WO2018187958A1

WO2018187958A1 - Sensing cup

Info

Publication number: WO2018187958A1
Application number: PCT/CN2017/080215
Authority: WO
Inventors: 何强
Original assignee: 广州阳普医疗科技股份有限公司
Priority date: 2017-04-12
Filing date: 2017-04-12
Publication date: 2018-10-18
Also published as: CN110998316B; CN110998316A

Abstract

A sensing cup, comprising: a sensing body (1) and a cup body (2). The cup body (2) is provided with an opening. The sensing body (1) comprises a cup lid (12). A cylindrical sensing area (14) is provided at a side of the cup lid (12). When the cup lid (12) and the opening are closed, the cylindrical sensing area (14) is provided within the cup body (2). A conical hole (11) is provided at the other side of the cup lid (12). The conical apex half angle of the conical hole (11) is less than a static friction conical angle. Because the design of the conical hole (11) of the sensing body (1) used for the insertion of a rotating rod complies with the principle of static friction cone, the sensing body (1) is prevented from falling off during testing and assembly processes, and a great working state can be maintained during the testing process, thus allowing the test result to be stable and accurate.

Description

Sensing cup

Technical field

The invention relates to the field of blood detection, and in particular to a sensing cup.

Background technique

At present, the thromboelastograph is an important tool for the detection of clinical coagulation. In actual clinical practice, it is found that the structural design defects of the sample sensing cup lead to instability and inaccuracy of the test results, which seriously affects the correctness of the doctor. And accurate diagnosis is extremely unfavorable for the diagnosis and treatment of patients.

Reference is made to the patent CN201420787158, which provides a sample cup assembly comprising a cup and a lid, the cup being a container having an opening at one end, the lid being capped with the opening of the cup The cup cover is provided with a stirring flap facing the surface of the cup body, the stirring flap is accommodated in the cup body, and the cup cover is provided with a through hole that cooperates with the rotating rod, so that the rotating rod Inserting the through hole drives the cup cover to rotate.

The defects of the above sample cup assembly are:

(1) Defects of the material, the sample cup assembly described above is a polypropylene material, the material is a hydrophobic material, the contact angle is large, the material itself is alienated from the blood, and the fibrin in the blood is difficult to adhere to the sensing body assembly. On the inner wall of the cup, a “sliding cup” phenomenon occurs during the test, that is, the blood clot is separated from the agitating fin and the inner surface of the cup during the whole blood coagulation test, resulting in inaccurate test results and test failure; (2) cup There is a design defect in the through hole of the cover and the rotating rod. Since the hole of the cup cover and the rotating rod is a through hole, during the actual coagulation detection process, the cup cover often leaves the rotating rod, which leads to the failure of the experiment; (3) the cup cover The structural design is flawed, and the cup cover is provided with a stirring flap on the surface of the cup body, which is easy to cut the blood clot during the blood coagulation detection process, and the stirring flap is thin and the material property is soft, and the fluctuation during the blood coagulation detection process is large. Very unstable, affecting the detection of coagulation, resulting in inaccurate test results or even test failure.

Summary of the invention

The invention provides a sensing cup which can maintain a good working state during the testing process, so that the test result is stable and accurate.

The technical solution of the sensing cup of the invention comprises:

Sensing body and cup;

The cup body is provided with an opening;

The sensing body includes a cup cover, and a side of the cup cover is provided with a cylindrical sensing area, and when the cup cover is closed with the opening, the cylindrical sensing area is placed in the cup body; The other side of the cup cover is provided with a tapered hole, and the cone top half angle of the tapered hole is smaller than the static friction cone angle.

Preferably,

The inner surface of the cup is composed of a closed surface perpendicular to the opening and a bottom surface connected to the closed surface; the cylindrical sensing region, the closed surface and the bottom surface are both sanded and coated with a reagent layer.

Preferably,

The bottom surface is a circular arc concave surface.

Preferably,

The cylindrical sensing region and the closing surface have a frosting depth of 0.01016 to 0.1143 mm, and the minimum releasing angle is 1 to 6.5.

Preferably,

The bottom surface has a matte depth of 0.0254 to 0.1524 mm and a minimum draft angle of 1.5 to 9 degrees.

Preferably,

The cylindrical sensing area is solid, and the bottom end surface is a circular arc convex surface, and the circular convex surface is located at a sphere whose diameter is smaller than the diameter of the spherical body of the circular concave surface.

Preferably,

The sensing body is further provided with a limiting step, the limiting step is located between the cup cover and the cylindrical sensing area, and when the sensing body is covered with the opening, the limiting step There is a gap between the closed face and the closed face.

Preferably,

The sensing cup material is a transparent acrylonitrile-butadiene-styrene copolymer.

Preferably,

The cup body is provided with a handle.

The beneficial effects of adopting the above technical solutions are:

The sensing cup of the present invention comprises a sensing body and a cup body, the cup body is provided with an opening, the sensing body comprises a cup cover, and a side of the cup cover is provided with a cylindrical sensing area, when the cup cover and the opening When the cover is closed, the cylindrical sensing area is placed on the cup body; the other side of the cup cover is provided with a tapered hole, and the tapered hole The half angle of the cone top is smaller than the static friction cone angle. Since the taper hole of the sensing body for inserting the sensing body of the rotating rod conforms to the principle of the static friction cone, the sensing body can be prevented from slipping during the test and assembly process, and the working state can be maintained during the test, so that the test result is stable. And accurate.

DRAWINGS

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the description of the prior art will be briefly described below. Obviously, the drawings in the following description are only It is an embodiment of the present invention, and those skilled in the art can obtain other drawings according to the provided drawings without any creative work.

1 is an exploded view of a sensing cup according to an embodiment of the present invention;

2(a) and 2(b) are a structural view and a cross-sectional view of a sensing body in a sensing cup according to an embodiment of the present invention;

3(a) and 3(b) are a plan view and a structural view of a cup body in a sensing cup according to an embodiment of the present invention;

4(a) and 4(b) are diagrams showing the force diagram and the parallelogram of the force of the sensing body in the sensing cup according to the embodiment of the present invention;

5(a) and 5(b) are schematic diagrams showing the force diagram of the sensing body in the stationary state of the sensing cup and the mechanical schematic diagram of the tapered cone friction cone;

Figure 6 is a graphical representation of the curve of the elastic deformation factor K and the relative support ratio parameter ξ;

Figure 7 is a graphical representation of the design principle of the tumbler of the sensing body;

FIG. 8 is a cross-sectional view of a sensing cup and a schematic diagram of static force according to an embodiment of the present invention.

detailed description

The technical solutions in the embodiments of the present invention are clearly and completely described in the following with reference to the accompanying drawings in the embodiments of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, but not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative efforts are within the scope of the present invention.

As shown in FIG. 1, the sensing cup of the present invention includes a sensing body 1 and a cup 2.

1 and 3 (a) (b), the cup 2 includes a handle 21 and a cup 22, the cup body 22 is a container having an opening at one end.

1 and 2(a)(b), the sensing body 1 includes a cup cover 12, and one side of the cup cover 12 is provided with a cylindrical sensing area 14, which is sensed when the cup cover 12 is closed with the opening. The measuring area 14 is built in the cup body 2; the other side of the cup cover 12 is provided with a tapered hole 11 , and the cone top half angle of the tapered hole 11 is smaller than the static friction cone angle, so that the rotating rod is inserted into the tapered hole 11 to drive the sensing body 1 to rotate. The blood clotting condition of the blood sample in the cup 22 can be sensed and detected by the cylindrical sensing region 14 on the sensing body 1. It should be noted that the rotating rod is disposed on the rotating unit, which belongs to the prior art and will not be described herein. Further, as shown in FIG. 2b, the cross-sectional area of the tapered hole 11 gradually decreases in a direction close to the cup cover 12, and the bottom surface of the tapered hole 11 can extend to the cylindrical sensing region 14.

Since the taper half angle of the tapered hole 11 of the sensing body 1 in the present invention is smaller than the static friction angle, that is, the design of the tapered hole 11 of the sensing body 1 for inserting the rotating body 1 conforms to the principle of the static friction cone, and can be avoided. The sensing body 1 slips during testing and assembly.

4(a)(b), the sensor body 1 is first simplified as a dot, and the friction factor is introduced. The friction factor is the ratio of the normal load to the tangential friction force, that is, μ=F _N /Fμ=tanρ (FN is the reaction force applied to the rotating rod), and the friction angle ρ=arctanμ is introduced. According to the parallelogram rule of force, it can be concluded that the resultant force of the tangential friction force Fμ and the normal load F _N is FR, and the angle ρ between FR and Fμ is called the friction angle.

In order to make the taper hole 11 have a certain clamping force on the rotating rod, the surface roughness of the taper hole 11 is 0.05 mm or more. According to the modern theory of solid friction, the frictional force has a molecular component and a mechanical deformation component, when the surface roughness value Ra When it is larger than 50 μm, the molecular component is negligible, so according to the modern friction theory, the mechanical deformation component is the main frictional force.

The friction factor μ is calculated as:

among them:

The tensile hysteresis loss factor α=0.08～0.12; r is the microscopic contour peak radius, which is 0.01016~0.1mm; h is the depth of the indented surface when the interaction force is obtained, and the value is h=0.01～0.0287mm; K is the factor of the relative support ratio curve parameter 弹性 during elastic deformation, and the relative support ratio curve parameter is between 1.8 and 3.

As shown in Fig. 5(a)(b), when the sensing body 1 is engaged with the rotating rod, whether it is stationary or in the test, or when loading and unloading the sensing body 1, the tangential force along the contact surface does not matter. How to change, the formula ρ=arctanμ is always true. The mechanical analysis of the sensing body 1 is carried out. When the sensing body 1 is unloaded but the rotor is not removed from the rotating shaft, the friction force is the largest, and the gravity G and the external force f are in the same direction, that is, the critical friction force.

at this time

A combined force with the pressure FNf of the rotating shaft of the rotating body of the sensing body 1 forms a static friction cone having a cone angle of 2θ. When the resultant force of Fμ and F _N is located in the static friction cone, the object will not slide, that is, the friction angle ρ is smaller than a certain critical angle (the critical angle is the static friction angle), and the object will not slide.

Through the above description, it can be understood that the taper hole 11 in the sensing body 1 conforms to the principle of the static friction cone, and no sliding phenomenon occurs, which solves the problem that the experiment body 1 is out of the turntable rotating rod during the blood coagulation detection process and the experiment fails.

As shown in FIG. 7, the structure of the sensing body 1 has a "tumbler" mechanical principle. The "upper end" of the sensing body 1 has an end surface having a tapered hole 11, and the "lower end" is a direction in which the sensing body 1 faces the inner surface of the cup bottom (hereinafter both ends of the sensing body 1 are described by "upper end" and "lower end"). The sensing body 1 has a tapered hole 11 at the upper end, a hollow body on the shape, and a light weight; the lower end is a cylindrical and solid hemisphere, and the weight is large, and the center of gravity of the sensing body 1 is within the hemisphere. It can be understood that the region of the cylindrical sensing region 14 excluding the tapered hole 11 is a solid structure.

The force applied by the sensing body 1 in the cup 2 is the force G and the supporting force FN of the cup 2 to it. When the sensing body 1 is placed tilted, the bottom surface 131 of the cylindrical sensing area is in contact with the bottom surface 222 of the cup body, the center of gravity of the sensing body 1 is O, the contact point is C, the gravity is G, the angle α is inclined, and a tilt state is maintained. The force F, the distance from point F to point C is m, AO, OC are i and d, respectively. When the sensing body 1 is inclined, it is bound to receive an external force F, and an interference torque M1 is generated. The interference torque is M1=F*m, and the gravity G forms a righting moment M2, and the righting moment is M2=Gcosβ*d. At this time, the two torque directions are opposite, and as the angle α of the inclination of the sensing body 1 increases, the offset of the gravity action line G also increases, and the value of the righting moment M2, that is, Gcosβ*d, also increases. When the righting moment M2 is equal to the disturbance moment M1, the sensing body 1 enters a new equilibrium state--balanced equilibrium state. When the external force F is withdrawn, it will automatically return to the equilibrium position of the original center under the action of the righting moment M2. The principle of the tumbler mechanics of the sensing body 1 is also established from the following points: (1) The potential energy angle. Objects with low potential energy are relatively stable, and objects must change toward a state with low potential energy. When the axial matching of the sensing body 1 and the cup body 22 is no longer a center line, since the sensing area 13 in which most of the center of gravity is concentrated is raised, the potential energy is increased, so the sensing body 1 is returned to the original center. s position. (2) The principle of leverage. When the sensing body 1 is tilted, the center of gravity is always at the point of action. The lower end portion, no matter where the fulcrum is, although the force arm of the sensing area is short, but the torque = force * force arm, the sensing body 1 will return to the original center position because the torque at the end of the cylindrical sensing area 14 is large. (3) The lower end surface of the sensing body 1 has a circular arc shape, and the friction force is small, and it is easy to slide into the center position under the action of gravity.

As described above, the tumbler mechanics principle design method of the sensing body 1 can avoid the fact that the sensing body 1 cannot be accurately placed in the center position of the cup body 22 in actual operation, resulting in inaccurate results, thereby ensuring the sensing body 1 Loading accuracy and accuracy of inspection.

The sensing cup in the present invention has the following contents in addition to the above-mentioned taper hole 11 having a cone top half angle smaller than the static friction angle:

The cup cover 12 of the sensing body 1 is closed with the opening of the cup body 22. The cup cover 12 can be a 1 mm thick cylindrical cover and is used for closing the opening. There is also a limit between the cup cover 12 and the cylindrical sensing area 14. The step 13, the limit step 13 is a cup cover 12 having a thickness of 0.8 mm and a diameter smaller than a cylinder, and is accommodated in the cup body 22. From the above description, it is clear that there is an assembly gap s between the outer edge of the limiting step 13 and the inner surface of the cup body 22, and s is 0.1 to 0.5 mm, thereby limiting the sensing body 1.

The sensing body 1 is provided with a cylindrical sensing region 14 for sensing coagulation toward the inner surface of the cup body 22, and the cylindrical sensing region 14 is housed in the cup body 22. The cylindrical sensing area 14 includes a cylindrical sensing area side 132 and a cylindrical sensing area bottom surface 131. The cylindrical sensing area bottom surface 131 can be designed as a circular convex surface matching the cup bottom surface 222, and the cup bottom surface 222 can be a circular arc concave surface. The diameter of the sphere at the bottom surface 131 of the cylindrical sensing area is much smaller than the diameter of the sphere where the bottom surface 222 of the cup is located. As shown in FIG. 2, the sensing region 14 of the sensing body 1 is designed as a cylindrical structure, which can uniformly sense the change of blood coagulation during the blood coagulation test, and minimize the instability of the blood coagulation process. The sensor body of the fin structure is unstable in detecting the blood coagulation process.

The inner surface of the cup body 22 is composed of a closing surface 221 perpendicular to the opening and a bottom surface 222 of the cup body connected to the closing surface 221, and the bottom surface 222 of the cup body is designed as a concave arc surface, which facilitates the gravity of the sensing body 1 when tilted. It is easier to slide into the center position under the action of the machine, so as to avoid the fact that the sensor body 1 is difficult to insert into the taper hole 11 or the insertion taper hole 11 due to the excessive deviation from the center in actual operation, and the error is not accurate. And instability issues.

The cylindrical sensing region 14 of the sensing body 1 and the inner surface of the cup body 22 are both frosted and coated with a reagent layer for increasing the surface area and improving the sensitivity. The cylindrical sensing region side 132 and the cylindrical sensing region bottom surface 131 and the closing surface 221 perpendicular to the opening have a matte depth at Between 0.01016 and 0.1143mm, the minimum draft angle is between 1° and 6.5°. The bottom surface of the cup body 222 with a concave arc shape is between 0.0254 and 0.1524 mm, and the minimum draft angle is between 1.5° and 9°. Between, used to increase the blood contact area, so that the fibrin in the blood can better adhere to the surface. The reagent layer cooperates with the coagulation mechanism to prevent the blood clot from coming off the surface of the cylinder sensing area 14 during the detection of blood coagulation, resulting in inaccurate test results and test failure, increasing the sensitivity of the sensing coagulation process and measurement, and improving the accuracy of the test. Sex.

The sensing cup assembly materials provided by the invention are all transparent acrylonitrile-butadiene-styrene copolymers, specifically MABS PA-758 (MABS chemical name is methyl methacrylate-acrylonitrile-butadiene-benzene) Vinyl plastic, PA-758 is a model) or acrylic based resin. The above materials are hydrophilic materials with a contact angle of between 65° and 85°, which enables fibrin in the blood to adhere better to the surface, increasing the sensitivity of the blood coagulation process and measurement. The problem of inaccurate and unsuccessful test results caused by the "sliding cup" phenomenon caused by blood clots falling off the surface of the sensing body and the inner surface of the cup during the blood coagulation detection process is solved.

The above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to be limiting; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that The technical solutions are described as being modified, or equivalent to some of the technical features, and the modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

A sensing cup, comprising: a sensing body and a cup;

The cup body is provided with an opening;

The sensing body includes a cup cover, and a side of the cup cover is provided with a cylindrical sensing area, and when the cup cover is closed with the opening, the cylindrical sensing area is placed in the cup body; The other side of the cup cover is provided with a tapered hole, and the cone top half angle of the tapered hole is smaller than the static friction cone angle.

The sensor cup of claim 1 wherein said inner surface of said cup is comprised of a closure surface perpendicular to said opening and a bottom surface coupled to said closure surface; said cylindrical sensing region, said closure Both the face and the bottom face are sanded and coated with a reagent layer.

The sensor cup according to claim 2, wherein the bottom surface is a circular arc concave surface.
The sensing cup according to claim 2, wherein the cylindrical sensing region and the closing surface have a frosting depth of 0.01016 to 0.1143 mm and a minimum releasing angle of 1 to 6.5.
The sensor cup according to claim 2, wherein the bottom surface has a matte depth of 0.0254 to 0.1524 mm and a minimum draft angle of 1.5 to 9 degrees.
The sensing cup according to claim 3, wherein the cylindrical sensing region is solid, and the bottom end surface is a circular arc convex surface, and the circular arc convex surface has a sphere diameter smaller than a diameter of the spherical body of the circular arc concave surface.
The sensing cup according to claim 2, wherein the sensing body is further provided with a limiting step, the limiting step is located between the cup cover and the cylindrical sensing area, when the feeling When the measuring body is covered with the opening, a gap is formed between the limiting step and the closing surface.
The sensor cup of claim 1 wherein said sensing cup material is a transparent acrylonitrile-butadiene-styrene copolymer.
The sensor cup according to claim 8, wherein the transparent acrylonitrile-butadiene-styrene copolymer model is MABS PA-758 or an acrylic based resin.
The sensor cup of claim 1 wherein the cup is provided with a handle.