WO2019022406A1

WO2019022406A1 - Hybrid continuous blood glucose measurement system

Info

Publication number: WO2019022406A1
Application number: PCT/KR2018/007634
Authority: WO
Inventors: 최규동
Original assignee: 최규동
Priority date: 2017-07-24
Filing date: 2018-07-05
Publication date: 2019-01-31
Also published as: KR20190010931A; KR101975198B1

Abstract

The present invention relates to a hybrid continuous blood glucose measurement system. The hybrid continuous blood glucose measurement system, which is worn by a user so as to continuously measure the blood glucose of the user, comprises: a body housing worn by the user; a blood glucose measurement sensor cartridge replaceably mounted in the body housing and having a continuous blood glucose measurement probe sensor and a plurality of corrected blood glucose probe sensors; a corrected blood glucose measurement driving unit for performing driving such that the plurality of corrected blood glucose probe sensors sequentially invade the user and return under the control of a main control unit; a blood glucose measurement unit correcting and measuring the blood glucose value measured by the continuous blood glucose measurement probe sensor according to the blood glucose values measured by the corrected blood glucose probe sensors, thereby transmitting the measured blood glucose value to the main control unit; and a user interface for displaying the blood glucose value received from the main control unit and receiving an operation input of the user.

Description

Hybrid Continuous Blood Glucose Monitoring System

The present invention relates to a hybrid continuous blood glucose measurement system, which comprises: a main body housing (110) worn by a user; A blood glucose measurement sensor cartridge 200 that is replaceably mounted on the main body housing 100 and includes a continuous blood glucose measurement probe sensor 210 and a plurality of corrected blood glucose probe sensors 221; And a corrected blood sugar level measurement driver (300) driven by the plurality of corrected blood glucose probe sensors (221) according to the control of the main controller (500) so as to sequentially invade and return to the user. And a blood glucose measurement unit that measures the blood glucose value measured by the continuous blood glucose level measurement probe sensor 210 in accordance with the blood glucose value measured by the corrected blood glucose probe sensor 221 and transmits the measured blood glucose value to the main control unit 500 (400); A user interface 800 for displaying the blood glucose value received from the main control unit 500 and receiving an operation input of the user; And a blood glucose measuring device for measuring blood glucose levels.

Diabetes is a disease that can be managed by controlling blood sugar levels. This disease management is usually managed by administering the amount of insulin injected according to the blood glucose level of the patient and administering insulin at predetermined time intervals. However, since the blood glucose level of each patient and the change of blood sugar according to insulin administration are different for each individual patient, there is a problem that it is difficult to accurately and efficiently determine the dosage and interval / interval of insulin administration.

This problem relies on closed-loop insulin delivery, which is possible using a continuous glucose monitoring (CGM) system that delivers a signal directly to the insulin tank.

However, existing enzyme sensors that collect blood at the fingertip limit the frequency of measurement and can not be used in such CGMs. Recently, an improved version of the enzyme sensor that can be attached to the body has been developed and is being provided in hospitals for continuous measurement of blood glucose for several days. However, there are some limitations to this method as well, which may require calibration several times a day and also consume body fluids, as well as discontinuous measurement at fixed time intervals.

In order to solve the problems of the present invention, Korean Patent No. 10-1512566 or Korean Patent No. 10-1454278 discloses a sensor capable of continuously monitoring the blood glucose level in the body, As a measurement sensor, it is based on a nanostructure for enhancing the sensitivity of a sensor, and includes a membrane structure in which a surface is selectively permeable to remove interference, and an electrochemical method capable of biocompatibility by means of improving biocompatibility A configuration relating to a continuous blood glucose monitoring sensor is disclosed.

However, since these conventional inventions also require calibration, it is necessary to accurately measure the calibration blood glucose separately or separately on a regular basis using a separate blood glucose measuring means (for example, a disposable blood glucose measuring apparatus) There has been a problem that it is necessary to cumbersome correction work by inputting blood glucose values separately.

In addition, there are secondary risk factors for diabetes patients, such as cardiovascular-related diseases such as tissue necrosis caused by occlusion of distal vessels, in addition to direct risk due to blood glucose fluctuation. Therefore, by measuring the heartbeat or oxygen saturation associated therewith, It was necessary to prepare in advance.

The present invention solves the above-mentioned problems of the prior art, and provides a hybrid continuous blood glucose measurement system capable of accurately calibrating a measurement value using self-calibration blood glucose measurement without using a separate calibration blood glucose measurement device, We will do it.

The present invention also provides a hybrid continuous blood glucose measurement system capable of preventing a problem such as inflammation or infection that may occur when a position for measuring calibration blood glucose is sequentially changed and operated so as to repeatedly invade the same affected part We do thing as problem.

It is another object of the present invention to provide a hybrid continuous blood glucose measurement system capable of measuring an oxygen saturation and a heart rate together with blood glucose to measure an indication of a cardiovascular related disease which is likely to occur in a diabetic patient.

Another object of the present invention is to provide a hybrid continuous blood glucose measurement system capable of detecting sleep apnea by additionally using a three-axis acceleration sensor in addition to heart rate and oxygen saturation measurement.

In order to achieve the above object, the hybrid continuous blood glucose measurement system (10) of the present invention comprises: a main body housing (110) worn by a user; A blood glucose measurement sensor cartridge 200 that is replaceably mounted on the main body housing 100 and includes a continuous blood glucose measurement probe sensor 210 and a plurality of corrected blood glucose probe sensors 221; And a corrected blood sugar level measurement driver (300) driven by the plurality of corrected blood glucose probe sensors (221) according to the control of the main controller (500) so as to sequentially invade and return to the user. And a blood glucose measurement unit that measures the blood glucose value measured by the continuous blood glucose level measurement probe sensor 210 in accordance with the blood glucose value measured by the corrected blood glucose probe sensor 221 and transmits the measured blood glucose value to the main control unit 500 (400); A user interface 800 for displaying the blood glucose value received from the main control unit 500 and receiving an operation input of the user; And a control unit.

In addition, the main body housing 110 includes a blood glucose measurement sensor cartridge mounting portion 101 on which the blood glucose measurement sensor cartridge 200 can be inserted and mounted; Wherein the blood glucose measurement sensor cartridge (200) is provided with the continuous blood glucose measurement probe sensor (210) at its center, and each of the corrected blood glucose probe sensors (221) The correction blood glucose level measurement driving unit 300 is installed on the bottom surface of the outer side of the measurement arm 220. The corrected blood glucose level measurement driving unit 300 is installed on the main body housing 110, A corrected glucose measurement drive magnet part 310 formed to be positioned respectively; A measurement arm driving unit 320 formed on the corrected blood sugar measuring arm 220 and configured to include a corrected blood glucose electromagnet coil pattern unit 321; Wherein the corrected blood glucose level measurement driving unit 300 includes a calibration blood glucose measurement sensor unit 310 for measuring the blood glucose level of the blood glucose measurement sensor, Only the arm driving part 320 is selectively driven to return after the invasive operation.

A cartridge guide 102 formed below the blood glucose measurement sensor cartridge mounting portion 101; A guide hole 230 formed in the blood glucose measurement sensor cartridge 200 to allow the blood glucose measurement sensor cartridge 200 to be mounted at an accurate mounting position with the cartridge guide 102 inserted therein; A continuous blood glucose measurement probe through hole 111 through which the continuous blood glucose measurement probe 210 can pass is formed at the center of the body housing 110, And a blood glucose measurement probe through hole 112 through which the blood glucose measurement sensor 221 can be inserted and through which the blood glucose measurement sensor cartridge 221 can be inserted, respectively, and a cartridge fixing support portion 113 capable of fixing and supporting the blood glucose measurement sensor cartridge 200, A replaceable cover 110 formed on the upper surface; And further comprising:

The corrected blood glucose electromagnet coil pattern portion 321 includes an upper surface pattern portion 322 formed on the upper surface of the measurement arm 320; And is formed so as to have a current rotation direction A 'that is the same as the current rotation direction A of the top surface pattern part 322 and is formed in the lower surface of the measurement arm 320 in parallel with the top surface pattern part 322 A pattern unit 323; And further comprising:

The oxygen saturation measuring sensor 620 provided on the lower surface of the main body housing 100 detects oxygen saturation through the measured value of the oxygen saturation measuring sensor 620 and detects oxygen saturation Saturation measuring unit 600; And further comprising:

The sleep apnea measurement unit 500 determines the sleep apnea state of the user through the movement of the user measured by the three-dimensional acceleration sensor 710 installed in the main housing 100, (700); And further comprising:

A communication interface 900 for transmitting the measurement value including the blood glucose value received from the main control unit 500 to the user terminal 1; And further comprising:

It is an object of the present invention to solve the problems of the prior arts described above, and it is an advantage that the measurement value can be accurately corrected by measuring the calibration blood glucose value itself without using a separate calibration blood glucose measurement device.

In addition, it has an advantage that it is possible to prevent problems such as inflammation and infection that may occur when repeatedly inflating the same affected part repeatedly by sequentially changing the position for measuring the correcting blood glucose.

On the other hand, by measuring oxygen saturation and heart rate together with blood glucose, it is possible to measure the signs of cardiovascular-related diseases that are likely to occur in diabetics.

In addition to the measurement of heart rate and oxygen saturation, there is an advantage that it is possible to detect sleep apnea by additionally using a three-axis acceleration sensor.

1 is a view showing a configuration of a hybrid continuous blood glucose measurement system according to an embodiment of the present invention;

2 is a block diagram showing a configuration of a hybrid continuous blood glucose measurement system according to an embodiment of the present invention;

Fig. 3 is a diagram showing a corrected blood glucose measurement operation of the hybrid continuous blood glucose measurement system according to one embodiment of the present invention.

Fig. 4 is a diagram showing a front configuration of a measurement arm of a hybrid continuous blood glucose measurement system according to an embodiment of the present invention; Fig.

5 is a view showing a rear configuration of a measurement arm of a hybrid continuous blood glucose measurement system according to an embodiment of the present invention.

6 is a view showing a rear configuration of a measurement arm of a hybrid continuous blood glucose measurement system according to another embodiment of the present invention.

Description of reference numerals used in drawings

S: skin

1: User terminal

10: Hybrid continuous blood glucose measurement system

100: main body housing 101: blood glucose measurement sensor cartridge mounting part

102: cartridge guide

110: Replacement cover 111: Continuous blood glucose measurement probe penetration

112: Calibration blood glucose measurement probe penetration

113: cartridge fixing support

200: blood glucose measurement sensor cartridge

210: Continuous blood glucose measurement probe sensor

211a and 211b: continuous blood glucose signal transfer electrodes

220: Calibrating blood glucose measuring arm

221: Calibration blood glucose measurement probe sensor

222a and 222b: a corrected blood sugar signal transfer electrode

230: Guide hole

300: corrected blood glucose measurement driving part

310: Calibrating glucose meter drive electronics

320:

321: corrected blood glucose electromagnet coil pattern part

322: upper

surface pattern part

323, 323 &

325a, 325b: corrected blood sugar electromagnet driving electrode

400: blood glucose measuring unit

500: main control unit

600: oxygen saturation measuring unit

610: Oxygen saturation measurement module

620: Oxygen saturation measurement sensor

621: oxygen saturation light emitting unit 622: oxygen saturation light receiving unit

700: sleep apnea measuring part

710: 3D acceleration sensor

800: User Interface

810: Display 820: Operation input means

900: Communication interface

Hereinafter, a hybrid continuous blood glucose measurement system according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings. First, it should be noted that, in the drawings, the same components or parts are denoted by the same reference numerals whenever possible. In describing the present invention, a detailed description of known functions and configurations incorporated herein will be omitted so as to avoid obscuring the subject matter of the present invention.

1 and 2, the hybrid continuous blood glucose measurement system 10 according to the present invention includes a main body housing 110, a blood glucose measurement sensor cartridge 200, a corrected blood glucose measurement drive unit 300, a blood glucose measurement unit 400 A main control unit 500, and a user interface 800. [0033] FIG.

First, the main housing 110 will be described. The main body housing 110 is configured to be worn or attached to the user's body such as the abdomen. In this case, the main body housing 110 may have a separate wearing means or attaching means such as a band or an adhesive patch so that the user can wear or attach the body.

As shown in FIG. 1, the main body housing 100 may further include a blood glucose measurement sensor cartridge mounting portion 101 on which the blood glucose measurement sensor cartridge 200 can be inserted. In this case, as shown in Fig. 3, the blood glucose measurement sensor cartridge mounting portion 101 is configured such that the blood glucose measurement sensor cartridge mounting portion 101 is attached to the blood glucose measurement sensor cartridge mounting portion 101 as shown in Fig. 3 (A) or (C) It is preferable that the corrected blood glucose probe 221 is formed at a depth not to be exposed from the lower surface of the main housing 100. [

1, a cartridge guide 102 is formed on the lower side of the blood glucose measurement sensor cartridge mounting portion 101 so that the cartridge guide 102 is mounted at the correct mounting position every time the cartridge 200 is replaced It is desirable to make it possible to do so.

Next, the blood glucose measurement sensor cartridge 200 will be described. 1, the blood glucose measurement sensor cartridge 200 is replaceably mounted on the main body housing 100 and includes a continuous blood glucose measurement probe sensor 210 and a plurality of corrected blood glucose probe sensors 221 .

In this case, the continuous blood glucose measurement probe 210 is continuously infiltrated into the user's skin S while the user wears or attaches the body housing 100 as shown in FIG. 3, Of the blood glucose level.

On the other hand, as described later, the corrected blood glucose probe 221 measures the blood glucose by temporarily invading the skin S of the user only at a predetermined time interval (for example, every two hours) And returns to the user's skin (S) again.

The embodiments implementing the blood glucose measurement sensor cartridge 200 can be implemented in various embodiments. 1 and 4, the blood glucose measurement sensor cartridge 200 is provided with the continuous blood glucose measurement probe sensor 210 in the center, and each of the corrected blood glucose probe sensors 221 Are preferably provided on the lower end of the outer side of the radially formed corrected blood glucose measurement arm 220, respectively.

As shown in FIG. 1, the blood glucose measurement sensor cartridge 200 is provided with a plurality of sensors (not shown) for detecting the presence or absence of the blood glucose measurement sensor cartridge 200, It is preferable that a guide hole 230 for inserting the blood glucose measurement sensor cartridge 200 into the correct mounting position is formed with the guide 102 inserted therein.

Meanwhile, the continuous blood glucose measurement probe 210 and the corrected blood glucose probe 221 may be selected from among various sensors capable of measuring blood glucose. In this case, the continuous glucose measurement probe sensor 210 and the corrected glucose probe sensor 221 have a reversible reactive glucose antibody immobilized on the surface thereof, and detect a signal generated from the binding of glucose molecules in the body fluid of the reversible reactive glucose antibody It is preferable to include a cover sensor.

The continuous blood glucose measurement probe 210 and the corrected blood glucose probe 221 may include a carbon nanotube (CNT) hybrid sensor having boron doped diamond (BDD) Electrode. Diamond, which is a quaternary semiconductor element such as silicon, is an ultra-high-speed device material having a charge transfer speed of three times that of silicon and 4.5 times that of GaAs (gallium alsenide). The basic impedance of a sensor electrode made of gold or platinum The impedance of the carbon nanotube (CNT) hybrid sensor electrode structure in which the boron doped diamond (BDD) 111 is fixed on the surface is in the range of 1,000 to 3,200 Ω, . Therefore, they have extremely sensitive and efficient detection characteristics.

On the other hand, in the case of a carbon nanotube (CNT) hybrid sensor electrode on which boron doped diamond (BDD) is fixed on the surface, a conventional carbon nanotube (CNT: Carbon Nano Tube) (BDD) sensor, which has a much larger effective electrode area than the boron doped diamond (BDD) sensor.

As described above, the carbon nanotube (CNT) hybrid sensor electrode on which the boron-doped diamond (BDD) is fixed on the surface has a high sensitivity and a minimum detection limit, It is possible to perform sufficient measurement even if the depth of the user's skin is invaded only by a depth of about 2 to 5 mm at a depth of 10 mm or more. In addition, by reducing the depth of the penetration, the capillary length of the probe sensor can be reduced. As a result, fast reaction time and short settling time can be expected. In addition, despite the shortened sensing time, More accurate measurement becomes possible.

Meanwhile, since the continuous blood glucose measurement probe 210 and the corrected blood glucose probe 221 are each formed in the form of a probe, it is preferable to prevent the risk of contamination or piercing due to unnecessary exposure. As shown in FIGS. 1 and 3, the continuous blood glucose measurement probe through which the continuous blood glucose measurement probe 210 can pass can be detachably attached to the lower portion of the main body housing 110, And a corrected blood glucose measurement probe through hole 112 through which each of the corrected blood glucose probe sensors 221 can be inserted and through which the blood glucose measurement sensor cartridge 221 is inserted can be formed. And a replacement cover 110 formed on a central upper surface of the cartridge fixing support portion 113.

Next, the corrected blood glucose measurement driving unit 300 will be described. As shown in FIG. 2, the corrected blood glucose level measurement driving unit 300 performs a function of driving the plurality of corrected blood glucose probe sensors 221 according to the control of the main control unit 500 to sequentially invade and return to the user . As an embodiment for implementing the corrected blood sugar level measurement driving part 300 performing such functions, it is possible to select and implement one or more of a very wide variety of embodiments such as a mechanical type, a pneumatic type, a hydraulic type, and an electronic type. In this case, considering the condition that the hybrid continuous blood glucose measurement system 10 of the present invention is relatively small / light in weight which can be worn or attached, and the thickness thereof is desired to be thin, the corrected blood glucose measurement driving part 300 is compact, 2 and 3, it is preferable to include a corrected blood glucose measurement drive electromagnetic part 310 and a measurement arm drive part 320 so as to have an instantaneous bi-directional drive force suitable for the return operation.

1 and 2, the corrected blood glucose measurement drive arm 310 is disposed on the upper side of the corrected blood glucose measurement arm 220, respectively. 2 and 3, the measurement arm driving unit 320 is formed in the corrected blood glucose measurement arm 220 and includes a corrected blood glucose electromagnet coil pattern unit 321. [ In this case, when the invasive operation is performed, the corrected blood sugar level measurement driving unit 300 may include the corrected blood sugar level measurement driving electromagnet 310 and the measurement arm driving unit 320 are selectively driven to return after the invasive operation.

Meanwhile, the blood glucose measurement sensor cartridge 200 is preferably formed of a flexible printed circuit board (FPCB) having elasticity in the manufacturing process. In this case, it is preferable that the corrected blood glucose electromagnet coil pattern portion 321 is formed on the flexible printed circuit board (FPCB) in the form of a circuit pattern as shown in FIG.

In this case, the modified blood glucose electromagnet coil pattern portion 321 can be formed in various embodiments. 4 and 5, the corrected blood glucose electromagnet coil pattern portion 321 includes an upper surface pattern portion 322 formed in a plane coil shape on the upper surface of the measurement arm 320, And the upper surface pattern portion 322 formed on the lower surface of the measurement arm 320 in parallel with the upper surface pattern portion 322.

As another example of forming the corrected blood glucose electromagnet coil pattern portion 321 constituting the electromagnet coil, in order to further increase the driving force, as shown in FIGS. 4 and 6, A top surface pattern portion 322 formed on the top surface of the upper surface pattern portion 322 and formed in a shape of a plane coil on the upper surface of the measurement arm 320, And a lower surface pattern portion 323 'formed to have the same current rotation direction A' as the rotation direction A is further included.

In this case, when the blood glucose measurement sensor cartridge 200 is replaced, the continuous blood glucose measurement probe sensor 210, the corrected blood glucose probe sensor 221, and the corrected blood glucose electromagnet coil pattern unit 321 are connected to the blood glucose The blood glucose measurement sensor cartridge 200 and the main body housing 100 are provided with continuous blood glucose signal transmission electrodes 211a and 211b and a corrected blood glucose signal transmission electrode 211a and 211b respectively so as to be electrically connected to the measurement unit 400 and the main controller 500, It is preferable that the

transfer electrodes

222a and 222b and the corrected blood glucose

electromagnet driving electrodes

325a and 325b are provided.

Hereinafter, the operation of the corrected blood glucose level measurement driver 300 will be described with reference to FIG. As shown in (A) of FIG. 3, in the normal state, the continuous blood glucose measurement probe sensor 210 measures blood glucose continuously while being inserted into the skin S of the user, 221 are accommodated in the blood glucose measurement sensor cartridge mounting portion 101.

3 (B), the corrected blood glucose measurement electromagnet part 310 and the corrected blood glucose electromagnet coil pattern part 321 are arranged such that a magnetic pole is formed in a direction pushing each other, Is applied. Therefore, when the distal end of the corrected blood glucose measurement arm 220 is pushed downward by the repulsive force, the corrected blood glucose probe 221 is exposed through the corrected blood glucose measurement probe hole 112, And the corrected blood glucose is measured.

After the measurement of the corrected blood sugar is completed, as shown in Fig. 3 (B), the corrected blood glucose measurement drive electromagnetic portion 310 and the corrected blood glucose electromagnet coil pattern portion 321 are formed so that a magnetic pole is formed in a pulling direction with respect to each other Current is applied. Accordingly, the distal end of the corrected blood glucose measurement arm 220 is pulled upward by the pulling force, and the corrected blood glucose probe 221 is removed from the user's skin S, As shown in Fig.

On the other hand, after one calibration blood glucose measurement is completed, the calibration blood glucose measurement sensor 221 is operated to use another calibration blood glucose measurement probe 221 at an adjacent position instead of the already used calibration blood glucose probe 221 at the next calibration blood glucose measurement. Therefore, since the corrected blood glucose probe 221 is not invaded repeatedly at the same position, problems such as inflammation or infection that may occur when the same affected part is repeatedly infiltrated repeatedly can be fundamentally blocked.

Next, the blood sugar measuring unit 400 will be described. 2, the blood sugar measuring unit 400 corrects the blood glucose value measured by the continuous blood glucose level measurement probe sensor 210 according to the blood glucose value measured by the corrected blood glucose probe 221 And transmits the measurement result to the main control unit 500. Meanwhile, the blood sugar measuring unit 400 can separately process the blood glucose value measured by the corrected blood glucose probe 221 with the real time blood glucose value at the time of the measurement.

Next, the main control unit 500 will be described. As shown in FIG. 2, the main controller 500 is configured to control the driving of the corrected blood glucose level measurement driver 300 and to process and deliver blood glucose values measured by the blood glucose meter 400 . In this case, as shown in FIG. 2, it is preferable that the user interface 800 displays the blood glucose value received from the main control unit 500 and receives a user's operation input. As shown in FIG. 2, the user interface 800 includes a display 810 for visually displaying information such as various measured values and operating states, a display 810 for displaying information on a user's operation input (for example, And an operation input means 820 for inputting a corrected blood glucose measurement time interval setting and the like. In this case, the display 810 and the operation input unit 820 may be integrated through a touch-screen display panel.

In addition, it is preferable to measure oxygen saturation and heart rate together with blood glucose so as to be able to measure in advance a symptom of a cardiovascular-related disease which is likely to occur in a diabetic patient. As shown in FIGS. 1 and 2, an oxygen saturation degree sensor 620 installed on a lower surface of the main body housing 100 and a measurement value of the oxygen saturation degree measurement sensor 620 are used to detect the oxygen saturation degree And an oxygen saturation measuring unit 600 for transmitting the measured oxygen saturation to the main controller 500. In this case, the oxygen saturation measuring sensor 620 may be implemented through various embodiments. 1 and 2, the oxygen saturation measuring sensor 620 includes an oxygen saturation light emitting portion 621 and an oxygen saturation light receiving portion 622, And the like.

Here, the degree of oxygen saturation indicates the ratio of oxygen hemoglobin to the effective hemoglobin as a measure of the degree of binding of oxygen hemoglobin, and broadly refers to a ratio of the oxygen content in the sample blood and the percentage of the blood maximum oxygen content, The oxygen saturation of blood can be measured using the difference of the light absorption according to the oxygen saturation of hemoglobin.

The oxygen saturation light emitting unit 621 may include a red light source that emits red light having a large difference in light absorption between hemoglobin (Hb) and oxygen hemoglobin (HbO2), and a red light source that emits infrared light having a characteristic opposite to red light It is preferable that the light sources are configured as a pair.

It is also possible to measure the heart rate using the oxygen saturation measuring sensor 620. That is, when light is irradiated on the blood vessel, the brightness of the reflected light changes as the blood vessel is expanded or contracted by the blood flow that is moved by the pumping of the heart. At this time, it is also possible to measure the light whose brightness changes in real time due to the expansion and contraction of the mold, by measuring the oxygen saturation light-receiving portion 622 and measuring the heartbeat together. In this case, it is preferable to use a green light source having a complementary color relationship with the color of the blood as the oxygen saturation light emitting unit 621 so as to utilize the reflection characteristic according to expansion / contraction of the blood vessel as much as possible.

Through this oxygen saturation and heart rate measurement,

2, the sleep apnea state of the user is determined through the movement of the user measured by the three-dimensional acceleration sensor 710 installed in the main housing 100, and the main controller 500 And a sleep apnea measuring unit 700 for delivering the sleep apnea. That is, when sleep apnea usually occurs, the oxygen saturation is decreased according to the lack of oxygen in the blood, and the movement of the body including the chest cavity or abdominal motion due to breathing is reduced. Therefore, in addition to the measurement of the saturation saturation / heart rate, the user's movement measured by the three-dimensional acceleration sensor 710 can be measured to more effectively determine the user's sleep apnea state.

Next, the communication interface 900 will be described. The communication interface 900 is configured to transmit the measurement value including the blood glucose value received from the main control unit 500 to the user terminal 1 as shown in FIG. Meanwhile, the measured values transferred to the user terminal 1 may be managed and utilized through an application program driven by the user terminal 1. [

In the foregoing, optimal embodiments have been disclosed in the drawings and specification. Although specific terms have been employed herein, they are used for purposes of illustration only and are not intended to limit the scope of the invention as defined in the claims or the claims. Therefore, those skilled in the art will appreciate that various modifications and equivalent embodiments are possible without departing from the scope of the present invention. Accordingly, the true scope of the present invention should be determined by the technical idea of the appended claims.

Claims

1. A continuous blood glucose measurement system in which a user wears a blood glucose meter continuously to measure a blood glucose level of a user,

A body housing 110 worn by a user;

A blood glucose measurement sensor cartridge 200 that is replaceably mounted on the main body housing 100 and includes a continuous blood glucose measurement probe sensor 210 and a plurality of corrected blood glucose probe sensors 221;

A corrected blood glucose level measurement driver (300) driven by the plurality of corrected blood glucose probe sensors (221) under the control of the main controller (500) so as to sequentially invade and return to the user;

The blood glucose measurement unit 230 measures the blood glucose level measured by the continuous blood glucose level measurement probe 210 in accordance with the blood glucose level measured by the corrected blood glucose probe 221 and transmits the measured blood glucose level to the main control unit 500 400);

A user interface (800) for displaying the blood glucose value received from the main control part (500) and receiving an operation input of the user; (10). The hybrid continuous blood glucose measurement system (10) according to any one of claims 1 to 3,
The method according to claim 1,

The main body housing 110 includes a blood glucose measurement sensor cartridge mounting portion 101 on which the blood glucose measurement sensor cartridge 200 can be inserted and mounted; Further comprising:

The blood glucose measurement sensor cartridge (200)

The continuous blood glucose measurement probe 210 is provided at the center,

Each of the corrected blood glucose probe 221 is provided on the lower end of the outer side of the radially formed corrected blood glucose measuring arm 220,

The corrected blood glucose measurement driving unit 300,

A corrected blood sugar measuring and driving electromagnetic part (310) provided on the body housing (110) and positioned above the corrected blood sugar measuring arm (220), respectively;

A measurement arm driving unit 320 formed on the corrected blood sugar measuring arm 220 and configured to include a corrected blood glucose electromagnet coil pattern unit 321; And,

When the invasive operation is performed, the corrected blood glucose level measurement driving unit 300 measures only the corrected blood glucose level measurement driving electromagnet 310 and the measurement arm driving unit 320 corresponding to the corrected blood glucose probe 221 (10) is selectively driven to return after an invasive operation.
The method according to claim 2,

A cartridge guide 102 formed below the blood glucose measurement sensor cartridge mounting portion 101;

A guide hole 230 formed in the blood glucose measurement sensor cartridge 200 to allow the blood glucose measurement sensor cartridge 200 to be mounted at an accurate mounting position with the cartridge guide 102 inserted therein;

A continuous blood glucose measurement probe through hole 111 through which the continuous blood glucose measurement probe 210 can pass is centrally formed at the center of the body housing 110, And a sensor fixing hole 112 through which the blood glucose measurement sensor cartridge 200 can be inserted and through which the sensor 221 can be inserted, respectively, and a cartridge fixing support portion 113 capable of fixing the blood glucose measurement sensor cartridge 200 is formed on the central upper surface A replacement cover 110 formed; And further comprising:

The corrected blood glucose electromagnet coil pattern portion 321 includes:

An upper surface pattern portion 322 formed on the upper surface of the measurement arm 320;

The lower surface of the measurement arm 320 is connected to the upper surface pattern portion 322 and has a bottom surface 322 formed to have a current rotation direction A 'equal to the current rotation direction A of the top surface pattern portion 322, A pattern portion 323; (10). &Lt; RTI ID = 0.0 > 11. < / RTI >
The method according to claim 1,

An oxygen saturation measuring sensor 620 disposed on the lower surface of the main body housing 100 and an oxygen saturation measuring sensor 620 for detecting an oxygen saturation through the measured value of the oxygen saturation measuring sensor 620, (600); (10). &Lt; RTI ID = 0.0 > 11. < / RTI >
The method according to claim 4,

A sleep apnea measurement unit 700 for determining the sleep apnea state of the user through the movement of the user measured by the 3D acceleration sensor 710 installed in the main housing 100 and transmitting the determined sleep apnea state to the main controller 500 ); (10). &Lt; RTI ID = 0.0 > 11. < / RTI >
The method according to claim 1,

A communication interface (900) for transmitting the measurement value including the blood glucose value received from the main control part (500) to the user terminal (1); (10). &Lt; RTI ID = 0.0 > 11. < / RTI >