WO2019031807A3 - 플라즈모닉 효과를 이용한 질병의 진단 방법 및 질병 진단용 슬라이드 - Google Patents

플라즈모닉 효과를 이용한 질병의 진단 방법 및 질병 진단용 슬라이드 Download PDF

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Publication number
WO2019031807A3
WO2019031807A3 PCT/KR2018/008949 KR2018008949W WO2019031807A3 WO 2019031807 A3 WO2019031807 A3 WO 2019031807A3 KR 2018008949 W KR2018008949 W KR 2018008949W WO 2019031807 A3 WO2019031807 A3 WO 2019031807A3
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WIPO (PCT)
Prior art keywords
disease
diagnosing
slide
diagnosing disease
raman scattering
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PCT/KR2018/008949
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English (en)
French (fr)
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WO2019031807A2 (ko
Inventor
정두련
이규성
강민희
주재범
이상엽
황준기
이세희
Original Assignee
사회복지법인 삼성생명공익재단
한양대학교 에리카산학협력단
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Publication of WO2019031807A2 publication Critical patent/WO2019031807A2/ko
Publication of WO2019031807A3 publication Critical patent/WO2019031807A3/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/65—Raman scattering
    • G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G01N2333/29—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Richettsiales (o)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

본 발명은 플라즈모닉 효과를 이용한 질병의 진단 방법 및 질병 진단용 슬라이드에 관한 것으로서, 본 발명의 일 실시예에 따른 질병의 진단 방법은 플라즈모닉 나노 구조가 형성된 진단용 슬라이드의 웰(well) 상에 항원액을 점적(drip)하는 단계, 웰 상에 간접면역형광항체법(indirect immunofluorescence antibody)을 이용하여 표면증강라만산란 신호를 생성하는 단계, 생성된 표면증강라만산란 신호를 항체의 역가에 따라 측정하는 단계 및 측정된 표면증강라만산란 신호를 분석하여 질병의 양성 또는 음성인지 여부를 판정하는 단계를 포함하는 것을 특징으로 한다.
PCT/KR2018/008949 2017-08-08 2018-08-07 플라즈모닉 효과를 이용한 질병의 진단 방법 및 질병 진단용 슬라이드 WO2019031807A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170100555A KR102127146B1 (ko) 2017-08-08 2017-08-08 플라즈모닉 효과를 이용한 질병의 진단에 필요한 정보 제공 방법 및 질병 진단용 슬라이드
KR10-2017-0100555 2017-08-08

Publications (2)

Publication Number Publication Date
WO2019031807A2 WO2019031807A2 (ko) 2019-02-14
WO2019031807A3 true WO2019031807A3 (ko) 2019-05-09

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PCT/KR2018/008949 WO2019031807A2 (ko) 2017-08-08 2018-08-07 플라즈모닉 효과를 이용한 질병의 진단 방법 및 질병 진단용 슬라이드

Country Status (2)

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KR (1) KR102127146B1 (ko)
WO (1) WO2019031807A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102434781B1 (ko) * 2020-11-30 2022-08-22 한국과학기술원 초박형 하이드로젤 스킨 3d 플라즈모닉 복합 구조체
KR20230119901A (ko) * 2022-02-08 2023-08-16 재단법인 아산사회복지재단 머신 러닝 기반 라만 분광 분석을 이용한 염증 질환 분류 방법 및 장치

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010230679A (ja) * 1999-07-16 2010-10-14 William Marsh Rice Univ 生体感知用途のための金属微細シェル
KR20120087051A (ko) * 2011-01-27 2012-08-06 주식회사 사이언스앳홈 표면 증강 라만 산란 입자 및 광학 이미징 기술을 이용한 질병진단
US20130023435A1 (en) * 2009-12-22 2013-01-24 Agency For Science, Technology And Research Sers-based analyte detection
WO2013066986A1 (en) * 2011-10-31 2013-05-10 Puget Sound Blood Genter Antibody response phenotyping
KR20130095393A (ko) * 2012-02-20 2013-08-28 대한민국(관리부서 질병관리본부장) 간접면역형광항체법에 의한 레지오넬라증 진단용 항원슬라이드의 제조방법 및 이를 이용한 마이크로 다가 항원슬라이드

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010230679A (ja) * 1999-07-16 2010-10-14 William Marsh Rice Univ 生体感知用途のための金属微細シェル
US20130023435A1 (en) * 2009-12-22 2013-01-24 Agency For Science, Technology And Research Sers-based analyte detection
KR20120087051A (ko) * 2011-01-27 2012-08-06 주식회사 사이언스앳홈 표면 증강 라만 산란 입자 및 광학 이미징 기술을 이용한 질병진단
WO2013066986A1 (en) * 2011-10-31 2013-05-10 Puget Sound Blood Genter Antibody response phenotyping
KR20130095393A (ko) * 2012-02-20 2013-08-28 대한민국(관리부서 질병관리본부장) 간접면역형광항체법에 의한 레지오넬라증 진단용 항원슬라이드의 제조방법 및 이를 이용한 마이크로 다가 항원슬라이드

Also Published As

Publication number Publication date
KR102127146B1 (ko) 2020-06-26
WO2019031807A2 (ko) 2019-02-14
KR20190016387A (ko) 2019-02-18

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