WO2018097763A1 - Stent intra-stomacal pour réduire le poids ou maigrir - Google Patents

Stent intra-stomacal pour réduire le poids ou maigrir Download PDF

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Publication number
WO2018097763A1
WO2018097763A1 PCT/RU2017/000872 RU2017000872W WO2018097763A1 WO 2018097763 A1 WO2018097763 A1 WO 2018097763A1 RU 2017000872 W RU2017000872 W RU 2017000872W WO 2018097763 A1 WO2018097763 A1 WO 2018097763A1
Authority
WO
WIPO (PCT)
Prior art keywords
stomach
stent
patient
nitinol
titanium nickelide
Prior art date
Application number
PCT/RU2017/000872
Other languages
English (en)
Russian (ru)
Inventor
Андрей Борисович БОНДАРЕВ
Original Assignee
Андрей Борисович БОНДАРЕВ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Андрей Борисович БОНДАРЕВ filed Critical Андрей Борисович БОНДАРЕВ
Publication of WO2018097763A1 publication Critical patent/WO2018097763A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/844—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents folded prior to deployment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M29/00—Dilators with or without means for introducing media, e.g. remedies

Definitions

  • An intragastric stent for weight loss or weight loss belongs to the field of medicine, to intragastric devices for the treatment of obesity.
  • the device of the intragastric stent is illustrated in figure 1, where the intragastric stent is shown in section and in the form in which it is inserted into the patient’s stomach, and where 1 is a wire of titanium nickelide (nitinol) - an alloy with a memory of a predetermined shape worn on it ends protective tips made of polyethylene - 2, flexible pipe made of silicone - 3, clogging plugs at the ends of the pipe made of silicone - 4.
  • Figure 2 shows
  • the intragastric stent is in working condition in the form of a cylindrical spring with at least two full turns in exactly the form that it takes while in the patient’s stomach.
  • the intragastric stent described above having a predetermined shape and size corresponding to the size of the patient’s stomach, allows it to be placed in the stomach without the use of general anesthesia, since before the placement and in the process of placement in the stomach it has the appearance of a straight wire (probe). Due to the unique property of titanium nickelide (nitinol) material - to recall a predetermined shape when it reaches a certain temperature when placed in the stomach, the intragastric stent, when heated to the patient’s body temperature, takes a predetermined shape of a cylindrical spring of predetermined sizes and performs not only the above functions, but and, in addition, allows for diagnostic endoscopic examinations, which is very difficult if there is an intra-gastric ba in the stomach the womb.
  • this intragastric stent has insufficient mechanical strength (it can mechanically break down in one or several places), since in conditions of prolonged continuous alternating loads produced by the stomach for the mechanical processing of food, a single-wire structure often does not withstand the loads applied to it.
  • the protective flexible pipe around the wire may be broken by a broken wire. Violation of the tightness of the protective pipe on the wire in case of mechanical failure, the ends of the destroyed wire coming out of the flexible pipe lead to injury to the stomach tissue, which will pose a risk to the patient's life and necessitates an immediate cavity operation.
  • Protective polyethylene tips extending beyond the pipe at both ends increase the likelihood of surface injury to the inner surface of the stomach.
  • an intragastric stent having in the installed state a cylindrical spring with at least two full turns, made of a wire component in the form of a single bundle of two wires made of titanium nickelide (nitinol) with protective tips at its ends, enclosed in a flexible pipe made of silicone, the ends of which are hermetically sealed with protective caps made of polyethylene and having at each end two holes with a diameter in the range from 2 to 5 millimeters (RF Patent N ° 153617).
  • FIG. 3 The device of the intragastric stent (RF Patent No. 153617) is illustrated in FIG. 3, where the intragastric stent is shown in section and in the form in which it is inserted into the patient’s stomach, and where the wire component in the form of a single bundle of two or more wires in a free-drawn state is indicated by the number 5, titanium nickelide (nitinol) wire constituents of the tourniquet - 6, protective tips made of polyethylene - 2, flexible tube made of silicone - 3, protective cork plugs made of polyethylene inside the silicone tube - 7, holes in the silicone tube to remove the stent, intragastric, esophageal stent extractor - 8.
  • titanium nickelide (nitinol) wire constituents of the tourniquet - 6 protective tips made of polyethylene - 2
  • flexible tube made of silicone - 3
  • protective cork plugs made of polyethylene inside the silicone tube - 7, holes in the silicone tube to remove the stent, intragastric, esoph
  • the described prototype is devoid of the shortcomings of the intragastric stent - an analogue (RF Patent N ° 147288 U1), but both of these intraventricular stents have two common serious drawbacks - they do not quickly deploy in the stomach, on the one hand, and, on the other hand, when the patient is removed from the stomach create great resistance when they are pulled due to the tendency of the wire component in the form a single bundle of two wires made of titanium nickelide (nitinol) to maintain its shape as a coil spring with at least two full turns, since all the wires included in it are thermally processed to maintain the described desired shape at the patient’s stomach temperature.
  • This circumstance creates great difficulties in removing the intragastric stent from the stomach, which crushes the conductor tube into an accordion, creating a risk of damage to the walls of the esophagus.
  • the aim of the present invention is to solve the problem of completely eliminating the possibility of squeezing a conductor tube into an accordion when removing an intragastric stent from the patient’s stomach, avoiding the threat of damage to the walls of the esophagus, guaranteed rapid deployment of the intragastric stent in a spiral in the patient’s stomach when it is installed.
  • the present invention which solves the above problem, consists in adding a wire of titanium nickelide (nitinol) in a superelastic state with a predetermined shape in a straight line to a wire component in the form of a single bundle of two wires of titanium nickelide (nitinol).
  • the technical result provided by the above feature is the elimination of the possibility of crushing the conductor tube into the accordion when removing the intragastric stent from the stomach and avoiding the risk of damage to the walls of the esophagus due to the fact that the wire from titanium nickelide (nitinol) in an inelastic state with a given shape in a straight line significantly facilitates the extraction of the intragastric stent from the stomach and guarantees the avoidance of the threat of damage to the walls of the esophagus, since, in an effort to straighten from a folded position a straight line, it actually expands the wire component, as soon as the opportunity to do so to retract the stent from the stomach into the tube conductor.
  • the superelastic wire in the wire component of titanium nickelide (nitinol) helps the stent to turn faster and more evenly when the stent is placed in the stomach due to the properties of superelasticity, which tend to straighten the wire, but together with a wire with a predetermined shape in the form of a cylindrical spring with at least than with two full turns, accelerates the formation of the described spring, giving it the most regular shape.
  • the device of the proposed intragastric stent is illustrated in FIG. 4, where the intragastric stent is shown in section and in the form in which it is inserted into the stomach patient, and where the wire component of titanium nickelide (nitinol) in the form of a single bundle - 5, consisting of two wires of titanium nickelide (nitinol) wires - 11 and titanium nickelide (nitinol) wires in a superelastic state in a given straight line shape - 12 , protective tips made of polyethylene at the ends of the wire component of titanium nickelide (nitinol) in the form of a single bundle of two or more wires - 2, a flexible pipe made of silicone, in which the wire component of titanium nickelide (nitinol) is enclosed in the form of a single bundle of two of titanium nickelide (nitinol) and titanium nickelide (nitinol) wires in a superelastic state in a predetermined straight line form - 3, protective polyethylene plugs fixing the wire
  • the algorithm for working with an intra-gastric stent is as follows.
  • an esophagogastrophobic microscope with a polyvinyl chloride tube pre-fitted on it is inserted into the patient’s stomach cavity.
  • the conduit tube has a length equal to the length from the oral cavity to the stomach cavity, in the same position it is fixed, and the esophagogastroscopic oscilloscope is removed.
  • an intragastric stent is inserted into the cavity of the stomach in the form of a straight wire, which, heating up in the stomach to the patient’s body temperature, turns into a spiral and bursts the walls of the stomach, giving the patient the feeling of its full filling. This is followed by control gastroscopy and extraction of the conductor tube.
  • the intragastric stent stimulates the nerve endings of the upper stomach associated with the center of saturation of the brain, and the patient does not experience hunger.
  • the intragastric stent can remain in the patient’s stomach for up to 12 months.
  • Extraction of the intragastric stent is carried out by an esophageal stent extractor or endoscopic loop using a conductor tube.
  • the implantation and extraction of the intragastric stent is performed under local anesthesia, which is commonly used for endoscopic examinations and is carried out by irrigation of the oral part of the pharynx.
  • Examples of the use of the proposed intragastric stent for weight loss or weight loss The data obtained as a result of the application of the proposed intragastric stent in comparison with the data of the prototype method, and each option was tested five times.
  • the intragastric stents of the prototype method when they were removed through the tube, the conductor three times crushed the tube when they were removed, which led to a partial violation of the mucous surface of the stomach, and was removed twice difficult, but without harmful consequences for the esophagus.
  • Intragastric stents of the proposed method in all five cases were removed without difficulty.
  • the use of the proposed method completely eliminated the risk of damage to the mucous surface and tissues of the esophagus.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention se rapporte au domaine de la médecine et est utilisée pour traiter l'obésité. Ce stent intra-stomacal se présente, une fois installé, sous forme d'un ressort cylindrique comprenant au moins deux spires complètes, et consiste en un garrot d'un seul tenant d'un composant filaire en nickelure titane (nitinol), un alliage ayant une mémoire de forme prédéfinie, dans un tube flexible de silicone bouché hermétiquement des deux côtés et disposé dans la cavité stomacale, et enroulé en une spirale d'une forme et de dimensions prédéfinies dans la cavité stomacale, dilatant la paroi de l'estomac et créant ainsi pour le patient une sensation de remplissage complet. Ainsi, la quantité de nourriture absorbée par le patient diminue fortement, et le patient perd constamment du poids pendant toute la période où le stent intra-stomacal se trouve dans son estomac. L'invention est caractérisée en ce que, lors de la mise en place du stent intra-stomacal dans l'estomac et lors de son retrait, il n'est pas nécessaire de recourir à des narcoses générales, et en ce qu'aucune lésion ne se forme pendant la présence du stent intra-stomacal dans l'estomac.
PCT/RU2017/000872 2016-11-24 2017-11-23 Stent intra-stomacal pour réduire le poids ou maigrir WO2018097763A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2016146134 2016-11-24
RU2016146134 2016-11-24

Publications (1)

Publication Number Publication Date
WO2018097763A1 true WO2018097763A1 (fr) 2018-05-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/RU2017/000872 WO2018097763A1 (fr) 2016-11-24 2017-11-23 Stent intra-stomacal pour réduire le poids ou maigrir

Country Status (1)

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WO (1) WO2018097763A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1583534A1 (ru) * 1988-04-19 1990-08-07 Южный научно-исследовательский институт гидротехники и мелиорации Устройство дл очистки дрен
RU2429804C2 (ru) * 2005-12-02 2011-09-27 Пнн Медикал А/С Стент
RU153617U1 (ru) * 2015-01-12 2015-07-27 Андрей Борисович Бондарев Стент внутрижелудочный
RU2596873C1 (ru) * 2015-04-24 2016-09-10 Андрей Борисович Бондарев Способ снижения и коррекции массы тела с использованием физического воздействия на сознание человека созданием у него состояния чувства сытости или отсутствия аппетита

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU1583534A1 (ru) * 1988-04-19 1990-08-07 Южный научно-исследовательский институт гидротехники и мелиорации Устройство дл очистки дрен
RU2429804C2 (ru) * 2005-12-02 2011-09-27 Пнн Медикал А/С Стент
RU153617U1 (ru) * 2015-01-12 2015-07-27 Андрей Борисович Бондарев Стент внутрижелудочный
RU2596873C1 (ru) * 2015-04-24 2016-09-10 Андрей Борисович Бондарев Способ снижения и коррекции массы тела с использованием физического воздействия на сознание человека созданием у него состояния чувства сытости или отсутствия аппетита

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