WO2019097306A3 - Synthèse de 5-amino-1-(2,6-dichloro-4-trifluorométhyl-phényl)-4-éthylsulfanyl -1 h-pyrazole-3-carbonitrile et composés apparentés - Google Patents

Synthèse de 5-amino-1-(2,6-dichloro-4-trifluorométhyl-phényl)-4-éthylsulfanyl -1 h-pyrazole-3-carbonitrile et composés apparentés Download PDF

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Publication number
WO2019097306A3
WO2019097306A3 PCT/IB2018/001622 IB2018001622W WO2019097306A3 WO 2019097306 A3 WO2019097306 A3 WO 2019097306A3 IB 2018001622 W IB2018001622 W IB 2018001622W WO 2019097306 A3 WO2019097306 A3 WO 2019097306A3
Authority
WO
WIPO (PCT)
Prior art keywords
ethylsulfanyl
carbonitrile
pyrazole
dichloro
trifluoromethyl
Prior art date
Application number
PCT/IB2018/001622
Other languages
English (en)
Other versions
WO2019097306A2 (fr
Inventor
Eran FOGLER
Yehudah Rachamim WISEMAN
Sanaa MUSA
Natalia STRIZHIVER
Michael Grabarnick
Michael MOGILNITSKY
Original Assignee
Adama Makhteshim, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adama Makhteshim, Ltd. filed Critical Adama Makhteshim, Ltd.
Priority to JP2020526565A priority Critical patent/JP2021502991A/ja
Priority to CN201880074242.1A priority patent/CN111386256A/zh
Priority to BR112020009705-5A priority patent/BR112020009705B1/pt
Publication of WO2019097306A2 publication Critical patent/WO2019097306A2/fr
Publication of WO2019097306A3 publication Critical patent/WO2019097306A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La présente invention concerne un procédé de préparation de 5-amino-1-(2,6-dichloro-4-trifluorométhyl-phényl)-4-éthylsulfanyl -1 H-pyrazole-3-Carbonitrile et de composés apparentés.
PCT/IB2018/001622 2017-11-15 2018-11-13 Synthèse de 5-amino-1-(2,6-dichloro-4-trifluorométhyl-phényl)-4-éthylsulfanyl -1 h-pyrazole-3-carbonitrile et composés apparentés WO2019097306A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2020526565A JP2021502991A (ja) 2017-11-15 2018-11-13 ５−アミノ−１−（２，６−ジクロロ−４−トリフルオロメチル−フェニル）−４−エチルスルファニル−１ｈ−ピラゾール−３−カルボニトリル及び関連化合物の合成
CN201880074242.1A CN111386256A (zh) 2017-11-15 2018-11-13 5-氨基-1-(2,6-二氯-4-三氟甲基-苯基)-4-乙基硫烷基-1h-吡唑-3-甲腈及相关化合物的合成
BR112020009705-5A BR112020009705B1 (pt) 2017-11-15 2018-11-13 Processo para preparar um composto e método para obter um composto

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762586342P 2017-11-15 2017-11-15
US62/586,342 2017-11-15

Publications (2)

Publication Number Publication Date
WO2019097306A2 WO2019097306A2 (fr) 2019-05-23
WO2019097306A3 true WO2019097306A3 (fr) 2019-10-17

Family

ID=66379948

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2018/001622 WO2019097306A2 (fr) 2017-11-15 2018-11-13 Synthèse de 5-amino-1-(2,6-dichloro-4-trifluorométhyl-phényl)-4-éthylsulfanyl -1 h-pyrazole-3-carbonitrile et composés apparentés

Country Status (3)

Country Link
JP (1) JP2021502991A (fr)
CN (1) CN111386256A (fr)
WO (1) WO2019097306A2 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232940A (en) * 1985-12-20 1993-08-03 Hatton Leslie R Derivatives of N-phenylpyrazoles
WO1998028278A1 (fr) * 1996-12-24 1998-07-02 Rhone-Poulenc Agrochimie 1-arylpyrazoles pesticides
CH701924B1 (de) * 2010-03-03 2011-03-15 Keki Hormusji Gharda Verfahren zur Synthese von Fipronil.
WO2013037291A1 (fr) * 2011-09-14 2013-03-21 Rotam Agrochem International Company Limited Procédé pour la préparation de composés de pyrazole n-substitués

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE517612C2 (sv) 1995-12-20 2002-06-25 Rhone Poulenc Agrochimie Användning av 5-amino-4-etylsulfinyl-1-arylpyrazol föreningar som pesticider
MX2013000374A (es) 2010-07-12 2013-03-05 Irvita Plant Prot A Branch Of Celsius Property B V Proceso de produccion de fipronilo.

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5232940A (en) * 1985-12-20 1993-08-03 Hatton Leslie R Derivatives of N-phenylpyrazoles
WO1998028278A1 (fr) * 1996-12-24 1998-07-02 Rhone-Poulenc Agrochimie 1-arylpyrazoles pesticides
CH701924B1 (de) * 2010-03-03 2011-03-15 Keki Hormusji Gharda Verfahren zur Synthese von Fipronil.
WO2013037291A1 (fr) * 2011-09-14 2013-03-21 Rotam Agrochem International Company Limited Procédé pour la préparation de composés de pyrazole n-substitués

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
MATHUR: "FORM -2", 11 September 2015 (2015-09-11), XP055591887, Retrieved from the Internet <URL:https://content2.cas.org/v1/AUTH_9a355bb5cefd4c378bde0d541c6a11ce/patentpak-cdr-full-text-9/patent/74897615_1537160410.pdf?temp_url_sig=9f5d4da95a8f428027ef5453ae8b7d24450057f5&temp_url_expires=1558736118&inline> [retrieved on 20190524] *
MEI XU ET AL: "Iron-Catalyzed Direct Sulfenylation and Selenylations of Phenylpyrazoles: Synthesis of Fipronil Derivatives with Disulfides Promoted by a Catalytic Amount of Iodine", SYNTHETIC COMMUNICATIONS, vol. 42, no. 23, 1 December 2012 (2012-12-01), PHILADELPHIA, PA; US, pages 3472 - 3481, XP055591510, ISSN: 0039-7911, DOI: 10.1080/00397911.2011.584262 *
TANG R Y ET AL: "A convenient conversion of pyrazolyl disulfide to sulfides by sodium dithionite and synthesis of sulfoxides", JOURNAL OF FLUORINE CHEMISTRY, ELSEVIER, NL, vol. 127, no. 7, 1 July 2006 (2006-07-01), pages 948 - 953, XP028044214, ISSN: 0022-1139, [retrieved on 20060701], DOI: 10.1016/J.JFLUCHEM.2006.04.002 *

Also Published As

Publication number Publication date
JP2021502991A (ja) 2021-02-04
WO2019097306A2 (fr) 2019-05-23
BR112020009705A2 (pt) 2020-11-03
CN111386256A (zh) 2020-07-07

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