherche Agronomique | Method for reprogramming in vitro stem cells and somatic cells into germinal cells |
KR20100096447A (ko) * | 2009-02-24 | 2010-09-02 | 주식회사 알앤엘바이오 | 돼지 태반 조직 유래 줄기세포의 배양물 및 그 추출 단백질을 함유한 화장료용 조성물 |
CN102329771A (zh) * | 2011-10-12 | 2012-01-25 | 佛山科学技术学院 | 长期传代培养鸡胚胎干细胞的方法及其专用培养基 |
AU2012326137B2 (en) * | 2011-10-17 | 2018-11-29 | Minerva Biotechnologies Corporation | Media for stem cell proliferation and induction |
KR20140072676A (ko) * | 2012-12-05 | 2014-06-13 | 건국대학교 산학협력단 | 형질전환 닭 역분화 만능줄기세포의 제조방법 |
CN105246494B (zh) * | 2013-04-19 | 2020-02-07 | 高丽大学校产学协力团 | 刺激毛发生长或防止毛发脱落的包括神经干细胞的提取物的组合物及其制造方法 |
KR20150009898A (ko) * | 2013-07-17 | 2015-01-27 | 김혜정 | 인간 지방유래 줄기세포 배양액 추출물을 함유한 화장품 조성물 및 이를 이용한 화장품 |
WO2015028900A1 (en) * | 2013-08-29 | 2015-03-05 | Stempeutics Research Pvt. Ltd. | Stromal cells derived conditioned medium, method of obtaining said conditioned medium compositions, formulations and applications thereof |
CN106318904B (zh) * | 2015-06-15 | 2020-08-11 | 上海朗斯生物工程有限公司 | 间充质干细胞条件培养基用于美容品领域的用途 |
CN104997708A (zh) * | 2015-07-07 | 2015-10-28 | 河南中科干细胞基因工程有限公司 | 干细胞条件培养基的获取及在防皮肤老化方面的应用 |
CN106511387A (zh) * | 2016-10-26 | 2017-03-22 | 谢培增 | 鸡胚胎素制备方法及应用 |
KR101830062B1 (ko) * | 2017-06-30 | 2018-02-20 | 주식회사 차바이오텍 | 피부줄기세포 배양액을 포함하는 피부 노화 예방 또는 개선용 조성물 및 이의 용도 |
-
2017
- 2017-12-06 KR KR1020170166745A patent/KR102121042B1/ko active IP Right Grant
-
2018
- 2018-10-10 WO PCT/KR2018/011852 patent/WO2019112161A2/ko unknown
- 2018-10-10 CN CN201880078775.7A patent/CN111511901A/zh active Pending
- 2018-10-10 EP EP18885818.7A patent/EP3722414A4/en active Pending
- 2018-10-10 JP JP2020550566A patent/JP7092886B2/ja active Active
- 2018-10-10 US US16/769,986 patent/US11564951B2/en active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5830510A (en) * | 1992-05-15 | 1998-11-03 | North Carolina State University | Veterinary pharmaceutical formulation containing avian embryonic stem cells |
WO2012170995A2 (en) * | 2011-06-10 | 2012-12-13 | University Of Georgia Research Foundation, Inc. | Avian induced pluripotent stem cells and their use |
KR20180007256A (ko) * | 2016-07-12 | 2018-01-22 | 이정복 | 에그 세포 배양액을 유효성분으로 포함하는 인간 줄기세포 성장용 배지 조성물 |
KR20180035763A (ko) * | 2018-03-26 | 2018-04-06 | 이정복 | 에그 세포 배양액을 유효성분으로 포함하는 인간 줄기세포 성장용 배지 조성물 |
Non-Patent Citations (3)
Title |
---|
MACDONALD, JONI: "Characterisation and Germline Transmission of Cultured Avian Primordial Germ Cells", PLOS ONE, 2010, pages e15518, XP055167559, DOI: 10.1371/journal.pone.0015518 * |
NAKANOH, SHOTA -§: "Inhibition of MEK and GSK3 supports ES cell -like domed colony formation from avian and reptile embryos", ZOOLOGICAL SCIENCE, vol. 30, no. 7, 2013, pages 543 - 552, XP009521252, DOI: 10.2108/zsj.30.543 * |
PAIN, B: "Long-term in vitro culture and characterisation of avian embryonic stem cells with multiple morphogenetic potentialities", DEVELOPMENT, 1996, pages 2339 - 2348, XP002164729 * |
Also Published As
Publication number | Publication date |
---|---|
WO2019112161A2 (ko) | 2019-06-13 |
JP7092886B2 (ja) | 2022-06-28 |
US11564951B2 (en) | 2023-01-31 |
US20200384036A1 (en) | 2020-12-10 |
KR20190066888A (ko) | 2019-06-14 |
EP3722414A4 (en) | 2021-10-06 |
JP2021505202A (ja) | 2021-02-18 |
CN111511901A (zh) | 2020-08-07 |
KR102121042B1 (ko) | 2020-06-09 |
EP3722414A2 (en) | 2020-10-14 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2019112161A3 (ko) | 조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물 | |
WO2015168149A3 (en) | Sensorineural hair cell differentiation | |
MX2021013713A (es) | Celulas pluripotentes modificadas. | |
MX2023013435A (es) | Composiciones y metodos para expresar otoferlina. | |
MX2017007196A (es) | Fibroblastos de embrion de pollo inmortalizados. | |
MX2018001827A (es) | Composicion y productos que comprenden celulas senescentes para su uso en la regeneracion de tejidos. | |
WO2016022776A3 (en) | Increasing atoh1 life to drive sensorineural hair cell differentiantion | |
WO2019118518A3 (en) | Inducible cell receptors for cell-based therapeutics | |
EP3521306A4 (en) | FUSION PROTEIN INCLUDING AN IMMOBILIZED PROTEIN HAVING AN INCREASED ANTIOXIDANT FUNCTION, A SKIN CELL PROLIFERATION EFFECT, A HUMAN EPITHELIAL CELL GROWTH FACTOR HAVING AN ENHANCED ANTIOXIDIZING FUNCTION, A SKIN CELL PROLIFERATION EFFECT, A FACTOR FOR THE GROWTH OF HUMAN EPITHELIAL CELLS, AND A COSMETIC COMPOSITION CONTAINING PRINCIPE IN PRIPAUTEIN | |
MY157534A (en) | Composition for skin external application and functional food containing rose placenta tissue culture or extract thereof | |
WO2016159567A3 (ko) | 발모 또는 육모 촉진용 및 항염용 조성물 | |
UY38986A (es) | Compuestos derivados de 3-(5-metoxi-1-oxoisoindolin-2-il) piperidin-2,6-diona, métodos de usos de los mismos y combinaciones farmacéuticas | |
MX2013012045A (es) | Péptidos con actividad antimicrobiana, composiciones farmacéuticas para la profilaxis y el tratamiento de animales, composiciones para la profilaxis y el tratamiento de vegetales, usos de esos péptidos y usos del extracto de paenibacillus elgii ourofinensis. | |
MX2012013478A (es) | Composicion para evitar perdida del cabello o estimular crecimiento del cabello. | |
EP3636275A4 (en) | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF NEOVASCULAR DISEASES WITH TYPE I COLLAGEN AND FACTOR PEPTIDE FROM PIGMENT EPITHELA AS ACTIVE INGREDIENTS | |
EP3360894A4 (en) | FUNCTIONAL REGULATORY ANTIBODY WITH EFFECTS FOR PROMOTING PROLIFERATION, SURVIVAL AND CELL ACTIVATION OF DERMAL PAPILLA CELLS AS HAIR GROWTH REGULATING CENTER CELLS AND THEIR USE | |
WO2014180269A3 (zh) | 间充质干细胞在预防或治疗应激反应导致的免疫力下降中的应用 | |
MX2022001518A (es) | Composiciones que comprenden enzimas digestivas. | |
EP3962502A4 (en) | METHOD FOR TREATING PERIODONTAL DISEASE USING CHARACTERIZED MESENCHYMATE STEM CELL GROWTH FACTORS AND EXOSOMES | |
EP3959306A4 (en) | DIFFERENTIATION OF NOCICEPTORS FROM HUMAN PLURIPOTENT STEM CELLS | |
ZA201907391B (en) | Hydrogels as carriers of active ingredients and methods of producing the same | |
WO2019079698A8 (en) | Tissue products with variations in mechanical properties and methods of treatment | |
BR112017016883A2 (pt) | compostos com atividade antitumoral | |
MX2019012738A (es) | Peptido para inducir la regeneracion de tejido, y uso del mismo. | |
WO2016135732A8 (en) | Method of promoting hair growth |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 18885818 Country of ref document: EP Kind code of ref document: A2 |
|
ENP | Entry into the national phase |
Ref document number: 2020550566 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2018885818 Country of ref document: EP Effective date: 20200706 |