WO2019017623A3 - 나노입자 어셈블리 구조체 및 이를 이용한 면역 분석 방법 - Google Patents

나노입자 어셈블리 구조체 및 이를 이용한 면역 분석 방법 Download PDF

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Publication number
WO2019017623A3
WO2019017623A3 PCT/KR2018/007555 KR2018007555W WO2019017623A3 WO 2019017623 A3 WO2019017623 A3 WO 2019017623A3 KR 2018007555 W KR2018007555 W KR 2018007555W WO 2019017623 A3 WO2019017623 A3 WO 2019017623A3
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Prior art keywords
assembly structure
nanoparticle assembly
nanoparticle
assembly
immunoassay method
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PCT/KR2018/007555
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English (en)
French (fr)
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WO2019017623A2 (ko
Inventor
현택환
김도균
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서울대학교산학협력단
기초과학연구원
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Publication of WO2019017623A2 publication Critical patent/WO2019017623A2/ko
Publication of WO2019017623A3 publication Critical patent/WO2019017623A3/ko

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
    • G01N33/553—Metal or metal coated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Inorganic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)

Abstract

나노입자 어셈블리 구조체 및 이를 이용한 면역 분석 방법이 제공된다. 상기 나노입자 어셈블리 구조체는, 복수 개의 제1 나노입자가 모여 이루어진 제1 어셈블리 입자를 포함하는 제1 나노입자 어셈블리 구조체를 포함하고, 상기 제1 어셈블리 입자는 자성을 갖는다. 본 발명의 실시예들에 따른 면역 분석 방법은, 완충 용액에 피분석물, 자성을 갖는 제1 나노입자 어셈블리 구조체, 및 발광성을 갖는 제2 나노입자 어셈블리 구조체를 제공하는 단계 및 상기 완충 용액에 자력을 제공하는 단계를 포함한다. 상기 제1 나노입자 어셈블리 구조체는, 복수 개의 제1 나노입자가 모여 이루어진 제1 어셈블리 입자, 및 상기 제1 어셈블리 입자에 연결된 제1 항체를 포함하고, 상기 제2 나노입자 어셈블리 구조체는, 복수 개의 제2 나노입자가 모여 이루어진 제2 어셈블리 입자, 및 상기 제2 어셈블리 입자에 연결된 제2 항체를 포함하며, 상기 제1 항체 및 상기 제2 항체는 상기 피분석물과 결합할 수 있다.
PCT/KR2018/007555 2017-07-20 2018-07-04 나노입자 어셈블리 구조체 및 이를 이용한 면역 분석 방법 WO2019017623A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020170092082A KR102001724B1 (ko) 2017-07-20 2017-07-20 나노입자 어셈블리 구조체 및 이를 이용한 면역 분석 방법
KR10-2017-0092082 2017-07-20

Publications (2)

Publication Number Publication Date
WO2019017623A2 WO2019017623A2 (ko) 2019-01-24
WO2019017623A3 true WO2019017623A3 (ko) 2019-04-11

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PCT/KR2018/007555 WO2019017623A2 (ko) 2017-07-20 2018-07-04 나노입자 어셈블리 구조체 및 이를 이용한 면역 분석 방법

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KR (1) KR102001724B1 (ko)
WO (1) WO2019017623A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102348003B1 (ko) * 2020-10-08 2022-01-07 연세대학교 산학협력단 이중 항체 연결 면역 샌드위치 분석을 이용한 타겟 바이오마커 검출방법

Citations (4)

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KR20110023673A (ko) * 2009-08-31 2011-03-08 서울대학교산학협력단 미세다공성 마그네타이트 및 이의 제조 방법
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Publication number Publication date
KR20190010001A (ko) 2019-01-30
WO2019017623A2 (ko) 2019-01-24
KR102001724B1 (ko) 2019-07-18

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