WO2019036047A1 - Filtre concentrique pour la crosse de l'aorte et méthodes d'utilisation de ce dernier - Google Patents

Filtre concentrique pour la crosse de l'aorte et méthodes d'utilisation de ce dernier Download PDF

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Publication number
WO2019036047A1
WO2019036047A1 PCT/US2018/000343 US2018000343W WO2019036047A1 WO 2019036047 A1 WO2019036047 A1 WO 2019036047A1 US 2018000343 W US2018000343 W US 2018000343W WO 2019036047 A1 WO2019036047 A1 WO 2019036047A1
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WO
WIPO (PCT)
Prior art keywords
catheter
filter
catheter system
expanded position
lumen
Prior art date
Application number
PCT/US2018/000343
Other languages
English (en)
Inventor
Thomas HALDIS
Alexander DROFA
Original Assignee
Sanford Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanford Health filed Critical Sanford Health
Publication of WO2019036047A1 publication Critical patent/WO2019036047A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/01—Filters implantable into blood vessels
    • A61F2/013—Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063—Three-dimensional shapes
    • A61F2230/0067—Three-dimensional shapes conical

Definitions

  • Cardiovascular surgery has traditionally been performed with open surgical techniques that involve invasive procedures to surgically excise the diseased structure before sewing in an artificial replacement often requiring prolonged clamping to halt blood flow through the diseased segment.
  • open surgical techniques are effective and durable but they can only be performed on relatively healthy patients and often result in relatively long recovery periods.
  • minimally invasive techniques have been developed and used with endovascular or catheter-directed methodologies. These minimally invasive approaches can make the procedures more broadly applicable to patients with more comorbidities. It can also reduce recovery times and reduce the risk of certain complications.
  • minimally invasive techniques can create a new set of complications that need to be dealt with. For instance, embolus formation is one such example.
  • thrombus buildup In several diseased states the cardiovascular system may develop thrombus buildup.
  • One area where thrombus buildup is troublesome is the aortic arch. Atheroma in the aortic arch can be a nidus for clot. If blood flow from the heart is not hemodynamically normal it can result in thrombus deposition in the arch. Alternatively, thrombus deposition in the arch could be caused by aneurysmal dilation which causes slower than normal velocities as well as regions along the curvature of the bulge where recirculating zones and stagnation develop which lead to further thrombus formation.
  • calcified deposits can form on the leaflets of the native aortic valve. Then, when a large structural heart prosthetic such as an aortic valve is deployed, the prosthetic can knock calcified particles off of the native aortic valve leaflets. If these break free they form emboli which can also travel distally including into the great vessels.
  • emboli form in the aortic arch or the aortic valve, this can be especially problematic as the emboli will travel distally causing complications in the bloodstream.
  • emboli having a diameter of less than 100 micrometers are less problematic.
  • Emboli having a diameter greater than 100 micrometers should be trapped in a filtration system.
  • TAVR transcatheter aortic valve replacement
  • Non-paradoxic stroke as a result from transcatheter aortic valve implantation can be traced to aortic atheroma, valve debris, air or ventricular or atrial, aortic or valvular thrombus.
  • Atheroma can be scraped and carried proximal to the great vessels from descending aortic arch segments. Atheroma can be dislodged during valve transit around the arch and embolize primarily.
  • Valve debris can be dislodged during valve crossing or during valve deployment.
  • Air can be introduced into the aorta from the TAVI system or from balloon rupture.
  • Ventricular thrombus can be dislodged with wire in the left ventricle.
  • Atrial appendage thrombus can be dislodged during rapid pacing. After TAVR, thrombus can form in situ in the aorta or on the valve stent or leaflets leading to a later event. In fact, many strokes occur after all of the TAVR equipment has been removed when a patient is recovering.
  • a TAVR In a TAVR, the catheter is brought from a groin access, through the aorta, over the arch, and into the native valve before deployment. The large size of the valve on the stent necessitates a catheter having a larger diameter. Finally, in an ascending aortic aneurysm or dissection a stent graft is brought again from the same approach. The stent graft is then deployed above the sinotubular junction and below the braciocephalic artery. Again, this is a relatively large stent graft necessitating a large catheter being advanced up and over the aortic arch potentially breaking loose thrombus thereby forming dangerous emboli.
  • a catheter system including (a) a first catheter having a first end and a second end, the first catheter defining a first lumen, (b) a second catheter having a first end and a second end, the second catheter defining a second lumen, wherein the first catheter is positioned at least partially within the second lumen of the second catheter, and wherein the second catheter and the first catheter and moveable with respect to each other, and (c) a filter having a first end and a second end such that the first end of the filter is coupled to the first catheter, wherein the filter comprises an expandable frame and a semipermeable membrane coupled to the expandable frame, and wherein the expandable frame has shape memory and is movable from a compressed position to an expanded position in response to the second catheter being retracted relative to the first catheter and/or the first catheter being advanced relative to the second catheter.
  • a method in a second aspect, includes: (a) introducing a guidewire into an arterial configuration via arterial access, (b) loading the catheter system according to the first aspect onto the guidewire, (c) advancing the catheter system along the guidewire into the arterial configuration, and (d) retracting the second catheter relative to the first catheter thereby permitting the filter to transition from the compressed position to the expanded position.
  • Figure 1A is a perspective view of a catheter system in a compressed position, according to an example embodiment.
  • Figure IB is a perspective view of the catheter system of Figure 1A in an expanded position, according to an example embodiment.
  • Figure 2 is a perspective view of the catheter system of Figure 1 A in an expanded position in an aortic arch, according to an example embodiment.
  • Figure 3 is a perspective view of an example catheter system, according to an example embodiment.
  • Figure 4 is a perspective view of another example catheter system, according to an example embodiment.
  • Figure 5 is a perspective view of another example catheter system, according to an example embodiment.
  • Figure 6 is a flow chart depicting functions that can be carried out in accordance with example embodiments of the disclosed methods.
  • Coupled means associated directly, as well as indirectly.
  • a member A may be directly associated with a member B, or may be indirectly associated therewith, e.g., via another member C. It will be understood that not all relationships among the various disclosed elements are necessarily represented.
  • ⁇ "second" item does not require or preclude the existence of, e.g., a "first" or lower-numbered item, and/or, e.g., a "third" or higher-numbered item.
  • apparatus, element and method “configured to” perform a specified function is indeed capable of performing the specified function without any alteration, rather than merely having potential to perform the specified function after further modification.
  • the apparatus, element, and method “configured to” perform a specified function is specifically selected, created, implemented, utilized, programmed, and/or designed for the purpose of performing the specified function.
  • “configured to” denotes existing characteristics of an apparatus, element, and method which enable the apparatus, element, and method to perform the specified function without further modification.
  • an apparatus, element, and method described as being “configured to” perform a particular function may additionally or alternatively be described as being “adapted to” and/or as being “operative to” perform that function.
  • a "catheter” is an apparatus that is connected to a deployment mechanism and is configured to house a prosthetic device that can be delivered over a guidewire.
  • the catheter may include a guidewire lumen for over-the-wire guidance and may be used for delivering the medical device to a target lumen.
  • a "guidewire” is an elongated cable comprised of one or more biocompatible materials including metals and polymers. Guidewires may be used for selecting target lumens and guiding catheters to target deployment locations. Guidewires are typically definecj as wires used independently of other devices that do not come as part of an assembly.
  • a “stent” is a device that is advanced through emboli or a clot in the form of an occlusion and configured to expand and embed in the clot. Once embedded in the occlusion, the stent may then be retracted to restore blood flow and aid thrombectomy in acute embolic stroke.
  • target vessel refers to the blood vessel or artery in which the apparatus is deployed.
  • the target vessel may further include artificial lumens used, for example, as teaching aids.
  • the "filter” reters to a material that may effectively permit blood flow through the filter but prevent particles having a diameter greater than about 100 micrometers from passing therethrough.
  • the "frame” refers to a structure capable of having shape memory that comprises a bio-compatible material.
  • a “membrane” is a thin pliable sheet of material.
  • lumen refers to a passage within an arterial or tubular structure, such as the pulmonary arteries or a passage within the tubular housings or catheters through which the guidewire may be disposed.
  • first end refers to a proximal end of the device or component thereof
  • second end refers to a distal end of the device or component thereof.
  • distal with respect to a portion of the apparatus means the end of the device (when in use) nearer the treatment zone (e.g., the pulmonary artery) of the subject and the term “proximal” means the portion of the device (when in use) further away from the targeted lumen of the subject and nearer the access site and the operator.
  • proximal means the portion of the device (when in use) further away from the targeted lumen of the subject and nearer the access site and the operator.
  • cerebral embolic protection may be helpful. To perform this procedure, a guidewire would first be advanced via a femoral access through the iliac artery and aorta, and over the aortic arch.
  • the catheter carrying the filter device would be advanced over the guidewire and positioned within the aortic arch.
  • the radiopaque marker on the catheter may aid in positioning.
  • the second catheter can be retracted relative to the first catheter and/or the first catheter can be advanced relative to the second catheter until the filter is deployed. If the filter is not positioned properly along the axis of the aorta, the operator can advance the second catheter to recapture, reposition, and redeploy the filter.
  • a prosthetic device i.e., aortic valve or stent graft
  • a prosthetic device can be deployed via balloon inflation through the first catheter or by releasing a self- expanding prosthetic device via movement of the first catheter relative to a third catheter, as discussed in detail below.
  • the prosthetic device can be a part of the first catheter.
  • the prosthetic device can be a separate device which is brought through the first catheter after the filter is deployed.
  • the filter can be removed. First the second catheter is re-advanced retracting the first catheter back into the second catheter, thereby trapping the embolic particles contained within the filter. Once the filter and any ensuing emboli are in the first catheter and second catheter, the emboli can be removed along with the first catheter and the second catheter from the body.
  • Figures 1A-1B illustrate a catheter system 100 according to an example embodiment.
  • the catheter system 100 includes a first catheter 102 having a first end 104 and a second end 106 opposite the first end 104.
  • the first catheter 102 defines a first lumen 108.
  • the catheter system 100 also includes a second catheter 110 having a first end 112 and a second end 114 opposite the first end 112.
  • the second catheter 110 defines a second lumen 116.
  • the first catheter 102 is positioned at least partially within the second lumen 116 of the second catheter 110.
  • the second catheter 110 and the first catheter 102 are moveable with respect to each other.
  • the catheter system 100 also includes a filter 118 having a first end 120 and a second end 122 such that the first end 120 of the filter 118 is coupled to the first catheter 102.
  • the filter 118 comprises an expandable frame 124 and a semipermeable membrane 126 coupled to the expandable frame 124.
  • the expandable frame 124 has shape memory and is movable from a compressed position (as seen in Figure 1A) to an expanded position (as seen in Figure IB) in response to the second catheter 1 10 being retracted relative to the first catheter 102 and/or the first catheter 102 being advanced relative to the second catheter 110.
  • the first end 120 of the filter 118 may be coupled to the first catheter 102 at a distance proximal to the second end 106 of the first catheter 102, as shown in Figure IB.
  • a longitudinal axis of the first lumen 108 may be parallel to a longitudinal axis of the second lumen 116, as shown in Figure 1A.
  • the second end 106 of first catheter 102 and the second end 114 of the second catheter 1 10 may each include a radio-opaque marker 128, 130.
  • one or more of the first catheter 102, the second catheter 110, and the expandable frame 124 may include a hydrophilic coating.
  • the second end 122 of the filter 118 is coupled to the first catheter 102 at the second end 106 of the first catheter 102. Such a coupling may be in place of or in addition to the coupling of the first end 120 of the filter 118 to the first catheter 102.
  • the second end 122 of the filter 1 18 may include one or more struts 131 extending from the second end 122 of the filter 1 18 to the exterior surface 140 of the first catheter 102.
  • the one or more struts 131 may have shape memory to move from the compressed position to the expanded position.
  • the one or more struts 131 may provide an outward force to radially bias the expandable frame 124 in the expanded position such that the second end 122 of the filter 1 18 is configured to conform to a lumen 132 of a target vessel 134 in the expanded position, as shown in Figure 2.
  • the expandable frame 124 itself provides the outward force such that the expandable frame is radially biased outward in the expanded position without the need for the one or more struts 131.
  • the expandable frame 124 may be coupled to the semipermeable membrane 126 along a perimeter of the second end 122 of the filter 1 18.
  • the expandable frame 124 has a cone-shape in the expanded position such that the second end 122 has a larger diameter than the first end 120.
  • the tapered first end 120 of the filter 1 18 permits the expandable frame 124 and the filter 1 18 to form an outward expanding cone- shape at the first end 120 to capture emboli in the filter 1 18 when the filter 1 18 is advanced back into the first catheter 102.
  • This capability may beneficially capture particles that break away from the filter during re-sheathing of the cone-shaped second end 122 of the filter 1 18 into the second lumen 116 of the second catheter 1 10.
  • the expandable frame 124 has an elongated sleeve shape in the expanded position.
  • the expandable frame 124 and filter 1 18 may taper slightly from the second end 122 that is free to the first end 120 that is coupled to the first catheter 102.
  • the semipermeable membrane 126 should be of sufficient porosity to capture particles that are large enough to create dangerous levels of ischemia.
  • the semipermeable membrane 126 is configured to prevent the passage therethrough of particles having a diameter greater than about 100 ⁇ .
  • the semipermeable membrane 126 may include a polyethylene terephthalate (PET) knit fabric, dacron, polyester, polycaprolactone, polyethylene, polypropylene, polyvinylchloride, polyethersulfone, polylactide, polyglycolide, polyethersulfone, polyetrafluoroethylene, polyetheretherketone, polysulfone, polypropylene and combinations thereof.
  • PET polyethylene terephthalate
  • a length of the filter 1 18 from the first end 120 to the second end 122 may range from about 10 mm to about 500 mm.
  • a diameter of the second end 122 of the filter 1 18 in the expanded position may range from about 5 mm to about 100 mm.
  • the filter 1 18 may have a thickness ranging from about 0.001 mm to about 0.5 mm.
  • the semipermeable membrane 126 may include a plurality of shape memory wires.
  • shape memory wires may comprise nitinol, titanium, titanium alloys, or copper-aluminum-nickel alloys as examples.
  • the shape memory wires may be woven together in a cross-hatch pattern to form the semipermeable membrane 126.
  • the semipermeable membrane 126 further includes a filter media having the plurality of shape memory wires disposed therein, and the filter media is porous, cross-hatched or multi-layered.
  • the plurality of shape memory wires are curved radially outward to bias the expandable frame 124 to the expanded position.
  • the first catheter 102 has an outer diameter 136
  • the second catheter 1 10 has an inner diameter 138 that is greater than the outer diameter 136 of the first catheter 102.
  • the outer diameter 136 of the first catheter 102 ranges from about 0.5 mm to about 3 mm.
  • the inner diameter 138 of the second catheter 1 10 ranges from about 0.5 mm to about 8 mm.
  • the filter 1 18 may be positioned at least partially between an exterior surface 140 of the first catheter 102 and an interior surface 142 of the second catheter 1 10 in the compressed position, as shown in Figure 1A.
  • the first catheter 102 may have a first outer diameter 144 for a first portion 145 of the first catheter 102, and the first catheter 102 may have a second outer diameter 146 for a second portion 147 of the first catheter 102.
  • the first outer diameter 144 is greater than the second outer diameter 146.
  • the outer diameter of the first catheter 102 is reduced in the area in which the filter 118 is positioned prior to deployment.
  • the first catheter 102 may have a third outer diameter ⁇ 48 for a third portion 149 of the first catheter 102, where the second portion 147 is positioned between the first portion 145 and the third portion 149.
  • the third outer diameter 148 may be equal to the first outer diameter 144.
  • the catheter system 100 may further include a third catheter 150 having a first end 152 and a second end 154 opposite the first end 152.
  • the third catheter 150 is positioned at least partially within the first lumen 108 of the first catheter 102, and the third catheter 150, the second catheter 1 10, and the first catheter 102 are with respect to each other. The movement of the third catheter 150 with respect to the first catheter 102 may thereby unsheath a self-expanding stent valve 158.
  • the outer diameter of the third catheter 150 ranges from about 0.5 mm to about 2 mm, for example.
  • the third catheter 150 upon which the self-expanding stent valve 158 is mounted may be a wire or a catheter.
  • the third catheter 150 may include mounting brackets 162 for the self-expanding stent valve 158.
  • the filter 1 18 may be detachable from the first catheter 102 via a coupling mechanism 164.
  • the coupling mechanism 164 may take a variety of forms.
  • the coupling mechanism 164 may include male and female mating threads. The male and female portions of the mating threads may be made from a bio-compatible metal such as titanium, nitinol or a hard bio-compatible polymer, as examples.
  • the first catheter 102 can be twisted in order to detach the first catheter 102 from the filter 1 18.
  • the coupling mechanism 164 may include a releasable pull cord within the first catheter 102.
  • the coupling mechanism 164 may include wiring configured to impart an electric charge to a coupling between the second end 122 of the filter 1 18 and the first catheter 102.
  • the coupling mechanism 164 may include an inflatable balloon configured to fracture the connection between the first catheter 102 and the filter 118 upon inflation.
  • Other example coupling mechanisms are possible as well.
  • the first end 120 of the filter 1 18 may include one or more snarable features 168, which may be snared by a guidewire from the descending aorta to remove the filter 1 18 from the target vessel after completion of a procedure.
  • Other snarable features 170 can be added to the second end 122 of the filter 118, thereby enabling the operator to pull on a snare wire effectively bending the second end 122 of the filter 1 18 in the direction of the first end 120 of the filter 1 18 while the first end 120 of the filter 1 18 is at least partially positioned within the first lumen 108 of the first catheter 102, thereby trapping the emboli in the filter 118 for safe removal from the patient.
  • the filter 1 18 may be detached from the first catheter 102 via the coupling mechanism 164 and left in the target vessel to continue filtering after a procedure is completed.
  • the filter 1 18 may be dissolved or be absorbed by a patient's body after a period of in vivo exposure.
  • the catheter system 100 may include a second coupling mechanism 174 positioned between the second end 122 of the filter 1 18 and an implanted prosthetic device 172, such as a valve as shown in Figure 5.
  • the second coupling mechanism 174 may comprise any of the examples of the coupling mechanism described above.
  • the operator has the option of detaching the connection of the implanted prosthetic device 172 via the second coupling mechanism 174 to detach the implanted prosthetic device 172, or detaching the filter 1 18 from the first catheter 102 via the coupling mechanism 164 to leave the filter 1 18 and/or the implanted medical prosthetic device 172 permanently in vivo.
  • Figure 6 is a simplified flow chart illustrating a method 200 according to an exemplary embodiment. Although the blocks are illustrated in a sequential order, these blocks may also be performed in parallel, and/or in a different order than those described herein. Also, the various blocks may be combined into fewer blocks, divided into additional blocks, and/or removed based upon the desired implementation.
  • the method 200 involves introducing a guidewire 176 into an arterial configuration via arterial access.
  • the method 200 includes loading the catheter system 100 according to any one of the embodiments described above onto the guidewire 176.
  • the method 200 includes advancing the catheter system 100 along the guidewire 176 into the arterial configuration.
  • the method 200 includes retracting the second catheter 110 relative to the first catheter 102 thereby permitting the filter 118 to transition from the compressed position to the expanded position.
  • the first catheter 102 advanced relative to the second catheter
  • the method 200 may further include conforming the second end 122 of expandable frame 124 of the filter 118 to the arterial configuration in which the filter 1 18 is deployed. In another embodiment, the method 200 may further include advancing a prosthetic device 172 coupled to the first catheter 102 to a position distal to the second end 122 of the filter 118.
  • the prosthetic device 172 comprises a stent mounted on the first catheter 102.
  • the prosthetic device 172 comprises a valve mounted on the first catheter 102, such as a self-expanding stent valve 158. Other prosthetic device 172 are possible as well.
  • the method 200 may further include capturing at least one particle on the semipermeable membrane 126 of the filter 118.
  • the at least one particle includes embolic material.
  • the method 200 may further include advancing the second catheter 1 10 toward the second end 122 of the filter 1 18 and thereby transitioning the filter 118 from the expanded position to the compressed position in which the filter 1 18 is positioned within the second lumen 116 of the second catheter 1 10.
  • the method 200 may further include retaining at least one particle between an exterior surface 140 of the first catheter 102 and the semipermeable membrane 126 of the filter 1 18.
  • the arterial configuration is an aortic arch
  • the method 200 may further include positioning the second end 106 of the first catheter 102 proximal to the innominate artery prior to retracting the second catheter 110.
  • the method 200 may further include advancing the third catheter 150 relative to the first catheter 102, thereby permitting a self-expanding stent valve 158 coupled to the third catheter 150 to transition from a compressed position to an expanded position.
  • the method 200 may further include detaching the first end 120 of the filter 1 18 from the first catheter 102.
  • the method 200 may further include snaring the second end 122 of the filter 1 18 via a snarable feature 170 coupled to the second end 122 of the filter 1 18, and pulling the second end 122 of the filter 1 18 towards the first end 120 of the filter 1 18 while the first end 120 of the filter 118 is at least partially positioned within the first lumen 108 of the first catheter 102.
  • the second end 122 of the filter 1 18 can be snared and pulled toward the first catheter 102, thereby pulling the second end 122 of the filter 1 18 in the direction of the first end 120 of the filter 1 18, essentially trapping the embolic material in the filter 1 18 prior to safely removing from the patient.

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  • Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Prostheses (AREA)

Abstract

La présente invention concerne un système de cathéter comprenant : (a) un premier cathéter comprenant une première extrémité et une seconde extrémité, le premier cathéter définissant une première lumière, (b) un second cathéter possédant une première extrémité et une seconde extrémité, le second cathéter définissant une seconde lumière, le premier cathéter étant positionné au moins partiellement à l'intérieur de la seconde lumière du second cathéter, et le second cathéter et le premier cathéter étant mobiles l'un par rapport à l'autre, et (c) un filtre couplé au premier cathéter, le filtre comprenant un cadre extensible et une membrane semi-perméable couplée au cadre extensible, et le cadre extensible ayant une mémoire de forme et pouvant passer d'une position comprimée à une position déployée en réponse au recul du second cathéter par rapport au premier cathéter et/ou à l'avancement du premier cathéter par rapport au second cathéter.
PCT/US2018/000343 2017-08-18 2018-08-20 Filtre concentrique pour la crosse de l'aorte et méthodes d'utilisation de ce dernier WO2019036047A1 (fr)

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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001067989A2 (fr) * 2000-03-10 2001-09-20 Don Michael T Anthony Dispositif de prevention d"embolie vasculaire utilisant des filtres
US20020002383A1 (en) * 2000-06-29 2002-01-03 Ivan Sepetka Systems, methods and devices for removing obstructions from a blood vessel
US20020138094A1 (en) * 1999-02-12 2002-09-26 Thomas Borillo Vascular filter system
US20130178891A1 (en) * 2012-01-06 2013-07-11 Emboline, Inc. Integrated embolic protection devices
WO2015184450A1 (fr) * 2014-05-30 2015-12-03 Cardiac Valve Solutions Llc Valve temporaire et filtre sur cathéter de guidage

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020138094A1 (en) * 1999-02-12 2002-09-26 Thomas Borillo Vascular filter system
WO2001067989A2 (fr) * 2000-03-10 2001-09-20 Don Michael T Anthony Dispositif de prevention d"embolie vasculaire utilisant des filtres
US20020002383A1 (en) * 2000-06-29 2002-01-03 Ivan Sepetka Systems, methods and devices for removing obstructions from a blood vessel
US20130178891A1 (en) * 2012-01-06 2013-07-11 Emboline, Inc. Integrated embolic protection devices
WO2015184450A1 (fr) * 2014-05-30 2015-12-03 Cardiac Valve Solutions Llc Valve temporaire et filtre sur cathéter de guidage

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