WO2018233317A1

WO2018233317A1 - Self-cleaning degradable chitosan toothbrush and preparation method therefor

Info

Publication number: WO2018233317A1
Application number: PCT/CN2018/077975
Authority: WO
Inventors: 于永臣
Original assignee: 青岛容商天下网络有限公司
Priority date: 2017-06-21
Filing date: 2018-03-05
Publication date: 2018-12-27
Also published as: CN107307579A

Abstract

A self-cleaning degradable chitosan toothbrush and a preparation method therefor. The toothbrush comprises bristles. The raw material components of the bristles comprise chitosan, a polylactic acid solution, and a rosin solution. The toothbrush further comprises a handle and a head; the head is provided at one end of the handle; the handle is arc-shaped; the bending direction of the front half of the handle is the same as that of the head, and the bending direction of the rear half of the handle is opposite to that of the head; the head and the handle are both made of degradable materials. The toothbrush is convenient to use and environmentally friendly, and needs no toothpaste during use; the toothbrush is actively worn in a tooth brushing process, and micro-particles produced in the wear process can achieve efficient bactericidal and frictional effects. In addition, the toothbrush itself has antibacterial and bacteriostatic effects, so that the reproduction of harmful microorganisms such as bacteria is avoided even if the used bristles are exposed to the air for a long time. Therefore, the toothbrush better protects oral hygiene and has a high application value.

Description

Self-cleaning degradable chitosan toothbrush and preparation method thereof

Technical field

The invention relates to the technical field of oral hygiene devices, in particular to a self-cleaning degradable chitosan toothbrush and a preparation method thereof.

Background technique

Brushing your teeth is a must-have activity in people's daily lives. When you travel, travel or camp, you often encounter a toothbrush without a toothpaste. Therefore, a toothbrush that does not require toothpaste becomes a necessity. In addition, the traditional toothbrush used in daily life has serious safety hazards: the bristles have a large specific surface area, which causes the bristles that are wet after use and hides food residue and tooth dirt to breed bacteria and other microorganisms when directly exposed to the air, seriously damaging the human body. Health; in other words, traditional toothbrushes cannot kill the harmful microbes that breed on the bristles.

In the traditional toothbrush, CN201510060032.5 discloses an ultrasonic toothbrush: the ultrasonic vibration frequency is used to break the food residue and plaque, and the bristles are easily cleaned, thereby achieving the purpose of cleaning the oral cavity, but the toothbrush is expensive and long-term use may cause the human body hurt. CN200710003433.2 discloses a toothbrush which stores a cleaning sterilizing agent with a hollow toothbrush handle: the bristles are hollow and communicate with the cavity of the handle, and the cleaning agent flows to the tooth surface through the hollow lumen of the bristles when brushing; the disadvantage of the toothbrush is that it is usually When the brush is not brushed, the detergent will flow out of the bristles, or the amount of detergent flowing out during brushing is uncontrollable; in addition, the detergent is equivalent to toothpaste, which does not essentially change the limitations of using toothpaste. For disposable brushing appliances on the market: a disposable toothbrush and a small tube of toothpaste are packaged together, but the toothpaste is often not opened, and the toothpaste tube residue and the disposable toothbrush discarded after use are not degradable, polluting the environment, Wasted resources.

Based on this, it is especially important to develop a new type of toothbrush that can effectively sterilize and prevent various oral problems.

Summary of the invention

In view of the deficiencies in the prior art, the present invention aims to provide a self-cleaning degradable chitosan toothbrush and a preparation method thereof. The toothbrush provided by the invention is convenient to use, environment-friendly and does not need toothpaste during use; the toothbrush of the invention actively wears during the brushing process, and the micro-particles generated during the abrasion process can effectively sterilize and rub; The bristles of the invention have antibacterial and antibacterial effects, and the used bristles are exposed to the air for a long time without reproducing harmful microorganisms such as bacteria, thereby better protecting oral hygiene and having wide application value.

To this end, the present invention provides the following technical solutions:

In a first aspect, the present invention provides a toothbrush comprising a bristles; a raw material component of the bristles comprising a first mixture; and a first mixture comprising a chitosan, a polylactic acid solution and a rosin solution.

In a further embodiment of the present invention, the mass ratio of the mass of the chitosan to the solute polylactic acid in the polylactic acid solution is (1 to 2.5): 10, and the mass concentration of the polylactic acid solution is 4% to 10%, and The polylactic acid solution is a solution of polylactic acid in acetic acid; the mass of chitosan is not more than 2% of the mass of the polylactic acid solution; the mass ratio of the solute rosin in the rosin solution to the solute polylactic acid in the polylactic acid solution is 1: (6-15); The rosin solution is a rosin ethanol solution, and the mass percentage of the rosin ethanol solution is 9% to 11%.

In a further embodiment of the invention, the raw material component of the bristles further comprises a second mixture; the second mixture comprises dandelion, notoginsenoyl and sodium lauroyl sarcosinate; wherein, dandelion, notoginseng and sodium lauroyl sarcosinate The mass ratio is (1 to 1.5) in order: (0.3 to 0.5): 1. The preparation method of the second mixture comprises the following steps: S301: soaking dandelion and notoginseng with water for 36h to 48h, turning every 3h, then filtering and collecting the filtrate; wherein, for each kilogram of dandelion, the added mass of water is 18L-22L; S302: adding sodium lauroyl sarcosinate to the filtrate and stirring uniformly to obtain a second mixture.

In a further embodiment of the present invention, the toothbrush further includes a handle and a brush head; wherein the brush head is disposed at one end of the handle, and the brush head has an arc of 0.5 to 1.0 rad, a length of 2 to 3 cm, and a width of 1.5 to 2cm plate-like structure, and the side of the brush head near the arc center is the front side, and the side away from the arc center is the back side; the bristles are disposed on the front side of the brush head, and the length of the bristles is 0.5-0.8 cm; The arc shape is the same, and the bending direction of the front half of the handle is the same as the bending direction of the brush head. The bending direction of the rear half of the handle is opposite to the bending direction of the brush head. The curvature of the handle is 0.8-1.2 rad and the length is 12-18 cm. The end and back of the brush head are covered with silicone.

In a further embodiment of the invention, both the brush head and the handle are made of a degradable material.

In a second aspect, the present invention provides a method for preparing a toothbrush, comprising the steps of: S101: dissolving chitosan in a polylactic acid solution to obtain a first intermediate solution; and S102: adding a rosin solution to the first intermediate solution and stirring Uniformly, obtaining a second intermediate solution, specifically stirred in a sealed container for 15 min to 60 min; S103: adding a sodium hydroxide solution to the second intermediate solution to obtain a third intermediate solution; S104: adding to the third intermediate solution The porogen is then exposed to air for 1 h to obtain a glue solution; S105: the glue is made into a silk and then shaped to obtain bristles.

In a further embodiment of the present invention, in S102, the ratio of the volume of the rosin solution to the volume of the first intermediate solution is 1: (10-20); and the preparation method of the rosin solution comprises: dissolving the rosin after being dissolved in the anhydrous Stir in ethanol and obtain a rosin solution. It will be appreciated by those skilled in the art that since the rosin is susceptible to oxidation, the rosin should not be allowed to stand in air for more than 1 hour after grinding, preferably immediately dissolved in ethanol.

In a further embodiment of the present invention, in S103, the molar ratio of the solute sodium hydroxide in the sodium hydroxide solution to the acetic acid in the second intermediate solution is 1:1; the mass percentage concentration of the sodium hydroxide solution is 15%-25 %, and the drop rate per minute is less than 60 drops; in S104, the porogen is sodium chloride and/or potassium chloride; and the porogen is added in an amount of 2 to 3 g per 100 mL of the third intermediate solution.

In a further embodiment of the present invention, in S105, after the glue is made into a wire, the shaping comprises: S201: forming a glue into a filament by a wire drawing machine, and then drying and shaping the filament to obtain a first original yarn; S202: rinsing the first strand with distilled water to remove the porogen, and then drying to obtain a second strand; S203: soaking the second strand in the second mixture, ultrasonically stirring for 10 min to 20 min, and then hanging indoors until The water is not dripped downward, and then dried at a low temperature of 60 ° C to 65 ° C to remove moisture to obtain a bristled raw material yarn; wherein the mass ratio of the second mixture to the second raw yarn is (800 to 1200): 1; S204 : The bristles are made into a tuft of toothbrushes to obtain bristles.

In a further embodiment of the present invention, in S101 to S105, the operating temperature is 20 ° C to 28 ° C; in S201 to S204, the drying temperature is 60 ° C to 65 ° C.

The above technical solution provided by the present invention has the following advantages:

(1) Applicants have found through a large number of experiments that the toothbrush provided by the present invention is convenient to use, environmentally friendly, and does not require toothpaste during use; the self-cleaning degradable chitosan toothbrush of the present invention actively wears during brushing, and is worn during wear. The generated micro-particles can play an effective bactericidal and rubbing effect; in addition, the bristles of the present invention have antibacterial and antibacterial effects, and the used bristles are exposed to the air for a long time without reproducing harmful microorganisms such as bacteria, thereby better protecting Oral hygiene has a wide range of applications.

(2) The raw material component of the bristles of the invention belongs to natural materials, has no toxic and side effects, and is more friendly to the human body; the rosin can effectively fill the chain break between chitosan and polylactic acid, and significantly enhance the plasticity and elasticity of the bristles. So that it is not easy to break; dandelion can help kill bacteria on the surface of teeth and other parts of the mouth, prevent plaque, dandelion also has anti-tumor effect, effectively prevent the production of oral cancer; Sanqi has the effect of blood, hemostasis, It can effectively prevent or relieve the symptoms of bleeding gums; sodium lauroyl sarcosinate in raw materials can produce foam when brushing teeth, thus replacing traditional toothpaste.

(3) The curved brush head of the invention is more in conformity with the human oral structure, so as to be more conformable to the tooth surface; the silica gel covered on the brush head serves as a cushioning function, and reduces the injury and pain caused when the brushing tooth scrapes the gums and the ankle. The length of the bristles of the present invention is 0.5 to 0.8 cm, which avoids the feeling of discomfort when brushing the gums based on the narrow space between the human gums and the inner wall of the oral cavity.

(4) The raw material components of the invention are simple and easy to obtain, and the cost is low, and the preparation method has the advantages of stable process, high yield, good quality, low energy consumption, wide raw materials and simple process, and the production can be completed by using existing equipment. The equipment requirements are reduced, and the brush head bristles can be degraded, naturally decomposed after being discarded, and have zero pollution to the environment, thereby having wide application value.

The additional aspects and advantages of the invention will be set forth in part in the description which follows.

DRAWINGS

Figure 1 is a front elevational view of the self-cleaning degradable chitosan toothbrush of the present invention;

Figure 2 is a side elevational view of the self-cleaning degradable chitosan toothbrush of the present invention.

Detailed ways

The embodiments of the technical solution of the present invention will be described in detail below. The following examples are only intended to illustrate the technical solutions of the present invention more clearly, and thus are not intended to limit the scope of the present invention.

The experimental methods in the following examples are conventional methods unless otherwise specified.

The test materials used in the following examples, unless otherwise specified, were purchased from conventional reagent stores.

For the quantitative tests in the following examples, three replicate experiments were set up, and the data were the mean or mean ± standard deviation of three replicate experiments.

1 is a front view of a self-cleaning degradable chitosan toothbrush of the present invention; FIG. 2 is a side view of the self-cleaning degradable chitosan toothbrush of the present invention, as shown in FIGS. 1 and 2: the present invention provides a toothbrush. The toothbrush comprises bristles; the raw material component of the bristles comprises a first mixture; the first mixture comprises chitosan, a polylactic acid solution and a rosin solution. In addition, the toothbrush further comprises a handle and a brush head; the brush head is disposed at one end of the handle, and the brush head is a plate-like structure having an arc of 0.5 to 1.0 rad, a length of 2 to 3 cm, and a width of 1.5 to 2 cm, and the brush head The side near the center of the arc is the front side, the side away from the center of the arc is the back side; the bristles are disposed on the front side of the brush head, and the length of the bristles is 0.5-0.8 cm; the handle is curved, and the front half of the handle is The bending direction is the same as the bending direction of the brush head, and the bending direction of the rear half of the handle is opposite to the bending direction of the brush head. The curvature of the handle is 0.8 to 1.2 rad and the length is 12 to 18 cm. And the brush head and the handle are made of a degradable material.

Preferably, the mass ratio of the mass of the chitosan to the solute polylactic acid in the polylactic acid solution is (1 to 2.5): 10, the mass concentration of the polylactic acid solution is 4% to 10%, and the polylactic acid solution is polylactic acid. The acetic acid solution; the mass ratio of the solute rosin in the rosin solution to the solute polylactic acid in the polylactic acid solution is 1: (6-15); and the rosin solution is a rosin ethanol solution, and the mass percentage concentration of the rosin ethanol solution is 9%~ 11%.

Preferably, the raw material component of the bristles further comprises a second mixture; the second mixture comprises dandelion, notoginsenoyl and sodium lauroyl sarcosinate; wherein the mass ratio of dandelion, notoginsenoyl and sodium lauroyl sarcosinate is (1) ～1.5): (0.3～0.5): 1; wherein the preparation method of the second mixture comprises the following steps: S301: soaking dandelion and notoginseng with water for 36h to 48h, then filtering and collecting the filtrate; wherein, per kilogram of dandelion, The water is added in a mass of 18 L to 22 L; S302: sodium lauroyl sarcosinate is added to the filtrate obtained in S301, and stirred uniformly to obtain a second mixture.

In addition, with respect to the toothbrush of the present invention, the present invention specifically designs a preparation method comprising the following steps:

S101: Dissolving chitosan in a polylactic acid solution to obtain a first intermediate solution.

S102: adding a rosin solution to the first intermediate solution and stirring uniformly to obtain a second intermediate solution. Wherein, the preparation method of the rosin solution comprises: pulverizing the rosin, dissolving in absolute ethanol and stirring uniformly to obtain a rosin solution.

S103: adding a sodium hydroxide solution to the second intermediate solution to obtain a third intermediate solution. Wherein, the molar ratio of the solute sodium hydroxide in the sodium hydroxide solution to the acetic acid in the second intermediate solution is 1:1; the mass percentage concentration of the sodium hydroxide solution is 15% to 25%, and the droplet acceleration per minute is less than 60 drop.

S104: adding a porogen to the third intermediate solution, and then standing to obtain a glue. Wherein, the porogen is sodium chloride and/or potassium chloride; and the porogen is added in an amount of 2 to 3 g per 100 mL of the third intermediate solution.

S105: After the glue is made into a wire, the bristles are obtained. Wherein, the shaping of the glue into the wire comprises: S201: forming the glue into a wire by a wire drawing machine, then drying and shaping the wire to obtain a first original yarn; S202: rinsing the first original wire with distilled water to remove the result a porogen, followed by drying to obtain a second strand; S203: immersing the second strand in the second mixture, ultrasonically stirring, and then drying to obtain a bristled raw material yarn; wherein, the second mixture and the second raw yarn The mass ratio is (800 to 1200): 1; S204: the bristle raw material yarn is made into a toothbrush tuft, that is, the bristles are obtained.

Preferably, in the S101 to the S105, the operating temperature is 20 ° C to 28 ° C; in the S201 to S204, the drying temperature is 60 ° C to 65 ° C.

The operation principle and process of the self-cleaning degradable chitosan toothbrush of the invention are: in the process of brushing, the toothbrush is placed in the mouth after being drowned, and rubbed and rubbed on the surface of the tooth, and the bristles made of chitosan-polylactic acid copolymer are The wear resistance is very poor, so that it is constantly worn and produces tiny particles. The fine particles assist the bristles to rub the food residue and plaque, and clean the teeth and the mouth, replacing the friction agent in the toothpaste. The chitosan polylactic acid copolymer has many micropores inside, and the dandelion extract, the notoginseng extract and the sodium lauroyl sarcosinate are stored in these micropores, and the teeth are slowly released due to the dissolution of water and the impact of water flow during brushing. Come out, play the role of sterilization, hemostasis and foaming agent.

The following describes the specific embodiments:

Embodiment 1

The invention provides a self-cleaning degradable chitosan toothbrush, comprising: chitosan, polylactic acid solution and rosin solution. Wherein, the mass ratio of chitosan to the solute polylactic acid in the polylactic acid solution is 2.5:10, the polylactic acid solution is an acetic acid solution of polylactic acid having a mass percentage of 10%; the solute rosin and the polylactic acid solution in the rosin solution The mass ratio of the medium solute polylactic acid is 1:6, and the rosin solution is a rosin ethanol solution having a mass percent concentration of 9%.

According to the above raw material component, the self-cleaning degradable chitosan toothbrush is prepared by the preparation method provided by the invention:

S102: adding a rosin solution to the first intermediate solution and stirring for 15 minutes to obtain a second intermediate solution. Wherein, the preparation method of the rosin solution comprises: pulverizing the rosin, dissolving in absolute ethanol and stirring uniformly to obtain a rosin solution.

S103: adding a sodium hydroxide solution to the second intermediate solution to obtain a third intermediate solution. Wherein, the molar ratio of the solute sodium hydroxide in the sodium hydroxide solution to the acetic acid in the second intermediate solution is 1:1; the mass percentage concentration of the sodium hydroxide solution is 20%, and the droplet acceleration per minute is 50 drops.

S104: adding a porogen sodium chloride to the third intermediate solution, followed by standing to obtain a glue solution. Among them, the porogen was added in an amount of 2 g per 100 mL of the third intermediate solution.

S105: After the glue is made into a wire, the bristles are obtained. Wherein, the shaping of the glue into the wire comprises: S201: forming the glue into a wire by a wire drawing machine, then drying and shaping the wire to obtain a first original yarn; S202: rinsing the first original wire with distilled water to remove the result The pore agent is then dried to obtain a second raw yarn; S203: the second raw yarn is immersed in water, ultrasonically stirred for 10 minutes, and then dried to obtain a bristled raw material yarn.

Among them, in S101 to S105, the operating temperature is 25 ° C; in S201 to S204, the drying temperature is 60 ° C.

Embodiment 2

The present invention provides a self-cleaning degradable chitosan toothbrush comprising: a chitosan, a polylactic acid solution, and a rosin solution. Wherein, the mass ratio of chitosan to the solute polylactic acid in the polylactic acid solution is 1:10, the polylactic acid solution is an acetic acid solution of polylactic acid having a mass concentration of 4%; the solute rosin and the polylactic acid solution in the rosin solution The mass ratio of the medium solute polylactic acid was 1:15, and the rosin solution was a rosin ethanol solution having a mass percent concentration of 11%.

S102: adding a rosin solution to the first intermediate solution and stirring for 60 minutes to obtain a second intermediate solution. Wherein, the preparation method of the rosin solution comprises: pulverizing the rosin, dissolving in absolute ethanol and stirring uniformly to obtain a rosin solution.

S103: adding a sodium hydroxide solution to the second intermediate solution to obtain a third intermediate solution. Wherein, the molar ratio of the solute sodium hydroxide in the sodium hydroxide solution to the acetic acid in the second intermediate solution is 1:1; the mass percentage concentration of the sodium hydroxide solution is 15%, and the droplet acceleration per minute is 50 drops.

S104: adding a porogen potassium chloride to the third intermediate solution, and then standing to obtain a glue. Among them, the porogen was added in an amount of 3 g per 100 mL of the third intermediate solution.

S105: After the glue is made into a wire, the bristles are obtained. Wherein, the shaping of the glue into the wire comprises: S201: forming the glue into a wire by a wire drawing machine, then drying and shaping the wire to obtain a first original yarn; S202: rinsing the first original wire with distilled water to remove the result The pore agent is then dried to obtain a second raw yarn; S203: the second raw yarn is immersed in water, ultrasonically stirred for 20 minutes, and then dried to obtain a bristled raw material yarn.

Among them, in S101 to S105, the operating temperature is 25 ° C; in S201 to S204, the drying temperature is 65 ° C.

Embodiment 3

This embodiment is set on the basis of the first embodiment.

The invention provides a self-cleaning degradable chitosan toothbrush, comprising: chitosan, polylactic acid solution, rosin solution, dandelion, notoginsenoic acid and sodium lauroyl sarcosinate; wherein dandelion, notoginseng and lauroyl myosine The mass ratio of sodium is 1:0.3:1 in order. Wherein, the mass ratio of chitosan to the solute polylactic acid in the polylactic acid solution is 2.5:10, the polylactic acid solution is an acetic acid solution of polylactic acid having a mass concentration of 10%; the solute rosin and the polylactic acid solution in the rosin solution The mass ratio of the medium solute polylactic acid is 1:6, and the rosin solution is a rosin ethanol solution having a mass percent concentration of 9%. The preparation method of the second mixture comprises the following steps: S301: soaking dandelion and notoginseng with water for 36h, then filtering and collecting the filtrate; wherein, in kilograms of dandelion, the added mass of water is 20L; S302: sodium lauroyl sarcosinate The filtrate was added to the filtrate and stirred well to obtain a second mixture.

S105: After the glue is made into a wire, the bristles are obtained. Wherein, the shaping of the glue into the wire comprises: S201: forming the glue into a wire by a wire drawing machine, and then drying and shaping the wire to obtain a first original yarn; S202: rinsing the first original wire with distilled water to remove the result a porogen, followed by drying to obtain a second raw yarn; S203: immersing the second raw yarn in the second mixture, ultrasonically stirring for 10 minutes, and then drying to obtain a bristled raw material yarn; wherein, the second mixture and the second raw yarn The mass ratio is 1000:1.

Embodiment 4

This embodiment is set on the basis of the second embodiment.

The invention provides a self-cleaning degradable chitosan toothbrush, comprising: chitosan, polylactic acid solution, rosin solution, dandelion, notoginsenoic acid and sodium lauroyl sarcosinate; wherein dandelion, notoginseng and lauroyl myosine The mass ratio of sodium is 1.5:0.5:1 in order. Wherein, the mass ratio of chitosan to the solute polylactic acid in the polylactic acid solution is 1:10, the polylactic acid solution is an acetic acid solution of polylactic acid having a mass concentration of 4%; the solute rosin and the polylactic acid solution in the rosin solution The mass ratio of the medium solute polylactic acid was 1:15, and the rosin solution was a rosin ethanol solution having a mass percent concentration of 11%. The preparation method of the second mixture comprises the following steps: S301: soaking dandelion and notoginseng with water for 48 hours, then filtering and collecting the filtrate; wherein, for each kilogram of dandelion, the added mass of water is 20L; S302: sodium lauroyl sarcosinate The filtrate was added to the filtrate and stirred well to obtain a second mixture.

S104: adding a porogen potassium chloride and potassium chloride to the third intermediate solution, followed by standing to obtain a glue. Among them, the porogen potassium chloride and potassium chloride were added in an amount of 1.5 g per 100 mL of the third intermediate solution.

S105: After the glue is made into a wire, the bristles are obtained. Wherein, the shaping of the glue into the wire comprises: S201: forming the glue into a wire by a wire drawing machine, then drying and shaping the wire to obtain a first original yarn; S202: rinsing the first original wire with distilled water to remove the result a pore agent, followed by drying to obtain a second strand; S203: soaking the second strand in water, ultrasonically stirring for 20 min, and then drying to obtain a bristle strand; wherein, the mass ratio of the second mixture to the second strand It is 1000:1.

In addition, the self-cleaning degradable chitosan toothbrush obtained in each of the examples of the present invention was systematically evaluated for its efficacy by functional tests:

First, the bacteriostatic test

Test strains: Staphylococcus aureus, Lactobacillus, Salmonella typhi, Pseudomonas aeruginosa, Streptococcus mutans, and Helicobacter pylori. Preparation of bacterial solution: The slanted strain was inoculated into 20% bovine juice culture medium, cultured overnight at 37 ° C, and the bacterial liquid was diluted to 10 cfu/ml with 20% bovine juice culture medium, and immediately inoculated.

MIC measurement: serial dilution of the liquid tube was used, and a 20% bovine juice medium sample (each obtained by brushing each of the examples) was subjected to serial dilution. Add 1.0ml to the sterilized test tube, add 0.05ml standard fresh bacterial solution to each tube, set up the strain control and the vehicle control group, and incubate at 37 °C for 18-24 hours to observe the growth of the bacteria. The highest dilution for sterile growth is MIC, thereby evaluating the antibacterial effect of the self-cleaning degradable chitosan toothbrush prepared by the present invention on common strains in an in vitro bacteriostatic test with a minimum inhibitory concentration (MIC, mg/mL).

Table 1 Antibacterial effects of self-cleaning degradable chitosan toothbrush on common strains in each example

Second, clinical trials

500 volunteers aged between 18 and 60 years old (1:1 male to female) were recruited. Each volunteer was accompanied by different levels of oral problems, such as bleeding gums, unclear breath, toothache caused by dental caries, and oral ulcers caused by fire. Specifically, the patients are divided into 5 groups of 100 persons, and the self-cleaning degradable chitosan toothbrushes of the first to fourth embodiments are respectively tested in the first group to the fourth group, one time each morning and evening. 5 min each time; the fifth group was brushed with normal Colgate toothpaste. The toothbrush prepared by the self-cleaning degradable chitosan toothbrush provided by the present invention was continuously tested for 20 days, and the symptoms of each volunteer were recorded. The specific data are shown in Table 2.

The efficacy is judged as:

Significant effect: bleeding gums, unsatisfactory breath, toothache caused by dental caries, and oral ulcers caused by burning, significantly improved; improved: bleeding gums, bad breath, toothache caused by dental caries, and oral ulcers caused by fire Improved; invalid: no improvement in symptoms.

Table 2 Clinical effects of toothbrushes prepared from bristles in various examples on oral problems volunteers

Of course, in addition to the cases enumerated in the first to fourth embodiments, the kinds and weight percentages of other raw material components, conditions and parameters in the preparation process, and the like are also possible.

The toothbrush provided by the invention is convenient to use, environmentally friendly and does not need toothpaste during use; the self-cleaning degradable chitosan toothbrush of the invention actively wears during the brushing process, and the micro-particles generated during the abrasion process can effectively sterilize In addition, the bristles of the present invention have antibacterial and antibacterial effects, and the used bristles are exposed to the air for a long time without propagating harmful microorganisms such as bacteria, thereby better protecting oral hygiene and having wide application value.

In the description of the present invention, it is to be understood that the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying a relative importance or implicitly indicating the number of technical features indicated. Thus, features defining "first" and "second" may include one or more of the features either explicitly or implicitly. In the description of the present invention, the meaning of "a plurality" is two or more unless specifically and specifically defined.

In the description of the present specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" and the like means a specific feature described in connection with the embodiment or example. A structure, material or feature is included in at least one embodiment or example of the invention. In the present specification, the schematic representation of the above terms is not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in a suitable manner in any one or more embodiments or examples. In addition, various embodiments or examples described in the specification and features of various embodiments or examples may be combined and combined without departing from the scope of the invention.

Although the embodiments of the present invention have been shown and described, it is understood that the above-described embodiments are illustrative and are not to be construed as limiting the scope of the invention. The embodiments are subject to variations, modifications, substitutions and variations.

Claims

A toothbrush, characterized in that the toothbrush comprises bristles;

The raw material component of the bristles includes a first mixture; the first mixture includes a chitosan, a polylactic acid solution, and a rosin solution.
A toothbrush according to claim 1 wherein:

The mass ratio of the mass of the chitosan to the solute polylactic acid in the polylactic acid solution is (1 to 2.5): 10, the mass concentration of the polylactic acid solution is 4% to 10%, and the poly The lactic acid solution is an acetic acid solution of polylactic acid;

The mass ratio of the solute rosin in the rosin solution to the solute polylactic acid in the polylactic acid solution is 1: (6-15); and the rosin solution is a rosin ethanol solution, and the mass percentage of the rosin ethanol solution It is 9% to 11%.
The toothbrush according to claim 2, wherein the raw material component of the bristles further comprises a second mixture;

The second mixture comprises dandelion, notoginsenoyl and sodium lauroyl sarcosinate; wherein the mass ratio of the dandelion, the notoginseng and the sodium lauroyl sarcosinate is (1 to 1.5) in order: (0.3 ~0.5):1;

Wherein the preparation method of the second mixture comprises the following steps:

S301: immersing dandelion and notoginseng with water for 36h to 48h, then filtering and collecting the filtrate; wherein, for each kilogram of the dandelion, the water is added in a mass of 18L to 22L;

S302: adding sodium lauroyl sarcosinate to the filtrate obtained in the above S301, and stirring uniformly to obtain the second mixture.
The toothbrush according to any one of claims 1 to 3, wherein the toothbrush further comprises a handle and a brush head;

Wherein, the brush head is disposed at one end of the handle, and the brush head is a plate-like structure having an arc of 0.5 to 1.0 rad, a length of 2 to 3 cm, and a width of 1.5 to 2 cm, and the brush head is close to the curved shape. One side of the center of the circle is the front side, and the side away from the center of the arc is the back side;

The bristles are disposed on the front side of the brush head, and the length of the bristles is 0.5 to 0.8 cm;

The handle is curved, and the bending direction of the front half of the handle is the same as the bending direction of the brush head, and the bending direction of the rear half of the handle is opposite to the bending direction of the brush head, and the curvature of the handle is 0.8-1.2. Rad, length is 12 ~ 18cm.
A toothbrush according to claim 4, wherein:

Both the brush head and the handle are made of a degradable material.
The method of preparing a toothbrush according to any one of claims 1 to 5, comprising the steps of:

S101: dissolving chitosan in the polylactic acid solution to obtain a first intermediate solution;

S102: adding a rosin solution to the first intermediate solution and stirring uniformly to obtain a second intermediate solution;

S103: adding a sodium hydroxide solution to the second intermediate solution to obtain a third intermediate solution;

S104: adding a porogen to the third intermediate solution, and then standing to obtain a glue;

S105: Forming the glue into a wire and setting the bristles.
A method of preparing a toothbrush according to claim 6, wherein:

In the S102, the preparation method of the rosin solution comprises:

The rosin was ground, dissolved in absolute ethanol, and stirred to obtain a rosin solution.
A method of preparing a toothbrush according to claim 6, wherein:

In the S103, the molar ratio of the solute sodium hydroxide in the sodium hydroxide solution to the acetic acid in the second intermediate solution is 1:1; the mass percentage concentration of the sodium hydroxide solution is 15% to 25% And the drop rate per minute is less than 60 drops;

In the above S104, the porogen is sodium chloride and/or potassium chloride; and the porogen is added in an amount of 2 to 3 g per 100 mL of the third intermediate solution.
A method of preparing a toothbrush according to claim 6, wherein:

In the S105, the shaping of the glue liquid into a wire comprises:

S201: forming the glue into a wire by a wire drawing machine, and then drying and shaping the wire to obtain a first original yarn;

S202: rinsing the first strand with distilled water to remove the porogen, and then drying to obtain a second strand;

S203: soaking the second raw silk in the second mixture, ultrasonically stirring, and then drying to obtain a bristle raw material yarn; wherein the mass ratio of the second mixture to the second raw yarn is (800-1200) ):1;

S204: The bristles are made into a brush tuft to obtain the bristles.
A method of preparing a toothbrush according to claim 9, wherein:

In the above S101 to S105, the operating temperature is 20 ° C to 28 ° C; in the S201 to S204, the drying temperature is 60 ° C to 65 ° C.