WO2019062623A1 - 一种染发组合产品及其制备和使用方法 - Google Patents

一种染发组合产品及其制备和使用方法 Download PDF

Info

Publication number
WO2019062623A1
WO2019062623A1 PCT/CN2018/106533 CN2018106533W WO2019062623A1 WO 2019062623 A1 WO2019062623 A1 WO 2019062623A1 CN 2018106533 W CN2018106533 W CN 2018106533W WO 2019062623 A1 WO2019062623 A1 WO 2019062623A1
Authority
WO
WIPO (PCT)
Prior art keywords
hair
dye
polylysine
pretreatment liquid
combination product
Prior art date
Application number
PCT/CN2018/106533
Other languages
English (en)
French (fr)
Inventor
孙颖浩
Original Assignee
上海氪励铵勤科技发展有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 上海氪励铵勤科技发展有限公司 filed Critical 上海氪励铵勤科技发展有限公司
Publication of WO2019062623A1 publication Critical patent/WO2019062623A1/zh

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/88—Polyamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/31—Hydrocarbons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/733—Alginic acid; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/10—Preparations for permanently dyeing the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42—Colour properties
    • A61K2800/43—Pigments; Dyes
    • A61K2800/432—Direct dyes
    • A61K2800/4324—Direct dyes in preparations for permanently dyeing the hair

Definitions

  • the present invention relates to a combination product comprising a pretreatment liquid and a dye, a method of making and using the combination product, and the use of the combination product for hair dyeing.
  • the outermost layer of hair is the epidermis scale, inside which is the cortical cells, and the center of the hair is the pulp.
  • the middle of the cells are keratin that are bonded to each other.
  • Each cell forms keratin cellulose along the hair stem, and the spots in the cellulose are melanin particles. It is they who form the color of the hair.
  • Inorganic hair dyes currently on the market are mainly compounds containing metals such as lead, iron and copper. The metal ions in the hair dye penetrate into the hair, react with sulfur in the cysteine in the hair protein to form black lead sulfide, etc., and the user's hair is blackened.
  • the heavy metal ions contained in inorganic hair dyes are likely to cause accumulation of poisoning, which is very harmful to the human body. In addition to detrimental to the health of the hair, it can cause allergies, and can also cause various diseases.
  • Lead is easily absorbed by the body to form chronic poisoning. In the early stage of chronic poisoning, it feels tired and loss of appetite. It may cause visual impairment and regenerative anemia. Copper is absorbed by the body, and excessive deposition slowly promotes fat peroxidation, which causes arteriosclerosis and arterial fibrosis.
  • the synthetic hair dye is p-phenylenediamine to make the hair black, but p-phenylenediamine is carcinogenic.
  • the plant hair dye is a hair dye which is extracted from natural plants or made from natural plants, but its fastness is not good, and it will fade when shampooing after dyeing.
  • a combination product comprising or consisting of a pretreatment liquid and a dye paste
  • the pretreatment liquid comprises or consists of a cationic polymer
  • the dye is composed of a polymer polysaccharide, a petrolatum and a dye (selected from lemon yellow, carmine, brilliant blue, CB-2, basic red) 5 and one of acid yellow 2 or a combination of any two or more of them).
  • the cationic polymer is selected from the group consisting of polyethyleneimine, ⁇ -polylysine, and both
  • the polymeric polysaccharide is selected from the group consisting of sodium alginate, chitosan, and both.
  • the polyethyleneimine has a concentration of 1-400 mg/ml, preferably 50-150 mg/ml, 50-100 mg/ml, 100-150 mg/ml, more preferably 50 mg/ml, 100 mg/ml. Or 150 mg/ml, and the concentration of the ⁇ -polylysine is 1-400 mg/ml, preferably 50-300 mg/ml, 50-200 mg/ml, 50-160 mg/ml, 50-133.3 mg/ml, 50-100 mg/ml, 50-83.3 mg/ml, 83.3-300 mg/ml, 83.3-200 mg/ml, 83.3-160 mg/ml, 83.3-133.3 mg/ml, 83.3-100 mg/ml, 100-300 mg/ml, 100-200 mg/ml, 100-160 mg/ml, 100-133.3 mg/ml, 133.3-300 mg/ml, 133.3-200 mg/ml, 133.3-160 mg/ml, 160-300 mg/ml or 160-
  • the amount of the sodium alginate or chitosan is about 0.1-1.2 g, preferably 0.1 g, 0.2 g, 0.3 g, 0.35 g, 0.4 g, 0.5 g, 0.6 g, 0.7 g, 0.8 g. , 0.9 g, 1.0 g, 1.1 g, 1.2 g or a range between the respective amounts, for example, 0.2 to 1.1 g.
  • the amount of the petrolatum is 0.1-1.5 g, preferably 0.1 g, 0.2 g, 0.3 g, 0.4 g, 0.5 g, 0.58 g, 0.6 g, 0.7 g, 0.8 g, 0.9 g, 1.0 g, 1.1 g, 1.2 g, 1.3 g, 1.4 g, 1.5 g or a range between the respective amounts, for example, 0.2 to 1.4 g.
  • the dye i.e., one selected from the group consisting of tartrazine, carmine, brilliant blue, CB-2, basic red 5, and acid yellow 2, and combinations thereof
  • the dye is 1-20 ml, preferably 11-14 ml, more preferably 11 ml, 12 ml, 13 ml or 14 ml.
  • a process for the preparation of the above-mentioned combination product which comprises: preparing a dye using a polymer polysaccharide, petrolatum and a dye, wherein the polymer polysaccharide (prepared as an emulsifier) is selected from seaweed Sodium, chitosan, and combinations thereof, and a cationic polymer is used as the pretreatment liquid, wherein the cationic polymer is selected from the group consisting of polyethyleneimine, ⁇ -polylysine, and combinations thereof.
  • the method comprises: taking about 0.1-1.5 g of petrolatum (preferably 0.1 g, 0.2 g, 0.3 g, 0.4 g, 0.5 g, 0.58 g, 0.6 g, 0.7 g, 0.8 g, 0.9 g, 1.0 g) , 1.1 g, 1.2 g, 1.3 g, 1.4 g, 1.5 g or a range between the above amounts, for example, 0.2 to 1.4 g), sodium alginate or chitosan of about 0.1 to 1.2 g (preferably 0.1 g) , 0.2 g, 0.3 g, 0.35 g, 0.4 g, 0.5 g, 0.6 g, 0.7 g, 0.8 g, 0.9 g, 1.0 g, 1.1 g, 1.2 g or a range between the respective amounts, for example, 0.2- 1.1g), placed in a water bath at 50 ° C -90 ° C (preferably 60 ° C, 70 ° C or
  • a hair dyeing method using the above-described combination product comprising: spraying the hair with the pretreatment liquid, drying it after about 5 minutes; and then uniformly applying the dye to the dye On the treated hair, after about 10-15 minutes, a film is formed on the surface of the hair to complete the dyeing.
  • Figure 1 Effect of different pretreatment solutions on the hair dyeing effect of yak hair.
  • Figure 2 The effect of pretreatment solution containing ⁇ -polylysine on the hair dyeing effect of yak hair by electron microscopy.
  • Figure 3 Effect of the pretreatment solution containing ⁇ -polylysine on the hair dyeing effect of white human hair (Sample 1) by electron microscopy.
  • Figure 4 Effect of the pretreatment solution containing ⁇ -polylysine on the hair dyeing effect of white human hair (Sample 2) by electron microscopy.
  • Figure 5 The effect of pretreatment with ⁇ -polylysine on the hair coloring effect of yak hair after multiple washings by electron microscopy.
  • Figure 6 The effect of pretreatment with ⁇ -polylysine on the coloration of hair of different colors by electron microscopy.
  • Figure 7 is a schematic diagram of the beneficial effects of the combination product claimed in the present invention by providing a protective film on the surface of the hair product with a significant increase in washfastness.
  • the invention is based on the fact that the combination product of the invention comprises a pretreatment liquid composed of a cationic polymer and a polymer polysaccharide, a vaseline and a dye (Lemon yellow, carmine, brilliant blue, CB-2, basic red 5 and Acidic yellow 2) consisting of or consisting of dyes, firstly treating the hair with a pretreatment liquid consisting of a cationic polymer, and then applying a dye consisting of polymer polysaccharide, petrolatum and dye on the surface of the hair. They adsorb dye molecules by strong electrostatic adsorption and form a film on the surface of the hair, which not only reduces the toxicity of hair dye, but also increases the color fastness.
  • a pretreatment liquid composed of a cationic polymer and a polymer polysaccharide, a vaseline and a dye (Lemon yellow, carmine, brilliant blue, CB-2, basic red 5 and Acidic yellow 2) consisting of or consisting of dyes
  • a pretreatment liquid
  • hair and “hair” refer to any keratin-containing fiber or fiber material, including any human hair, animal hair (including but not limited to, rabbit hair, yak hair) and writing hair.
  • pigment is a white, black or colored powdered water-soluble or water-insoluble material that is used to render the pigment composition colored and/or rendered opaque.
  • hair color fastness refers to the ability of a color to withstand various factors while maintaining its original color to varying degrees, i.e., the ability to resist color change.
  • High hair fastness means that the color has high resistance to color change.
  • the color fastness is mainly reflected by the fact that after repeated washings (for example, 15-20 times), the color on the hair remains at different degrees to keep its original color from fading.
  • room temperature means 25 °C ⁇ 1 °C. At the same time, if the experimental temperature is not specified, it is room temperature.
  • the term "about” refers to ⁇ 20%, preferably ⁇ 10%, more preferably ⁇ 5% of the value modified by the term, so that one of ordinary skill in the art will be able to clearly modify Numerical values determine the scope of the term "about.”
  • a combination product comprising or consisting of a pretreatment liquid and a dye paste
  • the pretreatment liquid comprises or consists of a cationic polymer
  • the dye comprises a polymer polysaccharide, a petrolatum and a dye (selected from lemon yellow, carmine, brilliant blue, CB-2, alkaline red) 5 or a mixed dye of one or more of acid yellow 2), or consists of them.
  • the cationic polymer is selected from the group consisting of polyethyleneimine, ⁇ -polylysine, and combinations thereof
  • the polymeric polysaccharide is selected from the group consisting of sodium alginate, chitosan, and combinations thereof.
  • the polyethyleneimine has a concentration of 1-400 mg/ml, preferably 50-150 mg/ml, 50-100 mg/ml, 100-150 mg/ml, more preferably 50 mg/ml, 100 mg/ml or 150 mg/ml
  • concentration of the ⁇ -polylysine is 1-400 mg/ml, preferably 50-300 mg/ml, 50-200 mg/ml, 50-160 mg/ml, 50-133.3 mg/ml, 50 -100 mg/ml, 50-83.3 mg/ml, 83.3-300 mg/ml, 83.3-200 mg/ml, 83.3-160 mg/ml, 83.3-133.3 mg/ml, 83.3-100 mg/ml, 100-300 mg/ml, 100 -200 mg/ml, 100-160 mg/ml, 100-133.3 mg/ml, 133.3-300 mg/ml, 133.3-200 mg/ml, 133.3-160 mg/ml, 160-300 mg/ml or 160
  • the amount of the sodium alginate or chitosan is about 0.1-1.2 g, preferably 0.1 g, 0.2 g, 0.3 g, 0.35 g, 0.4 g, 0.5 g, 0.6 g, 0.7 g, 0.8 g.
  • the amount of the petrolatum is 0.1-1.5 g, preferably 0.1 g, 0.2 g, 0.3 g, 0.4 g, 0.5 g, 0.58 g, 0.6 g, 0.7 g, 0.8 g, 0.9 g, 1.0 g, 1.1 g, 1.2 g, 1.3 g, 1.4 g, 1.5 g or a range between the respective amounts, for example, 0.1-1.5 g, 0.1-1.4 g, 0.1-1.3 g, 0.1-1.2 g, 0.1-1.1 g 0.1-1.0g, 0.1-0.9g, 0.1-0.8g, 0.1-0.7g, 0.1-0.6g, 0.1-0.58g, 0.1-0.5g, 0.1-0.4g, 0.1-0.2g, 0.2-1.5g 0.2-1.4g, 0.2-1.3g, 0.2-1.2g, 0.2-1.1g, 0.2-1.0g, 0.2-0.9g, 0.2-0.8g, 0.2-0.7g, 0.2-0.6
  • the amount of the dye ie, a mixed dye selected from one or more of citrine, carmine, brilliant blue, CB-2, basic red 5, and acid yellow 2
  • the amount of the dye is 1-20 ml.
  • 11-14 ml more preferably 11 ml, 12 ml, 13 ml or 14 ml.
  • a process for the preparation of the above-mentioned combination product which comprises: preparing a dye using a polymer polysaccharide, petrolatum and a dye, wherein the polymer polysaccharide (prepared as an emulsifier) is selected from seaweed Sodium, chitosan, and combinations thereof, and a cationic polymer is used as the pretreatment liquid, wherein the cationic polymer is selected from the group consisting of polyethyleneimine, ⁇ -polylysine, and combinations thereof.
  • the method comprises: taking about 0.1-1.5 g of petrolatum (preferably 0.1 g, 0.2 g, 0.3 g, 0.4 g, 0.5 g, 0.58 g, 0.6 g, 0.7 g, 0.8 g, 0.9 g, 1.0 g) , 1.1 g, 1.2 g, 1.3 g, 1.4 g, 1.5 g or a range between the above amounts, for example, 0.2 to 1.4 g), sodium alginate or chitosan of about 0.1 to 1.2 g (preferably 0.1 g) , 0.2 g, 0.3 g, 0.35 g, 0.4 g, 0.5 g, 0.6 g, 0.7 g, 0.8 g, 0.9 g, 1.0 g, 1.1 g, 1.2 g or a range between the respective amounts, for example, 0.2- 1.1g), placed in a water bath at 50 ° C -90 ° C (preferably 60 ° C, 70 ° C or
  • a hair dyeing method using the above-described combination product comprising: spraying the hair with the pretreatment liquid, drying it after about 5 minutes; and then uniformly applying the dye to the dye On the treated hair, after about 10-15 minutes, a film is formed on the surface of the hair to complete the dyeing.
  • the invention has the advantages that the dyeing hair has low toxicity, excellent dyeing fastness and high washing durability.
  • Example 1 Effect of different pretreatment solutions on hair dyeing effect of yak hair
  • a treatment liquid for preparing a polyethyleneimine i.e., IP in Fig. 1) (molecular weight: 800), ⁇ -polylysine (i.e., PLL in Fig. 1) (molecular weight: 5000), or a combination thereof : Weigh 200mg of ⁇ -polylysine and polyethyleneimine, respectively, and add 1ml and 4ml of deionized water to prepare ⁇ -polylysine or polyethyleneimine solution with the desired concentration (labeled as 1 respectively) No. 2 and No. 2 pretreatment liquid), the concentration of the pretreatment liquid No. 1 was about 200 mg/ml, and the concentration of the No. 2 treatment liquid was 50 mg/ml.
  • the specific dyeing process is as follows: select the yak hair, apply the above-mentioned 6 sets of pretreatment liquid on the surface, and wipe off the surface pretreatment liquid after 5 minutes, evenly apply a layer of dye, dye for 10-15min, wash off After observation.
  • the purpose of this experiment was to treat the hair with different pretreatment liquids and observe the dyeing effect (the main indicator is the washfastness, that is, the color of the hair after washing with the rejuvenating shampoo), so as to determine further by the group of washing durability.
  • Pretreatment fluid used in the experiment was to treat the hair with different pretreatment liquids and observe the dyeing effect (the main indicator is the washfastness, that is, the color of the hair after washing with the rejuvenating shampoo), so as to determine further by the group of washing durability.
  • the pretreatment liquids of polyethyleneimine, poly- ⁇ -polylysine and polyethyleneimine/or ⁇ -polylysine can achieve the purpose of pretreatment (that is, the hair of different chromaticity can be obtained After treatment, it is very stained with black, and after 15 times of shampoo washing, its color does not completely fade, the washing degree is better, and the pretreatment liquid containing ⁇ -polylysine works best) Please refer to Figure 1.
  • Example 2 Effect of pretreatment solution containing ⁇ -polylysine on hair dyeing effect of yak hair
  • Specific hair dyeing process select yak hair, apply a layer of pretreatment liquid on the surface of yak hair, wipe off the residual treatment liquid after 5 minutes, apply a layer of dye, and dye for 15 minutes.
  • Example 3 Effect of pretreatment solution containing ⁇ -polylysine on the hair dyeing effect of white human hair (sample 1)
  • ⁇ -polylysine powder 400 mg was weighed and dissolved in 4 ml of deionized water to prepare a treatment liquid having a concentration of 100 mg/ml.
  • Hair dyeing process select white human hair, apply a layer of pretreatment liquid on the surface, wipe off the residual treatment liquid after 5 minutes, apply a layer of dye, and dye for 15 minutes.
  • the white human hair (sample 1) was dyed black, and as seen by the electron micrograph shown in Fig. 3, a film was formed on the surface of the white human hair to cover the surface of the hair, thereby contributing to a significant increase in the washfastness of the hair dye. .
  • Example 4 Effect of pretreatment solution containing ⁇ -polylysine on the hair dyeing effect of white human hair (sample 2)
  • ⁇ -polylysine powder 500 mg was weighed and dissolved in 6 ml of deionized water to prepare a treatment liquid having a concentration of 83.3 mg/ml.
  • Hair dyeing process select white human hair, apply a layer of pretreatment liquid on the surface, wipe off the residual treatment liquid after 5 minutes, apply a layer of dye, and dye for 15 minutes.
  • the white human hair (Sample 2) was dyed black, and as seen by the electron micrograph shown in Fig. 4, a film was formed on the surface of the white human hair to cover the surface of the hair, thereby contributing to a significant increase in the washfastness of the hair dye. .
  • Example 5 Effect of pretreatment solution containing ⁇ -polylysine on hair dyeing effect of yak hair after multiple washings
  • Hair dyeing process Select yak hair, apply a layer of pretreatment liquid on the surface, wipe off the residual treatment liquid after 5 minutes, apply a layer of dye, and dye for 15 minutes. Then wash with hair shampoo 5-15 times, blow dry with a hair dryer and observe.
  • the surface morphology of the dyed yak hair when washed with shampoo for different times shows that the surface is still covered by a film when washing 5-15 times, indicating that Hair fastness (or wash fastness) is excellent.
  • Example 6 Effect of pretreatment solution containing ⁇ -polylysine on hair coloring of different color hairs
  • 600 mg of ⁇ -polylysine powder was weighed and dissolved in 2 ml of deionized water to prepare a treatment liquid having a concentration of 300 mg/ml.
  • Hair dyeing process select hair from different sources (yellow, dark brown, grayish white and white flower from Guangzhou thin soft company), apply a layer of pretreatment liquid on it, wipe off the remaining surface treatment liquid after 5 minutes, apply one Layer paste, dyed for 15min.
  • the electron micrographs of different hairs before dyeing show that the hair dyeing method can be formed on the surface of the hair of different colors, and a film can be formed on the surface, thereby contributing to a significant increase in the washing durability.
  • the present invention effectively overcomes various shortcomings in the prior art and has high industrial utilization value.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

一种染发组合产品、制备和使用该组合产品的方法以及该组合产品用于染发的用途。所述染发组合产品包括预处理液和染膏，其中所述预处理液由阳离子聚合物组成；所述染膏包括聚合物多糖、凡士林以及染料或由它们组成；所述染料选自柠檬黄、胭脂红、亮蓝、CB-2、碱性红5、酸性黄2及其组合物。所述组合产品染色牢度高，多次洗发后颜色不易脱落且毒性小。

Description

[根据细则37.2由ISA制定的发明名称]　一种染发组合产品及其制备和使用方法 技术领域
本发明涉及一种含有预处理液和染膏的组合产品、制备和使用该组合产品的方法以及该组合产品用于染发的用途。
背景技术
头发最表层是表皮鳞，里面的是皮层细胞，头发中心部位的是毛髓。细胞中间的是互相粘合在一起的角蛋白。每一个细胞都顺着发茎形成角蛋白纤维素，纤维素中的斑点为黑色素颗粒。正是由他们形成了头发的颜色。目前市场上的无机染发剂主要是含铅、铁、铜等金属的化合物。染发剂中的金属离子渗透到头发中，与头发蛋白中的半胱氨酸中的硫作用，生成黑色硫化铅等，使用者头发被染黑。但无机染发剂中含有的重金属离子易引起蓄积中毒，对人体的危害很大，除有损头发健康易致过敏外，还可以引起多种疾病。铅易被人体吸收形成慢性中毒，慢性中毒初期感到疲倦、食欲不振等，发展时可能造成视力障碍和再生性贫血等疾病。铜被人体吸收，慢慢沉积过多会促进脂肪过氧化，从而引起动脉硬化和动脉纤维化等。其中，合成染发剂是对苯二胺使头发染成黑色，但是对苯二胺具有致癌性。而植物性染发剂是从天然植物中提取或以天然植物为原料制成的染发剂，但是其牢度不好，在染发后每次洗发时均会掉色。
因此，目前需要一种染色牢度高，多次洗发后颜色不易脱落且毒性小的染发产品。
发明内容
在本发明的第一方面，涉及一种组合产品，所述组合产品包括预处理液和染膏，或由预处理液和染膏组成。进一步地，其中所述预处理液包括阳离子聚合物或由其组成，且所述染膏由聚合物多糖、凡士林以及染料(选 自柠檬黄、胭脂红、亮蓝、CB-2、碱性红5和酸性黄2中的一种或它们中任意两种或更多种的组合物)组成。再进一步地，其中所述阳离子聚合物选自聚乙烯亚胺、ε-聚赖氨酸及其二者，且所述聚合物多糖选自海藻酸钠、壳聚糖及其二者。再进一步地，其中所述聚乙烯亚胺的浓度为1-400mg/ml，优选为50-150mg/ml、50-100mg/ml、100-150mg/ml，更优选为50mg/ml、100mg/ml或150mg/ml，且所述ε-聚赖氨酸的浓度为1-400mg/ml，优选为50-300mg/ml、50-200mg/ml、50-160mg/ml、50-133.3mg/ml、50-100mg/ml、50-83.3mg/ml、83.3-300mg/ml、83.3-200mg/ml、83.3-160mg/ml、83.3-133.3mg/ml、83.3-100mg/ml、100-300mg/ml、100-200mg/ml、100-160mg/ml、100-133.3mg/ml、133.3-300mg/ml、133.3-200mg/ml、133.3-160mg/ml、160-300mg/ml或160-200mg/ml，更优选为50mg/ml、83.3mg/ml、100mg/ml、133.3mg/ml、160mg/ml、200mg/ml或300mg/ml。再进一步地，所述海藻酸钠或壳聚糖的量为约0.1-1.2g，优选为0.1g、0.2g、0.3g、0.35g、0.4g、0.5g、0.6g、0.7g、0.8g、0.9g、1.0g、1.1g、1.2g或所述各量之间的范围，例如，0.2-1.1g。再进一步地，所述凡士林的量为0.1-1.5g，优选为0.1g、0.2g、0.3g、0.4g、0.5g、0.58g、0.6g、0.7g、0.8g、0.9g、1.0g、1.1g、1.2g、1.3g、1.4g、1.5g或所述各量之间的范围，例如，0.2-1.4g。还进一步地，所述染料(即，选自柠檬黄、胭脂红、亮蓝、CB-2、碱性红5和酸性黄2中的一种及其组合物)的量为1-20ml，优选11-14ml，更优选11ml、12ml、13ml或14ml。
在本发明的第二方面，涉及上述组合产品的制备方法，所述方法包括：使用聚合物多糖、凡士林以及染料制备染膏，其中所述聚合物多糖(作为乳化剂制备乳膏)选自海藻酸钠、壳聚糖及其组合物，且使用阳离子聚合物作为预处理液，其中所述阳离子聚合物选自聚乙烯亚胺、ε-聚赖氨酸及其组合物。进一步地，所述方法包括：取凡士林约0.1-1.5g(优选为0.1g、0.2g、0.3g、0.4g、0.5g、0.58g、0.6g、0.7g、0.8g、0.9g、1.0g、1.1g、1.2g、1.3g、1.4g、1.5g或所述各量之间的范围，例如，0.2-1.4g)，海藻酸钠或壳聚糖约0.1-1.2g(优选为0.1g、0.2g、0.3g、0.35g、0.4g、0.5g、0.6g、 0.7g、0.8g、0.9g、1.0g、1.1g、1.2g或所述各量之间的范围，例如，0.2-1.1g)，放置于50℃-90℃(优选60℃、70℃或80℃)的水浴锅中加热不断搅拌至熔融，不断搅拌下加入混合染料溶液，继续搅拌至完全乳化成膏状后停止加热，继续搅拌至室温；使用阳离子聚合物作为预处理液，其中所述阳离子聚合物选自聚乙烯亚胺、ε-聚赖氨酸及其组合物，其中所述聚乙烯亚胺的浓度为1-400mg/ml(优选为50-150mg/ml、50-100mg/ml、100-150mg/ml，更优选为50mg/ml、100mg/ml或150mg/ml)，所述ε-聚赖氨酸的浓度为1-400mg/ml(优选为50-300mg/ml、50-200mg/ml、50-160mg/ml、50-133.3mg/ml、50-100mg/ml、50-83.3mg/ml、83.3-300mg/ml、83.3-200mg/ml、83.3-160mg/ml、83.3-133.3mg/ml、83.3-100mg/ml、100-300mg/ml、100-200mg/ml、100-160mg/ml、100-133.3mg/ml、133.3-300mg/ml、133.3-200mg/ml、133.3-160mg/ml、160-300mg/ml或160-200mg/ml，更优选为50mg/ml、83.3mg/ml、100mg/ml、133.3mg/ml、160mg/ml、200mg/ml或300mg/ml)，且所述染料(即，选自柠檬黄、胭脂红、亮蓝、CB-2、碱性红5和酸性黄2中的一种或多种的混合染料)的量为1-20ml，优选11-14ml，更优选11ml、12ml、13ml或14ml。
在本发明的第三方面，涉及使用上述组合产品的染发方法，所述方法包括：使用所述预处理液对毛发进行喷洒处理，约5分钟后擦干；然后将所述染膏均匀涂抹在处理后的毛发上，约10-15分钟后使得毛发表面形成一层膜，完成染发。
在本发明的第四方面，涉及上述组合产品用于染发的用途。
附图说明
图1：不同的预处理液对牦牛毛发的染发效果的影响。
图2：通过电镜显示，含有ε-聚赖氨酸的预处理液对牦牛毛发的染发效果的影响。
图3：通过电镜显示，含有ε-聚赖氨酸的预处理液对白色的人毛发(样本1)的染发效果的影响。
图4：通过电镜显示，含有ε-聚赖氨酸的预处理液对白色的人毛发(样本2)的染发效果的影响。
图5：通过电镜显示，多次洗涤后含有ε-聚赖氨酸的预处理液对牦牛毛发的染发效果的影响。
图6：通过电镜显示，含有ε-聚赖氨酸的预处理液对不同颜色毛发的染发效果的影响。
图7：本发明要求保护的组合产品所带来的有益效果的原理图，即通过在所述组合产品在毛发表面形成一层保护膜，带来耐洗度的显著增加。
发明详述
本发明的发明点在于：本发明的组合产品包括由阳离子聚合物组成的预处理液以及由聚合物多糖、凡士林以及染料(柠檬黄、胭脂红、亮蓝、CB-2、碱性红5和酸性黄2)组成的染膏，或由它们组成，在使用时首先用由阳离子聚合物组成的预处理液先处理毛发，然后在毛发表面涂抹由聚合物多糖、凡士林以及染料组成的染膏，它们通过强静电吸附力吸附染料分子，并在毛发表面成膜，这不仅减小染发的毒性，而且增加了染色牢度。
定义
如本文使用的，术语“发”和“毛发”是指任何含角蛋白的纤维或纤维材料，包括任何人类的毛发、动物毛发(包括但不限于，兔毛、牦牛毛)和毛笔毛。
如本文所使用的，术语“颜料”是白色、黑色或有色的粉末状水溶性或非水溶性物质，其用于使得含有该颜料组合物着色和/或变得不透明。
如本文使用的，染发牢度(或耐洗度)是指颜色经受各种因素的作用而在不同程度上保持其原来色泽的能力，即抗色变的能力。染发牢度(或耐洗度)高是指颜色的抗色变能力高。在本文中，染发牢度(或耐洗度)主要通过多次洗涤(例如，15-20次)后，毛发上的颜色仍在不同程度上保持其原来的色泽没有褪去来反映。
如本文使用的，术语“室温”是指25℃±1℃。同时，若没有具体指明 实验温度，均为室温。
如本文所使用的，术语“约”是指该术语所修饰的数值的±20％，优选为±10％，更优选为±5％，因此本领域的普通技术人员能够清楚地根据所修饰的数值确定术语“约”的范围。
在本发明的第一方面，涉及一种组合产品，所述组合产品包括预处理液和染膏，或由预处理液和染膏组成。进一步地，其中所述预处理液包括阳离子聚合物或由其组成，且所述染膏包括聚合物多糖、凡士林以及染料(选自柠檬黄、胭脂红、亮蓝、CB-2、碱性红5和酸性黄2中的一种或多种的混合染料)，或由它们组成。再进一步地，其中所述阳离子聚合物选自聚乙烯亚胺、ε-聚赖氨酸及其组合物，且所述聚合物多糖选自海藻酸钠、壳聚糖及其组合物。再进一步地，其中所述聚乙烯亚胺的浓度1-400mg/ml，优选为50-150mg/ml、50-100mg/ml、100-150mg/ml，更优选为50mg/ml、100mg/ml或150mg/ml，且所述ε-聚赖氨酸的浓度为1-400mg/ml，优选为50-300mg/ml、50-200mg/ml、50-160mg/ml、50-133.3mg/ml、50-100mg/ml、50-83.3mg/ml、83.3-300mg/ml、83.3-200mg/ml、83.3-160mg/ml、83.3-133.3mg/ml、83.3-100mg/ml、100-300mg/ml、100-200mg/ml、100-160mg/ml、100-133.3mg/ml、133.3-300mg/ml、133.3-200mg/ml、133.3-160mg/ml、160-300mg/ml或160-200mg/ml，更优选为50mg/ml、83.3mg/ml、100mg/ml、133.3mg/ml、160mg/ml、200mg/ml或300mg/ml。再进一步地，所述海藻酸钠或壳聚糖的量为约0.1-1.2g，优选为0.1g、0.2g、0.3g、0.35g、0.4g、0.5g、0.6g、0.7g、0.8g、0.9g、1.0g、1.1g、1.2g或所述各量之间的范围，例如，0.1-1.1g、0.1-1.0g、0.1-0.9g、0.1-0.8g、0.1-0.7g、0.1-0.6g、0.1-0.5g、0.1-0.4g、0.1-0.35g、0.1-0.2g、0.2-1.2g、0.2-1.1g、0.2-1.0g、0.2-0.9g、0.2-0.8g、0.2-0.7g、0.2-0.6g、0.2-0.5g、0.2-0.4g、0.2-0.35g、0.2-0.3g、0.3-1.2g、0.3-1.1g、0.3-1.0g、0.3-0.9g、0.3-0.8g、0.3-0.7g、0.3-0.6g、0.3-0.5g、0.3-0.4g、0.3-0.35g、0.4-1.2g、0.4-1.1g、0.4-1.0g、0.4-0.9g、0.4-0.8g、0.4-0.7g、0.4-0.6g、0.4-0.5g、0.5-1.2g、0.5-1.1g、0.5-1.0g、0.5-0.9g、0.5-0.8g、0.5-0.7g、0.5-0.6g、0.6-1.2g、0.6-1.1g、0.6-1.0g、0.6-0.9g、0.6-0.8g、0.6-0.7g、0.7-1.2g、 0.7-1.1g、0.7-1.0g、0.7-0.9g、0.7-0.8g、0.8-1.2g、0.8-1.1g、0.8-1.0g、0.8-0.9g、0.9-1.2g、0.9-1.1g、0.9-1.0g、1.0-1.1g、1.0-1.2g或1.1-1.2g。再进一步地，所述凡士林的量为0.1-1.5g，优选为0.1g、0.2g、0.3g、0.4g、0.5g、0.58g、0.6g、0.7g、0.8g、0.9g、1.0g、1.1g、1.2g、1.3g、1.4g、1.5g或所述各量之间的范围，例如，0.1-1.5g、0.1-1.4g、0.1-1.3g、0.1-1.2g、0.1-1.1g、0.1-1.0g、0.1-0.9g、0.1-0.8g、0.1-0.7g、0.1-0.6g、0.1-0.58g、0.1-0.5g、0.1-0.4g、0.1-0.2g、0.2-1.5g、0.2-1.4g、0.2-1.3g、0.2-1.2g、0.2-1.1g、0.2-1.0g、0.2-0.9g、0.2-0.8g、0.2-0.7g、0.2-0.6g、0.2-0.58g、0.2-0.5g、0.2-0.4g、0.2-0.3g、0.3-1.5g、0.3-1.4g、0.3-1.3g、0.3-1.2g、0.3-1.1g、0.3-1.0g、0.3-0.9g、0.3-0.8g、0.3-0.7g、0.3-0.6g、0.3-0.58g、0.3-0.5g、0.3-0.4g、0.4-1.5g、0.4-1.4g、0.4-1.3g、0.4-1.2g、0.4-1.1g、0.4-1.0g、0.4-0.9g、0.4-0.8g、0.4-0.7g、0.4-0.6g、0.4-0.58g、0.4-0.5g、0.5-1.5g、0.5-1.4g、0.5-1.3g、0.5-1.2g、0.5-1.1g、0.5-1.0g、0.5-0.9g、0.5-0.8g、0.5-0.7g、0.5-0.6g、0.5-0.58g、0.58g-0.15g、0.58g-0.14g、0.58g-0.13g、0.58g-0.12g、0.58g-0.11g、0.58g-0.10g、0.58g-0.9g、0.58g-0.8g、0.58g-0.7g、0.58g-0.6g、0.6-1.5g、0.6-1.4g、0.6-1.3g、0.6-1.2g、0.6-1.1g、0.6-1.0g、0.6-0.9g、0.6-0.8g、0.6-0.7g、0.7-1.5g、0.7-1.4g、0.7-1.3g、0.7-1.2g、0.7-1.1g、0.7-1.0g、0.7-0.9g、0.7-0.8g、0.8-1.5g、0.8-1.4g、0.8-1.3g、0.8-1.2g、0.8-1.1g、0.8-1.0g、0.8-0.9g、0.9-1.5g、0.9-14g、0.9-1.3g、0.9-1.2g、0.9-1.1g、0.9-1.0g、1.0-1.5g、1.0-1.4g、1.0-1.3g、1.0-1.2g、1.0-1.1g、1.1-1.5g、1.1-1.4g、1.1-1.3g、1.1-1.2g、1.2-1.5g、1.2-1.4g、1.2-1.3g、1.3-1.5g、1.3-1.4g、1.4-1.5g。还进一步地，所述染料(即，选自柠檬黄、胭脂红、亮蓝、CB-2、碱性红5和酸性黄2中的一种或多种的混合染料)的量为1-20ml，优选11-14ml，更优选11ml、12ml、13ml或14ml。
在本发明的第二方面，涉及上述组合产品的制备方法，所述方法包括：使用聚合物多糖、凡士林以及染料制备染膏，其中所述聚合物多糖(作为乳化剂制备乳膏)选自海藻酸钠、壳聚糖及其组合物，且使用阳离子聚合物作为预处理液，其中所述阳离子聚合物选自聚乙烯亚胺、ε-聚赖氨酸及其组合物。进一步地，所述方法包括：取凡士林约0.1-1.5g(优选为0.1g、 0.2g、0.3g、0.4g、0.5g、0.58g、0.6g、0.7g、0.8g、0.9g、1.0g、1.1g、1.2g、1.3g、1.4g、1.5g或所述各量之间的范围，例如，0.2-1.4g)，海藻酸钠或壳聚糖约0.1-1.2g(优选为0.1g、0.2g、0.3g、0.35g、0.4g、0.5g、0.6g、0.7g、0.8g、0.9g、1.0g、1.1g、1.2g或所述各量之间的范围，例如，0.2-1.1g)，放置于50℃-90℃(优选60℃、70℃或80℃)的水浴锅中加热不断搅拌至熔融，不断搅拌下加入混合染料溶液，继续搅拌至完全乳化成膏状后停止加热，继续搅拌至室温；使用阳离子聚合物作为预处理液，其中所述阳离子聚合物选自聚乙烯亚胺、ε-聚赖氨酸及其组合物，其中所述聚乙烯亚胺的浓度为1-400mg/ml(优选为50-150mg/ml、50-100mg/ml、100-150mg/ml，更优选为50mg/ml、100mg/ml或150mg/ml)，所述ε-聚赖氨酸的浓度为1-400mg/ml(优选为50-300mg/ml、50-200mg/ml、50-160mg/ml、50-133.3mg/ml、50-100mg/ml、50-83.3mg/ml、83.3-300mg/ml、83.3-200mg/ml、83.3-160mg/ml、83.3-133.3mg/ml、83.3-100mg/ml、100-300mg/ml、100-200mg/ml、100-160mg/ml、100-133.3mg/ml、133.3-300mg/ml、133.3-200mg/ml、133.3-160mg/ml、160-300mg/ml或160-200mg/ml，更优选为50mg/ml、83.3mg/ml、100mg/ml、133.3mg/ml、160mg/ml、200mg/ml或300mg/ml)，且所述染料(即，选自柠檬黄、胭脂红、亮蓝、CB-2、碱性红5和酸性黄2中的一种或多种的混合染料)的量为1-20ml，优选11-14ml，更优选11ml、12ml、13ml或14ml。
在本发明的第三方面，涉及使用上述组合产品的染发方法，所述方法包括：使用所述预处理液对毛发进行喷洒处理，约5分钟后擦干；然后将所述染膏均匀涂抹在处理后的毛发上，约10-15分钟后使得毛发表面形成一层膜，完成染发。
在本发明的第四方面，涉及上述组合产品用于染发的用途。
本发明优点在于：染发的毒性低且染色牢度优良，耐洗度高。
具体实施方式
以下结合附图和具体实施例，对本发明作进一步说明。应理解，以下实 施例仅用于说明本发明而并非用于限定本发明权利要求中所涵盖的范围。
下述实施例中的方法，如无特殊说明，均采用常规方法。
实施例1：不同的预处理液对牦牛毛发的染发效果的影响
a.预处理液的配制
配制聚乙烯亚胺(即，图1中的IP)(分子量为800)、ε-聚赖氨酸(即，图1中的PLL)(分子量为5000)或它们二者的组合物的处理液：分别称取200mg的ε-聚赖氨酸和聚乙烯亚胺，分别加1ml和4ml去离子水配制成具有所需浓度的ε-聚赖氨酸或聚乙烯亚胺溶液(分别标记为1号和2号预处理液)，1号预处理液浓度约为200mg/ml，2号处理液的浓度为50mg/ml。
称取柠檬酸100mg，加2ml去离子水，配制成浓度为50mg/ml的溶液；取1ml浓氨水加9ml去离子水稀释；称取50mg的壳聚糖(即，图1中的CTS)加2.5ml的冰醋酸(2％)配制成浓度为20mg/ml的溶液。
然后按照要求，配制以下6组处理液:
(i)取2ml的1号预处理液(200mg/ml PLL)和0.5ml(50mg/ml IP800)的2号预处理液混合，得到第1组预处理液；
(ii)1ml柠檬酸(50mg/ml)与1号预处理液混合，得到第2组预处理液；
(iii)2ml柠檬酸(50mg/ml)与1号预处理液混合，得到第3组预处理液；
(iv)取1号处理液1ml(200mg/ml PLL)和25μl氨水(氨水与去离子水的比例为1：9)混合，得到第4组预处理液；
(v)取1号处理液1ml(200mg/ml PLL)，得到第5组预处理液；
(vi)取1号处理液1ml(200mg/ml PLL)和4ml CTS(20mg/ml)混合，得到第6组预处理液。
b.染膏的配制
配制染膏:取凡士林约1.2g，海藻酸钠约0.4g，置于100ml烧杯中，在60℃的水浴锅中加热不断搅拌至熔融，然后在不断搅拌下加入混合染料 15ml溶液，继续搅拌至完全乳化成膏状后停止加热，继续搅拌至室温。
c.染发过程
具体染发过程如下：选择牦牛毛发，在其表面涂抹分别涂覆上述配制的6组预处理液，5min后擦去表面残留的预处理液，均匀涂抹一层染膏，染色10-15min，洗掉后观察。
d.结果
本实验的目的是，使用不同预处理液处理毛发，观察染色效果(主要指标为耐洗度，即，使用飘柔洗发水洗后观看毛发的颜色)，从而通过耐洗度的组别确定进一步实验所使用的预处理液。
试验中发现，聚乙烯亚胺、聚ε-聚赖氨酸及聚乙烯亚胺/或ε-聚赖氨酸的预处理液均能够达到预处理目的(即，能够让不同色度的毛发在处理后，很好的染上黑色，并经15次的洗发水洗后，其颜色没有完全褪去，耐洗度较好，且以含ε-聚赖氨酸的预处理液效果最好)，请参考图1。
实施例2：含有ε-聚赖氨酸的预处理液对牦牛毛发的染发效果的影响
a.预处理液的制备，具体步骤如下:
称取300mgε-聚赖氨酸粉末溶于6ml的去离子水中，浓度为50mg/ml的处理液。
b.染膏的制备，具体步骤如下:
称取凡士林约0.8g，海藻酸钠约0.7g，于100ml烧杯中，放置于70℃的水浴锅中加热不断搅拌至熔融，然后在不断搅拌下加入CB-2、碱性红5和酸性黄2的混合染料溶液12ml，继续搅拌至完全乳化成膏状后停止加热，继续搅拌至室温。
c.具体染发过程：选择牦牛毛发，在其牦牛毛表面涂抹一层预处理液，5min后擦去表面残留的处理液，涂抹一层染膏，染15min。
d.结果
使用SEM对头发表面在放大倍数为3000的条件下进行扫描观察得图2，发现在染后的白牦牛毛表面形成一层膜覆盖在头发表面，从而有利于 染发耐洗度的显著增加。
实施例3：含有ε-聚赖氨酸的预处理液对白色的人毛发(样本1)的染发效果的影响
a.预处理液的制备，具体步骤如下:
称取400mg的ε-聚赖氨酸粉末，溶于4ml的去离子水中，配制成浓度为100mg/ml的处理液。
b.染膏的制备，具体步骤如下:
称取凡士林约0.6g，海藻酸钠约0.4g，于100ml烧杯中，放置于80℃的水浴锅中加热不断搅拌至熔融，然后在不断搅拌下加入CB-2、碱性红5和酸性黄2混合染料溶液10ml，继续搅拌至完全乳化成膏状后停止加热，继续搅拌至室温。
c.染发过程：选择白色的人毛发，在其表面涂抹一层预处理液，5min后擦去表面残留的处理液，涂抹一层染膏，染15min。
d.结果
将白色的人毛发(样本1)染成黑色，且由图3所示的电镜图看到，在白色的人毛发表面形成一层膜覆盖在头发表面，从而有利于染发耐洗度的显著增加。
实施例4：含有ε-聚赖氨酸的预处理液对白色的人毛发(样本2)的染发效果的影响
a.预处理液的制备，具体步骤如下:
称取500mg的ε-聚赖氨酸粉末，溶于6ml的去离子水中，配制成浓度为83.3mg/ml的处理液。
b.染膏的制备，具体步骤如下:
称取凡士林约0.9g，海藻酸钠约0.3g，于100ml烧杯中，放置于60℃的水浴锅中加热不断搅拌至熔融，然后在不断搅拌下加入CB-2、碱性红5和酸性黄2混合染料溶液13ml，继续搅拌至完全乳化成膏状后停止加热， 继续搅拌至室温。
c.染发过程：选择白色的人毛发，在其表面涂抹一层预处理液，5min后擦去表面残留的处理液，涂抹一层染膏，染15min。
d.结果
将白色的人毛发(样本2)染成黑色，且由图4所示的电镜图看到，在白色的人毛发表面形成一层膜覆盖在头发表面，从而有利于染发耐洗度的显著增加。
实施例5：多次洗涤后，含有ε-聚赖氨酸的预处理液对牦牛毛发的染发效果的影响
a.预处理液的制备，具体步骤如下:
称取800mg的ε-聚赖氨酸溶于6ml的去离子水中，制成浓度为133.3mg/ml的处理液。
b.染膏的制备，具体步骤如下:
称取凡士林约0.58g，海藻酸钠约0.35g，于100ml烧杯中，放置于90℃的水浴锅中加热不断搅拌至熔融，然后在不断搅拌下加入柠檬黄、胭脂红、亮蓝混合染料溶液11ml，继续搅拌至完全乳化成膏状后停止加热，继续搅拌至室温。
c.染发过程：选择牦牛毛发，在其表面涂抹一层预处理液，5min后擦去表面残留的处理液，涂抹一层染膏，染15min。然后用洗发水洗5-15次，用吹风机吹干后观察。
d.结果
如图5所示，根据电镜图显示，被染牦牛毛发在用洗发水洗不同次数时其表面的形貌，显示在洗5-15次时，其表面仍由一层膜所覆盖，说明其染发牢度(或耐洗度)极佳。
实施例6含有ε-聚赖氨酸的预处理液对不同颜色毛发的染发效果的影响
a.预处理液的制备，具体步骤如下:
称取600mg的ε-聚赖氨酸粉末，溶于2ml的去离子水中，配制成浓度为300mg/ml的处理液。
b.染膏的制备，具体步骤如下:
称取凡士林约1.1g，海藻酸钠约0.5g，于100ml烧杯中，放置于70℃的水浴锅中加热不断搅拌至熔融，然后在不断搅拌下加入柠檬黄、胭脂红、亮蓝混合染料溶液14ml，继续搅拌至完全乳化成膏状后停止加热，继续搅拌至室温。
c.染发过程：选择不同来源的毛发(广州薄柔公司赠送的黄色、黑褐色、灰白及花白色)，在其上涂抹一层预处理液，5min后擦去表面残留的处理液，涂抹一层染膏，染15min。
d.结果
如图6所示，不同毛发在染前的电镜图，其表明在不同颜色人毛发上使用该方法染发，均能在表面形成一层膜，从而有利于染发耐洗度的显著增加。
综上所述，本发明有效克服了现有技术中的种种缺点而具高度产业利用价值。
上述实施例仅例示性说明本发明的原理及其功效，而非用于限制本发明。任何熟悉此技术的人士皆可在不违背本发明的精神及范畴下，对上述实施例进行修饰或改变。因此，在所属技术领域中具有通常知识者在未脱离本发明所揭示的精神与技术思想下所完成的一切等效修饰或改变，仍应由本发明的权利要求所涵盖。

Claims (9)

  1. 组合产品，所述组合产品包括预处理液和染膏，其中所述预处理液由阳离子聚合物组成，且所述染膏包括聚合物多糖、凡士林以及染料或由它们组成，所述染料选自柠檬黄、胭脂红、亮蓝、CB-2、碱性红5、酸性黄2及其组合物。
  2. 根据权利要求1的组合产品，其中所述阳离子聚合物选自聚乙烯亚胺、ε-聚赖氨酸及其组合物，且所述聚合物多糖选自海藻酸钠、壳聚糖及其组合物。
  3. 根据权利要求2的组合产品，其中所述聚乙烯亚胺的浓度为1-400mg/ml，优选为50-150mg/ml、50-100mg/ml、100-150mg/ml，更优选为50mg/ml、100mg/ml或150mg/ml，且所述ε-聚赖氨酸的浓度为1-400mg/ml，优选为50-300mg/ml、50-200mg/ml、50-160mg/ml、50-133.3mg/ml、50-100mg/ml、50-83.3mg/ml、83.3-300mg/ml、83.3-200mg/ml、83.3-160mg/ml、83.3-133.3mg/ml、83.3-100mg/ml、100-300mg/ml、100-200mg/ml、100-160mg/ml、100-133.3mg/ml、133.3-300mg/ml、133.3-200mg/ml、133.3-160mg/ml、160-300mg/ml或160-200mg/ml，更优选为50mg/ml、83.3mg/ml、100mg/ml、133.3mg/ml、160mg/ml、200mg/ml或300mg/ml。
  4. 根据权利要求2的组合产品，其中所述海藻酸钠或壳聚糖的量为约0.1-1.2g，优选为0.1g、0.2g、0.3g、0.35g、0.4g、0.5g、0.6g、0.7g、0.8g、0.9g、1.0g、1.1g、1.2g或所述各量之间的范围。
  5. 根据权利要求1-4中任一项的组合产品的制备方法，所述方法包括：使用聚合物多糖、凡士林以及染料制备染膏，其中所述聚合物多糖选自海藻酸钠、壳聚糖及其组合物，且使用阳离子聚合物作为预处理液，其中所 述阳离子聚合物选自聚乙烯亚胺、ε-聚赖氨酸及其组合物。
  6. 根据权利要求5的制备方法，所述方法包括：取凡士林约0.1-1.5g、海藻酸钠或壳聚糖约0.1-1.2g，放置于50℃-90℃，优选60℃、70℃或80℃的水浴锅中加热不断搅拌至熔融，不断搅拌下加入混合染料溶液，继续搅拌至完全乳化成膏状后停止加热，继续搅拌至室温；且其中所述聚乙烯亚胺的浓度为1-400mg/ml(优选为50-150mg/ml、50-100mg/ml、100-150mg/ml，更优选为50mg/ml、100mg/ml或150mg/ml)，所述ε-聚赖氨酸的浓度为1-400mg/ml(优选为50-300mg/ml、50-200mg/ml、50-160mg/ml、50-133.3mg/ml、50-100mg/ml、50-83.3mg/ml、83.3-300mg/ml、83.3-200mg/ml、83.3-160mg/ml、83.3-133.3mg/ml、83.3-100mg/ml、100-300mg/ml、100-200mg/ml、100-160mg/ml、100-133.3mg/ml、133.3-300mg/ml、133.3-200mg/ml、133.3-160mg/ml、160-300mg/ml或160-200mg/ml，更优选为50mg/ml、83.3mg/ml、100mg/ml、133.3mg/ml、160mg/ml、200mg/ml或300mg/ml)。
  7. 根据权利要求6的制备方法，其中所述凡士林为0.1g、0.2g、0.3g、0.4g、0.5g、0.58g、0.6g、0.7g、0.8g、0.9g、1.0g、1.1g、1.2g、1.3g、1.4g、1.5g或所述各量之间的范围，且所述海藻酸钠或壳聚糖为0.1g、0.2g、0.3g、0.35g、0.4g、0.5g、0.6g、0.7g、0.8g、0.9g、1.0g、1.1g、1.2g或所述各量之间的范围。
  8. 使用根据权利要求1-4中任一项的组合产品的染发方法，所述方法包括：使用所述预处理液对毛发进行喷洒处理，约5分钟后擦干；然后将所述染膏均匀涂抹在处理后的毛发上，约10-15分钟后使得毛发表面形成一层膜，完成染发。
  9. 根据权利要求1-4中任一项的组合产品用于染发的用途。
PCT/CN2018/106533 2017-09-28 2018-09-19 一种染发组合产品及其制备和使用方法 WO2019062623A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201710895797.X 2017-09-28
CN201710895797.XA CN109568177A (zh) 2017-09-28 2017-09-28 一种组合产品及其使用和制备方法

Publications (1)

Publication Number Publication Date
WO2019062623A1 true WO2019062623A1 (zh) 2019-04-04

Family

ID=65902224

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2018/106533 WO2019062623A1 (zh) 2017-09-28 2018-09-19 一种染发组合产品及其制备和使用方法

Country Status (2)

Country Link
CN (1) CN109568177A (zh)
WO (1) WO2019062623A1 (zh)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1424061A1 (fr) * 2002-11-29 2004-06-02 L'oreal Procédé de traitement cosmétique capillaire conférant aux cheveux des propriétés cosmétiques durables
EP1600148A1 (fr) * 2004-05-28 2005-11-30 L'oreal Composition pour la coloration des fibres kératiniques comprenant un composé portant au moins une fonction amine, un pigment et un agent de couplage chimique
EP1600149A1 (fr) * 2004-05-28 2005-11-30 L'oreal Composition pour la coloration des fibres kératiniques comprenant un pigment et des polymères aptes à réagir l'un avec l'autre pour former des liaisons covalentes
US20090070945A1 (en) * 2007-09-14 2009-03-19 L'oreal Method of coloring hair
CN102892433A (zh) * 2010-04-01 2013-01-23 医疗技术转换控股有限公司 染色组合物
CN103429220A (zh) * 2011-03-10 2013-12-04 荷兰联合利华有限公司 组合物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2833487B1 (fr) * 2001-12-18 2004-08-27 Oreal Compositions cosmetiques comprenant des polymeres a fonctions chimiques complementaires
US20050273947A1 (en) * 2004-05-28 2005-12-15 Gaelle Brun Composition for dyeing keratin fibers comprising at least one compound bearing at least one amine function, at least one pigment and at least one chemical coupling agent
EP3067041B1 (en) * 2013-10-17 2019-12-04 Shisei Chemical Co., Ltd. Method for dyeing keratin fibers, keratin fiber dye
JP6323899B2 (ja) * 2013-10-17 2018-05-16 資生ケミカル株式会社 ケラチン繊維の染色方法及びケラチン繊維用染色剤
EP3015135B1 (en) * 2014-10-29 2020-09-09 Noxell Corporation Hair colouration with a cationic or anionic coloured polymer, method and kit thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1424061A1 (fr) * 2002-11-29 2004-06-02 L'oreal Procédé de traitement cosmétique capillaire conférant aux cheveux des propriétés cosmétiques durables
EP1600148A1 (fr) * 2004-05-28 2005-11-30 L'oreal Composition pour la coloration des fibres kératiniques comprenant un composé portant au moins une fonction amine, un pigment et un agent de couplage chimique
EP1600149A1 (fr) * 2004-05-28 2005-11-30 L'oreal Composition pour la coloration des fibres kératiniques comprenant un pigment et des polymères aptes à réagir l'un avec l'autre pour former des liaisons covalentes
US20090070945A1 (en) * 2007-09-14 2009-03-19 L'oreal Method of coloring hair
CN102892433A (zh) * 2010-04-01 2013-01-23 医疗技术转换控股有限公司 染色组合物
CN103429220A (zh) * 2011-03-10 2013-12-04 荷兰联合利华有限公司 组合物

Also Published As

Publication number Publication date
CN109568177A (zh) 2019-04-05

Similar Documents

Publication Publication Date Title
CN109846742A (zh) 一种多色无毒染发剂及其制备方法和染发方法
CN108030704A (zh) 以氧化石墨烯为助染剂的植物染发剂及制备方法
CN101431976A (zh) 用于角蛋白纤维染色的组合物及使用其染发的方法
US20190216712A1 (en) Hair dye composition, preparation method, and application method thereof
CN109394558B (zh) 一种仿黑色素无毒染发剂的制备及染发的方法
CN108603042A (zh) 纤维素基有机颜料
CN108451780A (zh) 一种耐洗染发剂及其制备方法
TW201223551A (en) Hair dye containing one or multiple edible pigments or cosmetic pigments and hair dyeing method using the same
JPH01249713A (ja) 毛髪染色剤
KR101734043B1 (ko) 폴리도파민 및 금속염을 유효성분으로 함유하는 염모제용 조성물
WO2019062623A1 (zh) 一种染发组合产品及其制备和使用方法
CN110184832A (zh) 一种针织涤纶弹力布的染色工艺
CN102821747A (zh) 选择性处理皮肤的方法和组合物
JPS60152408A (ja) 染毛剤組成物
CN104083307A (zh) 采用植物色素红花色素制备的一种天然染发剂及其染发方法
CN111329805A (zh) 新型天然茜草石墨烯染发剂的制备方法
JP2000143683A (ja) タンニン類の鉄化合物
JP2008280321A (ja) 染毛料及びその製造方法
JPS62174005A (ja) カラ−表示付き酸化染毛組成物
JPS6233113A (ja) 染毛剤
JP3905167B2 (ja) 薬草による連続染色法
KR20170124337A (ko) 코치닐 추출물을 이용한 천연가죽의 염색방법
JP2012246284A (ja) 染毛料
CN114028253B (zh) 基于黑色素和花青素的彩色染发剂及制备方法、使用方法
TWI771134B (zh) 天然染髮劑及其商品化配方

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 18861254

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

32PN Ep: public notification in the ep bulletin as address of the adressee cannot be established

Free format text: NOTING OF LOSS OF RIGHTS PURSUANT TO RULE 112(1) EPC (EPO FORM 1205A DATED 23.07.2020)

122 Ep: pct application non-entry in european phase

Ref document number: 18861254

Country of ref document: EP

Kind code of ref document: A1