WO2019087518A1

WO2019087518A1 - Regenerative medical system using breathing method to change oxygen concentration in stages

Info

Publication number: WO2019087518A1
Application number: PCT/JP2018/030286
Authority: WO
Inventors: 隆夫河村
Original assignee: 株式会社グレイトチレン
Priority date: 2017-11-02
Filing date: 2018-08-14
Publication date: 2019-05-09
Also published as: JP2019083888A; TW201922308A; JP6323894B1

Abstract

Dementia is currently regarded as incurable. For patients who develop dementia, to be given the diagnosis without means of treatment is akin to receiving a death sentence. One attempt to change the current situation is this regenerative medical system using a breathing method to change the oxygen concentration in stages. A key point is to initialize the mitochondrial genome and control the generation of reactive oxygen species (ROS), which is generated in brain neurons every day. According to latest results from cell experiments by RIKEN, by increasing the cellular concentration of a reactive oxygen species (hydrogen peroxide) to exactly 2.4 times that of the normal concentration, the mitochondrial genome is initialized during the cell cycle and a change from heteroplasmy to homoplasmy occurs. As a result, mitochondria with reduced functions regain healthy mitochondrial functions. Accordingly, neurons in the brain become capable of producing sufficient energy, greatly improving neurological symptoms. In order to achieve this in vivo, this system uses a special breathing device assembled by combining devices for supplying oxygen gas, nitrogen gas, and hydrogen gas without using expensive drugs or known regenerative medical means, and effects cell regeneration through sequential breathing in a low oxygen concentration range and breathing in a high oxygen concentration range at an appropriate timing for an appropriate duration by means of manual operation or automated programmed control. The age limit for patients to be treated using the system is approximately 120, making this a relatively safe, highly therapeutically effective, and cost-effective advanced regenerative medical system.

Description

Regenerative medicine system using respiratory method to change oxygen concentration stepwise

The present invention relates to a medical device, a medical system, and a medical facility that realize treatment by a respiratory method in which oxygen concentration is gradually changed.

In the context of the present application, on October 28, 2016, a wet high concentration hydrogen mixed gas breathing system was patented as patent 6029044. Using this technology, clinical studies (tests) on neurological disorders, in particular cognitive function, have been conducted for about 20 months or more. As a result, it was found that the therapeutic effect of hydrogen gas on various psychiatric disorders can be expected to delay the progression of symptoms to some extent, but the recovery and cure effect is currently unlikely. On the other hand, in terms of therapeutic agents in this area, pharmaceutical companies are doing research and development of therapeutic agents, but have not yet come to an eye, and in the first place they are conducting research and development based on conventional hypotheses. Even as a result, satisfactory results have not been obtained, and further efforts are needed to clarify the causes and treatments.

Patent No. 5777081 Unexamined-Japanese-Patent No. 2006-325722 Patent No. 6029044

The problem to be solved by the present invention is the establishment of a therapeutic means and a preventive means having a therapeutic or preventive effect on neurological diseases, particularly dementia and the like. Furthermore, use of expensive medicines and cell regeneration medicines such as transplants, not existing medical technologies such as respiratory devices, but developing new therapeutic systems with excellent economic efficiency and safety (research and development) It is.

As described in the background art section, although the therapeutic effect of hydrogen gas on various neurological diseases can be somewhat expected to delay the progression of symptoms, it has been found that the effect of recovering and curing is currently unlikely.

The present inventors diligently investigated various medical related information in order to find out the reason why hydrogen gas is less likely to recover and cure various neurological diseases. As a result, it is pointed out that it is pointed out that phenomena such as functional decline and dysfunction of neurons in intracerebral neurons are always accompanied when symptoms such as neurological diseases, especially dementia appear, and causes of these diseases It was speculated that in part of the brain, mitochondrial dysfunction and dysfunction of intracerebral neurons were involved.
Based on this point of view, the present inventor has been inspired by the possibility that the symptoms may be recovered by improving the mitochondrial function of the brain neuron in a neurological disease.

Therefore, based on Non-Patent Document 1, Non-Patent Document 2, Non-Patent Document 3 and Non-Patent Document 4, the present inventors have made intensive research efforts to time-series oxygen concentration of human respiration by an appropriate method. We found that regulation could improve mitochondrial function of brain neurons.

The present invention for solving the above problems is a gas supply unit capable of supplying a low oxygen gas having at least an oxygen concentration of 18% or less and a high oxygen gas having an oxygen concentration of 21% or more to a human or animal supply target;
And a control unit configured to control the oxygen concentration of the gas supplied from the gas supply unit to the supply target.

ADVANTAGE OF THE INVENTION According to the medical device of this invention, the treatment method and prevention method which have a treatment and prevention effect with respect to a neurological disease, especially dementia etc. can be provided.

In a preferred embodiment of the present invention, the control means controls a time during which a gas having a predetermined oxygen concentration is supplied from the gas supply means to the object to be supplied.
By controlling the time during which the gas is supplied not by human hands but by control means, highly accurate methods for treating or preventing neurological diseases can be realized.

In a preferred embodiment of the present invention, the control means supplies the low oxygen gas to the supply target for 1 to 60 minutes and then supplies the high oxygen gas to the supply target for 10 to 120 minutes. A gas supply unit is controlled.
By controlling the supply order and supply time of the low oxygen gas and the high oxygen gas as described above, a highly effective method for treating or preventing a neurological disease can be provided.

In a preferred embodiment of the present invention, the gas supply unit can supply a gas containing oxygen and nitrogen to the supply target,
The control means controls the oxygen concentration in the gas supplied from the gas supply unit to the supply target by controlling the ratio of nitrogen in the gas supplied.
By controlling the nitrogen content rate, the oxygen concentration of the supplied gas can be adjusted more easily.

In a preferred embodiment of the present invention, an oxygen / nitrogen concentrator capable of separating air into oxygen and nitrogen is provided as a source of oxygen and nitrogen supplied from the gas supply unit.
By using an oxygen / nitrogen concentrator, it is possible to easily generate oxygen and nitrogen contained in the gas.

In a preferred embodiment of the present invention, the gas supply unit can supply a gas containing oxygen and hydrogen to the supply target,
The control means controls the oxygen concentration in the gas supplied from the gas supply unit to the supply target by controlling the ratio of hydrogen in the gas supplied.
By adopting this form, it is possible to reduce the occurrence of side effects in hypoxic respiration and also to desire a health promotion effect by hydrogen inhalation.

In a preferred embodiment of the present invention, a breathing mask for supplying gas to the object to be supplied, a safety exhaust mask arranged to cover the outside of the respiratory mask, and suction for suctioning exhaust from the safety exhaust mask Equipped with
The safety exhaust mask is configured to create a gap with the face to be supplied when the respiratory mask is worn on the face to be supplied.
When the respiratory mask is worn on the face to be supplied and gas is supplied to the object to be supplied, the hydrogen mixed gas leaking from the respiratory mask is aspirated along with the ambient air from the gap between the safety exhaust mask and the face to obtain air. The concentration of hydrogen in the hydrogen mixed gas is lowered by stirring and mixing with the mixture to dilute the concentration of the combustible explosion or less, and the gas is safely exhausted indoors or outdoors.

Thus, safety can be improved by reducing the hydrogen concentration of the hydrogen mixed gas by stirring and mixing with air and exhausting the mixture.

In a preferred form of the invention, there is provided a pulse oximeter for sensing the percutaneous arterial blood oxygen saturation to be delivered,
The control means is connected to the pulse oximeter,
When the control means determines that the transcutaneous arterial blood oxygen saturation of arterial blood toward the brain to be supplied which is sensed by the pulse oximeter is lower than a predetermined value during supply of the hypoxic gas to the supply object. The gas supply unit is controlled to start supply of the high oxygen gas to the supply target.

In this manner, in combination with the pulse oximeter, it is possible to realize more effective and safer treatment or prevention of a neurological disease.

In a preferred embodiment of the present invention, the high pressure chamber capable of containing the object to be supplied is provided, wherein the gas supply unit is a pressurized air supply device, and the pressurized gas from the pressurized air supply device is supplied. It is characterized by
Such a configuration also enables combined use with hyperbaric oxygen therapy.

Further, the present invention provides a medical device as described above,
A transcranial current stimulator having an electrical stimulation unit for applying transcranial electrical stimulation to a head surface of the subject to be supplied, or a low frequency treatment device having an electrode for applying a low frequency current to the subject to be supplied It also relates to medical systems.
The medical system of the present invention enables combined therapy with transcranial direct current stimulation or low frequency treatment.

The present invention provides a medical facility comprising a low oxygen chamber filled with low oxygen gas having an oxygen concentration of 18% or less and a high oxygen chamber filled with high oxygen gas having an oxygen concentration of 21% or more. Also related.
According to the medical equipment of the present invention, an effective method of treating and preventing a neurological disease can be realized.

In a preferred embodiment of the present invention, there is provided a moving body for carrying and moving a human or animal supply target,
The moving body is controlled to move automatically in the low oxygen chamber, the high oxygen chamber, and the outside in response to an instruction from the control unit,
The control unit moves the movable body to the high oxygen chamber after a predetermined time has elapsed in the low oxygen chamber, and the predetermined time has elapsed in the high oxygen chamber. The mobile object is controlled to move to the outside later.

Such a form can provide a more accurate method of treating and preventing neurological diseases for more patients.

According to the medical device, the medical system, and the medical equipment of the present invention, effective treatment or prevention of neurological diseases, in particular, dementia and the like can be realized.

Outline diagram of regenerative medicine system using respiratory method to change oxygen concentration in steps Outline diagram to control generation concentration of reactive oxygen ROS by manual control or program control of inspiratory oxygen concentration Explanatory drawing of the regenerative medicine system using the breathing method which changes oxygen concentration in steps which used the safe exhaust mask together. A device to safely process exhaled breath mixed with high concentration hydrogen gas Illustration of the air concentration separation type oxygen & nitrogen gas feeder as a means of oxygen gas and nitrogen gas supply Improve the existing oxygen concentrator etc. and achieve the purpose Example of a regenerative medicine system using a breathing method in which oxygen concentration is gradually changed. Type using high capacity cannula or venturi mask (Example 1) Example of a regenerative medicine system using a breathing method in which oxygen concentration is gradually changed. A breathing mask is used. The system has been enhanced with a system that is equipped with an exhalation and inspiratory flow meter for detecting the user's breathing volume, and at the same time an exhalation recirculation function can be added. (Example 2) It is an example figure of the regenerative medicine system using the breathing method which changes oxygen concentration in steps using hyperbaric treatment apparatus (example 3). Explanatory drawing of the presumed action mechanism of the regenerative medicine system using the breathing method which changes oxygen concentration stepwise Explanatory diagram of regenerative medicine system using respiratory method to change oxygen concentration stepwise by utilizing partial demand hypoxia state expression of the brain by transcranial direct current electrical stimulation method An illustration of the effect of the amount of mitochondrial energy production on brain activity on neural activity An illustration of blood flow, blood flow distribution, and oxygen consumption for each organ at rest It is an experimental result using the experimental animal (rat) of the production | generation of the brain active oxygen in the hypoxia-reoxygenation process, and the time change of a glucose metabolism. This is an excerpt from the Basic Aging Study 35 (4); 17-26, 2011 (Physiologic Function of Reactive Oxygen, Toru Sasaki, Tokyo Metropolitan Health and Welfare Center Research Institute). It is a figure of a production | generation enhancement of the active oxygen at the time of cancellation | release of demand hypoxia, It is an experimental result using an experimental animal (rat). This is an excerpt from the Basic Aging Study 35 (4); 17-26, 2011 (Physiologic Function of Reactive Oxygen, Toru Sasaki, Tokyo Metropolitan Health and Welfare Center Research Institute). Basic aging study with hypoxia and supply of hypoxia required for anabolism of formation of active oxygen at the time of release of hypoxia 35 (4); 17-26, 2011 (Physiological function of reactive oxygen, Toru Sasaki, Tokyo Health Longevity It is an excerpt from Medical Center Research Institute). It is explanatory drawing of the production | generation model of active oxygen. This is an excerpt from the Basic Aging Study 35 (4); 17-26, 2011 (Physiologic Function of Reactive Oxygen, Toru Sasaki, Tokyo Metropolitan Health and Welfare Center Research Institute). The figure of the process of ROS production and its removal system, excerpt from p411, medicine of oxidative stress, (Diagnostic and therapeutic company) Figure of the cell cycle and the mechanism that regulates it Curler's curve of life FIG. 1 is a diagram of the molecular mechanism of HIF (hypoxia inducible factor) activation by hypoxia. Excerpt from the control mechanism of glucose and lipid metabolism in liver by H. Biol. An illustration of the CO-sensitive H2S signaling pathway discovered as a mechanism of hypoxic vasodilation, where biogas molecules are involved in the defense mechanism of the hypoxic state of the brain, and development of a control method of cerebral ischemic pathologies such as cerebral infarction Hemo, excerpt from Keio University School of Medicine Clarification of the role of IL-6 / IL-21 signal in pulmonary hypertension, clarifying the onset mechanism of pulmonary hypertension, Osaka Osamu Graduate School of Medicine, Department of Internal Medicine (Nursing Cardiology Department) Nakaoka Yoshikazu, Other articles Excerpt from Marginal view of telomere length and mitochondrial activity suggesting the longest life span Regenerative medicine system using respiratory method to change oxygen concentration stepwise in combination with preventive exercise for dementia (Example 4) Regenerative medicine system using a breathing method in which oxygen concentration is gradually changed using a fully automatic controlled motorized wheelchair system for mobile use (Example 5)

Hereinafter, embodiments of the present invention will be described in detail. In the present specification, the medical device, medical system, treatment or prevention by medical equipment of the present invention may be referred to as a regenerative medical system.

As described above, when a symptom such as a neurological disease, especially dementia, appears, a phenomenon called mitochondrial dysfunction of intracerebral nerve cells is always accompanied by dysfunction. Therefore, if the mitochondrial function of brain neurons is improved, symptoms can be recovered.

The mitochondrial electron transport system generally accounts for over 90% of cellular oxygen consumption, of which 1 to 5% is said to be converted to reactive oxygen species, and mitochondrial oxygen concentration is 3 to 10 depending on the supply and consumption of oxygen. It is said to fluctuate in the range of 30 μM. It is said that the amount of active oxygen generation in this nerve cell is different for each individual cell.

In the living body, in particular at least a part of the brain nerve cells, the amount of generation of active oxygen is fluctuated due to the change of the oxygen concentration of the respiration, that is, converted to the concentration of H ₂ O ₂ (hydrogen peroxide) In the process of the user's respiratory gas transitioning from hypoxia to hyperoxia by using this respiratory device, the concentration of reactive oxygen species in brain neurons, here hydrogen peroxide, is 2.4 times the initial concentration. It is possible to make concentration.

As a means for solving the problem, FIG. 1 shows a user (patient) carries out gas breathing with controlled distribution of oxygen, hydrogen and nitrogen by wearing a high flow type cannula or breathing mask as a breathing tool. . This system is a device that separates oxygen and nitrogen in the air and outputs oxygen and nitrogen at an arbitrary ratio, a device that electrolyzes water and takes out hydrogen and oxygen respectively, and controls the amount in time series, manual operation It is configured by a switch or program control device.

FIG. 11 shows experimental data using a rat, and shows how the concentration of reactive oxygen species generated in cells changes by switching the respiratory gas of a target animal from hypoxia to reoxygen (hypoxia) according to a program. Fig. 12 shows the same experimental data using rats, and it is called demand hypoxia and release time when exercise is enhanced and paused, but also when exercise and the like are canceled by a program. It shows how the concentration of reactive oxygen species generated in cells changes, as well as during breathing. In both cases, a portion where the rise of active oxygen reaches 2.4 times appears before and after the change. FIGS. 13 and 14 illustrate the respective states in an easily understandable manner.

FIG. 15 shows how superoxide generated from oxygen in cells is changed to other reactive oxygen species. The conversion to hydrogen peroxide, which is usually relatively stable, is considered to be the majority. In the human body, antioxidants as shown in Table 1 are present. There are various antioxidants such as thioredoxin, glutathione, SOD, vitamin C, etc., and they work to lower the concentration of reactive oxygen species. Table 2 shows reactive oxygen species and antioxidants that remove them. Table 3 is an example showing the concentration in antioxidant metabolites and human serum and the concentration in liver tissue. Thus, the concentration of reactive oxygen species in the body and tissue changes depending on the amount of reactive oxygen species generated and the balance between the time series of the action of eliminating antioxidants in the body and the location (portion) in the body.

The apparatus of FIG. 1 is used to cause the user to first perform hypoxic breathing according to the program setting, and according to the time-series setting, normal oxygen or hyperoxia breathing is performed for the set time after the set time has elapsed. I have to be careful at this time. FIG. 17 is a lifesaving curve of a curler showing the effect of cardiac arrest and respiratory arrest on life support as a function of time. Table 5 shows the oxygen concentration and the influence on the human body. The oxygen concentration and action time of the low oxygen region referring to these data, and the oxygen concentration of the high oxygen region referring to Table 1, Table 2, Table 3, FIG. 11, FIG. 12, FIG. 13, FIG. And determine the action time in a safe range. Also, before and after treatment, it is necessary to avoid intake of vitamin C and the like, which have an antioxidant effect on hydrogen peroxide.

The user is not an absolute condition when using a regenerative medicine system that uses this respiratory method to gradually change the oxygen concentration, but first of all, pulmonary function examination and pathological examination using a spirometer by a respiratory specialist It is desirable to have an examination. Because of the use of a respiratory device, the user's breathing and the ventilation characteristics of the alveoli become a problem. Table 6 shows the respiratory volume and alveolar ventilation for each time. Shallow breathing reduces alveolar ventilation in minutes, and it takes longer to achieve effective hypoxic and hyperoxic areas in the body. In such a case, it is difficult to obtain an effective biological response to the setting in the same time series, and for example, there is a possibility that the regeneration area of the brain cell may be narrowed. As an example of lung function, 5,000 L to 6500 L for adult males and 3500 L to 5000 L for adult females in total displacement = respiratory capacity + respiratory capacity, and this value decreases with age. Therefore, deep and slow breathing is recommended in regenerative medicine systems that use breathing methods that gradually change this oxygen concentration.

The initial setting of the regenerative medicine system using the breathing method that changes the oxygen concentration stepwise is sequence control, the hypoxic region can be set every 20 seconds from the first 1 minute to 10 minutes, and can be set from 10 minutes to 60 minutes It can be set every minute of labor. The oxygen concentration is 18% or less and 0% is theoretically possible, but since there are many risks and no merit can be found, the minimum oxygen concentration is assumed to be around 5%.

As for the effect of hydrogen gas, it was originally aimed at eliminating hydroxy radicals of reactive oxygen species, but in the present application the main purpose is to suppress the awakening of inflammatory cytokines, and the H ₂ and hydrogen gas concentrations in the suction gas are 4 It is possible to operate with a hydrogen concentration of 95% to 90% and an oxygen concentration of 5% to 10% at this time in a short time by adding a special disaster prevention device, with a standard of about%. An oxygen concentration of 21% or more is set in the use of the high oxygen region in the latter part of the sequence, but the upper limit is assumed to be about 60% in consideration of convenience at normal pressure.

Hemoglobin is responsible for the transport of oxygen in the bloodstream, and even if the oxygen concentration is increased, the ability to transport oxygen to living tissue is only an increase in dissolved oxygen based on the partial pressure of oxygen in the alveoli, but from regenerative medicine The situation is different. This is the reason for setting the oxygen concentration to 21% or more.

FIG. 7 is an explanatory view of a presumed action mechanism of a regenerative medicine system using a program-controlled breathing system. The purpose of making the latter part of the sequence a high oxygen area is to further expand the regeneration area of brain cells. The antioxidant power of the living body acts to eliminate or reduce hydrogen peroxide generated in the area of brain cells, and the mitochondrial function is different for each cell and cell by cell, this regenerative medicine mechanism In the operation of this system, the concentration of H ₂ O ₂ hydrogen peroxide generated in the cells must be multiplied by 2.4 for an appropriate period of time during operation of the system, 2.1 or 2. Doubling does not cause mitochondrial genome reprogramming. For this reason, in order to express active oxygen concentration of 2.4 times in a wider area of brain nerve cells, the concentration of oxygen aspirated by the user is increased.

It is desirable that breathing in the high oxygen region be at least 10 minutes or more, and be performed for 30 minutes to 60 minutes. This is because in the living body, the oxidation phenomenon and the (reduction) antioxidant phenomenon are constantly performed by blood flow and various reactions, and it is thought that the value of the active oxygen concentration fluctuates. After this step, oxygen concentration is around 21%, hydrogen concentration is 5% to 10% in the range of 20 minutes to 60 minutes as stabilization completion breathing to prevent excessive response (side effects, hypersensitivity reaction) of the living body. Inhalation breathing is desirable.

In FIG. 7, it is also found that the brain has selective vulnerability and is susceptible to oxidative stress at the site of selective vulnerability. The regenerative medical system appears to act early on this site of selective vulnerability. Moreover, the treatment of the present regenerative medical system including the hypoxic region is considered to develop hypoxia tolerance of the brain, not ischemia tolerance of the brain.

On the other hand, Fig. 16 is a diagram showing the cell cycle and the mechanism that regulates it in "Reset Mechanism of Mitochondrial Genome" at RIKEN, but according to such cell cycle (division phase M), It is supposed that the initialization of the genome is done. Table 4 is a table showing the cell replacement rate and metabolism in the living body. In the brain, the early part of the replacement is 40% in one month, and by continuing the treatment using the present invention at a pace such as every day or twice a day, brain neurons having reduced mitochondria are obtained. At least a part of them can be regenerated into mitochondrial cell neurons having a normal function. At other parts of the living body, the cell tissue and cell cycle differ depending on the target part, and the state of arterial blood also differs, so it is necessary to set up and devise each part.

The regenerative medical system using the respiratory method of gradually changing the oxygen concentration of the present invention can be said to be a hidden homeostasis (bioconstituent system) or cell regeneration system originally provided to the human body. Therefore, it is a system in which a side effect etc. are comparatively hard to occur. In principle, it is useful for treatment and prevention of all diseases caused by mitochondrial dysfunction and dysfunction, and also for the treatment and prevention of diseases caused by generation of reactive oxygen species by mitochondrial dysfunction. It is useful.

Table 7 is a current comparison of other treatment regimens for neurological disorders such as dementia. In the pharmaceutical agent's treatment efforts, the treatment of inflammatory substances that accumulate in the brain with dementia, substances such as amyloid β and tau protein is the decisive factor, but even if they are processed (decreased) There is no noticeable improvement in brain function. On the other hand, if treatment is performed using a regenerative medicine system that uses a breathing method in which oxygen concentration is gradually changed, improvement in brain function is expected (but this is an increase in ATP production function due to improvement in mitochondrial function, However, if the amount of amyloid β, tau protein, etc. already increased and registered inside the brain, can they be reduced by the treatment method of the present application? Is unknown. If tau protein etc. increase, there is a concern that the immune function may be enhanced or oxidative stress may increase, and this is due to the efforts of pharmaceutical companies and the regenerative medicine system using the respiratory method to change oxygen concentration in stages. It can have a relationship.

As other regenerative medicines, SB 623 (Sanbio) and MA-5 (Tohoku University) say that SB 623 is a surgical procedure to administer regenerative cell drugs into the brain and MA-5 improves the mitochondrial function itself Although both treatments are different in that the therapeutic substance is administered to the living body, they are relatively time-consuming treatments. The method of the present application only changes the existing breathing method, and the mechanism is simple and the application is relatively simple.

Muse cells, iPS artificial pluripotent stem cells, muse cells and the like are also expected technologies for future neurological diseases, but the problem is whether it can be set inexpensively in terms of price.

Various types of exercise therapy for preventing dementia have an aspect that leads to the action mechanism of the present application, and active oxygen is also produced in brain neurons through exercise, and initialization of mitochondrial genome occurs in very few neurons, and the result , It is thought that the mitochondrial function of cells is improved.
The evidence is that if you take vitamin C before exercise, there are multiple messages if the improvement effect of physical function by exercise disappears. By complementing the ambiguous part of the action mechanism of exercise therapy with the theory of the present application, the efficiency of exercise therapy seems to be significantly enhanced.

Furthermore, as shown in Table 7 and Table 8, the regenerative medical system using the respiratory method in which the oxygen concentration is gradually changed uses the hypoxic respiratory region to cause the vasodilator action of FIG. 20, various actions by activation of HIF (hypoxia inducible factor) shown in FIG. 18, myocardial division promotion, myocardial regeneration, suppression of ROS generation, addition of hydrogen gas, low in FIG. TNF-α, interleukin IL-1β, IL-6, IL-10, IL-12, CCL2, interferon (TNF-α, IL-6, IL-10, IL-12, CCL2, interferon) by suppressing pulmonary hypertension caused by oxygenemia etc. and suppressing the gene expression of inflammatory cytokines and hormones There is an action to reduce the expression of IFN) -γ, intercellular adhesion molecule 1 (ICAM-1), PGE1, PGE2, etc. Also, as the target age for treatment, a regenerative medicine system using a respiratory method that changes oxygen concentration stepwise utilizes the cell cycle, so its limit, the limit of the heiflick in FIG. It seems that treatment of is possible.

Furthermore, a regenerative medicine system using a breathing method that changes oxygen concentration stepwise is used in combination with transcranial direct current stimulation therapy of the brain as shown in FIG. 8 or in combination with low-power extracorporeal shock wave therapy of the heart. It can be used in combination with acupuncture, in which demand hypoxia is expressed in a part of the body, or in combination with hydrogen peroxide drip therapy or hyperbaric oxygen therapy. In addition, therapy etc. which apply a load to a partial area of the living body in an appropriate manner include massage, acupressure, low frequency treatment device, thermotherapy and the like. FIG. 10 shows an example of blood flow and blood distribution of each organ at the time of human body rest and oxygen consumption. With regard to the initialization of the mitochondrial genome of cells relative to parts other than the brain, fluctuations in the oxygen concentration of alveoli throughout the respiration, individually for each organ or region, are the changes in active oxygen of each cell tissue through the bloodstream of each blood vessel. It is possible to apply to parts other than the brain if the state given to the fluctuation is predicted and calculated. Therefore, a regenerative medicine system using a breathing method in which oxygen concentration is gradually changed is not limited to prevention and treatment of dementia, and is relatively safe and easy to use for regeneration of mitochondrial function of human cells, and others It contributes to regenerative medicine that is achieved inexpensively compared to

When treatment with this regenerative medical system is performed for a certain period, the function of mitochondria of neurons in the brain is enhanced, and brain neurons can use more energy than before. This change appears in neural activity as an improvement in cognitive ability and memory. In FIG. 9, the case where the energy expression of the nerve cell is low is A, the case of a standard energy state is B, and the higher state is C. In clinical experiments, when the brain is in a low energy state, the amount of energy that brain neurons can use as awareness / cognitive activity per unit time is small in A, so there are few recognizable levels or frequencies, and changes in the surrounding area should be made. It reduces the accuracy and frequency of recognition of surrounding events. Also, since the standard recognition level is B, it is impossible to know what it is without knowing about the speed of surrounding change. It is difficult to express something or think about it because there is not enough energy to activate neurons. On the other hand, if the energy expression level of brain neurons is increased by treating with this system for a sufficient period of time, it will be in a state like C, and the amount of energy available for unit time will increase as neural activity. In this state, the change in surrounding events can be grasped as if the accuracy and frequency of recognition of surrounding events are significantly improved. In the C state, nerve cells in the brain can also perform multitasking in neural activity, and when the human being in the A state becomes like C, the number of awareness and recognition per unit time increases, so when the nerve is concentrated in the surroundings, Sometimes the movement of things is felt slow. For example, this is the difference between viewing 10 frames per second and viewing 30 frames per second. Although this is speculation in clinical experiments, although individual differences may be considered, utilization of the present system by patients with dementia etc. can be expected to significantly improve cognitive function and memory ability.

A description will be given of an embodiment in which a mixed gas of nitrogen gas and hydrogen gas is supplied to the supply target in addition to oxygen gas.
In this embodiment, a cannula (high flow rate type) or a respirator such as a respirator or a respirator face mask for suctioning oxygen gas, nitrogen gas and hydrogen gas, nitrogen gas supply means, and oxygen gas supply An air-concentrated oxygen and nitrogen feeder is provided as a means. Furthermore, an MEA water electrolysis type hydrogen gas generator or a hydrogen gas supply device is provided as a hydrogen gas supply means, and oxygen gas of about 50% of the generation amount of hydrogen gas is simultaneously supplied.

These are transported to a mask or the like of the user's mouth by a tube or hose. If the program controller and controller that control the supply amount and timing of oxygen gas, nitrogen gas and hydrogen gas, and a cannula are used for breathing, and if the concentration of hydrogen gas to be supplied exceeds 10%, A variable motorized breath agitating and discharger, which combines the ambient air and exhaled air from the mask with a safety exhaust mask in the form of a cannula and collects it, and discharges the hydrogen concentration of the mixed exhalation to 4% or less. If a hose or tube, depending on the situation, reuses exhalation and adds a conditioning gas (oxygen, hydrogen, etc.) to this, the carbon dioxide adsorbing portion (absorber) on the extension of the exhalation line )).

If necessary, install an inspiratory volume meter and an expiratory flow meter on each line, and install an expiratory gas flow direction switching valve in the necessary part. And for the sake of safety, it consists of a hydrogen gas concentration sensor for monitoring that the indoor hydrogen gas concentration does not exceed 4%. Usually, the breathing gas supply part is made in one package.

What is important is the content of the program, and when the user wears a breathing apparatus and receives treatment, he must always start with a hypoxic area with an oxygen concentration of 18% or less, under conditions that the patient can adapt, and then After each appropriate time has elapsed, the operation is changed to breathing in an oxygen concentration region of 21% or more of oxygen concentration manually or automatically. After this, take an action stabilization respiration so that the intracellular concentration of reactive oxygen species hydrogen peroxide stays around 2.4 times in the high oxygen region for an appropriate period of time, and further increase the oxygen concentration to 21% gradually It ends with the stabilized respiration for the end, which drops the concentration of reactive oxygen species in the cell to near the initial value. The series of operations are manually controlled or automatically controlled by a program control device. The setting contents for each user can be input to the program control device in advance by the setting remote controller.

If you want to control part of the process with the value of this percutaneous arterial blood oxygen saturation by attaching (pasting) a reflection type pulse oximeter to the common carotid artery (preventing excessive hypoxia in cerebral arterial blood Because this SpO2 signal is input to the program control device, interrupt processing can be performed. (Requires prior remote control settings) In this way, the existing respiratory equipment is largely remodeled, and by adopting a special breathing method, the restoration of function of the mitochondria, which can be called regeneration of the cells, is achieved, which is very effective. We have realized a highly safe, regenerative medical system using a breathing method that changes oxygen concentration gradually.

Particularly preferred embodiments of the invention described above are as follows.
<1> A gas supply unit capable of supplying a low oxygen gas having at least an oxygen concentration of 18% or less and a high oxygen gas having an oxygen concentration of 21% or more to a human or animal supply target;
Control means for controlling the oxygen concentration of the gas supplied from the gas supply unit to the supply target;
The control means controls a time during which a gas having a predetermined oxygen concentration is supplied from the gas supply unit to the supply target;
After the control means first supplies the low oxygen gas to the supply target, the high oxygen gas is supplied to the supply target for 10 minutes or more, and thereafter the gas supply is terminated. What is claimed is: 1. A medical system for enhancing the concentration of active oxygen in a brain nerve cell, comprising controlling a gas supply unit.

<2> The control means first supplies the low oxygen gas to the supply target for one minute or more, and then supplies the high oxygen gas to the supply target for ten minutes or more, and then supplies the gas. The medical system according to <1>, wherein the gas supply unit is controlled to end.

<3> A gas supply unit capable of supplying a low oxygen gas having at least an oxygen concentration of 18% or less and a high oxygen gas having an oxygen concentration of 21% or more to a human or animal supply target;
Control means for controlling the oxygen concentration of the gas supplied from the gas supply unit to the supply target;
After the control means first supplies the low oxygen gas to the supply target, the high oxygen gas is supplied to the supply target for 10 minutes or more, and thereafter the low oxygen gas is not supplied. And controlling the gas supply unit in such a manner as to improve the concentration of active oxygen in a brain nerve cell.

<4> The control means first supplies the low oxygen gas to the supply target for one minute or more, and then supplies the high oxygen gas to the supply target for ten minutes or more, and then the low oxygen gas The medical system according to <3>, wherein the gas supply unit is controlled so as not to supply air.

<5> The gas supply unit can supply a gas containing oxygen and nitrogen to the supply target,
The control means controls the oxygen concentration in the gas supplied from the gas supply unit to the supply target by controlling the ratio of nitrogen in the gas supplied, <1> to <4. The medical system according to any one of>.

<6> An oxygen / nitrogen concentrator capable of separating air into oxygen and nitrogen is provided as a source of generation of oxygen and nitrogen supplied from the gas supply unit. <1> The medical system as described in any one of <5>.

<7> The gas supply unit can supply a gas containing oxygen and hydrogen to the supply target,
The control means controls the oxygen concentration in the gas supplied from the gas supply unit to the supply target by controlling the ratio of hydrogen in the gas supplied, <1> to <6. The medical system according to any one of>.

<8> A breathing mask for supplying a gas to the supply target, a safety exhaust mask disposed so as to cover the outside of the respiratory mask, and suction means for suctioning exhaust from the safety exhaust mask.
The safety exhaust mask is configured to create a gap with the face to be supplied when the respiratory mask is worn on the face to be supplied.
When the respiratory mask is worn on the face to be supplied and gas is supplied to the object to be supplied, the hydrogen mixed gas leaking from the respiratory mask is aspirated along with the ambient air from the gap between the safety exhaust mask and the face to obtain air. The medical system according to <7>, wherein the hydrogen concentration of the hydrogen mixed gas is reduced by stirring and mixing with it to dilute it to a concentration below the flammable explosion concentration, and the inside of the room or the outside is safely ventilated.

<9> Equipped with a pulse oximeter that detects percutaneous arterial blood oxygen saturation to be supplied.
The control means is connected to the pulse oximeter,
While the control means is configured to supply the low oxygen gas to the supply target, when the percutaneous arterial blood oxygen saturation level of the supply target sensed by the pulse oximeter is lower than a predetermined value, The medical system according to any one of <1> to <8>, wherein the gas supply unit is controlled to start supply of the high oxygen gas.

<10> The gas supply unit includes a pressurized air supply device, and includes a high pressure chamber capable of containing the object to be supplied, to which the pressurized gas from the pressurized air supply device is supplied. The medical system according to any one of <1> to <9>.

<11> A transcranial current stimulator having an electrical stimulation unit for applying transcranial electrical stimulation to the head surface of the delivery target, or a low frequency treatment device having an electrode for applying a low frequency current to the delivery target The medical system according to any one of <1> to <10>, which is characterized by the above.

<12> An active oxygen concentration improver in a brain nerve cell, comprising a low oxygen gas having an oxygen concentration of 18% or less and a high oxygen gas having an oxygen concentration of 21% or more,
The low oxygen gas is first supplied to a human or animal supply target, and then the high oxygen gas is supplied to the supply target for 10 minutes or more, and then used so as not to be supplied to the supply target. , Reactive oxygen concentration improver in brain neurons.

<13> An active oxygen concentration improver in a brain nerve cell, comprising a low oxygen gas having an oxygen concentration of 18% or less and a high oxygen gas having an oxygen concentration of 21% or more,
After the low oxygen gas is first supplied to a human or animal supply target, the high oxygen gas is supplied to the supply target for 10 minutes or more, and thereafter the low oxygen gas is not supplied to the supply target. An agent for improving the active oxygen concentration in brain neurons, characterized in that.

<14> The agent for improving active oxygen concentration in brain neurons according to <12> or <13>, which is used for the treatment of a neurological disease.

<15> A medical system comprising a low oxygen chamber filled with low oxygen gas having an oxygen concentration of 18% or less and a high oxygen chamber filled with high oxygen gas having an oxygen concentration of 21% or more. ,
A moving body for carrying and moving a supply target of human or animal,
The moving body is controlled to move automatically in the low oxygen chamber, the high oxygen chamber, and the outside in response to an instruction from the control unit,
The control unit moves to the high oxygen chamber after a predetermined time in the low oxygen chamber, and moves to the outdoor after 10 minutes or more in the high oxygen chamber. A medical system characterized by controlling a mobile so as to move.

<16> A low oxygen gas of at least an oxygen concentration of at least 18% is first supplied to a human or animal supply target, and then a high oxygen gas of an oxygen concentration of 21% or higher is supplied for at least 10 minutes. A method for improving the active oxygen concentration in a brain nerve cell, characterized by not supplying oxygen gas and the high oxygen gas.

<17> A low oxygen gas of at least an oxygen concentration of at least 18% is first supplied to a human or animal supply target, and then a high oxygen gas of an oxygen concentration of 21% or higher is supplied for at least 10 minutes. A method for improving the concentration of active oxygen in brain neurons, characterized by not supplying oxygen gas.

<18> A low oxygen gas of at least an oxygen concentration of at least 18% is first inhaled into a human or animal supply target, and then a high oxygen gas having an oxygen concentration higher than that of the atmospheric gas is inhaled for at least 10 minutes. A method for improving the active oxygen concentration in brain neurons, characterized in that the low oxygen gas and the high oxygen gas are not inhaled.

<19> A low oxygen gas having at least an oxygen concentration of at least 18% is first supplied to a human or animal supply target, and then a high oxygen gas having an oxygen concentration of at least 21% is supplied for at least 10 minutes. Use of the low oxygen gas and the high oxygen gas as an active oxygen concentration improver in a brain nerve cell characterized by not supplying the oxygen gas and the high oxygen gas.

<21> A low oxygen gas having at least an oxygen concentration of at least 18% is first supplied to a human or animal supply target, and then a high oxygen gas having an oxygen concentration of at least 21% is supplied for at least 10 minutes. Use of the low oxygen gas and the high oxygen gas as an active oxygen concentration improver in a brain nerve cell characterized by not supplying oxygen gas.

<22> A low oxygen gas having at least an oxygen concentration of at least 18% is first supplied to a human or animal supply target, and then a high oxygen gas having an oxygen concentration of at least 21% is supplied for at least 10 minutes. Use of the low oxygen gas and the high oxygen gas for the production of a reactive oxygen concentration improver in a brain nerve cell characterized by not supplying the oxygen gas and the high oxygen gas.

<23> A low oxygen gas of at least an oxygen concentration of at least 18% is first supplied to a human or animal supply target, and then a high oxygen gas of an oxygen concentration of 21% or higher is supplied for at least 10 minutes. Use of the low oxygen gas and the high oxygen gas for the production of a reactive oxygen concentration improver in a brain nerve cell characterized by not supplying oxygen gas.

Example 1
FIG. 4 is an explanatory view of a first embodiment of the present invention. 1 indicates the head of the user and 2 indicates brain cells. Reference numeral 20 denotes an oxygen gas, nitrogen gas and hydrogen gas supply unit, which is an integrated gas generator. In the air, hydrogen and oxygen are generated from water (distilled water) by electrolysis, a part using an MEA electrolysis cell for water electrolysis, and oxygen and nitrogen are concentrated and separated from air, and taken out, air concentration separation type oxygen and The nitrogen supply unit is integrated into one package.

First of all, the user is diagnosed with a respiratory specialist when using it, and it is confirmed that there is no particular disorder in the respiratory system and the use is started. In order to control the operation of the electrolytic hydrogen / oxygen generating portion and the air concentration separation type oxygen / nitrogen supplying portion inside the 20, there are 21 program control devices to control the on / off of the machine and the generated output. It is the setting remote control controller 22 that sets the control contents of 21. 22 is also used when performing a manual operation. The setting contents of 21 are nitrogen gas mixed with a small amount (several percent) of oxygen and setting of supply amount (generation amount) of hydrogen gas per minute (operation amount) to create a low oxygen respiration region with an oxygen concentration of 18% or less. Settings are made. As the amount of nitrogen-hydrogen mixed gas generation increases, the concentration of oxygen breathed by the user decreases. Since the user mixes and aspirates the nitrogen-hydrogen mixed gas mixed with the trace amount of oxygen and the air around the mask, the relationship between the gas supply per minute from the device and the minute alveolar ventilation volume by respiration The resulting low oxygen concentration breathing is performed.

As the minute alveolar ventilation increases, so does the amount of air entrained from around the mask, the oxygen concentration gets closer to the oxygen concentration of the air, and if the minute alveolar ventilation decreases, the supply of gas Close to oxygen concentration. Therefore, paying attention to this point, the user is urged to secure the respiratory rate.

In addition to this method, the concentration of oxygen to be inhaled can be made constant only with the supplied gas from 20 without being largely influenced by the alveolar ventilation volume per minute, but it can be mixed beforehand with the required oxygen concentration. It is possible to supply such a gas in a sufficient amount so that the air around the mask does not mix, but the burden on the operation of the apparatus is increased.

The safety exhaust mask for exhalation is used when the concentration of hydrogen in the gas drawn by the user exceeds 10%, and within that the flow of the room air of the user is created (air flow) (small fan etc.) I am securing my safety. (This is considered to be more than 4% as a general safety idea of hydrogen gas, but in actual experiments, the hydrogen gas concentration mixes with the surrounding air when it is released from the mask, and the stirring drops rapidly, If the hydrogen concentration of the aspirated gas exceeds 10%, the hydrogen gas concentration is reduced to 4% or less by 17 electric breather and aspirator when the hydrogen concentration exceeds 10% because safety is maintained. Release indoors etc. A hydrogen gas sensor is contained in the inside of 17 and when the suction hydrogen gas concentration exceeds 4%, the suction output is automatically increased in multiple steps to keep the hydrogen gas concentration of the released gas at a safe concentration. The air used in the 20 devices is taken in from the 26 air intakes and released out of the machine through the 27 gas outlets for oxygen, nitrogen and hydrogen gas waste. In addition, there are 25 hydrogen gas concentration sensors in the detection of hydrogen gas concentration in the room of the work space, and if the hydrogen concentration outside the machine exceeds 4%, an alarm is output to automatically stop the system operation. The interface is built in. Reference numeral 24 is used to adjust the temperature and humidity of the gas sucked by the user, and the gas sucked by the user is bubbled in water or hot water to achieve the purpose. The temperature of the gas to be sucked in is preferably about body temperature, but depending on the environmental temperature (room temperature), there is no problem even at a slightly lower temperature, but if humidity is possible it is recommended to be slightly lower than saturated steam.

Generally, a cannula using a nostril has an applied gas volume of about 6 liters per minute, but in the present application, an internal cross-sectional area is approximately doubled to enable suction at an acceptable range of about 10 liters per minute Applied. The operation of the system is covered by the multistage setting of the timer with the passage of time, the on / off of each element of the 20 and the output control, and the control of the internal switching valve by the instruction of the system. Attached to the common carotid artery and perform interrupt control with the user's value of percutaneous arterial blood oxygen saturation, and set the time or the value of percutaneous arterial blood oxygen saturation, whichever is earlier, and then the next stroke You can go to This is a safety measure to prevent the oxygen saturation of arterial blood from being excessively lowered for the purpose of securing the safety of the user. Since the user can not attach (paste) the pulse oximeter to the common carotid artery, it is performed by a medical worker. Although the pulse oximeter which measures with a fingertip etc. can be used only at rest and is not suitable for contents which change from moment to moment as in this application, it measures the common carotid artery, and It is possible to monitor changes in the arterial arterial oxygen saturation. This method is not necessary for every use, and is useful for grasping the trend in the first few times.

To explain the actual situation of use, the user mounts the cannula in the nostril. Next, the medical worker makes 22 settings, but in the actual treatment, the user's health condition is roughly grasped, first make 20 in the standby state, and then air for about 3 minutes every minute Starting from 2L, air is gradually blown into the nostril at 10L per minute, and a preliminary examination of the user's judgment on the suitability of using a cannula is performed. At this point, it is easily determined if the next treatment is possible. If there is no problem, the medical staff performs the first setting, but manually or by program control. The initial hypoxic setting is from 18% to 14% oxygen and time starts from 2 minutes. (If you set oxygen concentration 14% or less, select 1 minute) This selection is determined in consideration of the user's tolerance. Next, as a high oxygen region, a mixed gas of about 3 to 5 liters of oxygen gas per minute and a hydrogen gas of about 800 cc per minute are caused to be sucked by the user for about 10 minutes with a cannula. Consider this degree as the first time. This level is not yet curative.

It can be done once to three times a day (morning, noon, evening), but if it is treated heavily, it is preferable to take it once a day. Each time, the time of the low oxygen region is lengthened, and the oxygen concentration is gradually reduced. The oxygen concentration in the hypoxic region starts from at least 5% (1 to 3 minutes: determined by your own hypoxia tolerance) SPO2 = 80 to 85, and after 5 to 15 seconds, the end of hypoxic breathing, immediately reoxygenation or high Change to the oxygen region.

The hypoxic region requires up to a total stroke of 60 minutes, the high oxygen region requires a minimum of 30 minutes or more, and the recommendation is 50 minutes. The shorter the hyperoxic region, the less the therapeutic effect, and the longer the therapeutic effect is, the more the therapeutic effect increases.

Example 2
FIG. 5 is an explanatory view 2 of the embodiment of the present invention. The method of treatment is the same as in Example 1, but the machine and system of the hardware are complicated. The main difference is that the user's aspirating therapeutic gases all rely on the supply from the integrated gas generator with 31 breath recirculation functions. Thus, the respirator used is a closed mask. The exhaled breath is recirculated to remove the carbon dioxide in the exhaled breath with 32 adsorbents and adjusted by adding the necessary ingredients in the process at that time, to be used for aspiration or when there is no need for recirculation Is safely released to the outside by the operation of the 37 gas flow direction switching valves.

Although the system of the present application can be used as an artificial respiration system, what is displayed in the present application is the treatment of the user's spontaneous breathing. Therefore, it is necessary to encourage the person to breathe with high alveolar ventilation volume per minute, and the decrease in alveolar arousal efficiency by respiration means slowing of the in vivo reaction rate in this treatment, characteristic of time and active oxygen generation. Changes in the waveform of the curve may be more gradual, leading to a reduction in the therapeutic effect. Therefore, a sensor 36 is provided to know in real time the exhalation amount of the breathing currently performed by the user during treatment. The 28 lines include check valves, and the 40 intake flow meters include hydrogen and oxygen concentration sensors.

If the flow rate difference between 40 and 36 continues for a few seconds while the system is operating, the system will judge that the gas leaks from the mask, and give an alarm and shut it down. In addition, when the hydrogen concentration of the suction gas is higher than a certain standard, it is possible to incorporate the detonation arrester into 35. If the user's exhaled volume during treatment falls short of the registered expiratory volume by a certain amount in a short time average, the system displays that the respiratory volume is low. Also, the registration of the standard expiratory volume can be registered in advance by using 36 sensors. The difference from the other example 1 is that the radio technology is applied in terms of hardware. In addition, the outline of the specifications of this device is, as an example, the maximum generation amount of hydrogen gas per minute, 2.4 L, the maximum generation amount of oxygen gas is 9.0 L, the generation amount of nitrogen gas 30 L (estimate) power within about 2 KW It has become.

Then, regarding the effect of the treatment of this example, one example of the clinical experiment result is briefly described.
In the case of a cerebral infarction patient, six months after the onset, there was a slight paralysis on the right hand side, but more problems with memory and cognitive ability appeared. Therefore, in order to create a hypoxic condition, using a Phillips-type sealed nasal mask, a large amount of hydrogen gas was used to inhale low-oxygen gas and breathe.

The center of respiration is the onset of hypoxia for about 5 minutes. It took 60 minutes to 90 minutes including the subsequent reoxygenation step (the step of breathing in and breathing normal air). The minimum exhaled oxygen concentration for a very short time was about 5%.

The change felt in the eye as it was a room experiment in about 5 to 10 minutes starting. I notice that the light of the fluorescent light has muted to some extent red. This work continued for about 40 days.

Then, from the middle, I came to feel the change in the nerve. First, I felt my eyes and eyes were uplifting. Although my eyesight has not improved, what I am watching has changed, and the image of my vision has changed very finely. It felt like it had changed from an old TV to a 4K LCD TV. However, my vision has not improved. Further experiments were continued using another apparatus. Memory ability is greatly improved in short-term memory called working memory.

There is almost no forgetting to put things in everyday life. Furthermore, the change in cognitive ability identified 40 days before the start of the clinical trial resulted in a surprising and incredible change.
The method of confirmation was done by sitting in the front row of the public transport route bus and observing the outside landscape changing as the bus progresses. Before the experiment, the transition of the surrounding traffic was not able to follow the transition or change of the event, but in the 40 days after the clinical trial, it was just when the bus stopped near the intersection, but the surrounding crowded When focusing attention on any three points (three places), such as the movement of other vehicles to the pedestrians, on bicycles, each movement changes in a comprehensible manner as if it were picked up by hand.

And, speaking of movements of pedestrians and bicycles, when I concentrated my awareness at one point and concentrated my vision, I felt that those movements would change slowly as if I saw them in slow motion. Therefore, I felt that the nerve cells inside the brain, especially around the hippocampus, were activated and regenerated by the breathing method that reoxygenates from hypoxic respiration and the oxygen concentration is gradually changed.
The hippocampus area is a particularly vulnerable part of the brain, and it can be said that it responded early to oxygen deficiency or hypoxia.

After that, the second half of hypoxic breathing treatment was not reoxygenation, but was changed to respiration by high oxygenation, that is, high oxygen concentration region (oxygen concentration of 21% or more). In the previous experiments, the working memory improved remarkably, but the connection from the short-term memory area to the long-term memory area was not functioning well, but in order to improve this part, the wider part of the brain was activated It was necessary to make it a policy, and the policy for that was breathing in the high oxygen area.

At first, after trying about 60 minutes of breathing only for hyperoxia for about 2 weeks, and considering the results, it is indeed possible to shift from short-term memory to long-term memory relatively smoothly. Therefore, short-term memory, long-term memory, and cognitive ability were each further evolved when breathing in the high-oxygen area was continuously performed for about 60 minutes from breathing in the low-oxygen area, and evaluation was performed after 30 days.

Functionally and functionally, the brain is above the level of a standard human being rather than the condition before the onset of cerebral infarction, and judging from the rate of its change, reprogramming of the mitochondrial genome of brain cells is The time response and the presumed effect are virtually in agreement with the theory, assuming that the restoration of neural cell mitochondria during the cell cycle division and the improvement of neural cell function occur.

This time, I used a spotlight on the brain cells, but this relationship also holds true for other organs, so I would like to plan clinical trials on different occasions.

Example 3
FIG. 6 shows Example 3. In Example 3, the oxygen partial pressure in the high oxygen concentration region is further increased, and the user with low generation of active oxygen, the patient with low reactivity, etc. After breathing, use the hyperbaric treatment device. Since the pressurization time is about 15 minutes, in terms of time, high pressure oxygen therapy for about 60 minutes is performed by combining pressurization time and decompression time. After hyperbaric oxygen treatment is completed, stabilized breathing is carried out for about 30 minutes at normal pressure for preventing side effects including hydrogen gas.

Furthermore, recent hyperbaric oxygen therapy devices are not filled with oxygen gas in the inner space to be pressurized, but it is also known that some patients use air for pressurization and use oxygen for breathing for patients. In that case, breathing of the hypoxic region can also be performed using this mask.

Example 4
FIG. 22 is a combination of the regenerative medicine system using the breathing method of gradually changing the oxygen concentration according to the present invention after exercise therapy for preventing dementia, and it is possible to remarkably enhance the preventive effect of dementia by exercise therapy. It is possible. In FIG. 22, there are two closed rooms in the facility for exercise therapy, two walkways connecting the two rooms, a door and an access door which can seal each other, a door at the entrance to each indoor playground from each room, and not shown. Is composed of an indoor environment control device that manages the temperature and humidity internal gas components of each sealed room.

In FIG. 22, the user (several persons) who finished the preventive exercise and exercise therapy immediately opens and closes the sealing door of the entrance from the outside and enters the inside of the low oxygen concentration treatment room. Here, after the time determined for each individual in the hypoxic region, the contact door is opened and closed to enter the next high oxygen concentration treatment room, and breathing in the high oxygen region is performed for about 40 to 60 minutes. Do. After finishing, open the door of the exit and go out to the original indoor playground. The treatment in the present application is now over.

Users should avoid taking vitamin C and other antioxidants before exercise. Setting the oxygen concentration in the low oxygen treatment room, because the user is already in the condition of low demand for demand, will add supplyable low oxygen condition in this room, so even if the oxygen concentration is higher than the normal setting Good. The hydrogen concentration in the room is normally set to 4% unless there is a special requirement. Also, carbon dioxide generated by breathing in the room is removed by the carbon dioxide adsorbent inside the indoor environment control device. The high oxygen concentration treatment room is depicted here in a standing position, but it takes a long time to sit in a chair for treatment. Since users can use this treatment room from time to time, if the user group is divided into groups and the exercise therapy is performed group by group, many users can receive the treatment of the present application efficiently. Is possible.

Example 5
Fig. 23 shows an example of a large-scale treatment system using a fully automatic electric wheelchair, which connects a closed hypoxic region treatment room and a closed low oxygen region treatment room through a closed passage, and the example of the embodiment is It is. The treatment starts when all the users sit on a motorized wheelchair 42 that is controlled automatically. The user who always uses a wheelchair also changes to this 42 and receives treatment. Of course, healthy people are also. It is easy to understand if you think that this 42 is an evolution of the professional pilot chair developed by Nissan Motor.

On the floor of each of the

enclosed passages

45, 46 and 47, sensors for positional information are embedded. Position information sensors are also embedded in the 60 and 61 treatment room floors. Further, an electromagnetic charging device for charging the electric wheelchair is installed on the floor at an appropriate position of the electric wheelchair at a fixed position of the floor 61 and a position for stopping the electric wheelchair (parking). The hatched box in the square represents the electric wheelchair and its number.

At this time, the closed door at the back is closed when the closed door at the entrance can be opened automatically for use by the 42nd user. The closed door between 45 and 60 is interlocked to be opened when the inlet door is closed. Normally, the door between each room or passage is controlled by the system so that both do not necessarily open. When this is all open, it is only emergency or emergency. It is possible to have three members in each communication passage.

Ten users can be enrolled in the 60 rooms. There are 40 users in the 61 rooms. The difference in this number is that 60 hypoxic therapeutic units estimate a hydrogen concentration of 4% with an oxygen concentration between 18% and 14%, and the maximum occupancy time for users is assumed to be within 15 minutes. In contrast, in the 61 high oxygen area treatment rooms, the maximum enrollment time of the users is assumed to be 60 minutes or less. Therefore, it is balanced by the treatment ability by treatment time. In the 61 treatment rooms, oxygen concentration is assumed to be between 30% and 40%. The 53 and 54 low-oxygen area and high-oxygen area treatment rooms have an environmental management system to control the gas balance, temperature, humidity and air flow in each treatment room, but comprehensive management is not shown , There is a comprehensive management system by computer.

Here, when the 56th user uses this system for the first time, the in-room breathing time of 60 treatment rooms starts from the minimum. Similarly, the in-room breathing time of 61 treatment rooms is also minimized. Now, assuming 60 treatment rooms for 5 minutes each and 61 treatment rooms for 20 minutes, the treatment time for this user is 25 minutes plus the time required for movement, which usually ends in about 5 minutes in 30 minutes. Now consider the treatment results of the user, and if there are no problems, gradually increase the time each time.

Looking at the plan view, there is a passage of the electric wheelchair around the registered position of the electric wheelchair, and each electric wheelchair can exit the passage without being blocked by the other electric wheelchairs. If the entrance passage and the exit passage are managed, smooth operation is possible. Even if the individual attendance time is different for each individual, since the integrated management system by computer controls the order and timing of movement, a process without waste can be implemented.

However, there is always an accident. A wireless pulse oximeter is attached to this electric wheelchair for the nuclear user, and necessary signal data can be remotely monitored. If there is an abnormality, only that user will give priority to the emergency and give an outdoor priority. Can be transported to In the case of an emergency, in the case of an individual emergency, each passage is opened and transported to the outside of the treatment room via the closest passage because it takes precedence over other operations. In emergency situations such as earthquakes and fires nearby, all doors and all 44 emergency doors of all treatment rooms and communication paths are released by control of the system, and the electric wheelchair is moved out from the nearest location Or, if the hazard location is near, the system will direct you to move the powered wheelchair to the safest location.

In the 61 treatment rooms, the battery for the electric wheelchair can be charged as needed because of the relatively long working breathing time. (Electromagnetic induction charging)
In the case where the electric wheelchair breaks down and can not move, it is also moved out between the other processes by an automatic transport car for moving out of the broken vehicle which moves automatically in the same manner. Before that, an empty electric wheelchair goes for the rescue of the user, carries the user, and carries out the subsequent process of the user.

In the equipment shown in FIG. 23, it is possible to treat about 40 to 70 patients and users at one time. It operates eight hours a day and can treat 320 to 560 people. If you treat 500 people a day, it will be possible to treat and prevent 10,000 people in 20 days. This system is an excellent system with a balance of safety and efficiency, which is very useful not only for dementia but also for many diseases caused by mitochondrial dysfunction.

Using a special respirator manufactured by combining devices that supply oxygen gas, nitrogen gas, and hydrogen gas, using various masks, etc. and breathing with a low oxygen region with an oxygen concentration of 18% or less and subsequent oxygen By performing respiration by a high oxygen region with a concentration of 21% or more under program automatic control under appropriate conditions, it is possible to evoke the initialization of mitochondrial genome of the cell relatively safely and efficiently. This regenerative control system using a program-controlled respiratory system can change the mitochondrial function, which has been reduced through the initialization of the genome of the mitochondrial, into a healthy function through the cell cycle, and the mitochondrial function is reduced or the mitochondria is reduced. It is possible to ameliorate the symptoms of any disease that develops as a result of Especially in dementia, it has the ability to improve cognitive ability and memory. Currently, pharmaceutical companies have not found effective means, and there is also the problem of soaring treatment costs in other regenerative medicine. Among them, the present invention has been completed as an advanced regenerative medical system by combining existing respiratory equipment and the like and adding progressive system settings thereto. It is relatively safe and has excellent treatment efficiency. As it is configured to withstand mass production, it can play a sufficient role as a central entity in future regenerative medicine.

1 Human body, head (user of regenerative medicine breathing apparatus by program control)
2 Brain 3 Common carotid artery 4 Reflective pulse oximeter (wired or wireless)
5 Lung 6 High flow type cannula 7 Inspiratory tube for cannula 8 Respiratory mask (sealed type)
8a Exhalation-intake junction or exhalation-inspiration switching mechanism (hydrogen gas concentration is 10% or more, detonation arrester can be incorporated 9 inhalation passage 10 exhalation passage, exhaust passage 11 inhalation gas, inhalation gas (hydrogen gas, nitrogen gas, oxygen gas)
12 breath (including hydrogen gas)
13 Exhalation Agitation Discharger (Exhale air and exhalation with agitation mixing)
14 Hydrogen gas supply unit (water electrolysis type hydrogen generator)
15 Oxygen gas and nitrogen gas supply section, (Air concentration separation type)
16 exhaust line (tube or hose) high concentration hydrogen mixture for exhalation 17 expiratory agitating and releasing device which mixes and discharges indoor air and exhalation 18 oxygen gas & nitrogen gas supply device (air concentration separation type)
20 Integrated gas generator of oxygen gas & nitrogen gas & hydrogen gas (variable generation capacity type)
21 Program controller 22 Program controller setting remote control controller 23 Signal cable between remote controller and program controller 24 Supply gas temperature adjustment & humidifier (water or hot water bubbling type)
25 hydrogen gas concentration sensor 26 air intake 27 gas outlet inside the integrated generator 28 gas supply line 28a for high flow type cannula gas supply line for venturi mask 29 signal cable for reflection type pulse oximeter 30 program control device Control cable 31 with integrated gas generator Integrated gas generator 32 with exhalation recirculation function Carbon dioxide adsorption unit (litho lime etc)
33 Sealed-type oral and nasal mask 34 Sealed-type face mask 35 Exhalation-intake junction (can incorporate detonation arrester at high hydrogen concentration)
36 O2 concentration meter & exhalation flow meter 37 Gas outflow direction switching valve 38 Wireless LAN (WiFi) type program control device 39 Control cable to integrated gas generator 40 Intake amount sensor 42 Electric wheelchair (automatic operation control type: rechargeable type) Evolvable Pro-Pilot Chair 43 Self-opening and closing door 44 Emergency: Self-opening and closing door 45. Closed entrance passage to low oxygen area treatment room 46. Closed area communication path from low oxygen area treatment room to high oxygen area treatment room 47 Sealed outlet passage 48 from high oxygen area treatment room Left side passage 49 of high oxygen area treatment room Central passage 50 of high oxygen area treatment room 50 Right side passage 51 of high oxygen area treatment room 51 treatment room of sealed structure 52 electric motor Automatic delivery vehicle for carrying out a broken vehicle of wheelchair (automatic operation control) 53 Gas supply system for low oxygen area treatment room (environment management system )
54 Gas supply system for high oxygen area treatment room (environmental management system)
55 Indoor wireless LAN antenna unit 56 Users (sitting)
60 hypoxic area treatment room 61 hyperoxic area treatment room

Claims

A gas supply unit capable of supplying a low oxygen gas having at least an oxygen concentration of 18% and a high oxygen gas having an oxygen concentration of at least 21% to a human or animal supply target;
Control means for controlling the oxygen concentration of the gas supplied from the gas supply unit to the supply target;
The control means controls a time during which a gas having a predetermined oxygen concentration is supplied from the gas supply unit to the supply target;
After the control means first supplies the low oxygen gas to the supply target, the high oxygen gas is supplied to the supply target for 10 minutes or more, and thereafter the gas supply is terminated. What is claimed is: 1. A medical system for enhancing the concentration of active oxygen in a brain nerve cell, comprising controlling a gas supply unit.
The control means first supplies the low oxygen gas to the supply target for one minute or more, and then supplies the high oxygen gas to the supply target for ten minutes or more, and then ends the gas supply. The medical system according to claim 1, wherein the gas supply unit is controlled as follows.
A gas supply unit capable of supplying a low oxygen gas having at least an oxygen concentration of 18% and a high oxygen gas having an oxygen concentration of at least 21% to a human or animal supply target;
Control means for controlling the oxygen concentration of the gas supplied from the gas supply unit to the supply target;
After the control means first supplies the low oxygen gas to the supply target, the high oxygen gas is supplied to the supply target for 10 minutes or more, and thereafter the low oxygen gas is not supplied. And controlling the gas supply unit in such a manner as to improve the concentration of active oxygen in a brain nerve cell.
The control means first supplies the low oxygen gas to the supply target for one minute or more, and then supplies the high oxygen gas to the supply target for ten minutes or more, and then supplies the low oxygen gas. The medical system according to claim 3, characterized in that the gas supply unit is controlled not to perform.
The gas supply unit can supply a gas containing oxygen and nitrogen to the supply target,
5. The apparatus according to claim 1, wherein the control means controls the oxygen concentration in the gas supplied from the gas supply unit to the supply target by controlling the ratio of nitrogen in the gas supplied. The medical system according to any one of the preceding claims.
The oxygen / nitrogen concentrator having separation ability to separate air into oxygen and nitrogen is provided as a generation source of oxygen and nitrogen supplied from the gas supply unit. The medical system according to one or more items.
The gas supply unit can supply a gas containing oxygen and hydrogen to the supply target,
7. The apparatus according to claim 1, wherein the control means controls the oxygen concentration in the gas supplied from the gas supply unit to the supply target by controlling the ratio of hydrogen in the gas supplied. The medical system according to any one of the preceding claims.
The respiratory mask for supplying gas to the supply target, a safety exhaust mask disposed to cover the outside of the respiratory mask, and suction means for suctioning exhaust from the safety exhaust mask;
The safety exhaust mask is configured to create a gap with the face to be supplied when the respiratory mask is worn on the face to be supplied.
When the respiratory mask is worn on the face to be supplied and gas is supplied to the object to be supplied, the hydrogen mixed gas leaking from the respiratory mask is aspirated along with the ambient air from the gap between the safety exhaust mask and the face to obtain air. The medical system according to claim 7, characterized in that the hydrogen concentration of the hydrogen mixed gas is lowered by dilution with stirring and diluted to a concentration equal to or less than the combustible explosion concentration, and the inside of the room or the outside is safely ventilated.
It has a pulse oximeter that senses the target arterial blood oxygen saturation to be delivered.
The control means is connected to the pulse oximeter,
While the control means is configured to supply the low oxygen gas to the supply target, when the percutaneous arterial blood oxygen saturation level of the supply target sensed by the pulse oximeter is lower than a predetermined value, The medical system according to any one of claims 1 to 8, characterized in that the gas supply unit is controlled to start supply of the high oxygen gas.
The apparatus according to claim 1, wherein the gas supply unit includes a pressurized air supply device, and a high pressure chamber capable of containing the object to be supplied, to which the pressurized gas from the pressurized air supply device is supplied. The medical system according to any one of 1 to 9.
A transcranial current stimulator having an electrical stimulation unit for applying transcranial electrical stimulation to a head surface of the subject to be supplied, or a low frequency treatment device having an electrode for applying a low frequency current to the subject to be supplied The medical system according to any one of claims 1 to 10.
It is an active oxygen concentration improver in brain neurons comprising a low oxygen gas having an oxygen concentration of 18% or less and a high oxygen gas having an oxygen concentration of 21% or more,
The low oxygen gas is first supplied to a human or animal supply target, and then the high oxygen gas is supplied to the supply target for 10 minutes or more, and then used so as not to be supplied to the supply target. , Reactive oxygen concentration improver in brain neurons.
It is an active oxygen concentration improver in brain neurons comprising a low oxygen gas having an oxygen concentration of 18% or less and a high oxygen gas having an oxygen concentration of 21% or more,
After the low oxygen gas is first supplied to a human or animal supply target, the high oxygen gas is supplied to the supply target for 10 minutes or more, and thereafter the low oxygen gas is not supplied to the supply target. An agent for improving the active oxygen concentration in brain neurons, characterized in that.
The agent for improving active oxygen concentration in brain neurons according to claim 12 or 13, which is used for the treatment of a neurological disease.
A medical system comprising: a low oxygen chamber filled with low oxygen gas having an oxygen concentration of 18% or less; and a high oxygen chamber filled with high oxygen gas having an oxygen concentration of 21% or more,
A moving body for carrying and moving a supply target of human or animal,
The moving body is controlled to move automatically in the low oxygen chamber, the high oxygen chamber, and the outside in response to an instruction from the control unit,
The control unit moves to the high oxygen chamber after a predetermined time in the low oxygen chamber, and moves to the outdoor after 10 minutes or more in the high oxygen chamber. A medical system characterized by controlling a mobile so as to move.
The low oxygen gas of at least an oxygen concentration of at least 18% is first supplied to the human or animal supply target, and then the high oxygen gas of an oxygen concentration of 21% or higher is supplied for 10 minutes or more. A method for improving the concentration of active oxygen in a brain nerve cell, characterized by not supplying the high oxygen gas.
The low oxygen gas of at least an oxygen concentration of at least 18% is first supplied to a human or animal supply target, and then the high oxygen gas of an oxygen concentration of 21% or higher is supplied for 10 minutes or more. A method for improving the concentration of active oxygen in brain neurons, characterized in that no supply is performed.
The target of human or animal supply is first inhaled low oxygen gas with an oxygen concentration of at least 18%, then high oxygen gas with higher oxygen concentration than atmospheric gas is inhaled for at least 10 minutes, and then the low oxygen A method for improving the concentration of active oxygen in brain neurons, characterized in that the gas and the high oxygen gas are not inhaled.
The low oxygen gas of at least an oxygen concentration of at least 18% is first supplied to the human or animal supply target, and then the high oxygen gas of an oxygen concentration of 21% or higher is supplied for 10 minutes or more. Use of the low oxygen gas and the high oxygen gas as an active oxygen concentration improver in a brain nerve cell characterized by not supplying the high oxygen gas.
The low oxygen gas of at least an oxygen concentration of at least 18% is first supplied to a human or animal supply target, and then the high oxygen gas of an oxygen concentration of 21% or higher is supplied for 10 minutes or more. Use of the low oxygen gas and the high oxygen gas as a reactive oxygen concentration improver in a brain nerve cell characterized in that the supply is not performed.
The low oxygen gas of at least an oxygen concentration of at least 18% is first supplied to the human or animal supply target, and then the high oxygen gas of an oxygen concentration of 21% or higher is supplied for 10 minutes or more. Use of the low oxygen gas and the high oxygen gas for the production of an active oxygen concentration improver in brain neurons, wherein the high oxygen gas is not supplied.
The low oxygen gas of at least an oxygen concentration of at least 18% is first supplied to a human or animal supply target, and then the high oxygen gas of an oxygen concentration of 21% or higher is supplied for 10 minutes or more. Use of the low oxygen gas and the high oxygen gas for the production of a reactive oxygen concentration improver in a brain nerve cell characterized in that the supply is not performed.