WO2019000772A1 - 一种适用于控制取卵过程中恒定流速抽吸卵泡液的操作台 - Google Patents

一种适用于控制取卵过程中恒定流速抽吸卵泡液的操作台 Download PDF

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WO2019000772A1
WO2019000772A1 PCT/CN2017/109028 CN2017109028W WO2019000772A1 WO 2019000772 A1 WO2019000772 A1 WO 2019000772A1 CN 2017109028 W CN2017109028 W CN 2017109028W WO 2019000772 A1 WO2019000772 A1 WO 2019000772A1
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flow rate
follicular fluid
flow
control device
switch
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PCT/CN2017/109028
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English (en)
French (fr)
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张宇晖
刘广芝
王璐
何巧花
张合龙
路锦
李杭生
谢娟珂
殷宝莉
常琼
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张宇晖
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Publication of WO2019000772A1 publication Critical patent/WO2019000772A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/43—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for artificial insemination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A61B17/425—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation
    • A61B17/435—Gynaecological or obstetrical instruments or methods for reproduction or fertilisation for embryo or ova transplantation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors

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  • the utility model relates to a biotechnology medical auxiliary device, in particular to a console suitable for controlling a constant flow rate to suck follicular fluid during an egg retrieval process.
  • In Vitro Fertilization refers to the technique of fertilization of mammalian sperm and eggs in a manually controlled environment in vitro, referred to as IVF in English. Because it is inseparable from embryo transfer technology (ET), it is also referred to as IVF-ET.
  • IVF-ET embryo transfer technology
  • Egg retrieval is one of the important surgical operations during in vitro fertilization-embryo transfer.
  • the smoothness of the egg retrieval process also affects the outcome of in vitro fertilization-embryo transfer.
  • Conventional egg retrieval is a process in which the flow rate is adjusted by the operator to adjust the pressure to aspirate the follicular fluid during the puncture and egg retrieval process. In this process, the flow rate cannot be controlled.
  • both the fast and slow flow rate will cause mechanical damage of the egg, thus affecting fertilization and cleavage, so monitoring and formulating a suitable flow rate can better preserve the vitality of the egg.
  • the purpose of the present invention is to provide a console suitable for controlling the flow rate of follicular fluid at a constant flow rate during the egg retrieval process in order to solve the defect that the existing follicular fluid is pumped by the estimated flow rate.
  • a console suitable for controlling a constant flow rate to suck follicular fluid during the egg retrieval process comprising a flow detecting sensor, a flow control device, a data display screen and a switch, the flow detecting sensor and the data display
  • the screen and the switch are respectively connected to the flow control device
  • the flow detecting sensor is connected to the follicular liquid conduit for detecting the flow velocity of the follicular fluid in the follicular fluid conduit
  • the flow control device is connected with the vacuum suction device.
  • the flow rate of the negative pressure suction device is controlled by the flow control device according to the set flow rate, and the flow control device is adapted to control the flow rate of the negative pressure suction pump according to the set flow rate. Maintain a constant flow rate during the egg process without causing mechanical damage to the egg.
  • the flow detecting sensor is non-contact mounted on the follicular fluid conduit.
  • the switch is a foot switch.
  • FIG. 1 is a schematic view showing the structure of a console for controlling a constant flow rate of follicular fluid during the egg retrieval process according to the present invention.
  • FIG. 1 is a structural diagram of a console for controlling a constant flow rate of aspirating follicular fluid during an egg retrieval process, which includes a flow detecting sensor 1, a flow control device 2, a data display screen 3, and Switch 4. Flow detection sensor 1, data display 3, switch 4 They are connected to the flow control device 2, respectively.
  • the flow detecting sensor 1 is connected to a follicular fluid conduit for detecting the flow rate of the follicular fluid in the follicular fluid conduit. Specifically, the flow detecting sensor 1 is non-contactly mounted on the follicular fluid conduit.
  • the flow control device 2 has pressurization and decompression output information such that the flow rate of the follicular fluid in the follicular fluid conduit reaches a set value.
  • the flow control device 2 is connected to an external vacuum suction device for controlling the pressure of the vacuum suction device.
  • the flow control device 2 has a PID tuning algorithm that can quickly and stably control the vacuum suction device to maintain a constant flow rate.
  • the data display screen 3 is used to display the current flow rate of the follicular fluid, set flow rate, total capacity, total time and the like in real time.
  • the switch 4 is used to control the opening and closing of the flow control device 2.
  • the switch 4 is a foot switch, and the start and stop of the flow control device 2 is controlled by the foot switch 4, so that the egg washing operation can be completed by a single person.
  • the principle of the console is as follows: the flow rate detecting sensor 1 is used to detect the flow rate of the follicular fluid in real time, and after the flow rate control device 2 obtains the flow rate, it is compared with the set flow rate, and the pressure of the vacuum suction device is controlled by the PID control algorithm to change the flow rate. Finally, a constant flow rate equal to the set value is reached.
  • the specific operation is as follows: Before taking the egg, the egg-taking needle and the egg-removing tube are installed, the flow detecting sensor 1 is mounted on the egg-removing liquid conduit, the flow rate is set, and the foot switch 4 is depressed, in the process of puncture the follicle
  • the medium flow control device 2 controls the vacuum suction device to maintain a constant flow rate in accordance with the flow rate while the relevant data is displayed on the data display screen 3.
  • the station adapted to control the constant flow rate of the follicular fluid during the egg retrieval process utilizes the flow rate obtained by the flow detecting sensor 1, and the flow control device controls the pressure of the vacuum suction device according to the set flow rate to ensure that the egg suction is maintained during the egg retrieval process.
  • the constant flow rate does not cause mechanical damage to the egg; the injection device is controlled by the foot switch, and the single person can complete the egg retrieval process.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
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Abstract

一种适用于控制取卵过程中恒定流速抽吸卵泡液的操作台，包括流量检测传感器(1)、流量控制装置(2)、数据显示屏(3)和开关(4)。流量检测传感器(1)、数据显示屏(3)、开关(4)分别与流量控制装置(2)连接，流量检测传感器(1)用于检测该卵泡液导管内的卵泡液的流速，流量控制装置(2)用于控制卵泡液导管内的卵泡液的流速达到设定值。该操作台利用流量检测传感器(1)获取的流速，流量控制装置(2)根据设定流速控制负压吸引器压力大小，保证在取卵过程中保持恒定的流速，不会对卵子造成机械损伤。

Description

一种适用于控制取卵过程中恒定流速抽吸卵泡液的操作台 技术领域
本实用新型涉及一种生物科技医疗辅助设备，具体涉及一种适用于控制取卵过程中恒定流速抽吸卵泡液的操作台。
背景技术
在体外受精(In Vitro Fertilization)是指哺乳动物的精子和卵子在体外人工控制的环境中完成受精过程的技术，英文简称为IVF。由于它与胚胎移植技术(ET)密不可分，又简称为IVF-ET。在生物学中，把体外受精胚胎移植到母体后获得的动物称试管动物(test-tube animal)。这项技术成功于20世纪50年代，在最近20年发展迅速，现已日趋成熟而成为一项重要而常规的动物繁殖生物技术引。
取卵作为体外受精-胚胎移植过程中重要的手术操作之一，取卵过程的顺利性也影响体外受精-胚胎移植的结局。常规取卵是在穿刺取卵过程中通过操作人员目测流速以调整压力大小抽吸卵泡液获得卵子的过程，在这过程中，流速无法控制。当存在个体差异时，即在相同的压力下，流速的快和慢均会造成卵子的机械性损伤，从而影响受精及卵裂，故监测及制定合适的流速能更好的保存卵子的活力。
实用新型内容
本实用新型的目的是针对上述现状，提供一种适用于控制取卵过程中恒定流速抽吸卵泡液的操作台，以解决现有通过预估流速设定压力抽吸卵泡液的缺陷。
本实用新型采用的技术方案：一种适用于控制取卵过程中恒定流速抽吸卵泡液的操作台，包括流量检测传感器、流量控制装置、数据显示屏和开关，所述流量检测传感器、数据显示屏、开关分别与所述流量控制装置连接，所述流量检测传感器与卵泡液导管连接，用于检测该卵泡液导管内的卵泡液的流速，所述流量控制装置与负压吸引器连接，用于控制所述负压吸引器的压力大小，从而控制所述卵泡液导管内的卵泡液的流速达到设定值，所述数据显示屏用于实时显示当前卵泡液的流速、设定流速、总容量和总时间，所述开关用于控制所述流量控制装置的开启和关闭。
本技术方案的效果是：该适用于控制取卵过程中恒定流速抽吸卵泡液的操作台利用流量检测传感器获取的流速，流量控制装置根据设定流速控制负压吸引器压力大小，保证在取卵过程中保持恒定的流速，不会对卵子造成机械损伤。
进一步地，所述流量检测传感器非接触式安装在所述卵泡液导管上。
进一步地，述开关为脚踏开关。
附图说明
图1所示为本实用新型提供的一种适用于控制取卵过程中恒定流速抽吸卵泡液的操作台的结构示意图。
具体实施方式
以下结合附图对本实用新型的原理和特征进行描述，所举实例只用于解释本实用新型，并非用于限定本实用新型的范围。
请参阅图1，为本实用新型提供的一种适用于控制取卵过程中恒定流速抽吸卵泡液的操作台的结构示意图，其包括流量检测传感器1、流量控制装置2、数据显示屏3和开关4。流量检测传感器1、数据显示屏3、开关4 分别与流量控制装置2连接。
流量检测传感器1与卵泡液导管连接，用于检测该卵泡液导管内的卵泡液的流速。具体地，流量检测传感器1非接触式安装在该卵泡液导管上。
流量控制装置2具有加压和减压输出信息，从而使卵泡液导管内的卵泡液的流速达到设定的值。流量控制装置2与外部的负压吸引器连接，用于控制该负压吸引器的压力大小。流量控制装置2具有PID整定算法，能快速稳定地控制该负压吸引器，保持恒定流速。
数据显示屏3用于实时显示当前卵泡液的流速、设定流速、总容量、总时间等相关信息。
开关4用于控制流量控制装置2的开启和关闭。具体地，开关4为脚踏开关，通过脚踏开关4来控制流量控制装置2的启停，如此可以单人完成取卵冲洗操作。
本操作台的原理如下：利用流量检测传感器1实时检测卵泡液的流速，流量控制装置2获得该流速后，与设定的流速进行比较，通过PID控制算法控制该负压吸引器压力大小改变流速，最终达到与设定值一样大小的恒定流速。
具体操作如下：在取卵前，将取卵针、取卵管安装完毕，将流量检测传感器1装在该取卵液导管上，设定好流速，踩下脚踏开关4，在穿刺卵泡过程中流量控制装置2根据流速控制该负压吸引器保持恒定流速，同时相关的数据显示在数据显示屏3上。
如此，该适用于控制取卵过程中恒定流速抽吸卵泡液的操作台利用流量检测传感器1获取的流速，流量控制装置根据设定流速控制负压吸引器压力大小，保证在取卵过程中保持恒定的流速，不会对卵子造成机械损伤；通过脚踏开关控制注射装置，单人可以完成取卵过程。
以上所述仅为本实用新型的较佳实施例，并不用以限制本实用新型，凡在本实用新型的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本实用新型的保护范围之内。

Claims (3)

  1. 一种适用于控制取卵过程中恒定流速抽吸卵泡液的操作台，其特征在于，包括流量检测传感器、流量控制装置、数据显示屏和开关，所述流量检测传感器、数据显示屏、开关分别与所述流量控制装置连接，所述流量检测传感器与卵泡液导管连接，用于检测该卵泡液导管内的卵泡液的流速，所述流量控制装置与负压吸引器连接，用于控制所述负压吸引器的压力大小，从而控制所述卵泡液导管内的卵泡液的流速达到设定值，所述数据显示屏用于实时显示当前卵泡液的流速、设定流速、总容量和总时间，所述开关用于控制所述流量控制装置的开启和关闭。
  2. 如权利要求1适用于控制取卵过程中恒定流速抽吸卵泡液的操作台，其特征在于：所述流量检测传感器非接触式安装在所述卵泡液导管上。
  3. 如权利要求1适用于控制取卵过程中恒定流速抽吸卵泡液的操作台，其特征在于：述开关为脚踏开关。
PCT/CN2017/109028 2017-06-26 2017-11-02 一种适用于控制取卵过程中恒定流速抽吸卵泡液的操作台 WO2019000772A1 (zh)

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WO2014100294A1 (en) * 2012-12-18 2014-06-26 Drummond Scientific Company Method and apparatus for controlling in vitro fertilization
CN104075977A (zh) * 2014-07-18 2014-10-01 苏州大学 一种细胞吸吐测量装置
WO2014191757A1 (en) * 2013-05-31 2014-12-04 Labman Automation Ltd Ivf egg collection chamber
CN104498321A (zh) * 2014-11-06 2015-04-08 徐小杨 卵细胞自动识别分选装置
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CN101791239A (zh) * 2010-02-10 2010-08-04 江西诺德医疗器械有限公司 一次性使用单腔取卵针
WO2014100294A1 (en) * 2012-12-18 2014-06-26 Drummond Scientific Company Method and apparatus for controlling in vitro fertilization
WO2014191757A1 (en) * 2013-05-31 2014-12-04 Labman Automation Ltd Ivf egg collection chamber
CN104075977A (zh) * 2014-07-18 2014-10-01 苏州大学 一种细胞吸吐测量装置
CN104498321A (zh) * 2014-11-06 2015-04-08 徐小杨 卵细胞自动识别分选装置
CN204765843U (zh) * 2015-06-30 2015-11-18 北京大学深圳医院 体外受精取卵装置

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