TW201922308A - Regenerative medical system using breathing method to change oxygen concentration in stages - Google Patents

Abstract

Dementia is currently regarded as incurable. For patients who develop dementia, to be given the diagnosis without means of treatment is akin to receiving a death sentence. One attempt to change the current situation is this regenerative medical system using a breathing method to change the oxygen concentration in stages. A key point is to initialize the mitochondrial genome and control the generation of reactive oxygen species (ROS), which is generated in brain neurons every day. According to latest results from cell experiments by RIKEN, by increasing the cellular concentration of a reactive oxygen species (hydrogen peroxide) to exactly 2.4 times that of the normal concentration, the mitochondrial genome is initialized during the cell cycle and a change from heteroplasmy to homoplasmy occurs. As a result, mitochondria with reduced functions regain healthy mitochondrial functions. Accordingly, neurons in the brain become capable of producing sufficient energy, greatly improving neurological symptoms. In order to achieve this in vivo, this system uses a special breathing device assembled by combining devices for supplying oxygen gas, nitrogen gas, and hydrogen gas without using expensive drugs or known regenerative medical means, and effects cell regeneration through sequential breathing in a low oxygen concentration range and breathing in a high oxygen concentration range at an appropriate timing for an appropriate duration by means of manual operation or automated programmed control. The age limit for patients to be treated using the system is approximately 120, making this a relatively safe, highly therapeutically effective, and cost-effective advanced regenerative medical system.

Description

   Regenerative medical system using breathing method that changes oxygen concentration stepwise   

The present invention relates to a medical device, a medical system, and a medical device that realize treatment using a breathing method that changes the oxygen concentration stepwise.

In connection with the present invention, the wet high-concentration hydrogen mixed gas breathing system was registered as a patent on October 28, 2016 as Japanese Patent No. 6029044. This technology has been used in clinical studies (trials) related to neurological disorders, particularly cognitive function, for more than 20 months. As a result, although the therapeutic effect of hydrogen on various mental illnesses may be expected to delay symptoms more or less, it has also been found that the effect of restoring a cure is unlikely in the current situation. On the other hand, if we focus on therapeutic drugs in this area, although pharmaceutical companies are conducting research and development of therapeutic drugs, there is no clue. Fundamentally, research and development based on previous assumptions, the results of clinical trials are all Unsatisfactory results cannot be obtained. It can be seen that the explanation of the cause and treatment method requires further efforts.

[Prior technical literature]

[Patent Literature]

Patent Document 1: Japanese Patent No. 5778081.

Patent Document 2: Japanese Patent Application Laid-Open No. 2006-325722.

Patent Document 3: Japanese Patent No. 6029044.

[Non-patent literature]

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The problem to be solved by the present invention is to determine and establish a treatment method and a prevention method having a therapeutic or preventive effect on neurological diseases, especially dementia. Furthermore, it does not use expensive medicines or cell regenerative medicine such as transplantation, but uses existing technology development (research and development) such as breathing machines to create a new treatment structure with excellent economics and safety.

As described in the column of the background art, although the therapeutic effect of hydrogen on various neurological diseases is expected to delay the symptoms more or less, it is found that the effect of restoring the cure is unlikely under the current situation.

The present inventors conducted intensive investigations on various medical-related information in order to study the reason that the possibility of using hydrogen to recover and cure various neurological diseases is low. As a result, it has been pointed out that the symptoms of neurological diseases, especially dementia, must be accompanied by dysfunction and insufficiency of the mitochondria of nerve cells in the brain. In view of this situation, it is speculated that one of the causes of these diseases and Mitochondria of nerve cells in the brain are related to hypofunction and insufficiency.

Based on this focus, the present inventors have conceived that if the mitochondrial function of cerebral nerve cells in neurological diseases is improved, symptoms may be restored.

Therefore, based on Non-Patent Literature 1, Non-Patent Literature 2, Non-Patent Literature 3, and Non-Patent Literature 4, the present inventors have made intensive research efforts and found that if a suitable method is used for the breathing of human beings, the oxygen concentration of the breathing is sequentially controlled. , Can improve the mitochondrial function of brain nerve cells.

The present invention that solves the above-mentioned problems is a medical device including a gas supply unit capable of supplying at least low oxygen with an oxygen concentration of 18% or less and high oxygen with an oxygen concentration of 21% or more to a human or animal supply target; and A mechanism for controlling an oxygen concentration of a gas supplied from a gas supply unit to a supply target.

According to the medical device of the present invention, it is possible to provide a treatment method and a prevention method having a therapeutic or preventive effect on neurological diseases, particularly dementia and the like.

A preferred aspect of the present invention is characterized in that the control means controls a time during which a gas having a predetermined oxygen concentration is supplied from the gas supply means to the supply target.

By using a control mechanism instead of human hands to control the timing of supplying gas, a highly accurate method of treating or preventing a neurological disease can be realized.

A preferred form of the present invention is characterized in that the control mechanism is configured to supply the high oxygen supply to the supply target for 10 minutes to 120 minutes after supplying the low oxygen supply to the supply target for 1 minute to 60 minutes. The mode controls the aforementioned gas supply unit.

By controlling the supply sequence and supply time of low oxygen and high oxygen as described above, it is possible to provide a highly effective method for treating or preventing neurological diseases.

A preferred aspect of the present invention is characterized in that the gas supply unit can supply a gas containing oxygen and nitrogen to the supply target, and the control mechanism controls the ratio of nitrogen in the supplied gas to control the gas from the gas supply unit. The oxygen concentration in the gas supplied to the aforementioned supply target.

By controlling the content ratio of nitrogen, the oxygen concentration of the supplied gas can be adjusted more easily.

A preferred aspect of the present invention is characterized by having an oxygen-nitrogen concentrator having the ability to separate air into oxygen and nitrogen, as an oxygen and nitrogen generation source supplied from the gas supply unit.

By using an oxygen-nitrogen concentrator, the oxygen and nitrogen contained in the gas can be easily generated.

A preferred aspect of the present invention is characterized in that the gas supply unit can control a gas containing oxygen and hydrogen to the supply target, and the control mechanism controls the ratio of the hydrogen from the gas supply unit to the gas supply unit. The oxygen concentration in the gas supplied by the aforementioned supply target.

By adopting this configuration, the occurrence of side effects in hypoxic breathing can be reduced, and the health-improving effect obtained by hydrogen inhalation is also expected.

A preferred aspect of the present invention is characterized by including a breathing hood for supplying gas to the supply target, a safety exhaust hood arranged to cover the outside of the breathing hood, and suction from the safety exhaust hood. Exhaust suction mechanism; the safety exhaust hood is configured to create a gap between the breathing mask and the face of the supply subject when the breathing mask is worn on the face of the supply subject; When the subject's face is supplied with gas to the supply subject, the hydrogen mixed gas leaking from the breathing mask is sucked together with the surrounding air from the gap between the air exhaust hood and the face, and is stirred and mixed with the air to Reduce the hydrogen concentration of the aforementioned hydrogen mixed gas, dilute it below the flammable explosive concentration, and safely exhaust it indoors or outdoors.

By setting it as such a form which reduces the hydrogen concentration of the said hydrogen mixed gas and performs exhaust by stirring and mixing with air, safety can be improved.

A preferred form of the present invention is characterized by having a pulse oximeter that senses percutaneous arterial oxygen saturation of a supply target; the control mechanism is connected to the pulse oximeter; and the control mechanism is provided to the supply target. In the supply of the low oxygen, when the percutaneous arterial oxygen saturation of the arterial blood flowing to the brain of the supply target as perceived by the pulse oximeter is lower than a predetermined value, the supply target is controlled to start supplying the high oxygen. The aforementioned gas supply unit.

By setting it in such a manner that it is linked to the pulse oximeter, it is possible to realize more effective and safe neurological disease treatment or prevention.

A preferred aspect of the present invention is characterized in that the gas supply unit is a pressurized gas supply device and includes a high-pressure chamber which is supplied with pressurized gas from the pressurized gas supply device, And can accommodate the aforementioned supply target.

With this configuration, it can be used in combination with hyperbaric oxygen therapy.

The present invention also relates to a medical system including the medical device described above, and a transcranial current stimulation device having an electrical stimulation unit for applying a transcranial electrical stimulation to the scalp of the supply target, or having a supply target to the supply target. Low-frequency treatment device for electrodes applying low-frequency current.

The medical system according to the present invention can be used in combination with transcranial direct current stimulation or low frequency therapy.

The invention also relates to a medical device, which is characterized by comprising a low oxygen chamber filled with low oxygen with an oxygen concentration of 18% or less, and a high oxygen chamber filled with high oxygen with a oxygen concentration of 21% or more.

According to the medical device of the present invention, an effective method for treating and preventing neurological diseases can be realized.

A preferred form of the present invention is characterized in that: it has a moving body for placing a person or an animal's supply target and moves; the moving system is automatically placed in the low-oxygen room, the high-oxygen room, and the outdoor as instructed by the control unit. The method of movement is controlled; the control unit moves the moving body to the high-oxygen chamber after a preset time has passed in the low-oxygen chamber, and moves to the high-oxygen chamber after the preset time has elapsed. Control the moving body by moving outdoors.

By adopting such a configuration, it is possible to provide a high-precision treatment and prevention method for neurological diseases to more patients.

According to the medical device, medical system and medical device of the present invention, effective treatment or prevention of neurological diseases, especially dementia and the like can be realized.

1‧‧‧Human body, head (users who use programmed regenerative medical breathing devices)

2‧‧‧ brain

3‧‧‧ common carotid artery

4‧‧‧ Reflective Pulse Oximeter (Wired or Wireless)

5‧‧‧ lung

6‧‧‧ High Flow Intubation

7‧‧‧ Suction tube for intubation

8‧‧‧ Respirator (closed type)

8a‧‧‧ Exhalation and inhalation confluence unit or exhalation and inhalation switching mechanism (can be assembled into an explosion-proof device when the hydrogen concentration is above 10%

9‧‧‧ Inhalation route

10‧‧‧ Exhalation, exhaust

11‧‧‧inhaled gas, inhaled gas (hydrogen, nitrogen, oxygen)

12‧‧‧ breath (including hydrogen)

13‧‧‧ Exhaled aspirator (extract air and exhaled air by stirring)

14‧‧‧Hydrogen supply unit (water electrolytic hydrogen generator)

15‧‧‧Oxygen and nitrogen supply section (air concentration and separation type)

16‧‧‧Exhaust (pipe or hose) for high concentration hydrogen mixed exhalation

17‧‧‧ Breathing aspirator (breathing aspirator) that mixes and releases indoor air with exhaled breath

18‧‧‧ oxygen and nitrogen supply (air concentration and separation type)

20‧‧‧ One of oxygen, nitrogen and hydrogen body type gas generating device (variable generation capacity type)

21‧‧‧Program control device

22‧‧‧Remote controller for setting of program control device (Remote controller for setting)

23‧‧‧Signal cable for remote controller and program control device

24‧‧‧ Supply gas temperature adjustment and humidifier (bubble type in water or hot water)

25‧‧‧ Hydrogen concentration sensor

26‧‧‧Air inlet

27‧‧‧Exhaust port for gas inside the integrated generator (gas exhaust port)

28‧‧‧High-flow intubation gas supply line

28a‧‧‧Venturi hood gas supply line

29‧‧‧ Reflective Pulse Oximeter Signal Cable

30‧‧‧Control cable for program control device and integrated gas generating device

31‧‧‧ One of the body-type gas generating devices with an exhalation recirculation function

32‧‧‧ Carbon dioxide adsorption department (Litholyme, etc.)

33‧‧‧closed type nose and mouth mask

34‧‧‧closed mask

35‧‧‧ Breathing and inhaling confluence unit

36‧‧‧O ₂ concentration meter and expiratory flow meter

37‧‧‧Gas Outflow Direction Switching Valve

38‧‧‧Wireless LAN (local area network) (WiFi) program control device

39‧‧‧Control cable for integrated gas generator

40‧‧‧Inspiratory volume sensor

42‧‧‧Electric wheelchair (automatic operation control type: charging type) evolution type professional pilot chair

43‧‧‧Automatically closed and closed door

44‧‧‧Using automatic opening and closing closed door

45‧‧‧ Closed entrance to the treatment room in hypoxic area

46‧‧‧ Closed contact path from hypoxic area treatment room to hyperoxic area treatment room

47‧‧‧closed exit passage from hyperoxic area treatment room

48‧‧‧ left side access of hyperoxic area treatment room

49‧‧‧ Central access to the hyperoxic zone treatment room

50‧‧‧ Right side access of hyperoxic area treatment room

51‧‧‧Closed structure treatment room, etc.

52‧‧‧Automatic van for moving out of electric wheelchair (automatic operation control)

53‧‧‧Gas supply system (environmental management system) for hypoxic area treatment rooms

54‧‧‧Gas supply system (environmental management system) for high oxygen area treatment room

55‧‧‧ Indoor Wireless LAN Antenna Unit

56‧‧‧User (seat)

60‧‧‧ Hypoxic Area Treatment Room

61‧‧‧High Oxygen Regional Treatment Room

FIG. 1 is a schematic diagram of a regenerative medical system using a breathing method in which the oxygen concentration is changed stepwise, and the inhaled oxygen concentration is controlled manually or programmatically to control reactive oxygen species (ROS). A schematic diagram of the production concentration.

FIG. 2 is an explanatory diagram of a regenerative medical system using a breathing hood that uses a breathing method that changes the oxygen concentration stepwise. Try to handle the exhaled breath mixed with high concentration of hydrogen safely.

FIG. 3 is an explanatory diagram of an air concentrating and separating type oxygen and nitrogen supplier as an oxygen and nitrogen supply mechanism. The existing oxygen concentrator is improved to achieve the object.

FIG. 4 is a diagram of an example of a regenerative medical system using a breathing method that changes the oxygen concentration stepwise, using a high-capacity cannula or a venturi mask (Example 1).

FIG. 5 is a diagram of an embodiment of a regenerative medical system using a breathing method in which the oxygen concentration is changed stepwise, and a breathing mask is used. The system is equipped with an exhalation and inspiratory flow meter for detecting the user's breathing volume, and an exhalation recirculation function can be added at the same time, which improves the flexibility of the system (Example 2).

FIG. 6 is a diagram showing an embodiment of a regenerative medical system using a high-pressure therapy device using a breathing method that changes the oxygen concentration stepwise (Example 3).

FIG. 7 is an explanatory diagram of an estimated action mechanism of a regenerative medical system using a breathing method in which the oxygen concentration is changed stepwise.

Fig. 8 is an explanatory diagram of a regenerative medical system using a breathing method in which the oxygen concentration is changed stepwise, and a partial hypoxic state of the brain is shown using a transcranial direct current stimulation method.

FIG. 9 is an explanatory diagram of the influence of the amount of mitochondrial energy produced by brain nerve cells on the state of neural activity.

FIG. 10 is an explanatory diagram of an example of blood flow, blood flow distribution, and oxygen consumption amount of each organ at rest.

FIG. 11 shows the experimental results using experimental animals (rats) on the temporal changes of active oxygen generation and glucose metabolism in the brain during hypoxia-reoxygenation. Excerpted from Basic Aging Research 35 (4); 17-26, 2011 (Physiological Function of Active Oxygen, Toru Sasaki, Tokyo Metropolitan Institute of Health and Longevity Medical Center).

FIG. 12 is a graph showing an increase in the production of active oxygen during the release of the need for hypoxia, and is a result of an experiment using an experimental animal (rat). Excerpted from Basic Aging Research 35 (4); 17-26, 2011 (Physiological Function of Active Oxygen, Toru Sasaki, Tokyo Metropolitan Institute of Health and Longevity Medical Center).

Figure 13 is an explanatory diagram of hyperactive oxygen generation during the release of supply hypoxia and demand hypoxia, extracted from Basic Aging Research 35 (4); 17-26, 2011 (Physiological Functions of Active Oxygen, Toru Sasaki, Tokyo Metropolitan Institute of Health and Longevity Medical Center).

Fig. 14 is an explanatory diagram of a generation model of active oxygen. Excerpted from Basic Aging Research 35 (4); 17-26, 2011 (Physiological Function of Active Oxygen, Toru Sasaki, Tokyo Metropolitan Institute of Health and Longevity Medical Center).

Figure 15 is a diagram of the ROS generation process and its removal system, excerpted from p411, Oxidative Stress Medicine (Diagnostic and Therapeutic Society).

FIG. 16 is a diagram of a cell cycle and a structure that regulates the cell cycle.

Figure 17 is a chart of the golden hour rule.

Figure 18 is a diagram of the molecular mechanism of HIF (hypoxia-inducible factor) activation caused by hypoxia. Excerpted from Biochemical, Vol. 84, No. 11 HIF-induced glucose and lipid metabolism in the liver.

Figure 19 is an explanatory diagram of the CO-sensing H2S information transmission path found as the structure of hypoxic vasodilation, extracted from living gas molecules related to the defense mechanism of the hypoxic state of the brain, and cerebral ischemia and other pathological conditions Development of Control Law, Keio University, Department of Medicine.

Figure 20 is an explanatory diagram of the role of IL-6 / IL-21 signals in pulmonary hypertension, excerpted from elucidating the pathogenesis of pulmonary hypertension, Osaka University Graduate School of Medicine Department of Internal Medicine Lecture (Circular Organ Medicine) Ryo Nakaoka and assistant, other notes.

Fig. 21 is a limit diagram showing telomere length and mitochondrial activity for the longest life.

FIG. 22 is a regenerative medical system using a breathing method in which the oxygen concentration is changed stepwise using the preventive exercise for dementia (Example 4).

FIG. 23 is a regenerative medical system using a fully automatic-controlled mobile electric wheelchair system using a breathing method that changes the oxygen concentration stepwise (Example 5).

Hereinafter, embodiments of the present invention will be described in detail. In addition, in this specification, treatment or prevention using the medical device, medical system, or medical device of the present invention may be referred to as a regenerative medical system.

As described above, when symptoms such as neurological diseases, especially dementia, occur, the mitochondria that accompany the nerve cells in the brain must be low and insufficiency. Therefore, if the mitochondrial function of brain nerve cells is improved, symptoms can be restored.

The mitochondrial electron transfer system generally accounts for more than 90% of the cell's oxygen consumption, and it can be said that 1% to 5% of them are converted into reactive oxygen species. The range is 30 μM. It can be said that the amount of active oxygen produced in the nerve cell is different in each cell.

It is possible to change the amount of active oxygen generated in the living body, particularly at least a part of the brain nerve cells due to the change in the oxygen concentration of the breath, that is, the concentration converted to H ₂ O ₂ (hydrogen peroxide), By using this breathing machine, the active oxygen species concentration in the brain nerve cells, here the hydrogen peroxide concentration is set to be 2.4 times the initial value during the transition of the user's breathing gas from low oxygen to high oxygen. concentration.

Fig. 1 is a method for solving the problem, wearing a high-flow type intubation or a breathing mask as a breathing apparatus, and the user (patient) performs gas respiration in which the ratio of oxygen, hydrogen, and nitrogen is controlled. The system is a device that separates oxygen and nitrogen in the air and outputs oxygen and nitrogen at any ratio, a device that electrolyzes water and takes out hydrogen and oxygen separately, and a manual operation switch or program control that controls the components of the device in sequence Device.

FIG. 11 shows experimental data using rats, which shows a situation in which the concentration of active oxygen species generated in a cell is changed by switching the breathing gas of a target animal from hypoxia to reoxygenation (hypoxia) according to a program. Fig. 12 shows experimental data using rats in the same manner, showing that when exercise is hyperactive and when resting, it is called needy hypoxia and when it is released. Even when the exercise is released by a program, it is the same as when breathing. Similarly, the concentration of reactive oxygen species produced in a cell varies. In either case, it can be seen that the increase in active oxygen reaches a factor of 2.4 before and after the change. Each situation is illustrated easily in FIG.13 and FIG.14.

FIG. 15 shows a state in which a superoxide produced by oxygen in a cell is changed to another active oxygen species. Most conversions are generally considered to be relatively stable hydrogen peroxide. In humans, there are antioxidant substances as shown in Table 1. There are various antioxidants such as thioredoxin, glutathione, SOD (superoxide disrmutase), and vitamin C, which play a role in reducing the concentration of reactive oxygen species. Table 2 shows the active oxygen species and the antioxidants from which the active oxygen species were removed. Table 3 shows examples of the concentration of antioxidant metabolites in human serum and the concentration in liver tissue. In this way, the concentration of active oxygen species in vivo and in the tissue gradually changes through the time series of the production of active oxygen species and the elimination effect of antioxidant substances in the body and the balance of parts (parts) in the body.

Using the device of FIG. 1, the user can initially perform hypoxic breathing according to the program setting, and perform normal oxygen or hyperoxia breathing at a set time after the set time according to the timing setting. There are precautions at this time. Figure 17 shows the effect of cardiac arrest or respiratory arrest on life support in the Golden Hour Principle as a function of time. Table 5 shows the effects on oxygen concentration and human body. With reference to these materials, the oxygen concentration and action time in the low-oxygen area are determined by the safety range, and the safety range is determined by referring to Table 1, Table 2, Table 3, Figure 11, Figure 12, Figure 13, Figure 14, and Figure 17. Oxygen concentration and action time in the hyperoxic zone. In addition, it is necessary to avoid ingestion of vitamin C and the like having an antioxidant effect on hydrogen peroxide before and after treatment.

When using a regenerative medical system that uses a breathing method that changes the oxygen concentration stepwise, it is not an absolute condition, but it is desirable that a specialist in the respiratory department first use a spirometer to receive a pulmonary function test and disease. Status check. In order to use the breathing apparatus, the breathing pattern of the user and the ventilation characteristics of the alveoli become problems. Table 6 shows the breath volume and alveolar ventilation volume per time. In the case of shallow breathing, the timed alveolar ventilation decreases, and it takes longer to achieve a low-oxygen area or a high-oxygen area that is effective for a living body. In this case, it may be difficult to obtain an effective living response for the same timing setting, for example, the area of regeneration of brain cells is narrowed. As an example of lung function, in terms of total exhaust volume = vital capacity + residual capacity, adult men become 5000L to 6500L, and adult women become 3500L to 5000L. This value decreases with age. Therefore, in this regenerative medical system using a breathing method that changes the oxygen concentration stepwise, deep and slow breathing is recommended.

Regarding the initial setting of a regenerative medical system that uses a breathing method that changes the oxygen concentration stepwise, the sequence control is used. The hypoxic zone is set at intervals of 20 seconds from the first 1 minute to 10 minutes and within 10 minutes. It can be set every 1 minute from 60 minutes. The oxygen concentration is below 18%, and theoretically it can be 0%. However, because the risk is high and no advantage is found, the minimum oxygen concentration is assumed to be about 5%.

Regarding the effect of hydrogen, the purpose was originally to eliminate the hydroxyl radicals of the active oxygen species. However, in the present invention, the purpose is to suppress the arousal of inflammatory interleukins. The concentration of H ₂ and hydrogen in the suction gas is based on About 4% is standard. If necessary, the use of 95% to 90% hydrogen concentration and 5% to 10% oxygen concentration can also be achieved in a short time by adding a special disaster prevention device. The oxygen concentration is set to 21% or more in the use of the high-oxygen region in the latter part of the sequence, but when the upper limit is normal pressure, the convenience is also considered, and about 60% is assumed.

The transport of oxygen in the blood stream is responsible for hemoglobin. Even if the oxygen concentration is increased, the oxygen transport capacity to living tissues is only increased by the dissolved oxygen based on the partial pressure of oxygen in the alveoli, but the situation is different from the perspective of regenerative medicine. . This is why the oxygen concentration is set to 21% or more.

FIG. 7 is an explanatory diagram of an estimated action mechanism of a regenerative medical system using a program-controlled breathing method. The purpose of setting the latter part of the sequence as a hyperoxia region is to further expand the regeneration region of brain cells. For the hydrogen peroxide produced in the area of brain cells, the antioxidant power of the living body works by eliminating or reducing the hydrogen peroxide. Moreover, the function of mitochondria is different for each cell in a cell. Therefore, the structure of the regenerative medicine is in the function of the system. The concentration of H ₂ O ₂ hydrogen peroxide produced in the cells must be set to 2.4 times in a suitable time in the operation of the system, if it is 2.1 times or 2.2 times. Does not cause mitochondrial genome initialization. Therefore, in order to make 2.4 times the active oxygen concentration appear in a wider area of the cerebral nerve cells, the oxygen concentration that the user sucks is increased.

The respiratory system in the hyperoxic zone requires at least 10 minutes, and is preferably performed for 30 minutes to 60 minutes. The reason is that it is considered that the oxidation phenomenon and the (reduction) anti-oxidation phenomenon are continuously performed due to blood flow or various reactions in a living body, and the value of the active oxygen concentration fluctuates. In addition, as the end of breathing for stabilization of excessive responses (side effects, allergic reactions) in the living body after this step, it is preferable to be in the range of 20 minutes to 60 minutes with an oxygen concentration of about 21% and a hydrogen concentration of 5% to 10%. Suction breathing.

In Figure 7, the brain has selective fragility, and it has also been determined that the sites of selective fragility are susceptible to oxidative stress. This regenerative medical system is thought to act early on this selective vulnerability site. Moreover, it is thought that the treatment of the regenerative medical system including the hypoxic region shows not only the ischemic tolerance of the brain but also the hypoxic tolerance of the brain.

On the other hand, in "Initial Mechanism of Mitochondrial Genome" in the Institute of Physics and Chemistry, Fig. 16 shows the cell cycle and the structure that adjusts the cell cycle, which can be said to be performed in accordance with such a cell cycle (division M). Initialization of the mitochondrial genome. Table 4 is a table showing the renewal rate and metabolism of living cells. The rapidly renewing part of the brain becomes 40% in one month. By continuously performing the treatment with the present invention at a daily or twice a day schedule, at least a part of the neurons with mitochondria in the brain can be regenerated into A neuron with normal function of mitochondria. In other parts of the living body, depending on the target site, the cell tissue or cell cycle is different, and the state of arterial blood is different. Therefore, it is necessary to comply with the settings or designs of each site.

The regenerative medical system using a breathing method that changes the oxygen concentration stepwise according to the present invention can be called a hidden in vivo constant (living constant system) or a cell regeneration system originally provided in the human body. Therefore, it is a system that is relatively less prone to side effects and the like. In principle, it is beneficial for the treatment and prevention of all diseases caused by mitochondrial dysfunction or insufficiency, and, similarly, for the treatment of diseases caused by the production of reactive oxygen species caused by mitochondrial dysfunction. And prevention is useful.

Table 7 compares the current time points of neurological diseases such as dementia with other treatment methods. In the strategy of each pharmaceutical company for the treatment of drugs, the response to inflammatory substances, amyloid beta, or substances called Tau proteins accumulated in the brain with dementia is a solution, but even if these substances are processed ( (Reduction) and no significant improvement in brain function was seen. On the other hand, if treatment with a regenerative medical system using a breathing method that changes the oxygen concentration stepwise is expected, improvement of brain function is expected (this is because ATP (Adenosine-Triphosphate, adenosine triphosphate) is improved due to the improvement of mitochondrial function. ) The function is increased, and the energy available for neural activity is increased.) However, in the state where amyloid β or Tau protein has been increased and is present inside the brain, does the treatment method of the present invention reduce these substances? The system is unknown. If Tau protein is increased, there is a concern that the immune function may be increased or the oxidative stress may increase. In this regard, the strategies of each pharmaceutical company and the regenerative medical system using a breathing method that changes the oxygen concentration stepwise may have a common interest relationship.

Regarding other regenerative medicines, regarding SB623 (Sanbio) and MA-5 (Tohoku University), the SB623 is administered with a regenerative cell medicine in the brain by performing surgery. The MA-5 system can be said to improve the function of mitochondria, but Either treatment method is different in terms of administration of the therapeutic substance to the living body, and is a very laborious treatment method. The method of the present invention only changes the existing breathing method, and has a simple structure and relatively simple application.

Moreover, multi-lineage differentiated persistent stress cells, iPS artificial pluripotent stem cells, and multi-lineage persistently stressed cells are also technologies expected for neurological diseases in the future, but the question is whether they can be set inexpensively in terms of price.

Various exercise therapies for the prevention of dementia have aspects that are compatible with the action mechanism of the present invention. Brain nerve cells also generate active oxygen through exercise. Initialization of the mitochondrial genome is caused by a small number of nerve cells. Functional improvement.

Regarding the evidence, there are several rumors that if vitamin C is taken before exercise, there is no effect of improving physical function by exercise. By using the theory of the present invention to supplement the ambiguous part of the action mechanism of exercise therapy, it is considered that the efficiency of exercise therapy is greatly improved.

Furthermore, as shown in Tables 7 and 8, a regenerative medical system using a breathing method that changes the oxygen concentration stepwise is shown in Tables 7 and 8. By using a hypoxic breathing zone, the vasodilation effect of FIG. 19 is used to regenerate capillaries. Various effects caused by the activation of HIF (hypoxia-inducing factor) shown in FIG. 18, promotion of myocardial division, regeneration of myocardium, and inhibition of ROS production, and further the use of hypoxia in FIG. 20 by the addition of hydrogen Inhibition of pulmonary hypertension caused by bloodemia, inhibition of inflammatory cytokines and gene expression of hormones, and there are TNF (Tumor Necrosis Factor; tumor necrosis factor) -α, interleukin IL-1 β, The expression of IL-6, IL-10, IL-12, CCL2, interferon (INF) -γ, intercellular adhesion molecule 1 (ICAM-1), PGE1, PGE2, etc. was reduced. Furthermore, since the regenerative medical system using a breathing method that changes the oxygen concentration stepwise as the target age of treatment uses the cell cycle, it is considered that the limit of this regenerative medical system can be reached to the Herflick limit of FIG. 21 (Hayflick limit), treatment to about 120 years old.

Furthermore, a regenerative medical system using a breathing method that changes the oxygen concentration stepwise can also be used in conjunction with the brain-based transcranial direct current stimulation therapy shown in Figure 8, or combined with the low-output extracorporeal shock wave therapy of the heart, or with the hands and feet. The combination of blood drive therapy, etc., makes part of the body appear to require primitive hypoxia, or combined with high pressure oxygen therapy such as hydrogen peroxide drip therapy. In addition, therapies that apply a load to a part of the living body by a suitable method also include massage or acupressure, low-frequency therapy devices, and thermotherapy. Fig. 10 is an example of blood flow, blood distribution, and oxygen consumption of various organs when the human body is quiet. Regarding the initialization of the mitochondrial genome for cells other than the brain, if the changes in the oxygen concentration of the alveoli of the breath are calculated by the blood flow prediction of each blood vessel in each organ or region, It can also be applied to a part other than the brain by performing a state caused by a change in active oxygen. Therefore, a regenerative medical system using a breathing method that changes the oxygen concentration stepwise is not limited to the prevention and treatment of dementia, and is relatively easy to use for relatively safe regeneration of mitochondrial function in human cells. Contributes to regenerative medicine that is cheaper to achieve.

When the treatment of the regenerative medical system is performed for a certain period of time, the function of mitochondria of nerve cells in the brain is improved, and more energy can be used in brain nerve cells than before. This change is manifested in neural activity as improvement in cognitive ability or improvement in memory. In FIG. 9, the case where the energy of the nerve cells is small is set to A, the case of the standard energy state is set to B, and the higher state is set to C. In the speculation of clinical experiments, when the brain is in a low-energy state A, the brain nerve cells can be used as consciousness and cognitive activity per unit time, so there is little level or frequency of cognition, and it is impossible to detect the surrounding changes. The accuracy and awareness of the surrounding events are reduced. Also, the standard's level of recognition is B, so it is impossible to perceive the speed of surrounding changes and become at a loss. Even if one wants to express something, it is difficult because nerves have insufficient energy for thinking. On the other hand, if the system is used for treatment within a sufficient period of time to improve the level of energy expression of brain nerve cells, it will become a C-like state, and the energy available per unit time will increase as a nerve activity. If it is in this state, the accuracy and the number of times of recognition of the surrounding events will be greatly improved, so that the surrounding events can be clearly grasped. In the state of C, the nerve cells of the brain can also perform multiple tasks in neural activities. If the person in the state of A becomes C, the number of consciousness and recognition per unit time increases, so if it is to the surrounding and middle spirit, it can be slowly Perceive the movement of things. In figurative terms, this is the difference between looking at a 10-frame leap second image and looking at a 30-frame leap second image. Although this is a speculation in clinical experiments, it is believed that although there are individual differences, patients with dementia and the like can expect exceptional improvements in cognitive function and memory using this system.

In vivo distribution of antioxidants (based on antioxidants)

Although human beings have the ability to regenerate as described above, they have their limits. Needless to say, even a finger can't reproduce.

Self-fragmentation can regenerate worms in the entire body and people who cannot regenerate even one finger. The key to grasping this difference is a cell called a "stem cell."

◆ Dosing limit of high concentration oxygen

High concentrations of oxygen cause harm to the human body. The concentration of oxygen that is mixed with the surrounding air and actually enters the airway is called the inhaled oxygen concentration. For example, even if 100% oxygen is inhaled from a gas cylinder, if the flow rate of oxygen is low, oxygen is inhaled together with the surrounding air, so the oxygen concentration in the airway decreases. In the medical field, the investment limits as shown in the table below are recognized.

Known as type II respiratory failure, patients who are sick due to inadequate ventilation in the lungs and whose carbon dioxide concentration in the blood is high may inhale CO ₂ anesthesia if they inhale high concentrations of oxygen.

The above table shows the difference between time-of-day ventilation and time-of-day alveolar ventilation caused by breathing patterns. If the volume of one ventilation in the case of normal breathing is set to 500 mL, the volume of alveolar ventilation obtained by subtracting the amount of dead space from this is 350 mL.

A mode in which a gas in which nitrogen and hydrogen are mixed in addition to oxygen is supplied to a supply target will be described.

In this embodiment, an air condensing type including a cannula (high flow type) for breathing oxygen, nitrogen, and hydrogen, a breathing mask, or a breathing mask such as a breathing mask, and a nitrogen supply mechanism and an oxygen supply mechanism Oxygen and nitrogen supply. Furthermore, it is equipped with a MEA (Membrane Electrode Assembly; membrane electrode assembly) water electrolysis type hydrogen generator or hydrogen supplier as a hydrogen supply mechanism, and also supplies about 50% of the generated hydrogen gas oxygen.

A cover or the like that transports these to a user's mouth using a tube or hose. In addition, the program control device and its controller that control the supply and timing of oxygen, nitrogen, and hydrogen are used, and the intubation is used for breathing, and when the concentration of hydrogen supply exceeds 10%, the intubation form is used. Safety exhaust hood, from which the surrounding air is mixed with the exhaled air and recovered, and the hydrogen concentration of the mixed exhaled air is discharged to the surroundings below 4%. It is connected with a variable electric exhalation aspirator releaser and connected to When the hose or tube is used for exhalation according to the situation, and when adjusting gas (oxygen, hydrogen, etc.) is added to the exhalation, a carbon dioxide adsorption section (absorption section) is provided on the extension line of the exhalation line.

Further, if necessary, an inspiratory meter and an exhalation flow meter are provided in each line, and an outflow direction switching valve of exhaled gas is provided at a necessary portion. For safety, it consists of a hydrogen concentration sensor for monitoring so that the indoor hydrogen concentration does not exceed 4%. Generally, the supply part of the breathing gas is made in a package.

What is important is the content of the program. When wearing a breathing apparatus for treatment, the user must start from a low-oxygen area with an oxygen concentration of less than 18%, start with a condition that the patient can adapt, and then manually pass the appropriate time for each patient. Operate or automatically change the breath to a hyperoxic area with an oxygen concentration of 21% or more. Thereafter, the intracellular concentration of hydrogen peroxide with active oxygen species stayed around 2.4 times the initial concentration in the high-oxygen region for a suitable time to stabilize the respiration, and then gradually reduced the oxygen concentration to 21%, so that the intracellular concentration of The concentration of active oxygen species was reduced to near the initial value, and the stable breathing was completed for the purpose of ending. These series of actions can be controlled automatically by manual operation or program control device. The setting content of each user can be input to the program control device in advance by setting the remote control.

In addition, when a reflective pulse oximeter is mounted (attached) to the common carotid artery and a part of the process is controlled by the value of the percutaneous arterial oxygen saturation, (to prevent excessive hypoxic state of cerebral arterial blood) ) The SpO2 signal of this common carotid artery is taken into the program control device and can be processed further. (Remote setting is required in advance.) By greatly remodeling the existing breathing machine in such a way, and then adopting a special breathing method, it can also be called the regeneration of mitochondria of the cell, thereby achieving the perfection of the function and achieving a very high effect. A regenerative medical system that uses a breathing method that changes the oxygen concentration stepwise.

A particularly preferred embodiment of the invention described above is as follows.

<1> A medical system for increasing active oxygen concentration in brain nerve cells, comprising a gas supply unit capable of supplying at least a low oxygen concentration of 21% or less to a human or animal supply target and a low oxygen concentration of 21% The above high oxygen; and a control unit that controls the oxygen concentration of the gas supplied from the gas supply unit to the supply target; the control unit controls the time when the gas with a predetermined oxygen concentration is supplied from the gas supply unit to the supply target; the control unit The above-mentioned gas supply unit is controlled by first supplying the low oxygen to the supply target, then supplying the high oxygen to the supply target for 10 minutes, and then ending the gas supply.

<2> The medical system for increasing the active oxygen concentration in brain nerve cells as described in <1>, characterized in that the control mechanism controls the gas supply unit by: After the supply of the low oxygen, the supply of the high oxygen is performed on the supply target for more than 10 minutes, and then the supply of the gas is ended.

<3> A medical system for increasing the active oxygen concentration in brain nerve cells, which is characterized by a gas supply unit capable of supplying at least a low oxygen concentration of 21% or less to a human or animal supply target and a low oxygen concentration of 21% The above high oxygen; and a control mechanism that controls the oxygen concentration of the gas supplied from the gas supply unit to the supply target; the control mechanism controls the gas supply unit in the following manner: after the supply of the low oxygen to the supply target, The supply target is supplied with the high oxygen for more than 10 minutes, and then the supply of the low oxygen is not performed.

<4> The medical system for increasing the active oxygen concentration in a brain nerve cell according to <3>, wherein the control means controls the gas supply unit in the following manner: First, the gas supply is performed for at least one minute. After the supply of the low oxygen, the supply of the high oxygen is performed for more than 10 minutes on the supply target, and then the supply of the low oxygen is not performed.

<5> The medical system for increasing active oxygen concentration in a brain nerve cell according to any one of <1> to <4>, wherein the gas supply unit can supply the supply target with oxygen and nitrogen The control means controls the oxygen concentration in the gas supplied from the gas supply unit to the supply target by controlling the ratio of nitrogen in the supplied gas.

<6> The medical system for increasing the active oxygen concentration in a brain nerve cell according to any one of <1> to <5>, characterized in that it is provided with an oxygen-nitrogen concentrator as the gas supply unit The supply source of oxygen and nitrogen has the ability to separate air into oxygen and nitrogen.

<7> The medical system for increasing active oxygen concentration in brain nerve cells according to any one of <1> to <6>, wherein the gas supply unit can supply the supply target with oxygen and hydrogen. The above-mentioned control mechanism controls the oxygen concentration in the gas supplied from the gas supply unit to the supply target by controlling the ratio of hydrogen in the supplied gas.

<8> The medical system for increasing the active oxygen concentration in a brain nerve cell according to <7>, comprising a breathing mask for supplying gas to the aforementioned supply target, and a method of covering the outside of the breathing mask A safety exhaust hood configured and a suction mechanism for sucking exhaust gas from the safety exhaust hood; the safety exhaust hood is used when the breathing hood is worn on the face of the supply target, A gap is formed between the face and the surface of the face; when the breathing mask is worn on the face of the supply target and gas is supplied to the supply target, a hydrogen mixed gas leaking from the breathing mask is passed from the gap between the safety exhaust cover and the face Suction with the surrounding air, reduce the hydrogen concentration of the aforementioned hydrogen mixed gas by mixing with the air, dilute it to below the flammable explosive concentration, and safely exhaust it indoors or outdoors.

<9> The medical system for increasing the active oxygen concentration in a brain nerve cell according to any one of <1> to <8>, characterized in that it has a pulse that senses percutaneous arterial oxygen saturation of a subject to be supplied. The oximeter; the control means is connected to the pulse oximeter; the control means controls the gas supply unit in the following way: in the supply of the low oxygen to the supply target, the supply target perceived by the pulse oximeter When the percutaneous arterial blood oxygen saturation is lower than a predetermined value, the supply target starts to supply the aforementioned high oxygen.

<10> The medical system for increasing active oxygen concentration in brain nerve cells according to any one of <1> to <9>, wherein the gas supply unit includes a pressurized gas supply device, and the medical treatment The system includes a high-pressure chamber, which is supplied with pressurized gas from the pressurized air supply device and can accommodate the supply target.

<11> The medical system for increasing active oxygen concentration in a brain nerve cell according to any one of <1> to <10>, comprising a transcranial current stimulation device or a low-frequency treatment device, and the aforementioned transcranial The current stimulation device includes an electrical stimulation unit that applies transcranial electrical stimulation to the scalp of the supply target, and the low-frequency treatment device includes an electrode that applies a low-frequency current to the supply target.

<12> An active oxygen concentration increasing agent in brain nerve cells, which is composed of low oxygen with an oxygen concentration of 18% or less and high oxygen with an oxygen concentration of 21% or more. It is characterized by being used in the following manner: After oxygen is supplied to a supply target of a person or an animal, the high oxygen is supplied to the supply target for 10 minutes or more, and then the supply target is not supplied.

<13> An active oxygen concentration increasing agent in brain nerve cells, which is composed of low oxygen with an oxygen concentration of 18% or less and high oxygen with an oxygen concentration of 21% or more. It is characterized by being used in the following way: first the aforementioned low oxygen After being supplied to a supply target of a person or an animal, the high oxygen is supplied to the supply target for 10 minutes or more, and then the low oxygen is not supplied to the supply target.

<14> The agent for increasing active oxygen concentration in a cerebral nerve cell according to <12> or <13>, which is used for treating a neurological disease.

<15> A medical system characterized by having a low-oxygen chamber filled with low oxygen with an oxygen concentration below 18% and a high-oxygen chamber filled with high oxygen with a oxygen concentration above 21%; the aforementioned medical system is provided with A mobile body that is placed and supplied by a person or an animal; the mobile body is controlled by the control unit to automatically move in the low oxygen room, the high oxygen room, and the outdoor; the control unit is based on the mobile body After a preset time has passed inside the hypoxic chamber, it moves to the hyperoxic chamber, and after more than 10 minutes have passed inside the hypoxic chamber, the moving body is controlled to move outdoors.

<16> A method for increasing active oxygen concentration in brain nerve cells, which is characterized in that at least a low oxygen concentration of 18% or less is provided to a human or animal subject, and then an oxygen concentration of 21% or more is provided for more than 10 minutes High oxygen, then the aforementioned low oxygen and the aforementioned high oxygen supply are not performed.

<17> A method for increasing active oxygen concentration in brain nerve cells, which is characterized in that a human or animal subject is supplied with at least a low oxygen concentration of less than 18%, and then an oxygen concentration of 21% or more for more than 10 minutes High oxygen, then the aforementioned low oxygen supply is not performed.

<18> A method for increasing active oxygen concentration in brain nerve cells, which is characterized in that a human or animal supply subject first inhales at least a low oxygen concentration of less than 18%, and then inhales an oxygen concentration higher than the atmosphere for more than 10 minutes High oxygen of the gas, and then do not inhale the aforementioned low oxygen and the aforementioned high oxygen.

<19> The use of the aforementioned low oxygen and the aforementioned high oxygen as an active oxygen concentration increasing agent in brain nerve cells, which is characterized in that a low oxygen with an oxygen concentration of at least 18% is supplied to a human or animal subject, and then After supplying high oxygen with an oxygen concentration of 21% or more for 10 minutes or more, the aforementioned low oxygen and the aforementioned high oxygen are not supplied.

<20> The use of the aforementioned low oxygen and the aforementioned high oxygen as an active oxygen concentration increasing agent in a brain nerve cell, characterized in that a human or animal subject is supplied with at least a low oxygen concentration of at least 18%, and then High oxygen with a oxygen concentration of 21% or more is relayed for more than 10 minutes, and then the aforementioned low oxygen supply is not performed.

<21> The use of the aforementioned low oxygen and the aforementioned high oxygen for producing an active oxygen concentration increasing agent in a brain nerve cell, characterized in that a low oxygen with an oxygen concentration of at least 18% is first supplied to a human or animal subject Then, supply high oxygen with an oxygen concentration of 21% or more for more than 10 minutes, and then do not perform the aforementioned low oxygen and the aforementioned high oxygen supply.

<22> The use of the aforementioned low oxygen and the aforementioned high oxygen for producing an active oxygen concentration increasing agent in brain nerve cells, characterized in that a human or animal subject is first supplied with low oxygen with an oxygen concentration of at least 18% Then, a high oxygen with an oxygen concentration of 21% or more for more than 10 minutes is supplied, and then the aforementioned low oxygen supply is not performed.

[Example]

<Example 1>

FIG. 4 is an explanatory diagram of the first embodiment of the present invention. 1 indicates the user's head, and 2 indicates brain cells. 20 is a supply unit of oxygen, nitrogen, and hydrogen, and is an integrated gas generator. An air-concentrated separation type oxygen and nitrogen supply unit that uses internally generated water (distilled water) to generate hydrogen and oxygen by electrolysis and uses the MEA electrolysis unit for water electrolysis to separate and extract oxygen and nitrogen from air is concentrated. One packet, integrated use.

First, when using the device, the user receives a diagnosis from a specialist in the respiratory department and confirms that there is no particular obstacle to the device. In order to control the operation of the electrolytic hydrogen and oxygen generating part and the air concentrating and separating oxygen and nitrogen supply part inside the oxygen, nitrogen, and hydrogen supply unit 20, a program control device 21 is provided to control the on and off of the machine and generate output. It is the setting remote controller 22 that sets the control content of the program control device 21. The setting remote controller 22 is also used for manual operation. Regarding the setting contents of the program control device 21, in order to create a low-oxygen breathing region with an oxygen concentration of 18% or less, nitrogen is mixed with a small amount (several percent) of oxygen, and the supply amount (generation amount) per minute with hydrogen is set and operated. Setting of time. As the amount of nitrogen-hydrogen mixed gas increases, the oxygen concentration of the user's breathing decreases. The user mixes this trace amount of nitrogen-hydrogen mixed gas with the air around the hood and sucks it. Therefore, the relationship between the gas supply per minute from the device and the time-sharing alveolar ventilation caused by breathing is performed. Breathing brought by low oxygen concentration.

If the amount of alveolar ventilation increases in time, the amount of air mixed into the air surrounding the mask will increase correspondingly, and the oxygen concentration will be closer to the concentration of oxygen in the air. Therefore, paying attention to this point prompts the user to ensure the breathing volume.

In addition to the above methods, the concentration of oxygen to be sucked may be fixed only by the supply gas from the body gas generating device 20, which is one of oxygen, nitrogen, and hydrogen, which is not related to the amount of timed alveolar ventilation. It is sufficient to supply a sufficient amount of the gas mixed with the required oxygen concentration so that the air surrounding the hood is not mixed, but it will increase the burden on the device during operation.

Exhaust safety hoods are used when the hydrogen concentration in the gas that the user is pumping exceeds 10%. Within this range, the flow (airflow) (small blower, etc.) of the indoor air of the user is produced. ) And thereby ensure safety. (Although the general safety concept of hydrogen is set to exceed 4%, in actual experiments, if the hydrogen concentration is released from the cover, it will be mixed with the surrounding air and rapidly stirred to reduce the safety, so it is set as When the hydrogen concentration exceeds 10%) When the hydrogen concentration of the pumped gas exceeds 10%, the electric-powered exhalation stirring release device 17 of the exhalation stirring release device 17 makes the hydrogen concentration less than 4% and releases Go indoors, etc. The exhaled agitation releaser 17 includes a hydrogen sensor inside, and if the concentration of aspiration hydrogen exceeds 4%, it will automatically increase the release of aspiration in multiple stages to maintain the hydrogen concentration of the released gas at a safe concentration. The air used in the body gas generating device 20, which is one of oxygen, nitrogen, and hydrogen, is taken in from the air inlet 26, and unnecessary oxygen, nitrogen, and hydrogen are released from the gas outlet 27 to the outside of the machine. In addition, there is a hydrogen concentration sensor 25 for detecting the hydrogen concentration in the indoor space of the work space. If the hydrogen concentration outside the machine exceeds 4%, an alarm is output, and the system is incorporated into the interface to automatically stop the operation of the system. The temperature adjustment and humidifier 24 of the supplied gas is used to adjust the temperature and humidity of the gas sucked by the user, so that the gas sucked by the user foams in water or hot water to achieve the purpose. The temperature of the pumped gas is ideally about body temperature. Depending on the ambient temperature (indoor temperature), there is no problem with a low temperature. It is recommended that the humidity be slightly lower than the saturated steam.

In general, an intubation system using a nostril is suitable for an amount of gas of about 6 L per minute, but the present invention is applicable to an intubation in which the internal cross-sectional area is approximately doubled and the allowable range is set to about 10 L per minute. . The operation of the system is based on the multi-stage setting of the timer that passes over time, the on-off and output control of each element of the body gas generating device 20, which is one of oxygen, nitrogen, and hydrogen, and the control of the internal switching valve by the system instruction To achieve this, the reflective pulse oximeter 4 is worn on the common carotid artery, and the percutaneous arterial oxygen saturation value of the user is additionally controlled, which can be set by time or the percutaneous arterial oxygen saturation value. Either of the earlier signals goes to the next trip. This is to ensure the safety of the user, so that the oxygen saturation of the arterial blood does not violate the envisioned and is too low a safe treatment. The wearing (attachment) of the pulse oximeter to the common carotid arteries cannot be performed by the user himself, and therefore by a medical practitioner. Pulse oximeters, which are measured at the fingertips, are only used during quiet times, and are not suitable for the content of the present invention that changes all the time. By measuring the total carotid artery, the percutaneous arteries can be monitored for blood flow to the brain. Changes in blood oxygen saturation. This method is not required every time it is used, but it is beneficial to grasp the tendency in the first few times or so.

Explain the actual use situation, the user wears the cannula to the nostril. Then, the medical practitioner performs the setting of the remote controller 22 for setting. In actual treatment, in order to roughly grasp the health status of the user, first set the body gas generating device 20, which is one of oxygen, nitrogen, and hydrogen, to a standby state. Then, the air is blown to the nostril for about 3 minutes, slowly from about 2L per minute to about 10L per minute, and a preliminary inspection of the adaptive judgment of the user during intubation use is performed. At this point in time, a simple decision is made as to whether subsequent treatment can be performed. If there is no problem, the initial setting of the medical practitioner can be performed by manual operation or by program control. In the initial setting of the hypoxic zone, set the oxygen concentration to 18% to 14%, and the time starts from 2 minutes. (Select 1 minute when the oxygen concentration is set to 14% or less.) This selection is determined in consideration of the user's tolerance. Then it is set as a high oxygen area, and the user is allowed to suck a mixed gas of about 3L to 5L of oxygen and hydrogen of about 800cc per minute by using a sleeve. Consider this level for the first time. This level did not reach the therapeutic effect.

It is performed once to three times a day (morning, middle, and evening), and it is preferably performed once a day in the case of a heavy-load treatment. Prolong the time of the hypoxic area each time, and gradually reduce the oxygen concentration. The oxygen concentration in the hypoxic zone is from about 5% minimum (1 minute to 3 minutes: calculated based on my hypoxia tolerance) to SPO2 = 80 to 85 and 5 seconds to 15 seconds to end the hypoxic breathing , Immediately change to reoxygenation or hyperoxia area.

The maximum travel time in the hypoxic area is 60 minutes, and the minimum travel time in the high oxygen area is more than 30 minutes, and 50 minutes is recommended. The shorter the hyperoxic zone, the less the treatment effect, and the longer the treatment effect, the higher the treatment effect, but if it exceeds 120 minutes, there is not much difference.

<Example 2>

FIG. 5 is an explanatory diagram of a second embodiment of the present invention. Regarding the method of treatment, there is no change compared to Example 1, but the mechanics and system of the hardware are complicated. The main difference is that all the therapeutic gas pumped by the user is supplied from the integrated gas generator 31 provided with an exhalation recirculation function. Therefore, the used breathing mask becomes a closed type mask. Recirculate the exhaled breath, remove the oxygen dioxide in the exhaled breath with the 32 adsorbent, add the necessary ingredients in this step to adjust it for suction, or when there is no need for recirculation, It is safely released to the outside by the operation of the gas outflow direction switching valve of 37.

The system of the present invention can also be used in an artificial respiratory system, but what is shown in the present invention is only valid for the user's spontaneous breathing treatment. Therefore, it is necessary for me to promote breathing with high time-alveolar ventilation. The decrease in alveolar arousal efficiency caused by breathing means that the response speed in vivo in this treatment is slow, and the waveform of the characteristic curve of time and active oxygen generation Changes are slower and may lead to a reduction in the effectiveness of the treatment. Therefore, a sensor 36 is provided that is used to immediately know the expiratory volume of the user's current breathing during the treatment. The high-flow-type intubation gas supply line 28 includes a check valve, and the inspiratory flow meter 40 includes a hydrogen and oxygen concentration sensor.

If the flow rate difference between the flow rate of the inspiratory sensor 40 and the O ₂ concentration meter and the expiratory flow meter 36 continues for a few seconds during the operation of the system, the system determines that the gas is leaking from the hood, issues an alarm, and stops. In addition, when the hydrogen concentration of the suction gas is higher than a certain standard, a detonation arrester may be incorporated in the exhalation and suction confluence part 35. When the short-term average of the expiratory volume in the user's treatment is lower than the registered expiratory volume by a certain amount, it means that the system's respiratory volume is small. In addition, the standard expiratory volume can be registered by using a sensor of 36, which can be registered in advance by testing. The other difference from Embodiment 1 is that the hardware adapts to wireless technology. As an example of the specification of the device, as an example, the maximum amount of hydrogen generated is 2.4L per minute, the maximum amount of generated oxygen is 9.0L, the amount of generated nitrogen is 30L (estimated), and the power is within about 2KW.

In addition, regarding the therapeutic effect of this example, one example of the results of the clinical experiment is briefly described.

In the case of patients with cerebral infarction, after 6 months of onset, there was slight paralysis on the right hand side, and there were slight problems with memory and cognitive ability. Therefore, in order to create a hypoxic state, a closed nasal mask made by Philips was used, and a large amount of hydrogen was used to inhale the low oxygen for breathing.

The center of breathing is the appearance of hypoxic conditions for about 5 minutes. The subsequent reoxidation step (the step of inhaling the usual air and breathing) is performed for 60 minutes to 90 minutes. The minimum expiratory oxygen concentration in a very short time is about 5%.

The change started, about 5 minutes to 10 minutes, and the eyes felt the change due to the experiment in the room. Notice that the light from the fluorescent light changes slightly to red. This operation was continued for about 40 days.

As a result, the midway nerve felt a change. First of all, with regard to the eyes, a visual improvement is felt. Although the vision has not improved, what you see changes, it is very detailed, and the visual image changes delicately. I feel as if I have changed from an old TV to a 4K LCD TV. However, vision has not improved. Further, the experiment was continued using other devices. Regarding memory, short-term memory, called working memory, is particularly elevated.

It is hard to forget where objects are placed in daily life. Furthermore, the changes in cognitive abilities identified around 40 days from the start of the clinical trial were surprising, with incredible changes.

The confirmation method is carried out by sitting in the forefront of the route bus of the public transportation organization and observing the external scenery that gradually changes as the bus progresses. Before the experiment, the change of the surrounding traffic was not visually noticeable. However, after 40 days after the clinical trial, although the bus stopped near the intersection, if the attention was focused on the surrounding noise, At any three points (three places) such as the movement of bicycles, pedestrians, and other cars, changes occur as if each person's movements can be clearly grasped.

Furthermore, when referring to the movements of pedestrians or bicycles, if the consciousness is focused on one point and the vision is concentrated, the movements slowly feel the change as if seeing slow motion. Therefore, a breathing method in which the oxygen concentration is changed stepwise by reoxygenation from hypoxic breathing can be said to activate and regenerate brain nerve cells in the brain, particularly in the hippocampus.

The particularly vulnerable part of the brain around the hippocampus is the early response to hypoxia, or hypoxia.

Then, it is not re-oxidized after the hypoxic respiration treatment, but changes to high-oxidation, that is, breathing in a high-oxygen concentration region (oxygen concentration of 21% or more). The experiments so far have significantly improved working memory, but the association from the short-term memory area to the long-term memory area has not functioned well. In order to improve this part, a wider part of the brain needs to be activated. The target strategy is the hyperoxia area Breathing in.

If you first try a high-oxygen-only respiration of about 60 minutes for about 2 weeks and examine the results, you can indeed move relatively smoothly from short-term memory to long-term memory. Therefore, if the breathing from the hypoxic zone is continuously performed for about 60 minutes, and then the evaluation is performed 30 days later, the short-term memory, long-term memory, and cognitive ability will further evolve.

In terms of brain function and ability, compared with the state before the onset of cerebral infarction, it also exceeds the standard of ordinary people. Judging according to the speed of this change, causes the initialization of the mitochondrial genome of brain cells, and thus in the cell cycle. The division of the mitochondria of the nerve cells results in the improvement of the function of the nerve cells. The time responsiveness and the estimated effect are almost the same as the actual ones.

This time, the focus will be on the part of the brain cells, but the relationship is also established in other organs, etc. Among other opportunities, the opportunity for clinical trials is not planned.

<Example 3>

FIG. 6 shows a third embodiment. In Example 3, the oxygen partial pressure in the high oxygen concentration region is further increased. For users who have low active oxygen production, patients with low reactivity, etc., usually after the breathing in the low oxygen concentration region is completed before entering the pressurized chamber, the high oxygen concentration is used. Barometric therapy device. The compression time is set to about 15 minutes. Therefore, the compression time and the decompression time are combined to perform high-pressure oxygen therapy for about 60 minutes. After the hyperbaric oxygen treatment is completed, hydrogen is contained for about 30 minutes at normal pressure to stabilize the breathing to prevent side effects.

In addition, I heard that the recent high-pressure oxygen therapy device is not filled with oxygen in the internal space, but uses air for internal pressure, and uses a breathing mask to perform oxygen breathing for patients. In this case, the mask can also be used for breathing in hypoxic areas.

<Example 4>

Fig. 22 shows the exercise therapy for prevention of dementia, and the regenerative medical system using the breathing method which changes the oxygen concentration stepwise according to the present invention can greatly improve the prevention effect of exercise therapy for dementia. In FIG. 22, in a facility for exercise therapy, there are two closed rooms, a passageway and a connecting door connecting the two rooms, which can be closed to each other, a door from each room to the indoor sports field, and a door (not shown). An indoor environment control device that manages the temperature and humidity of the internal gas components in each hermetically sealed room.

In FIG. 22, the user (possibly plural) who has finished the preventive gymnastics and exercise therapy immediately enters the inside of the hypoxic treatment room from the closed door of the external opening and closing entrance. Here, after breathing in the hypoxic zone for the time determined by each person, the contact door is opened and closed to enter the adjacent high oxygen concentration treatment room, and breathing in the hyperoxic zone is performed for about 40 minutes to 60 minutes. After closing, open and close the exit door and walk out to the original indoor stadium. Thus, the treatment in the present invention ends.

Before exercising, users are expected to avoid taking antioxidants such as vitamin C. Regarding the setting of the oxygen concentration in the low oxygen concentration treatment room, since the user is already in a state of requiring low oxygen, the supply of low oxygen state is added to the room, so the oxygen concentration can also be increased compared to the usual setting. There is no special requirement for the hydrogen concentration in the room, it is usually set to 4%. The carbon dioxide generated by breathing in the room is removed by a carbon dioxide adsorbent inside the indoor environment control device. In the hyperoxia treatment room, here is drawn in a standing position, but because of the long time, you can also sit in a chair for treatment. Users can use the treatment room at any time, so if the user groups are divided into classes and exercise therapy is performed for each group staggered, a large number of users can efficiently receive the treatment of the present invention.

<Example 5>

FIG. 23 is an example of a large-scale treatment system using a fully automatic electric wheelchair to connect the closed hypoxic area treatment room and the closed hypoxic area treatment room with a closed path, and is a fifth embodiment. The user starts treatment by all sitting in the electric wheelchair 42 controlled by automatic operation. Users who have been using wheelchairs are also transferred to the electric wheelchair 42 for treatment here. Of course for healthy people. The electric wheelchair 42 is easy to understand when considering the evolution of the professional pilot chair (ProPilot chair) developed by Nissan.

Closed entrance paths 45 to the hypoxic area treatment room, closed contact passages 46 from the hypoxic area treatment room to the hyperoxic area treatment room, and closed closed paths 47 from the hyperoxic area treatment room. A sensor for position information is embedded in the floor. Sensors with position information are also embedded in the floor of the treatment room of the hypoxic area treatment room 60 and the hyperoxic area treatment room 61. Furthermore, an electromagnetic charging device for charging the electric wheelchair is installed on a floor surface at a suitable place where the electric wheelchair is fixed on the floor of the high-oxygen area treatment room 61 and the electric wheelchair is stopped (parked). Draw a diagonal line in the quadrangle / indicates the electric wheelchair and its number.

The closed door at the entrance is automatically opened for use by user No. 42, and the closed door at the back is closed at this time. The closed door between the closed entrance passage 45 to the hypoxic area treatment room and the hypoxic area treatment room 60 is internally locked in such a manner that the door is opened when the entrance door is closed. Usually, the doors between rooms or pathways are controlled by the system in such a way that they must not open on both sides. When it is fully opened, it is only for emergency and emergency. Each contact channel can have 3 persons.

There may be 10 users in the room of the hypoxic area treatment room 60. There can be 40 users in the room of the hyperoxic area treatment room 61. The difference in the number of users is due to the setting of 60% oxygen concentration in the hypoxic area treatment room between 18% and 14%, and the estimated hydrogen concentration of 4%. The maximum user life is assumed to be within 15 minutes. Here, in the hyperoxic area treatment room 61, the maximum existence time of the user is assumed to be within 60 minutes. Therefore, the balance of treatment capacity is achieved by the treatment time. In the treatment room of the hyperoxic area treatment room 61, it is assumed that the oxygen concentration is between 30% and 40%. In order to manage the gas balance, temperature and humidity, and indoor airflow in each treatment room, the gas supply system 53 for the hypoxic area treatment room and the high oxygen area treatment room 54 for the gas supply system 54 Although the integrated environmental management system is not shown, there is an integrated management system using a computer.

Here, when the user of the 56th uses the system for the first time, the breathing time in the hypoxic area treatment room 60 is started from the minimum. Similarly, the breathing time in the treatment room of the hyperoxic area treatment room 61 is also set to a minimum. Currently, if the hypoxic zone treatment room 60 is set to 5 minutes and the hyperoxic zone treatment room 61 is set to 20 minutes, the user's treatment time is 25 minutes plus the time required for movement. About 5 minutes, and ended in 30 minutes. Then study the user's treatment results, if there is no problem, gradually extend the time each time.

Referring to the top view, there are passages for electric wheelchairs around the existence of electric wheelchairs, and each electric wheelchair can be exposed on the side of the passage so as not to be hindered by other electric wheelchairs' forward path. By managing the entrance and exit routes, smooth operation can be achieved. Even when each person's time is different, the computer's integrated management system controls the sequence or timing of movement, so steps can be organized without futility.

However, accidents are inevitable. In this electric wheelchair, a wireless pulse oximeter is attached to the core user, which can remotely monitor necessary signal data. If there is an abnormality, only the user can be urgently transferred to the outdoors. In an emergency, each emergency has priority over other actions, so each channel is opened and transferred to the treatment room via the nearest channel. In the event of an emergency such as an earthquake or a nearby fire, the system instructs all treatment rooms, all doors of the access path, and all non-used doors with automatic opening and closing closed doors 44 to be opened by the control of the system. Electric wheelchairs Move outward from the nearest place, or move the electric wheelchair to the safest place when the dangerous place is near.

In the treatment room of the hyperoxic area treatment room 61, there is a relatively long breathing time, so the battery of the electric wheelchair can be charged (electromagnetic induction charging) as needed.

In addition, in the case where the electric wheelchair fails and cannot be moved, an automatic van for moving out a similarly automatic moving vehicle is moved and carried out between other steps. Previously, empty electric wheelchairs rescued users, transferred them to users, and performed subsequent steps for users.

In the device shown in Fig. 23, user treatment can be performed by 40 to 70 patients per hour. Operates 8 hours per day and can treat 320 to 560 people. If 500 people are treated a day, 10,000 people can treat or prevent 10,000 dementias in 20 days. This system is a system that achieves a balance between safety and efficiency, not only for dementia, but also for many diseases caused by mitochondrial insufficiency.

(Industrial availability)

Use a special breathing machine made by combining a device that supplies oxygen, nitrogen, and hydrogen, and use various masks to automatically breathe in a low-oxygen area with an oxygen concentration of 18% or less under appropriate conditions and automatically control the program. Breathing in a hyperoxic region with a concentration of 21% or above can relatively safely and efficiently arouse the initialization of the mitochondrial genome of the cell. The regenerative medical system using a programmed control breathing method can initialize the mitochondrial genome and change the reduced mitochondrial function into a healthy function mitochondria through the cell cycle, which can improve mitochondria. Symptoms of all diseases with hypofunction or mitochondrial insufficiency. Especially for dementia, there is also the ability to improve cognitive ability or memory. At present, there is no effective method for all pharmaceutical companies, and other regenerative medicines also have high treatment costs. Among them, the present invention combines an existing breathing machine and the like, and adds a progressive system setting, thereby processing into an advanced regenerative medical system. It can also relatively ensure safety and excellent treatment efficiency. Because it is a structure that can withstand mass production, it can be used as a center for future regenerative medicine and exert its full effect.

Claims (22)

    A medical system for increasing the concentration of active oxygen in brain nerve cells, comprising: a gas supply unit capable of supplying at least low oxygen with an oxygen concentration of 18% or less and high oxygen with an oxygen concentration of 21% or more to a human or animal subject; and A control unit that controls the oxygen concentration of the gas supplied from the gas supply unit to the supply target; the control unit controls the time when the gas supply unit supplies the gas with a predetermined oxygen concentration to the supply target; the control unit controls the foregoing in the following manner The gas supply unit: after supplying the low oxygen to the supply target, supplying the high oxygen for more than 10 minutes to the supply target, and then ending the gas supply.         The medical system for increasing the active oxygen concentration in a brain nerve cell according to claim 1, wherein the control mechanism controls the gas supply unit in the following manner: first supplying the low oxygen to the supply target for more than one minute Thereafter, the supply of the high oxygen gas is performed on the supply target for more than 10 minutes, and then the supply of the gas is terminated.         A medical system for increasing the concentration of active oxygen in brain nerve cells, comprising: a gas supply unit capable of supplying at least low oxygen with an oxygen concentration of 18% or less and high oxygen with an oxygen concentration of 21% or more to a human or animal subject; and A control mechanism controls the oxygen concentration of the gas supplied from the gas supply unit to the supply target; the control mechanism controls the gas supply unit in the following manner: after the low oxygen supply is performed on the supply target, the supply target is performed for 10 minutes The above-mentioned high oxygen supply is not performed, and then the aforementioned low oxygen supply is not performed.         The medical system for increasing the active oxygen concentration in a brain nerve cell as described in claim 3, wherein the control mechanism controls the gas supply unit in the following manner: first supplying the low oxygen to the supply target for more than one minute Thereafter, the supply target is supplied with the high oxygen for more than 10 minutes, and then the supply of the low oxygen is not performed.         The medical system for increasing active oxygen concentration in a brain nerve cell according to any one of claims 1 to 4, wherein the gas supply unit can supply a gas containing oxygen and nitrogen to the supply target; The ratio of nitrogen in the supplied gas is controlled to control the oxygen concentration in the gas supplied from the gas supply unit to the supply target.         The medical system for increasing the active oxygen concentration in a brain nerve cell according to any one of claims 1 to 5, further comprising an oxygen-nitrogen concentrator as a generation source of oxygen and nitrogen supplied from the gas supply unit, It has the ability to separate air into oxygen and nitrogen.         The medical system for increasing active oxygen concentration in a brain nerve cell according to any one of claims 1 to 6, wherein the gas supply unit can supply a gas containing oxygen and hydrogen to the supply target; The ratio of nitrogen in the supplied gas is controlled to control the oxygen concentration in the gas supplied from the gas supply unit to the supply target.         The medical system for increasing the active oxygen concentration in a brain nerve cell according to claim 7, comprising a breathing mask for supplying gas to the aforementioned supply target, and a safety exhaust mask arranged to cover the outside of the breathing mask And a suction mechanism for sucking exhaust gas from the safety exhaust hood; the safety exhaust hood is used to create a gap between the breathing hood and the face of the supply subject when the breathing hood is worn on the face of the supply subject; When the breathing mask is worn on the face of a supply subject and gas is supplied to the supply subject, a hydrogen mixed gas leaking from the breath is drawn out from the gap between the safety exhaust hood and the face and the surrounding air Inhale, reduce the hydrogen concentration of the aforementioned hydrogen mixed gas by stirring and mixing with air, dilute it to below the flammable explosive concentration, and safely exhaust it indoors or outdoors.         The medical system for increasing the active oxygen concentration in a brain nerve cell according to any one of claims 1 to 8, comprising a pulse oximeter that senses percutaneous arterial oxygen saturation of a subject to be supplied; the aforementioned control mechanism and When the pulse oximeter is connected, the control mechanism controls the gas supply unit in the following manner: during the supply of the low oxygen to the supply target, the percutaneous arterial blood oxygen of the supply target as sensed by the pulse oximeter When the saturation is lower than a predetermined value, the supply target starts to supply the aforementioned high oxygen.         The medical system for increasing the active oxygen concentration in a brain nerve cell according to any one of claims 1 to 9, wherein the gas supply unit includes a pressurized gas supply device; the medical system includes: a high-pressure chamber; The pressurized gas from the pressurized gas supply device is supplied, and the supply target can be accommodated.         The medical system for increasing the active oxygen concentration in a brain nerve cell according to any one of claims 1 to 10, comprising: a transcranial current stimulation device or a low-frequency treatment device; the transcranial current stimulation device includes a transcranial current stimulation device The electrical stimulation unit is an electrical stimulation unit applied to the scalp of the subject, and the low-frequency treatment device includes an electrode that applies a low-frequency current to the subject.         An active oxygen concentration increasing agent in brain nerve cells, which is composed of low oxygen with an oxygen concentration of less than 18% and high oxygen with an oxygen concentration of more than 21%; and is used in the following way: first supply the aforementioned low oxygen to humans or animals After the supply target is supplied, the high oxygen is supplied to the supply target for more than 10 minutes, and then the supply target is not supplied.         An active oxygen concentration increasing agent in brain nerve cells, which is composed of low oxygen with an oxygen concentration of less than 18% and high oxygen with an oxygen concentration of more than 21%; and is used in the following way: first supply the aforementioned low oxygen to humans or animals After the supply target, the supply target is supplied with the high oxygen for more than 10 minutes, and then the supply target is not supplied with the low oxygen.         The agent for increasing active oxygen concentration in a cerebral nerve cell according to claim 12 or 13, wherein the agent is used for treating a neurological disease.         A medical system is provided with a low-oxygen chamber filled with low oxygen with an oxygen concentration of 18% or less and a high-oxygen chamber filled with high oxygen with a oxygen concentration of 21% or more; the aforementioned medical system is provided with a supply for placing people or animals The object moves in parallel with the moving body; the moving system is controlled by the control unit to move automatically in the low oxygen room, the high oxygen room, and the outdoor; the control unit is used to control the moving body as shown below: The moving body moves to the high-oxygen chamber after a preset time has passed inside the low-oxygen chamber, and after more than 10 minutes have passed inside the high-oxygen chamber, it moves outside.         A method for increasing the concentration of active oxygen in brain nerve cells is to provide human or animal subjects with at least a low oxygen concentration of less than 18%, and then a high oxygen concentration of 21% or more for more than 10 minutes, and then The supply of the low oxygen and the high oxygen is performed.         A method for increasing the concentration of active oxygen in brain nerve cells is to provide human or animal subjects with at least a low oxygen concentration of less than 18%, and then a high oxygen concentration of 21% or more for more than 10 minutes, and then The aforementioned low oxygen supply is performed.         A method for increasing the concentration of active oxygen in brain nerve cells. The subject of human or animal inhalation should first inhale low oxygen with an oxygen concentration of at least 18%, and then inhale oxygen with an oxygen concentration higher than atmospheric gas for more than 10 minutes. Do not inhale the aforementioned low oxygen and the aforementioned high oxygen.         A type of low oxygen and high oxygen used as an active oxygen concentration increasing agent in brain nerve cells. It is used to supply human or animal at least low oxygen concentration below 18%, and then oxygen concentration above 10 minutes. 21 High oxygen, the supply of low oxygen and high oxygen are not performed.         A type of low oxygen and high oxygen used as an active oxygen concentration increasing agent in brain nerve cells. It is used to supply human or animal at least low oxygen concentration below 18%, and then oxygen concentration above 10 minutes. 21 High oxygen, and then the aforementioned low oxygen supply is not performed.         A kind of low oxygen and high oxygen used to produce active oxygen concentration increasing agent in brain nerve cells. It is used to supply at least low oxygen concentration below 18% to humans or animals, and then supply oxygen for more than 10 minutes. High oxygen with a concentration of 21% or more is not supplied with the aforementioned low oxygen and the aforementioned high oxygen.         A kind of low oxygen and high oxygen used to produce active oxygen concentration increasing agent in brain nerve cells. It is used to supply at least low oxygen concentration below 18% to humans or animals, and then supply oxygen for more than 10 minutes. After the high oxygen concentration of 21% or higher, the aforementioned low oxygen supply is not performed.