WO2019046287A1 - COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HEPATITIS B - Google Patents

COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HEPATITIS B Download PDF

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Publication number
WO2019046287A1
WO2019046287A1 PCT/US2018/048320 US2018048320W WO2019046287A1 WO 2019046287 A1 WO2019046287 A1 WO 2019046287A1 US 2018048320 W US2018048320 W US 2018048320W WO 2019046287 A1 WO2019046287 A1 WO 2019046287A1
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WO
WIPO (PCT)
Prior art keywords
benzamide
phenyl
fluoro
inhibitor
chloro
Prior art date
Application number
PCT/US2018/048320
Other languages
English (en)
French (fr)
Inventor
Michael J. Sofia
Ting CHIU
Aaron Timothy ELEY
Original Assignee
Arbutus Biopharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arbutus Biopharma Corporation filed Critical Arbutus Biopharma Corporation
Publication of WO2019046287A1 publication Critical patent/WO2019046287A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
PCT/US2018/048320 2017-08-30 2018-08-28 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HEPATITIS B WO2019046287A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762551969P 2017-08-30 2017-08-30
US62/551,969 2017-08-30

Publications (1)

Publication Number Publication Date
WO2019046287A1 true WO2019046287A1 (en) 2019-03-07

Family

ID=65526021

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2018/048320 WO2019046287A1 (en) 2017-08-30 2018-08-28 COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING HEPATITIS B

Country Status (2)

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TW (1) TW201912153A (zh)
WO (1) WO2019046287A1 (zh)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111349056A (zh) * 2020-04-16 2020-06-30 南京安纳康生物科技有限公司 用于乙型肝炎病毒感染的抗病毒剂
CN111393391A (zh) * 2020-04-16 2020-07-10 南京安纳康生物科技有限公司 用于乙型肝炎病毒感染的抗病毒剂
WO2020221811A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel oxalyl piperazines active against the hepatitis b virus (hbv)
WO2020221824A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv)
WO2020221816A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv)
WO2020221826A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indole-2-carboxamides active against the hepatitis b virus (hbv)
CN113264917A (zh) * 2021-05-28 2021-08-17 华南理工大学 一种抗乙肝病毒化合物及其制备方法和应用
CN115677545A (zh) * 2022-10-28 2023-02-03 潍坊医学院 一种抗hbv磺胺苯甲酰胺类衍生物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110021464A1 (en) * 2008-01-25 2011-01-27 Ernest Randall Lanier Methods of treating viral infections
WO2014106019A2 (en) * 2012-12-27 2014-07-03 Philadelphia Health & Education Corporation, D/B/A Drexel Novel antiviral agents against hbv infection
US20140206666A1 (en) * 2011-07-01 2014-07-24 Philadelphia Helath & Education Corporation d/b/a Drexel University College of Medicine Sulfamoylbenzamide derivatives as antiviral agents against hbv infection

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110021464A1 (en) * 2008-01-25 2011-01-27 Ernest Randall Lanier Methods of treating viral infections
US20140206666A1 (en) * 2011-07-01 2014-07-24 Philadelphia Helath & Education Corporation d/b/a Drexel University College of Medicine Sulfamoylbenzamide derivatives as antiviral agents against hbv infection
WO2014106019A2 (en) * 2012-12-27 2014-07-03 Philadelphia Health & Education Corporation, D/B/A Drexel Novel antiviral agents against hbv infection

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020221811A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel oxalyl piperazines active against the hepatitis b virus (hbv)
WO2020221824A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indolizine-2-carboxamides active against the hepatitis b virus (hbv)
WO2020221816A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel phenyl and pyridyl ureas active against the hepatitis b virus (hbv)
WO2020221826A1 (en) 2019-04-30 2020-11-05 Aicuris Gmbh & Co. Kg Novel indole-2-carboxamides active against the hepatitis b virus (hbv)
CN111349056A (zh) * 2020-04-16 2020-06-30 南京安纳康生物科技有限公司 用于乙型肝炎病毒感染的抗病毒剂
CN111393391A (zh) * 2020-04-16 2020-07-10 南京安纳康生物科技有限公司 用于乙型肝炎病毒感染的抗病毒剂
CN111393391B (zh) * 2020-04-16 2022-07-26 南京安纳康生物科技有限公司 用于乙型肝炎病毒感染的抗病毒剂
CN111349056B (zh) * 2020-04-16 2022-08-02 南京安纳康生物科技有限公司 用于乙型肝炎病毒感染的抗病毒剂
CN113264917A (zh) * 2021-05-28 2021-08-17 华南理工大学 一种抗乙肝病毒化合物及其制备方法和应用
CN115677545A (zh) * 2022-10-28 2023-02-03 潍坊医学院 一种抗hbv磺胺苯甲酰胺类衍生物及其制备方法和应用
CN115677545B (zh) * 2022-10-28 2024-03-15 潍坊医学院 一种抗hbv磺胺苯甲酰胺类衍生物及其制备方法和应用

Also Published As

Publication number Publication date
TW201912153A (zh) 2019-04-01

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