WO2018193090A3 - Procédé de préparation d'hémitartrate d'eliglustat et d'intermédiaires de celui-ci - Google Patents
Procédé de préparation d'hémitartrate d'eliglustat et d'intermédiaires de celui-ci Download PDFInfo
- Publication number
- WO2018193090A3 WO2018193090A3 PCT/EP2018/060185 EP2018060185W WO2018193090A3 WO 2018193090 A3 WO2018193090 A3 WO 2018193090A3 EP 2018060185 W EP2018060185 W EP 2018060185W WO 2018193090 A3 WO2018193090 A3 WO 2018193090A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- intermediates
- preparation
- eliglustat hemitartrate
- eliglustat
- hemitartrate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
L'invention concerne un procédé de préparation d'hémitartrate d'eliglustat et d'intermédiaires de celui-ci. Elle concerne également des compositions pharmaceutiques stables à forme amorphe d'hémitartrate d'eliglustat comprenant la forme amorphe d'hémitartrate d'eliglustat, ainsi que leurs utilisations.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN201721014151 | 2017-04-21 | ||
IN201721014151 | 2018-03-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2018193090A2 WO2018193090A2 (fr) | 2018-10-25 |
WO2018193090A3 true WO2018193090A3 (fr) | 2019-01-03 |
Family
ID=62111029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2018/060185 WO2018193090A2 (fr) | 2017-04-21 | 2018-04-20 | Procédé de préparation d'hémitartrate d'eliglustat et d'intermédiaires de celui-ci |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2018193090A2 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112012012947B8 (pt) | 2009-11-27 | 2021-05-25 | Genzyme Corp | sal de hemitartarato e composição farmacêutica compreendendo o mesmo |
CN110759885B (zh) * | 2018-07-27 | 2021-10-22 | 中国医学科学院药物研究所 | 制备光活依格鲁特的方法 |
CN110878079A (zh) * | 2018-12-31 | 2020-03-13 | 北京启慧生物医药有限公司 | 一种高纯度依利格鲁司他的制备方法 |
EP3941917A4 (fr) * | 2019-03-22 | 2022-12-21 | Piramal Pharma Limited | Procédé amélioré pour la préparation d'éliglustat et de son intermédiaire |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004101558A1 (fr) * | 2003-05-13 | 2004-11-25 | F. Hoffmann-La Roche Ag | 2-imidazo-benzothiazoles constituant des ligands du recepteur de l'adenosine |
US7615753B2 (en) * | 2003-12-30 | 2009-11-10 | Commissariat A L'energie Atomique | Radiation detecting system with double resetting pulse count |
WO2011066352A1 (fr) * | 2009-11-27 | 2011-06-03 | Genzyme Corporation | Forme amorphe et cristalline de l'hémitartrate de genz 112638 au titre d'inhibiteur de la glucosylcéramide synthétase |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR122015016314B8 (pt) | 2001-07-16 | 2021-05-25 | Genzyme Corp | método para preparar um composto acíclico, método para preparar um composto amina, método para preparar um composto do tipo esfingosina e método para preparar um composto do tipo ceramida |
US6916802B2 (en) | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
US20170129869A1 (en) | 2014-07-03 | 2017-05-11 | Dr. Reddy's Laboratories Limited | Amorphous form of eliglustat hemitartarate |
CN105646442A (zh) | 2015-10-27 | 2016-06-08 | 北京凯莱天成医药科技有限公司 | 一种依利格鲁司他的制备方法 |
-
2018
- 2018-04-20 WO PCT/EP2018/060185 patent/WO2018193090A2/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004101558A1 (fr) * | 2003-05-13 | 2004-11-25 | F. Hoffmann-La Roche Ag | 2-imidazo-benzothiazoles constituant des ligands du recepteur de l'adenosine |
US7615753B2 (en) * | 2003-12-30 | 2009-11-10 | Commissariat A L'energie Atomique | Radiation detecting system with double resetting pulse count |
WO2011066352A1 (fr) * | 2009-11-27 | 2011-06-03 | Genzyme Corporation | Forme amorphe et cristalline de l'hémitartrate de genz 112638 au titre d'inhibiteur de la glucosylcéramide synthétase |
Non-Patent Citations (1)
Also Published As
Publication number | Publication date |
---|---|
WO2018193090A2 (fr) | 2018-10-25 |
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