WO2019100902A1 - 一种透皮促渗皮肤美容方法 - Google Patents

一种透皮促渗皮肤美容方法 Download PDF

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Publication number
WO2019100902A1
WO2019100902A1 PCT/CN2018/112010 CN2018112010W WO2019100902A1 WO 2019100902 A1 WO2019100902 A1 WO 2019100902A1 CN 2018112010 W CN2018112010 W CN 2018112010W WO 2019100902 A1 WO2019100902 A1 WO 2019100902A1
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skin
cosmetic
cosmetic composition
penetration enhancing
transdermal penetration
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PCT/CN2018/112010
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English (en)
French (fr)
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徐百
吴国林
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苏州纳通生物纳米技术有限公司
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Publication of WO2019100902A1 publication Critical patent/WO2019100902A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the invention relates to the technical field of skin beauty, in particular to a transdermal skin penetration cosmetic method.
  • the skin is an important organ covering the surface of the human body. It is composed of epidermis, dermis, subcutaneous tissue and accessory organs of the skin. It is a natural barrier between the external environment and the body.
  • One of the important aspects of skin beauty is the application of skin beauty products to the skin surface, so that the nutrients in the beauty products penetrate into the skin.
  • the skin is the outer layer of the human body, its permeability is poor, traditional skin care methods, in the absence of physical microwave, laser, invasive micro-needle and chemical penetration enhancer, skin beauty products are difficult to penetrate the skin and thin
  • the tough cuticle the active ingredient can not reach the target site, the absorption rate is low, only 0.3%.
  • microwave, laser, invasive microneedle and chemical penetration enhancer There are many shortcomings and shortcomings in microwave, laser, invasive microneedle and chemical penetration enhancer. These methods either pierce the skin too deeply to form painful wounds, cause infection, or have toxic side effects and damage skin health.
  • Nano-microneedles and nanochips are being widely used in the field of transdermal delivery devices.
  • Nano-microneedle is a kind of micro-needle that opens the skin tube through nanotechnology.
  • the needle is similar to a small wafer square, which is covered with dense, small, invisible small needles. Press this small square on the skin. It will allow the drug to enter the epidermis, and people have almost no feeling.
  • Nano-wafer is a special nano-seepage tool developed according to human skin structure, which is carved from single crystal silicon through nanotechnology.
  • the surface of the nanochip is a series of microneedle arrays that open the outermost stratum corneum of the skin without damaging the dermis layer and greatly increasing the ability of the delivery medium to penetrate the skin's epidermis.
  • the biocompatibility of single crystal silicon ensures the safety of nanocrystals during use.
  • the invention aims to provide a transdermal penetration-promoting skin cosmetic method, combining the characteristics of nano micro-needle and nano-wafer to design a cosmetic composition, fully combining and exerting the skin care efficacy of the cosmetic composition and the nano-microneedle/nano wafer in the skin care field. Promoting penetration.
  • the technical solution of the present invention is:
  • a transdermal penetration dermal cosmetic method comprising the following steps:
  • the skin is treated with a penetration enhancing cosmetic device prior to, after, or after contact with the skin composition, the permeation cosmetic device being provided with a microdevice for penetrating only the stratum corneum of the skin.
  • a transdermal penetration dermal cosmetic method comprising the following steps:
  • Preparing a mask comprising the cosmetic composition, the mask being printed with lines for indicating direction of use and technique;
  • the skin is treated with a penetration enhancing cosmetic device, and the penetration enhancing beauty device is provided with a micro device for penetrating only the stratum corneum of the skin, and the micro device is slid in the direction indicated by the line on the mask, miniature The device is in contact with the skin through the mask to avoid scratching the skin.
  • the cosmetic composition comprises, by mass percentage, at least one or any combination of the following components:
  • the cosmetic composition comprises the following components in terms of mass percentage:
  • the cosmetic composition further comprises a solvent.
  • the solvent is water.
  • microdevice pierces the stratum corneum of the skin to a length between 4 microns and 2000 microns.
  • micro device is a nano microneedle or a nanochip.
  • the penetration enhancing beauty device comprises a reservoir for accommodating the cosmetic composition, the micro-device of the penetration-enhancing beauty device while flowing out of the reservoir from the reservoir Handle the skin.
  • the capacity of the reservoir is consistent with the amount of primary use of the cosmetic composition.
  • a method for transdermal skin penetration cosmetic treatment as described above for treating chloasma and skin care is described above.
  • the present invention at least includes the following beneficial effects:
  • the invention opens the stratum corneum of the skin through the micro device, so that the skin absorbs the beauty composition more fully, thereby reducing waste and achieving better cosmetic effect;
  • the beauty composition of the invention adopts natural ingredients, has whitening and moisturizing skin, moisturizing and hydrating, supplementing nutrients, promoting wound healing, scavenging free radicals, reducing wrinkles, preventing aging and the like;
  • the cosmetic composition of the present invention can be used to treat the skin before or after contact with the skin, or after contact with the skin, and the method is flexible and diverse, and does not affect the skin care result.
  • the skin care field fully combines and exerts the skin care efficacy of the cosmetic composition and the penetration enhancement of the nano-microneedle/nanochip.
  • the skin is treated with a penetration enhancing cosmetic device having a microdevice for penetrating only the stratum corneum of the skin.
  • the cosmetic composition includes the following components in terms of mass percentage:
  • the cosmetic composition also includes a solvent, and the solvent is water.
  • the micro device pierces the stratum corneum of the skin to a length of 200 microns, and the micro device is a nano microneedle.
  • the penetration enhancing beauty device comprises a reservoir for containing a cosmetic composition which, while flowing out of contact with the skin from the reservoir, treats the skin with a micro device that promotes the beauty device.
  • the capacity of the reservoir is consistent with the amount of use of the cosmetic composition.
  • the skin Prior to contacting the cosmetic composition with the skin, the skin is treated with a penetration enhancing cosmetic device having a microdevice for penetrating only the stratum corneum of the skin.
  • the cosmetic composition comprises the following components in percentage by mass:
  • the cosmetic composition also includes a solvent, and the solvent is water.
  • the microdevice pierces the stratum corneum of the skin at a length of 4 microns, and the micro device is a nanochip.
  • a mask comprising a cosmetic composition, the line printed on the mask for indicating the direction of use and the technique;
  • the skin is treated with a penetration-enhancing cosmetic device, and the micro-device for perforating only the stratum corneum of the skin is provided on the exudation beauty instrument, and the micro-device is slid in the direction indicated by the line on the mask, and the micro-device is transmitted through the mask and the skin. Contact to avoid scratching the skin.
  • the cosmetic composition comprises the following components in percentage by mass:
  • the cosmetic composition also includes a solvent, and the solvent is water.
  • the micro device pierces the stratum corneum of the skin at a length of 2000 microns, and the micro device is a nanochip.
  • Comparative Example 1 used a commercially available beauty product alone
  • Comparative Example 2 used a skin-enhancing beauty instrument in combination with a commercially available beauty product.
  • the tester used a skin elasticity tester and a MicroSkin II multifunctional dermatoscope image analysis system to determine the elasticity and skin texture of the site of use. 5 times per point, averaged.
  • the skin changes were counted and the arithmetic mean roughness change rate (abbreviated as A) and the elastic relative change rate (abbreviated as B) were calculated.
  • Example 1 Example 2
  • Example 3 Comparative example 1 Comparative example 2 A% -25 -twenty two -twenty four -11 -15
  • Example 1 Example 2 Example 3 Comparative example 1 Comparative example 2 B% 30 28 27 8 12
  • the skin smoothness of the present Example 1-3 is higher than that of Comparative Example 1-2, and the rate of change of elasticity is increased, indicating that the transdermal penetration-promoting skin cosmetic method provided by the present invention fully combines and exerts the cosmetic composition.
  • the skin care effect and the nano-microneedle/nano-wafer promoting effect can whiten and moisturize the skin, treat chloasma, moisturize, replenish nutrients, promote wound healing, scavenge free radicals, reduce wrinkles, prevent aging and so on.

Abstract

一种透皮促渗皮肤美容方法，包括以下步骤：配置美容组合物；在将所述美容组合物与皮肤接触前、或接触后、或接触的同时，用促渗美容仪处理皮肤，所述促渗美容仪上设有用于仅穿透皮肤角质层的微型装置。该方法结合纳米微针和纳米晶片的特点设计美容组合物，充分发挥美容组合物的护肤功效和纳米微针/纳米晶片的促渗作用。

Description

一种透皮促渗皮肤美容方法 技术领域
本发明涉及皮肤美容技术领域，具体地是涉及一种透皮促渗皮肤美容方法。
背景技术
皮肤是覆盖于人体表面的一个重要器官，由表皮、真皮、皮下组织和皮肤的附属器官构成，是外界环境和机体之间的一道天然屏障。皮肤美容的重要环节之一是将皮肤美容产品涂抹在皮肤表面，使美容产品中的营养成份渗透入皮肤。但是，皮肤系人体外层防线，其渗透性差，传统美容护肤方法，在不使用物理微波，激光，有创微针和化学促渗剂的情况下，皮肤美容产品难以穿透皮肤皮面薄确坚韧的角质层，有效成分无法抵达目标部位，吸收率低，只有0.3％。而使微波、激光、有创微针和化学促渗剂，存在着诸多弊端和不足，这些方式要么过深刺穿皮肤形成痛感创伤，引发感染，要么有毒副作用，损害皮肤健康。
纳米微针和纳米晶片正被广泛应用在经皮输送器械技术领域。纳米微针是通过纳米技术打开皮肤管道的一种微针，针头类似一块小小的晶片方块，上面布满了密密的、细到看不出来的小针，将这个小方块按在皮肤上，就能让药物进入表皮，而人几乎没有感觉。纳米晶片是根据人体皮肤结构开发的纳米促渗专用工具，由单晶硅经过纳米技术工艺雕刻而成。纳米晶片的表面是一系列微针阵列，它们可以打开皮肤最外面的角质层，同时不会伤及真皮层，大大提高输送介质在皮肤表皮上的渗透能力。单晶硅的生物兼容性又保证了纳晶在使用过程中的安全性。
但是，目前带有纳米微针或纳米晶片的美容仪，配合使用的都是现有的美容产品，其组成和含量是对应于使用者在日常涂覆或是其他类型的美容仪等皮肤渗透能力较弱的情景下使用而设计的，尚未有针对纳米微针和纳米晶片的特点设计的皮肤美容产品。
技术解决方案
本发明旨在提供一种透皮促渗皮肤美容方法，结合纳米微针和纳米晶片的特点设计美容组合物，在护肤领域充分结合和发挥美容组合物的护肤功效和纳米微针/纳米晶片的促渗作用。
为解决上述技术问题，本发明的技术方案是：
一种透皮促渗皮肤美容方法，包括以下步骤：
配制美容组合物；
在将所述美容组合物与皮肤接触前、或接触后、或接触的同时，用促渗美容仪处理皮肤，所述促渗美容仪上设有用于仅穿透皮肤角质层的微型装置。
一种透皮促渗皮肤美容方法，包括以下步骤：
配制美容组合物；
制备包含所述美容组合物的面膜，所述面膜上印刷有用于指示使用方向和手法的线条；
敷上面膜后，用促渗美容仪处理皮肤，所述促渗美容仪上设有用于仅穿透皮肤角质层的微型装置，将所述微型装置按所述面膜上的线条指示方向滑动，微型装置透过面膜与皮肤接触，以避免划伤皮肤。
进一步的，所述美容组合物按质量百分比计包括以下组分中的至少一种或任意组合：
Figure PCTCN2018112010-appb-000001
进一步的，所述美容组合物按质量百分比计包括以下组分：
Figure PCTCN2018112010-appb-000002
进一步的，所述美容组合物还包括溶剂。
进一步的，所述溶剂为水。
进一步的，所述微型装置刺入皮肤角质层的长度在4微米到2000微米之间。
进一步的，所述微型装置为纳米微针或纳米晶片。
进一步的，所述促渗美容仪包括用于容纳所述美容组合物的储存器，所述美容组合物从所述储存器内流出接触皮肤的同时，所述促渗美容仪的所述微型装置处理皮肤。
进一步的，所述储存器的容量与所述美容组合物的一次使用量一致。
一种上述的透皮促渗皮肤美容方法在治疗黄褐斑和护肤中的应用。
有益效果
采用上述技术方案，本发明至少包括如下有益效果：
1、本发明通过微型装置打开皮肤角质层，使皮肤对美容组合物的吸收更加充分，从而减少浪费，达到更好的美容功效；
2、本发明的美容组合物采用天然成分，具有美白和滋润皮肤，保湿补水，补充营养物质，促进创伤愈合，清除自由基，减少皱纹，预防衰老等功效；
3、本发明的美容组合物可以在与皮肤接触前、或接触后、或接触的同时，使用带有微型装置的促渗美容仪处理皮肤，方法灵活多样，都不影响使用的护肤结果，在护肤领域充分结合和发挥美容组合物的护肤功效和纳米微针/纳米晶片的促渗作用。
本发明的最佳实施方式
下面将结合具体实施例对本发明中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1
本实施例的一种透皮促渗皮肤美容方法，包括以下步骤：
配制美容组合物；
在将美容组合物与皮肤接触的同时，用促渗美容仪处理皮肤，促渗美容仪上设有用于仅穿透皮肤角质层的微型装置。
其中，美容组合物按质量百分比计包括以下组分：
Figure PCTCN2018112010-appb-000003
Figure PCTCN2018112010-appb-000004
美容组合物还包括溶剂，溶剂为水。
微型装置刺入皮肤角质层的长度在200微米之间，微型装置为纳米微针。
促渗美容仪包括用于容纳美容组合物的储存器，美容组合物从储存器内流出接触皮肤的同时，促渗美容仪的微型装置处理皮肤。储存器的容量与美容组合物的一次使用量一致。
实施例2
本实施例的一种透皮促渗皮肤美容方法，包括以下步骤：
配制美容组合物；
在将美容组合物与皮肤接触前，用促渗美容仪处理皮肤，促渗美容仪上设有用于仅穿透皮肤角质层的微型装置。
美容组合物按质量百分比计包括以下组分：
Figure PCTCN2018112010-appb-000005
美容组合物还包括溶剂，溶剂为水。
微型装置刺入皮肤角质层的长度在4微米，微型装置为纳米晶片。
实施例3
本实施例的一种透皮促渗皮肤美容方法，包括以下步骤：
配制美容组合物；
制备包含美容组合物的面膜，面膜上印刷有用于指示使用方向和手法的线条；
敷上面膜后，用促渗美容仪处理皮肤，促渗美容仪上设有用于仅穿透皮肤角质层的微型装置，将微型装置按面膜上的线条指示方向滑动，微型装置透过面膜与皮肤接触，以避免划伤皮肤。
美容组合物按质量百分比计包括以下组分：
Figure PCTCN2018112010-appb-000006
Figure PCTCN2018112010-appb-000007
美容组合物还包括溶剂，溶剂为水。
微型装置刺入皮肤角质层的长度在2000微米，微型装置为纳米晶片。
实施例4
本发明实施例1-3的一种透皮促渗皮肤美容方法的护肤效果实验：
1)粗糙度和弹性测试方法：
招募50名中国女性受试者，年龄18-40岁，分成5组，每组10人，每位受试者均被告知整个研究过程，并签署知情同意书。5组受试者分别每天晚上按照实施例1～3的方法进行美容护肤，对比例1为单独使用市售的美容产品，对比例2为使用促渗美容仪并配合使用市售的美容产品，连续使用28天，期间不使用其他护肤产品，正常活动。在使用前及使用28天后，由测试者使用皮肤弹性测试仪及MicroSkinII多功能皮肤镜图像分析系统测定使用部位的弹性及皮肤纹理。每点测5次，取平均值。
2)粗糙度和弹性测试结果：
统计皮肤变化情况，并计算算数平均粗糙度变化率(简记为A)和弹性相对变化率(简称为B)。
其中，算数平均粗糙度变化率(A)＝(使用后平均粗糙度-使用前平均粗糙度)/使用前平均粗糙度，算数平均粗糙度变化率(A)的计算结果如表1所示：
表1算数平均粗糙度变化率(A)
  实施例1 实施例2 实施例3 对比例1 对比例2
A％ -25 -22 -24 -11 -15
弹性相对变化率(B)的计算公式为：弹性相对变化率＝(使用后弹性-使用前弹性)/使用前域弹性，弹性相对变化率(B)的计算结果如表2所示：
表2弹性相对变化率(B)
  实施例1 实施例2 实施例3 对比例1 对比例2
B％ 30 28 27 8 12
由表1-2可知，本实施例1-3相比对比例1-2的皮肤光滑度提升，弹性变化率上升，说明本发明提供的透皮促渗皮肤美容方法充分结合和发挥美容组合物 的护肤功效和纳米微针/纳米晶片的促渗作用，可以美白和滋润皮肤，治疗黄褐斑，保湿补水，补充营养物质，促进创伤愈合，清除自由基，减少皱纹，预防衰老等。
对所公开的实施例的上述说明，使本领域专业技术人员能够实现或使用本发明。对这些实施例的多种修改对本领域的专业技术人员来说将是显而易见的，本文中所定义的一般原理可以在不脱离本发明的精神或范围的情况下，在其它实施例中实现。因此，本发明将不会被限制于本文所示的这些实施例，而是要符合与本文所公开的原理和新颖特点相一致的最宽的范围。

Claims (11)

  1. 一种透皮促渗皮肤美容方法，其特征在于包括以下步骤：
    配制美容组合物；
    在将所述美容组合物与皮肤接触前、或接触后、或接触的同时，用促渗美容仪处理皮肤，所述促渗美容仪上设有用于仅穿透皮肤角质层的微型装置。
  2. 一种透皮促渗皮肤美容方法，其特征在于包括以下步骤：
    配制美容组合物；
    制备包含所述美容组合物的面膜，所述面膜上印刷有用于指示使用方向和手法的线条；
    敷上面膜后，用促渗美容仪处理皮肤，所述促渗美容仪上设有用于仅穿透皮肤角质层的微型装置，将所述微型装置按所述面膜上的线条指示方向滑动。
  3. 如权利要求1或2所述的一种透皮促渗皮肤美容方法，其特征在于：所述美容组合物按质量百分比计包括以下组分中的至少一种或任意组合：
    Figure PCTCN2018112010-appb-100001
  4. 如权利要求3所述的一种透皮促渗皮肤美容方法，其特征在于：所述美容组合物按质量百分比计包括以下组分：
    Figure PCTCN2018112010-appb-100002
  5. 如权利要求3所述的一种透皮促渗皮肤美容方法，其特征在于：所述美容组合物还包括溶剂。
  6. 如权利要求5所述的一种透皮促渗皮肤美容方法，其特征在于：所述溶剂为水。
  7. 如权利要求1或2所述的一种透皮促渗皮肤美容方法，其特征在于：所述微型装置刺入皮肤角质层的长度在1微米到3000微米之间。
  8. 如权利要求1或2所述的一种透皮促渗皮肤美容方法，其特征在于：所述微型装置为纳米微针或纳米晶片。
  9. 如权利要求1或2所述的一种透皮促渗皮肤美容方法，其特征在于：所述促渗美容仪包括用于容纳所述美容组合物的储存器，所述美容组合物从所述储存器内流出接触皮肤的同时，所述促渗美容仪的所述微型装置处理皮肤。
  10. 如权利要求9所述的一种透皮促渗皮肤美容方法，其特征在于：所述储存器的容量与所述美容组合物的一次使用量一致。
  11. 一种如权利要求1-10任意一项所述的透皮促渗皮肤美容方法在治疗黄褐斑和护肤中的应用。
PCT/CN2018/112010 2017-11-27 2018-10-26 一种透皮促渗皮肤美容方法 WO2019100902A1 (zh)

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