WO2019074256A1 - Composition cosmétique possédant des effets de prévention et d'atténuation du vieillissement du cuir chevelu et de prévention de la chute des cheveux - Google Patents

Composition cosmétique possédant des effets de prévention et d'atténuation du vieillissement du cuir chevelu et de prévention de la chute des cheveux Download PDF

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Publication number
WO2019074256A1
WO2019074256A1 PCT/KR2018/011848 KR2018011848W WO2019074256A1 WO 2019074256 A1 WO2019074256 A1 WO 2019074256A1 KR 2018011848 W KR2018011848 W KR 2018011848W WO 2019074256 A1 WO2019074256 A1 WO 2019074256A1
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Prior art keywords
preventing
composition
extract
hair loss
hair
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PCT/KR2018/011848
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English (en)
Korean (ko)
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박진오
이지원
박병권
최아람
김아름
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유씨엘 주식회사
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Priority to CN201880055224.9A priority Critical patent/CN111315348B/zh
Publication of WO2019074256A1 publication Critical patent/WO2019074256A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/606—Nucleosides; Nucleotides; Nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the present invention relates to a cosmetic composition having an effect of preventing and alleviating scalp aging and preventing hair loss.
  • alopecia refers to an increase in the number of abnormal hair loss due to shortening of hair growth rate in the growing period and increased number of hair in the retrogressive or resting period among these cycles.
  • the cause of known hair loss may be influenced by various factors such as age, season, race, physiological factors, and disease, but it can be affected by 1) male hormone hyperactivity, 2) excessive sebaceous secretion, 3) 4) depression of the scalp due to peroxidation and bacteria, 5) genetic factors, 6) aging, and 7) stress.
  • dandruff diseases such as dandruff and seborrheic dermatitis are widely known to be accompanied by typical early symptoms.
  • scalp inflammation is caused by various pollutants, skin hypersensitivity to bacteria.
  • the genetic factors such as nervous system disorder, blood circulation disorder, excessive sebum production caused by abnormal circulatory system, nutritional deficiency of hair follicle, allergy, bacterial infection, hormone effect, various pollution.
  • a combination of mental and social factors and aging of modern people who are frequently exposed to environmental factors and excessive stress such as shampoo, soap, mousse, hair gel, hair spray, permer, dyeing, hair dryer and detergent are known.
  • hair loss products including effective ingredients such as blood circulation promotion, hair root enhancement effect, scalp moisturizing effect, anti-dandruff effect, antioxidant effect, hair growth period extension effect and suppression of male hormone function.
  • effective ingredients such as blood circulation promotion, hair root enhancement effect, scalp moisturizing effect, anti-dandruff effect, antioxidant effect, hair growth period extension effect and suppression of male hormone function.
  • efficacy it has not yet been proven to have significant effects, and side effects may be raised.
  • Patent Document 1 can be exemplified as a conventional technology for an anti-hair loss agent using such a natural extract.
  • the patent discloses a composition for preventing hair loss or promoting hair growth, comprising a mixed extract of green tea and amaranthus, or a mixed extract of green tea, green tea and hibiscus as an active ingredient, and discloses a natural combination extract. The effectiveness is significantly different.
  • Patent Document 1 KR 10-1780692 B1 (May 27, 2017)
  • the present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a hair loss prevention composition which prevents, alleviates and prevents hair loss by preventing, alleviating and preventing hair aging, And an anti-hair loss agent using the same.
  • Menthol, salicylic acid, adenosine, and dexpanthenol Menthol, salicylic acid, adenosine, and dexpanthenol.
  • the composition provides an anti-depressant composition having an effect of alleviating, preventing and preventing scalp aging.
  • composition of the present invention may further comprise at least one surfactant selected from the group consisting of: 0.05-2 wt% menthol, 0.05-2 wt% salicylic acid, 0.01-0.5 wt% adenosine, and 0.05-15 wt% dexpanthenol,
  • at least one surfactant selected from the group consisting of: 0.05-2 wt% menthol, 0.05-2 wt% salicylic acid, 0.01-0.5 wt% adenosine, and 0.05-15 wt% dexpanthenol
  • the additional component provides an anti-depilatory composition having a total content of 0.01 to 20% by weight based on the total weight of the composition.
  • a cosmetic product for preventing hair loss which comprises the composition of the present invention and is manufactured from a cream, lotion, essence, serum, toner, tonic, and mist.
  • an antioxidant containing menthol, salicylic acid, adenosine, and dexpanthenol of the present invention can prevent, alleviate or prevent scalp aging, thereby improving hair loss prevention effect.
  • FIG. 1 is a graph showing changes in hair loss preventing effect, hair size, and hair density before and after use of the hair loss preventing agent of the present invention.
  • first, second, A, B, (a), (b), and the like can be used. These terms are intended to distinguish the constituent elements from other constituent elements, and the terms do not limit the nature, order or order of the constituent elements.
  • " about, " " substantially, " and " degree ", etc. used to describe the present invention should be understood to include both manufacturing and material tolerances inherent to the stated meanings, And is used to prevent unauthorized use by an unscrupulous infringer of an explicit or absolute number for the purpose of facilitating the understanding of the present invention.
  • An anti-depressant composition for preventing, alleviating and preventing scalp aging may include menthol, salicylic acid, adenosine, and dexpanthenol.
  • the menthol is a component used for stomach cramps and toothache, and is good for pain and inflammation, and has an effect of cooling the scalp, so that the feeling of cooling of the scalp can be added.
  • the menthol preferably contains 0.05-2% by weight, more preferably 0.1-1.0% by weight, based on the total weight.
  • the content of menthol When the content of menthol is less than 0.05% by weight, the efficacy and the effect are insignificant. When the content of menthol is more than 2% by weight, excessive cooling or irritation may occur and the formulation may be unstable.
  • the salicylic acid is widely used for skin-related diseases such as acne, dandruff, keratin and corn, and has a property of softening the anti-inflammatory and scalp keratin so as to remove old keratin and waste products remaining inside the pores You can do it.
  • Salicylic acid preferably contains 0.05-2% by weight based on the total weight of the composition, and if it exceeds 0.1-1% by weight, skin irritation may occur.
  • the adenosine is a component which promotes the synthesis of collagen, alleviates wrinkles and improves skin elasticity.
  • the adenosine preferably contains 0.01-0.5 wt%, more preferably 0.02-0.2 wt%, based on the total weight.
  • the effect and the effect are insignificant and the effect of improving the elasticity of the scalp is insignificant. If the content exceeds 0.5% by weight, stability in the product deteriorates and the effect is not improved. There may be a possibility of occurrence.
  • Dex Panthenol is a protein that is converted into vitamins after being absorbed into the body. It can prevent inflammation and itching, soften hair, and enhance hair strength.
  • the dexpanthenol preferably contains 0.05 to 15% by weight, more preferably 0.1 to 10% by weight, based on the total weight.
  • the antioxidant composition capable of preventing, alleviating and preventing the scalp aging, retinol, tocopherol, ascorbic acid, collagen, an extract of anthocyanin, an extract of a common ginseng root, an extract of an iris, a thistle flower / Extract, propolis extract, horseradish extract, Jeju balsam extract, and hosepat.
  • the retinol is a kind of vitamin A, and plays an important role in maintaining the original function of the epidermal cells of the skin. Especially, it is an effective ingredient for improving wrinkles and preventing skin aging.
  • the tocopherol is a kind of vitamin E which is a fat-soluble vitamin. It has an antioxidant effect and inhibits the oxidation of the unsaturated fatty acid constituting the cell membrane, thereby preventing damage to the cell membrane and further damage to the tissue. It is a highly effective ingredient.
  • Ascorbic acid is one of the water-soluble vitamins and is an antioxidant that is vitamin C. It protects the body from active oxygen to prevent oxidation of the cells and also plays an important role in protecting the skin from ultraviolet rays.
  • the moisturizing power is remarkably increased, and in particular, the texture is improved and the composition can improve the feeling of use.
  • Ishigaki is an Araliaceae plant which is a reclaimed land of Jeju Island.
  • the extracts of the common astringent ginseng have no cytotoxicity, and are excellent in anti-inflammatory effect by inhibiting various cytokines and NO activity mediated by inflammatory reaction, and can be effective in preventing skin aging and strengthening skin barrier due to high antioxidant effect .
  • the iris is distributed in Korea, Japan, and China. It is a perennial herb that grows in a pond or a ditch. In oriental medicine, the function of an organ such as eyes, nose, mouth, ear, urethra and anus in our body Helps to release toxins in the body, detoxification function, anti-bacterial and anti-inflammatory effect is high, "There is a tradition of bathing hair with boiled water with irrigation on the monolith.” Especially, the root of iris is excellent for the improvement of fragile constitution, and it is known that essential oil of iris can solve blood circulation, pain, fatigue, and especially antioxidant efficacy is excellent.
  • the thistle is a perennial plant of Asteraceae.
  • the flower / leaf / stem extract is applied to the skin by applying a thistle outpost extract that promotes ARE protein activity related to the antioxidant protein Nrf-2, Maintains homeostasis and prevents skin aging by active oxygen.
  • the propolis is excellent in organic matter and minerals. Especially, minerals, vitamins, amino acids, fats, organic acids, flavonoids and the like play an important role in cell metabolism, terpenes and the like have anticancer activities, and flavonoids help health promotion give. This propolis has anti-inflammatory, antioxidant, immunity enhancing effects.
  • Mahi-hyeon is also called a horsetail, in other words, a leaf-shaped horsetail that hits the teeth of a horse and eats salmon. It is known that there are many omega - 3 fatty acids, which are a type of unsaturated fatty acid, and this extract has excellent antioxidative and anti - inflammatory properties.
  • the bamboo sage is a monocotyledonous plant of the paddy field distributed in Korea and Japan.
  • the bamboo sage berry in Jeju is cold and snowy, has a life span of 60-120 years, and is effective in preventing cancer, antioxidation and obesity It is known, and especially has a very high moisturizing effect.
  • the hose fat is an excellent antioxidant and anti-inflammatory ingredient, and can maintain skin homeostasis and prevent skin aging by promoting ARE activity associated with antioxidant protein Nrf-2.
  • the extracts of the above-mentioned extracts such as anthocyanin extracts, common astringent extracts, iris root extracts, thistle flower / leaf / stem extracts, propolis extracts, It is desirable that Jeju Island, which is a clean area designated as Biosphere Reserve Area, is a native area.
  • the anti-depressant composition according to the present invention is excellent in efficacy as an anti-depilation agent, and can prevent or alleviate the aging of the scalp, thereby alleviating and alleviating hair loss which can be accelerated thereby. Will be self-evident.
  • the anti-depressant composition is prepared in the form of a cream, lotion, essence, serum, toner, tonic, mist, etc., and is applied to the scalp to make the scalp healthy.
  • the anti-depilator composition can prevent, Can be used.
  • composition ratios of Production Example 1-7 and Comparative Example 1-2 described in the following Table 1 purified water, glycerin, butylene glycol, 1,2hexanediol, disodium edetate were dissolved and heated to about 70 ° C
  • solution 1 was mixed with a mixture of caprylic / capric triglyceride, triethylhexanone, cetearyl alcohol, cyclopentasiloxane, palmitic acid, stearic acid, cyclohexasiloxane, Sorbate 60, PGI-100 stearate, glyceryl stearate, and sorbitan stearate were added and heated to about 70 ° C to dissolve them to prepare solution 2.
  • the solution 2 thus prepared was added to Solution 1, mixed and emulsified. After cooling, components 3 were added and uniformly mixed to prepare an anti-depilation composition having an effect of alleviating scalp aging.
  • the hair loss inhibitor which has the effect of preventing, alleviating and preventing scalp, prepared according to the above Table 1 was applied to 18 adult male and female subjects each morning and evening. After 6 months, , Hair thickness and hair density were measured according to a predetermined evaluation method, and the average value was calculated and evaluated. The results are shown in Table 3 below.
  • the total amount of hair removed after hair washing after 6 months of use and before use was 2 for each of 18 male and female adults who had hair loss phenomenon in the hair loss prevention agent having the effect of preventing, And evaluated according to the evaluation criteria shown in Table 2 below. The results are shown in Tables 3 to 5.
  • Folliscope 4.0 (Lead M, Korea), a device for analyzing the characteristics of hair based on photographs taken using a high resolution digital close-up camera, was used to measure the thickness of the hair by phototrichogram. was used to measure the test site.
  • the measurement method used the scalp of a certain area (1 cm 2), and the average value of the thicknesses of five hairs in the area was used as evaluation data. The results are shown in Table 4 and FIG.
  • Folliscope 4.0 (Lead M, Korea), a device for analyzing the characteristics of hair based on photographed photographs using a high-resolution digital close-up camera, was used to measure the hair density, which was measured by phototrichogram. was used to measure the test site.
  • the hair loss preventive agent having the effect of preventing, alleviating and preventing scalp produced according to the above Table 1 was applied to each of nine adult males and females in the morning and evening after their hair was wound. After 6 months, Moisture content was measured according to a predetermined evaluation method, and the results were as shown in Tables 6 and 7 below.
  • the evaluation method for scalp elasticity measures the hairline elasticity.
  • Cutometer CM580 was used and the area of the forehead hairline was measured.
  • the measurement was performed at the same site before and after the use of the hair loss preventing agent to prevent, mitigate and prevent the scalp aging according to the present invention, and R 2 (skin re-elasticity) value was used as skin elasticity evaluation data.
  • the R 2 value is the overall elasticity, which means that the closer to 1 the more elastic the skin.
  • Examples 1 to 7 using the antioxidant preventing, mitigating and preventing anti-aging agent of the present invention significantly increased the elasticity of the hairline as compared with Comparative Examples 1 and 2.
  • the density of the hair was changed to 98% and 108% before use and 6 months after use, whereas Examples 1 to 7 increased to 112-147%.
  • the moisture content of the scalp was measured using a Corneometer CM825 (Courage-Khazaka electronic GmbH, Germany). Measurements were made three times through a sensor with a corneometer probe on the skin, and the average value was used as the skin moisture content evaluation data.
  • the Corneometer is a device that basically treats skin as a non-conductive material and applies electricity with a higher water content. It measures the capacitance at the point where the probe touches. Therefore, the moisture content and the capacitance are proportional to each other, and the higher the measured value, the higher the moisture content.
  • the water content which is within 30-40 micrometer depth downward from the stratum corneum of the skin, is constantly measured, and the unit is the unit constant, the arbitrary unit (A.U).
  • Table 7 shows that when the compositions of Comparative Examples 1 and 2 were used, the moisture content increased before use, but Examples 1 to 7 using the hair restoration composition for alleviating scalp skin of the present invention showed 300-900% The water content of the scalp increased.

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Abstract

La présente invention concerne une composition cosmétique possédant des effets de prévention et d'atténuation du vieillissement du cuir chevelu et de prévention de la chute des cheveux et, plus spécifiquement, une composition d'agent contre la chute des cheveux contenant du menthol, de l'acide salicylique, de l'adénosine et du dexpanthénol. L'utilisation d'un agent contre la chute des cheveux contenant du menthol, de l'acide salicylique, de l'adénosine et du dexpanthénol de la présente invention peut prévenir, atténuer et empêcher le vieillissement du cuir chevelu, et améliore l'effet contre la perte des cheveux en résultant.
PCT/KR2018/011848 2017-10-10 2018-10-08 Composition cosmétique possédant des effets de prévention et d'atténuation du vieillissement du cuir chevelu et de prévention de la chute des cheveux WO2019074256A1 (fr)

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CN201880055224.9A CN111315348B (zh) 2017-10-10 2018-10-08 具有防止和缓解头皮老化以及防止脱发的效果的化妆品组合物

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KR10-2017-0129188 2017-10-10
KR1020170129188A KR102054160B1 (ko) 2017-10-10 2017-10-10 두피노화 예방 및 완화, 및 탈모방지 효과가 있는 화장료 조성물

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WO2024042410A1 (fr) 2022-08-26 2024-02-29 Dyson Technology Limited Système de purification d'air

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CN116209425A (zh) * 2020-07-14 2023-06-02 株式会社Lg生活健康 用于防止脱发和促进生发的组合物
KR102492955B1 (ko) * 2020-11-29 2023-01-31 (주)피알지에스앤텍 데커신 유도체를 포함한 발모제 조성물

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JP2011256114A (ja) * 2010-06-04 2011-12-22 Hakuto Co Ltd 頭皮用外用剤
JP2012184220A (ja) * 2011-02-17 2012-09-27 Lion Corp 頭皮頭髪化粧料
KR101509608B1 (ko) * 2014-12-29 2015-04-07 비오엠코스메틱 주식회사 두피 및 모발 상태 개선용 조성물
KR20170038674A (ko) * 2015-09-30 2017-04-07 (주)아모레퍼시픽 알콕시실란 화합물 또는 그의 염, 이의 제조방법 및 이를 포함하는 모발용 조성물

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024042410A1 (fr) 2022-08-26 2024-02-29 Dyson Technology Limited Système de purification d'air

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CN111315348B (zh) 2023-04-28
KR20190040426A (ko) 2019-04-18
KR102054160B1 (ko) 2019-12-10

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