WO2018091983A1 - Formulation composite à base de plantes pour des soins de la bouche - Google Patents

Formulation composite à base de plantes pour des soins de la bouche Download PDF

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Publication number
WO2018091983A1
WO2018091983A1 PCT/IB2017/055454 IB2017055454W WO2018091983A1 WO 2018091983 A1 WO2018091983 A1 WO 2018091983A1 IB 2017055454 W IB2017055454 W IB 2017055454W WO 2018091983 A1 WO2018091983 A1 WO 2018091983A1
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WO
WIPO (PCT)
Prior art keywords
weight
sodium
mentha
total composition
oral care
Prior art date
Application number
PCT/IB2017/055454
Other languages
English (en)
Inventor
Zakir Osman MOHAMMED
Original Assignee
Mak Labs Private Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mak Labs Private Limited filed Critical Mak Labs Private Limited
Publication of WO2018091983A1 publication Critical patent/WO2018091983A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]

Definitions

  • the present disclosure generally relates to the field of composition for external application for oral care. More particularly, the present disclosure relates to the use of therapeutically formulated herbal dentifrice.
  • Oral pharmaceutical compositions serve dual purpose of cosmetic use and therapeutic effect.
  • the compositions intended for oral hygiene are formulated to cater to oral health like plaque, tartar, gingivitis, bleeding gums, premature loss of tooth, chipping of tooth enamel etc.
  • Formulations comprising of chemicals and synthetic products have long been found to have adverse effect.
  • Traditional medicinal systems like Ayurveda and Unani have been promoting the use of herbal ingredients in formulations.
  • These ingredients are preferably plant extracts which are obtained from various parts of the medicinal plants. For example: the clove oil obtained from clove is the bud of the plant, mint is a leaf, neem twigs have been used as a natural tooth brush etc.
  • Exemplary embodiments of the present disclosure are directed towards a composite herbal formulation for oral care.
  • An exemplary object of the present subject matter is directed towards a composite herbal formulation for oral care preferably in a paste form for easy application.
  • Another exemplary object of the present subject matter is directed towards the use of herbal components to have little or no side effects.
  • Another exemplary object of the present subject matter is directed towards the use of abrasives to remove food particles from in between the teeth.
  • Yet another exemplary object of the present subject matter is directed towards the prevention of bacterial growth and gum weakening.
  • Exemplary aspects of the present disclosure are directed towards a herbal active ingredient inclusive of at least one of: Ocimum filamentosum , Ocimum minimum, Ocimum kilimandscharicum,Eugenia aromatica (L.), Mentha spicata L.Mentha piperita, Mentha vagans, Mentha suaveolens, whereby the amount of active ingredient incorporated ranges between 0.25% to 2% weight by weight of the total composition.
  • An exemplary aspect of the present subject matter is directed towards an herbal active ingredient having Salvadora persica; Oscimum Bascillicum; Syzygium aromaticum; Ziziphus mauritiana; Mentha Longifolia; Olea europaea and Azardichta Indica with the amount of active ingredient being incorporated in ranges between 1.0 % to 1.5% weight by weight of the total composition.
  • Another exemplary aspect of the disclosure is directed towards an anti-carries agent incorporated as 1 % weight by weight of the total composition.
  • Another exemplary aspect of the disclosure is directed towards a thickening agent incorporated in the ranges between 1 % to 2.5% weight by weight of the total composition;
  • Another exemplary aspect of the disclosure are directed towards a surfactant incorporated ranges between 0.01% to 10% weight by weight of the total composition.
  • Yet another exemplary aspect of the disclosure is directed towards an aqueous phase comprising at least one of; glycerin and water incorporated ranges between 7.5% to 24% weight by weight of the total composition.
  • FIG 1 is a flow diagram illustrating the method employed for the preparation of a composite herbal formulation for oral care, according to an exemplary embodiment of the present disclosure.
  • FIG. 2 is a flow diagram illustrating a method employed for the preparation of a composite herbal formulation by the addition of Salvadora persica for oral care, according to an exemplary embodiment of the present disclosure.
  • the present disclosure provides a composite herbal formulation for oral care comprising of herbal active components
  • Nana Al- Fulfuli as in Tibbi and/or Mentha Longifolia as the botanical name, and/or Mint as the conventional name.
  • the present disclosure provides a composite herbal formulation for oral care comprising of excipients which are configured to have requisite therapeutic effect when a part of the formulation;
  • Raihaan as in Tibbi, and/or Oscimum Bascillicum as the botanical name, and/or Basil as the conventional name is used, not limiting to, the herbal formulation for oral care.
  • Basil is a phenolic derivative.
  • Basil is incorporated in the formulation for oral care as the chemical components in Basil aid the user in keeping oneself away from many mouth diseases such as gums diseases, pyorrhoea, and other dental infections.
  • Ziziphus species contain several phytochemicals not limited to saponins, pectin, fatty acids, triterpenoic acids, cyclopeptide alkaloids and the like without limiting the scope of the disclosure.
  • the property of Indian plum may not be limited to: an analgesic, an antiinflammatory, an antibacterial and the like, thus making it an essential ingredient for composite herbal oral care formulation.
  • Mint possesses germicidal qualities and rapidly freshens the breath.
  • the mechanism of action of mint involves the suppression of harmful bacterial growth within the oral cavity by cleansing the tongue and/or teeth.
  • neem Yavan Priya as in Tibbi, and/or Azardichta Indica as the botanical name, and/or Neem as the conventional name.
  • the use of neem for not limiting to strong teeth has been a part of oral health practices since time immemorial.
  • the neem leaves, neem bark and neem twig and the like have been used as a part of composite herbal formulation for oral care.
  • the incorporation of neem may be attributed to prevention and healing of gum diseases, prevention of cavities, elimination of bacteria causing cavities and inflammation of the gums, preventing bacteria from adhering to the user's teeth (reduce plaque), enhance mouth immunity in general, breath freshener and the like without limiting the scope of the disclosure.
  • the present disclosure provides a composite herbal formulation for oral care comprising of excipients which are configured to have requisite therapeutic effect when a part of the formulation.
  • the excipients comprise of; thickening agents not limited to Aerosil and Sodium CMC (Carboxy methyl cellulose) and carbapol 934.
  • An abrasive not limited to Calcium carbonate configured to impart shine and cleanliness to the enamel of the teeth by polishing and grinding effect.
  • Glycerin, a humectant is configured to impart a pasty texture to the toothpaste and keeps it from drying out and also, coats the teeth to prevent remineralisation.
  • Sodium monofluorophosphate acts with the insoluble compound produced after the consumption of high sugary meal to resist the attack degradation of apatite by loss of OH " (hydroxide ion) which would enable the dissolution of the enamel.
  • Sweeteners not limiting to Sodium Saccharin and Sorbitol may be incorporated for enhancing the palatability and masking the strong taste generated due to incorporation of various components in the composite herbal formulation for oral care.
  • Sodium lauryl sulphate acts as a surfactant which is involved in the creation of the foaming action.
  • Sodium lauryl sulphate is an anionic surfactant which combines with the debris in the oral cavity, chelates them and ensures that they are pulled out.
  • Chlorophyll a natural ingredient may be found in green leafy vegetables, green vegetables, algae and the like. Chlorophyll imparts colour. A colorant incorporated may not be limited to green. Glycerine along with water may be utilised as an aqueous base for incorporation and dissolution of both the active components and excipients.
  • composition for the composite herbal formulation for oral care is represented in the following table:
  • FIG. 1 is a flow diagram 100, illustrating the method employed for the preparation of a composite herbal formulation for oral care, according to an exemplary embodiment of the present disclosure.
  • the method involves both dry phase and aqueous phase which are subjected to step by step procedures to obtain the requisite composite herbal formulation for oral care.
  • the method starts at step 102, where the sifting of Calcium Carbonate, Xanthan Gum, Sodium Carboxy Methyl Cellulose and Carbapol 934 is done by passing them through sieve #40.
  • the sifted Calcium Carbonate, Xanthan Gum, Sodium Carboxy Methyl Cellulose and Carbapol 934 are placed in a planetary mixer with a vaccum provision and a capacity not limiting to 5000ml and subjected to mixing resulting in the formation of a dry mixture at step 104.
  • the process at step 104 was carried out at not limiting to 60% of relative humidity (RH) and at a temperature of not limiting to 20°C -25 °C.
  • RH relative humidity
  • the principle of geometrical dilution may be applied during the addition and mixing of the components.
  • predetermined quantities sorbitol and water are added preferably in a stainless steel container not limiting to 2000 ml capacity to form an aqueous mixture.
  • aqueous mixture Placing the aqueous mixture in water bath to increase the temperature to 50°C - 60 °C is done at step 108.
  • Pre-determined quantity of colorant (chlorophyll) is dissolved in a pre-determined quantity of glycerin and the mixture of chlorophyll dissolved in glycerin is added to the aqueous mixture at step 110.
  • Pre-determined quantities of aerosil sifted through a mesh # 80, Sodium Saccharin and Sodium mono fluoro phosphate were added to the aqueous solution with continuous stirring using propeller type agitator not limiting to 30 minutes to form a homogenous aqueous dispersion at step 112 which facilitates the formation of a homogenous dispersion.
  • Pre-determined quantities of Sodium Lauryl Sulphate were added to homogenous dispersion at step 114. Adding the homogenous aqueous dispersion to the dry sifted components into a planetary mixer for not limiting to 15 minutes to form a wet mass at step 116.
  • the forms of basil oil (Oscimum BasciUicum), clove oil (Syzygium aromaticum), Unnab (Ziziphus mauritiana), Zaitoon (Olea europaea), and extract of Neem (Azardicta Indica) were de aerated at step 118.
  • the deaerated basil oil (Oscimum BasciUicum), clove oil (Syzygium aromaticum), Unnab (Ziziphus mauritiana), Zaitoon (Olea europaea), and extract of Neem (Azardicta Indica) were added to the wet mass obtained at step 116 by continuous agitation for not limiting to 60 minutes to form a homogenous mass at step 120. Adequate controls may be kept in assessing the homogeneity of mass for the oil levels. Further, at step 122, a pre-determined quantity of Mentha Longifolia (Nana-al - Fulfuli) was added to the homogenous mass obtained at step 120. Finally, mixing the contents of step 122 for 30 minutes at lOOrpm under vacuum to obtain the requisite composite herbal formulation for oral care at step 124.
  • the present disclosure provides a composite herbal formulation for oral care comprising of herbal active components:
  • Olea europaea as the botanical name, and/or Olive as the conventional name available at a percentage, not limiting to, 1.5 % of the composition.
  • the present disclosure provides a composite herbal formulation for oral care comprising of excipients which are configured to have requisite therapeutic effect when a part of the formulation;
  • Meswak known with the botanical name Salvadora persica was used admirwhile as a teeth whitener and polishing agent.
  • Meswak is known to have antimicrobial properties especially against oral bacteria and exhibits minimal and/or no mammalian toxicity.
  • the cleansing efficacy of Meswak is normally by leaching out in saliva, and for their antifungal properties which is attributed to active chemical constituents, not limited to, sodium chloride, potassium chloride, salvadourea, alkaloids, oleic acid and linoleic acids.
  • composition for the composite herbal formulation for oral care is represented in the following table:
  • Chlorophyll 0.5 10.0
  • FIG. 2 is a flow diagram 200, illustrating a method employed for the preparation of a composite herbal formulation by the addition of Salvadora persica for oral care, according to an exemplary embodiment of the present disclosure.
  • the method involves both dry phase and aqueous phase which are subjected to step by step procedures to obtain the requisite composite herbal formulation for oral care.
  • the method starts at step 202, where the presifted Calcium Carbonate, Xanthan Gum, and sodium silicate are passed them through sieve #40.
  • the presifted Calcium Carbonate, Xanthan Gum, and sodium silicate are placed in a high shear mixer with a vacuum provision and a capacity not limiting to 5000ml step 204.
  • the process at step 204 was carried out at not limiting to 60% of relative humidity (RH) and at a temperature of not limiting to 20°C -25 °C.
  • RH relative humidity
  • the principle of geometrical dilution may be applied during the addition and mixing of the components.
  • predetermined quantities sorbitol was added to water preferably in a stainless steel container not limiting to 2000 ml capacity to form an aqueous mixture. Placing the aqueous mixture in a water batch to increase the temperature to 50°C -60 °C is done at step 208.
  • Pre-determined quantity of colorant (chlorophyll) is dissolved in a pre-determined quantity of glycerin and the mixture of chlorophyll dissolved in glycerin is added to the aqueous mixture at step 210.
  • Pre-determined quantities of aerosil sifted through a mesh # 80, Sodium Saccharin and Sodium mono fluoro phosphate and Coca amido propyl betaine were added to the aqueous solution with continuous stirring using propeller type agitator not limiting to 30 minutes to form a homogenous aqueous dispersion at step 212.
  • Pre-determined quantities of Sodium Lauryl Sulphate were added to aqueous homogenous dispersion at step 214.
  • the wet mass obtained is subjected to an agitation speed of lOOrpm for 60 min under vacuum to prevent the formation of foam.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Inorganic Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

Des modes de réalisation, donnés à titre d'exemple, de la présente invention concernent une formulation composite à base de plantes pour des soins de la bouche, comprenant les plantes suivantes : Ocimum filamentosum, Ocimum minimum, Ocimum kilimandscharicum, Eugenia aromatica (L.), Mentha spicata L., Mentha piperita, Mentha vagans, Mentha suaveolens, Salvadora persica, Oscimum Bascillicum, Syzygium aromaticum, Ziziphus mauritiana, Mentha longifolia, Olea europaea et Azadirachta indica, la quantité des principes actifs incorporés étant comprise entre 0,25 % et 2 % en poids de la composition totale ; un agent anticariogène incorporé à 1 % en poids et correspondant à entre 1,0 % et 1,5 % de la composition totale ; un agent épaississant incorporé à des valeurs comprises entre 1 % et 2,5 % en poids de la composition totale ; un tensioactif incorporé à des valeurs comprises entre 0,01 % et 10 % en poids de la composition totale ; et une phase aqueuse comprenant au moins l'un des composés suivants, la glycérine et l'eau, incorporés à des valeurs comprises entre 7,5 % et 24 % en poids de la composition totale.
PCT/IB2017/055454 2016-11-16 2017-09-11 Formulation composite à base de plantes pour des soins de la bouche WO2018091983A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN201641039065 2016-11-16
IN201641039065 2016-11-16
IN201743012909 2017-04-11
IN201743012909 2017-04-11

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WO2018091983A1 true WO2018091983A1 (fr) 2018-05-24

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021052551A3 (fr) * 2019-09-17 2021-05-27 محمود جلال، Base de gomme à mâcher et composition naturelles et sûres per os
DE202022104177U1 (de) 2022-07-23 2022-08-03 Sunita Arya Neuartige Zusammensetzung eines Biopestizids zur Vorab-Begasung

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011068815A1 (fr) * 2009-12-04 2011-06-09 Colgate-Palmolive Company Compositions orales contenant des extraits de zizyphus joazeiro et procédés associés
WO2011068812A1 (fr) * 2009-12-04 2011-06-09 Colgate-Palmolive Company Compositions orales contenant une combinaison d'extraits naturels et procédés connexes

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011068815A1 (fr) * 2009-12-04 2011-06-09 Colgate-Palmolive Company Compositions orales contenant des extraits de zizyphus joazeiro et procédés associés
WO2011068812A1 (fr) * 2009-12-04 2011-06-09 Colgate-Palmolive Company Compositions orales contenant une combinaison d'extraits naturels et procédés connexes

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
DATABASE TKDL "Dantak|rcik (03) Knowledge known since 500 years", Database accession no. RS/3007C *
DATABASE TKDL [O] "" Mazmazah Infaq" ; Knowledge known since 1000 years", Database accession no. AA3/1041 *
DATABASE TKDL [O] "Dantapawan Yogah Knowledge known since 50 years", Database accession no. KS3/94A *
DATABASE TKDL [O] "Dawa Baraai Foul Smell Knowledge known since 200 years", Database accession no. JA7/488F *
DATABASE TKDL [O] "Dawa-e-firanjmushk Deegar Knowledge known since 1000 years.", Database accession no. MH6/256F *
DATABASE TKDL [O] "Miswaak-e- Bashaam Barae Muqawwi-e- Lissa Wa Danda Knowledge known since 100 years.", Database accession no. NA2/366I *
DATABASE TKDL [O] "Sanoon-e- Fudanaj Knowledge known since 1000 years", Database accession no. AA3/798 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021052551A3 (fr) * 2019-09-17 2021-05-27 محمود جلال، Base de gomme à mâcher et composition naturelles et sûres per os
DE202022104177U1 (de) 2022-07-23 2022-08-03 Sunita Arya Neuartige Zusammensetzung eines Biopestizids zur Vorab-Begasung

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