WO2018210981A1 - Solid particles - Google Patents

Solid particles Download PDF

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Publication number
WO2018210981A1
WO2018210981A1 PCT/EP2018/062831 EP2018062831W WO2018210981A1 WO 2018210981 A1 WO2018210981 A1 WO 2018210981A1 EP 2018062831 W EP2018062831 W EP 2018062831W WO 2018210981 A1 WO2018210981 A1 WO 2018210981A1
Authority
WO
WIPO (PCT)
Prior art keywords
solid particles
vitamin
total weight
derivatives
gum
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2018/062831
Other languages
English (en)
French (fr)
Inventor
Jihane Achkar
Bernd Schlegel
Loni Schweikert
Olivia Brigitte VIDONI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DSM IP Assets BV
Original Assignee
DSM IP Assets BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM IP Assets BV filed Critical DSM IP Assets BV
Priority to EP18723547.8A priority Critical patent/EP3624784A1/en
Priority to US16/613,915 priority patent/US20200085777A1/en
Priority to BR112019023437-3A priority patent/BR112019023437A2/pt
Priority to KR1020197033613A priority patent/KR20200007822A/ko
Priority to JP2019554733A priority patent/JP2020520894A/ja
Priority to CN201880032301.9A priority patent/CN110621308A/zh
Publication of WO2018210981A1 publication Critical patent/WO2018210981A1/en
Anticipated expiration legal-status Critical
Priority to JP2022169709A priority patent/JP7506726B2/ja
Priority to US18/921,898 priority patent/US20250041260A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/50—Polysaccharides, gums
    • A23V2250/51—Polysaccharide
    • A23V2250/5118—Starch
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/60—Sugars, e.g. mono-, di-, tri-, tetra-saccharides
    • A23V2250/636—Trehalose
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2250/00—Food ingredients
    • A23V2250/70—Vitamins
    • A23V2250/702—Vitamin A

Definitions

  • the present patent application relates to new solid particles comprising a high amount of vitamin A and/or its derivatives (such as vitamin A acetate and vitamin A palmitate) and which do not comprise any antioxidants.
  • the new particles are very stable (against oxidation).
  • Compressed tablets are a very useful way for administering fat-soluble vitamins. They are easy to be consumed, easy to store and good to handle.
  • the present invention relates to solid particles (SP) comprising
  • solid particles do not comprise any antioxidants.
  • the present invention relates to solid particles (SP') comprising
  • solid particles do not comprise any antioxidants.
  • These solid particles show better storage stability (of the vitamin A and/or its derivatives (such as vitamin A acetate and vitamin A palmitate)) per se as well when compressed into tablets.
  • Antioxidants are a class of preservatives, which includes natural antioxidants (such as ascorbic acid, and tocopherols), as well as synthetic antioxidants (such as propyl gallate, tertiary butylhydroquinone, butylated hydroxyanisole and butylated hydroxytoluene).
  • natural antioxidants such as ascorbic acid, and tocopherols
  • synthetic antioxidants such as propyl gallate, tertiary butylhydroquinone, butylated hydroxyanisole and butylated hydroxytoluene.
  • the present invention relates to solid particles (SP1 ) consisting of
  • the present invention relates to solid particles (SPV) consisting of (i) at least 22 weight-% (wt-%), based on the total weight of the solid particles, of vitamin A acetate and vitamin A palmitate,
  • non-reducing sugars are non-reducing disaccharides; more preferably sucrose and/or trehalose, most preferred is trehalose.
  • Sucrose is a disaccharide combination of the monosaccharides glucose and fructose with the formula C12H22O11. It is commercially available from many suppliers. Sucrose is often extracted and refined from either cane or beet sugar for human
  • Trehalose also known as mycose or tremalose, is a natural alpha-linked disaccharide formed by an a,a-1 ,1 -glucoside bond between two a-glucose units.
  • trehalose is derived from corn starch.
  • biological pathways for trehalose biosynthesis There are known biological pathways for trehalose biosynthesis.
  • Trehalose is available commercially from various suppliers.
  • the amount of non-reducing sugar in the solid particles is from 5 - 55 weight-% (wt- %), based on the total weight of the solid particles.
  • wt- % weight-%
  • the present invention relates to solid particles (SP2), which are solid particles (SP), (SP'), (SP1 ) or (SPV) comprising 5 - 55 wt- %, based on the total weight of the solid particles, of at least one non-reducing sugar. Therefore the present invention relates to solid particles (SP3), which are solid particles (SP), (SP"), (SP1 ), (SP1 ') or (SP2) comprising 10 - 50 wt- %, based on the total weight of the solid particles, of at least one non-reducing sugar. Therefore the present invention relates to solid particles (SP4), which are solid particles (SP) or (SP') comprising 15 - 45 wt- %, based on the total weight of the solid particles, of at least one non-reducing sugar.
  • the solid particles according to the present invention comprise usually comprise 22 - 75 wt-%, based on the total weight of the solid particles, of vitamin A and/or its derivatives (such as vitamin A acetate and vitamin A palmitate), preferably, 25 - 65 wt-%, based on the total weight of the solid particles.
  • the present invention relates to solid particles (SP5), which are solid particles (SP), (SP'), (SP1 ), (SPT), (SP2), (SP3) or (SP4), wherein the solid particles comprise 22 - 75 wt-%, based on the total weight of the solid particles, of vitamin A and/or its derivatives.
  • the present invention relates to solid particles (SP6), which are solid particles (SP), (SP'), (SP1 ), (SP1 '), (SP2), (SP3), (SP4) or (SP5), wherein the solid particles comprise 25- 65 wt-%, based on the total weight of the solid particles, of vitamin A and/or its derivatives.
  • the solid particles according to the present invention comprise at least one emulsifier. Any commonly known and used emulsifier can be used. A single emulsifier as well as a mixture of emulsifiers can be used.
  • More preferred emulsifiers are modified (food) starches, polysaccharide gums and plant proteins.
  • the starches can be modified physically and chemically.
  • Pregelatinized starches are examples of physically modified starches.
  • Acidic modified, oxidized, cross- linked, starch esters, starch ethers and cationic starches are examples of chemically modified starches.
  • the amount of the emulsifier(s) in the solid particles is usually from 20 - 70 wt-%, based on the total weight of the solid particles; preferably 25 - 65 wt-%, based on the total weight of the solid particles.
  • solid particles which are solid particles (SP), (SP'), (SP1 ), (SPT), (SP2), (SP3), (SP4), (SP5) or (SP6), wherein the at least emulsifier is chosen from the group consisting of modified (food) starches, ascorbyl palmitate, pectin, alginate, carrageenan, furcellaran, dextrin derivatives, celluloses and cellulose derivatives (e.g.
  • the present invention relates to solid particles (SP7'), which are solid particles (SP), (SP'), (SP1 ), (SPT), (SP2), (SP3), (SP4), (SP5) or (SP6), wherein the at least emulsifier is not derived from an animal source. Therefore the present invention relates to solid particles (SP7"), which are solid particles (SP), (SP'), (SP1 ), (SPT), (SP2), (SP3), (SP4), (SP5) or (SP6), wherein the at least emulsifier is chosen from the group consisting of modified (food) starches, polysaccharide gums and plant proteins.
  • solid particles which are solid particles (SP), (SP'), (SP1 ), (SP1 '), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7') or (SP7"), wherein the amount of the emulsifier(s) in the solid particles is 20 - 70 wt-%, based on the total weight of the solid particles.
  • solid particles which are solid particles (SP), (SP'), (SP1 ), (SP1 '), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7') or (SP7"), wherein the amount of the emulsifier(s) in the solid particles is 25 - 65 wt-%, based on the total weight of the solid particles.
  • the solid particles can comprise further ingredients (auxiliary agents).
  • Such auxiliary agents are for example gel-forming agents (such as xanthan gum or gellan gum); humectants (such as glycerine, sorbitol, polyethylene glycol); dyes; fragrances; fillers and buffers.
  • gel-forming agents such as xanthan gum or gellan gum
  • humectants such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbitol
  • auxiliary agents can be useful for the solid particles, for their production, for the final product (for what the solid particles used) and/or for the production of the final product.
  • These compounds can optionally be used in an amount of up to 15 wt-%, based on the solid particles.
  • solid particles which are solid particles (SP), (SP'), (SP1 ), (SPT), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7'), (SP7"), (SP8) or (SP9), comprising up to 15 wt-%, based on the solid particles, of at least one auxiliary agents.
  • the present invention relates to solid particles (SP1 1 ), which are solid particles (SP10), wherein the auxiliary agent (or auxiliary agents) is chosen from the group consisting of gel-forming agents (such as xanthan gum, gellan gum); humectants (such as glycerine, sorbitol, polyethylene glycol); dyes; fragrances; fillers and buffers.
  • the auxiliary agent or auxiliary agents
  • gel-forming agents such as xanthan gum, gellan gum
  • humectants such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbitol, polyethylene glycol
  • dyes such as glycerine, sorbito
  • the amount of the powder (especially of corn starch) can be up to 15 wt-%, based on the total weight of the powder coated particles. Usually the content of the powder coating is kept as low as possible, so that another coating layer can be created.
  • This layer can be of any known and used coating material.
  • a suitable size of the solid particles of the present invention is between 50 - ⁇ ⁇ (preferably 100 - 800 ⁇ ); the size is defined by the diameter of the longest dimension of the particle and measured by commonly known method (like laser diffraction)
  • All particle sizes of the solid particles according to the present invention are determined by laser diffraction technique using a "Mastersizer 3000" of Malvern Instruments Ltd., UK. Further information on this particle size characterization method can e.g. be found in "Basic principles of particle size analytics", Dr. Alan Rawle, Malvern Instruments Limited, Enigma Business Part, Grovewood Road, Malvern, Worcestershire, WR14 1 XZ, UK and the "Manual of Malvern particle size analyzer". Particular reference is made to the user manual number MAN 0096, Issue 1 .0, Nov. 1994.
  • particle sizes referring to the coarse particles of the solid particles according to the present invention are Dv90 values (volume diameter, 90% of the population resides below this point, and 10% resides above this point) determined by laser diffraction.
  • the particle size can be determined in the dry form, i.e. as powder or in suspension.
  • the particle size of the solid particles according to the present invention is determined as powder.
  • the distribution of the particle size of the solid particles is also no essential feature of the present invention.
  • the shape of the solid particles is also not an essential feature of the present invention.
  • the shape can be sphere-like or any other form (also mixtures of shapes). Usually and preferably, the particles are sphere-like.
  • the particles can be produced by any commonly known process, which are used to produce such particles (spray drying, spray chilling, etc.).
  • the process of coating such small particles is well known. It is usually done by fluidized bed spray granulation, film coating or wet granulation.
  • the solid particles according to the present invention are mainly used for producing compressed tablet.
  • the present invention relates to the use of at least one solid particle (SP), (SP'), (SP1 ), (SPT), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7'), (SP7"), (SP8), (SP9), (SP10) and/or (SP1 1 ) in the production of compressed tablets.
  • SP solid particle
  • the pressure, which is used to producing tablets, is at least 5 kN
  • the pressure which is used to producing tablets, is usually between 5 and 40kN, preferably between 10 - 40 kN, more preferably between 5 - 40 kN.
  • the present invention relates to the process (P) of producing compressed tables wherein at least one solid particle (SP), (SP'), (SP1 ), (SPT), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7'), (SP7"), (SP8), (SP9), (SP10) and/or (SP1 1 ) are compressed with at pressure of at least 5 kN.
  • SP solid particle
  • the present invention relates to the process ( ⁇ ') of producing compressed tables wherein at least one solid particle (SP), (SP'), (SP1 ), (SPT), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7'), (SP7"), (SP8), (SP9), (SP10) and/or (SP1 1 ) are compressed with at pressure of between 5 and 40kN,
  • the present invention relates to the process (P") of producing compressed tables wherein at least one solid particle (SP), (SP'), (SP1 ), (SPV), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7'), (SP7"), (SP8), (SP9), (SP10) and/or (SP1 1 ) are compressed with at pressure of between 10 - 40 kN.
  • SP solid particle
  • the present invention relates to the process ( ⁇ "') of producing compressed tables wherein at least one solid particle ((SP), (SP'), (SP1 ), (SPV), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7'), (SP7"), (SP8), (SP9), (SP10) and/or (SP1 1 ) are compressed with at pressure of between 15 - 40 kN.
  • at least one solid particle ((SP), (SP'), (SP1 ), (SPV), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7'), (SP7"), (SP8), (SP9), (SP10) and/or (SP1 1 ) are compressed with at pressure of between 15 - 40 kN.
  • the present invention relates to the process (P1 ), which is process (P), ( ⁇ '), (P") or ( ⁇ "'), wherein at least one further ingredient is added.
  • the tablet can be a dietary supplement or a pharmaceutical product. This depends what is added to the compressed tablets additionally.
  • the present invention also relates to compressed tablets comprising at least one solid particle (SP), (SP'), (SP1 ), (SP1 '), (SP2), (SP3), (SP4), (SP5), (SP6), (SP7), (SP7'), (SP7"), (SP8), (SP9), (SP10) and/or (SP1 1 ).
  • Example 2 Composition with an antioxidant (Comparison Example) The same procedure as described hereinbefore was followed using 190.82g of an oil mixture (188.78g vitamin A acetate, 1 .04g BHT) and using less modified food starch (316.75g)) Table 2: The solid particle comprising an antioxidant (BHT)
  • Example 4 Comparison Example This example was done in analogy to example 2, but sucrose was used instead of trehalose.
  • Vitamin A acetate was for both tablets at 64%. It could be seen that the solid particles without antioxidant are as stable as the ones with an antioxidant.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
PCT/EP2018/062831 2017-05-19 2018-05-17 Solid particles Ceased WO2018210981A1 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
EP18723547.8A EP3624784A1 (en) 2017-05-19 2018-05-17 Solid particles
US16/613,915 US20200085777A1 (en) 2017-05-19 2018-05-17 Solid particles
BR112019023437-3A BR112019023437A2 (pt) 2017-05-19 2018-05-17 Partículas sólidas
KR1020197033613A KR20200007822A (ko) 2017-05-19 2018-05-17 고형 입자
JP2019554733A JP2020520894A (ja) 2017-05-19 2018-05-17 固体粒子
CN201880032301.9A CN110621308A (zh) 2017-05-19 2018-05-17 固体颗粒
JP2022169709A JP7506726B2 (ja) 2017-05-19 2022-10-24 固体粒子
US18/921,898 US20250041260A1 (en) 2017-05-19 2024-10-21 Solid particles

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17171890 2017-05-19
EP17171890.1 2017-05-19

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US16/613,915 A-371-Of-International US20200085777A1 (en) 2017-05-19 2018-05-17 Solid particles
US18/921,898 Continuation US20250041260A1 (en) 2017-05-19 2024-10-21 Solid particles

Publications (1)

Publication Number Publication Date
WO2018210981A1 true WO2018210981A1 (en) 2018-11-22

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PCT/EP2018/062831 Ceased WO2018210981A1 (en) 2017-05-19 2018-05-17 Solid particles

Country Status (7)

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US (2) US20200085777A1 (enExample)
EP (1) EP3624784A1 (enExample)
JP (2) JP2020520894A (enExample)
KR (1) KR20200007822A (enExample)
CN (1) CN110621308A (enExample)
BR (1) BR112019023437A2 (enExample)
WO (1) WO2018210981A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025012339A1 (en) * 2023-07-10 2025-01-16 Basf Se Solid preparations of vitamin a

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000008398A1 (it) 2020-04-20 2021-10-20 Mario Furieri Dispositivo per il lavaggio e l'asciugatura di manufatti in tessuto
IT202000024775A1 (it) * 2020-10-20 2022-04-20 Perfetti Van Melle Spa Prodotto di confetteria
EP4250959A1 (en) * 2020-11-30 2023-10-04 DSM IP Assets B.V. New formulations with reduced antioxidant content, their manufacture and use

Citations (5)

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Publication number Priority date Publication date Assignee Title
US2756177A (en) * 1953-03-09 1956-07-24 Hoffmann La Roche Process for making fat-soluble vitamin active powder
CA689790A (en) * 1964-06-30 A. Anderson Lawrence Solid, fat-soluble vitamin-active product and process for preparing the same
US20120058195A1 (en) * 2009-03-26 2012-03-08 Moti Harel Microencapsulation of bioactive substances and methods of making the same
WO2013053793A1 (en) * 2011-10-14 2013-04-18 Dsm Ip Assets B.V. Novel coating system
WO2017097974A1 (en) * 2015-12-10 2017-06-15 Dsm Ip Assets B.V. Vitamin formulation

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US20250041260A1 (en) 2025-02-06
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US20200085777A1 (en) 2020-03-19

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