WO2019112161A3 - 조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물 - Google Patents

조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물 Download PDF

Info

Publication number
WO2019112161A3
WO2019112161A3 PCT/KR2018/011852 KR2018011852W WO2019112161A3 WO 2019112161 A3 WO2019112161 A3 WO 2019112161A3 KR 2018011852 W KR2018011852 W KR 2018011852W WO 2019112161 A3 WO2019112161 A3 WO 2019112161A3
Authority
WO
WIPO (PCT)
Prior art keywords
stem cells
cells
wrinkle improvement
skin regeneration
cell proliferation
Prior art date
Application number
PCT/KR2018/011852
Other languages
English (en)
French (fr)
Other versions
WO2019112161A2 (ko
Inventor
이정복
Original Assignee
이정복
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이정복 filed Critical 이정복
Priority to CN201880078775.7A priority Critical patent/CN111511901A/zh
Priority to US16/769,986 priority patent/US11564951B2/en
Priority to JP2020550566A priority patent/JP7092886B2/ja
Priority to EP18885818.7A priority patent/EP3722414A4/en
Publication of WO2019112161A2 publication Critical patent/WO2019112161A2/ko
Publication of WO2019112161A3 publication Critical patent/WO2019112161A3/ko

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/982Reproductive organs; Embryos, Eggs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/981Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of mammals or bird
    • A61K8/985Skin or skin outgrowth, e.g. hair, nails
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0625Epidermal cells, skin cells; Cells of the oral mucosa
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/70Undefined extracts
    • C12N2500/80Undefined extracts from animals
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/02Coculture with; Conditioned medium produced by embryonic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/08Coculture with; Conditioned medium produced by cells of the nervous system
    • C12N2502/088Coculture with; Conditioned medium produced by cells of the nervous system neural stem cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/13Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Cell Biology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

본 발명은 조류의 에그(egg)로부터 분리한 세포인 배반엽 전분화능세포(pluripotent stem cells, PSCs) 또는 신경줄기세포(neural stem cells, NSCs),배아섬유아세포(embryonic fibroblasts, FBs) 컨디션드 배지(conditioned medium)를 유효성분으로 함유하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물에 관한 것으로, 구체적으로 에그(egg) 세포 컨디션드 배지는 동물성 혈청의 사용으로 인한 오염을 원천적으로 차단할 수 있고, 나아가 지지세포 사용으로 인한 이종 간의 감염물질에 의한 전염 가능성 없이, 인간 줄기세포, 피부세포를 포함하는 다양한 세포 증식 효과를 나타내며, 또한 유의적인 피부 재생 또는 주름 개선 효과를 나타내므로, 에그 세포 컨디션드 배지를 세포 증식용 배지 조성물, 및 피부 재생 또는 주름개선용 화장료 조성물로 유용하게 사용될 수 있다.
PCT/KR2018/011852 2017-12-06 2018-10-10 조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물 WO2019112161A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201880078775.7A CN111511901A (zh) 2017-12-06 2018-10-10 包含作为从鸟类的蛋分离的细胞的胚盘多能干细胞、神经干细胞、胚胎成纤维细胞条件培养基作为有效成分的用于细胞增殖、皮肤再生及皱纹改善的培养基组合物
US16/769,986 US11564951B2 (en) 2017-12-06 2018-10-10 Medium composition for cell proliferation, skin regeneration, and wrinkle improvement comprising, as active ingredient, conditioned medium of pluripotent stem cells, neural stem cells, or embryonic fibroblasts which are isolated from avian eggs
JP2020550566A JP7092886B2 (ja) 2017-12-06 2018-10-10 鳥類の卵から分離した細胞である胚盤葉多能性幹細胞、神経幹細胞、胚性線維芽細胞条件培地を有効成分とする細胞の増殖、肌の再生、及びシワ改善用の培地組成物
EP18885818.7A EP3722414A4 (en) 2017-12-06 2018-10-10 MEDIUM COMPOSITION FOR CELL PROLIFERATION, SKIN REGENERATION AND WRINKLE IMPROVEMENT WITH CONDITIONED MEDIUM ISOLATED FROM BIRD EGGS, PLURIPOTENT STEM CELLS, NEURONAL STEM CELLS OR EMBRYONAL FIBROBLASTS AS THE ACTIVE SUBSTANCE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2017-0166745 2017-12-06
KR1020170166745A KR102121042B1 (ko) 2017-12-06 2017-12-06 조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물

Publications (2)

Publication Number Publication Date
WO2019112161A2 WO2019112161A2 (ko) 2019-06-13
WO2019112161A3 true WO2019112161A3 (ko) 2019-07-25

Family

ID=66751034

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2018/011852 WO2019112161A2 (ko) 2017-12-06 2018-10-10 조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물

Country Status (6)

Country Link
US (1) US11564951B2 (ko)
EP (1) EP3722414A4 (ko)
JP (1) JP7092886B2 (ko)
KR (1) KR102121042B1 (ko)
CN (1) CN111511901A (ko)
WO (1) WO2019112161A2 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20210395678A1 (en) * 2018-11-08 2021-12-23 Integriculture Inc. Animal cell growth promoter, culture medium for animal cell culture, and animal cell culture apparatus
CN112755177B (zh) * 2021-03-15 2022-03-18 浙江大学 一种含有鸡胚egf的口服液及制备方法和应用
KR20240083156A (ko) 2022-10-27 2024-06-11 선문대학교 산학협력단 담수 유래의 미세조류 추출물을 유효성분으로 함유하는 피부 주름, 피부 노화, 피부 창상 예방 또는 개선 또는 치료용 조성물
CN116584379B (zh) * 2023-05-04 2024-06-21 广西壮族自治区药用植物园 化橘红组织培养快速繁殖方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830510A (en) * 1992-05-15 1998-11-03 North Carolina State University Veterinary pharmaceutical formulation containing avian embryonic stem cells
WO2012170995A2 (en) * 2011-06-10 2012-12-13 University Of Georgia Research Foundation, Inc. Avian induced pluripotent stem cells and their use
KR20180007256A (ko) * 2016-07-12 2018-01-22 이정복 에그 세포 배양액을 유효성분으로 포함하는 인간 줄기세포 성장용 배지 조성물
KR20180035763A (ko) * 2018-03-26 2018-04-06 이정복 에그 세포 배양액을 유효성분으로 포함하는 인간 줄기세포 성장용 배지 조성물

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
CN101044235B (zh) * 2004-09-08 2013-01-02 威斯康星校友研究基金会 胚胎干细胞的培养基和培养
US20060174362A1 (en) * 2005-02-01 2006-08-03 Origen Therapeutics, Inc. Long-term culture of avian primordial germ cells (PGCs)
CA2656175C (en) * 2006-06-26 2018-08-28 Lifescan, Inc. Conditioned media obtained from amniotic fluid-derived cells for pluripotent stem cell culture
EP1985305A1 (en) 2007-04-24 2008-10-29 Vivalis Duck embryonic derived stem cell lines for the production of viral vaccines
EP2072616A1 (en) 2007-12-17 2009-06-24 Institut National De La Recherche Agronomique Method for reprogramming in vitro stem cells and somatic cells into germinal cells
KR20100096447A (ko) * 2009-02-24 2010-09-02 주식회사 알앤엘바이오 돼지 태반 조직 유래 줄기세포의 배양물 및 그 추출 단백질을 함유한 화장료용 조성물
CN102329771A (zh) * 2011-10-12 2012-01-25 佛山科学技术学院 长期传代培养鸡胚胎干细胞的方法及其专用培养基
AU2012326137B2 (en) * 2011-10-17 2018-11-29 Minerva Biotechnologies Corporation Media for stem cell proliferation and induction
KR20140072676A (ko) * 2012-12-05 2014-06-13 건국대학교 산학협력단 형질전환 닭 역분화 만능줄기세포의 제조방법
CN105246494B (zh) * 2013-04-19 2020-02-07 高丽大学校产学协力团 刺激毛发生长或防止毛发脱落的包括神经干细胞的提取物的组合物及其制造方法
KR20150009898A (ko) * 2013-07-17 2015-01-27 김혜정 인간 지방유래 줄기세포 배양액 추출물을 함유한 화장품 조성물 및 이를 이용한 화장품
WO2015028900A1 (en) * 2013-08-29 2015-03-05 Stempeutics Research Pvt. Ltd. Stromal cells derived conditioned medium, method of obtaining said conditioned medium compositions, formulations and applications thereof
CN106318904B (zh) * 2015-06-15 2020-08-11 上海朗斯生物工程有限公司 间充质干细胞条件培养基用于美容品领域的用途
CN104997708A (zh) * 2015-07-07 2015-10-28 河南中科干细胞基因工程有限公司 干细胞条件培养基的获取及在防皮肤老化方面的应用
CN106511387A (zh) * 2016-10-26 2017-03-22 谢培增 鸡胚胎素制备方法及应用
KR101830062B1 (ko) * 2017-06-30 2018-02-20 주식회사 차바이오텍 피부줄기세포 배양액을 포함하는 피부 노화 예방 또는 개선용 조성물 및 이의 용도

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830510A (en) * 1992-05-15 1998-11-03 North Carolina State University Veterinary pharmaceutical formulation containing avian embryonic stem cells
WO2012170995A2 (en) * 2011-06-10 2012-12-13 University Of Georgia Research Foundation, Inc. Avian induced pluripotent stem cells and their use
KR20180007256A (ko) * 2016-07-12 2018-01-22 이정복 에그 세포 배양액을 유효성분으로 포함하는 인간 줄기세포 성장용 배지 조성물
KR20180035763A (ko) * 2018-03-26 2018-04-06 이정복 에그 세포 배양액을 유효성분으로 포함하는 인간 줄기세포 성장용 배지 조성물

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MACDONALD, JONI: "Characterisation and Germline Transmission of Cultured Avian Primordial Germ Cells", PLOS ONE, 2010, pages e15518, XP055167559, DOI: 10.1371/journal.pone.0015518 *
NAKANOH, SHOTA -§: "Inhibition of MEK and GSK3 supports ES cell -like domed colony formation from avian and reptile embryos", ZOOLOGICAL SCIENCE, vol. 30, no. 7, 2013, pages 543 - 552, XP009521252, DOI: 10.2108/zsj.30.543 *
PAIN, B: "Long-term in vitro culture and characterisation of avian embryonic stem cells with multiple morphogenetic potentialities", DEVELOPMENT, 1996, pages 2339 - 2348, XP002164729 *

Also Published As

Publication number Publication date
WO2019112161A2 (ko) 2019-06-13
JP7092886B2 (ja) 2022-06-28
US11564951B2 (en) 2023-01-31
US20200384036A1 (en) 2020-12-10
KR20190066888A (ko) 2019-06-14
EP3722414A4 (en) 2021-10-06
JP2021505202A (ja) 2021-02-18
CN111511901A (zh) 2020-08-07
KR102121042B1 (ko) 2020-06-09
EP3722414A2 (en) 2020-10-14

Similar Documents

Publication Publication Date Title
WO2019112161A3 (ko) 조류의 에그로부터 분리한 세포인 배반엽 전분화능세포, 신경줄기세포, 배아섬유아세포 컨디션드 배지를 유효성분으로 하는 세포 증식, 피부재생 및 주름 개선용 배지 조성물
WO2015168149A3 (en) Sensorineural hair cell differentiation
MX2021013713A (es) Celulas pluripotentes modificadas.
MX2023013435A (es) Composiciones y metodos para expresar otoferlina.
MX2017007196A (es) Fibroblastos de embrion de pollo inmortalizados.
MX2018001827A (es) Composicion y productos que comprenden celulas senescentes para su uso en la regeneracion de tejidos.
WO2016022776A3 (en) Increasing atoh1 life to drive sensorineural hair cell differentiantion
WO2019118518A3 (en) Inducible cell receptors for cell-based therapeutics
EP3521306A4 (en) FUSION PROTEIN INCLUDING AN IMMOBILIZED PROTEIN HAVING AN INCREASED ANTIOXIDANT FUNCTION, A SKIN CELL PROLIFERATION EFFECT, A HUMAN EPITHELIAL CELL GROWTH FACTOR HAVING AN ENHANCED ANTIOXIDIZING FUNCTION, A SKIN CELL PROLIFERATION EFFECT, A FACTOR FOR THE GROWTH OF HUMAN EPITHELIAL CELLS, AND A COSMETIC COMPOSITION CONTAINING PRINCIPE IN PRIPAUTEIN
MY157534A (en) Composition for skin external application and functional food containing rose placenta tissue culture or extract thereof
WO2016159567A3 (ko) 발모 또는 육모 촉진용 및 항염용 조성물
UY38986A (es) Compuestos derivados de 3-(5-metoxi-1-oxoisoindolin-2-il) piperidin-2,6-diona, métodos de usos de los mismos y combinaciones farmacéuticas
MX2013012045A (es) Péptidos con actividad antimicrobiana, composiciones farmacéuticas para la profilaxis y el tratamiento de animales, composiciones para la profilaxis y el tratamiento de vegetales, usos de esos péptidos y usos del extracto de paenibacillus elgii ourofinensis.
MX2012013478A (es) Composicion para evitar perdida del cabello o estimular crecimiento del cabello.
EP3636275A4 (en) PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF NEOVASCULAR DISEASES WITH TYPE I COLLAGEN AND FACTOR PEPTIDE FROM PIGMENT EPITHELA AS ACTIVE INGREDIENTS
EP3360894A4 (en) FUNCTIONAL REGULATORY ANTIBODY WITH EFFECTS FOR PROMOTING PROLIFERATION, SURVIVAL AND CELL ACTIVATION OF DERMAL PAPILLA CELLS AS HAIR GROWTH REGULATING CENTER CELLS AND THEIR USE
WO2014180269A3 (zh) 间充质干细胞在预防或治疗应激反应导致的免疫力下降中的应用
MX2022001518A (es) Composiciones que comprenden enzimas digestivas.
EP3962502A4 (en) METHOD FOR TREATING PERIODONTAL DISEASE USING CHARACTERIZED MESENCHYMATE STEM CELL GROWTH FACTORS AND EXOSOMES
EP3959306A4 (en) DIFFERENTIATION OF NOCICEPTORS FROM HUMAN PLURIPOTENT STEM CELLS
ZA201907391B (en) Hydrogels as carriers of active ingredients and methods of producing the same
WO2019079698A8 (en) Tissue products with variations in mechanical properties and methods of treatment
BR112017016883A2 (pt) compostos com atividade antitumoral
MX2019012738A (es) Peptido para inducir la regeneracion de tejido, y uso del mismo.
WO2016135732A8 (en) Method of promoting hair growth

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18885818

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2020550566

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2018885818

Country of ref document: EP

Effective date: 20200706