WO2018200995A3 - Systèmes de polybiodétection et d'imagerie orthogonaux - Google Patents

Systèmes de polybiodétection et d'imagerie orthogonaux Download PDF

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Publication number
WO2018200995A3
WO2018200995A3 PCT/US2018/029864 US2018029864W WO2018200995A3 WO 2018200995 A3 WO2018200995 A3 WO 2018200995A3 US 2018029864 W US2018029864 W US 2018029864W WO 2018200995 A3 WO2018200995 A3 WO 2018200995A3
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WO
WIPO (PCT)
Prior art keywords
methods
biological samples
polybiosensing
orthogonal
imaging systems
Prior art date
Application number
PCT/US2018/029864
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English (en)
Other versions
WO2018200995A2 (fr
Inventor
Mandana Veiseh
Pirooz Parvarandeh
S. Bahram Bahrami
Oliver Peter King-Smith
Todd S. Rutherford
Aaron Peter SCHELLENBERG
Timothy Scott Edward HILLER
Original Assignee
Polybiomics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polybiomics, Inc. filed Critical Polybiomics, Inc.
Priority to EP18790804.1A priority Critical patent/EP3615921A4/fr
Priority to CN201880042834.5A priority patent/CN110799830B/zh
Publication of WO2018200995A2 publication Critical patent/WO2018200995A2/fr
Publication of WO2018200995A3 publication Critical patent/WO2018200995A3/fr
Priority to US16/664,537 priority patent/US11338294B2/en
Priority to US17/727,601 priority patent/US20220250056A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/505—Containers for the purpose of retaining a material to be analysed, e.g. test tubes flexible containers not provided for above
    • B01L3/5055—Hinged, e.g. opposable surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/40—Manifolds; Distribution pieces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • G—PHYSICS
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B—PERFORMING OPERATIONS; TRANSPORTING
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    • B01L2300/00—Additional constructional details
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0893—Geometry, shape and general structure having a very large number of wells, microfabricated wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
    • B01L3/5085—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates
    • B01L3/50853—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above for multiple samples, e.g. microtitration plates with covers or lids
    • G—PHYSICS
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    • G01N2035/00346—Heating or cooling arrangements
    • G01N2035/00356—Holding samples at elevated temperature (incubation)
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/251—Colorimeters; Construction thereof
    • G01N21/253—Colorimeters; Construction thereof for batch operation, i.e. multisample apparatus
    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G01N21/783—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour for analysing gases
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    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means

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  • Chemical & Material Sciences (AREA)
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  • Immunology (AREA)
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  • Dispersion Chemistry (AREA)
  • Cell Biology (AREA)
  • Acoustics & Sound (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)

Abstract

Afin de former un système de biodétection-imagerie hybride unique qui peut fonctionner à l'intérieur d'un incubateur, la présente invention concerne des structures et des procédés permettant de placer des biocapteurs modulaires et amovibles et des interfaces biocompatibles dans des puits de test transparents en 3D qui contiennent des échantillons biologiques. La technologie permet une surveillance continue de multiples paramètres et fonctions simultanés d'une cellule vivante ou de groupes de cellules tels que des altérations de ligands cellulaires, des biomarqueurs physico-chimiques, des phénotypes et/ou des compositions extracellulaires lors d'interactions avec des analytes ou pendant des progressions. L'invention concerne également des procédés de capture et d'analyse d'informations orthogonales directes à partir d'échantillons biologiques en 2D et 3D, qui permettent de produire de nouveaux concepts.
PCT/US2018/029864 2017-04-27 2018-04-27 Systèmes de polybiodétection et d'imagerie orthogonaux WO2018200995A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP18790804.1A EP3615921A4 (fr) 2017-04-27 2018-04-27 Systèmes de polybiodétection et d'imagerie orthogonaux
CN201880042834.5A CN110799830B (zh) 2017-04-27 2018-04-27 正交多生物感测和成像系统
US16/664,537 US11338294B2 (en) 2017-04-27 2019-10-25 Orthogonal polybiosensing and imaging systems
US17/727,601 US20220250056A1 (en) 2017-04-27 2022-04-22 Orthogonal polybiosensing and imaging systems

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762491090P 2017-04-27 2017-04-27
US62/491,090 2017-04-27

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US16/664,537 Continuation US11338294B2 (en) 2017-04-27 2019-10-25 Orthogonal polybiosensing and imaging systems

Publications (2)

Publication Number Publication Date
WO2018200995A2 WO2018200995A2 (fr) 2018-11-01
WO2018200995A3 true WO2018200995A3 (fr) 2018-12-06

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PCT/US2018/029864 WO2018200995A2 (fr) 2017-04-27 2018-04-27 Systèmes de polybiodétection et d'imagerie orthogonaux

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EP (1) EP3615921A4 (fr)
CN (1) CN110799830B (fr)
WO (1) WO2018200995A2 (fr)

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USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
US20230047769A1 (en) * 2020-02-19 2023-02-16 Sony Semiconductor Solutions Corporation Biological substance detection chip, biological substance detection device and biological substance detection system
US20210301245A1 (en) * 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
KR102369697B1 (ko) * 2020-05-18 2022-03-03 국민대학교산학협력단 바이오 센싱 모듈, 바이오 센싱 장치, 및 이를 포함하는 바이오 센싱 시스템
EP3943924A1 (fr) * 2020-07-22 2022-01-26 Technische Universität München Plaque de micropuits pour des mesures d'impédance sur des groupes de cellules
US20240019404A1 (en) * 2020-10-15 2024-01-18 University Of Southern California System and method for high-frequency imaging array
CN112415002B (zh) * 2020-11-10 2023-03-14 之江实验室 一种基于图像传感器的多模态传感器件
CN114217208B (zh) * 2021-12-10 2024-04-19 余姚舜宇智能光学技术有限公司 模组测试设备和模组测试设备的测试方法
CN114799495B (zh) * 2021-12-28 2023-06-13 华中科技大学 一种激光切割的控制方法及相关装置
CN114821576A (zh) * 2022-06-30 2022-07-29 之江实验室 一种基于视觉嗅觉协同感知器件的目标识别方法和装置

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US6426615B1 (en) * 1998-02-13 2002-07-30 Shailesh Mehta Apparatus and method for analyzing particles
US6132683A (en) * 1998-12-23 2000-10-17 Matsushita Electric Industrial Co., Ltd. Cell potential measuring electrode and measuring apparatus using the same
US20040209351A1 (en) * 2001-08-30 2004-10-21 Hagen Thielecke Device and method for detecting bioelectric signals from electrophysiologically active regions in spheroids
KR20160124013A (ko) * 2015-04-16 2016-10-26 연세대학교 산학협력단 ３차원 세포 배양 실시간 모니터링 바이오센서

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EP3615921A2 (fr) 2020-03-04
CN110799830B (zh) 2023-04-14
WO2018200995A2 (fr) 2018-11-01
CN110799830A (zh) 2020-02-14
EP3615921A4 (fr) 2021-04-14

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