WO2017065565A1

WO2017065565A1 - Blood sugar measurement and sensing module having automatic calibration function and apparatus for continuous blood sugar measurement using same

Info

Publication number: WO2017065565A1
Application number: PCT/KR2016/011575
Authority: WO
Inventors: 이석원; 이재선; 차근식; 남학현
Original assignee: 주식회사 아이센스
Priority date: 2015-10-14
Filing date: 2016-10-14
Publication date: 2017-04-20
Also published as: KR101760899B1; KR20170044262A

Abstract

The present invention relates to a blood sugar measurement and sensing module having an automatic calibration function and an apparatus for continuous blood sugar measurement using the blood sugar measurement and sensing module. Only the needle for extracting bodily fluid is inserted into the body and the blood sugar concentration is measured in a measurement sensor located outside the body by transporting the bodily fluid by means of a transport pump, and as such, the unstable state of the sensor caused by inflammation, granuloma, blood clotting and the like which can arise in the body due to insertion of a sensor into the body can be prevented as the measurement sensor is not located inside the body, and consequently, the operational state of the sensor can be stably maintained to improve the accuracy of the blood sugar concentration measurement results.

Description

Blood glucose measurement sensing module with automatic calibration function and continuous glucose measurement device using the same

The present invention relates to a blood glucose measurement sensing module having an automatic calibration function and a continuous glucose measurement apparatus using the same. More specifically, only the bodily fluid extraction tube for extracting bodily fluid is inserted into the body, and the bodily fluid is transferred by a transfer pump to measure the blood glucose concentration by a measurement sensor located outside the body, so that the measuring sensor is not located in the body. Due to this, it is possible to prevent instability of the sensor due to inflammation, granulomas, blood clots, etc. occurring in the body. Accordingly, the sensor can be stably operated to improve the accuracy of blood glucose concentration measurement results. A separate blood glucose meter is used to verify the accuracy of the measurement sensor by supplying the calibration solution at each cycle and comparing the measurement value of the calibration solution with the reference blood glucose concentration value of the calibration solution. Automatically recalibrates without the need for blood collection at your fingertips, Accordingly, the pain and rejection of the blood collection process is eliminated, so that it is more convenient to use, and a blood glucose measurement sensing module having an automatic calibration function capable of calculating a more accurate measurement value by calculating a correction value using a calibration solution and using the same Continuous blood glucose measurement apparatus.

Recently, as the number of diabetics increases and the concern about the risk of diabetes increases, the demand for devices related to blood glucose measurement is steadily increasing. It has been confirmed through various studies that the occurrence of complications of diabetes is significantly reduced when diabetic patients strictly control blood glucose, and it is very important for diabetic patients to measure blood glucose regularly for glycemic control.

In general, a portable finger-prick method is commonly used to manage a blood glucose level of a diabetic patient. Although the blood glucose meter may help manage a blood glucose level of a diabetic patient, only the results at the time of measurement are shown. Because of this, there is a limit to knowing the blood sugar level that changes frequently.

In people with diabetes, they usually go between high and low blood sugar levels, and emergencies come from low blood sugar, and they may die if they are unconscious or have a low blood sugar for a long time without sugar. Therefore, the immediate detection of hypoglycemic state is very important for diabetics, but there is a limit to accurately grasp it with a blood glucose meter which measures blood glucose intermittently.

Recently, the Continuous Glucose Monitoring System (CGM), which is inserted into the human body and measures blood glucose levels at intervals of time, has been developed to overcome these limitations, thereby facilitating the management of diabetes patients and coping with emergencies. Can be done.

In addition, the blood glucose meter is a blood glucose measurement by diagnosing a blood glucose measurement by diagnosing the blood sugar of a patient with a needle to check his blood sugar, causing pain and rejection in the blood collection process. In order to minimize such pain and rejection, a research and development of a continuous blood glucose measurement system that continuously measures blood glucose after inserting a needle-like sensor into a region of the lower pain and abdomen has been conducted. The research and development of the Non-Invasive Glucose Monitoring System, which measures blood glucose without collecting blood, has also been actively conducted.

The non-invasive blood glucose measurement system has been studied for various methods such as optical method, electrical method, and exhalation measurement to measure blood glucose without collecting blood for the past 40 years. Cygnus, Redwoo City, Ca, USA, developed and released a wristwatch-type Glucowatch G2 Biographer using reverse ion osmosis, but had problems with skin irritation and blackness, problems with stopping sweating, high blood sugar In 2007, the company was discontinued due to problems with low blood sugar. To date, many bloodless blood glucose measurement techniques have emerged and are reported, but they are not used in practice due to their poor accuracy.

Continuous blood glucose measurement system is a needle-shaped sensor probe is inserted into the subcutaneous fat to measure the concentration of blood glucose in the interstitial fluid, it is configured in such a way to output the value of the measured blood glucose concentration through a separate terminal in real time. In this method, a 6-13 mm long needle-shaped sensor probe is inserted into the skin to measure blood glucose levels in the body. Therefore, there is a problem that the sensor becomes unstable due to inflammation, granulomas, or blood clots around the sensor probe inserted into the body. have. When the sensor becomes unstable in this way, the accuracy of the blood glucose concentration measured by the sensor is lowered. Therefore, in order to correct this problem, there is a problem in that blood is collected at the fingertips using a conventional blood glucose meter continuously, and then compared with the sensor measurement value of the continuous blood glucose measurement system, there is a problem of performing calibration and calibration.

That is, since the conventional continuous blood glucose measurement system according to the prior art is configured to measure blood glucose with the blood glucose measurement sensor inserted into the body in the form of a needle, the blood glucose measurement sensor becomes unstable due to inflammation, granulomas, thrombus, etc. in the body. Therefore, there is a problem that the accuracy of the blood glucose concentration measurement is lowered, and thus blood must be collected at the fingertips periodically using a conventional blood glucose meter for the test and calibration of the blood glucose measurement sensor. There is a problem that causes pain and rejection to the user.

The present invention is invented to solve the problems of the prior art, the object of the present invention is to leave the body fluid extraction tube for extracting the body fluid in the body and transfer the body fluid by a transfer pump to measure the blood glucose concentration in a measurement sensor located outside the body By doing so, since the measurement sensor is not located in the body, it is possible to prevent instability of the sensor due to inflammation, granulomas, blood clots, etc. occurring in the body due to insertion into the body, and thus the operating state of the sensor is stably maintained, thereby preventing blood sugar. Blood glucose measurement sensing module and continuous blood glucose measurement device that can improve blood glucose concentration at regular intervals by improving the accuracy of concentration measurement results and supplying body fluid to the measurement sensor by operating the transfer pump at regular intervals. To provide.

Another object of the present invention is to supply the calibration solution to the measurement sensor at regular intervals and to calculate and calibrate the measurement value of the measurement sensor by comparing the measurement value for the calibration solution with the reference blood glucose concentration value of the calibration solution, thereby improving the accuracy of the measurement sensor. For the purpose of verification, a separate blood glucose meter is used to automatically perform calibration without the need for blood sampling at the fingertips, and the pain and rejection of the blood collection process are eliminated for more convenient use. The blood glucose measurement sensing module and continuous blood glucose measurement using the same can calculate more accurate measurement value through the calibration calculation of the sensor and the sensor can be further cleaned by supplying the calibration solution to the measurement sensor. To provide a device.

The present invention, the body fluid extraction tube is inserted into the body is formed to extract the body fluid; A first transfer pump for extracting and transferring the body fluid from the body fluid extraction tube; A measurement sensor receiving the body fluid by the first transfer pump and measuring a blood glucose level of the supplied body fluid; And an attachment pad formed to be attached to the body, wherein the body fluid extraction tube, the first transfer pump, and the measurement sensor are mounted to the attachment pad, and the body fluid extraction tube is attached to the body. It is arranged to be inserted into the body, the body fluid extracted through the body fluid extraction tube is supplied to the measurement sensor located outside the body provides a blood glucose measurement sensing module for a continuous blood glucose measurement device, characterized in that the blood glucose concentration is measured.

At this time, the attachment pad has a calibration solution reservoir for storing the calibration solution therein, and a second transfer pump connected to each of the calibration solution reservoir and the measurement sensor through a connection tube so as to transfer the calibration solution to the measurement sensor. Can be mounted.

The blood glucose measurement sensing module may further include a pad controller mounted on the attachment pad and configured to receive a measurement value of the measurement sensor and to control operations of the first transfer pump and the second transfer pump. May be configured to transmit and receive information with an external device by a separate communication unit.

In addition, the attachment pad may be equipped with a discharge reservoir for storing the body fluid and the calibration solution supplied to the measurement sensor from the measurement sensor.

The pad controller may control the first transfer pump to operate every first period, and control the second transfer pump to operate every second period longer than the first period.

In addition, the pad control unit compares the blood glucose concentration measurement value for the calibration solution measured by the measurement sensor and the reference blood glucose concentration value of the calibration solution, and measuring the blood glucose concentration of the body fluid measured by the measurement sensor according to the comparison result The value can be calibrated.

In addition, the body fluid may include any one of cell interstitial fluid or blood.

In addition, the first transfer pump and the second transfer pump may be applied as an electroosmotic pump.

On the other hand, the present invention, the blood sugar measurement sensing module, an external terminal for transmitting and receiving information to and from the pad control unit of the blood sugar measurement sensing module, the external terminal is an operation unit which is formed so that the user can operate, and the measurement sensor An output unit for outputting a blood glucose concentration value of the body fluid measured by the present invention is provided.

In this case, the external terminal and the pad controller may transmit and receive information through a wireless communication method.

According to the present invention, only a needle for extracting body fluid is inserted into the body, and the body fluid is transferred by a transfer pump to measure blood glucose concentration by a measurement sensor located outside the body. It is possible to prevent sensor instability due to inflammation, granulomas, blood clots, etc. occurring in the body, and thus, the sensor can be stably operated to improve the accuracy of blood glucose measurement results. By supplying the body fluid to the measuring sensor by operating every time, there is an effect that the blood glucose concentration can be continuously measured at a predetermined cycle.

In addition, by supplying the calibration solution to the measurement sensor at regular intervals and comparing the measured value of the calibration solution with the reference blood glucose concentration value of the calibration solution to calculate and calibrate the measured value of the measurement sensor, With the Blood Glucometer, the calibration is performed automatically without the need for blood sampling at your fingertips, and the pain and rejection of the blood collection process is eliminated, making it easier to use. Through this, a more accurate measurement value can be calculated, and as the calibration solution is supplied to the measurement sensor, the measurement sensor is washed, thereby further improving the measurement accuracy of the measurement sensor.

1 is a view schematically showing the configuration of a continuous blood glucose measurement apparatus according to an embodiment of the present invention,

2 is a conceptual diagram conceptually showing a configuration of a blood glucose measurement sensing module for a continuous glucose measurement apparatus according to an embodiment of the present invention;

3 is a functional block diagram functionally showing a control related configuration of a blood glucose measurement sensing module for a continuous glucose measurement apparatus according to an embodiment of the present invention;

4 is an operation flowchart schematically illustrating an operation process of a blood glucose measurement sensing module for a continuous glucose measurement apparatus according to an embodiment of the present invention;

5 is a conceptual diagram conceptually illustrating a configuration of a blood glucose measurement sensing module for a continuous glucose measurement apparatus according to another embodiment of the present invention.

Hereinafter, exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings. First of all, in adding reference numerals to the components of each drawing, it should be noted that the same reference numerals are used as much as possible even if displayed on different drawings. In addition, in describing the present invention, when it is determined that the detailed description of the related well-known configuration or function may obscure the gist of the present invention, the detailed description thereof will be omitted.

1 is a view schematically showing the configuration of a continuous blood glucose measurement apparatus according to an embodiment of the present invention.

Continuous blood glucose measurement apparatus according to an embodiment of the present invention is a blood sugar measurement sensing module 10 attached to a portion of the body surface of the user to measure the blood sugar concentration, and an external terminal for transmitting and receiving information with the blood sugar measurement sensing module 10 ( 20).

Blood glucose measurement sensing module 10 is attached to a part of the body surface of the user to extract the body fluid from the outside, and configured to measure the blood sugar concentration through the separate measurement sensor, the measurement sensor is in the body The blood glucose concentration of the liquor is measured in vitro by being placed so as to be located outside the body instead of being inserted.

Therefore, since the measurement sensor 10 is not inserted into the body, the blood glucose measurement sensing module 10 according to an embodiment of the present invention can prevent instability of the measurement sensor due to inflammation, granulomas, blood clots, etc. occurring in the body, and The blood glucose level can be measured while maintaining a stable state at. In addition, the blood glucose measurement sensing module 10 may be supplied with a separate calibration solution to periodically perform the calibration and calibration work, by using a conventional blood glucose meter for the calibration and calibration work separately at the fingertips There is no need to collect blood, so you can use it more conveniently.

Detailed configuration of the blood glucose measurement sensing module 10 will be described in detail with reference to FIGS. 2 to 4.

The external terminal 20 is formed to transmit and receive information to and from the blood sugar measurement sensing module 10, by the operation unit 22 including an operation button and the like so that the user can operate, and the blood sugar measurement sensing module 10 An output unit 21 capable of outputting the measured blood glucose concentration value of the measured body fluid is provided.

In this case, the external terminal 20 and the blood glucose measurement sensing module 10 may be configured to transmit and receive information in a wireless communication method, but may be configured in a wired communication method.

On the other hand, the continuous blood glucose measurement apparatus according to an embodiment of the present invention may include a separate mobile communication terminal 30 for transmitting and receiving information with the external terminal 20 in a wireless communication method. The mobile communication terminal 30 may be applied to a smart phone, and may process and display the blood sugar measurement information received from the external terminal 20 through various applications in a variety of ways. In addition, the blood sugar measurement information transmitted from the external terminal 20 to the mobile communication terminal 30 may be transmitted and stored from the mobile communication terminal 30 to a separate management server (not shown), and the mobile communication terminal 30 may be It communicates with such a management server and can provide a variety of blood glucose measurement information to the user.

Hereinafter, a blood glucose measurement sensing module 10 according to an embodiment of the present invention will be described with reference to FIGS. 2 to 4.

2 is a conceptual diagram conceptually illustrating a configuration of a blood glucose measurement sensing module for a continuous glucose measurement apparatus according to an embodiment of the present invention, and FIG. 3 is a blood sugar measurement sensing module for a continuous glucose measurement apparatus according to an embodiment of the present invention. 4 is a functional block diagram functionally showing a control related configuration of FIG. 4 is an operation flowchart schematically illustrating an operation process of a blood glucose measurement sensing module for a continuous glucose measurement apparatus according to an embodiment of the present invention.

Blood glucose measurement sensing module 10 according to an embodiment of the present invention is a device for measuring the blood glucose concentration of the body fluid by extracting the liquid in the body, body fluid extraction tube 200 is inserted into the body to extract the body fluid And a first transfer pump 300 for extracting and transferring the medicinal solution through the bodily fluid extraction tube 200 and a measurement for measuring the blood glucose concentration of the bodily fluid by receiving the bodily fluid transferred and supplied by the first transfer pump 300. The sensor 400, the body fluid extraction tube 200, the first transfer pump 300, and the measurement sensor 400 are configured to include an attachment pad 100 attached to a user's body.

The bodily fluid extraction tube 200 is formed to extract bodily fluid from the body, and a microchannel is formed in the internal space so that the bodily fluid can be extracted. The other end of the body fluid extraction tube 200 is connected to the connection tube (T) for the transfer of the extracted body fluid. Here, the body fluid may be applied to any one of cell interstitial fluid or blood, and blood is used as a concept including any one of capillary blood, venous blood, and arterial blood. In addition, the bodily fluid extraction tube 200 may be formed in various forms to extract bodily fluids from the body, such as a bodily fluid extraction tube, cannula, or microdialysis tubing, and all of these forms collectively extract body fluids. It is called a coffin.

The first transfer pump 300 is connected through the body fluid extraction tube 200 and the connection tube (T) to extract and transfer the body fluid. The first transfer pump 300 is mounted on the attachment pad 100 attached to the user's body is very compact and can be applied to the electroosmotic pump according to an embodiment of the present invention. Electro-osmotic pump is a pump using the principle that fluid is moved by electro-osmosis phenomenon by placing electrodes on both ends of capillary tube or porous membrane and applying voltage to the electrode. It is noiseless and has the advantage of effectively controlling the flow rate in proportion to the applied voltage. Since the electroosmotic pump is widely used in the industrial field, a detailed description thereof will be omitted. Of course, in addition to the electroosmotic method, the first transfer pump 300 may be applied with various types of pumps such as a mechanical pump or an electromechanical pump.

The measurement sensor 400 is connected to the first transfer pump 300 through the connection tube T to receive and supply the body fluid, and to measure the blood glucose concentration of the supplied body fluid. That is, as shown in FIG. 2, the bodily fluid extraction tube 200 is partially inserted into the body, and the first transfer pump 300 is connected to the end of the bodily fluid extraction tube 200 through a connection tube T. The measurement sensor 400 is connected to the first transfer pump 300 through a connection tube T. When the first transfer pump 300 operates according to the structure, the body fluid is extracted through the body fluid extraction tube 200, and the extracted body fluid is supplied to the measurement sensor 400 through the first transfer pump 300. The measurement sensor 400 measures the blood glucose concentration with respect to the supplied body fluid, and the blood glucose concentration measurement method may be applied to various types of sensors such as a measurement sensor used for a general blood glucose meter, and to measure the blood glucose concentration. Since various measuring sensors of may be applied, a detailed description thereof will be omitted.

The attachment pad 100 is formed to be attached to a part of the body, for example, the skin of the belly or side. The attachment pad 100 may be attached to the body in various ways, such as by using a separate fixing band (not shown) or by attaching an adhesive to an edge portion and attaching it to the skin. The body fluid extraction tube 200, the first transfer pump 300, and the measurement sensor 400 are all mounted in the internal space of the attachment pad 100. In this case, the attachment pad 100 may be configured in such a manner that a separate housing part (not shown) is provided such that these components are accommodated in the internal space, and the shape thereof may be variously changed.

In this case, the bodily fluid extraction tube 200 may be arranged to be partially inserted into the body in a state where the attachment pad 100 is attached to the body. For example, the end of the bodily fluid extraction tube 200 may be disposed to protrude outward from the body attachment surface of the attachment pad 100. When the attachment pad 100 is attached to the body surface according to this structure, the attachment The bodily fluid extraction tube 200 mounted to the pad 100 is disposed in such a manner that its end is inserted into the body.

When the attachment pad 100 is attached to the body as described above, the body fluid extraction tube 200 is maintained in the inserted state in the body. When the first transfer pump 300 operates in this state, the body fluid extraction tube 200 is opened. The body fluid is extracted through the connection tube (T) and is transferred to the measurement sensor 400 located outside the body. As for the body fluid transferred to the measurement sensor 400, the blood glucose concentration is measured outside the body by the measurement sensor 400.

Therefore, the blood glucose measurement sensing module 10 according to an embodiment of the present invention maintains only the body fluid extraction tube 200 inserted into the body, and the measurement sensor 400 for measuring the blood glucose concentration is separately located outside the body. The body fluid is extracted and transferred from the body fluid extraction tube 200 to the measurement sensor 400 by the first transfer pump 300, and the blood glucose concentration of the body fluid is measured by the measurement sensor 400 located outside the body. According to this structure, since the measurement sensor 400 is not located in the body, the sensor may be prevented from being unstable due to inflammation, granulomas, blood clots, and the like, which occur in the body due to insertion into the body. The state remains stable, improving the accuracy of blood glucose measurement results. In addition, by operating the first transfer pump 300 at regular intervals, the body fluid can be extracted and supplied to the measurement sensor 400, and thus blood glucose concentration can be continuously measured at regular intervals.

Meanwhile, as illustrated in FIG. 2, the attachment pad 100 includes a calibration solution reservoir 510 for storing a calibration solution therein, a calibration solution reservoir 510 for transporting and supplying the calibration solution to the measurement sensor 400. A second transfer pump 500 may be further mounted to the measurement sensor 400, each connected via a connection tube T. In this case, a separate check valve 520 is provided in the connection tube T connecting the calibration solution reservoir 510 and the second transfer pump 500 to prevent the calibration solution from flowing back to the calibration solution reservoir 510. Can be mounted. Like the first transfer pump 300, the second transfer pump 500 may be an electroosmotic pump, and a mechanical pump or an electromechanical pump may be applied.

In addition, the pad control unit 600 may be further mounted on the attachment pad 100, and the pad control unit 600 receives the measurement value of the measurement sensor 400 as shown in FIGS. 2 and 3 and receives the first value. The operation of the transfer pump 300 and the second transfer pump 500 is controlled. In addition, the pad control unit 600 is formed to transmit and receive information with the external device by a separate communication unit 610. Here, the external device may be the external terminal 20 of the above-described continuous blood glucose measurement apparatus, and the external terminal 20 and the communication unit 610 of the pad controller 600 may transmit and receive information in a wireless communication method.

The calibration solution is a solution accurately prepared in a laboratory to have a reference blood glucose level of a specific value, and is used for various purposes. In one embodiment of the present invention, the calibration solution is used for the calibration operation and the calibration operation on the measurement sensor 400. do. That is, when the calibration solution is transferred to the measurement sensor 400 using the second transfer pump 500, the blood glucose concentration of the calibration solution is measured by the measurement sensor 400, and at this time, by the measurement sensor 400 By comparing the measured blood glucose concentration value with the reference blood glucose concentration value of the calibration solution itself, it is possible to verify the accuracy of the measured value of the measurement sensor 400.

For example, in the case of a calibration solution having a reference blood glucose concentration value of 10, when such a calibration solution is supplied to the measurement sensor 400, the measurement sensor 400 measures the blood glucose concentration for the supplied calibration solution, where the measurement If the value is 11, it is because the blood glucose concentration value measured by the measurement sensor 400 is wrong, based on the comparison result, the blood glucose concentration measurement value for the body fluid measured by the measurement sensor 400 reflects this Should be corrected. This correction operation is performed through the pad controller 600.

That is, the pad controller 600 receives the measured value measured by the measuring sensor 400, compares it with the reference blood glucose concentration value of the calibration solution, and compares the measured body fluid measured by the measuring sensor 400 according to the comparison result. Correcting and calculating the blood glucose concentration measurement value, and transmits the corrected calculated value to the external terminal 20 through the communication unit 610, the output unit 21 of the external terminal 20 to the blood glucose concentration Is output.

In this case, the pad controller 600 controls the operation of the first transfer pump 300 to operate every first period, and controls the operation of the second transfer pump 500 to operate every second period set longer than the first period. . For example, the first period may be set to 3 minutes and the second period may be set to 50 minutes. In this case, since the first transfer pump 300 operates every three minutes, the body fluid in the body is transferred to the measurement sensor 400 every three minutes from the body fluid extraction tube 200, and thus, the measurement sensor 400 Continue to measure blood glucose levels for body fluids every minute. At this time, since the second transfer pump 500 operates every 50 minutes, the calibration solution is transferred to the measurement sensor 400 every 50 minutes from the calibration solution reservoir 510, and thus, every 50 minutes in the measurement sensor 400. The blood glucose level for the calibration solution is measured. The blood glucose concentration measurement value for the calibration solution measured by the measurement sensor 400 is compared with the reference blood glucose concentration value of the calibration solution itself by the pad controller 600, and the body fluid measured by the measurement sensor 400 after this point in time. The blood glucose concentration measurement value is corrected and calculated according to the comparison result by the pad controller 600. According to such a correction operation, the blood glucose concentration value measured and calculated by the blood glucose measurement sensing module 10 according to an embodiment of the present invention always maintains high accuracy.

That is, the pad controller 600 determines whether or not the measured value of the measuring sensor 400 is correct at every second interval by comparing with the calibration solution, and corrects and calculates the measured value of the measuring sensor 400 according to the comparison result. Therefore, accurate blood glucose concentration values are always provided for calculation.

In addition, the calibration solution is supplied to the measurement sensor 400 at every second interval by the second transfer pump 500. When the calibration solution is supplied to the measurement sensor 400 in this way, the calibration sensor 400 is supplied by the calibration solution. ) Has the effect of washing. That is, as the body fluid is supplied to the measurement sensor 400 every first cycle, the measurement sensor 400 may be contaminated by various sediments contained in the body fluid. In this case, the calibration solution in a clean state is measured every second cycle. Since the sensor 400 is supplied to the sensor 400, the measurement sensor 400 is cleanly cleaned in the course of passing the calibration solution. Therefore, since the measurement sensor 400 is washed by the calibration solution every second period, contamination of the measurement sensor 400 is prevented, so that the accuracy of the measurement result of the measurement sensor 400 is further improved.

On the other hand, in general, the measurement sensor 400 measures the blood glucose concentration is a method of measuring the blood glucose concentration for the body fluid or calibration solution through an electrochemical signal in the course of the body fluid or calibration solution passing through the measurement sensor 400 Is done. Accordingly, the body fluid and the calibration solution supplied to the measurement sensor 400 are discharged from the measurement sensor 400 in the process of being measured by the measurement sensor 400, and, in addition, in the state in which the measurement is completed by the measurement sensor 400, It must be discharged from the measurement sensor 400 so that a bodily fluid or calibration solution can be supplied.

Therefore, according to an embodiment of the present invention, the attachment pad 100 may further include a discharge reservoir 700 so that the body fluid and the calibration solution supplied to the measurement sensor 400 may be discharged and stored from the measurement sensor 400. Can be.

In summary, the operation state described above according to the operation flow, the blood glucose measurement sensing module 10 according to an embodiment of the present invention as shown in Figure 4 when the first cycle reaches a first transfer (S10) The pump 300 is operated (S20), and the body fluid is supplied to the measurement sensor 400, and the blood glucose concentration for the body fluid is measured (S30). The blood glucose concentration measurement value measured by the measurement sensor 400 is calculated by the pad controller 600 (S40). Through such a repeating process, the blood glucose concentration of the body fluid may be continuously measured at each first cycle. In this process, when the second cycle is reached (S50), the second transfer pump 500 is operated (S60) so that the calibration solution is supplied to the measurement sensor 400 and the blood glucose concentration of the calibration solution is measured (S70). . Thereafter, the pad controller 600 compares the calibration solution blood glucose concentration measurement value with the reference blood glucose concentration value of the calibration solution (S80), and determines whether correction for the measured value of the measurement sensor 400 is necessary (S90). If correction is necessary, the correction value is reflected on the measured value of the measured sensor 400 afterwards (S100). That is, the measured value is calculated by reflecting the correction value with respect to the measured value of the measuring sensor 400 measured every first period thereafter.

1 to 4, the first transfer pump 300 and the second transfer pump 500 are mounted on the attachment pad 100, and the bodily fluid extraction tube 200 and the calibration solution reservoir 510 may include a first transfer pump ( 300 and the second transfer pump 500, respectively, but as illustrated in FIG. 5, only one transfer pump, that is, the first transfer pump 300 is mounted on the attachment pad 100, and the body fluid The extraction tube 200 and the calibration solution reservoir 510 may be configured to be connected to the first transfer pump 300 at the same time.

In more detail, the calibration solution reservoir 510 and the bodily fluid extraction tube 200 are connected to the first transfer pump 300 through separate connection tubes T, one end of which is connected to the first transfer pump 300. Two branch pipes (T2, T3) connected to the main pipe (T1) and the other end of the main pipe (T1) connected to the calibration solution reservoir (510) and the bodily fluid extraction pipe (200), respectively. It can be configured to include.

In this case, the valve 310 may be mounted to the connection tube T so that any one of the two branch pipes T2 and T3 may be selectively opened. As shown in FIG. 5, the valve 310 may be a flow path switching valve mounted at a branch point of the branch pipes T2 and T3. Alternatively, the valve 310 may be opened or closed mounted on each branch pipe T2 and T3. It can be applied in various forms such as a valve may be applied.

The pad controller 600 operates the valve 310 to extract and transfer the body fluid from the branch pipe T3 connected to the body fluid extraction pipe 200 during the time of extracting the body fluid and measuring the blood glucose concentration. The body fluid is extracted at every first cycle and transported to the measurement sensor 400 by the valve, and the valve 310 is transported from the branch pipe T2 connected to the calibration solution reservoir 510 at the second cycle interval. May be operated to cause the calibration solution to be transferred to the measurement sensor 400 every second period by the first transfer pump 300.

In this way, by allowing only one transfer pump to alternately transfer the body fluid and the calibration solution to the measurement sensor 400, the overall structure can be further simplified.

The above description is merely illustrative of the technical idea of the present invention, and those skilled in the art to which the present invention pertains may make various modifications and changes without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical idea of the present invention but to describe the present invention, and the scope of the technical idea of the present invention is not limited by these embodiments. The protection scope of the present invention should be interpreted by the following claims, and all technical ideas within the equivalent scope should be interpreted as being included in the scope of the present invention.

Claims

A body fluid extraction tube inserted into the body and formed to extract body fluids;

A first transfer pump for extracting and transferring the body fluid from the body fluid extraction tube;

A measurement sensor receiving the body fluid by the first transfer pump and measuring a blood glucose level of the supplied body fluid; And

Attachment pads formed to attach to the body

The body fluid extraction tube, the first transfer pump and the measuring sensor is mounted to the attachment pad, the body fluid extraction tube is arranged to be inserted into the body with the attachment pad attached to the body, the body fluid extraction tube The body fluid extracted through the blood glucose measurement sensing module for continuous blood glucose measurement device, characterized in that the transport is supplied to the measurement sensor located outside the body to measure the blood glucose concentration.
The method of claim 1,

The attachment pad

A calibration solution reservoir storing a calibration solution therein, and a second transfer pump connected to each of the calibration solution reservoir and the measurement sensor through a connection tube so that the calibration solution is transferred to the measurement sensor. Blood glucose measurement sensing module for a continuous blood glucose measurement device.
The method of claim 2,

A pad controller mounted on the attachment pad, the pad control unit receiving a measurement value of the measurement sensor and controlling the operation of the first transfer pump and the second transfer pump;

The pad control unit is a blood glucose measurement sensing module for a continuous blood glucose measurement device, characterized in that formed to transmit and receive information with an external device by a separate communication unit.
The method of claim 3, wherein

And a discharge reservoir for discharging and storing the body fluid and the calibration solution supplied to the measurement sensor from the measurement sensor.
The method of claim 3, wherein

The pad control unit

Operation control of the first transfer pump to operate every first period, and operation control of the second transfer pump to operate every second period set longer than the first period, blood glucose measurement for continuous blood glucose measurement apparatus Sensing module.
The method of claim 5,

The pad control unit

Comparing the blood glucose concentration measurement value for the calibration solution measured by the measurement sensor and the reference blood glucose concentration value of the calibration solution, and correcting and calculating the blood glucose concentration measurement value of the body fluid measured by the measurement sensor according to the comparison result A glucose measuring sensing module for a continuous glucose measuring apparatus.
The method according to any one of claims 1 to 6,

The body fluid is a blood glucose measurement sensing module for a continuous blood glucose measurement device, characterized in that it comprises any one of cell interstitial fluid or blood.
The method according to any one of claims 2 to 6,

The first and second transfer pumps, the blood glucose measurement sensing module for a continuous blood glucose measurement device, characterized in that applied as a mechanical pump, an electromechanical pump or an electroosmotic pump.
The method of claim 1,

The attachment pad

It is equipped with a calibration solution reservoir for storing the calibration solution inside,

And a calibration solution reservoir connected to the first transfer pump such that the calibration solution stored in the calibration solution reservoir is transferred to the measurement sensor.
The method of claim 9,

The calibration solution reservoir and the bodily fluid extraction tube are connected to the first transfer pump through separate connection tubes, and the connection tube is branched from the other end of the main tube and one end connected to the first transfer pump. Two branch pipes connected to the calibration solution reservoir and the body fluid extraction tube, respectively;

The connection tube is a glucose measuring sensing module for a continuous glucose measuring device, characterized in that the valve is mounted so that any one of the two branch pipes can be selectively opened.
A blood glucose measurement sensing module according to claim 5,

An external terminal for transmitting and receiving information with the pad control unit of the blood sugar measurement sensing module,

The external terminal

And an output unit for outputting a blood glucose concentration value of the body fluid measured by the measurement sensor, the control unit being configured to be operated by a user.
The method of claim 11,

The external terminal and the pad control unit is a continuous blood glucose measurement device, characterized in that for transmitting and receiving information in a wireless communication method.