WO2018183779A1 - Détection multiple d'anticorps spécifiques à un isotype - Google Patents

Détection multiple d'anticorps spécifiques à un isotype Download PDF

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Publication number
WO2018183779A1
WO2018183779A1 PCT/US2018/025299 US2018025299W WO2018183779A1 WO 2018183779 A1 WO2018183779 A1 WO 2018183779A1 US 2018025299 W US2018025299 W US 2018025299W WO 2018183779 A1 WO2018183779 A1 WO 2018183779A1
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Prior art keywords
seq
dna
sequence
antibody
nucleotide sequence
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PCT/US2018/025299
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English (en)
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WO2018183779A8 (fr
Inventor
Carolyn Bertozzi
Stephen J. Galli
Kaori MUKAL
Peter Robinson
Cheng-Ting Tsai
Mindy Tsai
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The Board Of Trustees Of The Leland Stanford Junior University
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Application filed by The Board Of Trustees Of The Leland Stanford Junior University filed Critical The Board Of Trustees Of The Leland Stanford Junior University
Priority to AU2018243461A priority Critical patent/AU2018243461A1/en
Priority to KR1020197031427A priority patent/KR20190141679A/ko
Priority to EP18777364.3A priority patent/EP3601604A4/fr
Priority to US16/497,668 priority patent/US11656233B2/en
Priority to JP2019553563A priority patent/JP2020515267A/ja
Priority to CA3058451A priority patent/CA3058451A1/fr
Priority to CN201880030887.5A priority patent/CN110869514A/zh
Publication of WO2018183779A1 publication Critical patent/WO2018183779A1/fr
Publication of WO2018183779A8 publication Critical patent/WO2018183779A8/fr
Priority to US18/188,927 priority patent/US20230333116A1/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G01N33/686—Anti-idiotype
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
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    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/10—Nucleotidyl transfering
    • C12Q2521/101—DNA polymerase
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C12Q2521/501—Ligase
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    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/205—Aptamer
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/143—Multiplexing, i.e. use of multiple primers or probes in a single reaction, usually for simultaneously analyse of multiple analysis
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/179—Nucleic acid detection characterized by the use of physical, structural and functional properties the label being a nucleic acid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2458/00—Labels used in chemical analysis of biological material
    • G01N2458/10—Oligonucleotides as tagging agents for labelling antibodies

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  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
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  • Hematology (AREA)
  • Urology & Nephrology (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des procédés et des réactifs destinés à la détection multiple d'anticorps. En particulier, l'invention concerne la détection multiple d'anticorps à l'aide de conjugués antigène-ADN et anticorps-agent de liaison-ADN transportant des codes à barres d'ADN permettant d'identifier et de quantifier des isotypes d'anticorps pertinents pour une maladie, tels que ceux impliqués dans les réponses allergiques, les maladies auto-immunes, les infections et l'inflammation.
PCT/US2018/025299 2017-03-30 2018-03-29 Détection multiple d'anticorps spécifiques à un isotype WO2018183779A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AU2018243461A AU2018243461A1 (en) 2017-03-30 2018-03-29 Multiplex isotype-specific antibody detection
KR1020197031427A KR20190141679A (ko) 2017-03-30 2018-03-29 다중 동형-특이적 항체 검출
EP18777364.3A EP3601604A4 (fr) 2017-03-30 2018-03-29 Détection multiple d'anticorps spécifiques à un isotype
US16/497,668 US11656233B2 (en) 2017-03-30 2018-03-29 Multiplex isotype-specific antibody detection
JP2019553563A JP2020515267A (ja) 2017-03-30 2018-03-29 多重アイソタイプ特異的抗体の検出
CA3058451A CA3058451A1 (fr) 2017-03-30 2018-03-29 Detection multiple d'anticorps specifiques a un isotype
CN201880030887.5A CN110869514A (zh) 2017-03-30 2018-03-29 多重同型特异性抗体检测
US18/188,927 US20230333116A1 (en) 2017-03-30 2023-03-23 Multiplex Isotype-Specific Antibody Detection

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762479278P 2017-03-30 2017-03-30
US62/479,278 2017-03-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US16/497,668 A-371-Of-International US11656233B2 (en) 2017-03-30 2018-03-29 Multiplex isotype-specific antibody detection
US18/188,927 Division US20230333116A1 (en) 2017-03-30 2023-03-23 Multiplex Isotype-Specific Antibody Detection

Publications (2)

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WO2018183779A1 true WO2018183779A1 (fr) 2018-10-04
WO2018183779A8 WO2018183779A8 (fr) 2020-01-02

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PCT/US2018/025299 WO2018183779A1 (fr) 2017-03-30 2018-03-29 Détection multiple d'anticorps spécifiques à un isotype

Country Status (8)

Country Link
US (2) US11656233B2 (fr)
EP (1) EP3601604A4 (fr)
JP (1) JP2020515267A (fr)
KR (1) KR20190141679A (fr)
CN (1) CN110869514A (fr)
AU (1) AU2018243461A1 (fr)
CA (1) CA3058451A1 (fr)
WO (1) WO2018183779A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020154620A3 (fr) * 2019-01-25 2020-09-03 Psomagen Inc. Conjugués anticorps-adn ainsi que détection et traitement du hpv
WO2020251646A1 (fr) * 2019-06-11 2020-12-17 Enable Biosciences Inc. Dosage par compétition multiplex pour profiler des épitopes de liaison d'agents d'affinité pour une utilisation en diagnostic clinique
WO2021041611A1 (fr) * 2019-08-27 2021-03-04 University Of Central Florida Research Foundation, Inc. Méthode et dispositif de détection de pathogènes ou d'anticorps à l'aide de substances de signalisation non modifiées avec ou sans réactifs de détection non marqués
EP4206674A1 (fr) * 2021-12-28 2023-07-05 Encodia, Inc. Dosages de sérotypage et de profilage d'anticorps à haut débit

Families Citing this family (5)

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Publication number Priority date Publication date Assignee Title
WO2022109496A2 (fr) * 2020-11-23 2022-05-27 Pleno, Inc. Dosages codés
KR102482695B1 (ko) * 2020-12-04 2023-01-02 주식회사 엠디헬스케어 만성 두드러기의 진단 방법
WO2022140655A1 (fr) * 2020-12-23 2022-06-30 The Trustees Of Columbia University In The City Of New York Immunoessais par nanopores multiplexes électroniques à molécule unique permettant la détection de biomarqueurs
WO2022221706A1 (fr) * 2021-04-15 2022-10-20 Seqtech Diagnostics Llc Procédés d'identification et de quantification d'anticorps
WO2023190098A1 (fr) * 2022-03-31 2023-10-05 日本ハム株式会社 Kit d'examen et procédé d'examen pour allergène d'arachide

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WO2020154620A3 (fr) * 2019-01-25 2020-09-03 Psomagen Inc. Conjugués anticorps-adn ainsi que détection et traitement du hpv
CN113412336A (zh) * 2019-01-25 2021-09-17 普梭梅根公司 抗体dna缀合物及hpv检测与治疗
JP2022518515A (ja) * 2019-01-25 2022-03-15 プソマーゲン， インコーポレイテッド 抗体－ｄｎａ複合体及びｈｐｖの検出並びに治療
EP3914297A4 (fr) * 2019-01-25 2023-03-29 Psomagen, Inc. Conjugués anticorps-adn ainsi que détection et traitement du hpv
WO2020251646A1 (fr) * 2019-06-11 2020-12-17 Enable Biosciences Inc. Dosage par compétition multiplex pour profiler des épitopes de liaison d'agents d'affinité pour une utilisation en diagnostic clinique
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EP4206674A1 (fr) * 2021-12-28 2023-07-05 Encodia, Inc. Dosages de sérotypage et de profilage d'anticorps à haut débit

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CN110869514A (zh) 2020-03-06
US20200309784A1 (en) 2020-10-01
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