JP2005139201A - Agent for dissolving dental calculi and dental caries - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a means conveniently and safely dissolving dental calculi and dental caries in a short time. <P>SOLUTION: This invention relates to the agent for dissolving dental calculi and/or dental caries, comprising one or more substances selected from the group consisting phosphoric acids, editic acid salts, tartaric acid, malic acid, citric acid. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a dissolving agent for tartar and / or caries.

  Tartar is a grayish white or yellowish or blackish brown calcification that deposits on the crown, exposed root surface, or restoration surface. Plaque (plaque) adheres to the surface of human teeth, but a reaction occurs in which inorganic salts easily adhere to the plaque, and calcification starts from the layer in contact with the tooth surface. As the plaque gets older and thicker, calcification proceeds, and new plaque adheres to the surface of the calcified plaque to cause calcification. This process is repeated to form tartar.

70-80% of the gingival marginal calculus is inorganic salts, mostly hydroxyapatite (Ca ₁₀ (PO ₄ ) ₆ (OH) ₂ ), but calcium phosphate, calcium carbonate, magnesium phosphate, etc. In some cases, it may contain dibasic calcium phosphate or tribasic calcium phosphate. The organic component contained in the calculus is a microbial cell, including the cell wall of Gram-positive bacteria and endotoxin which is an outer membrane component of Gram-negative bacteria. Plaque formation is more likely to proceed on the calculus surface than the smooth tooth surface, and the plaque adhering to the calculus stimulates the periodontal soft tissue and exerts its pathogenicity, so calculus removal in the prevention and treatment of periodontal disease is not It is important as one of the basic measures.

  Conventionally, a method of removing the tartar mechanically using a scaler or the like has been adopted, but the tartar is hard, so the treatment takes time, and the patient, dentist, or dental hygienist is burdened. Is a problem. As a means for chemically dissolving and removing tartar, for example, a tartar solubilizer described in Japanese Patent Publication No. 7-53653 is known, but its dissolving action is quite insufficient from a practical viewpoint. In addition, it is not used clinically in dentistry because of the irritation of drugs against periodontal soft tissue. Under such circumstances, development of a calculus dissolving agent that can dissolve calculus in a short time and does not cause irritation or injury to oral tissues such as periodontal soft tissues or dental tissues is eagerly desired. Although it has been reported that phytic acid is effective in inhibiting plaque formation (H. Nordbo, et al., J. Dent. Res., 51, 800, 1972), this document contains phytic acid. There is no suggestion or teaching that it has the action of dissolving tartar.

  On the other hand, when caries is carved out, it is a common treatment method to scrape off with a rotary cutting instrument. However, there is a problem of giving fear to the patient from the vibration and sound of the instrument and the generation of pain during the treatment. If the caries site is soft, it can be scratched with a dental instrument called an excavator, but it is difficult to scratch completely. Recently, a method of dissolving with a caries solubilizer developed in Sweden and scraping with a special instrument has been used (trade name “Karisolve”, manufactured by Medi Team, Patent No. 2728306). However, carisolve has a problem that it has a weak softening ability and takes a long time for treatment. Furthermore, there are also disadvantages that a mixing step is required before use, the operation is complicated, and the storage stability is poor. Therefore, it is desired to provide a caries solubilizing agent that can easily dissolve and soften carious portions, has excellent storage stability, and can be treated by a simple operation.

  The subject of this invention is providing the calculus and / or caries part dissolving agent which can melt | dissolve a calculus and / or caries part easily in a short time. Another object of the present invention is to dissolve calculus and / or caries part having the above-mentioned characteristics and excellent in storage stability without causing irritation or injury to oral tissues such as periodontal soft tissues or dental tissues. It is to provide an agent.

  As a result of intensive studies to solve the above problems, the present inventors have found that inositol phosphates, polyphenols, phosphates, edetates, tartaric acid, malic acid, citric acid, and glycolic acid It has been found that one or more selected substances have excellent properties as a solubilizing agent for tartar and / or caries, and the present invention has been completed.

  That is, according to the present invention, one or more substances selected from the group consisting of inositol phosphates, polyphenols, phosphates, edetates, tartaric acid, malic acid, citric acid, and glycolic acid are used as active ingredients. A dissolution agent for tartar and / or caries is included.

  According to a preferred embodiment of the present invention, the above-mentioned calculus and / or caries part solubilizer containing phytic acid as an active ingredient; the group consisting of red perilla polyphenol, cassis polyphenol, hop polyphenol, sugar cane polyphenol, and disodium edetate Said tartar and / or caries part solubilizer containing one or more substances selected from the above as an active ingredient; said tartar and / or caries part solubilizer further containing an inorganic metal salt; inorganic metal The calculus and / or caries lytic agent as described above, wherein the salt is sodium chloride; the calculus and / or caries lytic agent as described above further comprising a bacterial degrading enzyme; the bacterial degrading enzyme as egg white lysozyme, pectinase, protease, and Dissolution of the above calculus and / or caries that is one or more bacterial degradation enzymes selected from the group consisting of alginate lyase The above-mentioned tartar and / or carious part solubilizer further containing a surfactant; The above-mentioned tartar and / or carious part solubilizer, whose surfactant is cetrimide; used for humans or non-human mammals The above-mentioned calculus and / or caries part dissolving agent is provided.

  From another point of view, according to the present invention, there is provided a method for dissolving tartar and / or caries, comprising inositol phosphates, polyphenols, phosphates, edetates, tartaric acid, malic acid, citric acid, and glycol. There is provided a method including a step of bringing one or more substances selected from the group consisting of acids into contact with tartar and / or caries. According to a preferred embodiment of this method, there is provided a method including a step of applying a solution containing the above substance to tartar and / or caries. Further, from another viewpoint, inositol phosphates, polyphenols, phosphates, edetates, tartaric acid, malic acid, citric acid, and the like for the production of the above-mentioned calculus and / or caries part dissolving agent, and The use of one or more substances selected from the group consisting of glycolic acid is also provided by the present invention.

  The calculus and / or caries dissolution agent of the present invention has an extremely excellent calculus and / or caries dissolution action, and is characterized in that it can be easily treated without the need for mixing and preparing drugs.

  The active ingredient of the calculus and / or caries dissolution agent of the present invention is selected from the group consisting of inositol phosphates, polyphenols, phosphates, edetates, tartaric acid, malic acid, citric acid, and glycolic acid One kind or two or more kinds of substances can be used. Preferably, one or two or more substances selected from the group consisting of inositol phosphates, polyphenols, and edetates can be used.

  The stereochemistry of the inositol moiety of the inositol phosphate is not particularly limited. Etc. are preferable. The number of phosphate esters of inositol phosphate is not particularly limited, but hexaphosphate is preferred. Among inositol phosphates, meso-inositol hexaphosphate (phytic acid) is preferable. As an active ingredient of the calculus dissolution agent of the present invention, two or more inositol phosphates may be used in combination.

  Inositol phosphates are readily available to those skilled in the art. For example, phytic acid is a substance contained in seeds and cereals, particularly rice bran, and is used in the food and medical fields, and a commercially available product is readily available. For example, since products with a content of 48 to 52% are commercially available as food improvers from Daiichi Pharmaceutical Co., Ltd. and Tsukino Food Industry Co., Ltd., these products can be used as they are as calculus solubilizers of the present invention, It can be used after appropriately diluted with a buffer or the like.

  Although the kind of polyphenol is not specifically limited, For example, red perilla polyphenol, cassis polyphenol, tea polyphenol, buckwheat polyphenol, cranberry polyphenol, grape seed polyphenol, rubini polyphenol, sugar cane polyphenol, hop polyphenol, etc. can be used. Of these, red perilla polyphenols rich in rosmarinic acid or cassis polyphenols rich in anthocyanins are preferred. Polyphenols are readily available to those skilled in the art. For example, red perilla polyphenol is a substance contained in red perilla and cassis polyphenol is a substance contained in cassis, and is used as a preferable substance for maintaining health in the food field, and a commercially available product is readily available. For example, red perilla polyphenol is commercially available as a food improver from Meiji Seika Co., Ltd. As polyphenols, purified or roughly purified polyphenols may be used, but natural products and natural product extracts containing a large amount of polyphenols may be used as they are. For example, a purple pigment containing polyphenols may be used. It has been elucidated that polyphenols have excellent functions such as removal of active oxygen in the living body and improvement of blood flow and relaxation effect. It has been confirmed that anthocyanins in cassis polyphenols have the effect of improving blood flow in capillaries, and have the effect of increasing the regeneration rate of rhodopsin, a photoreceptor substance in the retina, and lowering the light threshold. As for hop polyphenols, there are reports on the effect of suppressing plaque adhesion (Shinada et al., Journal of Oral Hygiene, 53 (4), Abstract No. 03-1E0920, 2003). However, there has been no report that polyphenols can dissolve calculus and / or caries.

  Edetates are readily available to those skilled in the art. Examples of edetates include disodium edetate, trisodium edetate, and tetrasodium edetate. Of these, edetate disodium is preferred. For example, disodium edetate is a so-called chelating agent that binds the metal ion of a heavy metal compound into the molecule to form a stable cyclic compound and deactivates it, and has been conventionally used as an antidote for heavy metal poisoning. Using this property, it may be used in the food field for the purpose of preventing discoloration and preventing oxidation. However, there has been no report that edetates can dissolve calculus and / or caries. As phosphoric acid, phosphoric acid, polyphosphoric acid, pyrophosphoric acid, etc. can be used, and phosphoric acid is preferable.

  Generally, the calculus or caries part dissolving agent of the present invention can be used in the form of a solution. For example, one or more substances selected from the group consisting of inositol phosphates, polyphenols, phosphates, edetates, tartaric acid, malic acid, citric acid, and glycolic acid, preferably phytic acid, red shiso Preparing an aqueous solution containing one or more substances selected from the group consisting of polyphenols, cassis polyphenols, and disodium edetate in a proportion of about 5 to 40% by weight, and applying the solution to tartar or caries. Can do. Moreover, when using phosphoric acid as an active ingredient of the calculus and / or caries part of the present invention, the concentration of phosphoric acid is preferably 30% by weight or less, more preferably based on the total weight of the composition. It is about 15% by weight or less, particularly preferably about 10% by weight. Further, when tartaric acid, malic acid, citric acid, or glycolic acid is used as an active ingredient of the calculus and / or caries part of the present invention, the concentration of these substances is based on the total weight of the composition. Preferably it is 30 weight% or less, More preferably, it is 15 weight% or less, Most preferably, it is about 10 weight%. When the calculus or caries part dissolving agent of the present invention is prepared as an aqueous solution, a small amount of an organic solvent mixed with water may be added as necessary. Examples of the organic solvent include ethanol, glycerin, ethylene glycol, and the like.

  The calculus and / or caries part dissolving agent of the present invention is blended with one or more inorganic metal salts selected from the group consisting of inorganic metal salts, preferably alkali metal and alkaline earth metal salts. Can do. Sodium chloride is preferable as the inorganic metal salt. The compounding amount of the inorganic metal salt is not particularly limited. For example, the weight of a substance selected from the group consisting of inositol phosphates, polyphenols, phosphates, edetates, tartaric acid, malic acid, citric acid, and glycolic acid ( When two or more kinds of substances are included, the total weight is about 10 to 50 weight percent. However, the amount of the inorganic metal salt can be appropriately increased or decreased.

  Moreover, you may add a bacteriolytic enzyme and / or surfactant to the tartar and / or caries part dissolving agent of this invention. Bacteriolytic enzymes include, for example, egg white lysozyme, pectinase (for example, “Pectinase Nagase” Nagase ChemteX Co., Ltd.), protease (for example, “Biolase Conk” Nagase Chemtex Co., Ltd.), alginate lyase (eg, “alginate”). Lyase S "Nagase ChemteX Corporation etc.) etc. can be used. Egg white lysozyme is an enzyme having an action of lysing bacterial cell membranes and exists in chicken eggs. It is a basic protein rich in arginine, aspartic acid, and tryptophan as a characteristic of the constituent amino acids. As the surfactant, for example, cetrimide can be used. Cetrimide is a surfactant mainly composed of myristyltrimethylammonium bromide, which is a quaternary ammonium salt, and is generally used as a disinfectant and disinfectant, and is added to some disinfectants.

  The tartar and / or caries part solubilizer of the present invention can be used as a semi-solid having gel properties and thixotropic properties by adding an appropriate additive for pharmaceutical preparation such as a gelling agent as required. It can also be prepared in the form of an ointment, or it can be formulated in a dentifrice or in a solution for oral cleansing (eg, dental rinse or mouthwash) used before brushing. In the calculus or caries part dissolving agent of the present invention, one or more kinds of pH regulators, buffer materials, preservatives, osmotic pressure regulators, thickeners, pigments and the like generally used as additives for pharmaceutical preparations are used. Two or more kinds can be blended. Furthermore, active zeolite, iron oxide, quick lime, etc. can be blended with the tartar and / or caries part solubilizer of the present invention and used as a hot melt, for example, a dentifrice provided as a thermal dentifrice. It is also preferable to add the tartar and / or caries part dissolving agent of the present invention to (for example, a dentifrice of “Check Periodontal Care Series” of Kao Corporation in which active zeolite is blended).

  For example, when preparing as a dentifrice, the components commonly used in dentifrice include, for example, calcium hydrogen phosphate, aluminum hydroxide, calcium carbonate, glycerin, sorbit, sodium laurate, sodium carboxymethylcellulose, sodium alginate, carrageenan , Saccharin sodium, menthol, mint and other basic ingredients or medicinal ingredients such as sodium monofluorophosphate, sodium fluoride, cetylpyridinium chloride, tranexamic acid, dipotassium glutyrrhizinate, β-glutyrrhetinic acid, chlorhexidine hydrochloride, acetic acid- dl-α-tocopherol, sodium chloride, triclosan, dextrose, sodium polyphosphate, aluminum lactate, potassium nitrate, polyethylene glycol, etc. Min can be used, without being limited thereto. When preparing as a dental rinse, the components commonly used in the manufacture of dental rinses include, for example, ethanol, thymol, 1,8-cineole, methyl salicylate, l-menthol, benzoic acid, polyoxyethylene polyoxypropylene glycol, Components such as sodium benzoate can be used, but are not limited to these.

  The mode of use of the calculus and / or caries part solubilizer of the present invention is not particularly limited, but when preparing as a solution-like preparation, absorbent cotton or cotton swab is impregnated with the solubilizer and, if necessary, tweezers etc What is necessary is just to apply | coat to a tartar or a caries part using a suitable instrument. After application, the calculus is partially or wholly dissolved within a few minutes, and the calculus is easily removed from the tooth surface. The carious portion dissolves in part or all in a few minutes and can be completely scraped off. After application, the application portion may be heated using a visible light, laser light, or the like used to initiate the polymerization of the dental resin. Alternatively, the preparation may be preliminarily heated and applied using an instrument for heating a mosquito catching mat or a liquid. By heating, the dissolving action can be promoted.

  As used herein, “dissolution of tartar and / or carious part” or its synonym is not only a phenomenon in which tartar and / or carious part dissolves macroscopically, but also the microscopic condition of tartar and / or carious part. It must be interpreted in the broadest sense, including the phenomenon that the tartar and / or carious part softens due to chemical dissolution, and should not be limitedly interpreted in any way. For example, the concept of calculus or caries dissolution dissolves by removing and removing calculus or caries at the initial stage of formation to suppress calculus formation or caries formation. Moreover, the tartar and / or caries part dissolving agent of the present invention can be used for humans or mammals other than humans. For example, it can also be used as a tartar solubilizer for animals.

EXAMPLES Hereinafter, although an Example demonstrates this invention further more concretely, the scope of the present invention is not limited to the following Example.
Example 1
After washing the tartar collected from the oral cavity with water, the tartar obtained by wiping with Kimwipe 3.0 mg of phytic acid (Daiichi Pharmaceutical Co., Ltd., 48-52% content prepared as a 15% aqueous solution) 0.5 g It was immersed in 1 ml of an aqueous solution containing 5 minutes or 10 minutes. The treated tartar was washed with water, wiped with Kimwipe and measured for weight, which was 2.6 mg and 2.1 mg, respectively. A marked decrease in tartar weight was observed.

Example 2
After washing the tartar collected from the oral cavity with water, the tartar obtained by wiping with Kimwipe 3.0 mg of phytic acid (Daiichi Pharmaceutical Co., Ltd., 48-52% content prepared as a 15% aqueous solution) 0.5 g And it was immersed in 1 ml of an aqueous solution containing 0.1 g of sodium chloride for 5 minutes or 10 minutes. The treated calculus was washed with water, wiped with Kimwipe and measured for weight, which was 2.4 mg and 1.4 mg, respectively.

Example 3
The tartar collected from the oral cavity was washed with water, and 0.6 mg of tartar obtained by wiping the water with Kimwipe was immersed in 1 ml of red shiso polyphenol (manufactured by Meiji Seika Co., Ltd. as a 5% aqueous solution) for 105 minutes. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured. The result was 0.3 mg, and a significant decrease in tartar weight was observed.

Example 4
After the tartar collected from the oral cavity was washed with water, 1.0 mg of tartar obtained by wiping the water with Kimwipe was immersed in 1 ml of cassis polyphenol (manufactured by Meiji Seika Co., Ltd. as a 20% aqueous solution) for 90 minutes. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured. As a result, it was 0.5 mg, and a significant decrease in tartar weight was observed.

Example 5
After washing the tartar collected from the mouth with water, 1.2 mg of tartar obtained by wiping the water with Kimwipe is 5% each of red shiso polyphenol (Meiji Seika Co., Ltd.) and phytic acid (Daiichi Pharmaceutical Co., Ltd.), It was immersed for 7 minutes in 1 ml of an aqueous solution prepared to 12.5%. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured to be 0.6 mg. A significant decrease in tartar weight was observed.

Example 6
After washing the tartar collected from the oral cavity, calculus 1.2mg obtained by wiping water with Kimwipe is red shiso polyphenol (Meiji Seika Co., Ltd.), phytic acid (Daiichi Pharmaceutical Co., Ltd.), and sodium chloride 5 %, 12.5%, and 16.6% of an aqueous solution prepared for 4 minutes 30 seconds. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured to be 0.6 mg. A significant decrease in tartar weight was observed.

Example 7
After washing tartar collected from the oral cavity with water, calculus polyphenol (Meiji Seika Co., Ltd.), phytic acid (Daiichi Pharmaceutical Co., Ltd.) and sodium chloride 5% each obtained by wiping water with Kimwipe 1.2mg The sample was immersed in 1 ml of an aqueous solution prepared to 12.5% and 16.6% for 4 minutes and 30 seconds. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured to be 0.6 mg. A significant decrease in tartar weight was observed.

Example 8
The tartar collected from the oral cavity was washed with water, and then 0.50 mg of tartar obtained by wiping the water with Kimwipe was immersed in 1 ml of an aqueous solution prepared with 14.3% disodium edetate for 44 minutes. The treated tartar was washed with water, wiped with Kimwipe and measured for weight, and it was 0.25 mg. A significant decrease in tartar weight was observed.

Example 9
After the tartar collected from the oral cavity was washed with water, 1.12 mg of tartar obtained by wiping with Kimwipe was immersed in 1 ml of an aqueous solution prepared with disodium edetate and cetrimide at 14.3% and 0.084%, respectively, for 40 minutes. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured. As a result, it was 0.56 mg, and a significant decrease in tartar weight was observed.

Example 10
After the tartar collected from the oral cavity was washed with water, 0.79 mg of tartar obtained by wiping water with Kimwipe was immersed in 1 ml of an aqueous solution prepared with disodium edetate and egg white lysozyme at 14.3% and 10%, respectively, for 40 minutes. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured. As a result, it was 0.40 mg, and a significant decrease in tartar weight was observed.

Example 11
After the tartar collected from the oral cavity was washed with water, 1.2 mg of tartar obtained by wiping with Kimwipe was immersed in 1 ml of a 10% aqueous solution of phosphoric acid for 7 minutes and 30 seconds. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured to be 0.6 mg. A significant decrease in tartar weight was observed.

Example 12
After the tartar collected from the oral cavity was washed with water, 1.4 mg of tartar obtained by wiping the water with Kimwipe was immersed in 1 ml of 2% aqueous solution of phosphoric acid for 8 minutes and 30 seconds. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured. As a result, it was 0.7 mg, and a significant decrease in tartar weight was observed.

Example 13
After the tartar collected from the oral cavity was washed with water, 1.5 mg of tartar obtained by wiping the water with Kimwipe was immersed in 1 ml of a 10% aqueous solution of polyphosphoric acid for 7 minutes and 30 seconds. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured. As a result, it was 0.7 mg, and a significant decrease in tartar weight was observed.

Example 14
After the tartar collected from the oral cavity was washed with water, 2.2 mg of tartar obtained by wiping water with Kimwipe was immersed in 1 ml of a 10% aqueous solution of pyrophosphate for 7 minutes. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured to find 1.1 mg. A significant decrease in tartar weight was observed.

Example 15
The tartar collected from the oral cavity was washed with water, and then 0.8 mg of tartar obtained by wiping the water with Kimwipe was immersed in 1 ml of a 10% tartaric acid aqueous solution for 5 minutes. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured. As a result, it was 0.4 mg, and a significant decrease in tartar weight was observed.

Example 16
The tartar collected from the oral cavity was washed with water, and then 1.3 mg of tartar obtained by wiping the water with Kimwipe was immersed in 1 ml of 10% aqueous citric acid solution for 13 minutes. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured. As a result, it was 0.65 mg, and a significant decrease in tartar weight was observed.

Example 17
The tartar collected from the oral cavity was washed with water, and then 1.2 mg of tartar obtained by wiping water with Kimwipe was immersed in 1 ml of a 10% malic acid aqueous solution for 13 minutes. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured to be 0.6 mg. A significant decrease in tartar weight was observed.

Example 18
The tartar collected from the oral cavity was washed with water, and then 0.9 mg of tartar obtained by wiping the water with Kimwipe was immersed in 1 ml of a 10% aqueous solution of glycolic acid for 9 minutes. The treated tartar was washed with water, wiped with Kimwipe, and the weight was measured. As a result, it was 0.5 mg, and a significant decrease in tartar weight was observed.

Example 19
For teeth with caries extracted from the oral cavity, red perilla polyphenol (Meiji Seika Co., Ltd.), phytic acid (Daiichi Pharmaceutical Co., Ltd.), fine particle silica (2%, 12.5%, 10 respectively) %) Was allowed to adhere to the gel prepared by waiting for 5 minutes, and lightly removed with an excavator (see FIG. 1: right side of tooth after “test”). The left side of the photograph is lightly removed with an excavator as a control (see FIG. 1). Apparently the right side of the tooth was removed cleanly, but the left side of the control remained black and hard and could not be completely removed.

  The calculus and / or caries dissolution agent of the present invention has an extremely excellent calculus and / or caries dissolution action, and is characterized in that it can be easily treated without the need for mixing and preparing drugs. In addition, there is almost no irritation or injury to oral tissues such as periodontal soft tissue or tooth tissue, and it is excellent in stability, so it can be used as a safe solubilizer for tartar and / or caries in the dental field. It can be used suitably.

FIG. 1 is a view showing the effect of the caries dissolution agent of the present invention. In the figure, “before test” is the tooth before treatment with caries solubilizer, and “after test” is the tooth after treatment with caries solubilizer and after removing caries with excavator (tooth On the right).

Claims (8)

A solubilizing agent for tartar and / or caries that contains as an active ingredient one or more substances selected from the group consisting of phosphoric acids, edetates, tartaric acid, malic acid, and citric acid. The dissolution agent for tartar and / or carious portion according to claim 1, further comprising an inorganic metal salt. The dissolution agent for tartar and / or carious portion according to claim 2, wherein the inorganic metal salt is sodium chloride. The calculus and / or caries part dissolving agent according to any one of claims 1 to 3, further comprising a bacterial degrading enzyme. The calculus and / or caries part solubilizer according to claim 4, wherein the bacterial degrading enzyme is one or more bacterial degrading enzymes selected from the group consisting of egg white lysozyme, pectinase, protease, and alginate lyase. The calculus and / or carious part dissolving agent according to any one of claims 1 to 5, further comprising a surfactant. The calculus and / or carious part dissolution agent according to claim 6, wherein the surfactant is cetrimide. The calculus and / or caries part dissolving agent according to any one of claims 1 to 7, which is used for humans or mammals other than humans.