WO2019090244A3 - Analyse in vitro de grappe de cellules suppressives dérivées de myéloïdes - Google Patents

Analyse in vitro de grappe de cellules suppressives dérivées de myéloïdes Download PDF

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Publication number
WO2019090244A3
WO2019090244A3 PCT/US2018/059242 US2018059242W WO2019090244A3 WO 2019090244 A3 WO2019090244 A3 WO 2019090244A3 US 2018059242 W US2018059242 W US 2018059242W WO 2019090244 A3 WO2019090244 A3 WO 2019090244A3
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WO
WIPO (PCT)
Prior art keywords
myeloid
derived suppressor
vitro
suppressor cell
cluster analysis
Prior art date
Application number
PCT/US2018/059242
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English (en)
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WO2019090244A2 (fr
Inventor
Sharon Evans
Scott Abrams
Max Wicha
Original Assignee
Health Research, Inc.
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Publication date
Application filed by Health Research, Inc. filed Critical Health Research, Inc.
Publication of WO2019090244A2 publication Critical patent/WO2019090244A2/fr
Publication of WO2019090244A3 publication Critical patent/WO2019090244A3/fr

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
    • G01N2333/70539—MHC-molecules, e.g. HLA-molecules
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne un procédé d'identification de l'état immunosuppresseur d'un individu comprenant la détection de la formation d'une formation de groupe de cellules suppressives dérivées de myéloïdes circulantes (MDSC) dans un échantillon de sang obtenu à partir d'un individu. La formation de groupe MDSC peut être identifiée dans des frottis sanguins frais ou dans des échantillons de sang par cytométrie de flux.
PCT/US2018/059242 2017-11-03 2018-11-05 Analyse in vitro de grappe de cellules suppressives dérivées de myéloïdes WO2019090244A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762581438P 2017-11-03 2017-11-03
US62/581,438 2017-11-03

Publications (2)

Publication Number Publication Date
WO2019090244A2 WO2019090244A2 (fr) 2019-05-09
WO2019090244A3 true WO2019090244A3 (fr) 2019-06-13

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PCT/US2018/059242 WO2019090244A2 (fr) 2017-11-03 2018-11-05 Analyse in vitro de grappe de cellules suppressives dérivées de myéloïdes

Country Status (1)

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WO (1) WO2019090244A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20220395494A1 (en) * 2019-11-05 2022-12-15 Health Research, Inc. Combination therapy for cancer
EP4264265A1 (fr) * 2020-12-15 2023-10-25 Agency for Science, Technology and Research Procédé destiné à caractériser un neutrophile immunosuppressif
CN114739890B (zh) * 2022-04-15 2022-12-13 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） 人MDSCs在鉴别CAA和AAA中的应用及鉴别试剂盒

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160096892A1 (en) * 2014-07-21 2016-04-07 The Trustees Of The University Of Pennsylvania Treatment of cancer using a cd33 chimeric antigen receptor
US20170112929A1 (en) * 2012-09-07 2017-04-27 Kings College London Vista modulators for diagnosis and treatment of cancer
US20170131285A1 (en) * 2014-06-13 2017-05-11 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for diagnosing, monitoring and treating cancer

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20170112929A1 (en) * 2012-09-07 2017-04-27 Kings College London Vista modulators for diagnosis and treatment of cancer
US20170131285A1 (en) * 2014-06-13 2017-05-11 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and compositions for diagnosing, monitoring and treating cancer
US20160096892A1 (en) * 2014-07-21 2016-04-07 The Trustees Of The University Of Pennsylvania Treatment of cancer using a cd33 chimeric antigen receptor

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
CHEN ET AL.: "Recruitment of CD 11b+Ly6C+ monocytes in non-small cell lung cancer xenografts challenged by anti-VEGF antibody", ONCOL LETT., vol. 14, no. 1, 24 May 2017 (2017-05-24), pages 615 - 622, XP055614931, DOI: 10.3892/ol.2017.6236 *
DING ET AL.: "Critical Role of the mTOR Pathway in Development and Function of Myeloid- Derived Suppressor Cells in lalL/L Mice", AM J PATHOL., vol. 184, no. 2, February 2014 (2014-02-01), pages 397 - 408, XP055614926, DOI: 10.1016/j.ajpath.2013.10.015 *
KOTSAKIS ET AL.: "Myeloid-derived suppressor cell measurements in fresh and cryopreserved blood samples", J IMMUNOL METHODS, vol. 381, no. 1-2, 2012, pages 1 - 22, XP028509497, DOI: 10.1016/j.jim.2012.04.004 *
SINHA ET AL.: "Tumor-Induced Myeloid-derived Suppressor Cell Function is Independent of IFNgamma and IL -4Ra", EUR J IMMUNOL., vol. 42, no. 8, August 2012 (2012-08-01), pages 2052 - 2059, XP055614918, DOI: 10.1002/eji.201142230 *
STANOJEVIC ET AL.: "A subpopulation that may correspond to granulocytic myeloid-derived suppressor cells reflects the clinical stage and progression of cutaneous melanoma", INT IMMUNOL., vol. 28, no. 2, 2015, pages 87 - 97, XP055614924, DOI: 10.1093/intimm/dxv053 *
TUCK ET AL.: "Standard Operating Procedures for Serum and Plasma Collection: Early Detection Research Network Consensus Statement Standard Operating Procedure Integration Working Group", J PROTEOME RES., vol. 8, no. 1, 2009, pages 113 - 117, XP055614928, DOI: 10.1021/pr800545q *
UMANSK Y ET AL.: "The Role of Myeloid-Derived Suppressor Cells (MDSC) in Cancer Progression", VACCINES ( BASEL, vol. 4, no. 4, 3 November 2016 (2016-11-03), pages E36, XP055614921, DOI: 10.3390/vaccines4040036 *

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Publication number Publication date
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